Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	potassium:proton antiporter activity	SLC9A9 SLC9A7 SLC9A6	1.34e-05	14	68	3	GO:0015386
GeneOntologyMolecularFunction	sodium:proton antiporter activity	SLC9A9 SLC9A7 SLC9A6	2.05e-05	16	68	3	GO:0015385
GeneOntologyMolecularFunction	solute:potassium antiporter activity	SLC9A9 SLC9A7 SLC9A6	3.52e-05	19	68	3	GO:0022821
GeneOntologyMolecularFunction	metal cation:proton antiporter activity	SLC9A9 SLC9A7 SLC9A6	1.04e-04	27	68	3	GO:0051139
GeneOntologyMolecularFunction	metal cation:monoatomic cation antiporter activity	SLC9A9 SLC9A7 SLC9A6	4.23e-04	43	68	3	GO:0140828
Domain	Na/H_exchanger_6	SLC9A9 SLC9A7 SLC9A6	4.62e-08	3	68	3	IPR002090
Domain	NaH_exchanger	SLC9A9 SLC9A7 SLC9A6	3.82e-06	9	68	3	IPR004709
Domain	Cation/H_exchanger_CPA1	SLC9A9 SLC9A7 SLC9A6	7.46e-06	11	68	3	IPR018422
Domain	Na_H_Exchanger	SLC9A9 SLC9A7 SLC9A6	1.63e-05	14	68	3	PF00999
Domain	Cation/H_exchanger	SLC9A9 SLC9A7 SLC9A6	1.63e-05	14	68	3	IPR006153
Domain	LUC7	LUC7L LUC7L2	3.91e-05	3	68	2	PF03194
Domain	Luc7-rel	LUC7L LUC7L2	3.91e-05	3	68	2	IPR004882
Domain	KRAB	ZNF599 ZNF17 ZNF845 ZNF527 ZNF154 ZNF529 ZNF114 ZNF707	4.57e-05	358	68	8	PS50805
Domain	KRAB	ZNF599 ZNF17 ZNF845 ZNF527 ZNF154 ZNF529 ZNF114 ZNF707	4.57e-05	358	68	8	PF01352
Domain	KRAB	ZNF599 ZNF17 ZNF845 ZNF527 ZNF154 ZNF529 ZNF114 ZNF707	5.66e-05	369	68	8	SM00349
Domain	KRAB	ZNF599 ZNF17 ZNF845 ZNF527 ZNF154 ZNF529 ZNF114 ZNF707	5.77e-05	370	68	8	IPR001909
Domain	ZINC_FINGER_C2H2_2	ZNF599 ZNF16 ZNF17 ZNF845 ZNF527 ZNF154 ARID2 ZNF451 ZNF529 ZNF114 ZNF707	1.03e-04	775	68	11	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF599 ZNF16 ZNF17 ZNF845 ZNF527 ZNF154 ARID2 ZNF451 ZNF529 ZNF114 ZNF707	1.06e-04	777	68	11	PS00028
Domain	Znf_C2H2-like	ZNF599 ZNF16 ZNF17 ZNF845 ZNF527 ZNF154 ARID2 ZNF451 ZNF529 ZNF114 ZNF707	1.31e-04	796	68	11	IPR015880
Domain	Znf_C2H2	ZNF599 ZNF16 ZNF17 ZNF845 ZNF527 ZNF154 ARID2 ZNF451 ZNF529 ZNF114 ZNF707	1.44e-04	805	68	11	IPR007087
Domain	ZnF_C2H2	ZNF599 ZNF16 ZNF17 ZNF845 ZNF527 ZNF154 ARID2 ZNF451 ZNF529 ZNF114 ZNF707	1.49e-04	808	68	11	SM00355
Domain	zf-C2H2	ZNF599 ZNF16 ZNF17 ZNF845 ZNF527 ZNF154 ZNF451 ZNF529 ZNF114 ZNF707	1.93e-04	693	68	10	PF00096
Domain	-	ZNF599 ZNF16 ZNF17 ZNF845 ZNF527 ZNF154 ZNF529 ZNF114 ZNF707	7.62e-04	679	68	9	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF599 ZNF16 ZNF17 ZNF845 ZNF527 ZNF154 ZNF529 ZNF114 ZNF707	8.90e-04	694	68	9	IPR013087
Domain	zf-C2H2_6	ZNF16 ZNF17 ZNF845 ZNF527 ZNF154 ZNF114	9.82e-04	314	68	6	PF13912
Domain	Myotubularin-like_Pase_dom	MTMR11 MTMR2	1.16e-03	14	68	2	IPR010569
Domain	PPASE_MYOTUBULARIN	MTMR11 MTMR2	1.16e-03	14	68	2	PS51339
Domain	Myotubularin_fam	MTMR11 MTMR2	1.16e-03	14	68	2	IPR030564
Domain	Myotub-related	MTMR11 MTMR2	1.16e-03	14	68	2	PF06602
Domain	LisH	MAEA TBL1X	4.64e-03	28	68	2	SM00667
Domain	LisH	MAEA TBL1X	4.64e-03	28	68	2	IPR006594
Domain	LISH	MAEA TBL1X	4.64e-03	28	68	2	PS50896
Domain	UBA	USP13 VPS13D	5.32e-03	30	68	2	SM00165
Pathway	REACTOME_SODIUM_PROTON_EXCHANGERS	SLC9A9 SLC9A7 SLC9A6	3.07e-06	9	48	3	M27337
Pathway	REACTOME_SODIUM_PROTON_EXCHANGERS	SLC9A9 SLC9A7 SLC9A6	3.07e-06	9	48	3	MM15079
Pubmed	Organellar Na+/H+ exchangers: novel players in organelle pH regulation and their emerging functions.	SLC9A9 SLC9A7 SLC9A6	2.99e-08	4	69	3	21171650
Pubmed	Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation.	SLC9A9 SLC9A7 SLC9A6	7.45e-08	5	69	3	15522866
Pubmed	Genes for endosomal pH regulators NHE6 and NHE9 are dysregulated in the substantia nigra in Parkinson's disease.	SLC9A9 SLC9A6	3.88e-06	2	69	2	38945311
Pubmed	A membrane-proximal region in the C-terminal tail of NHE7 is required for its distribution in the trans-Golgi network, distinct from NHE6 localization at endosomes.	SLC9A7 SLC9A6	3.88e-06	2	69	2	20364249
Pubmed	A genetic association study of CSMD1 and CSMD2 with cognitive function.	CSMD1 CSMD2	3.88e-06	2	69	2	27890662
Pubmed	Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network.	SLC9A7 SLC9A6	3.88e-06	2	69	2	11279194
Pubmed	The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia.	CSMD1 CSMD2	3.88e-06	2	69	2	21439553
Pubmed	Loss of CSMD1 or 2 may contribute to the poor prognosis of colorectal cancer patients.	CSMD1 CSMD2	3.88e-06	2	69	2	24408017
Pubmed	Vestibular hair bundles control pH with (Na+, K+)/H+ exchangers NHE6 and NHE9.	SLC9A9 SLC9A6	3.88e-06	2	69	2	17005858
Pubmed	Genes for endosomal NHE6 and NHE9 are misregulated in autism brains.	SLC9A9 SLC9A6	3.88e-06	2	69	2	23508127
Pubmed	Macropinocytosis and TAK1 mediate anti-inflammatory to pro-inflammatory macrophage differentiation by HIV-1 Nef.	SLC9A9 SLC9A7 SLC9A6	5.97e-06	18	69	3	24874739
Pubmed	Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms.	LUC7L LUC7L2	1.16e-05	3	69	2	33852859
Pubmed	Identification of two new members of the CSMD gene family.	CSMD1 CSMD2	1.16e-05	3	69	2	12906867
Pubmed	Cell surface levels of organellar Na+/H+ exchanger isoform 6 are regulated by interaction with RACK1.	SLC9A9 SLC9A6	1.16e-05	3	69	2	18057008
Pubmed	Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population.	VPS13D CSMD1	1.16e-05	3	69	2	20610895
Pubmed	Identification of proteins binding to E-Box/Ku86 sites and function of the tumor suppressor SAFB1 in transcriptional regulation of the human xanthine oxidoreductase gene.	OSM SAFB	1.16e-05	3	69	2	18772145
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF17 ZNF845 MAEA ZNF529 ZNF707	3.10e-05	181	69	5	37372979
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	USP13 OGT GLB1 LUC7L2 TARS2 ANKRD27 IQGAP3 PLCE1	4.37e-05	650	69	8	38777146
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	MIER2 LUC7L VPS13D GLB1 ARID2 WDR73 AHDC1	9.60e-05	538	69	7	10512203
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	MIER2 FBXO38 KDM3A ZNF845 OGT ARID2 ZNF451	2.04e-04	608	69	7	36089195
Pubmed	Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions.	MTMR11 MTMR2	2.53e-04	12	69	2	16787938
Pubmed	Protocadherins.	PCDHB6 PCDHB16	2.98e-04	13	69	2	12231349
Pubmed	Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development.	SLC9A9 SLC9A6	4.01e-04	15	69	2	24035762
Pubmed	Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.	THG1L LTA4H TSSC4 HEXIM2 TBL1X	5.10e-04	330	69	5	21044950
Pubmed	Interaction network of human early embryonic transcription factors.	OGT ARID2 MCM3AP AHDC1 TBL1X	6.74e-04	351	69	5	38297188
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	LUC7L OGT MAEA SLC9A7 CSMD1 TARS2 AHDC1 PCDHB16 HEXIM2 TBL1X	6.83e-04	1489	69	10	28611215
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	MIER2 VPS13D GLB1 ARID2 WDR73 AHDC1	6.87e-04	536	69	6	15840001
Pubmed	The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number.	PCDHB6 PCDHB16	7.20e-04	20	69	2	11322959
Pubmed	Hereditary Ataxia Overview	VPS13D WDR73 SLC9A6	8.27e-04	92	69	3	20301317
Pubmed	Microarray expression profiling of tissues from mice with uniparental duplications of chromosomes 7 and 11 to identify imprinted genes.	ZRSR2 TSSC4	1.04e-03	24	69	2	11668390
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	SAFB LUC7L2 ARID2 GOLGA3 HEXIM2	1.08e-03	390	69	5	17643375
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ARID2 ZNF529 PCDHB16	1.08e-03	101	69	3	10997877
Pubmed	Functional proteomics mapping of a human signaling pathway.	USP13 MTMR11 LUC7L2 ZNF451 MCM3AP ANKRD27	1.14e-03	591	69	6	15231748
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZNF451 MCM3AP SLC9A6 PCDHB16 PLCE1	1.30e-03	407	69	5	12693553
Pubmed	The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.	FBXO38 PEBP1	1.32e-03	27	69	2	28007894
Pubmed	The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.	FBXO38 OGT MCM3AP TBL1X	1.45e-03	245	69	4	19521500
Pubmed	FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.	USP36 LUC7L SAFB LUC7L2	1.52e-03	248	69	4	27926873
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	OSM SAFB GLB1 LUC7L2 MCM3AP WDR73 TSSC4 MAPKAPK5	1.70e-03	1124	69	8	21900206
Pubmed	Multiple genes encoding zinc finger domains are expressed in human T cells.	ZNF16 ZNF17	1.74e-03	31	69	2	2288909
Pubmed	Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin.	USP36 USP13	1.97e-03	33	69	2	30323974
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF599 ZNF17 ZNF845 ZNF527 ZNF154 PRR19 KIR2DL3 ANKRD27 ZNF529 ZNF114	1.14e-05	1192	69	10	chr19q13
Cytoband	19q13.4	ZNF17 ZNF154 KIR2DL3	2.37e-04	79	69	3	19q13.4
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF599 ZNF16 ZNF17 ZNF845 ZNF527 ZNF154 ZNF451 ZNF529 ZNF114 ZNF707	1.02e-05	718	46	10	28
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	MTMR11 MTMR2	6.51e-04	15	46	2	903
Coexpression	GSE40274_HELIOS_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_DN	USP36 SLC9A9 ZRSR2 SEMA4A TBL1X PLCE1	1.31e-05	199	68	6	M9168
Disease	survival time, breast carcinoma	KCNH7 TBL1X	3.90e-04	13	67	2	EFO_0000305, EFO_0000714
Disease	lysophosphatidylethanolamine 16:0 measurement	NXPE2 GNAO1	1.59e-03	26	67	2	EFO_0010366
Disease	cerebellum cortex volume change measurement, age at assessment	SLC16A11 CSMD1	1.59e-03	26	67	2	EFO_0008007, EFO_0021497
Disease	periodontitis	FBXO38 MCM3AP WDR73 CSMD1	1.68e-03	223	67	4	EFO_0000649

Protein segments in the cluster

Peptide	Gene	Start	Entry
RLHFTSDSNHRRKGF	CSMD1	291	Q96PZ7
RREGSRFHHGDTLKF	CSMD2	531	Q7Z408
EELHFGEGVHRKAFR	ALPK2	1921	Q86TB3
DELRQFHHSRGSPFK	ARID2	21	Q68CP9
SHFLHRVQGFRRRGG	AHDC1	656	Q5TGY3
GDRLSHERHQFQRDK	RAB11FIP3	601	O75154
ERHICGRLFGEKFRH	LTA4H	326	P09960
GRHSERFDRNIASFH	ANKRD27	146	Q96NW4
RKHRRGGFSHRCFPT	SLC16A11	6	Q8NCK7
DAVRHARKHFSQAEG	MAEA	216	Q7L5Y9
DNDRRLADHFGGKLH	LUC7L	201	Q9NQ29
EGGELFHRISQHRHF	MAPKAPK5	106	Q8IW41
SDVRFQHFLLHREGK	KIR2DL3	51	P43628
DSEVRRAFGHFHQGR	MTMR11	241	A4FU01
GFGVHPKNIFRDRHA	KCNH7	281	Q9NS40
GHEFSGRFFHDRRER	MCM3AP	1581	O60318
RFLQKRFRHHLGDDV	GLB1	201	P16278
RSGDHRGKFKVASFR	PEBP1	141	P30086
FGHRFQLRVGHGDKN	MTMR2	456	Q13614
EAGHNRRHFKAASLE	GOLGA3	1201	Q08378
LRGFLVRQKFAEHSH	IQGAP3	741	Q86VI3
SHFRVLIHEFRDGRK	PCDHB16	176	Q9NRJ7
HVHILGKFRNRNGAF	FBXO38	161	Q6PIJ6
RLFHDGKHFVGEKRF	CHN2	106	P52757
FHFRRLQFNKHGVLR	KDM3A	571	Q9Y4C1
KQHVDARGERHGDIF	HEPHL1	756	Q6MZM0
HRRKFGERHIFDGNS	PIWIL3	166	Q7Z3Z3
ECRNFEHGFRVHGKN	MIER2	306	Q8N344
SHGFRKAIAERHGNL	OGT	516	O15294
DNDRRLADHFGGKLH	LUC7L2	201	Q9Y383
HFHVLTRNRSEGRKF	PCDHB6	176	Q9Y5E3
RDGARSKRHQKFTHF	FGF20	176	Q9NP95
DKGAKPERGRFLHFH	HPD	6	P32754
RLNFHRDPGFFSNKH	RTTN	266	Q86VV8
DHRRIGKEQELFFFH	TARS2	301	Q9BW92
TKRAFDFSAHGRRHV	PUS3	51	Q9BZE2
FKHRRARFLHETGLA	SLC9A6	91	Q92581
FKNHRFRFLHETGGA	SLC9A9	41	Q8IVB4
RDHLGHRKQYGGDFL	NXPE2	136	Q96DL1
GRAHPDSRRAVFHFH	PLCE1	176	Q9P212
RGRAHGEFQRKDFSE	HEXIM2	181	Q96MH2
HFRLFDVGGQRSERK	GNAO1	196	P09471
AGDERRALSFFHQKG	SEMA4A	46	Q9H3S1
QRKLEGCRFLHGYHR	OSM	186	P13725
NRQDRFHDFDHRDRG	SAFB	741	Q15424
DKLGRTAFHRAAEHG	ANKDD1A	156	Q495B1
DKAFGRDSHLAQHTR	ZNF845	781	Q96IR2
HHFQRLRGREGGSHF	TBL1X	26	O60907
KGFRHLGFFTRHQRT	ZNF707	351	Q96C28
LGFFTRHQRTHRHGE	ZNF707	356	Q96C28
RAFREKIDFQHAHGL	ZNF451	101	Q9Y4E5
GDHASGFRHNDVIRF	TEX13D	6	A0A0J9YY54
GKAFKRRFHLTEHQR	ZNF599	261	Q96NL3
LFNHKIHQGIARRFG	RGS12	346	O14924
QGRLSREHRGLFNHE	PRR19	66	A6NJB7
RLDGRNFHRFAEKHN	THG1L	56	Q9NWX6
TVGFHGSRKRSRDHF	TSSC4	301	Q9Y5U2
RGHRGKAVFLARDKH	RIMKLB	161	Q9ULI2
GKAFRGHSDFSRHQS	ZNF16	271	P17020
HLGEKHFRSNVGRAL	ZNF154	61	Q13106
GKDFRFHSQLTEHQR	ZNF529	316	Q6P280
FKHRRVRFLHETGLA	SLC9A7	91	Q96T83
SFGKNSERRERMGHH	ZRSR2	356	Q15696
AFGREHVERHFRKTG	USP13	71	Q92995
ERDFKVRHGGFSDRS	WDR73	71	Q6P4I2
HIRHRRNHFGERSFE	ZNF17	541	P17021
KIARHFRFGNQEDAH	USP36	196	Q9P275
FGKAFREDGSLRAHN	ZNF114	226	Q8NC26
GKFFRTDSQLNRHHR	ZNF527	476	Q8NB42
FEFEARGKLRHRHTH	VPS13D	2951	Q5THJ4