Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	molecular adaptor activity	NCOR1 BRD8 TCF20 SNAP91 ZMIZ2 ITSN1 ITSN2 TOPBP1 NCOA1 YY1AP1 IRS2 RAD54L2 BCL9 WDR59 EP300	8.67e-07	1356	51	15	GO:0060090
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	NCOR1 BRD8 TCF20 SNAP91 ZMIZ2 TOPBP1 NCOA1 YY1AP1 IRS2 RAD54L2 BCL9 WDR59 EP300	4.82e-06	1160	51	13	GO:0030674
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	SETD1A NCOR1 BRD8 NCOA1 SPOP RXRA EP300 TBP	9.81e-06	417	51	8	GO:0061629
GeneOntologyMolecularFunction	transcription coregulator activity	NCOR1 BRD8 TCF20 ZMIZ2 NCOA1 YY1AP1 RAD54L2 BCL9 EP300	1.10e-05	562	51	9	GO:0003712
GeneOntologyMolecularFunction	beta-catenin binding	SETD1A AMER1 FOXO4 BCL9 EP300	1.36e-05	120	51	5	GO:0008013
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	SETD1A NCOR1 BRD8 NCOA1 FOXO4 SPOP RXRA EP300 TBP	1.46e-05	582	51	9	GO:0140297
GeneOntologyMolecularFunction	transcription factor binding	SETD1A NCOR1 BRD8 PER3 NCOA1 FOXO4 SPOP RXRA EP300 TBP	1.72e-05	753	51	10	GO:0008134
GeneOntologyMolecularFunction	nuclear thyroid hormone receptor binding	NCOR1 BRD8 RXRA	8.88e-05	34	51	3	GO:0046966
GeneOntologyMolecularFunction	nuclear receptor binding	NCOR1 BRD8 NCOA1 RXRA EP300	1.13e-04	187	51	5	GO:0016922
GeneOntologyMolecularFunction	transcription coactivator activity	BRD8 TCF20 ZMIZ2 NCOA1 BCL9 EP300	1.18e-04	303	51	6	GO:0003713
GeneOntologyMolecularFunction	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	SYNJ1 MTM1	3.47e-04	11	51	2	GO:0052629
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	NCOR1 NCOA1 RXRA	3.75e-04	55	51	3	GO:0042974
GeneOntologyMolecularFunction	nuclear receptor coactivator activity	BRD8 ZMIZ2 NCOA1	5.09e-04	61	51	3	GO:0030374
GeneOntologyMolecularFunction	phosphatidylinositol-3-phosphate phosphatase activity	SYNJ1 MTM1	5.71e-04	14	51	2	GO:0004438
GeneOntologyMolecularFunction	phosphatidylinositol monophosphate phosphatase activity	SYNJ1 MTM1	6.57e-04	15	51	2	GO:0052744
GeneOntologyMolecularFunction	phosphatidylinositol-3,5-bisphosphate phosphatase activity	SYNJ1 MTM1	7.50e-04	16	51	2	GO:0106018
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	SETD1A SETBP1	1.18e-03	20	51	2	GO:0042800
GeneOntologyMolecularFunction	peroxisome proliferator activated receptor binding	NCOR1 EP300	1.30e-03	21	51	2	GO:0042975
GeneOntologyMolecularFunction	nuclear retinoid X receptor binding	NCOR1 NCOA1	1.56e-03	23	51	2	GO:0046965
GeneOntologyMolecularFunction	phosphatidylinositol bisphosphate phosphatase activity	SYNJ1 MTM1	2.16e-03	27	51	2	GO:0034593
GeneOntologyMolecularFunction	phosphatidylinositol phosphate phosphatase activity	SYNJ1 MTM1	2.66e-03	30	51	2	GO:0052866
GeneOntologyMolecularFunction	histone modifying activity	SETD1A SETBP1 NCOA1 EP300	2.76e-03	229	51	4	GO:0140993
GeneOntologyMolecularFunction	transcription coregulator binding	PER3 RXRA EP300	5.49e-03	140	51	3	GO:0001221
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	SETD1A SETBP1	5.65e-03	44	51	2	GO:0140938
GeneOntologyBiologicalProcess	regulation of thyroid hormone receptor signaling pathway	NCOR1 NCOA1 RXRA	7.91e-07	8	51	3	GO:0002155
GeneOntologyBiologicalProcess	thyroid hormone receptor signaling pathway	NCOR1 NCOA1 RXRA	1.18e-06	9	51	3	GO:0002154
GeneOntologyBiologicalProcess	clathrin-dependent synaptic vesicle endocytosis	ITSN1 ITSN2	5.99e-06	2	51	2	GO:0150007
GeneOntologyBiologicalProcess	cellular response to Thyroglobulin triiodothyronine	NCOR1 NCOA1	3.59e-05	4	51	2	GO:1904017
GeneOntologyBiologicalProcess	response to Thyroglobulin triiodothyronine	NCOR1 NCOA1	8.93e-05	6	51	2	GO:1904016
GeneOntologyBiologicalProcess	synaptic vesicle endocytosis	SYNJ1 SNAP91 ITSN1 ITSN2	9.31e-05	96	51	4	GO:0048488
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	BRD8 TCF20 VEZF1 ZMIZ2 NCOA1 FOXO4 RAD54L2 BCL9 CCNK RXRA EP300 TBP	1.13e-04	1390	51	12	GO:0045944
GeneOntologyBiologicalProcess	presynaptic endocytosis	SYNJ1 SNAP91 ITSN1 ITSN2	1.18e-04	102	51	4	GO:0140238
GeneOntologyBiologicalProcess	protein-DNA complex organization	SETD1A NCOR1 BRD8 SETBP1 BANP TOPBP1 NCOA1 RAD54L2 EP300 TBP	1.42e-04	999	51	10	GO:0071824
GeneOntologyBiologicalProcess	synaptic vesicle recycling	SYNJ1 SNAP91 ITSN1 ITSN2	1.63e-04	111	51	4	GO:0036465
GeneOntologyBiologicalProcess	synaptic vesicle recycling via endosome	ITSN1 ITSN2	2.66e-04	10	51	2	GO:0036466
GeneOntologyBiologicalProcess	mRNA transcription by RNA polymerase II	NCOA1 RXRA TBP	2.89e-04	52	51	3	GO:0042789
GeneOntologyBiologicalProcess	clathrin-dependent endocytosis	SNAP91 ITSN1 ITSN2	3.06e-04	53	51	3	GO:0072583
GeneOntologyBiologicalProcess	chromatin organization	SETD1A NCOR1 BRD8 SETBP1 BANP TOPBP1 NCOA1 RAD54L2 EP300	3.11e-04	896	51	9	GO:0006325
GeneOntologyBiologicalProcess	mRNA transcription	NCOA1 RXRA TBP	3.79e-04	57	51	3	GO:0009299
GeneOntologyCellularComponent	nuclear body	SETD1A RBM25 AMER1 TCF20 SF3A1 SETBP1 BANP TOPBP1 DACH1 FOXO4 YY1AP1 SPOP RAD54L2	1.34e-07	903	50	13	GO:0016604
GeneOntologyCellularComponent	nuclear speck	SETD1A RBM25 SF3A1 DACH1 FOXO4 SPOP RAD54L2	7.01e-05	431	50	7	GO:0016607
GeneOntologyCellularComponent	chromatin	SETD1A NCOR1 CUX2 BRD8 ZMIZ2 NCOA1 ANKRD17 FOXO4 YY1AP1 RXRA EP300 TBP	1.47e-04	1480	50	12	GO:0000785
GeneOntologyCellularComponent	nuclear protein-containing complex	SETD1A NCOR1 BRD8 SF3A1 TOPBP1 NCOA1 YY1AP1 BCL9 CCNK RXRA TBP	3.34e-04	1377	50	11	GO:0140513
GeneOntologyCellularComponent	transcription regulator complex	NCOR1 DACH1 NCOA1 BCL9 RXRA EP300 TBP	5.10e-04	596	50	7	GO:0005667
GeneOntologyCellularComponent	presynaptic endocytic zone	SNAP91 ITSN1	8.37e-04	18	50	2	GO:0098833
GeneOntologyCellularComponent	clathrin-coated pit	SYNJ1 SNAP91 ITSN1	9.29e-04	80	50	3	GO:0005905
GeneOntologyCellularComponent	clathrin coat of coated pit	SYNJ1 SNAP91	1.14e-03	21	50	2	GO:0030132
GeneOntologyCellularComponent	male germ cell nucleus	TOPBP1 ANKRD17 TBP	1.15e-03	86	50	3	GO:0001673
GeneOntologyCellularComponent	INO80-type complex	BRD8 YY1AP1	2.04e-03	28	50	2	GO:0097346
GeneOntologyCellularComponent	membrane coat	SYNJ1 SNAP91 SEC31B	2.09e-03	106	50	3	GO:0030117
GeneOntologyCellularComponent	coated membrane	SYNJ1 SNAP91 SEC31B	2.09e-03	106	50	3	GO:0048475
GeneOntologyCellularComponent	germ cell nucleus	TOPBP1 ANKRD17 TBP	2.51e-03	113	50	3	GO:0043073
Domain	PH_13	ITSN1 ITSN2	7.31e-06	2	51	2	PF16652
Domain	Nuc_rcpt_coact	NCOA1 EP300	1.09e-04	6	51	2	IPR009110
Domain	EF-hand_4	ITSN1 ITSN2	3.24e-04	10	51	2	PF12763
Domain	EH	ITSN1 ITSN2	3.96e-04	11	51	2	PS50031
Domain	EH	ITSN1 ITSN2	3.96e-04	11	51	2	SM00027
Domain	EH_dom	ITSN1 ITSN2	3.96e-04	11	51	2	IPR000261
Domain	SH3_9	ITSN1 ITSN2 MAP3K21	1.26e-03	78	51	3	PF14604
Domain	PAS	PER3 NCOA1	3.44e-03	32	51	2	SM00091
Domain	PH	SH3BP2 ITSN1 ITSN2 IRS2	3.50e-03	229	51	4	PF00169
Domain	PAS	PER3 NCOA1	3.88e-03	34	51	2	IPR000014
Domain	PAS	PER3 NCOA1	3.88e-03	34	51	2	PS50112
Domain	-	SH3BP2 ITSN1 MTM1 ITSN2 IRS2	4.18e-03	391	51	5	2.30.29.30
Domain	BROMODOMAIN_1	BRD8 EP300	4.58e-03	37	51	2	PS00633
Domain	Bromodomain	BRD8 EP300	4.83e-03	38	51	2	PF00439
Domain	BROMODOMAIN_2	BRD8 EP300	5.60e-03	41	51	2	PS50014
Domain	BROMO	BRD8 EP300	5.87e-03	42	51	2	SM00297
Domain	Bromodomain	BRD8 EP300	5.87e-03	42	51	2	IPR001487
Domain	-	BRD8 EP300	5.87e-03	42	51	2	1.20.920.10
Domain	PH_dom-like	SH3BP2 ITSN1 MTM1 ITSN2 IRS2	5.99e-03	426	51	5	IPR011993
Domain	PH	SH3BP2 ITSN1 ITSN2 IRS2	6.93e-03	278	51	4	SM00233
Domain	PH_DOMAIN	SH3BP2 ITSN1 ITSN2 IRS2	7.02e-03	279	51	4	PS50003
Domain	PH_domain	SH3BP2 ITSN1 ITSN2 IRS2	7.11e-03	280	51	4	IPR001849
Pathway	BIOCARTA_VDR_PATHWAY	NCOR1 NCOA1 RXRA EP300	5.67e-07	24	40	4	M13404
Pathway	BIOCARTA_RARRXR_PATHWAY	NCOA1 RXRA TBP	7.35e-07	7	40	3	M6907
Pathway	BIOCARTA_PPARG_PATHWAY	NCOA1 RXRA EP300	1.17e-06	8	40	3	M22058
Pathway	REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_CONTROL_BILE_ACID_HOMEOSTASIS	NCOR1 NCOA1 RXRA	1.76e-06	9	40	3	M29809
Pathway	REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX	NCOR1 NCOA1 RXRA EP300	3.43e-06	37	40	4	M29790
Pathway	REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING	NCOA1 RXRA EP300	5.94e-06	13	40	3	MM15622
Pathway	REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING	NCOR1 NCOA1 RXRA EP300	9.08e-06	47	40	4	M29777
Pathway	REACTOME_HEME_SIGNALING	NCOR1 NCOA1 RXRA EP300	1.07e-05	49	40	4	M41832
Pathway	BIOCARTA_PPARA_PATHWAY	NCOR1 NCOA1 RXRA EP300	1.36e-05	52	40	4	M2404
Pathway	PID_AR_TF_PATHWAY	ZMIZ2 NCOA1 RXRA EP300	1.47e-05	53	40	4	M151
Pathway	REACTOME_RORA_ACTIVATES_GENE_EXPRESSION	NCOA1 RXRA EP300	1.68e-05	18	40	3	M26942
Pathway	BIOCARTA_VDR_PATHWAY	NCOR1 RXRA EP300	3.14e-05	22	40	3	MM1370
Pathway	REACTOME_CIRCADIAN_CLOCK	NCOR1 NCOA1 RXRA EP300	4.45e-05	70	40	4	M938
Pathway	PID_RETINOIC_ACID_PATHWAY	NCOA1 RXRA EP300	8.15e-05	30	40	3	M207
Pathway	PID_SMAD2_3NUCLEAR_PATHWAY	NCOR1 NCOA1 FOXO4 EP300	8.29e-05	82	40	4	M2
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION	NCOR1 NCOA1 RXRA EP300	9.10e-05	84	40	4	M1008
Pathway	WP_PRION_DISEASE_PATHWAY	RXRA EP300 TBP	9.92e-05	32	40	3	M39636
Pathway	BIOCARTA_RARRXR_PATHWAY	RXRA TBP	1.17e-04	6	40	2	MM1447
Pathway	REACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_CONTROL_BILE_ACID_HOMEOSTASIS	NCOA1 RXRA	1.17e-04	6	40	2	MM15663
Pathway	BIOCARTA_PPARG_PATHWAY	RXRA EP300	1.63e-04	7	40	2	MM1573
Pathway	REACTOME_ADIPOGENESIS	NCOR1 NCOA1 RXRA EP300	2.58e-04	110	40	4	M48259
Pathway	REACTOME_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS	NCOR1 AMER1 NCOA1 RXRA EP300	3.01e-04	210	40	5	M41836
Pathway	WP_ENERGY_METABOLISM	NCOA1 RXRA EP300	3.35e-04	48	40	3	M39590
Pathway	PID_HES_HEY_PATHWAY	NCOR1 NCOA1 EP300	3.35e-04	48	40	3	M288
Pathway	REACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA	NCOR1 NCOA1 RXRA EP300	3.38e-04	118	40	4	M27316
Pathway	REACTOME_REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACETYLATION	FOXO4 EP300	3.48e-04	10	40	2	M27945
Pathway	REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER	NCOR1 CCNK EP300	4.01e-04	51	40	3	M665
Pathway	BIOCARTA_CARM1_PATHWAY	RXRA EP300	4.25e-04	11	40	2	MM1521
Pathway	REACTOME_TRANSCRIPTIONAL_ACTIVATION_OF_MITOCHONDRIAL_BIOGENESIS	NCOR1 NCOA1 RXRA	5.01e-04	55	40	3	M27145
Pathway	WP_ADIPOGENESIS	NCOR1 NCOA1 IRS2 RXRA	5.02e-04	131	40	4	M39505
Pathway	BIOCARTA_CARM1_PATHWAY	RXRA EP300	5.09e-04	12	40	2	M7968
Pathway	WP_ADIPOGENESIS_GENES	NCOR1 NCOA1 IRS2 RXRA	5.95e-04	137	40	4	MM15970
Pathway	REACTOME_CYTOPROTECTION_BY_HMOX1	NCOR1 NCOA1 RXRA	6.47e-04	60	40	3	M41830
Pathway	REACTOME_CLATHRIN_MEDIATED_ENDOCYTOSIS	SYNJ1 SNAP91 ITSN1 ITSN2	6.81e-04	142	40	4	MM15499
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL	NCOA1 RXRA	6.99e-04	14	40	2	M27074
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL	NCOA1 RXRA	6.99e-04	14	40	2	MM14748
Pathway	REACTOME_CLATHRIN_MEDIATED_ENDOCYTOSIS	SYNJ1 SNAP91 ITSN1 ITSN2	7.36e-04	145	40	4	M27753
Pathway	REACTOME_ESTROGEN_DEPENDENT_GENE_EXPRESSION	NCOA1 EP300 TBP	7.47e-04	63	40	3	MM15613
Pathway	PID_ERA_GENOMIC_PATHWAY	NCOR1 NCOA1 EP300	7.82e-04	64	40	3	M200
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_DEATH_GENES	FOXO4 EP300	9.19e-04	16	40	2	M27940
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	SETD1A NCOR1 BRD8 NCOA1 EP300	9.76e-04	272	40	5	M29619
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY	BANP TOPBP1 EP300 TBP	9.90e-04	157	40	4	MM15226
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY	BANP TOPBP1 EP300 TBP	1.06e-03	160	40	4	M27498
Pathway	REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS	NCOR1 CCNK RXRA EP300	1.09e-03	161	40	4	M27871
Pathway	REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS	NCOA1 RXRA	1.17e-03	18	40	2	M4862
Pathway	REACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA	NCOA1 RXRA	1.17e-03	18	40	2	MM15034
Pathway	REACTOME_SIGNALING_BY_NOTCH1	DTX2 EP300	1.17e-03	18	40	2	MM14775
Pathway	REACTOME_SIGNALING_BY_NOTCH1	NCOR1 DTX2 EP300	1.19e-03	74	40	3	M616
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	SETD1A BANP TOPBP1 FOXO4 CCNK RXRA EP300 TBP	1.22e-03	768	40	8	MM14851
Pathway	REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS	NCOA1 RXRA	1.30e-03	19	40	2	MM14612
Pathway	WP_FARNESOID_X_RECEPTOR_PATHWAY	IRS2 RXRA	1.30e-03	19	40	2	M39411
Pathway	WP_ESTROGEN_SIGNALING	NCOR1 EP300 TBP	1.34e-03	77	40	3	MM15934
Pathway	REACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS	NCOR1 NCOA1 RXRA EP300 TBP	1.42e-03	296	40	5	M27869
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_TP53	BANP TOPBP1 CCNK EP300 TBP	1.60e-03	304	40	5	MM14960
Pathway	PID_REG_GR_PATHWAY	NCOA1 EP300 TBP	1.60e-03	82	40	3	M115
Pathway	WP_TRANSCRIPTION_FACTOR_REGULATION_IN_ADIPOGENESIS	IRS2 RXRA	1.75e-03	22	40	2	M39414
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION	FOXO4 EP300	1.75e-03	22	40	2	MM15656
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL	NCOA1 RXRA	1.91e-03	23	40	2	M1926
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL	NCOA1 RXRA	1.91e-03	23	40	2	MM14741
Pathway	REACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS	NCOA1 RXRA EP300 TBP	2.04e-03	191	40	4	MM15586
Pathway	WP_ANDROGEN_RECEPTOR_SIGNALING	NCOR1 NCOA1 EP300	2.16e-03	91	40	3	M39700
Pathway	REACTOME_ENDOGENOUS_STEROLS	NCOA1 RXRA	2.26e-03	25	40	2	M11184
Pathway	REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX	NCOR1 CCNK EP300	2.37e-03	94	40	3	M1041
Pathway	BIOCARTA_CARM_ER_PATHWAY	EP300 TBP	2.44e-03	26	40	2	M2499
Pathway	PID_RXR_VDR_PATHWAY	NCOA1 RXRA	2.44e-03	26	40	2	M162
Pathway	PID_HDAC_CLASSIII_PATHWAY	FOXO4 EP300	2.44e-03	26	40	2	M32
Pathway	REACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX	BCL9 EP300	2.44e-03	26	40	2	MM14793
Pathway	REACTOME_MITOCHONDRIAL_BIOGENESIS	NCOR1 NCOA1 RXRA	2.52e-03	96	40	3	M26973
Pathway	REACTOME_ENDOGENOUS_STEROLS	NCOA1 RXRA	2.63e-03	27	40	2	MM14844
Pathway	REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_GENE_EXPRESSION	NCOA1 RXRA	2.63e-03	27	40	2	M26943
Pathway	WP_IL6_SIGNALING_PATHWAY	NCOA1 FOXO4 EP300	2.83e-03	100	40	3	MM15826
Pathway	REACTOME_TGFBR3_EXPRESSION	RXRA EP300	2.83e-03	28	40	2	M48253
Pathway	REACTOME_CARGO_RECOGNITION_FOR_CLATHRIN_MEDIATED_ENDOCYTOSIS	SNAP91 ITSN1 ITSN2	2.99e-03	102	40	3	MM15498
Pathway	PID_CDC42_REG_PATHWAY	ITSN1 ITSN2	3.25e-03	30	40	2	M83
Pathway	REACTOME_POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION	EP300 TBP	3.25e-03	30	40	2	MM15173
Pathway	REACTOME_CARGO_RECOGNITION_FOR_CLATHRIN_MEDIATED_ENDOCYTOSIS	SNAP91 ITSN1 ITSN2	3.25e-03	105	40	3	M27752
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_TP53	BANP TOPBP1 CCNK EP300 TBP	3.33e-03	360	40	5	M27267
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_OF_BROWN_AND_BEIGE_ADIPOCYTE_DIFFERENTIATION	NCOA1 RXRA	3.47e-03	31	40	2	M48258
Pathway	WP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY	NCOA1 RXRA	3.47e-03	31	40	2	M39476
Pathway	WP_PREGNANE_X_RECEPTOR_PATHWAY	NCOA1 RXRA	3.69e-03	32	40	2	M39567
Pathway	WP_WNT_SIGNALING_PATHWAY	BCL9 EP300 TBP	3.70e-03	110	40	3	MM15977
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS	NCOA1 RXRA	3.92e-03	33	40	2	M5967
Pathway	REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS	NCOA1 RXRA	3.92e-03	33	40	2	MM14737
Pathway	WP_OVARIAN_INFERTILITY	NCOR1 TBP	4.40e-03	35	40	2	MM15948
Pathway	REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION	CCNK EP300	4.65e-03	36	40	2	M633
Pathway	REACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS	NCOR1 RXRA EP300	4.95e-03	122	40	3	M29689
Pathway	REACTOME_SIGNALING_BY_NOTCH	DTX2 EP300	5.44e-03	39	40	2	MM14604
Pathway	WP_OVARIAN_INFERTILITY	NCOR1 TBP	5.44e-03	39	40	2	M39458
Pathway	PID_EPHB_FWD_PATHWAY	SYNJ1 ITSN1	5.72e-03	40	40	2	M62
Pathway	REACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS	NCOA1 EP300	5.72e-03	40	40	2	MM15000
Pubmed	Human transcription factor protein interaction networks.	SETD1A NCOR1 RBM25 BRD8 TCF20 VEZF1 ZMIZ2 BANP DACH1 NCOA1 ANKRD17 YY1AP1 SPOP RAD54L2 BCL9 RXRA EP300 PRRC2B TBP	1.28e-13	1429	53	19	35140242
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	NCOR1 TCF20 ITSN2 NCOA1 MUC16 ANKRD17 IRS2 BCL9 SEC31B EP300 RYR1 PRRC2B	1.76e-10	638	53	12	31182584
Pubmed	Natural helix 9 mutants of PPARγ differently affect its transcriptional activity.	NCOR1 NCOA1 RXRA EP300	1.00e-09	10	53	4	30595551
Pubmed	Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation.	NCOA1 RXRA EP300 TBP	1.57e-09	11	53	4	10454579
Pubmed	Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes.	NCOR1 NCOA1 RXRA EP300	1.57e-09	11	53	4	15681609
Pubmed	Interaction network of human early embryonic transcription factors.	SETD1A NCOR1 TCF20 ZMIZ2 NCOA1 RAD54L2 BCL9 EP300 PRRC2B	2.94e-09	351	53	9	38297188
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	ZMIZ2 NCOA1 DTX2 BCL9 CCNK EP300 PRRC2B	3.45e-09	152	53	7	38360978
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	ZC3H10 NCOR1 TCF20 VEZF1 SF3A1 ZMIZ2 DACH1 NCOA1 RAD54L2 BCL9 CCNK EP300 PRRC2B	7.94e-09	1103	53	13	34189442
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SETD1A NCOR1 SYNJ1 ZMIZ2 BANP ZFYVE26 IRS2 DTX2 BCL9 WDR59 EP300 RYR1 PRRC2B	8.11e-09	1105	53	13	35748872
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SETD1A NCOR1 RBM25 BRD8 TCF20 SYNJ1 DACH1 CCNK EP300 PRRC2B	9.39e-09	549	53	10	38280479
Pubmed	p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers.	BRD8 NCOA1 RXRA	1.34e-08	4	53	3	10517671
Pubmed	Agonist-triggered modulation of the activated and silent state of the vitamin D(3) receptor by interaction with co-repressors and co-activators.	NCOR1 NCOA1 RXRA	1.34e-08	4	53	3	11124027
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	NCOR1 RBM25 BRD8 TCF20 SF3A1 ITSN1 ANKRD17 YY1AP1 IRS2 BCL9 CCNK	2.01e-08	774	53	11	15302935
Pubmed	T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.	NCOR1 NCOA1 RXRA EP300	2.29e-08	20	53	4	11877444
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZC3H10 NCOR1 CUX2 BRD8 TCF20 PER3 VEZF1 ZMIZ2 NCOA1 RXRA TBP	3.12e-08	808	53	11	20412781
Pubmed	Ski-interacting protein, a bifunctional nuclear receptor coregulator that interacts with N-CoR/SMRT and p300.	NCOR1 NCOA1 EP300	3.33e-08	5	53	3	14985122
Pubmed	The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis.	NCOR1 NCOA1 EP300	6.66e-08	6	53	3	17468099
Pubmed	Temporal/spatial expression of nuclear receptor coactivators in the mouse lung.	NCOA1 RXRA EP300	6.66e-08	6	53	3	11076796
Pubmed	The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators.	NCOR1 NCOA1 RXRA	6.66e-08	6	53	3	9878542
Pubmed	DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells.	NCOA1 FOXO4 EP300	6.66e-08	6	53	3	10973497
Pubmed	Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor.	NCOR1 NCOA1 RXRA	1.16e-07	7	53	3	16606617
Pubmed	EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis?	SYNJ1 ITSN1 ITSN2	1.16e-07	7	53	3	10373452
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	NCOR1 BRD8 TCF20 NCOA1 BCL9 CCNK PRRC2B	1.70e-07	268	53	7	33640491
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	NCOR1 TCF20 DACH1 BCL9 EP300	1.80e-07	83	53	5	28794006
Pubmed	The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors.	NCOR1 NCOA1 RXRA	1.86e-07	8	53	3	19786558
Pubmed	Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid X receptor heterodimers with ligands, coactivators, and corepressors.	NCOR1 NCOA1 RXRA	1.86e-07	8	53	3	9121466
Pubmed	Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism.	RXRA EP300 TBP	1.86e-07	8	53	3	12040021
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	NCOR1 SYNJ1 ITSN1 BANP TOPBP1 YY1AP1 RAD54L2 RUFY3 PRRC2B	2.43e-07	588	53	9	38580884
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	SETD1A NCOR1 CUX2 ZMIZ2 ITSN1 SETBP1 RAD54L2 BCL9	2.79e-07	430	53	8	35044719
Pubmed	NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes.	RXRA EP300 TBP	3.98e-07	10	53	3	15601870
Pubmed	Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells.	NCOR1 NCOA1 EP300	3.98e-07	10	53	3	12738788
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	NCOR1 BRD8 SF3A1 BANP DACH1 ANKRD17 FOXO4 RXRA EP300 TBP	5.86e-07	857	53	10	25609649
Pubmed	MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation.	NCOA1 RXRA EP300	1.20e-06	14	53	3	17641689
Pubmed	E protein silencing by the leukemogenic AML1-ETO fusion protein.	NCOR1 EP300 TBP	1.20e-06	14	53	3	15333839
Pubmed	Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.	RXRA EP300 TBP	1.50e-06	15	53	3	9267036
Pubmed	A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.	NCOA1 RXRA TBP	1.50e-06	15	53	3	10567404
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	NCOR1 RBM25 BRD8 TCF20 VEZF1 SNAP91 SF3A1 TOPBP1 DACH1 CCNK	1.54e-06	954	53	10	36373674
Pubmed	Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.	NCOR1 NCOA1 EP300	2.24e-06	17	53	3	19183483
Pubmed	Agonist ligands mediate the transcriptional response of nuclear receptor heterodimers through distinct stoichiometric assemblies with coactivators.	NCOA1 RXRA	2.28e-06	2	53	2	25053412
Pubmed	Intersectin deficiency impairs cortico-striatal neurotransmission and causes obsessive-compulsive behaviors in mice.	ITSN1 ITSN2	2.28e-06	2	53	2	37603735
Pubmed	Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain.	ITSN1 ITSN2	2.28e-06	2	53	2	31031201
Pubmed	Intersectin associates with synapsin and regulates its nanoscale localization and function.	ITSN1 ITSN2	2.28e-06	2	53	2	29078407
Pubmed	SPOP downregulation promotes bladder cancer progression based on cancer cell-macrophage crosstalk via STAT3/CCL2/IL-6 axis and is regulated by VEZF1.	VEZF1 SPOP	2.28e-06	2	53	2	39479456
Pubmed	Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.	ITSN1 ITSN2	2.28e-06	2	53	2	23936226
Pubmed	Vertebrate intersectin1 is repurposed to facilitate cortical midline connectivity and higher order cognition.	ITSN1 ITSN2	2.28e-06	2	53	2	23447614
Pubmed	Structural and functional characterization of a novel type of ligand-independent RXR-USP receptor.	NCOA1 RXRA	2.28e-06	2	53	2	17673910
Pubmed	The human intersectin genes and their spliced variants are differentially expressed.	ITSN1 ITSN2	2.28e-06	2	53	2	11690630
Pubmed	Interactions between the retinoid X receptor and a conserved region of the TATA-binding protein mediate hormone-dependent transactivation.	RXRA TBP	2.28e-06	2	53	2	7667283
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	TCF20 SYNJ1 VEZF1 ZMIZ2 NCOA1 YY1AP1 EP300	2.39e-06	398	53	7	35016035
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	ZC3H10 NCOR1 YY1AP1 DTX2 RAD54L2 CCNK PRRC2B TBP	3.70e-06	608	53	8	16713569
Pubmed	Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor.	NCOR1 NCOA1 EP300	4.36e-06	21	53	3	19596656
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	MIIP AMER1 TCF20 SYNJ1 ANKRD17 FOXO4 IRS2 MAP3K21 WDR59	5.60e-06	861	53	9	36931259
Pubmed	Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells.	NCOR1 NCOA1 RXRA	5.79e-06	23	53	3	19737349
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	NCOR1 TCF20 ANKRD17 DTX2 BCL9 EP300 PRRC2B	5.91e-06	457	53	7	32344865
Pubmed	Cellular, biochemical and molecular changes in muscles from patients with X-linked myotubular myopathy due to MTM1 mutations.	MTM1 RYR1	6.83e-06	3	53	2	28007904
Pubmed	Behavioral analysis in mice deficient for GAREM2 (Grb2-associated regulator of Erk/MAPK subtype2) that is a subtype of highly expressing in the brain.	ITSN1 ITSN2	6.83e-06	3	53	2	31718706
Pubmed	Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors.	NCOR1 NCOA1	6.83e-06	3	53	2	24550004
Pubmed	Nuclear receptor coregulators differentially modulate induction and glucocorticoid receptor-mediated repression of the corticotropin-releasing hormone gene.	NCOR1 NCOA1	6.83e-06	3	53	2	18006628
Pubmed	The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.	NCOA1 EP300	6.83e-06	3	53	2	8855229
Pubmed	Molecular determinants of the interactions between SRC-1 and LXR/RXR heterodimers.	NCOA1 RXRA	6.83e-06	3	53	2	20682316
Pubmed	Analysis of the functional role of steroid receptor coactivator-1 in ligand-induced transactivation by thyroid hormone receptor.	NCOA1 RXRA	6.83e-06	3	53	2	9171239
Pubmed	p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha.	NCOA1 EP300	6.83e-06	3	53	2	9407140
Pubmed	Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis.	ITSN1 ITSN2	6.83e-06	3	53	2	10922467
Pubmed	Mediator and p300/CBP-steroid receptor coactivator complexes have distinct roles, but function synergistically, during estrogen receptor alpha-dependent transcription with chromatin templates.	NCOA1 EP300	6.83e-06	3	53	2	12482985
Pubmed	Acute promyelocytic leukemia cell line AP-1060 established as a cytokine-dependent culture from a patient clinically resistant to all-trans retinoic acid and arsenic trioxide.	NCOR1 RXRA	6.83e-06	3	53	2	15116119
Pubmed	Co-activator SRC-1 is dispensable for transcriptional control by STAT3.	NCOA1 EP300	6.83e-06	3	53	2	19203349
Pubmed	The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription.	TCF20 TOPBP1	6.83e-06	3	53	2	17913746
Pubmed	Expression of ERβ and its co-regulators p300 and NCoR in human transitional cell bladder cancer.	NCOR1 EP300	6.83e-06	3	53	2	21525722
Pubmed	Ligand binding and heterodimerization with retinoid X receptor α (RXRα) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding.	NCOA1 RXRA	6.83e-06	3	53	2	30275017
Pubmed	Structural and functional analysis of the human nuclear xenobiotic receptor PXR in complex with RXRα.	NCOA1 RXRA	6.83e-06	3	53	2	23602807
Pubmed	Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.	NCOA1 EP300	6.83e-06	3	53	2	11773079
Pubmed	Dissociation of steroid receptor coactivator 1 and nuclear receptor corepressor recruitment to the human glucocorticoid receptor by modification of the ligand-receptor interface: the role of tyrosine 735.	NCOR1 NCOA1	6.83e-06	3	53	2	12569182
Pubmed	The unique tryptophan residue of the vitamin D receptor is critical for ligand binding and transcriptional activation.	NCOA1 RXRA	6.83e-06	3	53	2	11149488
Pubmed	In vivo activation of PPAR target genes by RXR homodimers.	NCOA1 RXRA	6.83e-06	3	53	2	15103326
Pubmed	p300 is involved in formation of the TBP-TFIIA-containing basal transcription complex, TAC.	EP300 TBP	6.83e-06	3	53	2	12941701
Pubmed	Regulation of ligand-induced heterodimerization and coactivator interaction by the activation function-2 domain of the vitamin D receptor.	NCOA1 RXRA	6.83e-06	3	53	2	11075811
Pubmed	1,25-Dihydroxyvitamin D3 stimulates cyclic vitamin D receptor/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblasts.	RXRA EP300	6.83e-06	3	53	2	15647825
Pubmed	Defective release of corepressor by hinge mutants of the thyroid hormone receptor found in patients with resistance to thyroid hormone.	NCOR1 NCOA1	6.83e-06	3	53	2	9804773
Pubmed	Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission.	SNAP91 ITSN1	6.83e-06	3	53	2	31940485
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	NCOR1 TCF20 DTX2 RAD54L2 BCL9	8.24e-06	180	53	5	35198878
Pubmed	A human MAP kinase interactome.	TCF20 ITSN1 ITSN2 ANKRD17 YY1AP1 MAP3K21 EP300	8.82e-06	486	53	7	20936779
Pubmed	Characterization of monoclonal antibodies raised against p300: both p300 and CBP are present in intracellular TBP complexes.	EP300 TBP	1.36e-05	4	53	2	8995708
Pubmed	Human TAF(II28) promotes transcriptional stimulation by activation function 2 of the retinoid X receptors.	RXRA TBP	1.36e-05	4	53	2	8670810
Pubmed	Vitamin D-dependent recruitment of corepressors to vitamin D/retinoid X receptor heterodimers.	NCOR1 RXRA	1.36e-05	4	53	2	18362166
Pubmed	A selective peroxisome proliferator-activated receptor-gamma modulator, telmisartan, binds to the receptor in a different fashion from thiazolidinediones.	NCOR1 RXRA	1.36e-05	4	53	2	19147680
Pubmed	Lack of myotubularin (MTM1) leads to muscle hypotrophy through unbalanced regulation of the autophagy and ubiquitin-proteasome pathways.	MTM1 RYR1	1.36e-05	4	53	2	23695157
Pubmed	p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer.	NCOA1 RXRA	1.36e-05	4	53	2	27728806
Pubmed	Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator.	NCOA1 TBP	1.36e-05	4	53	2	8754792
Pubmed	Cleaved high molecular weight kininogen stimulates JNK/FOXO4/MnSOD pathway for induction of endothelial progenitor cell senescence.	FOXO4 KNG1	1.36e-05	4	53	2	24984152
Pubmed	Cyclic changes in the expression of steroid receptor coactivators and corepressors in the normal human endometrium.	NCOA1 EP300	1.36e-05	4	53	2	12574227
Pubmed	Direct association between the CREB-binding protein (CBP) and nuclear receptor corepressor (N-CoR).	NCOR1 EP300	1.36e-05	4	53	2	17073437
Pubmed	Ligand-dependent degradation of retinoid X receptors does not require transcriptional activity or coactivator interactions.	NCOA1 RXRA	1.36e-05	4	53	2	11438648
Pubmed	Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators.	NCOA1 EP300	1.36e-05	4	53	2	12208951
Pubmed	The oncoprotein Tax binds the SRC-1-interacting domain of CBP/p300 to mediate transcriptional activation.	NCOA1 EP300	1.36e-05	4	53	2	11463834
Pubmed	Three amino acids specify coactivator choice by retinoid X receptors.	NCOA1 RXRA	1.36e-05	4	53	2	10935544
Pubmed	The retinoid X receptor binding to the thyroid hormone receptor: relationship with cofactor binding and transcriptional activity.	NCOR1 RXRA	1.36e-05	4	53	2	19211732
Pubmed	Mammalian verprolin CR16 acts as a modulator of ITSN scaffold proteins association with actin.	ITSN1 ITSN2	1.36e-05	4	53	2	28161632
Pubmed	Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells.	NCOR1 NCOA1	1.36e-05	4	53	2	15256534
Pubmed	Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity.	RXRA EP300	1.36e-05	4	53	2	26855179
Pubmed	Acetylation and alternative splicing regulate ZNF76-mediated transcription.	EP300 TBP	1.36e-05	4	53	2	16337145
Interaction	FEV interactions	SETD1A NCOR1 TCF20 VEZF1 DACH1 YY1AP1 RAD54L2 BCL9 EP300 PRRC2B	7.68e-11	203	51	10	int:FEV
Interaction	NR3C1 interactions	NCOR1 TCF20 SF3A1 ITSN2 NCOA1 MUC16 ANKRD17 IRS2 RAD54L2 BCL9 SEC31B EP300 RYR1 PRRC2B TBP	1.02e-08	974	51	15	int:NR3C1
Interaction	ALG13 interactions	ZC3H10 NCOR1 RBM25 TCF20 BCL9 CCNK EP300 PRRC2B	1.81e-08	183	51	8	int:ALG13
Interaction	UBE2I interactions	ZC3H10 NCOR1 RBM25 VEZF1 SETBP1 BANP DACH1 SPOP RAD54L2 RXRA EP300 TBP	6.14e-08	654	51	12	int:UBE2I
Interaction	RXRA interactions	NCOR1 BRD8 NCOA1 RAD54L2 RXRA EP300 TBP	2.19e-07	169	51	7	int:RXRA
Interaction	CRX interactions	ZC3H10 TCF20 ZMIZ2 BANP NCOA1 BCL9 EP300 PRRC2B	2.27e-07	254	51	8	int:CRX
Interaction	EGR2 interactions	NCOR1 ZMIZ2 NCOA1 RAD54L2 BCL9 EP300 PRRC2B	2.37e-07	171	51	7	int:EGR2
Interaction	NFYA interactions	ZC3H10 VEZF1 BANP TOPBP1 EP300 TBP	2.58e-07	105	51	6	int:NFYA
Interaction	TLE3 interactions	NCOR1 BRD8 TCF20 VEZF1 ZMIZ2 NCOA1 RAD54L2 BCL9 EP300	3.79e-07	376	51	9	int:TLE3
Interaction	HNF4A interactions	SETD1A NCOR1 BRD8 DACH1 NCOA1 RAD54L2 EP300 TBP	4.16e-07	275	51	8	int:HNF4A
Interaction	KLF15 interactions	NCOR1 BRD8 VEZF1 BANP NCOA1 BCL9 EP300 PRRC2B	6.22e-07	290	51	8	int:KLF15
Interaction	AR interactions	NCOR1 RBM25 BRD8 TCF20 ZMIZ2 NCOA1 SPOP RAD54L2 BCL9 CCNK EP300 PRRC2B TBP	7.66e-07	992	51	13	int:AR
Interaction	SP7 interactions	NCOR1 RBM25 TCF20 ZMIZ2 NCOA1 BCL9 EP300 PRRC2B	8.86e-07	304	51	8	int:SP7
Interaction	NR1H4 interactions	NCOR1 NCOA1 RXRA EP300	1.24e-06	32	51	4	int:NR1H4
Interaction	ERG interactions	NCOR1 TCF20 SPOP RAD54L2 BCL9 EP300 PRRC2B	1.42e-06	223	51	7	int:ERG
Interaction	NCOA3 interactions	NCOR1 NCOA1 SPOP DTX2 RXRA EP300 TBP	1.46e-06	224	51	7	int:NCOA3
Interaction	CEBPA interactions	ZC3H10 NCOR1 TCF20 VEZF1 SF3A1 ZMIZ2 DACH1 NCOA1 YY1AP1 RAD54L2 BCL9 CCNK EP300 PRRC2B	1.64e-06	1245	51	14	int:CEBPA
Interaction	KRTAP8-1 interactions	ZC3H10 VEZF1 BANP DTX2 CCNK	1.66e-06	79	51	5	int:KRTAP8-1
Interaction	HOXB2 interactions	ZMIZ2 NCOA1 DTX2 EP300	2.02e-06	36	51	4	int:HOXB2
Interaction	NUP50 interactions	SETD1A NCOR1 TCF20 ITSN2 DACH1 SPOP DTX2 CCNK	2.09e-06	341	51	8	int:NUP50
Interaction	EYA4 interactions	ZMIZ2 NCOA1 DTX2 BCL9 CCNK EP300 PRRC2B	2.50e-06	243	51	7	int:EYA4
Interaction	PAX6 interactions	NCOR1 SYNJ1 BANP DACH1 BCL9 EP300 PRRC2B TBP	3.53e-06	366	51	8	int:PAX6
Interaction	CBX3 interactions	SETD1A NCOR1 AMER1 TCF20 VEZF1 TOPBP1 DACH1 RAD54L2 EP300 PRRC2B	4.17e-06	646	51	10	int:CBX3
Interaction	RARB interactions	NCOA1 RXRA EP300 TBP	5.49e-06	46	51	4	int:RARB
Interaction	PRR20E interactions	ZC3H10 VEZF1 BANP YY1AP1 CCNK	5.60e-06	101	51	5	int:PRR20E
Interaction	FHL2 interactions	SETD1A NCOR1 AMER1 BANP ANKRD17 YY1AP1 DTX2 EP300	6.30e-06	396	51	8	int:FHL2
Interaction	NR1I2 interactions	NCOR1 NCOA1 RXRA EP300	6.52e-06	48	51	4	int:NR1I2
Interaction	PRR20A interactions	ZC3H10 VEZF1 BANP YY1AP1 CCNK	8.13e-06	109	51	5	int:PRR20A
Interaction	SIRT1 interactions	NCOR1 RBM25 TOPBP1 FOXO4 IRS2 RXRA EP300 PRRC2B	8.41e-06	412	51	8	int:SIRT1
Interaction	KLF5 interactions	NCOR1 BCL9 RXRA EP300 PRRC2B TBP	9.53e-06	195	51	6	int:KLF5
Interaction	TOP3B interactions	SETD1A NCOR1 SYNJ1 ZMIZ2 BANP ANKRD17 ZFYVE26 IRS2 DTX2 BCL9 WDR59 EP300 RYR1 PRRC2B	1.13e-05	1470	51	14	int:TOP3B
Interaction	BCL3 interactions	NCOA1 RXRA EP300 TBP	1.21e-05	56	51	4	int:BCL3
Interaction	RARG interactions	NCOR1 NCOA1 RXRA EP300	1.40e-05	58	51	4	int:RARG
Interaction	NR1H3 interactions	NCOR1 NCOA1 RXRA EP300	1.40e-05	58	51	4	int:NR1H3
Interaction	SMG7 interactions	NCOR1 TCF20 DACH1 NCOA1 ANKRD17 BCL9 PRRC2B	1.49e-05	319	51	7	int:SMG7
Interaction	HDAC1 interactions	NCOR1 RBM25 TCF20 SYNJ1 SF3A1 ZMIZ2 BANP DACH1 ANKRD17 IRS2 EP300 TBP	1.55e-05	1108	51	12	int:HDAC1
Interaction	VDR interactions	NCOR1 NCOA1 FOXO4 RXRA EP300	1.71e-05	127	51	5	int:VDR
Interaction	LRRC37A11P interactions	ZMIZ2 SETBP1	1.88e-05	3	51	2	int:LRRC37A11P
Interaction	PAX9 interactions	NCOR1 TCF20 ZMIZ2 BCL9 EP300	1.91e-05	130	51	5	int:PAX9
Interaction	SMARCA4 interactions	NCOR1 RBM25 SF3A1 ZMIZ2 TOPBP1 NCOA1 RXRA EP300	1.92e-05	462	51	8	int:SMARCA4
Interaction	RBPMS interactions	ZC3H10 VEZF1 BANP DTX2 RAD54L2 CCNK PRRC2B	2.24e-05	340	51	7	int:RBPMS
Interaction	GCM1 interactions	NCOR1 BCL9 EP300 PRRC2B	2.63e-05	68	51	4	int:GCM1
Interaction	PIAS1 interactions	NCOR1 ZMIZ2 SPOP DTX2 RAD54L2 EP300 TBP	2.84e-05	353	51	7	int:PIAS1
Interaction	NR6A1 interactions	NCOR1 NCOA1 EP300	2.98e-05	24	51	3	int:NR6A1
Interaction	NCOA6 interactions	SETD1A NCOA1 RXRA EP300 TBP	3.24e-05	145	51	5	int:NCOA6
Interaction	AMPH interactions	SYNJ1 SNAP91 ITSN1 ITSN2	3.30e-05	72	51	4	int:AMPH
Interaction	NCOA1 interactions	NCOR1 NCOA1 RXRA EP300 TBP	3.35e-05	146	51	5	int:NCOA1
Interaction	NCOR1 interactions	NCOR1 SF3A1 DACH1 NCOA1 DTX2 RXRA EP300	3.40e-05	363	51	7	int:NCOR1
Interaction	CREB1 interactions	NCOR1 BRD8 DACH1 ANKRD17 WDR59 EP300	4.23e-05	254	51	6	int:CREB1
Interaction	CPSF1 interactions	NCOR1 RBM25 TCF20 DACH1 EP300 TBP	4.33e-05	255	51	6	int:CPSF1
Interaction	SFN interactions	MIIP SETD1A RBM25 BANP ANKRD17 FOXO4 IRS2 DTX2 MAP3K21	5.26e-05	692	51	9	int:SFN
Interaction	SOX7 interactions	TCF20 ZMIZ2 NCOA1 EP300	5.50e-05	82	51	4	int:SOX7
Interaction	PGR interactions	NCOR1 NCOA1 SPOP EP300	6.04e-05	84	51	4	int:PGR
Interaction	IRF4 interactions	TCF20 ZMIZ2 EP300 PRRC2B	6.33e-05	85	51	4	int:IRF4
Interaction	TERF2IP interactions	ZC3H10 SETD1A NCOR1 BRD8 TCF20 BANP TOPBP1 DACH1	6.80e-05	552	51	8	int:TERF2IP
Interaction	TFAP2D interactions	NCOR1 DTX2 RAD54L2 EP300	7.58e-05	89	51	4	int:TFAP2D
Interaction	YWHAH interactions	MIIP AMER1 TCF20 SYNJ1 MTM1 NCOA1 ANKRD17 FOXO4 IRS2 SPOP MAP3K21	7.85e-05	1102	51	11	int:YWHAH
Interaction	PRR20B interactions	ZC3H10 VEZF1 BANP CCNK	7.92e-05	90	51	4	int:PRR20B
Interaction	PRR20C interactions	ZC3H10 VEZF1 BANP CCNK	7.92e-05	90	51	4	int:PRR20C
Interaction	PRR20D interactions	ZC3H10 VEZF1 BANP CCNK	7.92e-05	90	51	4	int:PRR20D
Interaction	TLX1 interactions	NCOR1 TCF20 DACH1 BCL9 EP300	7.93e-05	175	51	5	int:TLX1
Interaction	TEAD1 interactions	NCOR1 DACH1 NCOA1 EP300 TBP	8.14e-05	176	51	5	int:TEAD1
Interaction	PATL1 interactions	SF3A1 ITSN1 ANKRD17 EP300 PRRC2B	8.36e-05	177	51	5	int:PATL1
Interaction	PPARA interactions	NCOR1 NCOA1 RXRA EP300	8.62e-05	92	51	4	int:PPARA
Interaction	TAF1B interactions	ZC3H10 RXRA EP300 TBP	8.62e-05	92	51	4	int:TAF1B
Interaction	HSFY1 interactions	BANP DTX2 CCNK	8.64e-05	34	51	3	int:HSFY1
Interaction	WWTR1 interactions	NCOR1 RBM25 TCF20 SYNJ1 DTX2 EP300 PRRC2B	8.78e-05	422	51	7	int:WWTR1
Interaction	NUP35 interactions	NCOR1 TCF20 ANKRD17 DTX2 BCL9 EP300 PRRC2B	9.04e-05	424	51	7	int:NUP35
Interaction	RNPS1 interactions	RBM25 SF3A1 ITSN1 ITSN2 DACH1 CCNK EP300	9.18e-05	425	51	7	int:RNPS1
Interaction	RAD54L2 interactions	BANP DTX2 RAD54L2 RXRA	9.77e-05	95	51	4	int:RAD54L2
Interaction	PIAS3 interactions	ZMIZ2 SPOP EP300 TBP	9.77e-05	95	51	4	int:PIAS3
Interaction	AP2M1 interactions	AMER1 SYNJ1 SNAP91 ITSN1 ITSN2 IRS2 EP300	9.87e-05	430	51	7	int:AP2M1
Interaction	CLTB interactions	TCF20 SYNJ1 ITSN1 ITSN2 MAP3K21	1.03e-04	185	51	5	int:CLTB
Interaction	THRB interactions	NCOR1 BRD8 NCOA1 RXRA EP300	1.06e-04	186	51	5	int:THRB
Interaction	NFIA interactions	NCOR1 RBM25 DTX2 BCL9 EP300	1.11e-04	188	51	5	int:NFIA
Interaction	HNF1B interactions	NCOR1 DACH1 BCL9 EP300 PRRC2B	1.17e-04	190	51	5	int:HNF1B
Interaction	CREBBP interactions	SETD1A NCOR1 DACH1 NCOA1 FOXO4 RXRA EP300 TBP	1.20e-04	599	51	8	int:CREBBP
Interaction	PPARG interactions	NCOR1 BRD8 NCOA1 RAD54L2 RXRA EP300	1.20e-04	307	51	6	int:PPARG
Interaction	NFKB1 interactions	NCOR1 RBM25 BANP NCOA1 RXRA EP300	1.20e-04	307	51	6	int:NFKB1
Interaction	MYOD1 interactions	NCOR1 NCOA1 BCL9 RXRA EP300	1.29e-04	194	51	5	int:MYOD1
Interaction	FOS interactions	NCOR1 NCOA1 ANKRD17 BCL9 EP300 TBP	1.32e-04	312	51	6	int:FOS
Interaction	TBX2 interactions	NCOR1 DACH1 EP300	1.41e-04	40	51	3	int:TBX2
Interaction	GATA2 interactions	NCOR1 BCL9 RXRA EP300 PRRC2B	1.45e-04	199	51	5	int:GATA2
Interaction	NPAS2 interactions	RBM25 RXRA EP300	1.63e-04	42	51	3	int:NPAS2
Interaction	JUN interactions	NCOR1 TCF20 BANP DACH1 NCOA1 EP300 TBP	1.71e-04	470	51	7	int:JUN
Interaction	SMC5 interactions	NCOR1 RBM25 BRD8 TCF20 VEZF1 SNAP91 SF3A1 TOPBP1 DACH1 CCNK	1.73e-04	1000	51	10	int:SMC5
Interaction	PAX8 interactions	NCOR1 BCL9 EP300 PRRC2B	1.78e-04	111	51	4	int:PAX8
Interaction	THRA interactions	NCOR1 NCOA1 RXRA EP300	1.78e-04	111	51	4	int:THRA
Interaction	SNRNP40 interactions	NCOR1 RBM25 TCF20 VEZF1 SF3A1 ZMIZ2 ITSN2 BCL9	1.83e-04	637	51	8	int:SNRNP40
Interaction	TBXT interactions	NCOR1 TCF20 BCL9 EP300	2.11e-04	116	51	4	int:TBXT
Interaction	NR3C2 interactions	NCOA1 RXRA EP300	2.15e-04	46	51	3	int:NR3C2
Interaction	PPARD interactions	NCOR1 NCOA1 RXRA EP300	2.18e-04	117	51	4	int:PPARD
Interaction	ELK3 interactions	SETD1A BRD8 VEZF1 DACH1	2.41e-04	120	51	4	int:ELK3
Interaction	NR1I3 interactions	NCOR1 NCOA1 RXRA	2.44e-04	48	51	3	int:NR1I3
Interaction	ETS1 interactions	NCOR1 NCOA1 EP300 TBP	2.48e-04	121	51	4	int:ETS1
Interaction	NPRL2 interactions	BANP WDR59 EP300 TBP	2.48e-04	121	51	4	int:NPRL2
Interaction	FOSB interactions	ZC3H10 VEZF1 EP300	2.59e-04	49	51	3	int:FOSB
Interaction	PAX7 interactions	NCOR1 DACH1 BCL9 EP300	2.73e-04	124	51	4	int:PAX7
Interaction	SGIP1 interactions	ITSN1 MTM1 ITSN2	2.75e-04	50	51	3	int:SGIP1
Interaction	SRCAP interactions	NCOR1 BRD8 SF3A1 EP300	2.99e-04	127	51	4	int:SRCAP
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	NCOA1 EP300	5.44e-04	17	37	2	486
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	ZFYVE26 RUFY3	1.83e-03	31	37	2	81
GeneFamily	Phosphoinositide phosphatases	SYNJ1 MTM1	1.94e-03	32	37	2	1079
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ITSN1 ITSN2	2.46e-03	36	37	2	823
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ITSN1 ITSN2	8.05e-03	66	37	2	722
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	SH3BP2 ITSN1 IRS2	8.52e-03	206	37	3	682
Coexpression	GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN	MIIP SETD1A ZMIZ2 SH3BP2 FOXO4 RAD54L2 SEC31B	5.16e-06	338	53	7	M17094
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RBM25 SH3BP2 MUC16 IRS2 RXRA	2.80e-06	186	53	5	23b8d51d20b05795a73892d3e20e0f9b6a207820
Drug	Sulfamethazine sodium salt [1981-58-4]; Down 200; 13.4uM; MCF7; HT_HG-U133A	NCOR1 SYNJ1 SH3BP2 DACH1 NCOA1 BCL9 RUFY3	3.03e-07	196	52	7	3422_DN
Drug	Pregnenolone [145-13-1]; Down 200; 12.6uM; MCF7; HT_HG-U133A	SETD1A SH3BP2 DACH1 NCOA1 RAD54L2 BCL9 RUFY3	3.03e-07	196	52	7	4802_DN
Drug	tetrac	NCOR1 BRD8 NCOA1 EP300	5.51e-07	29	52	4	CID000065552
Drug	L-165041	NCOR1 NCOA1 EP300 RYR1	1.35e-06	36	52	4	CID006603901
Drug	Dihydroergotamine tartrate [5989-77-5]; Down 200; 3uM; PC3; HT_HG-U133A	PER3 SYNJ1 ZMIZ2 ITSN1 RAD54L2 RUFY3	5.36e-06	195	52	6	4502_DN
Drug	Glibenclamide [10238-21-8]; Up 200; 8uM; HL60; HG-U133A	MIIP ZMIZ2 SH3BP2 ITSN1 RXRA RUFY3	5.52e-06	196	52	6	1546_UP
Drug	Propidium iodide [25535-16-4]; Up 200; 6uM; HL60; HT_HG-U133A	SYNJ1 ITSN1 NCOA1 FOXO4 WDR59 RUFY3	5.68e-06	197	52	6	2541_UP
Drug	Thioridazine hydrochloride [130-61-0]; Down 200; 9.8uM; MCF7; HT_HG-U133A	RBM25 PER3 SYNJ1 PRR36 DACH1 RAD54L2	5.68e-06	197	52	6	4164_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	MIIP SH3BP2 DACH1 EP300 RUFY3 PRRC2B	5.85e-06	198	52	6	3332_DN
Drug	Todralazine hydrochloride [3778-76-5]; Down 200; 14.8uM; MCF7; HT_HG-U133A	MIIP PRR36 SF3A1 MTM1 NCOA1 ZFYVE26	5.85e-06	198	52	6	1677_DN
Drug	Furaltadone hydrochloride [3759-92-0]; Down 200; 11uM; PC3; HT_HG-U133A	MIIP SYNJ1 ZMIZ2 SH3BP2 RUFY3 PRRC2B	5.85e-06	198	52	6	3756_DN
Drug	AC1L2E0P	NCOR1 BRD8 NCOA1 SPOP RXRA EP300 TBP	6.02e-06	307	52	7	CID000019390
Drug	PK 11195	NCOR1 NCOA1 RXRA	7.47e-06	17	52	3	ctd:C037850
Drug	androst-2-en-3-ol	NCOR1 NCOA1 RXRA	8.95e-06	18	52	3	CID000166036
Drug	lithocholic acid acetate	NCOR1 NCOA1 RXRA	2.81e-05	26	52	3	ctd:C502354
Drug	A-30	RYR1 TBP	3.06e-05	4	52	2	CID003028528
Drug	halofenate	NCOR1 EP300	3.06e-05	4	52	2	CID000033584
Drug	2,3,4,6-Tetrachloroanisole	RYR1 TBP	3.06e-05	4	52	2	CID000013647
Drug	Azaguanine-8 [134-58-7]; Down 200; 26.2uM; PC3; HT_HG-U133A	BRD8 ANKRD17 ZFYVE26 WDR59 RUFY3	5.77e-05	181	52	5	1791_DN
Drug	Solasodine [126-17-0]; Down 200; 9.6uM; MCF7; HT_HG-U133A	RBM25 MTM1 DACH1 BCL9 RUFY3	7.63e-05	192	52	5	6025_DN
Drug	2,4,6-trichloroanisole	RYR1 TBP	7.63e-05	6	52	2	CID000006884
Drug	Mexiletine hydrochloride [5370-01-4]; Down 200; 18.6uM; MCF7; HT_HG-U133A	SETD1A PRR36 ZMIZ2 SETBP1 RAD54L2	7.82e-05	193	52	5	3973_DN
Drug	Methylprednisolone, 6-alpha [83-43-2]; Down 200; 10.6uM; PC3; HT_HG-U133A	RAD54L2 BCL9 EP300 RUFY3 PRRC2B	8.01e-05	194	52	5	7137_DN
Drug	Zardaverine [101975-10-4]; Up 200; 15uM; MCF7; HT_HG-U133A	ZMIZ2 IRS2 RAD54L2 BCL9 RYR1	8.01e-05	194	52	5	7347_UP
Drug	F0447-0125; Down 200; 10uM; MCF7; HT_HG-U133A	MIIP RBM25 ZMIZ2 MTM1 DACH1	8.21e-05	195	52	5	6424_DN
Drug	SC-560; Up 200; 10uM; MCF7; HT_HG-U133A	RBM25 PER3 DACH1 BCL9 RUFY3	8.21e-05	195	52	5	6913_UP
Drug	Trimeprazine tartrate [4330-99-8]; Up 200; 5.4uM; MCF7; HT_HG-U133A	SETD1A PRR36 ZMIZ2 RAD54L2 BCL9	8.21e-05	195	52	5	3478_UP
Drug	Mephentermine hemisulfate [1212-72-2]; Down 200; 9.4uM; MCF7; HT_HG-U133A	MIIP PER3 IRS2 RAD54L2 WDR59	8.21e-05	195	52	5	4707_DN
Drug	Tiaprofenic acid [33005-95-7]; Down 200; 15.4uM; MCF7; HT_HG-U133A	MIIP ITSN1 RAD54L2 BCL9 EP300	8.21e-05	195	52	5	2852_DN
Drug	Naringenine [480-41-1]; Up 200; 14.6uM; MCF7; HT_HG-U133A	MIIP SETD1A SH3BP2 ITSN1 MTM1	8.21e-05	195	52	5	3278_UP
Drug	Midodrine hydrochloride [3092-17-9]; Up 200; 13.8uM; PC3; HT_HG-U133A	ZMIZ2 BCL9 RXRA RUFY3 PRRC2B	8.21e-05	195	52	5	2087_UP
Drug	Naringenine [480-41-1]; Down 200; 14.6uM; PC3; HT_HG-U133A	MIIP ZMIZ2 SETBP1 IRS2 RAD54L2	8.21e-05	195	52	5	4597_DN
Drug	(-)-Eseroline fumarate salt [104015-29-4]; Down 200; 12uM; MCF7; HT_HG-U133A	NCOR1 SF3A1 SH3BP2 ITSN1 RUFY3	8.41e-05	196	52	5	7027_DN
Drug	Pantothenic acid calcium salt monohydrate [63409-48-3]; Up 200; 8uM; HL60; HT_HG-U133A	SETD1A ZMIZ2 NCOA1 SEC31B PRRC2B	8.41e-05	196	52	5	1311_UP
Drug	Prilocaine hydrochloride [1786-81-8]; Down 200; 15.6uM; MCF7; HT_HG-U133A	MIIP ZMIZ2 SH3BP2 ZFYVE26 BCL9	8.41e-05	196	52	5	2314_DN
Drug	Lysergol [602-85-7]; Up 200; 15.8uM; MCF7; HT_HG-U133A	ZMIZ2 ITSN1 MTM1 IRS2 RUFY3	8.41e-05	196	52	5	3261_UP
Drug	Pramoxine hydrochloride [637-58-1]; Down 200; 12.2uM; HL60; HT_HG-U133A	PER3 ITSN1 DACH1 RUFY3 PRRC2B	8.41e-05	196	52	5	2198_DN
Drug	3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Up 200; 13.8uM; PC3; HT_HG-U133A	PRR36 ZMIZ2 SH3BP2 DACH1 FOXO4	8.41e-05	196	52	5	3742_UP
Drug	Amikacin hydrate [37517-28-5]; Down 200; 6.6uM; MCF7; HT_HG-U133A	MIIP PRR36 RAD54L2 BCL9 WDR59	8.41e-05	196	52	5	3233_DN
Drug	Triflupromazine hydrochloride [1098-60-8]; Down 200; 10.2uM; MCF7; HT_HG-U133A	MIIP SF3A1 MTM1 DACH1 NCOA1	8.41e-05	196	52	5	1691_DN
Drug	Miconazole [22916-47-8]; Up 200; 9.6uM; PC3; HT_HG-U133A	SH3BP2 DACH1 WDR59 RYR1 RUFY3	8.41e-05	196	52	5	6615_UP
Drug	Bupropion hydrochloride [31677-93-7]; Up 200; 14.4uM; HL60; HG-U133A	NCOR1 ITSN1 ITSN2 EP300 PRRC2B	8.61e-05	197	52	5	1564_UP
Drug	Hexestrol [84-16-2]; Down 200; 14.8uM; MCF7; HT_HG-U133A	SETD1A ITSN1 NCOA1 WDR59 EP300	8.61e-05	197	52	5	6077_DN
Drug	Tolbutamide [64-77-7]; Down 200; 14.8uM; MCF7; HT_HG-U133A	PRR36 ZMIZ2 DACH1 IRS2 RAD54L2	8.61e-05	197	52	5	3886_DN
Drug	LY 294002; Down 200; 0.1uM; MCF7; HT_HG-U133A	MIIP PRR36 SH3BP2 BCL9 RUFY3	8.61e-05	197	52	5	1641_DN
Drug	Meticrane [1084-65-7]; Down 200; 14.6uM; MCF7; HT_HG-U133A	MIIP PRR36 SH3BP2 ITSN1 DACH1	8.61e-05	197	52	5	1671_DN
Drug	troglitazone; Up 200; 10uM; MCF7; HT_HG-U133A	SH3BP2 DACH1 MUC16 WDR59 RUFY3	8.61e-05	197	52	5	6991_UP
Drug	Cefotiam hydrochloride; Up 200; 7.2uM; MCF7; HT_HG-U133A	ZMIZ2 FOXO4 IRS2 RYR1 RUFY3	8.61e-05	197	52	5	3319_UP
Drug	Mephenesin [59-47-2]; Down 200; 22uM; MCF7; HT_HG-U133A	SETD1A PER3 SH3BP2 BCL9 RUFY3	8.61e-05	197	52	5	2304_DN
Drug	Florfenicol [73231-34-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A	MIIP RBM25 ITSN1 NCOA1 RUFY3	8.61e-05	197	52	5	5300_DN
Drug	Pentolinium bitartrate [52-62-0]; Down 200; 7.4uM; MCF7; HT_HG-U133A	PRR36 ZMIZ2 SH3BP2 DACH1 BCL9	8.61e-05	197	52	5	4699_DN
Drug	Aconitine [302-27-2]; Up 200; 6.2uM; MCF7; HT_HG-U133A	PER3 PRR36 DACH1 FOXO4 CCNK	8.61e-05	197	52	5	6797_UP
Drug	Lidocaone hydrochloride [73-78-9]; Down 200; 14.8uM; MCF7; HT_HG-U133A	MIIP PRR36 SH3BP2 ITSN1 DACH1	8.61e-05	197	52	5	1499_DN
Drug	Pseudopelletierine hydrochloride [6164-62-1]; Up 200; 21uM; MCF7; HT_HG-U133A	SETD1A PRR36 RAD54L2 BCL9 PRRC2B	8.61e-05	197	52	5	2766_UP
Drug	Ganciclovir [82410-32-0]; Down 200; 15.6uM; MCF7; HT_HG-U133A	NCOR1 MTM1 DACH1 IRS2 RUFY3	8.82e-05	198	52	5	5389_DN
Drug	Pinacidil [85371-64-8]; Down 200; 16.4uM; MCF7; HT_HG-U133A	SETD1A SH3BP2 MTM1 BANP NCOA1	8.82e-05	198	52	5	7437_DN
Drug	Ampicillin trihydrate [7177-48-2]; Down 200; 10uM; MCF7; HT_HG-U133A	MIIP SH3BP2 DACH1 ZFYVE26 RUFY3	8.82e-05	198	52	5	1530_DN
Drug	Ribostamycin sulfate salt [53797-35-6]; Up 200; 7.2uM; MCF7; HT_HG-U133A	RBM25 PER3 PRR36 SH3BP2 IRS2	8.82e-05	198	52	5	6765_UP
Drug	Cinnarizine [298-57-7]; Down 200; 10.8uM; MCF7; HT_HG-U133A	NCOA1 IRS2 RAD54L2 CCNK RUFY3	8.82e-05	198	52	5	3175_DN
Drug	Halcinonide [3093-35-4]; Down 200; 8.8uM; MCF7; HT_HG-U133A	MIIP PER3 PRR36 MTM1 RAD54L2	8.82e-05	198	52	5	4703_DN
Drug	Chlorprothixene hydrochloride [6469-93-8]; Up 200; 11.4uM; HL60; HT_HG-U133A	MIIP MTM1 DACH1 NCOA1 FOXO4	8.82e-05	198	52	5	1272_UP
Drug	Propidium iodide [25535-16-4]; Down 200; 6uM; MCF7; HT_HG-U133A	SETD1A SH3BP2 DACH1 WDR59 PRRC2B	8.82e-05	198	52	5	6104_DN
Drug	ICI 182,780; Down 200; 1uM; PC3; HT_HG-U133A	MIIP SYNJ1 IRS2 BCL9 RUFY3	9.03e-05	199	52	5	1205_DN
Drug	Diltiazem hydrochloride [33286-22-5]; Down 200; 8.8uM; MCF7; HT_HG-U133A	RBM25 ITSN1 MTM1 NCOA1 PRRC2B	9.03e-05	199	52	5	5309_DN
Drug	Eucatropine hydrochloride [536-93-6]; Down 200; 12.2uM; PC3; HT_HG-U133A	MIIP SETD1A SYNJ1 SH3BP2 WDR59	9.03e-05	199	52	5	3759_DN
Drug	Phentolamine hydrochloride [73-05-2]; Down 200; 12.6uM; MCF7; HT_HG-U133A	MIIP PRR36 SH3BP2 RAD54L2 RUFY3	9.03e-05	199	52	5	3860_DN
Drug	Paromomycin sulfate [1263-89-4]; Down 200; 5.6uM; HL60; HT_HG-U133A	SYNJ1 SH3BP2 NCOA1 RXRA RUFY3	9.03e-05	199	52	5	3017_DN
Drug	Vinpocetine [42971-09-5]; Down 200; 11.4uM; HL60; HG-U133A	SH3BP2 MTM1 ITSN2 NCOA1 PRRC2B	9.03e-05	199	52	5	1557_DN
Drug	Flucloxacillin sodium [1847-24-1]; Down 200; 8.4uM; HL60; HT_HG-U133A	SETD1A SH3BP2 SETBP1 FOXO4 RUFY3	9.03e-05	199	52	5	3128_DN
Drug	Verapamyl hydrochloride [152-11-4]; Down 200; 8.2uM; MCF7; HT_HG-U133A	MIIP ZMIZ2 SH3BP2 IRS2 WDR59	9.03e-05	199	52	5	1509_DN
Drug	Chlorhexidine [55-56-1]; Down 200; 8uM; MCF7; HT_HG-U133A	SETD1A SH3BP2 DACH1 IRS2 RUFY3	9.25e-05	200	52	5	5403_DN
Drug	mono-(2-ethylhexyl)phthalate	NCOR1 PER3 DACH1 NCOA1 IRS2 RXRA EP300 RYR1	1.14e-04	658	52	8	ctd:C016599
Drug	CV-1	NCOR1 BRD8 NCOA1 RXRA EP300	1.24e-04	213	52	5	CID000130105
Drug	ormeloxifene	NCOR1 NCOA1	1.42e-04	8	52	2	ctd:C508548
Drug	DHBT	SYNJ1 SNAP91 ITSN2 RYR1	1.58e-04	119	52	4	CID000001855
Drug	AC1L9K70	BRD8 NCOA1 RXRA EP300 TBP	1.71e-04	228	52	5	CID000446871
Drug	ammonium acetate	TCF20 KNG1	1.82e-04	9	52	2	CID000012432
Drug	pentachloroanisole	RYR1 TBP	2.28e-04	10	52	2	CID000015767
Drug	Methyltestosterone	NCOA1 RXRA KNG1	2.57e-04	54	52	3	ctd:D008777
Drug	2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3	NCOA1 RXRA	2.78e-04	11	52	2	ctd:C061137
Drug	Androstenols	NCOR1 NCOA1	3.33e-04	12	52	2	ctd:D000737
Drug	2,4,6-tribromoanisole	RYR1 TBP	3.33e-04	12	52	2	CID000011839
Drug	dihydroxy-vitamin D3	NCOA1 RXRA	3.93e-04	13	52	2	ctd:C118756
Drug	steroid D	NCOR1 NCOA1	3.93e-04	13	52	2	CID000454475
Drug	azaperone	SNAP91 RYR1	4.57e-04	14	52	2	CID000015443
Drug	4-methylbenzylidene camphor	NCOR1 NCOA1	6.01e-04	16	52	2	CID006434217
Drug	In-G	SETD1A NCOA1 EP300 TBP	6.14e-04	170	52	4	CID000446054
Drug	rottlerin; Up 200; 10uM; MCF7; HT_HG-U133A_EA	ZMIZ2 SH3BP2 IRS2 RYR1	6.14e-04	170	52	4	941_UP
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A	BANP RXRA EP300 RUFY3	6.14e-04	170	52	4	7043_DN
Drug	glutamin	NCOR1 SNAP91 MTM1 NCOA1 EP300 TBP	6.17e-04	461	52	6	CID000000738
Drug	DBTC	SNAP91 YY1AP1 RYR1	6.24e-04	73	52	3	CID000101938
Drug	phthalic acid	NCOA1 RXRA	6.81e-04	17	52	2	ctd:C032279
Drug	tetrachlorobisphenol A	BRD8 TBP	6.81e-04	17	52	2	CID000006619
Drug	Trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A_EA	BANP RXRA EP300 RUFY3	6.85e-04	175	52	4	1014_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	ZMIZ2 SH3BP2 BANP RUFY3	6.99e-04	176	52	4	4632_DN
Drug	AC1L9M2J	NCOR1 NCOA1 EP300	7.02e-04	76	52	3	CID000448538
Drug	SAHA; Down 200; 10uM; MCF7; HT_HG-U133A	BANP RXRA EP300 RUFY3	7.14e-04	177	52	4	1645_DN
Drug	fluphenazine dihydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A	SYNJ1 PRR36 ZMIZ2 IRS2	7.30e-04	178	52	4	5234_UP
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	RAD54L2 RXRA EP300 RUFY3	7.45e-04	179	52	4	6609_DN
Drug	Flurandrenolide [1524-88-5]; Up 200; 9.2uM; HL60; HT_HG-U133A	MIIP ZMIZ2 SH3BP2 RUFY3	7.45e-04	179	52	4	2184_UP
Disease	Autosomal Dominant Myotubular Myopathy	MTM1 RYR1	2.35e-04	13	52	2	C3661489
Disease	Centronuclear myopathy	MTM1 RYR1	2.35e-04	13	52	2	C0175709
Disease	X-linked centronuclear myopathy	MTM1 RYR1	2.35e-04	13	52	2	C0410203
Disease	Congenital Structural Myopathy	MTM1 RYR1	2.35e-04	13	52	2	C0752282
Disease	Myopathy, Centronuclear, 1	MTM1 RYR1	2.35e-04	13	52	2	C4551952
Disease	Myopathy, Centronuclear, Autosomal Dominant	MTM1 RYR1	2.73e-04	14	52	2	C1834558
Disease	Tubular Aggregate Myopathy	MTM1 RYR1	2.73e-04	14	52	2	C0410207
Disease	diffuse large B-cell lymphoma	ITSN2 NCOA1	2.73e-04	14	52	2	EFO_0000403
Disease	Mammary Carcinoma, Human	NCOR1 PER3 SETBP1 ITSN2 NCOA1 EP300	3.14e-04	525	52	6	C4704874
Disease	Mammary Neoplasms, Human	NCOR1 PER3 SETBP1 ITSN2 NCOA1 EP300	3.14e-04	525	52	6	C1257931
Disease	Autosomal Recessive Centronuclear Myopathy	MTM1 RYR1	3.15e-04	15	52	2	C3645536
Disease	intellectual disability (implicated_via_orthology)	ITSN1 ITSN2 IRS2	3.19e-04	75	52	3	DOID:1059 (implicated_via_orthology)
Disease	Mammary Neoplasms	NCOR1 PER3 SETBP1 ITSN2 NCOA1 EP300	3.20e-04	527	52	6	C1458155
Disease	Breast Carcinoma	NCOR1 PER3 SETBP1 ITSN2 NCOA1 EP300	3.57e-04	538	52	6	C0678222
Disease	Congenital Fiber Type Disproportion	MTM1 RYR1	4.58e-04	18	52	2	C0546264
Disease	fat intake measurement	ITSN2 NCOA1	6.88e-04	22	52	2	EFO_0010809
Disease	Prostatic Neoplasms	NCOR1 ITSN1 ITSN2 NCOA1 SPOP RXRA	7.28e-04	616	52	6	C0033578
Disease	Malignant neoplasm of prostate	NCOR1 ITSN1 ITSN2 NCOA1 SPOP RXRA	7.28e-04	616	52	6	C0376358
Disease	partial thromboplastin time	CUX2 KNG1	8.20e-04	24	52	2	EFO_0004310
Disease	congestive heart failure (is_implicated_in)	EP300 RYR1	1.04e-03	27	52	2	DOID:6000 (is_implicated_in)
Disease	necrotizing enterocolitis	TCF20 BANP	1.04e-03	27	52	2	EFO_0003928
Disease	Alzheimer's disease (is_marker_for)	SNAP91 IRS2 EP300 TBP	1.10e-03	257	52	4	DOID:10652 (is_marker_for)
Disease	Myeloid Leukemia, Chronic	PER3 SETBP1	1.20e-03	29	52	2	C0023473
Disease	colorectal cancer (is_implicated_in)	AMER1 SPOP EP300	1.28e-03	121	52	3	DOID:9256 (is_implicated_in)
Disease	testosterone measurement	CUX2 AMER1 PER3 BANP DACH1 NCOA1 YY1AP1 RXRA	1.65e-03	1275	52	8	EFO_0004908

Protein segments in the cluster

Peptide	Gene	Start	Entry
SEPMMSTPPPASELP	BANP	346	Q8N9N5
MSSSSCPVNSPIMPP	EP300	796	Q09472
MMPALPAPSSAPAVS	BRD8	311	Q9H0E9
RMSDPPLSTMPTAPG	SH3BP2	276	P78314
PPPPPSSYMTGMSTT	CCNK	421	O75909
IPPMTMSISLSVPES	AMER1	996	Q5JTC6
APVSMVPPSPAMAAS	SNAP91	736	O60641
PSTPARAPATSAPMM	AHI1-DT	61	P0C7V0
ASVRPVQSTPIPMMP	RAD54L2	1021	Q9Y4B4
STAPVTYPMPQTPMG	ANKRD17	2151	O75179
LMMSVSPVPSSSAPI	CUX2	1406	O14529
IPVSLPPASVTMAMS	DACH1	441	Q9UI36
IMAPAPTVLVPTVSM	RBM25	46	P49756
PLMMPTPLVPSVSTS	ITSN2	151	Q9NZM3
SPMSTFAIFPPMSTP	MUC16	1481	Q8WXI7
MDLPSPTPSMEVTPW	MUC16	1816	Q8WXI7
MPSPAMTSPPVSSTL	MUC16	6806	Q8WXI7
SVPATVPMQMPKPSR	DTX2	316	Q86UW9
PSMSSAMSPTLDPPP	PER3	881	P56645
LSMIAPPPVMASAPI	FOXO4	431	P98177
MTPETNTPETTMPPS	DEFB125	111	Q8N687
TMPPSEATTPETTMP	DEFB125	121	Q8N687
LSATVPSPPPMTVSM	LRRC63	196	Q05C16
MSMPVAHSPPAATSP	IRS2	431	Q9Y4H2
MSPPSSMCSPVPLLA	VENTXP1	1	P0C5K6
VMVRPPTVMSPSGNP	BCL9	26	O00512
ASMPPLTAVAPVPMG	ITSN1	121	Q15811
SDLIATMMPPISPAP	KNG1	566	P01042
PMGPHSMSVPTTPTL	RXRA	71	P19793
AMMTQPPATPTLPRL	RYR1	1396	P21817
MSALTPPTDMPTPTT	RUFY3	1	Q7L099
VLSSVSCMPTMPPIP	SYNJ1	1366	O43426
SSSPPSSPTMMPRLR	MAP3K21	541	Q5TCX8
APSLSPGSSMVPMPI	NCOA1	1246	Q15788
MTTPPMQAPPSLQTI	PRR36	571	Q9H6K5
NPLTMRMLSSTPPTP	NCOR1	2386	O75376
ASPMQMLPPTPTWSV	MIIP	361	Q5JXC2
ETFMPPAPITAPVMS	SEC31B	1011	Q9NQW1
TTPQPFTTMQPTTMP	SSC5D	1261	A1L4H1
VSAVPVMPRPPMASV	SF3A1	591	Q15459
PMPMAAEPLPSSSVS	SETD1A	751	O15047
TITSPMNLPTPMTLA	VEZF1	481	Q14119
PTSPSSPSQMMPHVQ	MTM1	586	Q13496
TPLYPSPMTPMTPIT	TBP	136	P20226
SPMTPMTPITPATPA	TBP	141	P20226
MSRVPSPPPPAEMSS	SPOP	1	O43791
SSQPLPMSPPSTTRM	TMPRSS9	736	Q7Z410
GVSMPPMPVASVAPS	PRRC2B	1901	Q5JSZ5
PQLSPTPSMMPSPNS	TCF20	416	Q9UGU0
PSVPMVSPLPMASSV	RHCG	461	Q9UBD6
PPMTPSSSVPYMSPN	ZMIZ2	376	Q8NF64
PMTMHRAVSPTEPTP	WDR59	556	Q6PJI9
SAPVPKVMMPSPASS	YY1AP1	551	Q9H869
GMAPPPVSMAPVAVS	ZC3H10	376	Q96K80
PMVMTPPTCTDHSPS	SETBP1	501	Q9Y6X0
NPLFTPVPVMTGMTP	TOPBP1	631	Q92547
PQSSLIPMMFSPPES	ZFYVE26	821	Q68DK2