Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	neuron projection cytoplasm	AP3M2 DLG2 AP3M1 HTT	2.47e-04	110	58	4	GO:0120111
GeneOntologyCellularComponent	lysosomal membrane	ATP11B RRAGD VPS13A CP TSC2 AP3M1 GAA	2.80e-04	462	58	7	GO:0005765
GeneOntologyCellularComponent	lytic vacuole membrane	ATP11B RRAGD VPS13A CP TSC2 AP3M1 GAA	2.80e-04	462	58	7	GO:0098852
GeneOntologyCellularComponent	vacuolar membrane	ATP11B RRAGD VPS13A CP TSC2 AP3M1 GAA	4.89e-04	507	58	7	GO:0005774
GeneOntologyCellularComponent	AP-3 adaptor complex	AP3M2 AP3M1	5.79e-04	13	58	2	GO:0030123
GeneOntologyCellularComponent	axon cytoplasm	AP3M2 DLG2 AP3M1	8.94e-04	68	58	3	GO:1904115
Domain	Cu_oxidase_CS	CP F5	9.75e-05	5	59	2	IPR033138
Domain	Cu-oxidase_3	CP F5	9.75e-05	5	59	2	IPR011707
Domain	MULTICOPPER_OXIDASE1	CP F5	9.75e-05	5	59	2	PS00079
Domain	Cu-oxidase_3	CP F5	9.75e-05	5	59	2	PF07732
Domain	-	EMC1 ERN1	1.46e-04	6	59	2	2.140.10.10
Domain	Clathrin_mu_CS	AP3M2 AP3M1	1.46e-04	6	59	2	IPR018240
Domain	CLAT_ADAPTOR_M_1	AP3M2 AP3M1	1.46e-04	6	59	2	PS00990
Domain	CLAT_ADAPTOR_M_2	AP3M2 AP3M1	1.46e-04	6	59	2	PS00991
Domain	Quinoprotein_ADH-like_fam	EMC1 ERN1	1.46e-04	6	59	2	IPR027295
Domain	PQQ_repeat	EMC1 ERN1	1.46e-04	6	59	2	IPR002372
Domain	Cu_oxidase_Cu_BS	CP F5	1.46e-04	6	59	2	IPR002355
Domain	Clathrin_mu	AP3M2 AP3M1	4.34e-04	10	59	2	IPR001392
Domain	Adap_comp_sub	AP3M2 AP3M1	5.30e-04	11	59	2	PF00928
Domain	Clathrin_sm-chain_CS	AP3M2 AP3M1	6.34e-04	12	59	2	IPR000804
Domain	MHD	AP3M2 AP3M1	7.48e-04	13	59	2	PS51072
Domain	MHD	AP3M2 AP3M1	7.48e-04	13	59	2	IPR028565
Domain	-	CP F5	8.71e-04	14	59	2	2.60.40.420
Domain	AP_mu_sigma_su	AP3M2 AP3M1	1.14e-03	16	59	2	IPR022775
Domain	Clat_adaptor_s	AP3M2 AP3M1	1.14e-03	16	59	2	PF01217
Domain	ARM-like	TSC2 ARMC9 MEI1 AGBL1 HTT	1.61e-03	270	59	5	IPR011989
Domain	Cupredoxin	CP F5	2.18e-03	22	59	2	IPR008972
Domain	Longin-like_dom	AP3M2 AP3M1	3.52e-03	28	59	2	IPR011012
Domain	ARM-type_fold	TSC2 ARMC9 MEI1 AGBL1 HTT	4.30e-03	339	59	5	IPR016024
Pubmed	Sphingosine-1-phosphate receptor S1P1 is regulated by direct interactions with P-Rex1, a Rac guanine nucleotide exchange factor.	PREX1 S1PR1	2.83e-06	2	59	2	20036214
Pubmed	IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux.	ERN1 HTT	2.83e-06	2	59	2	21954231
Pubmed	Positional cloning and characterization of Mei1, a vertebrate-specific gene required for normal meiotic chromosome synapsis in mice.	MEI1 XRCC6	1.69e-05	4	59	2	14668445
Pubmed	Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1α.	ERN1 HTT	1.69e-05	4	59	2	24951540
Pubmed	p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.	TSC2 SESN1	2.82e-05	5	59	2	18692468
Pubmed	Association analysis between schizophrenia and the AP-3 complex genes.	AP3M2 AP3M1	2.82e-05	5	59	2	19481122
Pubmed	The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.	SKI HTT	2.82e-05	5	59	2	10823891
Pubmed	Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.	RRAGD TSC2	4.23e-05	6	59	2	24529380
Pubmed	Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.	RRAGD SESN1	5.91e-05	7	59	2	25259925
Pubmed	Characterization of the adaptor-related protein complex, AP-3.	AP3M2 AP3M1	5.91e-05	7	59	2	9151686
Pubmed	Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.	TSC2 SESN1	7.87e-05	8	59	2	23274085
Pubmed	Association of the AP-3 adaptor complex with clathrin.	AP3M2 AP3M1	7.87e-05	8	59	2	9545220
Pubmed	Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator.	MED23 XRCC6	7.87e-05	8	59	2	10823961
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KIAA0930 FAT1 MDN1 LPAR5 RASA3 TSC2 PREX1 FOXK1 HTT	9.63e-05	1105	59	9	35748872
Pubmed	HIV-1 Vpu inhibits accumulation of the envelope glycoprotein within clathrin-coated, Gag-containing endosomes.	AP3M2 AP3M1	1.26e-04	10	59	2	18076669
Pubmed	A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation.	DIS3L2 DLG2	1.54e-04	11	59	2	19570815
Pubmed	High-resolution mapping of mouse chromosome 8 identifies an evolutionary chromosomal breakpoint.	FAT1 TLL1	1.85e-04	12	59	2	9680377
Pubmed	The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.	TSC2 SESN1	1.85e-04	12	59	2	25263562
Pubmed	Expression patterns of the lysophospholipid receptor genes during mouse early development.	LPAR5 S1PR1	2.18e-04	13	59	2	18924241
Pubmed	Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling.	DNAJC6 IFNAR2	2.54e-04	14	59	2	32123171
Pubmed	TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer.	RRAGD TSC2	2.54e-04	14	59	2	28716898
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	DIS3L2 AP3M2 SKI GAA	2.69e-04	183	59	4	31932471
Pubmed	Lysophospholipid receptor nomenclature review: IUPHAR Review 8.	LPAR5 S1PR1	2.93e-04	15	59	2	24602016
Pubmed	Cell type-specific Rab32 and Rab38 cooperate with the ubiquitous lysosome biogenesis machinery to synthesize specialized lysosome-related organelles.	AP3M2 AP3M1	3.34e-04	16	59	2	23247405
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	FAT1 ATP11B ERN1 VPS13A AP3M1 ZNF44	3.44e-04	552	59	6	10737800
Pubmed	Docking motif-guided mapping of the interactome of protein phosphatase-1.	ORC5 DLG2 TSC2	3.47e-04	80	59	3	19389623
Pubmed	Hereditary Dystonia Overview	VPS13A CP HTT	3.73e-04	82	59	3	20301334
Pubmed	The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse.	AP3M2 AP3M1	4.25e-04	18	59	2	21998198
Pubmed	Effect of expression alteration in flanking genes on phenotypes of St8sia2-deficient mice.	LRRC28 AGBL1	4.25e-04	18	59	2	31541165
Pubmed	Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.	NAALAD2 CDK6	5.27e-04	20	59	2	21738478
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	ORC5 EMC1 MDN1 VPS13A TSC2 XRCC6	5.62e-04	606	59	6	36538041
Pubmed	The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.	ERN1 RASA3 PREX1 S1PR1	6.07e-04	227	59	4	26410627
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KIAA0930 EMC1 MDN1 USP22 TSC2 PPIP5K2 FOXK1	6.20e-04	861	59	7	36931259
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	KIAA0930 ATP11B VPS13A	7.07e-04	102	59	3	10231032
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	MDN1 TSC2 HTT	7.48e-04	104	59	3	31240132
Pubmed	Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation.	TLL1 CDK6	7.62e-04	24	59	2	26744331
Pubmed	Human immunodeficiency virus type-1 gag and host vesicular trafficking pathways.	AP3M2 AP3M1	7.62e-04	24	59	2	20012524
Pubmed	Defects in the cappuccino (cno) gene on mouse chromosome 5 and human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent mechanism.	AP3M2 AP3M1	8.28e-04	25	59	2	11110696
Pubmed	Self-assembling protein microarrays.	ORC5 CDK6	1.19e-03	30	59	2	15232106
Pubmed	Integral and associated lysosomal membrane proteins.	CP AP3M1 GAA	1.30e-03	126	59	3	17897319
Pubmed	Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.	F5 AGBL1	1.44e-03	33	59	2	22703881
Pubmed	Discovery and validation of genes driving drug-intake and related behavioral traits in mice.	FAR2 CP	1.44e-03	33	59	2	38164795
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	MDN1 USP22 LPAR5 VPS13A TSC2 XRCC6	1.53e-03	736	59	6	29676528
Pubmed	Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.	CP CDK6	1.53e-03	34	59	2	15221005
Pubmed	miR-195b is required for proper cellular homeostasis in the elderly.	ERN1 CDK6	1.53e-03	34	59	2	38191655
Interaction	AP3B2 interactions	AP3M2 AP3M1 PREX1 HTT	9.02e-06	45	59	4	int:AP3B2
Interaction	C3orf18 interactions	ORC5 MDN1 USP22 FAR2 TSC2	2.17e-05	115	59	5	int:C3orf18
Cytoband	7q22.1	ORC5 SPDYE3 KMT2E	4.27e-04	113	59	3	7q22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr22q13	KIAA0930 DENND6B MEI1 XRCC6	8.74e-04	330	59	4	chr22q13
Cytoband	Ensembl 112 genes in cytogenetic band chr6q15	MDN1 RRAGD	1.99e-03	51	59	2	chr6q15
Cytoband	22q13.2	MEI1 XRCC6	2.74e-03	60	59	2	22q13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr7q22	ORC5 SPDYE3 KMT2E	2.86e-03	219	59	3	chr7q22
Cytoband	2q37.1	DIS3L2 ARMC9	3.40e-03	67	59	2	2q37.1
Coexpression	GSE40655_FOXO1_KO_VS_WT_NTREG_UP	EMC1 RASA3 DENND6B KMT2E PREX1 FOXK1	5.33e-06	200	58	6	M9439
Coexpression	GSE35825_UNTREATED_VS_IFNA_STIM_MACROPHAGE_UP	ORC5 RASA3 ACSS1 PREX1 SESN1	4.08e-05	173	58	5	M8658
Coexpression	GSE6092_IFNG_VS_IFNG_AND_B_BURGDORFERI_INF_ENDOTHELIAL_CELL_UP	LPAR5 ACSS1 SKI SESN1 S1PR1	4.93e-05	180	58	5	M6718
Coexpression	GSE20152_SPHK1_KO_VS_HTNFA_OVEREXPRESS_ANKLE_DN	ORC5 FBXW4 DCLRE1A SESN1 XRCC6	7.56e-05	197	58	5	M7683
Coexpression	GSE17580_TREG_VS_TEFF_UP	MDN1 RRAGD GUCY1A1 SESN1 CDK6	8.12e-05	200	58	5	M3670
Coexpression	GSE40068_CXCR5POS_BCL6POS_TFH_VS_CXCR5NEG_BCL6NEG_CD4_TCELL_UP	KIAA0930 ACSS1 KMT2E SKI S1PR1	8.12e-05	200	58	5	M9258
Coexpression	GSE7852_LN_VS_FAT_TCONV_UP	EMC1 ATP11B SESN1 GAA HTT	8.12e-05	200	58	5	M5747
Coexpression	GSE19825_IL2RALOW_VS_IL2RAHIGH_DAY3_EFF_CD8_TCELL_DN	MDN1 ERN1 DNAJC6 FOXK1 CDK6	8.12e-05	200	58	5	M4302
CoexpressionAtlas	dev gonad_e12.5_F_VasAssMesen_MafB_k-means-cluster#4_top-relative-expression-ranked_1000	ERN1 RASA3 PPIP5K2 PEX11A SESN1 CDK6 IFNAR2	1.74e-05	301	58	7	gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_k4_1000
ToppCell	Mesenchymal_cells-Osteo-CAR\|Mesenchymal_cells / Lineage and Cell class	FAT1 CP ST6GALNAC4 S1PR1 IFNAR2	3.45e-06	174	59	5	430e3cd61bc2a471959faa40e817aa4dd7d82d28
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RRAGD ERN1 ST6GALNAC4 MEI1 IFNAR2	4.42e-06	183	59	5	c5e90577b57a86c06afdf89d4b519b3694f813f9
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-Plasma_cells\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RRAGD ERN1 ST6GALNAC4 MEI1 IFNAR2	4.66e-06	185	59	5	a4792d8df52d80951fb9d022c49821df52100e67
ToppCell	droplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l14\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ORC5 DCLRE1A MED23 F5	1.71e-05	116	59	4	f2bf9599040f43b5ea8724841d7b71c0a859c016
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-Tfh\|Liver / Manually curated celltypes from each tissue	ORC5 PEX11A DNAJC6 BBS10	5.46e-05	156	59	4	85bc34ff507f9a66c6e3ba7a3ffd5416d0073ccf
ToppCell	wk_20-22-Hematologic-Myeloid-CMP\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	BCL2L14 FAR2 RRAGD CDK6	7.27e-05	168	59	4	e223bd7ae2a28c007e8b365f30d50d3bee83ba38
ToppCell	facs-Lung-24m-Mesenchymal-myofibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FAT1 NAALAD2 GUCY1A1 ZNF575	8.33e-05	174	59	4	a7ade7372e83edd4e3983e77f8417b51f0b47340
ToppCell	droplet-Lung-nan-18m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ORC5 BCL2L14 DCLRE1A EXTL1	8.71e-05	176	59	4	24b2e94ee5defcefb64a1f2447a2cc71b015b0fd
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D122\|Adult / Lineage, Cell type, age group and donor	FAT1 CYP4X1 CP AGBL1	8.71e-05	176	59	4	3fee8a367bb9755aca1b7fcc968b08e51b6e9436
ToppCell	droplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ORC5 BCL2L14 DCLRE1A EXTL1	8.90e-05	177	59	4	f360f7099570d248531897b96e0de282e58f59e9
ToppCell	nucseq-Epithelial-Epithelial_Airway-Secretory/RAS\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TLL1 CYP4X1 CP B4GALNT3	8.90e-05	177	59	4	779ba86f53650772755b52460be03f18bb204e55
ToppCell	nucseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TLL1 CYP4X1 CP B4GALNT3	8.90e-05	177	59	4	0f210cfb61b873c5fd77dc17eadf4d017306500e
ToppCell	TCGA-Head_and_Esophagus-Solid_Tissue_Normal-Head_and_Neck-Head_and_Neck_normal_tissue\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	RRAGD DLG2 EXTL1 AGBL1	8.90e-05	177	59	4	675003fbecee1b86919d1a6eeb268e1ca298f714
ToppCell	TCGA-Head_and_Esophagus-Solid_Tissue_Normal-Head_and_Neck\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	RRAGD DLG2 EXTL1 AGBL1	8.90e-05	177	59	4	72d144289167f200ac9f006d130de31e45568484
ToppCell	facs-Spleen-nan-3m-Lymphocytic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASA3 ACSS1 SESN1 S1PR1	9.50e-05	180	59	4	87fb1fdbc49c808bb5f6fe9fb747057b45fa78d0
ToppCell	Control-Epithelial-Goblet\|Control / Disease state, Lineage and Cell class	TLL1 CYP4X1 CP B4GALNT3	9.50e-05	180	59	4	5293d23b8b8ea587239ffde561b70bad01632521
ToppCell	facs-Spleen-nan-3m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASA3 ACSS1 SESN1 S1PR1	9.50e-05	180	59	4	c0c3144011856d005aebd5cdc79f89fee32083a8
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_3\|368C / Donor, Lineage, Cell class and subclass (all cells)	ORC5 MED23 F5 CDK6	9.70e-05	181	59	4	b193f3606554adc55c5906219d114288bb1f978a
ToppCell	Mesenchymal_cells-Adipo-CAR\|Mesenchymal_cells / Lineage and Cell class	RASA3 CP S1PR1 IFNAR2	9.70e-05	181	59	4	1cfb03eb03a37b036b4eeacec69c9b8163af1ee4
ToppCell	Epithelial-lung_goblet_cell\|World / Lineage, Cell type, age group and donor	TLL1 CYP4X1 CP B4GALNT3	1.01e-04	183	59	4	940cbe298e9c53b5622af09264586ed823d3141f
ToppCell	COVID-CD4-naive_CD4\|COVID / Condition, Cell_class and T cell subcluster	BCL2L14 AP3M2 F5 S1PR1	1.03e-04	184	59	4	00db55970d336a301035efe43a4ab4db62627f38
ToppCell	facs-Lung-24m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FAT1 NAALAD2 GUCY1A1 ZNF575	1.06e-04	185	59	4	a6cd90f8f30c7bdf66958cf403e73c193aa32f5e
ToppCell	Control-Epithelial-Goblet\|World / Disease state, Lineage and Cell class	TLL1 CYP4X1 CP B4GALNT3	1.06e-04	185	59	4	9a793e6016295a63820e9d7563f195494ac692e7
ToppCell	facs-Lung-24m-Mesenchymal-myofibroblast-pericyte_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FAT1 NAALAD2 GUCY1A1 ZNF575	1.06e-04	185	59	4	5053f932e2adfcf4d6faaecff2999ac53d8d7aa5
ToppCell	Adult-Epithelial-club_cell-D231\|Adult / Lineage, Cell type, age group and donor	FAT1 TLL1 CP B4GALNT3	1.10e-04	187	59	4	ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_3\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ORC5 MED23 F5 CDK6	1.10e-04	187	59	4	689b3cc76f1e04bd35a7d3ce19e9f08744a7835b
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ORC5 MED23 F5 CDK6	1.10e-04	187	59	4	4527d6426f2c4397e47f12439a13a8c14fd2aab2
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-plasmacytoid_dendritic_cell-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ERN1 DCLRE1A ST6GALNAC4 BBS10	1.10e-04	187	59	4	d3563bb087e476baea5b59389e4d34d0ff98cac5
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERN1 ST6GALNAC4 MEI1 IFNAR2	1.12e-04	188	59	4	fd4d304f1cb41e694d21b5441739eb34a5a13b04
ToppCell	Adult-Epithelial-club_cell\|Adult / Lineage, Cell type, age group and donor	FAT1 TLL1 CP B4GALNT3	1.17e-04	190	59	4	756bff697d30aec56c0ebfca94295f084a15bf37
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	PIGN AP3M2 PREX1 S1PR1	1.17e-04	190	59	4	91ba66d4b56c59523485b17738e93f14bb00afa4
ToppCell	metastatic_Lymph_Node-B_lymphocytes-MALT_B_cells\|B_lymphocytes / Location, Cell class and cell subclass	ERN1 ST6GALNAC4 MEI1 IFNAR2	1.17e-04	190	59	4	5ec49cc7692053c1a525ca9137c996ccd2794e1c
ToppCell	(1)_Osterolineage_cells-(10)_OLC-1\|(1)_Osterolineage_cells / Cell class and subclass of bone marrow stroma cells in homeostatis	FAT1 GUCY1A1 CP S1PR1	1.19e-04	191	59	4	78ad7c555409ce1391bce406bc0f3ef575329ece
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ERN1 VPS13A AP3M2 S1PR1	1.19e-04	191	59	4	4a29b7d5cd10e9077699d3aa76e3db6c4d5a0cf6
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0930 ACSS1 AGBL1 S1PR1	1.22e-04	192	59	4	2de242d81dc085ae734eb7d1f091af9a542e0866
ToppCell	10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-ELP\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	GUCY1A1 DENND6B LRRC28 CDK6	1.22e-04	192	59	4	38ec82aa2ec4f2c0a843e83f7fe54f6b2483ca3d
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0930 ACSS1 AGBL1 S1PR1	1.22e-04	192	59	4	ba2a683472a8b785dbf666dc6e94356d879486c3
ToppCell	343B-Lymphocytic-ILC-ILC-1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	USP22 ATP11B LRRC28 HTT	1.22e-04	192	59	4	445985fe1bcd33e4f0a1704b27988fbfc9334538
ToppCell	Epithelial-club_cell\|World / Lineage, Cell type, age group and donor	FAT1 TLL1 CP B4GALNT3	1.24e-04	193	59	4	2bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCell	severe-Myeloid-Neutrophils_3\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	ATP11B SKI F5 PREX1	1.24e-04	193	59	4	f4d43dfbf4115dd0f843ea5cf08049220342a047
ToppCell	Severe-Plasmablast\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	ERN1 ST6GALNAC4 MEI1 IFNAR2	1.32e-04	196	59	4	ee991f1d9936c656f4fbc2e0cec9e0166a34bc5b
ToppCell	tumor_Lung-B_lymphocytes-MALT_B_cells\|B_lymphocytes / Location, Cell class and cell subclass	ERN1 ST6GALNAC4 MEI1 IFNAR2	1.32e-04	196	59	4	1f63dba9d226e4a42d9bee7258580a1e547c0e92
ToppCell	(2)_B_cells-(2)_Plasma_cells\|(2)_B_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	ERN1 ST6GALNAC4 MEI1 IFNAR2	1.32e-04	196	59	4	cc4f59b885d58e43471e85c51d8e366e68d10846
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-Teffector/EM_CD4\|lymph-node_spleen / Manually curated celltypes from each tissue	ERN1 RASA3 AP3M2 S1PR1	1.34e-04	197	59	4	c4603bfe9ab537ca64172f65203a5d23671f7354
ToppCell	facs-Heart\|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAALAD2 GUCY1A1 CP S1PR1	1.34e-04	197	59	4	6a9571c0a3238b39214afdece93d7541bc8a0a70
ToppCell	Severe-Plasmablast\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	ERN1 ST6GALNAC4 MEI1 IFNAR2	1.34e-04	197	59	4	1089aa7991812378668d0f3d57f8000e6245a713
ToppCell	B_cells-Plasmablasts\|B_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	ERN1 ST6GALNAC4 MEI1 IFNAR2	1.37e-04	198	59	4	c6cab47885be74a64351f843a741dea6d911bde4
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	BCL2L14 FAT1 ERN1 CP	1.37e-04	198	59	4	285f729140b1df029c24f6ca1d2438470ac51794
ToppCell	Caecum-(1)_T_cell-(14)_Tcm\|Caecum / shred on region, Cell_type, and subtype	RASA3 AP3M2 F5 S1PR1	1.40e-04	199	59	4	0f89426e8dec0cbe78f6c55caaa196daf0eaf66a
ToppCell	Caecum-T_cell-Tcm\|Caecum / Region, Cell class and subclass	RASA3 AP3M2 F5 S1PR1	1.40e-04	199	59	4	cab97db995a7d7df3b8f0511139ef0fe65ee55b9
ToppCell	Transverse-T_cell-Activated_CD4_T\|T_cell / Region, Cell class and subclass	CLYBL RASA3 AP3M2 S1PR1	1.42e-04	200	59	4	d89d3c16406d77cb08e1aa00d7df6887a692c337
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-T/NK-MAIT\|Leuk-UTI / Disease, condition lineage and cell class	ORC5 ERN1 SPDYE3 PEX11A	1.42e-04	200	59	4	7e0d0f051c197c2c70080f039e1c4dd68db8e74f
Disease	triiodothyronine measurement	DLG2 AGBL1	4.48e-04	16	58	2	EFO_0008392
Disease	advanced glycosylation end product-specific receptor ligand measurement	OR14J1 B4GALNT3	7.78e-04	21	58	2	EFO_0010762
Disease	partial thromboplastin time	F5 AGBL1	1.02e-03	24	58	2	EFO_0004310
Disease	Brain Diseases	CP TSC2	1.11e-03	25	58	2	C0006111
Disease	uric acid measurement	PIGN NAALAD2 RRAGD SKI F5 FOXK1	1.24e-03	610	58	6	EFO_0004761
Disease	Encephalopathies	CP TSC2	1.29e-03	27	58	2	C0085584
Disease	Glioblastoma Multiforme	FAT1 ERN1 CDK6	1.38e-03	111	58	3	C1621958
Disease	smoking behavior, BMI-adjusted waist circumference	DIS3L2 PREX1 CDK6	1.80e-03	122	58	3	EFO_0004318, EFO_0007789

Protein segments in the cluster

Peptide	Gene	Start	Entry
YLLYAALTHKLVFDH	ACSS1	311	Q9NUB1
ISKPVSLSASHRYYF	B4GALNT3	231	Q6L9W6
SLSASHRYYFEVLHK	B4GALNT3	236	Q6L9W6
ILAYYTRHHVFKSTP	BCL2L14	26	Q9BZR8
AKRISAYSALSHPYF	CDK6	286	Q00534
TPHHYLISIYRDKLF	AP3M1	51	Q9Y2T2
LYTAYTAHLHRDKAL	DENND6B	381	Q8NEG7
FRHYALNVPLYTHFT	DIS3L2	686	Q8IYB7
KYSFPHTYIRAVHAL	BBS10	651	Q8TAM1
TIYHAKGLLYHLSSI	AGBL1	876	Q96MI9
SSSHHKYIPRRAVLY	CLYBL	36	Q8N0X4
KRLTVYHPSAYLSGH	RASA3	681	Q14644
YVHLKNLASRPYTFH	CP	106	P00450
TPHHYLLSVYRHKIF	AP3M2	51	P53677
AIPAYSHLRYVFKST	FAT1	391	Q14517
YTAVHRPKSTLVYHI	FAR2	291	Q96K12
PHEAKHYLSLFLSCY	MDN1	3646	Q9NU22
FTLSLPVRLSYYALH	LPAR5	71	Q9H1C0
HIHFAIYLLKYSVGR	ARMC9	101	Q7Z3E5
YAHLTYVTLPLHRIL	KIAA0930	376	Q6ICG6
RRLHSPMYYFLKHLS	OR14J1	51	Q9UGF5
KFHDRPVTYLYNTLH	MED23	996	Q9ULK4
IHLYIYSIHSIPKGT	KMT2E	426	Q8IZD2
PHVYSTPKHYIRFTS	KMT2E	781	Q8IZD2
LKNHSIVPTHYTLLY	IFNAR2	56	P48551
YTHHPLLLRFFLLYP	MEI1	776	Q5TIA1
SLGSFYHLPSYLKLH	HTT	1226	P42858
CYFTSRFPHLLAHTY	ERN1	931	O75460
KIIFHRLYSLLYHSD	CYP4X1	221	Q8N118
RHLDHYTVYNLSPKS	DNAJC6	101	O75061
LTLSGIYAHITKHYP	FOXK1	326	P85037
LRYALLPHLYTLFHQ	GAA	701	P10253
LTTKHLYAALSYNLH	FBXW4	391	P57775
KSFLLSAPYSHYHLG	DLG2	371	Q15700
FFLHLSPSHYALLQY	EMC1	291	Q8N766
PFHYKRYTHFLLAQS	DCLRE1A	166	Q6PJP8
KIHLSFYLTSIYDHS	RRAGD	211	Q9NQL2
CSTVLPLYHKHYILF	S1PR1	191	P21453
PLYHKHYILFCTTVF	S1PR1	196	P21453
HPQYLESFLKTQHYL	SESN1	91	Q9Y6P5
FHIRYKSIRYPDTTH	TLL1	996	O43897
RPYSLHAHGLSYEKS	F5	1666	P12259
LYHTYHSLLKDLNFL	LRRC28	281	Q86X40
AHTHVELPYYSKFIL	ORC5	296	O43913
FYLDSYHFSKLPSRL	PREX1	1441	Q8TCU6
TRAAHHYYYSLLLSL	PEX11A	121	O75192
YYHTLFTHSLPKALR	EXTL1	561	Q92935
HLPALIRDSFYSYKS	SKI	396	P12755
SKLLFVHGHFYYIRI	ATP11B	861	Q9Y2G3
LKKHHYLRPSLFVYP	XRCC6	356	P12956
HTSVPLLLRNYSHYF	ST6GALNAC4	126	Q9H4F1
FYSGHRSPHIPYKLL	USP22	231	Q9UPT9
YEYFHISPIKLHLSV	VPS13A	2766	Q96RL7
IFYFLYGKTHSHIPL	SPDYE3	466	A6NKU9
AFSYPSKLATHRLAH	ZNF575	71	Q86XF7
HLALKGLSYYHTYDR	PIGN	426	O95427
FYQFSYLTRHKLIHT	ZNF493	146	Q6ZR52
RLHSTYRHDLKIYAS	PPIP5K2	551	O43314
AFPVYSSYLRHEKIH	ZNF44	281	P15621
LHYKHSYTLPIASSI	TSC2	596	P49815
HVYYFFPKRTTSLIL	GUCY1A1	201	Q02108
FYRHIIFAPSSHNKY	NAALAD2	676	Q9Y3Q0