Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR2	8.42e-07	4	8	2	GO:0005219
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR2	2.11e-06	6	8	2	GO:0048763
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR1 RYR2	2.14e-05	18	8	2	GO:0015278
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	RYR1 RYR2	6.49e-05	31	8	2	GO:0099604
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	RYR1 RYR2	7.37e-05	33	8	2	GO:0005217
GeneOntologyMolecularFunction	calcium channel activity	RYR1 RYR2	1.13e-03	129	8	2	GO:0005262
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	RYR1 RYR2	1.33e-03	140	8	2	GO:0099094
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	RYR1 RYR2	1.54e-03	151	8	2	GO:0015085
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	RYR1 RYR2	2.50e-03	193	8	2	GO:0015276
GeneOntologyMolecularFunction	calcium ion binding	RYR1 RYR2 ITSN2	2.56e-03	749	8	3	GO:0005509
GeneOntologyMolecularFunction	ligand-gated channel activity	RYR1 RYR2	2.61e-03	197	8	2	GO:0022834
GeneOntologyMolecularFunction	calmodulin binding	RYR1 RYR2	3.53e-03	230	8	2	GO:0005516
GeneOntologyMolecularFunction	gated channel activity	RYR1 RYR2	7.31e-03	334	8	2	GO:0022836
GeneOntologyMolecularFunction	monoatomic cation channel activity	RYR1 RYR2	7.69e-03	343	8	2	GO:0005261
GeneOntologyMolecularFunction	transmembrane transporter activity	RYR1 RYR2 MFSD1	9.21e-03	1180	8	3	GO:0022857
GeneOntologyMolecularFunction	transporter activity	RYR1 RYR2 MFSD1	1.18e-02	1289	8	3	GO:0005215
GeneOntologyMolecularFunction	monoatomic ion channel activity	RYR1 RYR2	1.35e-02	459	8	2	GO:0005216
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	RYR1 RYR2	1.38e-02	465	8	2	GO:0046873
GeneOntologyMolecularFunction	channel activity	RYR1 RYR2	1.74e-02	525	8	2	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	RYR1 RYR2	1.75e-02	526	8	2	GO:0022803
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	RYR1 RYR2	2.43e-02	627	8	2	GO:0022890
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	RYR1 RYR2	2.71e-02	664	8	2	GO:0008324
GeneOntologyBiologicalProcess	cellular response to caffeine	RYR1 RYR2	9.29e-06	11	9	2	GO:0071313
GeneOntologyBiologicalProcess	cellular response to purine-containing compound	RYR1 RYR2	1.54e-05	14	9	2	GO:0071415
GeneOntologyBiologicalProcess	response to caffeine	RYR1 RYR2	3.54e-05	21	9	2	GO:0031000
GeneOntologyBiologicalProcess	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	RYR1 RYR2	1.12e-04	37	9	2	GO:0014808
GeneOntologyBiologicalProcess	release of sequestered calcium ion into cytosol by endoplasmic reticulum	RYR1 RYR2	1.24e-04	39	9	2	GO:1903514
GeneOntologyBiologicalProcess	cellular response to alkaloid	RYR1 RYR2	1.31e-04	40	9	2	GO:0071312
GeneOntologyBiologicalProcess	sarcoplasmic reticulum calcium ion transport	RYR1 RYR2	1.59e-04	44	9	2	GO:0070296
GeneOntologyBiologicalProcess	response to hypoxia	RYR1 RYR2 AGTRAP	3.71e-04	348	9	3	GO:0001666
GeneOntologyBiologicalProcess	response to decreased oxygen levels	RYR1 RYR2 AGTRAP	4.23e-04	364	9	3	GO:0036293
GeneOntologyBiologicalProcess	regulation of cytosolic calcium ion concentration	RYR1 RYR2	5.79e-04	84	9	2	GO:0051480
GeneOntologyBiologicalProcess	response to oxygen levels	RYR1 RYR2 AGTRAP	6.88e-04	430	9	3	GO:0070482
GeneOntologyBiologicalProcess	response to alkaloid	RYR1 RYR2	1.28e-03	125	9	2	GO:0043279
GeneOntologyBiologicalProcess	release of sequestered calcium ion into cytosol	RYR1 RYR2	1.73e-03	146	9	2	GO:0051209
GeneOntologyBiologicalProcess	negative regulation of sequestering of calcium ion	RYR1 RYR2	1.76e-03	147	9	2	GO:0051283
GeneOntologyBiologicalProcess	regulation of sequestering of calcium ion	RYR1 RYR2	1.81e-03	149	9	2	GO:0051282
GeneOntologyBiologicalProcess	response to abiotic stimulus	RYR1 RYR2 OPN5 AGTRAP	1.82e-03	1361	9	4	GO:0009628
GeneOntologyBiologicalProcess	sequestering of calcium ion	RYR1 RYR2	1.90e-03	153	9	2	GO:0051208
GeneOntologyBiologicalProcess	response to calcium ion	RYR1 RYR2	2.10e-03	161	9	2	GO:0051592
GeneOntologyBiologicalProcess	response to purine-containing compound	RYR1 RYR2	2.23e-03	166	9	2	GO:0014074
GeneOntologyBiologicalProcess	regulation of muscle contraction	RYR1 RYR2	3.28e-03	202	9	2	GO:0006937
GeneOntologyBiologicalProcess	cellular response to nitrogen compound	RYR1 RYR2 AGTRAP	3.44e-03	752	9	3	GO:1901699
GeneOntologyBiologicalProcess	striated muscle contraction	RYR1 RYR2	3.78e-03	217	9	2	GO:0006941
GeneOntologyBiologicalProcess	calcium ion transmembrane import into cytosol	RYR1 RYR2	3.78e-03	217	9	2	GO:0097553
GeneOntologyBiologicalProcess	maintenance of location in cell	RYR1 RYR2	5.33e-03	259	9	2	GO:0051651
GeneOntologyBiologicalProcess	calcium-mediated signaling	RYR1 RYR2	5.62e-03	266	9	2	GO:0019722
GeneOntologyBiologicalProcess	regulation of muscle system process	RYR1 RYR2	7.89e-03	317	9	2	GO:0090257
GeneOntologyBiologicalProcess	heart morphogenesis	RYR1 RYR2	8.09e-03	321	9	2	GO:0003007
GeneOntologyBiologicalProcess	intracellular calcium ion homeostasis	RYR1 RYR2	1.00e-02	359	9	2	GO:0006874
GeneOntologyCellularComponent	junctional sarcoplasmic reticulum membrane	RYR1 RYR2	7.40e-06	10	9	2	GO:0014701
GeneOntologyCellularComponent	sarcoplasmic reticulum membrane	RYR1 RYR2	1.62e-04	45	9	2	GO:0033017
GeneOntologyCellularComponent	smooth endoplasmic reticulum	RYR1 RYR2	1.69e-04	46	9	2	GO:0005790
GeneOntologyCellularComponent	extrinsic component of cytoplasmic side of plasma membrane	RYR1 RYR2	2.51e-04	56	9	2	GO:0031234
GeneOntologyCellularComponent	calcium channel complex	RYR1 RYR2	4.26e-04	73	9	2	GO:0034704
GeneOntologyCellularComponent	sarcoplasmic reticulum	RYR1 RYR2	6.19e-04	88	9	2	GO:0016529
GeneOntologyCellularComponent	sarcoplasm	RYR1 RYR2	1.04e-03	114	9	2	GO:0016528
GeneOntologyCellularComponent	extrinsic component of plasma membrane	RYR1 RYR2	1.49e-03	137	9	2	GO:0019897
GeneOntologyCellularComponent	Z disc	RYR1 RYR2	1.80e-03	151	9	2	GO:0030018
GeneOntologyCellularComponent	I band	RYR1 RYR2	2.18e-03	166	9	2	GO:0031674
GeneOntologyCellularComponent	cytoplasmic side of plasma membrane	RYR1 RYR2	2.69e-03	185	9	2	GO:0009898
GeneOntologyCellularComponent	sarcolemma	RYR1 RYR2	2.84e-03	190	9	2	GO:0042383
GeneOntologyCellularComponent	cytoplasmic side of membrane	RYR1 RYR2	4.12e-03	230	9	2	GO:0098562
GeneOntologyCellularComponent	extrinsic component of membrane	RYR1 RYR2	4.12e-03	230	9	2	GO:0019898
GeneOntologyCellularComponent	cation channel complex	RYR1 RYR2	4.30e-03	235	9	2	GO:0034703
GeneOntologyCellularComponent	sarcomere	RYR1 RYR2	4.81e-03	249	9	2	GO:0030017
GeneOntologyCellularComponent	myofibril	RYR1 RYR2	5.76e-03	273	9	2	GO:0030016
GeneOntologyCellularComponent	contractile muscle fiber	RYR1 RYR2	6.47e-03	290	9	2	GO:0043292
GeneOntologyCellularComponent	cell cortex	RYR1 AGTRAP	1.04e-02	371	9	2	GO:0005938
GeneOntologyCellularComponent	monoatomic ion channel complex	RYR1 RYR2	1.08e-02	378	9	2	GO:0034702
GeneOntologyCellularComponent	endoplasmic reticulum membrane	RYR1 RYR2 AGTRAP	1.50e-02	1293	9	3	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	RYR1 RYR2 AGTRAP	1.52e-02	1299	9	3	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	RYR1 RYR2 AGTRAP	1.61e-02	1327	9	3	GO:0042175
GeneOntologyCellularComponent	transmembrane transporter complex	RYR1 RYR2	2.00e-02	523	9	2	GO:1902495
GeneOntologyCellularComponent	transporter complex	RYR1 RYR2	2.20e-02	550	9	2	GO:1990351
HumanPheno	Premature ventricular contraction	RYR1 RYR2	3.13e-05	29	2	2	HP:0006682
HumanPheno	Ventricular tachycardia	RYR1 RYR2	1.81e-04	69	2	2	HP:0004756
HumanPheno	Abnormal electrophysiology of sinoatrial node origin	RYR1 RYR2	2.50e-04	81	2	2	HP:0011702
HumanPheno	Supraventricular tachycardia	RYR1 RYR2	5.50e-04	120	2	2	HP:0004755
HumanPheno	Supraventricular arrhythmia	RYR1 RYR2	6.87e-04	134	2	2	HP:0005115
HumanPheno	Vertigo	RYR1 RYR2	8.16e-04	146	2	2	HP:0002321
HumanPheno	Tachycardia	RYR1 RYR2	1.37e-03	189	2	2	HP:0001649
HumanPheno	Abnormal vestibular function	RYR1 RYR2	1.72e-03	212	2	2	HP:0001751
HumanPheno	Ventricular arrhythmia	RYR1 RYR2	2.38e-03	249	2	2	HP:0004308
HumanPheno	Congestive heart failure	RYR1 RYR2	2.97e-03	278	2	2	HP:0001635
MousePheno	abnormal sarcoplasmic reticulum morphology	RYR1 RYR2	7.21e-05	23	8	2	MP:0004088
MousePheno	abnormal muscle fiber mitochondrial morphology	RYR1 RYR2	1.50e-04	33	8	2	MP:0014342
Domain	RR_TM4-6	RYR1 RYR2	6.19e-07	3	9	2	PF06459
Domain	Ryanrecept_TM4-6	RYR1 RYR2	6.19e-07	3	9	2	IPR009460
Domain	RyR	RYR1 RYR2	6.19e-07	3	9	2	PF02026
Domain	Ryanodine_rcpt	RYR1 RYR2	6.19e-07	3	9	2	IPR003032
Domain	Ryan_recept	RYR1 RYR2	6.19e-07	3	9	2	IPR013333
Domain	RIH_assoc	RYR1 RYR2	3.09e-06	6	9	2	PF08454
Domain	RIH_assoc-dom	RYR1 RYR2	3.09e-06	6	9	2	IPR013662
Domain	Ins145_P3_rec	RYR1 RYR2	3.09e-06	6	9	2	PF08709
Domain	RYDR_ITPR	RYR1 RYR2	3.09e-06	6	9	2	PF01365
Domain	RIH_dom	RYR1 RYR2	3.09e-06	6	9	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR2	3.09e-06	6	9	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR2	3.09e-06	6	9	2	IPR015925
Domain	-	RYR1 RYR2	3.09e-06	6	9	2	1.25.10.30
Domain	MIR	RYR1 RYR2	9.27e-06	10	9	2	PS50919
Domain	MIR	RYR1 RYR2	9.27e-06	10	9	2	PF02815
Domain	MIR	RYR1 RYR2	9.27e-06	10	9	2	SM00472
Domain	MIR_motif	RYR1 RYR2	9.27e-06	10	9	2	IPR016093
Domain	EF-hand_8	RYR1 RYR2	1.15e-04	34	9	2	PF13833
Domain	EF_hand_dom	RYR1 RYR2 ITSN2	1.50e-04	232	9	3	IPR002048
Domain	-	RYR1 RYR2 ITSN2	2.13e-04	261	9	3	1.10.238.10
Domain	EF-hand-dom_pair	RYR1 RYR2 ITSN2	2.82e-04	287	9	3	IPR011992
Domain	SPRY	RYR1 RYR2	7.56e-04	87	9	2	SM00449
Domain	SPRY	RYR1 RYR2	8.82e-04	94	9	2	PF00622
Domain	SPRY_dom	RYR1 RYR2	8.82e-04	94	9	2	IPR003877
Domain	B30.2/SPRY	RYR1 RYR2	9.00e-04	95	9	2	IPR001870
Domain	B302_SPRY	RYR1 RYR2	9.00e-04	95	9	2	PS50188
Domain	Ion_trans_dom	RYR1 RYR2	1.29e-03	114	9	2	IPR005821
Domain	Ion_trans	RYR1 RYR2	1.29e-03	114	9	2	PF00520
Domain	EF-hand_1	RYR2 ITSN2	2.28e-03	152	9	2	PF00036
Domain	EFh	RYR2 ITSN2	2.46e-03	158	9	2	SM00054
Domain	ConA-like_dom	RYR1 RYR2	4.67e-03	219	9	2	IPR013320
Domain	EF_HAND_2	RYR2 ITSN2	5.18e-03	231	9	2	PS50222
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	RYR1 RYR2	8.29e-06	11	6	2	M47958
Pathway	WP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING	RYR1 RYR2	1.18e-05	13	6	2	M39589
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	RYR1 RYR2	2.57e-05	19	6	2	M47760
Pathway	WP_15Q25_COPY_NUMBER_VARIATION	RYR1 RYR2	1.55e-04	46	6	2	M48105
Pathway	REACTOME_ION_HOMEOSTASIS	RYR1 RYR2	2.14e-04	54	6	2	M27460
Pathway	REACTOME_ION_HOMEOSTASIS	RYR1 RYR2	2.14e-04	54	6	2	MM15202
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	RYR1 RYR2	7.19e-04	99	6	2	MM14910
Pathway	REACTOME_CARDIAC_CONDUCTION	RYR1 RYR2	7.78e-04	103	6	2	MM15196
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	RYR1 RYR2	8.24e-04	106	6	2	M27200
Pathway	REACTOME_CARDIAC_CONDUCTION	RYR1 RYR2	1.24e-03	130	6	2	M27454
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	RYR1 RYR2	1.58e-03	147	6	2	MM15854
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	RYR1 RYR2	1.66e-03	151	6	2	M39329
Pathway	WP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS	RYR1 RYR2	1.73e-03	154	6	2	MM15974
Pathway	WP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS	RYR1 RYR2	1.77e-03	156	6	2	M39475
Pathway	REACTOME_MUSCLE_CONTRACTION	RYR1 RYR2	1.98e-03	165	6	2	MM15026
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	RYR1 RYR2	2.25e-03	176	6	2	MM15718
Pathway	KEGG_CALCIUM_SIGNALING_PATHWAY	RYR1 RYR2	2.30e-03	178	6	2	M2890
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	RYR1 RYR2	2.43e-03	183	6	2	M997
Pathway	REACTOME_MUSCLE_CONTRACTION	RYR1 RYR2	2.98e-03	203	6	2	M5485
Pubmed	Structural and functional interactions within ryanodine receptor.	RYR1 RYR2	5.95e-08	2	9	2	26009179
Pubmed	Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.	RYR1 RYR2	5.95e-08	2	9	2	15280431
Pubmed	Expression of the ryanodine receptor isoforms in immune cells.	RYR1 RYR2	5.95e-08	2	9	2	11673493
Pubmed	B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.	RYR1 RYR2	5.95e-08	2	9	2	11673462
Pubmed	Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.	RYR1 RYR2	5.95e-08	2	9	2	18618700
Pubmed	Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.	RYR1 RYR2	5.95e-08	2	9	2	17259277
Pubmed	Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.	RYR1 RYR2	5.95e-08	2	9	2	30542613
Pubmed	Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.	RYR1 RYR2	5.95e-08	2	9	2	32899693
Pubmed	Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.	RYR1 RYR2	5.95e-08	2	9	2	25370123
Pubmed	Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.	RYR1 RYR2	5.95e-08	2	9	2	15033925
Pubmed	Ryanodine receptor oligomeric interaction: identification of a putative binding region.	RYR1 RYR2	5.95e-08	2	9	2	14722100
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR1 RYR2	1.79e-07	3	9	2	25239916
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR2	1.79e-07	3	9	2	7621815
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR2	1.79e-07	3	9	2	9204703
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR1 RYR2	1.79e-07	3	9	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR1 RYR2	1.79e-07	3	9	2	11159936
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR2	1.79e-07	3	9	2	10788707
Pubmed	Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.	RYR1 RYR2	1.79e-07	3	9	2	23278119
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR2	1.79e-07	3	9	2	7876312
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR2	1.79e-07	3	9	2	18434746
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR1 RYR2	1.79e-07	3	9	2	9242641
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR2	1.79e-07	3	9	2	18403125
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR1 RYR2	1.79e-07	3	9	2	10473538
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR2	1.79e-07	3	9	2	21881589
Pubmed	Intracellular calcium release channel expression during embryogenesis.	RYR1 RYR2	1.79e-07	3	9	2	9986730
Pubmed	Dendritic differentiation of cerebellar Purkinje cells is promoted by ryanodine receptors expressed by Purkinje and granule cells.	RYR1 RYR2	1.79e-07	3	9	2	24123915
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR1 RYR2	1.79e-07	3	9	2	7959768
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR2	1.79e-07	3	9	2	12213830
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR1 RYR2	1.79e-07	3	9	2	4600883
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR2	1.79e-07	3	9	2	22948152
Pubmed	Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.	RYR1 RYR2	1.79e-07	3	9	2	23454728
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR1 RYR2	1.79e-07	3	9	2	7635066
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR1 RYR2	3.57e-07	4	9	2	9607712
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR1 RYR2	3.57e-07	4	9	2	9384575
Pubmed	Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+ release.	RYR1 RYR2	3.57e-07	4	9	2	23992453
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR1 RYR2	3.57e-07	4	9	2	18206662
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR1 RYR2	3.57e-07	4	9	2	23482488
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	RYR1 RYR2	3.57e-07	4	9	2	19120137
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 RYR2	3.57e-07	4	9	2	23413940
Pubmed	Increase of ryanodine receptors by dopamine D1 receptors is negatively regulated by γ-aminobutyric acid type B receptors in primary cultures of mouse cerebral cortical neurons.	RYR1 RYR2	3.57e-07	4	9	2	22504960
Pubmed	FKBP binding characteristics of cardiac microsomes from diverse vertebrates.	RYR1 RYR2	3.57e-07	4	9	2	11237759
Pubmed	S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex.	RYR1 RYR2	3.57e-07	4	9	2	27226555
Pubmed	Intracellular calcium-release channels: regulators of cell life and death.	RYR1 RYR2	5.95e-07	5	9	2	9124414
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR1 RYR2	5.95e-07	5	9	2	19011160
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR1 RYR2	5.95e-07	5	9	2	23918386
Pubmed	Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction.	RYR1 RYR2	5.95e-07	5	9	2	22939628
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR1 RYR2	8.92e-07	6	9	2	19549818
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR1 RYR2	8.92e-07	6	9	2	19009018
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 RYR2	8.92e-07	6	9	2	25966694
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 RYR2	8.92e-07	6	9	2	16844763
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR1 RYR2	8.92e-07	6	9	2	26025922
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR1 RYR2	8.92e-07	6	9	2	14592808
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 RYR2	8.92e-07	6	9	2	23463619
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 RYR2	8.92e-07	6	9	2	20519450
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	RYR1 RYR2	1.25e-06	7	9	2	20962236
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR1 RYR2	1.25e-06	7	9	2	11860456
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR1 RYR2	1.67e-06	8	9	2	19033399
Pubmed	Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.	RYR1 RYR2	1.67e-06	8	9	2	11784029
Pubmed	AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.	RYR1 RYR2	2.68e-06	10	9	2	18434328
Pubmed	New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.	RYR1 RYR2	3.92e-06	12	9	2	19095005
Pubmed	MED12 regulates a transcriptional network of calcium-handling genes in the heart.	RYR1 RYR2	5.41e-06	14	9	2	28724790
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	RYR1 RYR2	4.16e-05	38	9	2	30786075
Pubmed	ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.	RYR1 RYR2	9.43e-05	57	9	2	23788249
Interaction	AKAP6 interactions	RYR1 RYR2	1.87e-05	17	8	2	int:AKAP6
Interaction	RYR1 interactions	RYR1 RYR2	1.24e-04	43	8	2	int:RYR1
Interaction	RYR2 interactions	RYR1 RYR2	2.25e-04	58	8	2	int:RYR2
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR2	2.75e-07	3	6	2	287
GeneFamily	EF-hand domain containing	RYR2 ITSN2	2.12e-03	219	6	2	863
Coexpression	PIEPOLI_LGI1_TARGETS_UP	RYR2 FGL2	1.42e-05	17	9	2	M15008
Coexpression	GSE40274_CTRL_VS_FOXP3_AND_PBX1_TRANSDUCED_ACTIVATED_CD4_TCELL_UP	RYR2 ITSN2 FGL2	2.00e-05	165	9	3	M9105
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HMGL	RYR2 ITSN2 MFSD1 FGL2	2.68e-05	577	9	4	M39051
Coexpression	GSE13306_TREG_VS_TCONV_SPLEEN_DN	RYR1 FGL2 AGTRAP	3.50e-05	199	9	3	M3225
Coexpression	TRAVAGLINI_LUNG_CLASSICAL_MONOCYTE_CELL	MFSD1 FGL2 AGTRAP	8.67e-05	270	9	3	M41699
Coexpression	HU_FETAL_RETINA_MICROGLIA	ITSN2 MFSD1 FGL2	2.42e-04	382	9	3	M39266
Coexpression	HAY_BONE_MARROW_NEUTROPHIL	MFSD1 FGL2 AGTRAP	3.91e-04	450	9	3	M39203
Coexpression	NAKAYA_PBMC_FLUMIST_AGE_18_50YO_3DY_UP	MFSD1 FGL2 AGTRAP	7.48e-04	562	9	3	M41008
Coexpression	DESCARTES_FETAL_PLACENTA_MYELOID_CELLS	RYR1 FGL2	1.08e-03	146	9	2	M40285
Coexpression	GSE40274_CTRL_VS_FOXP3_AND_LEF1_TRANSDUCED_ACTIVATED_CD4_TCELL_UP	FGL2 AGTRAP	1.38e-03	165	9	2	M9109
Coexpression	GSE8685_IL15_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP	RYR2 MFSD1	1.38e-03	165	9	2	M337
Coexpression	FOSTER_TOLERANT_MACROPHAGE_UP	FGL2 AGTRAP	1.39e-03	166	9	2	M12595
Coexpression	GSE40274_CTRL_VS_FOXP3_AND_EOS_TRANSDUCED_ACTIVATED_CD4_TCELL_UP	ITSN2 FGL2	1.44e-03	169	9	2	M9102
Coexpression	DESCARTES_FETAL_THYMUS_ANTIGEN_PRESENTING_CELLS	RYR1 FGL2	1.51e-03	173	9	2	M40314
Coexpression	GSE6092_IFNG_VS_IFNG_AND_B_BURGDORFERI_INF_ENDOTHELIAL_CELL_DN	FGL2 AGTRAP	1.55e-03	175	9	2	M6720
Coexpression	FOSTER_TOLERANT_MACROPHAGE_UP	FGL2 AGTRAP	1.76e-03	187	9	2	MM1034
Coexpression	E2F3_UP.V1_UP	RYR1 FAXC	1.82e-03	190	9	2	M2706
Coexpression	CUI_DEVELOPING_HEART_VASCULAR_ENDOTHELIAL_CELL	ITSN2 FGL2	1.88e-03	193	9	2	M39321
Coexpression	GSE45365_NK_CELL_VS_CD8_TCELL_MCMV_INFECTION_UP	MFSD1 FGL2	1.97e-03	198	9	2	M9960
Coexpression	GSE19888_ADENOSINE_A3R_INH_VS_ACT_IN_MAST_CELL_DN	FGL2 MS4A8	1.99e-03	199	9	2	M7341
Coexpression	GSE17721_4H_VS_24H_POLYIC_BMDC_UP	RYR1 FGL2	1.99e-03	199	9	2	M4098
Coexpression	GSE8835_HEALTHY_VS_CLL_CD4_TCELL_UP	RYR1 MS4A8	1.99e-03	199	9	2	M6260
Coexpression	GSE3720_UNSTIM_VS_PMA_STIM_VD2_GAMMADELTA_TCELL_DN	MFSD1 AGTRAP	1.99e-03	199	9	2	M6351
Coexpression	GSE17721_CTRL_VS_LPS_6H_BMDC_DN	FGL2 AGTRAP	1.99e-03	199	9	2	M3692
Coexpression	GSE36527_CD62L_HIGH_VS_CD62L_LOW_TREG_CD69_NEG_KLRG1_NEG_UP	ITSN2 FGL2	2.01e-03	200	9	2	M9023
Coexpression	GSE24634_TEFF_VS_TCONV_DAY3_IN_CULTURE_DN	MFSD1 FGL2	2.01e-03	200	9	2	M4616
Coexpression	GSE36392_EOSINOPHIL_VS_NEUTROPHIL_IL25_TREATED_LUNG_UP	ITSN2 FGL2	2.01e-03	200	9	2	M5282
Coexpression	GSE30962_PRIMARY_VS_SECONDARY_CHRONIC_LCMV_INF_CD8_TCELL_DN	FAXC FGL2	2.01e-03	200	9	2	M5045
Coexpression	GSE44732_UNSTIM_VS_IL27_STIM_IMATURE_DC_UP	RYR1 FGL2	2.01e-03	200	9	2	M9699
Coexpression	GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_UP	RYR1 FGL2	2.01e-03	200	9	2	M6655
Coexpression	GSE23308_CTRL_VS_CORTICOSTERONE_TREATED_MACROPHAGE_MINERALCORTICOID_REC_KO_DN	RYR1 ITSN2	2.01e-03	200	9	2	M7744
Coexpression	GSE22886_NAIVE_CD8_TCELL_VS_MONOCYTE_DN	MFSD1 FGL2	2.01e-03	200	9	2	M4496
Coexpression	GSE22886_NAIVE_TCELL_VS_MONOCYTE_DN	MFSD1 FGL2	2.01e-03	200	9	2	M4480
Coexpression	GSE19888_ADENOSINE_A3R_INH_VS_ACT_WITH_INHIBITOR_PRETREATMENT_IN_MAST_CELL_UP	RYR2 FGL2	2.01e-03	200	9	2	M7322
Coexpression	GSE27786_ERYTHROBLAST_VS_MONO_MAC_DN	MFSD1 AGTRAP	2.01e-03	200	9	2	M4878
Coexpression	GSE5589_WT_VS_IL6_KO_LPS_STIM_MACROPHAGE_45MIN_DN	RYR1 FGL2	2.01e-03	200	9	2	M6639
Coexpression	GSE17721_POLYIC_VS_PAM3CSK4_0.5H_BMDC_DN	FGL2 AGTRAP	2.01e-03	200	9	2	M3823
Coexpression	GSE28737_WT_VS_BCL6_HET_FOLLICULAR_BCELL_DN	FGL2 MS4A8	2.01e-03	200	9	2	M9383
Coexpression	GSE19888_ADENOSINE_A3R_ACT_VS_TCELL_MEMBRANES_ACT_IN_MAST_CELL_UP	MS4A8 AGTRAP	2.01e-03	200	9	2	M7333
Coexpression	AIZARANI_LIVER_C2_KUPFFER_CELLS_1	MFSD1 FGL2	2.01e-03	200	9	2	M39106
Coexpression	HALLMARK_KRAS_SIGNALING_DN	RYR1 RYR2	2.01e-03	200	9	2	M5956
Coexpression	GSE5455_EX_VIVO_VS_POST_24H_INCUBATION_MONOCYTES_FROM_TUMOR_BEARING_MOUSE_DN	RYR1 ITSN2	2.01e-03	200	9	2	M6580
Coexpression	GSE23568_CTRL_TRANSDUCED_VS_WT_CD8_TCELL_UP	RYR1 FGL2	2.01e-03	200	9	2	M8522
Coexpression	GSE22886_NAIVE_CD4_TCELL_VS_MONOCYTE_DN	MFSD1 FGL2	2.01e-03	200	9	2	M4506
Coexpression	GSE22886_NAIVE_CD4_TCELL_VS_DC_DN	MFSD1 FGL2	2.01e-03	200	9	2	M4503
Coexpression	GSE13306_RA_VS_UNTREATED_TCONV_DN	RYR1 MS4A8	2.01e-03	200	9	2	M3235
Coexpression	GSE13306_TREG_VS_TCONV_DN	RYR1 FGL2	2.01e-03	200	9	2	M3230
Coexpression	GSE20366_EX_VIVO_VS_DEC205_CONVERSION_NAIVE_CD4_TCELL_UP	RYR1 FGL2	2.01e-03	200	9	2	M4327
ToppCell	droplet-Liver-LIVER-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 FGL2 MS4A8	3.93e-06	164	9	3	3281f2452cc6b11f3e030a3942002b9457dde6fe
ToppCell	droplet-Liver-LIVER-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 FGL2 MS4A8	3.93e-06	164	9	3	939d4e3911fce185b986639c815de0a0389f6cfd
ToppCell	droplet-Liver-LIVER\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 FGL2 MS4A8	4.15e-06	167	9	3	90125bfdc34b0f9a471cefe6e8a637d5e5e00790
ToppCell	droplet-Liver-LIVER-30m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 FGL2 MS4A8	4.15e-06	167	9	3	4bbc59cc50a68b957125fb11a3b308fe1d542ce9
ToppCell	droplet-Liver-LIVER-30m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 FGL2 MS4A8	4.15e-06	167	9	3	a038c522e4783cb62802f613d00bd5f3e3797199
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	RYR1 MFSD1 FGL2	5.37e-06	182	9	3	d57d18732aa6fb7b2d430601568f9ba525ac6e3c
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	RYR1 MFSD1 FGL2	5.37e-06	182	9	3	9a68d3bd1cc9139de9e9e711c249d47ade826bb1
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	RYR1 MFSD1 FGL2	5.37e-06	182	9	3	c3fb1460160744144aa31afc76c0a4d42ebdeb91
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RYR1 MFSD1 FGL2	5.92e-06	188	9	3	cb091912f9b627a78a8793a37df7f1de839f887f
ToppCell	Fetal_29-31_weeks-Immune-alveolar_macrophage_(MARCO_positive)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RYR1 MFSD1 FGL2	6.41e-06	193	9	3	2d0dd2671ff27b922eb316f1ed0140353536ef30
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-Myeloid-Macrophages\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RYR1 MFSD1 FGL2	6.51e-06	194	9	3	7c7091de47359760003e910cfbe63db5c99410d6
ToppCell	kidney_cells-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RYR1 MFSD1 FGL2	6.51e-06	194	9	3	6810586080cc893e3270b9c8bee2d95ed78e2893
ToppCell	kidney_cells-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RYR1 MFSD1 FGL2	6.51e-06	194	9	3	abce1e824ce2512741c313a5ec336d12f580b093
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RYR1 MFSD1 FGL2	6.61e-06	195	9	3	312d9625655b38f1a7c2bf8f8bb7b667ebdf9617
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-classical_monocyte\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	MFSD1 FGL2 AGTRAP	6.81e-06	197	9	3	94e2cc7ec531e58b8ed7e5601fdf8c4bbc3582c8
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Macrophages\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RYR1 MFSD1 FGL2	6.81e-06	197	9	3	10190b877bf46ba2163d203df9dd3b498c66e52f
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-classical_monocyte-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	MFSD1 FGL2 AGTRAP	6.81e-06	197	9	3	ffaf2d7b6aa82008bd64a691b48113626343872c
ToppCell	normal-na-Myeloid-classical_monocyte-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	MFSD1 FGL2 AGTRAP	6.92e-06	198	9	3	58aa5041077fe17ca01c5e6da077d8008d5123ab
ToppCell	systemic_lupus_erythematosus-treated-Myeloid-classical_monocyte\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	MFSD1 FGL2 AGTRAP	6.92e-06	198	9	3	1d1c80569f1e307285ba0ebaf5c72e0b5b538864
ToppCell	systemic_lupus_erythematosus-treated-Myeloid\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	MFSD1 FGL2 AGTRAP	6.92e-06	198	9	3	f37578f156e8aed2ce30cfa837ae04dd18de05d0
ToppCell	systemic_lupus_erythematosus-treated-Myeloid-classical_monocyte-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	MFSD1 FGL2 AGTRAP	6.92e-06	198	9	3	c79c1738560d78b63dbed5f2f9621dbc1c2363cb
ToppCell	systemic_lupus_erythematosus-flare-Myeloid\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	MFSD1 FGL2 AGTRAP	6.92e-06	198	9	3	189346c5eb715f3be427bec3b8e067ababb5b475
ToppCell	wk_20-22-Hematologic-Myeloid-SPP1+_Mac\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	RYR1 MFSD1 FGL2	7.02e-06	199	9	3	7c19f1b1f4369edd035ca9cdcf4e653771fc4648
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RYR1 MFSD1 FGL2	7.02e-06	199	9	3	f34c15df58fbdc6c90e30800e26fabbf828ad10b
ToppCell	wk_15-18-Hematologic-Myeloid-SPP1+_Mac\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	RYR1 MFSD1 FGL2	7.02e-06	199	9	3	c7fc2ac1601346aac71e7620a8a440fde8d92dbd
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RYR1 MFSD1 FGL2	7.02e-06	199	9	3	5ceeed92f831d068ff4bb3994f420002338330e7
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RYR1 MFSD1 FGL2	7.13e-06	200	9	3	179afc4bee7a2fd85a3b5dadf32544a63807c164
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial-Glia_progenitor_cell\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	RYR1 FGL2 AGTRAP	7.13e-06	200	9	3	4b937b1d0179d1d0e51931f35720e205d460a07e
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_other\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RYR1 MFSD1 FGL2	7.13e-06	200	9	3	f3dc07a7cc8cf041da8fe610d21af595818cf2d8
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_other\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RYR1 MFSD1 FGL2	7.13e-06	200	9	3	ad52b38df5c71f28829b04cd0e6b97f0f9f7610a
ToppCell	mLN-Dendritic_cell-cDC1\|Dendritic_cell / Region, Cell class and subclass	MFSD1 FGL2	1.74e-04	100	9	2	c560326f6ae5338aecdf11ef8adf04bc8769745c
ToppCell	COVID-19-Heart-Fib_+_CM\|Heart / Disease (COVID-19 only), tissue and cell type	RYR1 MS4A8	1.89e-04	104	9	2	0b60a56a46f1fe3f8224ec6399d009a34a117a21
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	RYR2 FGL2	1.92e-04	105	9	2	8f31edf4183587f5b53941475453c5aa49f10bbd
ToppCell	COVID-19-kidney-Epithelial_Doublet\|kidney / Disease (COVID-19 only), tissue and cell type	RYR1 RYR2	2.68e-04	124	9	2	d6f59ddb9b9df02b5201f23fa5fb78f3fd891ee9
ToppCell	COVID-19-APC-like-Transitioning_MDM\|COVID-19 / group, cell type (main and fine annotations)	RYR1 FGL2	2.77e-04	126	9	2	9f94291b1db020cc0ebf9c8de4e01bd883295672
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-7\|TCGA-Stomach / Sample_Type by Project: Shred V9	RYR2 FAXC	2.81e-04	127	9	2	5e4d110cc6e68cd8fc7a4771a65e6f8cd83e7721
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Conventional_Leiomyosarcoma-2\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	RYR2 FAXC	3.03e-04	132	9	2	a8e7e7f38af095d63e221bcc06a1e5147bb6e467
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	RYR2 FGL2	3.13e-04	134	9	2	3b67c02b430b6d58467f36e606c478d3eea0063f
ToppCell	P03-Hematopoietic\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RYR1 MS4A8	3.46e-04	141	9	2	4a856521520ea73291f4730fe94c5de88c2b6f0c
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_dendritic-myeloid_dendritic_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FAXC FGL2	3.86e-04	149	9	2	71d72a6e7b128ee96161e08f6a0d77be925e73a1
ToppCell	Dendritic_Cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	MFSD1 FGL2	4.12e-04	154	9	2	65013f696da623d37f1e3447a294dfb3c31ae93b
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RYR1 FGL2	4.18e-04	155	9	2	b5d5c38b269e9318970fcce564df1c8ed7a7ccc6
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	RYR1 RYR2	4.40e-04	159	9	2	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	normal_Pleural_Fluid-T/NK_cells-CD4+_Th\|normal_Pleural_Fluid / Location, Cell class and cell subclass	RYR1 AGTRAP	4.40e-04	159	9	2	ebd840ac2b07e62086ee7b5bb01c21804a0fdc7b
ToppCell	E16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FGL2 AGTRAP	4.45e-04	160	9	2	b2d8940ea8c068273b7da1589d3d6ae5110d8209
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MFSD1 FGL2	4.45e-04	160	9	2	709ce00699ca05346287868ea55a1affae0859a8
ToppCell	droplet-Kidney-nan-3m-Lymphocytic-lymphocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 FGL2	4.45e-04	160	9	2	5c28121916a12dbc22ef2421040bdc9148a40b78
ToppCell	E16.5-Immune-Immune_Lymphocytic_T/NK\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FGL2 AGTRAP	4.45e-04	160	9	2	229841be7b984a00a301cd5d88c11226a90d8a88
ToppCell	E16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FGL2 AGTRAP	4.45e-04	160	9	2	99c9ae2041445539fada842e1af01368669bfca0
ToppCell	droplet-Kidney-nan-3m-Lymphocytic-CD45\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 FGL2	4.45e-04	160	9	2	b7093678987575f2f99d648821d31b4a37075aca
ToppCell	E16.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FGL2 AGTRAP	4.45e-04	160	9	2	9caab1bb63c7e66c44783852ee75b16bb40fa594
ToppCell	droplet-Mammary_Gland-nan-21m-Myeloid\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 MS4A8	4.51e-04	161	9	2	3db97af49520dc8cbafb4454d8afd9d588160e89
ToppCell	droplet-Mammary_Gland-nan-21m-Myeloid-macrophage\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 MS4A8	4.51e-04	161	9	2	f1d258c81bcf0f3c52bd20aa58faa9a5fd888168
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	FGL2 AGTRAP	4.51e-04	161	9	2	4362fe0c151f49eae7372b9673bac64d980a8389
ToppCell	droplet-Mammary_Gland-nan-21m-Myeloid-macrophage\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 MS4A8	4.51e-04	161	9	2	787f91f906756ef570c0d02936c3cdfafb3f7454
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|kidney / Disease (COVID-19 only), tissue and cell type	RYR1 RYR2	4.62e-04	163	9	2	19c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCell	droplet-Spleen-nan-3m-Lymphocytic-NK_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGL2 AGTRAP	4.62e-04	163	9	2	2e1c1193c04620cc187b1567dfba025beef1e4e1
ToppCell	droplet-Kidney-KIDNEY-30m-Myeloid-macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGL2 MS4A8	4.68e-04	164	9	2	e19fc6ba049336ab989a3a968bdbefd567971d73
ToppCell	normal_Pleural_Fluid-T/NK_cells-CD4+_Th\|T/NK_cells / Location, Cell class and cell subclass	RYR1 AGTRAP	4.68e-04	164	9	2	334f376350c9cf92611d0f75b2e18a102f4c116a
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	FGL2 AGTRAP	4.68e-04	164	9	2	7077683afee91828ad2b95e0f81c2b27aae0f831
ToppCell	droplet-Kidney-KIDNEY-30m-Myeloid\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FGL2 MS4A8	4.68e-04	164	9	2	d6526551d0b183c3ef027ba3dbfddeac03fd93bb
ToppCell	droplet-Lung-30m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FGL2 MS4A8	4.68e-04	164	9	2	f88871d3b9307112eb7ced4c629f5704326ecae8
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	FGL2 AGTRAP	4.68e-04	164	9	2	10741c7706a37b24aa08a300b27d60d6b8600167
ToppCell	droplet-Thymus-nan-21m-Myeloid-Plasma_cells_and_B_cells\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAXC FGL2	4.73e-04	165	9	2	21a82a975f550080b6674750b06212205cd16742
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Radial_glial-RGCs_early_2\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	MS4A8 AGTRAP	4.73e-04	165	9	2	e460e03992781073cd836a655f15dda3157cea55
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OPN5 MS4A8	4.79e-04	166	9	2	03a47b8687f54955e84df1edcb230db332c4ca8f
ToppCell	droplet-Lung-LUNG-1m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 FGL2	4.79e-04	166	9	2	c215c4aede38d355d35fd26cd7ef2c19efecd0e6
ToppCell	normal_Lymph_Node-Myeloid_cells-CD141+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	FAXC FGL2	4.79e-04	166	9	2	6210a136efb99d70c2026b6454363f1bd2723558
ToppCell	metastatic_Lymph_Node-Myeloid_cells-CD141+_DCs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	RYR2 FGL2	4.79e-04	166	9	2	9f14e3ef19d5903278c040be1c477501237173fa
ToppCell	facs-MAT-Fat-18m-Myeloid-macrophage\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 MS4A8	4.85e-04	167	9	2	c2952d8ba763374c5678b92825c8956fc3e3ecd2
ToppCell	droplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RYR1 FGL2	4.90e-04	168	9	2	d6078e3a79d315d6090906e171a7d67a9206b2c7
ToppCell	Monocytes-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	FGL2 AGTRAP	4.90e-04	168	9	2	9ea3c682ce4e98f1a3303f99b4c63c2cf8863abc
ToppCell	droplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RYR1 FGL2	4.90e-04	168	9	2	99148986aa5628f67d85258c171b254be77a071c
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	RYR1 FGL2	4.96e-04	169	9	2	a0681317867e31319210a23e56660a53f4529efe
ToppCell	droplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RYR1 FGL2	4.96e-04	169	9	2	9c9bb1b32fc6e22359424a262178906c3954415d
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 FGL2	4.96e-04	169	9	2	735655e75511c5c41aca667909e8bb52a0ad7fc6
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	RYR1 AGTRAP	4.96e-04	169	9	2	e3100eb587005e160bd0b7990fa57ec49765133d
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RYR2 FAXC	5.02e-04	170	9	2	cb1ed6bd409ee1cf11be0d5e7cdcffe2ab220d38
ToppCell	facs-Marrow-T-cells-3m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MFSD1 MS4A8	5.02e-04	170	9	2	ff68600b945b3a5437b14e5411b3db800d0ccbe5
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RYR2 FAXC	5.02e-04	170	9	2	da4fb1e186e9bec6bba0b25f2a0e68f9e11c6017
ToppCell	facs-Marrow-T-cells-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MFSD1 MS4A8	5.02e-04	170	9	2	a78d9789c3e7c84a36e1bd380192d7aba4a4d443
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid-Monocytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FGL2 AGTRAP	5.02e-04	170	9	2	1c3c03821c90d41de92fef3278f71093a7fd709c
ToppCell	droplet-Thymus-nan-21m-Myeloid-professional_antigen_presenting_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 FGL2	5.02e-04	170	9	2	29deb285d5a82c0abcc108012ca42f4b4b4d9e19
ToppCell	droplet-Thymus-nan-21m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 FGL2	5.02e-04	170	9	2	dc35d66a9a9fe6cdd7f4ec0fe7efa49d02f2b5b2
ToppCell	droplet-Lung-nan-21m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 FGL2	5.02e-04	170	9	2	71c52fadecc6b4bfe98692b266adaa1406f6d56d
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FGL2 AGTRAP	5.08e-04	171	9	2	686f95892c3909973c66c9a27159a070a068f175
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FGL2 AGTRAP	5.08e-04	171	9	2	f7ba03e7bdb687f93782c936c7b3374cc5b3b77c
ToppCell	droplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RYR1 FGL2	5.08e-04	171	9	2	38a05b5ec8ef8f09a2399994c6b4b9a707918ec1
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FGL2 AGTRAP	5.08e-04	171	9	2	fbf8e9db00573adcada4b25730e191417b7c9999
ToppCell	droplet-Thymus-nan-21m-Myeloid-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 FGL2	5.08e-04	171	9	2	8bed33f61f7d12a1ac4fba33f730d839f5ee7bef
ToppCell	droplet-Kidney-nan-21m-Lymphocytic-lymphocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 FGL2	5.08e-04	171	9	2	0385d5834ae16bbb0c6a68893fec60e4dd1e478d
ToppCell	PND14-Endothelial-Endothelial_lymphatic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FGL2 AGTRAP	5.08e-04	171	9	2	d0ac50071a3854d02113c455fcc940a6ec59bbb9
ToppCell	droplet-Kidney-nan-21m-Lymphocytic-CD45\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 FGL2	5.08e-04	171	9	2	a3e3fe0cbab21abb178c482f5951e576529f7e30
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-conventional_dendritic_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	RYR1 FGL2	5.14e-04	172	9	2	ac20766d1fd43eab8c3ff5e7418a6b38bebf0bd5
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	RYR1 FGL2	5.14e-04	172	9	2	3fd1bc4a8ced0bf9e26ca4ce6d83b5b97bbc2556
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-lymphocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 FGL2	5.14e-04	172	9	2	e680abead2da75e50774da02384eb2729c839c01
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 FGL2	5.14e-04	172	9	2	a5344760b10ecdc0101f78b93b8fc0f8107068c5
ToppCell	droplet-Spleen-nan-21m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 FGL2	5.14e-04	172	9	2	3dc02709c2a6be2155576e5c34e1b0b3ae19b061
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RYR1 OPN5	5.20e-04	173	9	2	d17e50dc400098374af626803dec1241ec566769
ToppCell	5'-Adult-Distal_Rectal-Hematopoietic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MFSD1 FGL2	5.20e-04	173	9	2	b335ca2a247156eba821943b2b9fc9922230b409
Computational	Neighborhood of FOS	MFSD1 FGL2	2.95e-04	41	7	2	GNF2_FOS
Computational	Neighborhood of CD33	MFSD1 FGL2	4.75e-04	52	7	2	GNF2_CD33
Computational	Neighborhood of PECAM1	MFSD1 FGL2	5.51e-04	56	7	2	GNF2_PECAM1
Computational	Ion channels.	RYR1 RYR2	8.60e-04	70	7	2	MODULE_316
Computational	Neighborhood of CARD15	MFSD1 FGL2	8.60e-04	70	7	2	GNF2_CARD15
Computational	Neighborhood of CASP1	MFSD1 FGL2	2.15e-03	111	7	2	GNF2_CASP1
Drug	2-hydroxyheptanoic acid	RYR1 RYR2	4.17e-07	3	9	2	CID002750949
Drug	2-hydroxycarbazole	RYR1 RYR2	4.17e-07	3	9	2	CID000093551
Drug	aminodantrolene	RYR1 RYR2	4.17e-07	3	9	2	CID009570289
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR1 RYR2	4.17e-07	3	9	2	CID005748312
Drug	8N3-cADPR	RYR1 RYR2	4.17e-07	3	9	2	CID000127713
Drug	cis-diammineplatinum(II	RYR1 RYR2	4.17e-07	3	9	2	CID000159790
Drug	AC1L1U7A	RYR1 RYR2	8.33e-07	4	9	2	CID000035682
Drug	PCB74	RYR1 RYR2	8.33e-07	4	9	2	CID000036218
Drug	SC 38249	RYR1 RYR2	8.33e-07	4	9	2	CID000134834
Drug	148504-47-6	RYR1 RYR2	8.33e-07	4	9	2	CID006444275
Drug	A 68930	RYR1 RYR2	1.39e-06	5	9	2	ctd:C065380
Drug	NSC114784	RYR1 RYR2	2.08e-06	6	9	2	CID000419425
Drug	MBED	RYR1 RYR2	2.08e-06	6	9	2	CID000129958
Drug	AC1O528X	RYR1 RYR2	2.08e-06	6	9	2	CID006475857
Drug	chloro-m-cresol	RYR1 RYR2	2.08e-06	6	9	2	CID000012008
Drug	Azumoleno	RYR1 RYR2	2.91e-06	7	9	2	CID000056259
Drug	[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate	RYR1 RYR2	2.91e-06	7	9	2	CID009547999
Drug	Br2BAPTA	RYR1 RYR2	2.91e-06	7	9	2	CID003081001
Drug	N-cyclopentyl-N-cyclobutylformamide	RYR1 RYR2 AGTRAP	3.33e-06	79	9	3	CID005287890
Drug	manidipine	RYR1 RYR2 FGL2	5.80e-06	95	9	3	CID000004008
Drug	PCB 95	RYR1 RYR2	6.24e-06	10	9	2	CID000038012
Drug	PCB 66	RYR1 RYR2	7.63e-06	11	9	2	CID000036185
Drug	R 478	RYR1 RYR2	7.63e-06	11	9	2	CID000084223
Drug	2,3,6,2',3',6'-hexachlorobiphenyl	RYR1 RYR2	7.63e-06	11	9	2	ctd:C010498
Drug	8-amino-cADPR	RYR1 RYR2	7.63e-06	11	9	2	CID003081323
Drug	tectoridin	RYR1 RYR2	7.63e-06	11	9	2	CID005281810
Drug	Ryanodine	RYR1 RYR2	9.15e-06	12	9	2	ctd:D012433
Drug	AC1L1KF5	RYR1 RYR2 FGL2	9.78e-06	113	9	3	CID000005470
Drug	FPL 64176	RYR1 RYR2	1.45e-05	15	9	2	CID000003423
Drug	Gvapspat amide	RYR1 RYR2	1.45e-05	15	9	2	CID000125015
Drug	kazinol B	RYR1 RYR2	1.88e-05	17	9	2	CID000480869
Drug	methylcoumarin	RYR1 RYR2	2.12e-05	18	9	2	CID000007092
Drug	AC1L380G	RYR1 RYR2	2.37e-05	19	9	2	CID000084698
Drug	AC1MW7VF	RYR1 RYR2	2.37e-05	19	9	2	CID000414699
Drug	SK&F 82958	RYR1 RYR2	2.37e-05	19	9	2	ctd:C071262
Drug	Baclofen	RYR1 RYR2	2.63e-05	20	9	2	ctd:D001418
Drug	2,2',3,5',6-pentachlorobiphenyl	RYR1 RYR2	2.63e-05	20	9	2	ctd:C032904
Drug	indo-1/AM	RYR1 RYR2	2.91e-05	21	9	2	CID000123918
Drug	tectorigenin	RYR1 RYR2	2.91e-05	21	9	2	CID005281811
Drug	T0702	RYR1 RYR2	4.15e-05	25	9	2	CID000005908
Drug	dihydropyridine	RYR1 RYR2 AGTRAP	4.85e-05	193	9	3	CID000104822
Drug	Bicuculline	RYR1 RYR2	5.61e-05	29	9	2	ctd:D001640
Drug	2,4-xylidinothiazoline	RYR1 RYR2	6.01e-05	30	9	2	CID000099296
Drug	LOPAC	RYR1 RYR2	6.01e-05	30	9	2	CID000062696
Drug	M-HN	RYR1 RYR2	6.42e-05	31	9	2	CID000015450
Drug	M3/M4	RYR1 RYR2	6.85e-05	32	9	2	CID000486507
Drug	IHC-64	RYR1 RYR2	7.29e-05	33	9	2	CID000162753
Drug	CNS 1145	RYR1 RYR2	7.29e-05	33	9	2	CID000190902
Drug	mag-fura-2	RYR1 RYR2	9.18e-05	37	9	2	CID000123839
Drug	1,2-dichlorohexafluorocyclobutane	RYR1 RYR2	9.18e-05	37	9	2	CID000009643
Drug	4-chloro-m-cresol	RYR1 RYR2	9.18e-05	37	9	2	CID000001732
Drug	AC1L98DX	RYR1 RYR2	9.69e-05	38	9	2	CID000439957
Drug	NAADP	RYR1 RYR2	1.02e-04	39	9	2	CID000123952
Drug	dipyrone	RYR1 RYR2	1.08e-04	40	9	2	CID000003110
Drug	Dantrolene	RYR1 RYR2	1.13e-04	41	9	2	ctd:D003620
Drug	escina	RYR1 RYR2	1.30e-04	44	9	2	CID006433489
Drug	4,4'-dithiodipyridine	RYR1 RYR2	1.36e-04	45	9	2	CID000075846
Drug	U46619	RYR1 RYR2 FGL2	1.54e-04	285	9	3	CID000005618
Drug	ts M	RYR1 RYR2	1.55e-04	48	9	2	CID000428025
Drug	Trp-Trp	RYR1 RYR2	1.62e-04	49	9	2	CID000088656
Drug	AC1L9KQO	RYR1 RYR2	1.62e-04	49	9	2	CID000447335
Drug	etridiazole	RYR1 RYR2	1.68e-04	50	9	2	CID000017432
Drug	Cinildipine	RYR1 RYR2	2.12e-04	56	9	2	CID000002752
Drug	BAPNA	RYR1 FGL2	2.19e-04	57	9	2	CID000013494
Drug	cysteinylglycine	RYR1 RYR2	2.19e-04	57	9	2	CID000065270
Drug	N-benzoyl-L-arginine	FGL2 OPN5	2.27e-04	58	9	2	CID000097369
Drug	Coversyl	FGL2 AGTRAP	2.43e-04	60	9	2	CID000060184
Drug	nilvadipine	RYR1 RYR2	2.43e-04	60	9	2	CID000004494
Drug	IAA-94	RYR1 RYR2	2.51e-04	61	9	2	CID000003667
Drug	Tacrolimus	RYR1 MFSD1 FGL2	2.57e-04	339	9	3	ctd:D016559
Drug	lercanidipine	RYR1 RYR2	2.68e-04	63	9	2	CID000065866
Drug	succinylcholine	RYR1 RYR2	2.76e-04	64	9	2	CID000005314
Drug	fura 2	RYR1 RYR2	2.85e-04	65	9	2	CID000057054
Drug	gallopamil	RYR1 RYR2	3.03e-04	67	9	2	CID000001234
Drug	strontium	RYR1 RYR2	3.12e-04	68	9	2	CID000104798
Drug	tBuBHQ	RYR1 RYR2	3.21e-04	69	9	2	CID000002374
Drug	AC1L2AC7	RYR1 RYR2	3.21e-04	69	9	2	CID000068733
Drug	2-aminopyridine	FGL2 OPN5	3.31e-04	70	9	2	CID000010439
Drug	Digocin	RYR2 AGTRAP	3.31e-04	70	9	2	CID000003062
Drug	flecainide	RYR1 RYR2	3.40e-04	71	9	2	CID000003355
Drug	AC1L1D8L	RYR1 RYR2	3.40e-04	71	9	2	CID000002241
Drug	peroxynitrite	RYR1 RYR2 FGL2	3.40e-04	373	9	3	CID000104806
Drug	CAS 298-57-7	RYR1 RYR2	3.60e-04	73	9	2	CID000002761
Drug	valproate	RYR1 RYR2 FGL2	3.62e-04	381	9	3	CID000003121
Drug	ethosuximide	RYR1 RYR2	3.70e-04	74	9	2	CID000003291
Drug	Benazepril-d5	FGL2 AGTRAP	4.00e-04	77	9	2	CID000002311
Drug	aldosterone	RYR1 RYR2 AGTRAP	4.09e-04	397	9	3	CID000005839
Drug	nisoldipine	RYR1 RYR2	4.11e-04	78	9	2	CID000004499
Drug	Fura-2AM	RYR1 RYR2	4.21e-04	79	9	2	CID000105091
Drug	cADPR	RYR1 RYR2	4.54e-04	82	9	2	CID000123847
Drug	XeC compound	RYR1 RYR2	4.76e-04	84	9	2	CID000005701
Drug	europium	RYR1 RYR2	5.11e-04	87	9	2	CID000023981
Drug	tetracaine	RYR1 RYR2	5.22e-04	88	9	2	CID000005411
Drug	olmesartan	FGL2 AGTRAP	5.59e-04	91	9	2	CID000158781
Drug	adenosine diphosphoribose	RYR1 RYR2	5.71e-04	92	9	2	CID000030243
Drug	AC1MMLID	RYR1 RYR2	5.71e-04	92	9	2	CID000013245
Drug	ruthenium	RYR1 RYR2	5.96e-04	94	9	2	CID000023950
Drug	telmisartan	FGL2 AGTRAP	6.21e-04	96	9	2	CID000065999
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR2	1.93e-07	3	8	2	DOID:8545 (implicated_via_orthology)
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR2	1.93e-07	3	8	2	DOID:3529 (implicated_via_orthology)
Disease	pulmonary hypertension (biomarker_via_orthology)	RYR1 RYR2	2.01e-04	80	8	2	DOID:6432 (biomarker_via_orthology)
Disease	beverage consumption measurement	RYR2 ITSN2	2.16e-04	83	8	2	EFO_0010088
Disease	alcohol use disorder (implicated_via_orthology)	RYR1 RYR2	1.19e-03	195	8	2	DOID:1574 (implicated_via_orthology)
Disease	basophil percentage of leukocytes	RYR1 AGTRAP	1.83e-03	243	8	2	EFO_0007992

Protein segments in the cluster

Peptide	Gene	Start	Entry
WLYGSFQGNFGWFPC	ITSN2	796	Q9NZM3
FGWWAGSEEPFSFYG	FAXC	26	Q5TGI0
FGWIGCRWYGWAGFF	OPN5	101	Q6U736
CRWYGWAGFFFGCGS	OPN5	106	Q6U736
AWYSWPNVVLCFFGG	MFSD1	86	Q9H3U5
ISFYGGFPFWGGLWF	MS4A8	101	Q9BY19
YPSGNCGLYYSSGWW	FGL2	366	Q14314
CWKYYCLPTGWANFG	RYR1	2651	P21817
RCWKYYCLPGGWGNF	RYR2	2616	Q92736
WGCIVFSGSYAWANF	AGTRAP	21	Q6RW13