Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	RFPL4B PIAS4 RNF113B RNF31 ZSWIM2 TRIM47 PIAS1 TRIM38	1.86e-05	398	58	8	GO:0061659
GeneOntologyMolecularFunction	transition metal ion binding	PIAS4 ZNF22 RNF31 OGFOD2 EHMT1 NSD1 ZSWIM2 ZFR ZNFX1 CYP4F12 TRIM47 PIAS1 TRIM38	2.83e-05	1189	58	13	GO:0046914
GeneOntologyMolecularFunction	zinc ion binding	PIAS4 ZNF22 RNF31 EHMT1 NSD1 ZSWIM2 ZFR ZNFX1 TRIM47 PIAS1 TRIM38	4.36e-05	891	58	11	GO:0008270
GeneOntologyMolecularFunction	vitamin E binding	AFM NPC1L1	4.96e-05	4	58	2	GO:0008431
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	RFPL4B PIAS4 RNF113B RNF31 ZSWIM2 TRIM47 PIAS1 TRIM38	1.10e-04	512	58	8	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	RFPL4B PIAS4 RNF113B RNF31 ZSWIM2 TRIM47 PIAS1 TRIM38	1.43e-04	532	58	8	GO:0016755
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	RFPL4B RNF113B RNF31 ZSWIM2 TRIM47 TRIM38	7.18e-04	372	58	6	GO:0061630
GeneOntologyMolecularFunction	low-density lipoprotein particle binding	SCARF1 LDLR	1.23e-03	18	58	2	GO:0030169
GeneOntologyMolecularFunction	SUMO ligase activity	PIAS4 PIAS1	1.52e-03	20	58	2	GO:0061665
GeneOntologyMolecularFunction	acyltransferase activity	RFPL4B PIAS4 RNF113B RNF31 ZSWIM2 TRIM47 PIAS1 TRIM38	1.71e-03	775	58	8	GO:0016746
GeneOntologyMolecularFunction	extracellular matrix structural constituent	NID2 LAMA5 PAPLN SSPOP	2.17e-03	188	58	4	GO:0005201
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	RFPL4B RNF113B RNF31 ZSWIM2 TRIM47 TRIM38	2.44e-03	473	58	6	GO:0004842
MousePheno	abnormal artery morphology	PCSK5 ADORA2A ELP1 LAMA5 KLF3 FAS LDLR LEPR NOTCH3	1.57e-05	440	48	9	MP:0002191
Domain	EGF_2	SCARF1 NID2 LAMB4 LRP4 LAMA5 EGFL8 ADAM12 SSPOP LDLR NOTCH3	9.51e-09	265	59	10	PS01186
Domain	Growth_fac_rcpt_	SCARF1 PCSK5 NID2 ERBB3 LRP4 LAMA5 LDLR NOTCH3	3.06e-08	156	59	8	IPR009030
Domain	EGF-like_dom	SCARF1 PCSK5 NID2 LRP4 LAMA5 EGFL8 ADAM12 LDLR NOTCH3	8.10e-08	249	59	9	IPR000742
Domain	EGF_1	SCARF1 LAMB4 LRP4 LAMA5 EGFL8 ADAM12 SSPOP LDLR NOTCH3	9.92e-08	255	59	9	PS00022
Domain	EGF-like_CS	SCARF1 NID2 LAMB4 LRP4 LAMA5 EGFL8 ADAM12 LDLR NOTCH3	1.21e-07	261	59	9	IPR013032
Domain	EGF_3	SCARF1 NID2 LRP4 EGFL8 ADAM12 SSPOP LDLR NOTCH3	7.11e-07	235	59	8	PS50026
Domain	EGF	SCARF1 PCSK5 NID2 LRP4 LAMA5 EGFL8 LDLR NOTCH3	7.11e-07	235	59	8	SM00181
Domain	-	NID2 LRP4 ELP1 LDLR	6.80e-06	39	59	4	2.120.10.30
Domain	EGF_CA	NID2 LRP4 EGFL8 LDLR NOTCH3	7.58e-06	86	59	5	PF07645
Domain	Ldl_recept_b	NID2 LRP4 LDLR	1.06e-05	14	59	3	PF00058
Domain	LDLRB	NID2 LRP4 LDLR	1.06e-05	14	59	3	PS51120
Domain	LY	NID2 LRP4 LDLR	1.33e-05	15	59	3	SM00135
Domain	LDLR_classB_rpt	NID2 LRP4 LDLR	1.33e-05	15	59	3	IPR000033
Domain	6-blade_b-propeller_TolB-like	NID2 LRP4 ELP1 LDLR	1.33e-05	46	59	4	IPR011042
Domain	EGF_Ca-bd_CS	NID2 LRP4 EGFL8 LDLR NOTCH3	1.37e-05	97	59	5	IPR018097
Domain	EGF_CA	NID2 LRP4 EGFL8 LDLR NOTCH3	1.51e-05	99	59	5	PS01187
Domain	ASX_HYDROXYL	NID2 LRP4 EGFL8 LDLR NOTCH3	1.58e-05	100	59	5	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	NID2 LRP4 EGFL8 LDLR NOTCH3	2.10e-05	106	59	5	IPR000152
Domain	EGF_CA	NID2 LRP4 EGFL8 LDLR NOTCH3	4.14e-05	122	59	5	SM00179
Domain	EGF-like_Ca-bd_dom	NID2 LRP4 EGFL8 LDLR NOTCH3	4.47e-05	124	59	5	IPR001881
Domain	RING	RFPL4B RNF113B RNF31 NSD1 ZSWIM2 TRIM47 TRIM38	4.77e-05	305	59	7	SM00184
Domain	PINIT	PIAS4 PIAS1	5.86e-05	4	59	2	IPR023321
Domain	PINIT	PIAS4 PIAS1	5.86e-05	4	59	2	PS51466
Domain	PINIT	PIAS4 PIAS1	5.86e-05	4	59	2	PF14324
Domain	Znf_RING	RFPL4B RNF113B RNF31 NSD1 ZSWIM2 TRIM47 TRIM38	7.25e-05	326	59	7	IPR001841
Domain	GF_recep_IV	PCSK5 ERBB3	1.46e-04	6	59	2	PF14843
Domain	GF_recep_IV	PCSK5 ERBB3	1.46e-04	6	59	2	IPR032778
Domain	TNFR/NGFR_Cys_rich_reg	TNFRSF12A LAMA5 FAS	1.53e-04	33	59	3	IPR001368
Domain	Znf_RING_CS	RFPL4B RNF113B RNF31 TRIM47 TRIM38	1.63e-04	163	59	5	IPR017907
Domain	Laminin_EGF	SCARF1 LAMB4 LAMA5	1.82e-04	35	59	3	PF00053
Domain	zf-MIZ	PIAS4 PIAS1	2.04e-04	7	59	2	PF02891
Domain	ZF_SP_RING	PIAS4 PIAS1	2.04e-04	7	59	2	PS51044
Domain	Laminin_EGF	SCARF1 LAMB4 LAMA5	2.33e-04	38	59	3	IPR002049
Domain	Znf_MIZ	PIAS4 PIAS1	2.71e-04	8	59	2	IPR004181
Domain	LDLR_class-A_CS	LRP4 SSPOP LDLR	2.72e-04	40	59	3	IPR023415
Domain	ZF_RING_1	RFPL4B RNF113B RNF31 ZSWIM2 TRIM47 TRIM38	3.06e-04	291	59	6	PS00518
Domain	ZF_RING_2	RFPL4B RNF113B RNF31 ZSWIM2 TRIM47 TRIM38	3.48e-04	298	59	6	PS50089
Domain	Ptc/Disp	NPC1L1 DISP1	3.48e-04	9	59	2	IPR003392
Domain	Patched	NPC1L1 DISP1	3.48e-04	9	59	2	PF02460
Domain	Ldl_recept_a	LRP4 SSPOP LDLR	3.87e-04	45	59	3	PF00057
Domain	-	LRP4 SSPOP LDLR	4.13e-04	46	59	3	4.10.400.10
Domain	PRY	RFPL4B TRIM47 TRIM38	4.68e-04	48	59	3	SM00589
Domain	LDLRA_1	LRP4 SSPOP LDLR	4.68e-04	48	59	3	PS01209
Domain	PRY	RFPL4B TRIM47 TRIM38	4.68e-04	48	59	3	IPR006574
Domain	LDLRA_2	LRP4 SSPOP LDLR	4.98e-04	49	59	3	PS50068
Domain	LDrepeatLR_classA_rpt	LRP4 SSPOP LDLR	4.98e-04	49	59	3	IPR002172
Domain	LDLa	LRP4 SSPOP LDLR	4.98e-04	49	59	3	SM00192
Domain	-	RFPL4B PIAS4 RNF113B NSD1 ZSWIM2 TRIM47 TRIM38	5.14e-04	449	59	7	3.30.40.10
Domain	Znf_RING/FYVE/PHD	RFPL4B PIAS4 RNF113B NSD1 ZSWIM2 TRIM47 TRIM38	5.85e-04	459	59	7	IPR013083
Domain	EGF	NID2 LRP4 EGFL8 NOTCH3	6.75e-04	126	59	4	PF00008
Domain	SSD	NPC1L1 DISP1	7.48e-04	13	59	2	IPR000731
Domain	SSD	NPC1L1 DISP1	7.48e-04	13	59	2	PS50156
Domain	PLAC	PCSK5 PAPLN	8.71e-04	14	59	2	PF08686
Domain	EGF_extracell	SCARF1 ADAM12 NOTCH3	9.02e-04	60	59	3	IPR013111
Domain	EGF_2	SCARF1 ADAM12 NOTCH3	9.02e-04	60	59	3	PF07974
Domain	Laminin_N	LAMB4 LAMA5	1.14e-03	16	59	2	IPR008211
Domain	LAMININ_NTER	LAMB4 LAMA5	1.14e-03	16	59	2	PS51117
Domain	Laminin_N	LAMB4 LAMA5	1.14e-03	16	59	2	PF00055
Domain	LamNT	LAMB4 LAMA5	1.14e-03	16	59	2	SM00136
Domain	EMI	EGFL8 SSPOP	1.29e-03	17	59	2	PS51041
Domain	Butyrophylin	RFPL4B TRIM47 TRIM38	1.41e-03	70	59	3	IPR003879
Domain	Furin_repeat	PCSK5 ERBB3	1.45e-03	18	59	2	IPR006212
Domain	FU	PCSK5 ERBB3	1.45e-03	18	59	2	SM00261
Domain	PLAC	PCSK5 PAPLN	1.62e-03	19	59	2	PS50900
Domain	PLAC	PCSK5 PAPLN	1.62e-03	19	59	2	IPR010909
Domain	-	PIAS4 PIAS1	1.98e-03	21	59	2	1.10.720.30
Domain	SAP	PIAS4 PIAS1	2.18e-03	22	59	2	PF02037
Domain	SAP	PIAS4 PIAS1	2.38e-03	23	59	2	SM00513
Domain	SAP	PIAS4 PIAS1	2.81e-03	25	59	2	PS50800
Domain	SAP_dom	PIAS4 PIAS1	2.81e-03	25	59	2	IPR003034
Domain	cEGF	NID2 LRP4	3.04e-03	26	59	2	IPR026823
Domain	cEGF	NID2 LRP4	3.04e-03	26	59	2	PF12662
Domain	SPRY	RFPL4B TRIM47 TRIM38	3.27e-03	94	59	3	PF00622
Domain	SPRY_dom	RFPL4B TRIM47 TRIM38	3.27e-03	94	59	3	IPR003877
Domain	Galactose-bd-like	PCSK5 LAMA5 SSPOP	3.27e-03	94	59	3	IPR008979
Domain	B30.2/SPRY	RFPL4B TRIM47 TRIM38	3.37e-03	95	59	3	IPR001870
Domain	B302_SPRY	RFPL4B TRIM47 TRIM38	3.37e-03	95	59	3	PS50188
Pubmed	Znf202 affects high density lipoprotein cholesterol levels and promotes hepatosteatosis in hyperlipidemic mice.	ZNF202 LDLR	3.03e-06	2	61	2	23469003
Pubmed	Hematopoietic Fas deficiency does not affect experimental atherosclerotic lesion formation despite inducing a proatherogenic state.	FAS LDLR	3.03e-06	2	61	2	21550016
Pubmed	Enhancement of bio-protective functions by low dose/dose-rate radiation.	FAS LEPR	3.03e-06	2	61	2	18648588
Pubmed	The role of macrophage leptin receptor in aortic root lesion formation.	LDLR LEPR	3.03e-06	2	61	2	18182468
Pubmed	Hepatic Expression of Niemann-Pick C1-Like 1, a Cholesterol Reabsorber from Bile, Exacerbates Western Diet-Induced Atherosclerosis in LDL Receptor Mutant Mice.	NPC1L1 LDLR	3.03e-06	2	61	2	31064810
Pubmed	Alkylresorcinols as New Modulators of the Metabolic Activity of the Gut Microbiota.	LDLR LEPR	3.03e-06	2	61	2	37762509
Pubmed	Osteoblastic Lrp4 promotes osteoclastogenesis by regulating ATP release and adenosine-A2AR signaling.	ADORA2A LRP4	3.03e-06	2	61	2	28193701
Pubmed	Hepatic NPC1L1 promotes hyperlipidemia in LDL receptor deficient mice.	NPC1L1 LDLR	3.03e-06	2	61	2	29601818
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	PIAS4 RNF113B RNF31 ZFP57 KLF3 ZFR FBLIM1 TRIM47 PIAS1	3.89e-06	709	61	9	22988430
Pubmed	Association study between candidate genes and obesity-related phenotypes using a sample of lumberjacks.	ADRB3 LDLR LEPR	4.11e-06	18	61	3	19367093
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	PIAS4 PCSK5 ERBB3 EHMT1 NSD1 DGKH ADAM12 PIAS1 LDLR	4.93e-06	730	61	9	34857952
Pubmed	Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients.	NPC1L1 SLCO1B1 LDLR LEPR	5.69e-06	66	61	4	20679960
Pubmed	Exome sequencing of two Italian pedigrees with non-isolated Chiari malformation type I reveals candidate genes for cranio-facial development.	DKK1 LRP4	9.07e-06	3	61	2	28513615
Pubmed	Protein Inhibitor of Activated STAT 1 (PIAS1) Protects Against Obesity-Induced Insulin Resistance by Inhibiting Inflammation Cascade in Adipose Tissue.	PIAS1 LEPR	9.07e-06	3	61	2	26324179
Pubmed	DNA break-induced sumoylation is enabled by collaboration between a SUMO ligase and the ssDNA-binding complex RPA.	PIAS4 PIAS1	9.07e-06	3	61	2	26253534
Pubmed	LEPR p.Q223R, beta3-AR p.W64R and LEP c.-2548G>A gene variants in obese Brazilian subjects.	ADRB3 LEPR	9.07e-06	3	61	2	18273796
Pubmed	Astrocytic Lrp4 (Low-Density Lipoprotein Receptor-Related Protein 4) Contributes to Ischemia-Induced Brain Injury by Regulating ATP Release and Adenosine-A2AR (Adenosine A2A Receptor) Signaling.	ADORA2A LRP4	9.07e-06	3	61	2	29212737
Pubmed	The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins.	LDLR PID1	9.07e-06	3	61	2	30100244
Pubmed	Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo.	DKK1 LRP4	9.07e-06	3	61	2	19936252
Pubmed	Apolipoprotein A-I and its role in lymphocyte cholesterol homeostasis and autoimmunity.	FAS LDLR	9.07e-06	3	61	2	19286630
Pubmed	PIASy interacts with p73alpha and regulates cell cycle in HEK293 cells.	PIAS4 PIAS1	9.07e-06	3	61	2	20471636
Pubmed	The Linear ubiquitin chain assembly complex acts as a liver tumor suppressor and inhibits hepatocyte apoptosis and hepatitis.	RNF31 FAS	9.07e-06	3	61	2	28120397
Pubmed	Roles of the SUMO-related enzymes, PIAS1, PIAS4, and RNF4, in DNA double-strand break repair by homologous recombination.	PIAS4 PIAS1	9.07e-06	3	61	2	35007836
Pubmed	Cloning and analysis of a murine PIAS family member, PIASgamma, in developing skin and neurons.	PIAS4 PIAS1	9.07e-06	3	61	2	10854042
Pubmed	Protein inhibitors of activated STAT (Pias1 and Piasy) differentially regulate pituitary homeobox 2 (PITX2) transcriptional activity.	PIAS4 PIAS1	9.07e-06	3	61	2	23515314
Pubmed	A Hepatic GAbp-AMPK Axis Links Inflammatory Signaling to Systemic Vascular Damage.	LDLR LEPR	9.07e-06	3	61	2	28793265
Pubmed	Control of specificity and magnitude of NF-kappa B and STAT1-mediated gene activation through PIASy and PIAS1 cooperation.	PIAS4 PIAS1	9.07e-06	3	61	2	17606919
Pubmed	Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice.	FAS LEPR	9.07e-06	3	61	2	19955656
Pubmed	PCSK9 deficiency reduces atherosclerosis, apolipoprotein B secretion, and endothelial dysfunction.	LDLR LEPR	9.07e-06	3	61	2	29180444
Pubmed	Redox regulation of MAPK phosphatase 1 controls monocyte migration and macrophage recruitment.	LDLR LEPR	9.07e-06	3	61	2	22991462
Pubmed	De novo lipogenesis maintains vascular homeostasis through endothelial nitric-oxide synthase (eNOS) palmitoylation.	FAS LEPR	1.81e-05	4	61	2	21098489
Pubmed	Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice.	LDLR LEPR	1.81e-05	4	61	2	17609370
Pubmed	The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis.	LDLR LEPR	1.81e-05	4	61	2	31391339
Pubmed	Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells.	PIAS4 PIAS1	1.81e-05	4	61	2	11439351
Pubmed	Dkk1 and MSX2-Wnt7b signaling reciprocally regulate the endothelial-mesenchymal transition in aortic endothelial cells.	DKK1 LDLR	1.81e-05	4	61	2	23685555
Pubmed	PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73.	PIAS4 PIAS1	1.81e-05	4	61	2	15572666
Pubmed	microRNA-30c reduces plasma cholesterol in homozygous familial hypercholesterolemic and type 2 diabetic mouse models.	LDLR LEPR	1.81e-05	4	61	2	29122890
Pubmed	Genetic variation and obesity in Australian women: a prospective study.	ADRB3 LEPR	1.81e-05	4	61	2	11743056
Pubmed	Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis.	LDLR LEPR	1.81e-05	4	61	2	17690315
Pubmed	Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans.	ADORA2A LEPR	1.81e-05	4	61	2	21270276
Pubmed	Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators.	PIAS4 PIAS1	1.81e-05	4	61	2	11877418
Pubmed	LEPR, ADBR3, IRS-1 and 5-HTT genes polymorphisms do not associate with obesity.	ADRB3 LEPR	1.81e-05	4	61	2	17124363
Pubmed	Adenosine receptor 2a agonists target mouse CD11c+T-bet+ B cells in infection and autoimmunity.	ADORA2A FAS	1.81e-05	4	61	2	35064115
Pubmed	Severe obesity is associated with novel single nucleotide polymorphisms of the ESR1 and PPARgamma locus in Han Chinese.	ADRB3 LDLR LEPR	2.46e-05	32	61	3	19491387
Pubmed	Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling.	ERBB3 DKK1 LRP4	2.96e-05	34	61	3	23293290
Pubmed	Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo.	DKK1 LRP4	3.02e-05	5	61	2	20383322
Pubmed	Genetic polymorphisms differently influencing the emergence of atrophy and fat accumulation in HIV-related lipodystrophy.	ADRB3 FAS	3.02e-05	5	61	2	18753860
Pubmed	Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding.	DKK1 LRP4	3.02e-05	5	61	2	16263759
Pubmed	ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome.	LDLR LEPR	3.02e-05	5	61	2	17084711
Pubmed	The clathrin adaptor proteins ARH, Dab2, and numb play distinct roles in Niemann-Pick C1-Like 1 versus low density lipoprotein receptor-mediated cholesterol uptake.	NPC1L1 LDLR	3.02e-05	5	61	2	25331956
Pubmed	PIAS proteins are involved in the SUMO-1 modification, intracellular translocation and transcriptional repressive activity of RET finger protein.	PIAS4 PIAS1	3.02e-05	5	61	2	15907835
Pubmed	Role of β-adrenergic receptors in the anti-obesity and anti-diabetic effects of zinc-α2-glycoprotien (ZAG).	ADRB3 LEPR	3.02e-05	5	61	2	22227600
Pubmed	Regulation of cardiac specific nkx2.5 gene activity by small ubiquitin-like modifier.	PIAS4 PIAS1	3.02e-05	5	61	2	18579533
Pubmed	Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis.	LDLR LEPR	3.02e-05	5	61	2	28604703
Pubmed	Activation of the SUMO modification system is required for the accumulation of RAD51 at sites of DNA damage.	PIAS4 PIAS1	3.02e-05	5	61	2	24046452
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	ERBB3 LDLR LEPR NOTCH3	3.08e-05	101	61	4	23382219
Pubmed	PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain.	PCSK5 LDLR	4.52e-05	6	61	2	20453200
Pubmed	Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet.	LDLR LEPR	4.52e-05	6	61	2	19834009
Pubmed	Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin.	ADRB3 LEPR	4.52e-05	6	61	2	24011077
Pubmed	Ubiquitin-SUMO circuitry controls activated fanconi anemia ID complex dosage in response to DNA damage.	PIAS4 PIAS1	4.52e-05	6	61	2	25557546
Pubmed	Notch controls the magnitude of T helper cell responses by promoting cellular longevity.	FAS NOTCH3	4.52e-05	6	61	2	22615412
Pubmed	A synaptic nidogen: developmental regulation and role of nidogen-2 at the neuromuscular junction.	NID2 LAMA5	4.52e-05	6	61	2	18817539
Pubmed	Repression of the Transactivating Capacity of the Oncoprotein PLAG1 by SUMOylation.	PIAS4 PIAS1	4.52e-05	6	61	2	15208321
Pubmed	SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage.	PIAS4 PIAS1	4.52e-05	6	61	2	22661230
Pubmed	A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription.	PIAS4 PIAS1	4.52e-05	6	61	2	20159969
Pubmed	Sleep modulates haematopoiesis and protects against atherosclerosis.	LDLR LEPR	4.52e-05	6	61	2	30760925
Pubmed	The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.	PIAS4 PIAS1	4.52e-05	6	61	2	20016594
Pubmed	A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.	RNF113B ZSWIM2 TRIM47 TRIM38	5.66e-05	118	61	4	19690564
Pubmed	A role for protein inhibitor of activated STAT1 (PIAS1) in lipogenic regulation through SUMOylation-independent suppression of liver X receptors.	PIAS1 LEPR	6.32e-05	7	61	2	22969086
Pubmed	Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice.	ADORA2A CYP4F12	6.32e-05	7	61	2	22160543
Pubmed	Inhibition of Stat1-mediated gene activation by PIAS1.	PIAS4 PIAS1	6.32e-05	7	61	2	9724754
Pubmed	SUMOylation of Csk Negatively Modulates its Tumor Suppressor Function.	PIAS4 PIAS1	6.32e-05	7	61	2	31125786
Pubmed	CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine.	ADORA2A LEPR	6.32e-05	7	61	2	29456159
Pubmed	The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice.	ADRB3 LEPR	6.32e-05	7	61	2	36243005
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	PIAS4 ZFP57 ZNF202 KLF3 ZNF740 ZFR FBLIM1 PIAS1	8.14e-05	808	61	8	20412781
Pubmed	Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism.	LDLR LEPR	8.42e-05	8	61	2	33462514
Pubmed	SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling.	PIAS4 PIAS1	8.42e-05	8	61	2	12223491
Pubmed	Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention Study.	ADRB3 LEPR	8.42e-05	8	61	2	18249219
Pubmed	Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1.	PIAS4 PIAS1	8.42e-05	8	61	2	20351170
Pubmed	Interaction of protein inhibitor of activated STAT (PIAS) proteins with the TATA-binding protein, TBP.	PIAS4 PIAS1	8.42e-05	8	61	2	16522640
Pubmed	Three-dimensional volume fluorescence-imaging of vascular plasticity in adipose tissues.	ADRB3 LEPR	8.42e-05	8	61	2	29914852
Pubmed	The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB.	PIAS4 PIAS1	1.08e-04	9	61	2	16816390
Pubmed	Identification of genetic variants associated with response to statin therapy.	SLCO1B1 LDLR	1.08e-04	9	61	2	19667110
Pubmed	Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain.	PIAS4 PIAS1	1.08e-04	9	61	2	17696781
Pubmed	Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5.	PIAS4 PIAS1	1.08e-04	9	61	2	21931855
Pubmed	CGI-55 interacts with nuclear proteins and co-localizes to p80-coilin positive-coiled bodies in the nucleus.	PIAS4 PIAS1	1.08e-04	9	61	2	16679534
Pubmed	An acetylation switch regulates SUMO-dependent protein interaction networks.	PIAS4 PIAS1	1.08e-04	9	61	2	22578841
Pubmed	Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks.	PIAS4 PIAS1	1.08e-04	9	61	2	20016603
Pubmed	Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City.	ADRB3 LEPR	1.35e-04	10	61	2	20503258
Pubmed	SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage.	PIAS4 PIAS1	1.35e-04	10	61	2	18408014
Pubmed	Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis.	ADRB3 LEPR	1.35e-04	10	61	2	35087060
Pubmed	Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort.	ADRB3 LEPR	1.35e-04	10	61	2	18426866
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PCSK5 ERBB3 RNF31 ELP1 PAPLN ZNFX1 PIAS1	1.40e-04	650	61	7	38777146
Pubmed	SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function.	PIAS4 PIAS1	1.65e-04	11	61	2	21965678
Pubmed	Sumoylation of FOXP2 Regulates Motor Function and Vocal Communication Through Purkinje Cell Development.	PIAS4 PIAS1	1.65e-04	11	61	2	27009683
Pubmed	HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells.	PIAS4 PIAS1	1.65e-04	11	61	2	28842558
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	PCSK5 NID2 SEPSECS RNF31 AFM	1.91e-04	302	61	5	30561431
Pubmed	Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis.	PIAS4 PIAS1	1.97e-04	12	61	2	30612578
Pubmed	LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L.	RNF31 FAS	1.97e-04	12	61	2	30254289
Pubmed	Foxp1 regulation of neonatal vocalizations via cortical development.	PIAS4 PIAS1	2.33e-04	13	61	2	29138280
Interaction	IGFL3 interactions	PCSK5 LRP4 LAMA5 LDLR NOTCH3	2.67e-06	75	59	5	int:IGFL3
Interaction	IGSF5 interactions	LRP4 LDLR NOTCH3	8.48e-06	14	59	3	int:IGSF5
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	PIAS4 CYP4F12 DENND1C QTRT1 LDLR NOTCH3	7.23e-04	797	62	6	chr19p13
GeneFamily	Zinc fingers MIZ-type	PIAS4 PIAS1	1.15e-04	7	43	2	85
GeneFamily	Laminin subunits	LAMB4 LAMA5	3.59e-04	12	43	2	626
GeneFamily	Low density lipoprotein receptors	LRP4 LDLR	4.24e-04	13	43	2	634
GeneFamily	Ring finger proteins	RFPL4B RNF113B RNF31 TRIM47 TRIM38	4.71e-04	275	43	5	58
GeneFamily	CD molecules\|Tumor necrosis factor receptor superfamily\|Death inducing signaling complex	TNFRSF12A FAS	2.15e-03	29	43	2	782
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	EHMT1 NSD1	2.95e-03	34	43	2	487
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF22 ZNF142 ZFP57 ZNF202 KLF3 ZNF740	6.69e-03	718	43	6	28
GeneFamily	LIM domain containing	MICAL2 FBLIM1	8.68e-03	59	43	2	1218
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM47 TRIM38	2.15e-02	95	43	2	59
Coexpression	NABA_BASEMENT_MEMBRANES	NID2 LAMB4 LAMA5 PAPLN	2.13e-06	40	60	4	M5887
Coexpression	LEE_LIVER_CANCER_DENA_UP	LY6D LAMA5 LEPR NOTCH3	1.10e-05	60	60	4	M16524
Coexpression	ONDER_CDH1_TARGETS_2_UP	NID2 ZNF22 MICAL2 ADAM12 PID1 LEPR	2.69e-05	257	60	6	M13867
Coexpression	GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_UP	FAS TRIM38 LEPR	2.86e-05	26	60	3	M14024
Coexpression	BROWNE_HCMV_INFECTION_14HR_DN	DKK1 MICAL2 MYO1B ZFR FAS LDLR	5.28e-05	290	60	6	M13251
Coexpression	GSE21360_NAIVE_VS_SECONDARY_MEMORY_CD8_TCELL_UP	SCARF1 MYO1B DGKH FAS PID1	6.28e-05	183	60	5	M7631
Coexpression	FAN_EMBRYONIC_CTX_BRAIN_ENDOTHELIAL_2	NID2 MYO1B DGKH ADAM12 PID1 NOTCH3	6.73e-05	303	60	6	M39040
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HPERIC	NID2 KLF3 MYO1B DGKH ADAM12 TRIM38 PID1 LEPR NOTCH3	7.68e-05	795	60	9	M39050
Coexpression	NABA_ECM_GLYCOPROTEINS	NID2 LAMB4 LAMA5 PAPLN SSPOP	8.69e-05	196	60	5	M3008
Coexpression	GSE20500_CTRL_VS_RETINOIC_ACID_TREATED_CD4_TCELL_DN	SCARF1 TNFRSF12A KLF3 MYO1B FAS	9.12e-05	198	60	5	M7701
Coexpression	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	TNFRSF12A NID2 DKK1 FAS ADAM12	9.56e-05	200	60	5	M5930
CoexpressionAtlas	dev gonad_e12.5_F_DevVasOvary_Flk_top-relative-expression-ranked_1000	SCARF1 ADORA2A NID2 ZFP57 LRP4 KLF3 MYO1B DGKH FAS ADAM12 LEPR	1.11e-05	817	58	11	gudmap_dev gonad_e12.5_F_gudmap_devVasOvary_Flk_1000
ToppCell	AT1_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	TNFRSF12A DKK1 MICAL2 LAMA5 MYO1B TRIM47 LDLR	7.76e-09	187	62	7	f1dda349335e08dbfc8395d373924037f5ad2fd6
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TNFRSF12A DKK1 MICAL2 AFM MYO1B LDLR	2.49e-07	188	62	6	2b8d70f761eda5509f21845a87cdb3602a639dd7
ToppCell	Biopsy_Other_PF-Epithelial-KRT5-/KRT17+\|Biopsy_Other_PF / Sample group, Lineage and Cell type	LY6D ERBB3 DKK1 SYT14 FBLIM1 NOTCH3	3.58e-07	200	62	6	077e6b9340686de9d0f11b035a8954e1f6a1b790
ToppCell	facs-Skin-Skin_Anagen-18m-Epithelial-epidermal_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LY6D LRP4 TRIM47 LDLR NOTCH3	4.30e-06	173	62	5	0f9c1d3298e59e6d22bb3306f0f445f490be8bbd
ToppCell	E15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PCSK5 ADORA2A FBLIM1 EGFL8 TRIM47	4.30e-06	173	62	5	b0ff9808e38cb64a734ced498cd0546728746cd5
ToppCell	(0)_Normal/No_Treatment-(3)_LEPR+_perivascular_cells\|World / Stress and Cell class	NID2 LRP4 PID1 LEPR NOTCH3	4.67e-06	176	62	5	ce2c32b5ce0da848eb4da35ce4d215cdf74d9113
ToppCell	AT1_cells-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	DKK1 MICAL2 LAMA5 MYO1B LDLR	4.81e-06	177	62	5	3128b8d04687acee1ac4190b2569d6328b98eaf3
ToppCell	droplet-Lung-nan-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID2 LRP4 MYO1B SSPOP NOTCH3	4.81e-06	177	62	5	65709bd546cb1ec6aa2ddd8b2adb46e174eb9a9a
ToppCell	droplet-Lung-nan-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID2 LRP4 MYO1B SSPOP NOTCH3	4.81e-06	177	62	5	8684d47a547e2a06496f15e8da0200ecddc431e0
ToppCell	COVID-19-kidney-REN+Pericyte\|kidney / Disease (COVID-19 only), tissue and cell type	MICAL2 MYO1B FBLIM1 ADAM12 NOTCH3	5.08e-06	179	62	5	342c1cc4444f51b8dcb30d3adc98285a25669c6e
ToppCell	AT1-AT2_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	LY6D DKK1 NPC1L1 SYT14 NOTCH3	5.22e-06	180	62	5	3c7b2033821f9e34e2924bd8655f566edcbcc7d3
ToppCell	P28-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADRB3 LRP4 MYO1B FBLIM1 PID1	5.80e-06	184	62	5	924400f47e6b2cdf7b0d538df75857935cf0209b
ToppCell	pdx-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	DKK1 LAMA5 MYO1B FBLIM1 LEPR	6.28e-06	187	62	5	7e376831a11ee72ed87abcdac631ca46ae29c250
ToppCell	facs-Skin-Telogen-3m-Epithelial-basal_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNFRSF12A LY6D TRIM47 FAS LDLR	6.28e-06	187	62	5	9c1013720c248ef201d010806b6e7ad24205e8ee
ToppCell	facs-Skin-Skin_Anagen-18m-Epithelial-Basal_IFE\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNFRSF12A LY6D LRP4 TRIM47 LDLR	6.61e-06	189	62	5	1cfc1fe27c4b57b4e52700fa8f679ce172cee5a9
ToppCell	facs-Skin-Skin_Anagen-18m-Epithelial-basal_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNFRSF12A LY6D LRP4 TRIM47 LDLR	6.78e-06	190	62	5	3639eb9b887a2d76949cad4a2586524fe0e1015f
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TNFRSF12A MICAL2 FBLIM1 TRIM47 NOTCH3	6.96e-06	191	62	5	9431ffd6b758f756609d9057de2023596e22b5d4
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADRB3 LRP4 MYO1B FBLIM1 PID1	6.96e-06	191	62	5	beb5bb42bd53bce01339da9110d374901548793c
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADRB3 LRP4 MYO1B FBLIM1 PID1	6.96e-06	191	62	5	6609d85fd2577633dcc067507304a6f9e5865ca3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 MICAL2 FBLIM1 ADAM12 PID1	6.96e-06	191	62	5	39092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 MICAL2 FBLIM1 ADAM12 PID1	6.96e-06	191	62	5	ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 MICAL2 FBLIM1 ADAM12 PID1	7.14e-06	192	62	5	d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCell	(0)_Normal/No_Treatment-(3)_LEPR+_perivascular_cells\|(0)_Normal/No_Treatment / Stress and Cell class	NID2 LRP4 PID1 LEPR NOTCH3	7.14e-06	192	62	5	7a2ad0bdae647b88e799e62767605f2f3c5a426f
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADRB3 LRP4 MYO1B FBLIM1 PID1	7.32e-06	193	62	5	027e098ad018e782287f84eee0f77551018f2196
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADRB3 LRP4 MYO1B FBLIM1 PID1	7.32e-06	193	62	5	c5463a87f20b3a7f7ffda677b2f5a0e9e49d6685
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_pericyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NID2 MICAL2 MYO1B ADAM12 NOTCH3	7.89e-06	196	62	5	cb61757646653f89faba503cb5d99e5dd5197b4c
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_pericyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NID2 MICAL2 MYO1B ADAM12 NOTCH3	7.89e-06	196	62	5	44e2df1b61e3819eae7e482bef0a733afe852d67
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 MICAL2 FBLIM1 ADAM12 PID1	8.08e-06	197	62	5	85a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 MICAL2 FBLIM1 ADAM12 PID1	8.08e-06	197	62	5	e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NID2 DKK1 MYO1B ADAM12 NOTCH3	8.08e-06	197	62	5	983502a99e6d59bb36225b0246a9990604de1a01
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MICAL2 MYO1B FBLIM1 ADAM12 PID1	8.08e-06	197	62	5	80e153790cef37b743e22a7370ff5b3a6abf147d
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_COL\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NID2 MICAL2 MYO1B FBLIM1 NOTCH3	8.28e-06	198	62	5	8b9e8eaeffda40912a0163fdf39b93bc5e64751c
ToppCell	Non-neuronal-Postmitotic-Endothelial\|World / Primary Cells by Cluster	SCARF1 NID2 MYO1B ADAM12 NOTCH3	8.49e-06	199	62	5	b9763ac9857a60db6f1f104fe1e9ea2266cf931b
ToppCell	Non-neuronal-Postmitotic-Endothelial-Endothelial-24\|World / Primary Cells by Cluster	SCARF1 NID2 MYO1B ADAM12 NOTCH3	8.49e-06	199	62	5	0b4edf3e359749827ef978a77b5267ddde732d71
ToppCell	Non-neuronal-Postmitotic-Endothelial-Endothelial\|World / Primary Cells by Cluster	SCARF1 NID2 MYO1B ADAM12 NOTCH3	8.49e-06	199	62	5	9e01eee126247a0696c71b019f855a8a41a0ede3
ToppCell	Posterior_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Acta2Rgs5.Abcc9_(Mural.Acta2Rgs5.Abcc9)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ADORA2A FBLIM1 LEPR NOTCH3	2.88e-05	126	62	4	2b06adfb00a557bd90ad93719548a49f9ae9edeb
ToppCell	Posterior_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Acta2Rgs5.Abcc9_(Mural.Acta2Rgs5.Abcc9)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ADORA2A FBLIM1 LEPR NOTCH3	2.88e-05	126	62	4	43e7b226a195ab2068518b3a9ffd2192129e8ae4
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LY6D ZFP57 MYO1B FBLIM1	5.55e-05	149	62	4	7e295b2b82dea0754e98f8cef788e2781e5d641f
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LY6D ZFP57 MYO1B FBLIM1	5.55e-05	149	62	4	b4f77dc5f9d08b249fe5cd9a0acf86308c528ef4
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Spp1_(Entopeduncular_Nucleus_(Ent)_or_Zona_Incerta,_ventral_part_(ZIV)._State_signal?)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	ADRB3 RUBCNL DENND1C	5.88e-05	54	62	3	98b31718fa200432cf86b59a52484da101219f96
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Spp1_(Entopeduncular_Nucleus_(Ent)_or_Zona_Incerta,_ventral_part_(ZIV)._State_signal?)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	ADRB3 RUBCNL DENND1C	5.88e-05	54	62	3	872e7374dac64be2c8ebe71e88a2ec6814168d89
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-SMC_prolif-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NID2 MYO1B ADAM12 NOTCH3	6.97e-05	158	62	4	32c95c1bc9e50fccd6d06e828f29258fc5e568cb
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	ERBB3 LAMA5 ZNF202 MYO1B	7.68e-05	162	62	4	2259e9536147e9cdee772e3a30ba7d104573262c
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ERBB3 LAMA5 ZNF202 MYO1B	8.44e-05	166	62	4	89e2b8453180983533faccb4275867861876d7ee
ToppCell	356C-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	NSD1 PAPLN ZNFX1 LDLR	9.04e-05	169	62	4	0425d2580ed325178f522c0093ff4623de6ce7a8
ToppCell	356C-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	NSD1 PAPLN ZNFX1 LDLR	9.04e-05	169	62	4	fec669968a77060bd77ee8695034e35a642c984f
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-mLTo\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PAPLN TRIM47 ADAM12 NOTCH3	9.04e-05	169	62	4	559e98216720e4babf0b0941100f1b485c35b11b
ToppCell	normal_Lung-Fibroblasts-Pericytes\|Fibroblasts / Location, Cell class and cell subclass	MYO1B DGKH DISP1 NOTCH3	9.25e-05	170	62	4	d69c0ea4cb6b204f19d0a5d2164afb42184779ac
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PAPLN DGKH ADAM12 NOTCH3	9.25e-05	170	62	4	5570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell	facs-Heart-LV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IQSEC3 MYO1B SSPOP NOTCH3	9.90e-05	173	62	4	d78397e65e997ddb995111a810f0e2a4f67d0765
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	MICAL2 ZFP57 DGKH ADAM12	9.90e-05	173	62	4	efb8072475000888efe088d00e870c56ffad4172
ToppCell	facs-Heart-LV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IQSEC3 MYO1B SSPOP NOTCH3	9.90e-05	173	62	4	3c852ffe22f4a5b632463086b08c669310684e80
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TNFRSF12A MICAL2 TRIM47 NOTCH3	1.01e-04	174	62	4	778e0317c0c63fa4efd74114feb760975b819d92
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LY6D LAMA5 LDLR NOTCH3	1.01e-04	174	62	4	207aa0118633cbe9a65839bbb1bb3ba9f8118ad2
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MICAL2 ZFP57 DGKH ADAM12	1.01e-04	174	62	4	58300d64d3b6fd9ba1b6c87ea83b2777eb6be2f4
ToppCell	COVID-19_Convalescent\|World / Disease Group and Platelet Clusters	ADORA2A ZNF142 SMCR5 QTRT1	1.03e-04	175	62	4	e9b1faa4c85537f30306619a2f3ada6c8ef0ac6c
ToppCell	AT1_cells-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	TNFRSF12A LAMA5 MYO1B LDLR	1.06e-04	176	62	4	4a30bb771297b30926fb98e2b5ec0dbdc46feac7
ToppCell	facs-Heart-RV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADORA2A IQSEC3 MYO1B NOTCH3	1.08e-04	177	62	4	7c3d46ebd7e8726be6871aa9763e281fc0ec6ac8
ToppCell	facs-Heart-RV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADORA2A IQSEC3 MYO1B NOTCH3	1.08e-04	177	62	4	e7b1f3092e6b8d0d580f82648035f5ad12be6961
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NID2 MYO1B DGKH NOTCH3	1.10e-04	178	62	4	185b44700f06ec58b3c09c80520502166c965fd6
ToppCell	3'_v3-Lung-Myeloid_Mac-Erythrophagocytic_macrophages\|Lung / Manually curated celltypes from each tissue	SCARF1 TRIM47 PID1 NOTCH3	1.10e-04	178	62	4	b63cee443cc1b7416112bf610d7c9d41e4fa37ed
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-SMC_prolif\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NID2 MYO1B ADAM12 NOTCH3	1.15e-04	180	62	4	64956a85c404a2ea7e4eaf6f95ebcc52c198b7cc
ToppCell	facs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PCSK5 MICAL2 SYT14 TRIM47	1.15e-04	180	62	4	67c5068b660cd5e727a665cefe3bd5f8ae887221
ToppCell	facs-Heart-LV-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IQSEC3 MYO1B SSPOP NOTCH3	1.18e-04	181	62	4	1db1eb7d330a7e5090994007ae287e11f0a74450
ToppCell	facs-Heart-LV-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IQSEC3 MYO1B SSPOP NOTCH3	1.18e-04	181	62	4	06174ce9240c9261c0f51a1b0d875335d60722e5
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 MICAL2 ZFP57 TRIM47	1.18e-04	181	62	4	4ea02344e1996f264dd5e14f3b19c8782ce41699
ToppCell	facs-Lung-nan-3m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM163B MYO1B FBLIM1 PID1	1.20e-04	182	62	4	c557de6ccd327c46e0a5423cd9936d78e0abae5f
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NID2 MYO1B ADAM12 NOTCH3	1.20e-04	182	62	4	fc4a5bf784705efe7965ce43ac23c2a8e602e90a
ToppCell	facs-Lung-18m-Endothelial-arterial_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PCSK5 MICAL2 SYT14 TRIM47	1.20e-04	182	62	4	ebc812ed3f25839ea25f76b952c463d79a8325b1
ToppCell	facs-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM163B MYO1B FBLIM1 PID1	1.20e-04	182	62	4	dbe4b2557cf19e0682ed446f8397d3a1153642f0
ToppCell	P28-Mesenchymal\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	LRP4 MYO1B FBLIM1 PID1	1.20e-04	182	62	4	69f9d44694fe4f55a971ae0ac5dc3e7448ee78f3
ToppCell	facs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PCSK5 MICAL2 SYT14 TRIM47	1.20e-04	182	62	4	47ff6b4002a4167412c79210651316d1342503f9
ToppCell	IPF-Epithelial-ATI\|World / Disease state, Lineage and Cell class	TNFRSF12A DKK1 LAMA5 MYO1B	1.23e-04	183	62	4	31fef35ecf30162662f24d335d8f0cceacc07039
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PAPLN MYO1B DGKH NOTCH3	1.23e-04	183	62	4	8a799807fbf24456a9811e0c64068187940a2f71
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MICAL2 FBLIM1 TRIM47 NOTCH3	1.23e-04	183	62	4	b4f29dd3994009bb5eb769d36d95886664e7f87d
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-Late_airway_progenitor\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	LY6D ERBB3 NPC1L1 LAMA5	1.23e-04	183	62	4	0cea883a8a79fc58abcb26b08bf5db9d3d60f7d4
ToppCell	IPF-Epithelial-ATI\|IPF / Disease state, Lineage and Cell class	TNFRSF12A DKK1 LAMA5 MYO1B	1.23e-04	183	62	4	c0a3541c45bd0c587603521f392f42dd86c3c35b
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PAPLN MYO1B ADAM12 NOTCH3	1.25e-04	184	62	4	327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ERBB3 AFM ELP1 PID1	1.28e-04	185	62	4	1d874608aa2062024323512f68889219471b2f00
ToppCell	(1)_Control_(PBS)-(2)_LEPR+_perivascular_cells_and_VE-Cad+_vascular_cells_(mixed)\|World / Stress and Cell class	LRP4 PID1 LEPR NOTCH3	1.28e-04	185	62	4	b8cd94cf18308b514fc61557550225794ffd2860
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PCSK5 MICAL2 FBLIM1 TRIM47	1.31e-04	186	62	4	c116cc9f41971622264434ebe29d18e719b0ae19
ToppCell	PCW_07-8.5-Neuronal\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ERBB3 RUBCNL SYT14 ADAM12	1.31e-04	186	62	4	7a4bb42f3f6a27b463e48eafc587d9ab3386f2fb
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADRB3 MYO1B FBLIM1 PID1	1.31e-04	186	62	4	88e6246172d816806a498a5c1f38e699f2f5d7c2
ToppCell	PCW_05-06-Neuronal\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ERBB3 RUBCNL SYT14 ADAM12	1.34e-04	187	62	4	03a2ed85b171c887d4f3b0f4fe2e1cb4a853e658
ToppCell	P07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PCSK5 KLF3 EGFL8 TRIM47	1.36e-04	188	62	4	5bc1537e079c7435196c163bff5f639ea392a33a
ToppCell	droplet-Lung-nan-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 MICAL2 LAMA5 TRIM47	1.36e-04	188	62	4	405efea75233ecf70f7d19b630230798d817b7f2
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MICAL2 LAMA5 TRIM38 NOTCH3	1.36e-04	188	62	4	a5e7a363fbd5ae4d9312cf6f9941413d6a5c0b4d
ToppCell	facs-Skin-Telogen-3m-Epithelial-Basal_IFE\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LY6D LRP4 TRIM47 FAS	1.36e-04	188	62	4	8cc927b4c51d982fdafa04dc7393617ad9bb220e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 FBLIM1 ADAM12 PID1	1.39e-04	189	62	4	71397e993a77d70b2eeede240bdfc7660b558987
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NID2 FBLIM1 ADAM12 PID1	1.39e-04	189	62	4	4eea4759520c312bd17a681034d8074e47093d2b
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCARF1 PCSK5 EGFL8 TRIM47	1.39e-04	189	62	4	feedac2751ed770f80bc56fec31662b5b3826f58
ToppCell	IPF-Epithelial-Aberrant_Basaloid\|Epithelial / Disease state, Lineage and Cell class	TNFRSF12A MICAL2 SYT14 FBLIM1	1.39e-04	189	62	4	4178be3292ff4a8a1d8098f638d4b8d15164d2c6
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TNFRSF12A MICAL2 MYO1B LDLR	1.39e-04	189	62	4	e90ba6f6d7ba0698d04d84278aa035c28803733e
ToppCell	AT2_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	SCARF1 MICAL2 MYO1B PID1	1.39e-04	189	62	4	2d32f09efa982ae458568f6b1cd06bb5078d42a3
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADRB3 LRP4 MYO1B FBLIM1	1.39e-04	189	62	4	e76dc36a01d8ad7590b3acc4c46abfcb76857448
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NID2 MYO1B LEPR NOTCH3	1.42e-04	190	62	4	7e4d80a3a7f83b6a50f1d0fe82fb6c242c39d5b0
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TNFRSF12A DKK1 MYO1B LDLR	1.42e-04	190	62	4	8ceb327dc995f4b83b05d5d6630e1294f0cb49bd
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NID2 MYO1B DGKH NOTCH3	1.42e-04	190	62	4	4eb92aef1ee868f4537483d19014d947b7684612
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TNFRSF12A MICAL2 LAMA5 MYO1B	1.42e-04	190	62	4	30b50d183d7649146eb1e79b47ba897355f1998a
ToppCell	P03-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	LRP4 MYO1B LEPR NOTCH3	1.42e-04	190	62	4	979b1476fd2692fde977ce56257315fcfc8a01d5
Drug	Toxins, Biological	NID2 ERBB3 DKK1 LAMA5 KLF3 MYO1B FAS ADAM12 PIAS1 LDLR	5.46e-06	632	60	10	ctd:D014118
Drug	epicholesterol	SCARF1 ERBB3 ADRB3 NPC1L1 LRP4 ZNF202 ZFR FAS SLCO1B1 LDLR	5.77e-06	636	60	10	CID000000304
Disease	Lipidemias	ADRB3 LDLR LEPR	5.33e-06	17	60	3	C1706412
Disease	Hyperlipidemia	ADRB3 LDLR LEPR	5.33e-06	17	60	3	C0020473
Disease	Malignant neoplasm of breast	NID2 ERBB3 ZNF22 DKK1 EHMT1 ELP1 ADAM12 SLCO1B1 LEPR NOTCH3	5.64e-05	1074	60	10	C0006142
Disease	Nephritis	FAS LEPR	1.45e-04	9	60	2	C0027697
Disease	Tremor	ADORA2A ZNF142	2.21e-04	11	60	2	C0040822
Disease	hematologic cancer (implicated_via_orthology)	PIAS4 PIAS1	3.13e-04	13	60	2	DOID:2531 (implicated_via_orthology)
Disease	response to statin, LDL cholesterol change measurement	SLCO1B1 LDLR	4.20e-04	15	60	2	EFO_0007804, GO_0036273
Disease	juvenile idiopathic arthritis	LAMB4 FAS PID1	4.68e-04	74	60	3	EFO_0002609
Disease	non-alcoholic fatty liver disease (is_implicated_in)	ADRB3 LEPR	6.09e-04	18	60	2	DOID:0080208 (is_implicated_in)
Disease	Drug toxicity	ADORA2A AFM SLCO1B1	6.77e-04	84	60	3	C0013221
Disease	Adverse reaction to drug	ADORA2A AFM SLCO1B1	6.77e-04	84	60	3	C0041755
Disease	Mammary Carcinoma, Human	ERBB3 DKK1 ELP1 SLCO1B1 LEPR NOTCH3	6.84e-04	525	60	6	C4704874
Disease	Mammary Neoplasms, Human	ERBB3 DKK1 ELP1 SLCO1B1 LEPR NOTCH3	6.84e-04	525	60	6	C1257931
Disease	Mammary Neoplasms	ERBB3 DKK1 ELP1 SLCO1B1 LEPR NOTCH3	6.98e-04	527	60	6	C1458155
Disease	cortisol measurement	DGKH LDLR	7.55e-04	20	60	2	EFO_0005843
Disease	Breast Carcinoma	ERBB3 DKK1 ELP1 SLCO1B1 LEPR NOTCH3	7.77e-04	538	60	6	C0678222
Disease	sleep duration, low density lipoprotein cholesterol measurement	NPC1L1 QTRT1 LDLR	8.55e-04	91	60	3	EFO_0004611, EFO_0005271
Disease	Dyslipidemias	LDLR LEPR	1.09e-03	24	60	2	C0242339
Disease	Dyslipoproteinemias	LDLR LEPR	1.09e-03	24	60	2	C0598784
Disease	primary biliary cholangitis (is_marker_for)	FAS LEPR	1.18e-03	25	60	2	DOID:12236 (is_marker_for)
Disease	Weight Gain	SEPSECS MYO1B LEPR	1.19e-03	102	60	3	C0043094
Disease	Streptozotocin Diabetes	ADRB3 FAS LEPR	1.40e-03	108	60	3	C0038433
Disease	Diabetes Mellitus, Experimental	ADRB3 FAS LEPR	1.40e-03	108	60	3	C0011853
Disease	Alloxan Diabetes	ADRB3 FAS LEPR	1.40e-03	108	60	3	C0002152
Disease	chronic obstructive pulmonary disease (biomarker_via_orthology)	ERBB3 FAS	1.49e-03	28	60	2	DOID:3083 (biomarker_via_orthology)
Disease	free cholesterol measurement	NPC1L1 LDLR LEPR	1.60e-03	113	60	3	EFO_0008591
Disease	total cholesterol measurement, low density lipoprotein cholesterol measurement	NPC1L1 LDLR LEPR	1.64e-03	114	60	3	EFO_0004574, EFO_0004611
Disease	intestinal cancer (implicated_via_orthology)	ERBB3 NOTCH3	1.94e-03	32	60	2	DOID:10155 (implicated_via_orthology)
Disease	Diabetes Mellitus	ZFP57 LEPR	1.94e-03	32	60	2	C0011849

Protein segments in the cluster

Peptide	Gene	Start	Entry
TDCFACRHFNDSGAC	ERBB3	241	P21860
DECRTSITLCSHHCF	EGFL8	146	Q99944
CDSKCCHPSNFIIEA	CCDC62	511	Q6P9F0
IINCFTFFCPDCSHA	ADORA2A	251	P29274
DHCCKTNFAFRRPCF	AFM	496	P43652
ACRDSSNSCDLPEFC	ADAM12	481	O43184
AQRCHSNPRCCAFAS	ADRB3	186	P13945
CPDCTPRVLCNFHTF	C7orf31	356	Q8N865
QSLDCCHRGDLDSCF	DENND1C	581	Q8IV53
VCHFFSLNQRCSCPD	DISP1	1261	Q96F81
CCDSCPAAFHRECLN	NSD1	1721	Q96L73
FHKQCFQSSECPRCA	RUBCNL	631	Q9H714
APRHFCRCACFCTDN	OGFOD2	6	Q6N063
QCPDCDRSFSRSDHL	KLF3	321	P57682
CEDTAFLPSKCCSSH	PID1	11	Q7Z2X4
TCTEFHNCTECRDGL	PCSK5	746	Q92824
CSSPACLYDNFDCHA	NOTCH3	1446	Q9UM47
TFHCCFRSEQDRNCS	LEPR	86	P48357
HSHTCQCFCLRDASF	ELP1	656	O95163
QAELSCPVCLDFFSC	RFPL4B	6	Q6ZWI9
DSPHVCRRCNCESDF	LAMA5	421	O15230
CSHARPTFCNVCRES	DGKH	181	Q86XP1
HQFCCPAADACSDLA	IQSEC3	191	Q9UPP2
CSENRCHPAATCYNT	NID2	896	Q14112
TRCPACSDNFVNLHC	NPC1L1	111	Q9UHC9
CRSCSHCEPPTFFLQ	FAM163B	91	P0C2L3
CIFSFDSHCQERPSE	CYP4F12	206	Q9HCS2
NCKHSVVCPASSRFC	LY6D	31	Q14210
AFHPSCFTCVTCARC	FBLIM1	261	Q8WUP2
SQEFPTCLQCHLCFD	LAMB4	1166	A4D0S4
CCVSPFFCHSQTDLL	FAM237A	26	A0A1B0GTK4
RSSDCASGLCCARHF	DKK1	191	O94907
DCASRVNNASYCPHC	EHMT1	616	Q9H9B1
FFHRECFRCSICATT	MICAL2	1021	O94851
TFCCPQCRAPFHMDS	TRIM38	56	O00635
ALSCLSCLASFCPAH	TRIM47	141	Q96LD4
DSKCEFSHCSNSPRC	SYT14	186	Q8NB59
FSHCSNSPRCSYNKC	SYT14	191	Q8NB59
ECTCPTCQKHSRAFL	QTRT1	316	Q9BXR0
HFRPCLISNCSEDSC	SSPOP	4411	A2VEC9
CFASLFHLCCISVDR	TAAR9	116	Q96RI9
CESCALEHFRATPRC	RNF113B	276	Q8IZP6
LASSCFEQHSCFSPR	SMCR5	16	Q8TEV8
RFCLSETSCPQEDHF	PIAS1	201	O75925
CRALTCSHLQCFDAT	PIAS1	346	O75925
HRDVPLSYCNSDCNC	SLCO1B1	451	Q9Y6L6
SFRCNCHGSPCEQDS	SCARF1	191	Q14162
DCRTHFLSCNDPTFC	TEX51	116	A0A1B0GUA7
SCECTICPDCFRQHF	RNF31	716	Q96EP0
RLNVFCCPHCSLTFS	ZFP57	296	Q9NU63
PNFFCNSTVCEHCDP	FAS	131	P25445
FCCASCSRFQPHAQP	PAPLN	1261	O95428
PCRAETCAHLQCFDA	PIAS4	336	Q8N2W9
SCFEGRFHERCQQPC	ZNFX1	1451	Q9P2E3
CFDSCCHLSHTFTFR	ZSWIM2	261	Q8NEG5
RFHCKLCECSFNDPN	ZFR	581	Q96KR1
CDECGRCFSQSSHLI	ZNF22	141	P17026
DCASCRARPHSDFCL	TNFRSF12A	51	Q9NP84
CILCIHSTTSCFAPR	SEPSECS	216	Q9HD40
FHCNSCPFLCSRLSS	ZNF142	1026	P52746
CPFCDFTCRHQLVLD	ZNF142	1426	P52746
PYQCERCHQCFSRTD	ZNF740	156	Q8NDX6
LCSECGRCFTHSAAF	ZNF202	566	O95125
CAVATCRPDEFQCSD	LDLR	231	P01130
HLCFARASDFVCACP	LRP4	1626	O75096
CSRFLNDTSLPHSCF	MYO1B	496	O43795