Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	fn3	CHL1 MYLK PTPRM INSR ROS1 FLRT3 IL23R	9.08e-06	162	85	7	PF00041
Domain	FN3	CHL1 MYLK PTPRM INSR ROS1 FLRT3 IL23R	2.15e-05	185	85	7	SM00060
Domain	FN3	CHL1 MYLK PTPRM INSR ROS1 FLRT3 IL23R	3.43e-05	199	85	7	PS50853
Domain	FN3_dom	CHL1 MYLK PTPRM INSR ROS1 FLRT3 IL23R	4.69e-05	209	85	7	IPR003961
Domain	P-loop_NTPase	DLG5 DDX17 DNAH12 UTP25 SULT1C2 ATAD2B ASPM MFN2 AK6 CHD6 HS3ST1 DDX5 RAD50	1.14e-04	848	85	13	IPR027417
Domain	-	DLG5 DDX17 DNAH12 UTP25 SULT1C2 ATAD2B MFN2 AK6 CHD6 HS3ST1 DDX5 RAD50	1.37e-04	746	85	12	3.40.50.300
Domain	SH3_domain	EPS8 DLG5 SHANK2 NEBL MACF1 ZNF582	5.03e-04	220	85	6	IPR001452
Domain	Tyr_kinase_rcpt_2_CS	INSR ROS1	1.10e-03	11	85	2	IPR002011
Domain	RECEPTOR_TYR_KIN_II	INSR ROS1	1.31e-03	12	85	2	PS00239
Domain	SH3	EPS8 DLG5 SHANK2 NEBL MACF1	3.06e-03	216	85	5	PS50002
Domain	CH	FLNB ASPM MACF1	3.24e-03	65	85	3	SM00033
Domain	CH	FLNB ASPM MACF1	4.00e-03	70	85	3	PF00307
Domain	-	FLNB ASPM MACF1	4.16e-03	71	85	3	1.10.418.10
Domain	CH	FLNB ASPM MACF1	4.50e-03	73	85	3	PS50021
Domain	Ig-like_fold	CHL1 FLNB SHANK2 MYLK PTPRM INSR ROS1 FLRT3 IL23R	4.76e-03	706	85	9	IPR013783
Domain	CH-domain	FLNB ASPM MACF1	4.85e-03	75	85	3	IPR001715
Domain	Actinin_actin-bd_CS	FLNB MACF1	4.87e-03	23	85	2	IPR001589
Domain	ACTININ_2	FLNB MACF1	4.87e-03	23	85	2	PS00020
Domain	ACTININ_1	FLNB MACF1	4.87e-03	23	85	2	PS00019
Domain	ARM-like	SF3B1 ASPM DOCK10 PSMD2 ARID1A	7.80e-03	270	85	5	IPR011989
Domain	DEAD_ATP_HELICASE	DDX17 DDX5	8.74e-03	31	85	2	PS00039
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	YEATS2 SIRT2 DDX17 SF3B1 CHERP ALMS1 NEBL NUFIP2 MACF1 DIDO1 TFCP2 DDX5 DNMT1 RAD50	8.09e-08	934	87	14	33916271
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	FLNB SF3B1 CHERP UTP25 ATAD2B NUFIP2 MACF1 DIDO1 PSMD2 ARID1A DNMT1 RAD50	8.54e-08	653	87	12	22586326
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	FLNB PTPA DDX17 SF3B1 CHERP MRPL22 NEMF NUFIP2 MFN2 MACF1 DIDO1 PSMD2 TOP3B NENF DDX5 DNMT1	1.25e-07	1297	87	16	33545068
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	DDX17 SF3B1 CHERP VPS13C NUFIP2 DIDO1 PSMD2 ROS1 CHD6 DDX5 MOB2 RAD50	3.97e-07	754	87	12	35906200
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	SHANK2 PTPRM CSNK1G3 VPS13C DOCK10 MACF1	8.74e-07	128	87	6	30995482
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	ALMS1 RALGAPB DOCK10 MACF1 CHD6 ADGRV1 MED13L	1.63e-06	225	87	7	12168954
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	FLNB DDX17 SF3B1 ASPM MACF1 DDX5 RAD50	2.11e-06	234	87	7	36243803
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	YEATS2 EPS8 DLG5 SIRT2 ALMS1 ASPM MACF1 ARID1A DDX5 RAD50	2.20e-06	588	87	10	38580884
Pubmed	Identification of intracellular proteins associated with the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-ICR mass spectrometry.	DDX17 SF3B1 PSMD2 DNAJB5 DDX5 RAD50	2.29e-06	151	87	6	18457437
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	DDX17 SF3B1 CHERP ARID1A WIPF2 DDX5	2.57e-06	154	87	6	16055720
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	YEATS2 REXO2 DLG5 ZFP91 ASPM MACF1 DIDO1 ARID1A RAD50	2.91e-06	472	87	9	38943005
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	PITPNM2 EPS8 NEMF NUFIP2 KANK4 CHD6 TOP3B DDX5 DNMT1	3.06e-06	475	87	9	31040226
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	PCGF6 DLG5 KIFBP SF3B1 MRPL22 RALGAPB PEX19 MRPL27 ASPM MACF1 DNAJB5 TOP3B TFCP2 NENF DNMT1	3.95e-06	1487	87	15	33957083
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PITPNM2 YEATS2 FLNB SHANK2 VPS13C TBCK NEMF INSR RALGAPB MACF1 CHD6 ADGRV1 ARID1A ADCY1 FRMD3	4.01e-06	1489	87	15	28611215
Pubmed	Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.	DDX17 SF3B1 VPS13C DDX5	4.18e-06	43	87	4	26030138
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	YEATS2 EPS8 FLNB DDX17 SF3B1 CHERP ASPM ARID1A WIPF2	5.11e-06	506	87	9	30890647
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	FLNB DDX17 SF3B1 CHERP MRPL22 NUFIP2 MRPL27 MACF1 DIDO1 TOP3B DDX5	5.53e-06	807	87	11	22681889
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	EPS8 FLNB DDX17 SF3B1 UTP25 CSNK1G3 NUFIP2 MACF1 TFCP2 DDX5	6.09e-06	660	87	10	32780723
Pubmed	The Ddx5 and Ddx17 RNA helicases are cornerstones in the complex regulatory array of steroid hormone-signaling pathways.	DDX17 DDX5	6.19e-06	2	87	2	24275493
Pubmed	Helicases DDX5 and DDX17 promote heterogeneity in HBV transcription termination in infected human hepatocytes.	DDX17 DDX5	6.19e-06	2	87	2	38782119
Pubmed	Involvement of RNA helicases p68 and p72 in colon cancer.	DDX17 DDX5	6.19e-06	2	87	2	17699760
Pubmed	Identification of novel pathway partners of p68 and p72 RNA helicases through Oncomine meta-analysis.	DDX17 DDX5	6.19e-06	2	87	2	18005418
Pubmed	The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells.	DDX17 DDX5	6.19e-06	2	87	2	12595555
Pubmed	Upregulation of DEAD box helicase 5 and 17 are correlated with the progression and poor prognosis in gliomas.	DDX17 DDX5	6.19e-06	2	87	2	32008867
Pubmed	The roles of DEAD box helicases in the life cycle of HIV-1.	DDX17 DDX5	6.19e-06	2	87	2	26312911
Pubmed	DDX56 cooperates with FMDV 3A to enhance FMDV replication by inhibiting the phosphorylation of IRF3.	IRF3 DDX5	6.19e-06	2	87	2	31445188
Pubmed	Chromatin remodeler ARID1A binds IRF3 to selectively induce antiviral interferon production in macrophages.	IRF3 ARID1A	6.19e-06	2	87	2	34315861
Pubmed	Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression.	TFCP2 DNMT1	6.19e-06	2	87	2	27845898
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	YEATS2 KIFBP ATAD2B RALGAPB MACF1	6.29e-06	103	87	5	10574462
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FLNB PCGF6 DDX17 SF3B1 MRPL22 ACO2 ASPM DOCK10 MACF1 PSMD2 ARID1A DDX5 DNMT1 RAD50	6.47e-06	1353	87	14	29467282
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	FLNB DDX17 SF3B1 CHERP UTP25 NUFIP2 DIDO1 PSMD2 NENF DDX5 DNMT1 RAD50	6.54e-06	989	87	12	36424410
Pubmed	Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.	DDX17 SF3B1 NEMF MRPL27 ARID1A DDX5 DNMT1	7.35e-06	283	87	7	28533407
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	YEATS2 RALGAPB NUFIP2 DOCK10 MFN2 MACF1 CHD6 MED13L	8.57e-06	407	87	8	12693553
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	FLNB DDX17 SF3B1 CHERP MRPL22 PARP3 MACF1 ARID1A DDX5 DNMT1 RAD50	8.71e-06	847	87	11	35235311
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	FLNB KIFBP DDX17 SF3B1 CHERP VPS13C ACO2 KIAA0586 NEMF PSMD2 TFCP2 DDX5 DNMT1 RAD50	1.16e-05	1425	87	14	30948266
Pubmed	Human transcription factor protein interaction networks.	YEATS2 PCGF6 ALMS1 MRPL22 ACO2 ZFP91 DIDO1 PSMD2 IRF3 CHD6 ARID1A CNOT2 TFCP2 RAD50	1.20e-05	1429	87	14	35140242
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	PITPNM2 EPS8 FLNB SIRT2 DDX17 SF3B1 SHANK2 ACO2 NUFIP2 STON2 MACF1 PSMD2 ARID1A DDX5	1.22e-05	1431	87	14	37142655
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	FLNB SCN11A DDX17 SF3B1 SHANK2 MYLK ACO2 ASPM MACF1 PSMD2 CHD6 ARID1A TOP3B DDX5	1.33e-05	1442	87	14	35575683
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	DLG5 DDX17 SF3B1 NEBL ACO2 NEMF INSR NUFIP2 PSMD2 MED13L ARID1A CNOT2 DDX5	1.33e-05	1247	87	13	27684187
Pubmed	A "double adaptor" method for improved shotgun library construction.	SIRT2 DDX17 SF3B1 SHANK2 ATAD2B WIPF2 TOP3B ARHGAP19 AZIN1	1.40e-05	574	87	9	8619474
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	YEATS2 CHERP ALMS1 NEBL VPS13C NUFIP2 PEX19 CHD6 CNOT2 DNMT1	1.51e-05	733	87	10	34672954
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	KIFBP DDX17 SF3B1 CHERP MACF1 PSMD2 ARID1A DDX5 RAD50	1.56e-05	582	87	9	20467437
Pubmed	Aberrant MFN2 transcription facilitates homocysteine-induced VSMCs proliferation via the increased binding of c-Myc to DNMT1 in atherosclerosis.	MFN2 DNMT1	1.85e-05	3	87	2	31104361
Pubmed	Dock10 regulates CD23 expression and sustains B-cell lymphopoiesis in secondary lymphoid tissue.	FCER1G DOCK10	1.85e-05	3	87	2	27502165
Pubmed	Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness.	DDX17 DDX5	1.85e-05	3	87	2	23022728
Pubmed	RNA helicase DDX5 suppresses IFN-I antiviral innate immune response by interacting with PP2A-Cβ to deactivate IRF3.	IRF3 DDX5	1.85e-05	3	87	2	33065113
Pubmed	RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation.	DDX17 DDX5	1.85e-05	3	87	2	24910439
Pubmed	The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer.	DDX17 DDX5	1.85e-05	3	87	2	19718048
Pubmed	Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor.	DDX17 DDX5	1.85e-05	3	87	2	22266867
Pubmed	The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner.	DDX17 DDX5	1.85e-05	3	87	2	15298701
Pubmed	Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis.	PSMD2 DDX5 RAD50	1.95e-05	21	87	3	30179224
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	DDX17 SF3B1 DIDO1 ARID1A DDX5 RAD50	1.97e-05	220	87	6	35785414
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	DDX17 SF3B1 MRPL22 NEMF RALGAPB MACF1 DIDO1 DNMT1 RAD50	2.01e-05	601	87	9	33658012
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	YEATS2 FLNB DDX17 PEX19 MACF1 ARID1A DNMT1	2.06e-05	332	87	7	37433992
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	FLNB DDX17 SF3B1 DIDO1 DDX5 DNMT1 RAD50	2.06e-05	332	87	7	32786267
Pubmed	Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner.	PCGF6 DNAH12 SF3B1 CHERP ALMS1 MOB2	2.07e-05	222	87	6	35941108
Pubmed	Tagging genes with cassette-exchange sites.	FLNB DDX17 CHERP UTP25 PEX19 MACF1 DIDO1	2.18e-05	335	87	7	15741177
Pubmed	Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN).	ANKRD31 DNAH12 CYS1 DNMT1	2.20e-05	65	87	4	32120844
Pubmed	Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins.	DDX17 CHERP DDX5	2.25e-05	22	87	3	26420826
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	FLNB DLG5 DDX17 SF3B1 CHERP MRPL22 ACO2 ZFP91 NUFIP2 PSMD2 DDX5	2.49e-05	949	87	11	36574265
Pubmed	Molecular reclassification of Crohn's disease by cluster analysis of genetic variants.	DLG5 DNAH12 IL23R	2.58e-05	23	87	3	20886065
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	YEATS2 DDX17 SF3B1 CHERP ATAD2B NUFIP2 DIDO1 AK6 ARID1A DDX5 DNMT1	2.62e-05	954	87	11	36373674
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	KIFBP SF3B1 SHANK2 NUFIP2 STON2 MFN2 MACF1 DIDO1 TOP3B DNMT1 RAD50	2.85e-05	963	87	11	28671696
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	YEATS2 DDX17 SF3B1 ZFP91 NUFIP2 DIDO1 DDX5	3.27e-05	357	87	7	37059091
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	FLNB DLG5 ALMS1 ZFP91 NUFIP2 CHD6 MED13L MOB2 RAD50	3.48e-05	645	87	9	25281560
Pubmed	The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor.	DDX17 DDX5	3.70e-05	4	87	2	15660129
Pubmed	Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort.	DLG5 IL23R	3.70e-05	4	87	2	18824555
Pubmed	Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions.	DDX17 DDX5	3.70e-05	4	87	2	32463358
Pubmed	NT5C2 methylation regulatory interplay between DNMT1 and insulin receptor in type 2 diabetes.	INSR DNMT1	3.70e-05	4	87	2	32999320
Pubmed	Identification of cytoplasmic proteins interacting with unliganded estrogen receptor α and β in human breast cancer cells.	DDX17 DDX5	3.70e-05	4	87	2	25604459
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	ALMS1 NEMF NUFIP2 ASPM TOP3B CNOT2 RAD50	3.70e-05	364	87	7	24778252
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	ANKRD31 VPS13C MACF1 ADGRV1 ARHGAP19	4.13e-05	152	87	5	34299191
Pubmed	Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.	YEATS2 ARID1A TFCP2 RAD50	4.30e-05	77	87	4	19505873
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	FLNB DLG5 SF3B1 NUFIP2 ASPM DIDO1	4.60e-05	256	87	6	33397691
Pubmed	Genetic risk profiling and prediction of disease course in Crohn's disease patients.	DLG5 DNAH12 IL23R	4.73e-05	28	87	3	19422935
Pubmed	Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers.	FLNB SF3B1 ACO2 PSMD2 ARID1A DNMT1	4.91e-05	259	87	6	31162944
Pubmed	Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress.	DDX17 SF3B1 CHERP DDX5 RAD50	5.12e-05	159	87	5	22751105
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	DLG5 ALMS1 NUFIP2 MACF1 ARID1A DDX5	5.34e-05	263	87	6	34702444
Pubmed	Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU.	DDX17 DDX5	6.16e-05	5	87	2	18279852
Pubmed	Genetic risk for restenosis after coronary stenting.	INSR ROS1	6.16e-05	5	87	2	17275003
Pubmed	Identification of RNA helicases in human immunodeficiency virus 1 (HIV-1) replication - a targeted small interfering RNA library screen using pseudotyped and WT HIV-1.	DDX17 DDX5	6.16e-05	5	87	2	25701821
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	PCGF6 DDX17 SF3B1 PSMD2 MED13L DDX5	6.43e-05	272	87	6	31010829
Pubmed	BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.	SF3B1 DDX5 DNMT1	6.46e-05	31	87	3	23086144
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	YEATS2 PCGF6 MED13L ARID1A TFCP2	6.46e-05	167	87	5	20362541
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	FLNB DLG5 DDX17 SF3B1 MRPL22 NUFIP2 STON2 DIDO1 PSMD2 DDX5 DNMT1 RAD50	6.86e-05	1257	87	12	36526897
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	FLNB DDX17 SF3B1 MYLK ACO2 MACF1 PSMD2 DDX5 DNMT1	7.35e-05	711	87	9	33022573
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	FLNB DDX17 SF3B1 CHERP NUFIP2 PSMD2 DDX5 RAD50	7.36e-05	551	87	8	34728620
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DLG5 DDX17 SF3B1 CHERP ACO2 NEMF MACF1 DIDO1 CHD6 ARID1A DDX5	8.12e-05	1082	87	11	38697112
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FLNB SF3B1 NEMF MACF1 PSMD2 ALAD CHD6 ZNF841 MED13L ARID1A CNOT2 DNMT1	8.46e-05	1285	87	12	35914814
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	DDX17 SF3B1 ACO2 PSMD2 RAD50	8.97e-05	179	87	5	36261009
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	YEATS2 PCGF6 DDX17 SF3B1 CHERP DIDO1 CHD6 ARID1A TFCP2 DDX5 DNMT1 RAD50	9.03e-05	1294	87	12	30804502
Pubmed	Large-scale concatenation cDNA sequencing.	SIRT2 DDX17 SF3B1 SHANK2 ATAD2B TOP3B ARHGAP19 AZIN1	9.08e-05	568	87	8	9110174
Pubmed	Lack of evidence for association of primary sclerosing cholangitis and primary biliary cirrhosis with risk alleles for Crohn's disease in Polish patients.	DLG5 IL23R	9.22e-05	6	87	2	18715515
Pubmed	Distinct DDX DEAD-box RNA helicases cooperate to modulate the HIV-1 Rev function.	DDX17 DDX5	9.22e-05	6	87	2	23608157
Pubmed	The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation.	DDX17 DDX5	9.22e-05	6	87	2	17011493
Pubmed	A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation.	SIRT2 DNAJB5	9.22e-05	6	87	2	20159555
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	YEATS2 DDX17 SF3B1 CHERP MRPL22 ACO2 DIDO1 AK6 PSMD2 CHD6 DDX5 DNMT1	1.07e-04	1318	87	12	30463901
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	DDX17 NEMF NUFIP2 ASPM MACF1 DIDO1 TOP3B DDX5 DNMT1	1.20e-04	759	87	9	35915203
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	KIFBP DDX17 SF3B1 MRPL22 TBCK ZFP91 STON2 MRPL27 PSMD2 TFCP2 DDX5 RAD50	1.21e-04	1335	87	12	29229926
Pubmed	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	DDX17 SF3B1 CHERP NUFIP2 DDX5 DNMT1 RAD50	1.23e-04	441	87	7	31239290
Interaction	AURKB interactions	DLG5 PTPA DDX17 SF3B1 CHERP NUFIP2 MRPL27 MACF1 AK6 PSMD2 ADGRV1 KIAA1586 DDX5 RAD50	3.88e-06	761	86	14	int:AURKB
Interaction	ENTR1 interactions	YEATS2 DLG5 SIRT2 ALMS1 ASPM DNAJB5 CNOT2	1.59e-05	188	86	7	int:ENTR1
GeneFamily	Fibronectin type III domain containing	CHL1 MYLK PTPRM INSR ROS1 FLRT3	1.09e-05	160	57	6	555
Coexpression	GSE12198_CTRL_VS_HIGH_IL2_STIM_NK_CELL_DN	FLNB SIRT2 UTP25 PARP3 PEX19 MRPL27 AZIN1	4.73e-06	200	87	7	M7070
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	DDX17 SF3B1 FCER1G SYTL3 VPS13C NEMF RALGAPB NUFIP2 DOCK10 PHTF2 MACF1 ARID1A CNOT2 DDX5 DNMT1 AZIN1	2.86e-05	1492	87	16	M40023
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP	YEATS2 VPS13C ATAD2B TBCK MACF1 ARID1A	3.07e-05	180	87	6	M8239
Coexpression	GSE40666_STAT1_KO_VS_STAT4_KO_CD8_TCELL_WITH_IFNA_STIM_90MIN_UP	ACO2 PARP3 RALGAPB ZFP91 CNOT2 ARHGAP19	4.81e-05	195	87	6	M9218
Coexpression	GSE8621_LPS_PRIMED_UNSTIM_VS_LPS_PRIMED_AND_LPS_STIM_MACROPHAGE_UP	PTPA MYLK ACO2 FLRT3 DDX5 MOB2	5.38e-05	199	87	6	M6973
Coexpression	GSE14308_TH1_VS_NAIVE_CD4_TCELL_DN	PCGF6 PHTF2 ZNF841 MED13L CNOT2 DDX5	5.53e-05	200	87	6	M3377
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DDX17 SF3B1 VPS13C ATAD2B NUFIP2 MACF1 MED13L DDX5	5.73e-09	200	87	8	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	DNAH12 SHANK2 NEBL ASPM SAXO2 MACF1 CMAHP	1.16e-07	196	87	7	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	DNAH12 SHANK2 NEBL ASPM SAXO2 MACF1 CMAHP	1.16e-07	196	87	7	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	COVID-19-kidney-CD-IC-B\|COVID-19 / Disease (COVID-19 only), tissue and cell type	EPS8 DLG5 SHANK2 NEBL SULT1C2 ADCY1	1.55e-06	182	87	6	ee6a8c356bbbdae55e4ea858337e079491f9f4aa
ToppCell	COPD-Epithelial-ATII\|COPD / Disease state, Lineage and Cell class	SHANK2 NEBL ROS1 FLRT3 ADGRV1 CMAHP	1.87e-06	188	87	6	eb6d79d733b53f64ca615bb777c64ed456866549
ToppCell	COPD-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	DNAH12 SHANK2 NEBL SYTL3 ASPM CMAHP	1.87e-06	188	87	6	186fe1ea328c942910190a4240262c0d8642ea3b
ToppCell	IPF-Epithelial-Club\|IPF / Disease state, Lineage and Cell class	CHL1 SHANK2 NEBL ROS1 FLRT3 CMAHP	1.93e-06	189	87	6	f3fcef008ef252b29ac6d567fef27f9acf9cd70f
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	DDX17 VPS13C TBCK DOCK10 MACF1 ZNF841	2.05e-06	191	87	6	9454f642c3621370fa23640b631301346b300950
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SHANK2 SULT1C2 SYTL3 STON2 ADGRV1 FRMD3	2.12e-06	192	87	6	b99f8236ef4ccdc75c02abea381cae6453205f6f
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PITPNM2 EPS8 SHANK2 NEBL ROS1 ADGRV1	2.25e-06	194	87	6	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	EPS8 SHANK2 NEBL PTPRM ROS1 ADGRV1	2.31e-06	195	87	6	9406866f99555198a9be311fbd65751b70f35446
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SF3B1 ACO2 NUFIP2 PSMD2 DDX5 AZIN1	2.38e-06	196	87	6	151f1a29a91f8b234e9b6ed062666357a2f69128
ToppCell	(04)_Interm._basal>secr.-(2)_GFP_FOXI1\|(04)_Interm._basal>secr. / shred by cell type by condition	EPS8 REXO2 VPS13C ACO2 INSR RAD50	2.60e-06	199	87	6	53ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	EPS8 REXO2 VPS13C ACO2 INSR RAD50	2.60e-06	199	87	6	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	Control-Epithelial_cells-ECM-high_epithelial\|Control / group, cell type (main and fine annotations)	FLNB SHANK2 NEBL PTPRM ADGRV1	2.09e-05	170	87	5	e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CHL1 CYS1 MYLK NEBL ADGRV1	2.34e-05	174	87	5	46bd0ef7d0541386de7a901d85d53d0176dc92bf
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHL1 TBCK KANK4 FLRT3 ADCY1	2.75e-05	180	87	5	da723df348d7b8449bb1124f23fe6fa706412adb
ToppCell	droplet-Heart-nan-3m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHL1 TBCK KANK4 FLRT3 ADCY1	2.75e-05	180	87	5	5b146a94708b3c3610542a4d0925f3f7a2b19185
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHL1 TBCK KANK4 FLRT3 ADCY1	2.75e-05	180	87	5	50758b1e7be2e43f83c10ab106900c067e61f5f7
ToppCell	facs-Marrow-T-cells-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB FCER1G SYTL3 VPS13C DOCK10	2.82e-05	181	87	5	7286700396676fdc41d9723979b8b408177aceb9
ToppCell	Control-Epithelial_cells-Airway_club\|Control / group, cell type (main and fine annotations)	CHL1 EPS8 SHANK2 ROS1 ADGRV1	2.82e-05	181	87	5	c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCell	COVID-19-Epithelial_cells-ECM-high_epithelial\|COVID-19 / group, cell type (main and fine annotations)	FLNB SHANK2 NEBL ROS1 ADGRV1	2.97e-05	183	87	5	dc1d380bf7564f290256cb7108063d1bd2da732b
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	YEATS2 DOCK10 AK6 ZNF582 IL23R	2.97e-05	183	87	5	310ad42b2b5d8ddd01d3a12db338f80ac1f5d08e
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	EPS8 SHANK2 NEBL ROS1 ADGRV1	2.97e-05	183	87	5	6847c1252d6bb105524f812658112517fd351eab
ToppCell	COPD-Epithelial-ATII\|World / Disease state, Lineage and Cell class	SHANK2 NEBL ROS1 ADGRV1 CMAHP	2.97e-05	183	87	5	8e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	YEATS2 DOCK10 AK6 ZNF582 IL23R	2.97e-05	183	87	5	fef51dcf180e6d4e136362c7e140ec5ef372e6d0
ToppCell	COVID-19-Epithelial_cells-AT2\|COVID-19 / group, cell type (main and fine annotations)	EPS8 SHANK2 NEBL ROS1 ADGRV1	3.05e-05	184	87	5	369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	REXO2 CCNYL1 PTPRM KANK4 FRMD3	3.13e-05	185	87	5	f98af3146ec2f44c30d31a662fb9c4fa3ca4f706
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	SHANK2 PTPRM TBCK KANK4 MED13L	3.13e-05	185	87	5	1d874608aa2062024323512f68889219471b2f00
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet-Platelet-plt_4\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CCNYL1 DNAH12 MYLK STON2 FRMD3	3.13e-05	185	87	5	709236097cbfc254796fcc69b5f5178b73dad9bd
ToppCell	Control-Epithelial-Club\|World / Disease state, Lineage and Cell class	SHANK2 NEBL ROS1 FLRT3 CMAHP	3.21e-05	186	87	5	9798428691408e17ff2af2fe2d1b345f074d67e4
ToppCell	COPD-Epithelial-Club\|World / Disease state, Lineage and Cell class	SHANK2 NEBL ROS1 ADGRV1 CMAHP	3.21e-05	186	87	5	3006f4ab1eaf1eb34c10ca9f7c869603d2d25744
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	VPS13C NUFIP2 DOCK10 MACF1 MED13L	3.38e-05	188	87	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CHL1 SHANK2 NEBL SYTL3 ADGRV1	3.38e-05	188	87	5	af740fa78542438fdff627ea1f74f4eee43316be
ToppCell	Control-Epithelial_cells\|Control / group, cell type (main and fine annotations)	EPS8 SHANK2 NEBL ROS1 ADGRV1	3.38e-05	188	87	5	707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCell	(2)_NK/T-(210)_NKT_cell\|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)	FCER1G SYTL3 NUFIP2 MACF1 IRF3	3.47e-05	189	87	5	fa72e87e1e8cd7cbddae7b47e19cf90d181820a7
ToppCell	COVID-19-lung-Secretory\|lung / Disease (COVID-19 only), tissue and cell type	EPS8 FLNB SHANK2 INSR ADGRV1	3.47e-05	189	87	5	84d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCell	(2)_NK/T-(21)_NKT_cell\|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)	FCER1G SYTL3 NUFIP2 MACF1 IRF3	3.47e-05	189	87	5	b37ad24898a14a4a3b2d6cea2637de2471f76e20
ToppCell	Control-Epithelial-ATII\|Control / Disease state, Lineage and Cell class	SHANK2 NEBL ROS1 FLRT3 CMAHP	3.56e-05	190	87	5	d50902a3abcc18aafa36d83cc2c6e07d7f7cb197
ToppCell	COPD-Epithelial-Club\|COPD / Disease state, Lineage and Cell class	SHANK2 NEBL ROS1 ADGRV1 CMAHP	3.65e-05	191	87	5	c909cf5fa0e6519aa93a47d2c3fcd2ae2163cd8d
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2\|Children_(3_yrs) / Lineage, Cell type, age group and donor	EPS8 SHANK2 NEBL ROS1 ADGRV1	3.65e-05	191	87	5	a0332a4ef629510fb313ec119195c44a3f704a80
ToppCell	Control-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	SHANK2 NEBL ROS1 FLRT3 CMAHP	3.74e-05	192	87	5	1bfd022d5b87cf8a5d5069f559339a553a52a0a2
ToppCell	COPD-Epithelial\|COPD / Disease state, Lineage and Cell class	SHANK2 NEBL SAXO2 ROS1 ADGRV1	3.74e-05	192	87	5	0644fad5df18f0021f6f49cca996d8cf47f972ff
ToppCell	Epithelial-alveolar_epithelial_cell_type_2\|World / Lineage, Cell type, age group and donor	EPS8 SHANK2 NEBL ROS1 ADGRV1	3.74e-05	192	87	5	58c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	SHANK2 PTPRM INSR MACF1 MED13L	3.74e-05	192	87	5	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	human_hepatoblastoma-Tumor_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	FLNB DLG5 SHANK2 DIDO1 CHD6	3.83e-05	193	87	5	503a979328c68b096680b71359a26f02fafdff35
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHANK2 NEBL PTPRM ROS1 ADGRV1	3.93e-05	194	87	5	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	Control-Epithelial\|Control / Disease state, Lineage and Cell class	SHANK2 NEBL ROS1 FLRT3 ADGRV1	4.02e-05	195	87	5	1798c3b89b1b5ff4f5777d2b9f52dc81cdad28fa
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	SHANK2 NEBL PTPRM ADGRV1 MED13L	4.12e-05	196	87	5	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	facs-Skin-Telogen-3m-Epithelial-bulge_keratinocyte\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB MACF1 FLRT3 ADCY1 AZIN1	4.12e-05	196	87	5	90edf61116ffcb4f8b6be3d0a05732d59b0a87d5
ToppCell	facs-Skin-Telogen-3m-Epithelial-outer_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPS8 FLNB MACF1 ADCY1 AZIN1	4.12e-05	196	87	5	c936014125b2ed5f796221b74acb77b8f8359875
ToppCell	moderate-Lymphoid-Treg\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DDX17 VPS13C PHTF2 MACF1 IL23R	4.12e-05	196	87	5	9152f4a8a27ff4ee28f231c5ad00eb2edd9ea6da
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	NEMF MRPL27 ASPM DNMT1 RAD50	4.22e-05	197	87	5	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	EPS8 SHANK2 NEBL ROS1 ADGRV1	4.33e-05	198	87	5	f948391296c261c473d339069a6d0f20ccd6f38f
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	SHANK2 NEBL PTPRM ADGRV1 MED13L	4.33e-05	198	87	5	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	EPS8 REXO2 VPS13C INSR RAD50	4.33e-05	198	87	5	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	moderate-Lymphoid-CTL\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DDX17 SYTL3 VPS13C MACF1 DDX5	4.33e-05	198	87	5	0a868098b1ee4b28b2149ed766acb09e9c0ce14c
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CHL1 FLNB SHANK2 INSR HS3ST1	4.33e-05	198	87	5	fab3135f03cf23a9f04f0eed543a9dc181f39f5f
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SHANK2 NEBL PTPRM ROS1 ADGRV1	4.43e-05	199	87	5	725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DDX17 SYTL3 ATAD2B MACF1 DDX5	4.43e-05	199	87	5	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	(10)_Ciliated-(2)_GFP_FOXI1\|(10)_Ciliated / shred by cell type by condition	REXO2 VPS13C NEMF INSR RAD50	4.43e-05	199	87	5	61b1ed2db71b96157b92b7535d1955a4033098da
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	PITPNM2 FLNB DDX17 PTPRM MACF1	4.54e-05	200	87	5	eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ANKRD31 STON2 MACF1 ETNPPL ADGRV1	4.54e-05	200	87	5	07d942803360e1a1e8e131d6e31c726dd0db1a0b
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PITPNM2 MYLK SULT1C2 PTPRM MACF1	4.54e-05	200	87	5	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Alv_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PITPNM2 SULT1C2 PTPRM KANK4 MOB2	4.54e-05	200	87	5	b7533c571eeea0cb3678e1a57d3dc036fa8d0f49
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / Treatment groups by lineage, cell group, cell type	EPS8 REXO2 FLNB PTPRM MOB2	4.54e-05	200	87	5	b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Fam19a1_Tmem182\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	EPS8 PTPRM DOCK10 FLRT3	1.03e-04	124	87	4	690595d710b57b7cff8029a3bb06a8dd7e3c03c1
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	DDX17 SYTL3 NUFIP2 MACF1	1.97e-04	147	87	4	94998bc40f5c08295cfe3bdcbe43f13b1e564b3d
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CHL1 PTPRM DOCK10 FLRT3	2.24e-04	152	87	4	8ff5a178a8f3550d89a003c0858820aab3773386
ToppCell	Children_(3_yrs)-Immune-mast_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ANKRD31 SYTL3 DOCK10 IL23R	2.30e-04	153	87	4	d3fb83ca984c7583b1e51c364be6c7c17f67b048
ToppCell	ileum-BEST4+_Enterocytes\|ileum / shred on tissue and cell subclass	CCNYL1 PHTF2 CMAHP HS3ST1	2.36e-04	154	87	4	608e9c982125e0c2c15b86b1920813845a0db81f
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNB CCNYL1 ASPM FRMD3	2.41e-04	155	87	4	8e239470799426ea474a36f57e1b7e0d9365ca5f
ToppCell	Smart-seq2-spleen_(Smart-seq2)-hematologic-thrombocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PITPNM2 MYLK STON2 FRMD3	2.92e-04	163	87	4	ee3b11e6544d4eac38ca045179ebeace6bede237
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1\|E16.5-samps / Age Group, Lineage, Cell class and subclass	NEBL VPS13C MACF1 MED13L	2.92e-04	163	87	4	f1ec2625b52664308968b01d8e0275e1e0751480
ToppCell	Smart-seq2-spleen_(Smart-seq2)-hematologic-thrombocytic-platelet\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PITPNM2 MYLK STON2 FRMD3	2.92e-04	163	87	4	c13af6895dc83b8c3bd52b8e1859818fabf85d0e
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FCER1G SYTL3 ASPM ARHGAP19	2.99e-04	164	87	4	ae09e5aabd1347b865474255e7411c04f63efb3b
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage-IM\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPS8 FCER1G ASPM ARHGAP19	3.06e-04	165	87	4	cece16b03282d27fb49102eb9c104a2024efd28c
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ANKRD31 PCGF6 SYTL3 ASPM	3.21e-04	167	87	4	abc4ba308ca3be41b0da604f5d82579fd58dff7b
ToppCell	Control\|World / group, cell type (main and fine annotations)	SHANK2 NEBL ROS1 ADGRV1	3.28e-04	168	87	4	a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PITPNM2 SHANK2 NEBL ADGRV1	3.43e-04	170	87	4	a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CCNYL1 MYLK ROS1 CMAHP	3.43e-04	170	87	4	5de2f7d16a05af74ebfb1ca42d0f9c3c3524692d
ToppCell	droplet-Liver-nan-3m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRM KIAA0586 STON2 ARHGAP19	3.59e-04	172	87	4	f814b6134ad608015765399d54cc1e5e1873ed34
ToppCell	367C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	SCN11A NEBL FLRT3 ADGRV1	3.59e-04	172	87	4	a9e65201ad9ab4f64251aba2c0bb3d8f9e0193b6
ToppCell	367C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|367C / Donor, Lineage, Cell class and subclass (all cells)	SCN11A NEBL FLRT3 ADGRV1	3.59e-04	172	87	4	26006967d0c82f7bd9b36a18e97a1b93e856aa67
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNB PCGF6 CCNYL1 AZIN1	3.66e-04	173	87	4	4968712af1cca8c932abd3323631d7dcaffd4a66
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MYLK FCER1G SYTL3 SAXO2	3.66e-04	173	87	4	5295ed31648abf8edff214cf67cd4769f20f9e6d
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MYLK NEBL DOCK10 MACF1	3.75e-04	174	87	4	3c47d069bd836599a8d40eae485c23d4d3487517
ToppCell	COVID-19_Convalescent\|World / Disease Group and Platelet Clusters	FLNB CCNYL1 ZNF529 FRMD3	3.83e-04	175	87	4	e9b1faa4c85537f30306619a2f3ada6c8ef0ac6c
ToppCell	droplet-Fat-Mat-18m-Hematologic-monocyte\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCGF6 SYTL3 STON2 TFCP2	3.91e-04	176	87	4	867936a20f73f638055c19c8d88834aa2cc657cf
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-early_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPS8 MYLK PTPRM DNAJB5	3.91e-04	176	87	4	7292e014b8f697f0c2e9f47c48333de95cb44a69
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D122\|Adult / Lineage, Cell type, age group and donor	PITPNM2 SHANK2 FLRT3 ADGRV1	3.91e-04	176	87	4	3fee8a367bb9755aca1b7fcc968b08e51b6e9436
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 DLG5 NEBL ADCY1	3.91e-04	176	87	4	6c7edf1cb38644500bce6c5a1dd90bbe17415cdb
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-early_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPS8 MYLK PTPRM DNAJB5	3.91e-04	176	87	4	88ca2f83d8301633232735f39b0683efe49d0b86
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CHL1 EPS8 SHANK2 ADGRV1	3.91e-04	176	87	4	3bbac5c2397535631fce8fa98f6ddb4fe0260351
ToppCell	(9)_Platelet\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	DNAH12 MYLK STON2 FRMD3	4.00e-04	177	87	4	0830944c43de300815831a9e2b2fce40965e7d12
ToppCell	(9)_Platelet\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	DNAH12 MYLK STON2 FRMD3	4.00e-04	177	87	4	e63d01c7fce4fa1256212fa7e95f74281edb3a01
ToppCell	PBMC-Severe-cDC_11\|Severe / Compartment, Disease Groups and Clusters	FLNB MYLK HS3ST1 ADCY1	4.08e-04	178	87	4	0667abc05eb2254710b9c648c65b7cfdfe7831b7
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UTP25 SYTL3 KIAA0586 PHTF2	4.08e-04	178	87	4	09d2687e0d79f12e90af35fc1c0453d249cf2d19
ToppCell	COVID-19-Epithelial_cells-AT1\|COVID-19 / group, cell type (main and fine annotations)	SHANK2 NEBL FLRT3 ADGRV1	4.17e-04	179	87	4	a0b33bd69ffdfd5d38d80207fb40058a490aa19e
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	EPS8 SHANK2 ROS1 ADGRV1	4.17e-04	179	87	4	815b959ce8721c5ded70c0ca6e318dafc691746e
Computational	Neighborhood of BMPR2	DLG5 DDX17 TBCK RALGAPB MACF1	6.41e-05	85	54	5	GCM_BMPR2
Disease	Hereditary Sensory Autonomic Neuropathy, Type 5	SCN11A DNMT1	1.71e-04	7	85	2	C0020075
Disease	age at menopause	PITPNM2 DDX17 DOCK10 DIDO1 CHD6 TOP3B	2.43e-04	302	85	6	EFO_0004704
Disease	abdominal obesity-metabolic syndrome (implicated_via_orthology)	DDX17 DDX5	3.64e-04	10	85	2	DOID:0060611 (implicated_via_orthology)
Disease	monocyte count	FLNB NUFIP2 DOCK10 DIDO1 PSMD2 ADGRV1 POTEA MED13L CMAHP WIPF2 NENF DNMT1	3.92e-04	1320	85	12	EFO_0005091
Disease	acute myeloid leukemia (implicated_via_orthology)	SF3B1 ZFP91	5.31e-04	12	85	2	DOID:9119 (implicated_via_orthology)
Disease	DEAFNESS, AUTOSOMAL RECESSIVE (disorder)	EPS8 ADCY1	6.27e-04	13	85	2	C1846647
Disease	Mental Retardation, Psychosocial	CHL1 KIFBP SHANK2 MED13L	7.11e-04	139	85	4	C0025363
Disease	Profound Mental Retardation	CHL1 KIFBP SHANK2 MED13L	7.11e-04	139	85	4	C0020796
Disease	Mental deficiency	CHL1 KIFBP SHANK2 MED13L	7.11e-04	139	85	4	C0917816
Disease	granulocyte percentage of myeloid white cells	FLNB DOCK10 PSMD2 MED13L ARID1A	1.08e-03	268	85	5	EFO_0007997
Disease	cancer (implicated_via_orthology)	DDX17 KANK4 MACF1 ARID1A DDX5	1.08e-03	268	85	5	DOID:162 (implicated_via_orthology)
Disease	blood metabolite measurement	PTPA ALMS1	1.36e-03	19	85	2	EFO_0005664
Disease	bipolar disorder, schizophrenia, response to lithium ion	CMAHP ADCY1	1.51e-03	20	85	2	GO_0010226, MONDO_0004985, MONDO_0005090
Disease	Mechanical Allodynia	SCN11A INSR MFN2	1.86e-03	84	85	3	C2936719
Disease	Allodynia	SCN11A INSR MFN2	1.86e-03	84	85	3	C0458247
Disease	Hyperalgesia, Secondary	SCN11A INSR MFN2	1.86e-03	84	85	3	C0751212
Disease	Hyperalgesia, Primary	SCN11A INSR MFN2	1.86e-03	84	85	3	C0751211
Disease	Hyperalgesia, Thermal	SCN11A INSR MFN2	1.86e-03	84	85	3	C0751214
Disease	Tactile Allodynia	SCN11A INSR MFN2	1.86e-03	84	85	3	C0751213
Disease	Hyperalgesia	SCN11A INSR MFN2	1.86e-03	84	85	3	C0020429
Disease	age of onset of childhood onset asthma	PITPNM2 FCER1G ACO2	2.41e-03	92	85	3	OBA_2001015
Disease	alcohol use disorder (implicated_via_orthology)	EPS8 DDX17 ARID1A ADCY1	2.47e-03	195	85	4	DOID:1574 (implicated_via_orthology)
Disease	response to norepinephrine-dopamine reuptake inhibitor	ADGRV1 HS3ST1	2.55e-03	26	85	2	EFO_0007870
Disease	childhood onset asthma	PITPNM2 FCER1G ACO2 INSR RAD50	2.82e-03	334	85	5	MONDO_0005405

Protein segments in the cluster

Peptide	Gene	Start	Entry
DPADYNKIHPVDKLT	ACO2	711	Q99798
KKPERPAAISYDHSE	CYS1	131	Q717R9
YHPDKNKEPNAEEKF	DNAJB5	31	O75953
KEPVDEDLYPEHYRK	DNMT1	961	P26358
PEVHKKYKEDEPLFT	AZIN1	336	O14977
DEFPTNLPKYVKELH	FLRT3	96	Q9NZU0
PYFVITHEERNEEKP	ADGRV1	3321	Q8WXG9
EKPDIFYQKDLPDRH	ALMS1	2146	Q8TCU4
PERFKERGYQLKPHE	AADACL3	291	Q5VUY0
PLTREKVPEEYFKHD	CCNYL1	171	Q8N7R7
KEKEDFHSYLPIIDP	ASPM	536	Q8IZT6
KKEFVHVAPTPDTYR	ETNPPL	161	Q8TBG4
YEEEIIHFKKELREP	RAD50	1081	Q92878
KTVEEVPHPLDRDYQ	PARP3	306	Q9Y6F1
YKEEIVHQLPSNKPE	AK6	136	Q9Y3D8
KPAAEERKAYLEPEH	MOB2	16	Q70IA6
HPERKQAPLTYEKEE	ARID1A	2021	O14497
NHVELFKKPQDYIPR	ANKRD31	1026	Q8N7Z5
FLEAVAEEKPHVKPY	MYLK	1796	Q15746
PEEIKDFSYVHKVPS	MED13L	926	Q71F56
YSVKEKEDLHPDPEI	CHL1	1111	O00533
DKPVEDILTYEEFHP	NEMF	261	O60524
PYLDIVREVKDKHPD	ALAD	256	P13716
EYNPDKDPGDKIIRH	ATAD2B	1036	Q9ULI0
LPKFEKNFYQEHPDL	DDX5	51	P17844
DTEHIVKEAPNKYPL	FSIP2	1206	Q5CZC0
SELEPDKYAVRFIPH	FLNB	2336	O75369
SKAKEPHFEYIEQPI	KIAA1586	101	Q9HCI6
RNQETYETLKHEKPP	FCER1G	71	P30273
DRPYVEEPRHVKVQK	DLG5	1341	Q8TDM6
REIYDSKEPHNAKFP	DNAH12	2421	Q6ZR08
LDFKPEDQPHFDIKD	NENF	156	Q9UMX5
YKRKNIEPTHAPFIE	MACF1	3071	O94854
SPEEHRPFEKVVNKE	INSR	791	P06213
IDIVKDPVPHNEYKT	PITPNM2	141	Q9BZ72
EYIDPETKKHIPYRE	CSNK1G3	191	Q9Y6M4
DFHPSPVVLKVYKNE	MFN2	451	O95140
PEEYEFAPKKAASHR	REXO2	181	Q9Y3B8
HRESLPPEQFEKYQE	PEX19	206	P40855
FYPHEPLKIKEELTR	FRMD3	111	A2A2Y4
EDFLKPPERIFHKIY	ADCY1	281	Q08828
EYKPEKLPSHSFEID	DOCK10	141	Q96BY6
LEDHEYKPLDPKDIR	CHERP	661	Q8IWX8
TKDEQKHRRPYEFEV	CHD6	2171	Q8TD26
KHYPDGRKEITFPDQ	CENPJ	1236	Q9HC77
EIKEIFIPEHKPTDY	IL23R	436	Q5VWK5
FIPEHKPTDYKKENT	IL23R	441	Q5VWK5
KDPHGEKREFQDAPY	DIDO1	1846	Q9BTC0
EVPHSKAERYKPSEE	KANK4	736	Q5T7N3
FEKPRQYHEQEETPE	EPS8	246	Q12929
ELPKFEKNFYVEHPE	DDX17	126	Q92841
RVELHKNPEKEPYKS	KIFBP	21	Q96EK5
VQSHTYKKREPADVP	PTPRM	856	P28827
HDFYKERGLEVPKPA	PCGF6	211	Q9BYE7
FPNTEIEEYHRPEKK	POTEA	386	Q6S8J7
RSKDPHDPHKIYEFV	IRF3	96	Q14653
EPPKTAVAHAKEYIQ	MRPL22	181	Q9NWU5
QKHKPYPSIEEFLVR	HS3ST1	166	O14792
HPLRAKAEKYEDSVP	SYTL3	431	Q4VX76
HPFYDRVSRKEAKPQ	UTP25	31	Q68CQ4
INPCVKKEYRDDPFH	PHTF2	431	Q8N3S3
EPKVPDDIYKTHLEN	PSMD2	341	Q13200
EAIFEISYFKKHPEP	SIRT2	116	Q8IXJ6
KYQPKPAVAHTAERE	STON2	511	Q8WXE9
HKETDIVPFREAPAY	SHANK2	386	Q9UPX8
SFPKERPQREHPYEE	CMAHP	396	Q9Y471
AKEFHLEYDKLEERP	CNOT2	511	Q9NZN8
VERHDKIQSFKPETY	TOP3B	226	O95985
TEHPVFPKAYELEKR	NUFIP2	556	Q7Z417
KRTPHEKEKYQPSYE	TFCP2	256	Q12800
PYLEPRHFVDEKAVN	PTPA	266	Q15257
EHRPPKIADREDEYK	SF3B1	106	O75533
FLFYEDIKRDPKHEI	SULT1C2	191	O00338
IHIKYEDDVTDPKRP	VPS13C	201	Q709C8
VFDVDLEHKVKYPRE	ROS1	1251	P08922
NPDFFVEKLRHEKPE	ARHGAP19	41	Q14CB8
IHAKYDAIDKDTPIP	TBCK	486	Q8TEA7
YSVKHRPFPEEVDKI	RALGAPB	1021	Q86X10
RHVPEEYKPKQGKID	SAXO2	31	Q658L1
KELFPKQHVYEVESP	ZNF582	86	Q96NG8
LPTQDEKTHIREKPY	ZNF841	131	Q6ZN19
KPLEDLDPFYRNHKT	SCN11A	76	Q9UI33
FKDDPRDETYKPHLE	ZFP91	226	Q96JP5
RDETYKPHLERETPK	ZFP91	231	Q96JP5
PRRTHDSEKPYEYKE	ZNF529	161	Q6P280
EDFPAPEEYKHFQRI	WIPF2	406	Q8TF74
KEVYVPHPRNTEAVD	MRPL27	101	Q9P0M9
RAVEKYSVKPEHPNL	KIAA0586	276	Q9BVV6
QEEKQEEVKFYLPPT	YEATS2	1311	Q9ULM3
YKEEIKHATAISDPP	NEBL	626	O76041