Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	mRNA processing	PCF11 SCAF11 SREK1 SRSF2 SRRM2 CDK12 SRSF8 LARP7	1.47e-06	551	32	8	GO:0006397
GeneOntologyBiologicalProcess	RNA splicing	SCAF11 SREK1 SRSF2 SRRM2 CDK12 SRSF8 LARP7	9.63e-06	502	32	7	GO:0008380
GeneOntologyBiologicalProcess	mRNA metabolic process	PCF11 SCAF11 SREK1 SRSF2 SRRM2 CDK12 SRSF8 LARP7	6.01e-05	917	32	8	GO:0016071
GeneOntologyBiologicalProcess	mRNA splicing, via spliceosome	SCAF11 SRSF2 SRRM2 SRSF8 LARP7	2.10e-04	358	32	5	GO:0000398
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	SCAF11 SRSF2 SRRM2 SRSF8 LARP7	2.10e-04	358	32	5	GO:0000377
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions	SCAF11 SRSF2 SRRM2 SRSF8 LARP7	2.21e-04	362	32	5	GO:0000375
GeneOntologyBiologicalProcess	RNA processing	PCF11 SCAF11 REXO4 SREK1 SRSF2 SRRM2 CDK12 SRSF8 LARP7	3.36e-04	1500	32	9	GO:0006396
GeneOntologyCellularComponent	nuclear body	SCAF11 REXO4 SREK1 SRSF2 ARIH1 SRRM2 CDK12 SRSF8 MDC1	7.61e-06	903	33	9	GO:0016604
GeneOntologyCellularComponent	nuclear speck	REXO4 SREK1 SRSF2 SRRM2 CDK12 SRSF8	5.13e-05	431	33	6	GO:0016607
Domain	RRM_1	SREK1 SRSF2 SRSF8 LARP7	4.75e-04	208	33	4	PF00076
Domain	RRM	SREK1 SRSF2 SRSF8 LARP7	5.57e-04	217	33	4	SM00360
Domain	RRM_dom	SREK1 SRSF2 SRSF8 LARP7	6.59e-04	227	33	4	IPR000504
Domain	RRM	SREK1 SRSF2 SRSF8 LARP7	6.93e-04	230	33	4	PS50102
Domain	-	SREK1 SRSF2 SRSF8 LARP7	8.63e-04	244	33	4	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	SREK1 SRSF2 SRSF8 LARP7	1.06e-03	258	33	4	IPR012677
Domain	HMG_box	UBTF CIC	3.94e-03	53	33	2	PF00505
Domain	HMG_BOX_2	UBTF CIC	4.09e-03	54	33	2	PS50118
Domain	HMG	UBTF CIC	4.09e-03	54	33	2	SM00398
Domain	-	UBTF CIC	4.24e-03	55	33	2	1.10.30.10
Domain	HMG_box_dom	UBTF CIC	5.87e-03	65	33	2	IPR009071
Domain	NA-bd_OB-fold	LIG1 DARS1	9.42e-03	83	33	2	IPR012340
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	PCF11 ZC3H11A NKAP SRSF2 SRRM2 SRSF8	7.97e-06	283	25	6	M13087
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	PCF11 ZC3H11A NKAP SRSF2 SRRM2	1.09e-04	277	25	5	MM15414
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION_TERMINATION	PCF11 ZC3H11A SRSF2	1.74e-04	62	25	3	MM15426
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION_TERMINATION	PCF11 ZC3H11A SRSF2	2.19e-04	67	25	3	M27694
Pathway	REACTOME_MRNA_SPLICING	NKAP SRSF2 SRRM2 SRSF8	4.91e-04	212	25	4	M14033
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PCF11 LIG1 SCAF11 UBA1 ZC3H11A NKAP SRSF2 KAT6B SRRM2 CDK12 CIC NOTCH2 MDC1	1.79e-13	774	34	13	15302935
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	HMGN5 SCAF11 UBA1 REXO4 ZC3H11A SREK1 NKAP SRSF2 SRRM2 UBTF SRSF8 LARP7	7.71e-12	807	34	12	22681889
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	PCF11 DARS1 SCAF11 REXO4 ZC3H11A SREK1 SRSF2 SRRM2 UBTF LARP7 MDC1	2.88e-10	847	34	11	35850772
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	PCF11 SCAF11 REXO4 ZC3H11A SREK1 NKAP SRSF2 ATP9A CDK12 CIC LARP7 MDC1 KIF2C	6.58e-10	1497	34	13	31527615
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	PCF11 SCAF11 REXO4 ZC3H11A SREK1 SRSF2 SRRM2 CDK12 UBTF CIC MDC1	1.00e-09	954	34	11	36373674
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	LIG1 SCAF11 UBA1 REXO4 ZC3H11A SREK1 SRSF2 SRRM2 UBTF MDC1 KIF2C	1.46e-09	989	34	11	36424410
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	HMGN5 LIG1 DARS1 SREK1 NKAP SRSF2 SRRM2 SRSF8 NOTCH2 LARP7 KIF2C	2.85e-08	1318	34	11	30463901
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	DARS1 SCAF11 UBA1 ZC3H11A SRRM2 MDC1 KIF2C	2.92e-08	332	34	7	32786267
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	DARS1 SCAF11 REXO4 ZC3H11A NKAP CDK12 UBTF LARP7 KIF2C	3.45e-08	759	34	9	35915203
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	SCAF11 REXO4 ZC3H11A SRSF2 SRRM2 UBTF LARP7 MDC1	1.75e-07	653	34	8	22586326
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	NAV1 DARS1 SCAF11 UBA1 REXO4 ZC3H11A UBTF MDC1 LAD1 KIF2C	2.18e-07	1257	34	10	36526897
Pubmed	The protein interaction landscape of the human CMGC kinase group.	NAV1 SREK1 NKAP SRSF2 SRRM2 CDK12 SRSF8 LARP7	2.80e-07	695	34	8	23602568
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	HMGN5 SCAF11 ZC3H11A SRSF2 SRRM2 UBTF CIC SRSF8 MDC1 KIF2C	2.85e-07	1294	34	10	30804502
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	PCF11 SCAF11 REXO4 ZC3H11A CDK12 MDC1	3.06e-07	283	34	6	30585729
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	ZC3H11A SREK1 NKAP SRSF2 SRRM2 CDK12 SRSF8 LARP7	3.40e-07	713	34	8	29802200
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	UBA1 REXO4 ZC3H11A SREK1 SRSF2 SRSF8 LARP7 KIF2C	3.78e-07	723	34	8	34133714
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	DARS1 REXO4 ZC3H11A NKAP SRSF2 SRRM2 CDK12 SRSF8	4.11e-07	731	34	8	29298432
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	PCF11 DARS1 SCAF11 REXO4 NKAP SRSF2 CDK12 SRSF8 LARP7 LAD1	4.84e-07	1371	34	10	36244648
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	DARS1 UBA1 SRRM2 CDK12 CIC LARP7 MDC1	5.07e-07	506	34	7	30890647
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DARS1 UBA1 REXO4 ZC3H11A SREK1 SRSF2 SRRM2 UBTF LARP7 MDC1	6.89e-07	1425	34	10	30948266
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	PCF11 LIG1 DARS1 UBA1 ZC3H11A SRRM2 UBTF CIC KIF2C	8.06e-07	1103	34	9	34189442
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	DARS1 UBA1 ZC3H11A SREK1 SRSF2 SRRM2 LARP7 KIF2C	8.80e-07	809	34	8	32129710
Pubmed	Ablation of ZC3H11A causes early embryonic lethality and dysregulation of metabolic processes.	ZC3H11A SRSF2	9.28e-07	2	34	2	37252988
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	PCF11 UBA1 ZC3H11A SRSF2 SRRM2 MDC1	2.25e-06	399	34	6	35987950
Pubmed	Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins.	SREK1 SRSF2	2.78e-06	3	34	2	11991645
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	SCAF11 SRSF2 SRRM2 CDK12 LARP7 MDC1 KIF2C	3.27e-06	670	34	7	22990118
Pubmed	The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes.	SRSF2 SRRM2	5.56e-06	4	34	2	10908574
Pubmed	CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles.	SRSF2 CDK12	5.56e-06	4	34	2	11683387
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	LIG1 UBA1 ZC3H11A SRSF2 SRRM2 CDK12	8.47e-06	503	34	6	16964243
Pubmed	Identification and characterization of a novel serine-arginine-rich splicing regulatory protein.	SREK1 SRSF2	9.26e-06	5	34	2	10757789
Pubmed	Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage.	UBA1 ZC3H11A CDK12 MDC1	1.63e-05	156	34	4	37108203
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	PCF11 SREK1 SRSF2 SRRM2 CDK12 KIF2C	1.93e-05	582	34	6	20467437
Pubmed	Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing.	SCAF11 SRSF2	1.94e-05	7	34	2	9447963
Pubmed	Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6.	UBA1 ARIH1 KIF2C	2.16e-05	55	34	3	36758106
Pubmed	Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.	PCF11 SRSF2 SRRM2 CDK12	2.28e-05	170	34	4	16159877
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	SCAF11 REXO4 SRRM2 UBTF LARP7 MDC1	2.40e-05	605	34	6	28977666
Pubmed	Regulation of alternative splicing by SRrp86 and its interacting proteins.	SREK1 SRSF2 SRSF8	2.41e-05	57	34	3	14559993
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	DARS1 ZC3H11A SRRM2 NOTCH2 MDC1	2.45e-05	358	34	5	32460013
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	HMGN5 SCAF11 REXO4 UBTF CIC MDC1	2.47e-05	608	34	6	36089195
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	PCF11 NKAP SRRM2 CDK12 MDC1	2.55e-05	361	34	5	26167880
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	DARS1 SRSF2 SRRM2 UBTF LARP7 KIF2C	2.63e-05	615	34	6	31048545
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DARS1 UBA1 REXO4 ZC3H11A SRRM2 UBTF MDC1 KIF2C	3.78e-05	1353	34	8	29467282
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	LIG1 UBA1 NKAP SRSF2 SRRM2 CIC	4.07e-05	665	34	6	30457570
Pubmed	Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.	UBA1 ARIH1	4.15e-05	10	34	2	32246052
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	UBA1 ZC3H11A ARIH1 CDK12 UBTF LARP7 MDC1	4.74e-05	1014	34	7	32416067
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	DARS1 UBA1 ZC3H11A SRSF2 SRRM2 UBTF MDC1	5.04e-05	1024	34	7	24711643
Pubmed	Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.	PCF11 SRSF2 CDK12 UBTF CIC	5.53e-05	425	34	5	24999758
Pubmed	Human transcription factor protein interaction networks.	PCF11 DARS1 SCAF11 REXO4 SRRM2 UBTF CIC MDC1	5.56e-05	1429	34	8	35140242
Pubmed	A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins).	SRSF2 SRSF8	7.19e-05	13	34	2	20516191
Pubmed	Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.	SRRM2 CDK12 MDC1	7.98e-05	85	34	3	16051665
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NAV1 ZC3H11A CDK12 CIC NOTCH2 LAD1 SCN5A	8.14e-05	1105	34	7	35748872
Pubmed	The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells.	DARS1 UBA1 SRSF2 SRRM2	8.58e-05	239	34	4	26641092
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SREK1 NKAP KAT6B SRRM2 NOTCH2 LARP7 SCN5A	8.66e-05	1116	34	7	31753913
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	PCF11 DARS1 UBA1 UBTF LARP7	8.80e-05	469	34	5	37314180
Pubmed	Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS.	SRSF2 ATP9A SRRM2 UBTF	9.44e-05	245	34	4	21182205
Pubmed	FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation.	ARIH1 NOTCH2	9.66e-05	15	34	2	31285543
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SCAF11 NKAP CDK12 SRSF8	1.04e-04	251	34	4	31076518
Pubmed	SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.	REXO4 NKAP KAT6B SRRM2	1.17e-04	259	34	4	30404004
Pubmed	Insights into the ubiquitin-proteasome system of human embryonic stem cells.	SREK1 NKAP CDK12 UBTF	1.35e-04	269	34	4	29511261
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	KAT6B SRRM2 CIC	1.45e-04	104	34	3	9205841
Pubmed	The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells.	SREK1 SRSF2 CDK12	1.45e-04	104	34	3	31365120
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	DARS1 ZC3H11A CIC NOTCH2 LARP7 KIF2C	1.64e-04	857	34	6	25609649
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	USP43 NAV1 SRRM2 CIC NOTCH2 KIF2C	1.68e-04	861	34	6	36931259
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	DARS1 SCAF11 UBA1 ZC3H11A KIF2C	1.87e-04	551	34	5	34728620
Pubmed	The formation and function of the cardiac conduction system.	NOTCH2 SCN5A	1.93e-04	21	34	2	26786210
Pubmed	Nde1 is required for heterochromatin compaction and stability in neocortical neurons.	UBA1 UBTF	1.93e-04	21	34	2	35601919
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	DARS1 UBA1 ZC3H11A CDK12 UBTF CIC	2.61e-04	934	34	6	33916271
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	DARS1 SCAF11 SRSF2 ARIH1 UBTF	2.79e-04	601	34	5	33658012
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	SCAF11 ZC3H11A SRRM2	2.81e-04	130	34	3	35545047
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	SCAF11 UBA1 SRSF2 KAT6B CIC	2.94e-04	608	34	5	16713569
Pubmed	The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.	DARS1 UBA1 ZC3H11A SRRM2	2.95e-04	330	34	4	32529326
Pubmed	SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination.	SRRM2 MDC1	3.21e-04	27	34	2	25703348
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	REXO4 SRRM2 LARP7 MDC1	3.64e-04	349	34	4	25665578
Pubmed	The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing.	SRRM2 MDC1	3.70e-04	29	34	2	17577209
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	NAV1 DARS1 SCAF11 UBA1 SRSF2 SRRM2 MDC1	3.72e-04	1415	34	7	28515276
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	DARS1 UBA1 SRRM2 LAD1	4.10e-04	360	34	4	33111431
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	DARS1 SREK1 NKAP SRRM2 UBTF	4.13e-04	655	34	5	35819319
Pubmed	Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.	NAV1 SRSF2 SRRM2 CDK12	4.14e-04	361	34	4	30344098
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	DARS1 SCAF11 REXO4 ARIH1	4.54e-04	370	34	4	22922362
Pubmed	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.	REXO4 SREK1 NKAP SRSF2 CDK12	4.83e-04	678	34	5	30209976
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PCF11 HMGN5 UBA1 SRRM2 UBTF CIC	4.84e-04	1049	34	6	27880917
Pubmed	Cell cycle-dependent palmitoylation of protocadherin 7 by ZDHHC5 promotes successful cytokinesis.	DARS1 UBA1 NOTCH2	5.06e-04	159	34	3	36762613
Pubmed	HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.	DARS1 ZC3H11A	5.10e-04	34	34	2	25925205
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	SRSF2 SRRM2 LARP7	5.44e-04	163	34	3	22113938
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	PCF11 REXO4 SREK1 SRSF2 SRRM2 CDK12	5.70e-04	1082	34	6	38697112
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	SCAF11 UBA1 SRSF2 MDC1	5.75e-04	394	34	4	27248496
Pubmed	The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.	SRSF2 SRRM2 SRSF8	6.04e-04	169	34	3	23084401
Pubmed	Lysine acetylation targets protein complexes and co-regulates major cellular functions.	SRSF2 SRRM2	6.38e-04	38	34	2	19608861
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NAV1 ZC3H11A ATP9A SRRM2	6.49e-04	407	34	4	12693553
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	UBA1 KLHL1 ARIH1 KAT6B CDK12	6.75e-04	730	34	5	34857952
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	LIG1 DARS1 UBA1 CIC LARP7 KIF2C	6.96e-04	1124	34	6	21900206
Pubmed	The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.	REXO4 SREK1 NKAP CDK12	7.11e-04	417	34	4	36537216
Pubmed	MITOL regulates phosphatidic acid-binding activity of RMDN3/PTPIP51.	USP43 UBA1	7.43e-04	41	34	2	34964862
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	NAV1 ZC3H11A NOTCH2	7.73e-04	184	34	3	32908313
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	DARS1 UBA1 SRSF2 CDK12 UBTF LARP7	7.95e-04	1153	34	6	29845934
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	NAV1 SRRM2 CDK12	7.97e-04	186	34	3	33637726
Pubmed	Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.	SRRM2 MDC1	8.17e-04	43	34	2	34672947
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	PCF11 LIG1 REXO4 ZC3H11A NOTCH2	8.93e-04	777	34	5	35844135
Pubmed	A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1.	SRSF2 SRSF8	8.94e-04	45	34	2	25496916
Pubmed	Dynamic protein-protein interaction wiring of the human spliceosome.	NKAP SRSF2 SRRM2	9.41e-04	197	34	3	22365833
Interaction	SRPK2 interactions	PCF11 SCAF11 REXO4 SREK1 NKAP SRSF2 SRRM2 CDK12 UBTF SRSF8 LARP7 MDC1	6.70e-10	717	33	12	int:SRPK2
Interaction	SRSF6 interactions	SCAF11 REXO4 ZC3H11A SREK1 SRSF2 SRRM2 CDK12 CIC SRSF8 LARP7	4.74e-09	503	33	10	int:SRSF6
Interaction	TERF2IP interactions	PCF11 SCAF11 ZC3H11A SREK1 SRRM2 CDK12 UBTF CIC LARP7 MDC1	1.15e-08	552	33	10	int:TERF2IP
Interaction	SRSF4 interactions	SCAF11 REXO4 SREK1 SRSF2 SRRM2 CDK12 SRSF8 LARP7	2.21e-08	300	33	8	int:SRSF4
Interaction	SRSF3 interactions	SCAF11 ZC3H11A SREK1 SRSF2 SRRM2 CDK12 CIC SRSF8 LARP7	1.09e-07	522	33	9	int:SRSF3
Interaction	SMC5 interactions	PCF11 SCAF11 REXO4 ZC3H11A SREK1 SRSF2 SRRM2 CDK12 UBTF CIC MDC1	3.00e-07	1000	33	11	int:SMC5
Interaction	MEN1 interactions	PCF11 DARS1 SCAF11 REXO4 ZC3H11A SREK1 SRSF2 KAT6B SRRM2 UBTF MDC1	4.00e-07	1029	33	11	int:MEN1
Interaction	DOT1L interactions	PCF11 DARS1 SCAF11 REXO4 ZC3H11A SRSF2 SRRM2 UBTF LARP7 MDC1	4.01e-07	807	33	10	int:DOT1L
Interaction	SNRPC interactions	SCAF11 ZC3H11A SREK1 NKAP SRRM2 CDK12 SRSF8 LARP7	4.17e-07	440	33	8	int:SNRPC
Interaction	U2AF2 interactions	PCF11 LIG1 DARS1 SCAF11 UBA1 SRSF2 SRRM2 CIC SRSF8	6.98e-07	651	33	9	int:U2AF2
Interaction	SRSF5 interactions	SCAF11 REXO4 SREK1 SRSF2 SRRM2 CDK12 SRSF8 LARP7	7.31e-07	474	33	8	int:SRSF5
Interaction	BARD1 interactions	HMGN5 SCAF11 SRSF2 SRRM2 CDK12 LARP7 MDC1	7.60e-07	323	33	7	int:BARD1
Interaction	DDX23 interactions	SCAF11 REXO4 SREK1 NKAP SRRM2 CDK12 UBTF LARP7	8.04e-07	480	33	8	int:DDX23
Interaction	SNRPA interactions	PCF11 SCAF11 ZC3H11A NKAP SRSF2 SRRM2 SRSF8 LARP7	8.29e-07	482	33	8	int:SNRPA
Interaction	POLD1 interactions	USP43 LIG1 NKAP ARIH1 SRRM2 CIC MDC1	1.01e-06	337	33	7	int:POLD1
Interaction	NR2C2 interactions	HMGN5 LIG1 DARS1 SREK1 NKAP SRSF2 SRRM2 CIC SRSF8 NOTCH2 LARP7 KIF2C	1.11e-06	1403	33	12	int:NR2C2
Interaction	OBSL1 interactions	TSGA10 UBA1 ZC3H11A SRSF2 ARIH1 SRRM2 UBTF NOTCH2 LARP7 MDC1	1.11e-06	902	33	10	int:OBSL1
Interaction	XRCC6 interactions	PCF11 SCAF11 UBA1 REXO4 ZC3H11A SRRM2 CDK12 CIC LARP7 MDC1	1.44e-06	928	33	10	int:XRCC6
Interaction	PAXIP1 interactions	SRSF2 SRRM2 CDK12 CIC LARP7 MDC1 KIF2C	1.54e-06	359	33	7	int:PAXIP1
Interaction	CSNK2A1 interactions	LIG1 SREK1 NKAP SRSF2 SRRM2 CDK12 UBTF CIC LARP7 MDC1	1.88e-06	956	33	10	int:CSNK2A1
Interaction	YWHAG interactions	USP43 NAV1 SCAF11 UBA1 NKAP SRRM2 CDK12 CIC SRSF8 NOTCH2 KIF2C	2.68e-06	1248	33	11	int:YWHAG
Interaction	SRSF1 interactions	SCAF11 REXO4 SREK1 SRSF2 SRRM2 CDK12 LARP7 MDC1	2.90e-06	570	33	8	int:SRSF1
Interaction	IFI27L1 interactions	PCF11 SCAF11 SREK1 CDK12	3.76e-06	65	33	4	int:IFI27L1
Interaction	SUMO2 interactions	DARS1 SCAF11 UBA1 ZC3H11A SRRM2 CIC MDC1 KIF2C	3.79e-06	591	33	8	int:SUMO2
Interaction	RBM39 interactions	UBA1 ZC3H11A SREK1 NKAP SRSF2 SRRM2 CDK12 CIC LARP7 MDC1	4.07e-06	1042	33	10	int:RBM39
Interaction	NUP43 interactions	REXO4 SREK1 NKAP SRRM2 CDK12 UBTF LARP7 MDC1	5.72e-06	625	33	8	int:NUP43
Interaction	NKAPD1 interactions	ZC3H11A NKAP SRRM2 UBTF SRSF8	6.06e-06	161	33	5	int:NKAPD1
Interaction	SNRNP40 interactions	SCAF11 REXO4 SREK1 SRRM2 CDK12 UBTF LARP7 MDC1	6.58e-06	637	33	8	int:SNRNP40
Interaction	SRSF2 interactions	SCAF11 SREK1 SRSF2 CDK12 SRSF8 LARP7	6.73e-06	290	33	6	int:SRSF2
Interaction	DHX8 interactions	PCF11 SCAF11 ZC3H11A NKAP SRRM2 CDK12	7.00e-06	292	33	6	int:DHX8
Interaction	CBX3 interactions	HMGN5 LIG1 REXO4 SRRM2 CDK12 UBTF CIC MDC1	7.29e-06	646	33	8	int:CBX3
Interaction	SRPK1 interactions	SCAF11 SREK1 NKAP SRSF2 SRRM2 SRSF8 LARP7	9.98e-06	477	33	7	int:SRPK1
Interaction	SRPK3 interactions	SCAF11 REXO4 SREK1 SRSF2 SRRM2	1.35e-05	190	33	5	int:SRPK3
Interaction	MDK interactions	NKAP SRRM2 UBTF NOTCH2	1.44e-05	91	33	4	int:MDK
Interaction	SNRPB interactions	SCAF11 ZC3H11A NKAP SRRM2 CIC LARP7 MDC1	1.68e-05	517	33	7	int:SNRPB
Interaction	CPSF6 interactions	PCF11 SCAF11 ZC3H11A NKAP SRRM2 LARP7 MDC1	1.88e-05	526	33	7	int:CPSF6
Interaction	SRSF8 interactions	ZC3H11A SREK1 SRSF2 SRSF8	1.93e-05	98	33	4	int:SRSF8
Interaction	HECTD1 interactions	DARS1 SCAF11 REXO4 ZC3H11A NKAP CDK12 UBTF LARP7 KIF2C	2.03e-05	984	33	9	int:HECTD1
Interaction	SNRNP70 interactions	SCAF11 ZC3H11A SREK1 NKAP SRSF2 SRRM2 CDK12 SRSF8 LARP7	2.03e-05	984	33	9	int:SNRNP70
Interaction	SIRT7 interactions	SCAF11 REXO4 ZC3H11A SRSF2 SRRM2 UBTF LARP7 MDC1	2.03e-05	744	33	8	int:SIRT7
Interaction	LUC7L2 interactions	SCAF11 SREK1 NKAP SRRM2 SRSF8 LARP7	2.06e-05	353	33	6	int:LUC7L2
Interaction	ZBTB39 interactions	TSGA10 CIC NOTCH2	2.11e-05	33	33	3	int:ZBTB39
Interaction	PLRG1 interactions	PCF11 SRSF2 SRRM2 LARP7 MDC1	2.51e-05	216	33	5	int:PLRG1
Interaction	KLHL20 interactions	HMGN5 ZC3H11A SRSF2 UBTF MDC1	2.51e-05	216	33	5	int:KLHL20
Interaction	LYAR interactions	REXO4 NKAP SRRM2 UBTF LARP7 MDC1	2.80e-05	373	33	6	int:LYAR
Interaction	PURG interactions	REXO4 ZC3H11A SREK1 CDK12 LARP7	2.92e-05	223	33	5	int:PURG
Interaction	ZNF668 interactions	REXO4 SREK1 NOTCH2 LARP7 KIF2C	3.12e-05	226	33	5	int:ZNF668
Interaction	PARP1 interactions	HMGN5 LIG1 SCAF11 UBA1 REXO4 SREK1 SRSF2 UBTF CIC LARP7	3.15e-05	1316	33	10	int:PARP1
Interaction	U2AF1 interactions	SCAF11 NKAP SRSF2 SRRM2 LARP7	4.07e-05	239	33	5	int:U2AF1
Interaction	ZNF646 interactions	REXO4 CIC NOTCH2	4.40e-05	42	33	3	int:ZNF646
Interaction	CDC5L interactions	SREK1 SRSF2 SRRM2 UBTF CIC LARP7 MDC1 KIF2C	5.48e-05	855	33	8	int:CDC5L
Interaction	FGFBP1 interactions	REXO4 SREK1 CDK12 UBTF LARP7	5.75e-05	257	33	5	int:FGFBP1
Interaction	RNPS1 interactions	ZC3H11A SREK1 NKAP SRSF2 SRRM2 CDK12	5.80e-05	425	33	6	int:RNPS1
Interaction	HNRNPC interactions	ZC3H11A SREK1 SRRM2 CIC SRSF8 LARP7 MDC1	6.18e-05	634	33	7	int:HNRNPC
Interaction	RPS19 interactions	SCAF11 REXO4 SREK1 SRRM2 CIC SRSF8 LARP7	6.49e-05	639	33	7	int:RPS19
Interaction	ZC3H18 interactions	DARS1 REXO4 ZC3H11A NKAP SRSF2 SRRM2 CDK12 SRSF8	6.55e-05	877	33	8	int:ZC3H18
Interaction	CEBPB interactions	TSGA10 DARS1 UBA1 ZC3H11A NKAP SRSF2 SRRM2 UBTF CIC KIF2C	6.91e-05	1443	33	10	int:CEBPB
Interaction	EED interactions	HMGN5 LIG1 DARS1 UBA1 ZC3H11A SRSF2 SRRM2 SRSF8 MDC1 KIF2C	6.99e-05	1445	33	10	int:EED
Interaction	EFTUD2 interactions	NAV1 DARS1 SCAF11 UBA1 SREK1 SRSF2 SRRM2 CIC LARP7 MDC1	7.16e-05	1449	33	10	int:EFTUD2
Interaction	CIT interactions	DARS1 SCAF11 UBA1 SREK1 SRSF2 SRRM2 UBTF SRSF8 MDC1 KIF2C	7.20e-05	1450	33	10	int:CIT
Interaction	THRAP3 interactions	SREK1 CDK12 CIC SRSF8 LARP7 MDC1	7.30e-05	443	33	6	int:THRAP3
Interaction	ZNF189 interactions	REXO4 CIC NOTCH2	7.90e-05	51	33	3	int:ZNF189
Interaction	ZBTB2 interactions	LIG1 SRSF2 UBTF SRSF8 LARP7 MDC1	7.96e-05	450	33	6	int:ZBTB2
Interaction	RAD18 interactions	DARS1 SCAF11 NKAP SRRM2 CDK12 SRSF8	8.67e-05	457	33	6	int:RAD18
Interaction	EIF3H interactions	ARIH1 SRRM2 CDK12 CIC LARP7	8.91e-05	282	33	5	int:EIF3H
Interaction	RBMX interactions	LIG1 SREK1 SRSF2 SRRM2 CIC LARP7	9.09e-05	461	33	6	int:RBMX
Interaction	IFI6 interactions	SCAF11 SREK1 CDK12	9.37e-05	54	33	3	int:IFI6
Interaction	MRE11 interactions	PCF11 HMGN5 LIG1 LARP7 MDC1	9.68e-05	287	33	5	int:MRE11
Interaction	SSRP1 interactions	PCF11 SCAF11 ZC3H11A SREK1 SRRM2 CIC LARP7	1.00e-04	685	33	7	int:SSRP1
Interaction	HNRNPUL2 interactions	ZC3H11A SRRM2 SRSF8 LARP7 MDC1	1.03e-04	291	33	5	int:HNRNPUL2
Interaction	ZNF768 interactions	REXO4 NOTCH2 LARP7 MDC1	1.05e-04	151	33	4	int:ZNF768
Interaction	CHD4 interactions	USP43 SCAF11 REXO4 SRRM2 UBTF CIC LARP7 MDC1	1.05e-04	938	33	8	int:CHD4
Interaction	ACTC1 interactions	DARS1 UBA1 SRRM2 CDK12 CIC LARP7 MDC1	1.09e-04	694	33	7	int:ACTC1
Interaction	AURKA interactions	LIG1 UBA1 UBTF CIC LARP7 MDC1 KIF2C	1.11e-04	696	33	7	int:AURKA
Interaction	TOP1 interactions	PCF11 LIG1 SCAF11 ZC3H11A ATP9A SRRM2 LARP7	1.11e-04	696	33	7	int:TOP1
Interaction	DDB1 interactions	HMGN5 LIG1 UBA1 ARIH1 CDK12 CIC LARP7	1.12e-04	697	33	7	int:DDB1
Interaction	SLU7 interactions	ZC3H11A SRSF2 SRRM2 CDK12	1.19e-04	156	33	4	int:SLU7
Interaction	POLR1G interactions	LIG1 REXO4 SRRM2 UBTF CIC LARP7	1.26e-04	489	33	6	int:POLR1G
Interaction	CEBPA interactions	PCF11 LIG1 DARS1 UBA1 ZC3H11A SRRM2 UBTF CIC KIF2C	1.27e-04	1245	33	9	int:CEBPA
Interaction	ZBTB24 interactions	TSGA10 REXO4 CIC NOTCH2	1.28e-04	159	33	4	int:ZBTB24
Interaction	BRCA1 interactions	HMGN5 DARS1 UBA1 ZC3H11A ARIH1 UBTF LARP7 MDC1 KIF2C	1.30e-04	1249	33	9	int:BRCA1
Interaction	BRD3 interactions	SREK1 NKAP SRRM2 UBTF LARP7 MDC1	1.33e-04	494	33	6	int:BRD3
Interaction	RPL36 interactions	HMGN5 DARS1 REXO4 SREK1 CDK12 LARP7	1.48e-04	504	33	6	int:RPL36
Interaction	ATF7 interactions	PCF11 ARIH1 CIC	1.49e-04	63	33	3	int:ATF7
Interaction	KAT6A interactions	HMGN5 REXO4 SREK1 NKAP KAT6B CDK12	1.58e-04	510	33	6	int:KAT6A
Interaction	ZNF623 interactions	ARIH1 NOTCH2	1.70e-04	12	33	2	int:ZNF623
Interaction	SNW1 interactions	PCF11 UBA1 SRSF2 SRRM2 CDK12 CIC KIF2C	1.72e-04	747	33	7	int:SNW1
Interaction	DYRK2 interactions	NKAP SRRM2 NOTCH2 LARP7	1.77e-04	173	33	4	int:DYRK2
Interaction	SPEN interactions	SRSF2 SRRM2 CDK12 NOTCH2	1.97e-04	178	33	4	int:SPEN
Interaction	PRPF6 interactions	SRSF2 SRRM2 CIC SRSF8 LARP7	2.02e-04	336	33	5	int:PRPF6
Interaction	POLR2A interactions	PCF11 HMGN5 SRSF2 CDK12 CIC MDC1	2.07e-04	536	33	6	int:POLR2A
Interaction	SNRPD1 interactions	SREK1 SRSF2 SRRM2 CIC LARP7	2.35e-04	347	33	5	int:SNRPD1
Interaction	MAGEB2 interactions	REXO4 SREK1 CDK12 UBTF SRSF8	2.41e-04	349	33	5	int:MAGEB2
Interaction	MYCN interactions	SCAF11 REXO4 ZC3H11A NKAP SRSF2 SRRM2 CDK12 UBTF LARP7	2.66e-04	1373	33	9	int:MYCN
Interaction	MIR9-2 interactions	DARS1 ZC3H11A LARP7	2.69e-04	77	33	3	int:MIR9-2
Interaction	SFPQ interactions	PCF11 SREK1 SRRM2 CIC LARP7 MDC1	2.70e-04	563	33	6	int:SFPQ
Interaction	CLK2 interactions	ZC3H11A SRRM2 SRSF8 LARP7	2.79e-04	195	33	4	int:CLK2
Interaction	BRPF1 interactions	HMGN5 KAT6B KIF2C	2.80e-04	78	33	3	int:BRPF1
Interaction	SF3B1 interactions	REXO4 ZC3H11A SRSF2 SRRM2 CIC LARP7	2.91e-04	571	33	6	int:SF3B1
Interaction	SRP14 interactions	REXO4 ARIH1 SRRM2 CIC LARP7	3.00e-04	366	33	5	int:SRP14
Cytoband	5q12.3	SREK1 RGS7BP	8.08e-05	18	34	2	5q12.3
Cytoband	Ensembl 112 genes in cytogenetic band chr5q12	SREK1 RGS7BP	1.11e-03	66	34	2	chr5q12
Cytoband	Ensembl 112 genes in cytogenetic band chr1q32	NAV1 ZC3H11A LAD1	1.29e-03	290	34	3	chr1q32
GeneFamily	RNA binding motif containing\|Serine and arginine rich splicing factors	SRSF2 SRSF8	7.62e-05	12	20	2	737
GeneFamily	RNA binding motif containing	SREK1 SRSF2 LARP7	1.59e-03	213	20	3	725
GeneFamily	Ankyrin repeat domain containing	CLIP3 NOTCH2	2.89e-02	242	20	2	403
Coexpression	GSE17721_LPS_VS_POLYIC_1H_BMDC_DN	USP43 SCAF11 REXO4 SREK1 UBTF	5.58e-06	199	34	5	M3800
Coexpression	GSE22432_MULTIPOTENT_PROGENITOR_VS_CDC_DN	LIG1 DARS1 UBTF LARP7 MDC1	5.72e-06	200	34	5	M7819
Coexpression	DAZARD_RESPONSE_TO_UV_NHEK_DN	PCF11 SCAF11 KAT6B LARP7 MDC1	4.03e-05	300	34	5	M8702
Coexpression	TABULA_MURIS_SENIS_LIMB_MUSCLE_SCHWANN_CELL_AGEING	SCAF11 SRRM2	7.30e-05	10	34	2	MM3742
Coexpression	GCNP_SHH_UP_LATE.V1_UP	LIG1 ARIH1 LARP7 KIF2C	8.68e-05	181	34	4	M2641
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	PCF11 DARS1 SCAF11 ZC3H11A SRSF2 ARIH1 KAT6B UBTF NOTCH2	8.78e-05	1492	34	9	M40023
Coexpression	GSE9960_GRAM_NEG_VS_GRAM_NEG_AND_POS_SEPSIS_PBMC_UP	KLHL1 LARP7 LAD1 SCN5A	1.07e-04	191	34	4	M7130
Coexpression	GSE22432_CONVENTIONAL_CDC_VS_PLASMACYTOID_PDC_UP	LIG1 DARS1 UBTF MDC1	1.25e-04	199	34	4	M7811
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_2500_k-means-cluster#1	PCF11 HMGN5 CLIP3 SCAF11 CDK12 MDC1 KIF2C	6.37e-06	469	33	7	Facebase_RNAseq_e8.5_Floor Plate_2500_K1
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_1000_k-means-cluster#1	HMGN5 CLIP3 CDK12 LARP7 MDC1	4.66e-05	259	33	5	Facebase_RNAseq_e8.5_Floor Plate_1000_K1
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3	TSGA10 HMGN5 LIG1 CLIP3 SCAF11 SREK1 LARP7 MDC1 KIF2C	9.17e-05	1257	33	9	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
ToppCell	LPS-IL1RA-Endothelial-Epi-like-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HMGN5 KLHL1 UBTF KIF2C	2.63e-06	127	34	4	6b24630978eb0772b4cd3bf59e5bc4390be47619
ToppCell	droplet-Bladder-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCF11 SCAF11 SRRM2 CDK12	1.22e-05	187	34	4	663991a8afe652e92363b64bcbd68c14d0307f0e
ToppCell	H1299-infected\|H1299 / Cell line, Condition and Strain	SREK1 SRSF2 SRRM2 KIF2C	1.35e-05	192	34	4	9cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	HMGN5 SREK1 SRRM2 LARP7	1.49e-05	197	34	4	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	DARS1 SCAF11 ZC3H11A NKAP	1.52e-05	198	34	4	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	facs-Heart-RA-24m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LMOD2 LAD1 SCN5A	2.30e-04	157	34	3	9021900d9b1a71210c9c414a9d165eaf399eb607
ToppCell	facs-Heart-RA-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LMOD2 LAD1 SCN5A	2.30e-04	157	34	3	c8c627ca181856cd31dba4cf073c2be659a49dc1
ToppCell	10x5'v1-week_17-19-Hematopoietic-HSC/MPP_and_pro-HSC/MPP\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CLIP3 ATP9A SCN5A	2.48e-04	161	34	3	aee74a2e7a8acd2950341963f1c04b59c7862183
ToppCell	LPS-antiTNF-Endothelial-Mes-Like-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SREK1 CIC SRSF8	2.71e-04	166	34	3	3b750d4023a0a09d86113aae5a97d84391f7b482
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LMOD2 LAD1 SCN5A	3.01e-04	172	34	3	bd468a7ea6ec832dcf6a816a1e0c03fa0f176dad
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LMOD2 LAD1 SCN5A	3.01e-04	172	34	3	ee8ce9e8c9a6d3ee2be113f77743958005f4b3f0
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	HMGN5 ATP9A KAT6B	3.27e-04	177	34	3	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCAF11 SRRM2 CDK12	3.33e-04	178	34	3	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	Bac-SEP-Lymphocyte-T_NK-T_NK_proliferative\|Bac-SEP / Disease, Lineage and Cell Type	USP43 LIG1 KIF2C	3.67e-04	184	34	3	848d05afd5a2ef61fb8a09c0f5fa2a56fd5c160b
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Lgr5-_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMGN5 LIG1 SRRM2	3.79e-04	186	34	3	15ab6666748a641226e42e6ca6eeaf186a501c95
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-epithelial_cell_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMGN5 LIG1 SRRM2	3.79e-04	186	34	3	4ed1b97e2552f3c4134f25665d7513498ffac16c
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NAV1 SREK1 KLHL1	3.79e-04	186	34	3	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	droplet-Tongue-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCAF11 SRRM2 CDK12	3.91e-04	188	34	3	d62cc37e86b7b186e53aeb7f421c4e5ee28f23bd
ToppCell	facs-Heart-RA-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LMOD2 LAD1 SCN5A	3.97e-04	189	34	3	e758b264c0a47127e33e66c395cf5a3224c7305b
ToppCell	facs-Heart-RA-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LMOD2 LAD1 SCN5A	3.97e-04	189	34	3	b98f60875b1a12b2ec9dc91889298ae57f98602f
ToppCell	COVID-19-Heart\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NAV1 LMOD2 SCN5A	4.03e-04	190	34	3	918ad5037881212008f9f69d5df5da91fd01422c
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	SCAF11 SREK1 SRRM2	4.15e-04	192	34	3	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	SCAF11 SREK1 SRRM2	4.22e-04	193	34	3	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCAF11 RGS7BP SRRM2	4.22e-04	193	34	3	06b65110db974f4ef90d3511ff34428976a52c9c
ToppCell	facs-Brain_Myeloid-Hippocampus-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCAF11 RGS7BP SRRM2	4.22e-04	193	34	3	a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCell	droplet-Tongue-nan-24m-Epithelial-proliferating\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMGN5 LIG1 KIF2C	4.22e-04	193	34	3	f20b90e3f3f5c9a1ae51c5ebe6d3adb954a142f2
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCAF11 RGS7BP SRRM2	4.22e-04	193	34	3	9c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCAF11 RGS7BP SRRM2	4.22e-04	193	34	3	b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCell	human_hepatoblastoma-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	LIG1 MDC1 KIF2C	4.22e-04	193	34	3	4b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCell	Mild_COVID-19-Myeloid-cDC\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	NAV1 RGL1 LAD1	4.35e-04	195	34	3	24149bb6933135b1a0a5c7f505914942b3782c3a
ToppCell	facs-Skin-Skin_Anagen-18m-Epithelial\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SRSF2 SRRM2 NOTCH2	4.35e-04	195	34	3	2c03d1a2f208b6737311458a4bd8f2e4444de29a
ToppCell	BAL-Mild-Myeloid-cDC-cDC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NAV1 RGL1 LAD1	4.35e-04	195	34	3	66e5fd9f3208a06d617c5e994822bf57dceae7e2
ToppCell	BAL-Mild-Myeloid-cDC\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NAV1 RGL1 LAD1	4.35e-04	195	34	3	9e5cf33b5dd455efa464a63d7116786c0786aefd
ToppCell	BAL-Mild-Myeloid-cDC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	NAV1 RGL1 LAD1	4.35e-04	195	34	3	6ba23e19801305e071b0e4aaf1ee6f53f3b027d3
ToppCell	facs-Skin-Skin_Anagen\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SRSF2 SRRM2 NOTCH2	4.35e-04	195	34	3	ffd87cc7ae9b141bf48e072ea1a1420794499790
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMGN5 LIG1 KIF2C	4.35e-04	195	34	3	7ae732f100e9a3c6062be5b877efa1ec9d5b3958
ToppCell	facs-Skin-Skin_Anagen-18m\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SRSF2 SRRM2 NOTCH2	4.35e-04	195	34	3	0d37dd66a8d60fc9cda3d6e3c4fbe67e577b890e
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMGN5 LIG1 KIF2C	4.35e-04	195	34	3	e9c7eb0b1a2d58f69b4e839665101948bd4527b8
ToppCell	BAL-Mild-Myeloid-cDC-cDC\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	NAV1 RGL1 LAD1	4.35e-04	195	34	3	7209babdff96c93cd52cfe5d5cfd7e3c0274d8dd
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMGN5 LIG1 KIF2C	4.35e-04	195	34	3	043e2f19d95e94cd5219e2c415f322ed340aa80f
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMGN5 LIG1 KIF2C	4.41e-04	196	34	3	5ddd314d3def3776dc7da83778d41c6436ca51ac
ToppCell	PBMC-Control-cDC_3\|Control / Compartment, Disease Groups and Clusters	NAV1 ZC3H11A NOTCH2	4.41e-04	196	34	3	09d197b321ff9f13c0672ea059c850845b0dbbd5
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMGN5 LIG1 KIF2C	4.48e-04	197	34	3	9b2c67de46bd59bf56c81a0d10b84cf4a041c120
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMGN5 LIG1 KIF2C	4.48e-04	197	34	3	f84f0ddf51208764ab56408d97035bbff562e59d
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	SCAF11 SREK1 SRRM2	4.48e-04	197	34	3	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	10x3'2.3-week_17-19\|World / cell types per 3 fetal stages;per 3',per 5'	PCF11 ARIH1 SRRM2	4.48e-04	197	34	3	f5cfad0b42d0f817e22cc78b9bfb2b4b7e4330ed
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMGN5 LIG1 KIF2C	4.48e-04	197	34	3	a0d463825b62de49466f9fa563405dda4387cfff
ToppCell	facs-Diaphragm-Limb_Muscle-3m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCF11 SRSF2 NOTCH2	4.48e-04	197	34	3	b0e2ea81308bce289cb7cbea0e27de1d01afeed2
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW13-Stem_cells\|GW13 / Sample Type, Dataset, Time_group, and Cell type.	LIG1 MDC1 KIF2C	4.61e-04	199	34	3	fd1d1b95e01719e3d0a17d9d1f29717a47209d32
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	SCAF11 ZC3H11A LARP7	4.61e-04	199	34	3	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	Non-neuronal\|World / Primary Cells by Cluster	HMGN5 NOTCH2 KIF2C	4.61e-04	199	34	3	165d9de6cedc79e13bb6fa244e8898a5dacc54ff
ToppCell	megakaryocytic-CD34+_Megakaryoblast\|megakaryocytic / Lineage and Cell class	DARS1 SCAF11 SRRM2	4.61e-04	199	34	3	99a65887d3c8a2cde26693dd74404b101bba9d58
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW13-Stem_cells-Stem_cells\|GW13 / Sample Type, Dataset, Time_group, and Cell type.	LIG1 MDC1 KIF2C	4.61e-04	199	34	3	91882af9dc7265c9b419f4415cbcf656087a2ab3
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NAV1 CLIP3 KLHL1	4.61e-04	199	34	3	333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NAV1 CLIP3 KLHL1	4.61e-04	199	34	3	e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell	Sigmoid-Dendritic_cell-cycling_DCs\|Dendritic_cell / Region, Cell class and subclass	LIG1 RGL1 KIF2C	4.68e-04	200	34	3	372fe9018481a4e9ac6ab3af43705a48238c4376
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW13-Stem_cells\|GW13 / Sample Type, Dataset, Time_group, and Cell type.	LIG1 MDC1 KIF2C	4.68e-04	200	34	3	d933978b55fefe52cad599b36f6b47a0c7f71f96
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Stem_cells-Neuroepithelial_cell\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	HMGN5 LIG1 KIF2C	4.68e-04	200	34	3	c88d8e67647c90d1fa2569516865a9fd766eaf1c
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NAV1 CLIP3 KLHL1	4.68e-04	200	34	3	ad777683adeb2ce45ade570386235e311fa7ea2d
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Stem_cells-Neuroepithelial_cell\|3m / Sample Type, Dataset, Time_group, and Cell type.	HMGN5 LIG1 KIF2C	4.68e-04	200	34	3	2938a029fa0478be561574ace91f95c4a528b2d4
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW12-Stem_cells\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	HMGN5 CIC NOTCH2	4.68e-04	200	34	3	4a57d6ba1531ce4e263daccd5de487977e6a1fdd
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW12-Stem_cells-Stem_cells\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	HMGN5 CIC NOTCH2	4.68e-04	200	34	3	b706526b9c3485889a31253a1ffd017ad3f3fddc
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Stem_cells\|3m / Sample Type, Dataset, Time_group, and Cell type.	HMGN5 LIG1 KIF2C	4.68e-04	200	34	3	cfe017b4a4d604a553d0a3df9659687f38e9a7af
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SCAF11 SREK1 SRRM2	4.68e-04	200	34	3	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW13-Stem_cells-Neuroepithelial_cell\|GW13 / Sample Type, Dataset, Time_group, and Cell type.	LIG1 MDC1 KIF2C	4.68e-04	200	34	3	3d932765c31aef1f80a118d51e8e66c50a758dbb
ToppCell	TCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma-Intrahepatic\|TCGA-Bile_Duct / Sample_Type by Project: Shred V9	CIC NOTCH2 LAD1	4.68e-04	200	34	3	1fa8422fd820d21e285a7e7c4c6fbd8b7277d2af
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Stem_cells\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	HMGN5 LIG1 KIF2C	4.68e-04	200	34	3	28935053cd6918cd2e9f3e7691f8522216585cb6
ToppCell	Sepsis-Bac-SEP-Lymphocyte-T/NK-T/NK_proliferative\|Bac-SEP / Disease, condition lineage and cell class	USP43 LIG1 KIF2C	4.68e-04	200	34	3	a09b4e07b273880e94032b939ab191caaf6d656e
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A	SCAF11 SREK1 KAT6B SRRM2 UBTF LARP7	2.60e-07	181	34	6	7077_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 ATP9A KAT6B SRRM2 UBTF	4.82e-06	168	34	5	3868_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF LAD1	4.82e-06	168	34	5	6820_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 ATP9A KAT6B SRRM2 UBTF	5.41e-06	172	34	5	2794_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 CDK12 UBTF	5.56e-06	173	34	5	5336_DN
Drug	Trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A	SCAF11 SREK1 KAT6B CDK12 UBTF	5.72e-06	174	34	5	1659_DN
Drug	HC toxin from Helminthosporium carbonum; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	SREK1 KAT6B SRRM2 CDK12 UBTF	5.72e-06	174	34	5	909_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF LARP7	5.88e-06	175	34	5	7387_DN
Drug	Trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A_EA	SREK1 KAT6B SRRM2 CDK12 UBTF	5.88e-06	175	34	5	1014_DN
Drug	Trichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 CDK12 UBTF	6.05e-06	176	34	5	6932_DN
Drug	SAHA; Down 200; 10uM; MCF7; HT_HG-U133A	SREK1 ATP9A KAT6B SRRM2 UBTF	6.22e-06	177	34	5	1645_DN
Drug	Trichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SCAF11 SREK1 ATP9A KAT6B UBTF	6.22e-06	177	34	5	6972_DN
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A	SCAF11 KAT6B SRRM2 UBTF LARP7	7.92e-06	186	34	5	6874_DN
Drug	MS-275; Down 200; 10uM; PC3; HT_HG-U133A	KAT6B SRRM2 CDK12 UBTF KIF2C	8.56e-06	189	34	5	7074_DN
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A	SREK1 KAT6B UBTF LARP7 KIF2C	9.00e-06	191	34	5	7503_DN
Drug	trichostatin A; Down 200; 0.1uM; ssMCF7; HG-U133A	DARS1 SREK1 ATP9A KAT6B UBTF	9.47e-06	193	34	5	413_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	9.47e-05	161	34	4	4768_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	9.93e-05	163	34	4	7453_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.02e-04	164	34	4	4388_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B UBTF LAD1	1.04e-04	165	34	4	5625_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.04e-04	165	34	4	6085_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.04e-04	165	34	4	2835_DN
Drug	SAHA; Down 200; 10uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.09e-04	167	34	4	5217_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.09e-04	167	34	4	3979_DN
Drug	Trichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.14e-04	169	34	4	5572_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.14e-04	169	34	4	6064_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	KAT6B SRRM2 UBTF LARP7	1.17e-04	170	34	4	3791_DN
Drug	Trichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	SREK1 KAT6B SRRM2 UBTF	1.17e-04	170	34	4	1050_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.22e-04	172	34	4	3428_DN
Drug	Trichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.22e-04	172	34	4	5209_DN
Drug	Trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A	SREK1 KAT6B UBTF LAD1	1.22e-04	172	34	4	6993_DN
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A	SCAF11 KAT6B SRRM2 UBTF	1.22e-04	172	34	4	7073_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.25e-04	173	34	4	2881_DN
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A	KAT6B SRRM2 UBTF LARP7	1.28e-04	174	34	4	7105_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	KAT6B SRRM2 UBTF LARP7	1.28e-04	174	34	4	3993_DN
Drug	AC1NRA5C	SREK1 SRSF2 SRRM2 CDK12	1.28e-04	174	34	4	CID005287709
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.28e-04	174	34	4	6493_DN
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A	KAT6B SRRM2 UBTF LARP7	1.28e-04	174	34	4	5940_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	KAT6B SRRM2 UBTF LARP7	1.28e-04	174	34	4	5065_DN
Drug	mexiletine	NAV1 ARIH1 SCN5A	1.31e-04	66	34	3	CID000004178
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	KAT6B SRRM2 UBTF LARP7	1.31e-04	175	34	4	3787_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B CDK12 UBTF	1.31e-04	175	34	4	7236_DN
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.31e-04	175	34	4	6891_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.34e-04	176	34	4	2639_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.34e-04	176	34	4	1535_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.34e-04	176	34	4	3312_DN
Drug	SAHA; Down 200; 10uM; MCF7; HT_HG-U133A	SREK1 KAT6B UBTF LAD1	1.34e-04	176	34	4	6980_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.34e-04	176	34	4	6784_DN
Drug	trichostatin A ; Down 200; 1uM; MCF7; HT_HG-U133A_EA	SREK1 KAT6B CDK12 UBTF	1.36e-04	177	34	4	873_DN
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.36e-04	177	34	4	7550_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.36e-04	177	34	4	3227_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 ATP9A KAT6B UBTF	1.36e-04	177	34	4	5308_DN
Drug	Trichostatin A, Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	KAT6B SRRM2 UBTF LARP7	1.39e-04	178	34	4	4436_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.39e-04	178	34	4	4710_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.39e-04	178	34	4	1471_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.39e-04	178	34	4	7245_DN
Drug	Trichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	SREK1 KAT6B SRRM2 UBTF	1.39e-04	178	34	4	992_DN
Drug	SAHA; Down 200; 10uM; PC3; HT_HG-U133A	KAT6B SRRM2 UBTF LARP7	1.39e-04	178	34	4	4444_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.39e-04	178	34	4	6276_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	KAT6B SRRM2 UBTF LARP7	1.39e-04	178	34	4	5086_DN
Drug	trichostatin A; Down 200; 0.1uM; MCF7; HG-U133A	SREK1 ATP9A KAT6B UBTF	1.42e-04	179	34	4	331_DN
Drug	Captopril [62571-86-2]; Down 200; 17.2uM; PC3; HT_HG-U133A	SCAF11 KAT6B SRRM2 UBTF	1.42e-04	179	34	4	4585_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.46e-04	180	34	4	6454_DN
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A	SCAF11 KAT6B SRRM2 UBTF	1.46e-04	180	34	4	5981_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.46e-04	180	34	4	4821_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 KAT6B SRRM2 UBTF	1.49e-04	181	34	4	3643_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SREK1 ATP9A KAT6B SRRM2	1.55e-04	183	34	4	3510_DN
Drug	Rifabutin [72559-06-9]; Down 200; 4.8uM; PC3; HT_HG-U133A	KAT6B SRRM2 UBTF LARP7	1.55e-04	183	34	4	4527_DN
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A	KAT6B SRRM2 UBTF LAD1	1.58e-04	184	34	4	6916_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HG-U133A	PCF11 DARS1 KAT6B UBTF	1.72e-04	188	34	4	1421_DN
Drug	scriptaid; Down 200; 10uM; PC3; HT_HG-U133A	KAT6B NOTCH2 LAD1 KIF2C	1.86e-04	192	34	4	6919_DN
Drug	Tamoxifen citrate [54965-24-1]; Down 200; 7uM; HL60; HG-U133A	RGL1 KAT6B SRRM2 CDK12	1.98e-04	195	34	4	1366_DN
Drug	Tolazoline hydrochloride [59-97-2]; Down 200; 20.4uM; MCF7; HT_HG-U133A	SCAF11 KAT6B UBTF CIC	2.02e-04	196	34	4	4844_DN
Drug	Famotidine [76824-35-6]; Down 200; 11.8uM; MCF7; HT_HG-U133A	TSGA10 HMGN5 CIC NOTCH2	2.02e-04	196	34	4	5011_DN
Drug	NS-398; Down 200; 10uM; MCF7; HT_HG-U133A	LIG1 NOTCH2 LAD1 KIF2C	2.06e-04	197	34	4	6911_DN
Drug	Furazolidone [67-45-8]; Down 200; 17.8uM; HL60; HT_HG-U133A	KAT6B NOTCH2 LAD1 SCN5A	2.06e-04	197	34	4	3019_DN
Drug	Verapamyl hydrochloride [152-11-4]; Down 200; 8.2uM; PC3; HT_HG-U133A	ARIH1 SRRM2 UBTF NOTCH2	2.10e-04	198	34	4	6287_DN
Drug	5BrUTP	SRSF2 UBTF	2.25e-04	15	34	2	CID000122301
Drug	epsilon-AMP	LIG1 UBA1	4.91e-04	22	34	2	CID000161948
Drug	AP-A	ARIH1 SCN5A	5.85e-04	24	34	2	CID000188964
Drug	deoxynivalenol	LIG1 ZC3H11A SRSF2 SRRM2 LARP7	6.92e-04	481	34	5	ctd:C007262
Disease	Bladder Neoplasm	HMGN5 LIG1 NOTCH2	5.14e-04	140	33	3	C0005695
Disease	Malignant neoplasm of urinary bladder	HMGN5 LIG1 NOTCH2	5.25e-04	141	33	3	C0005684

Protein segments in the cluster

Peptide	Gene	Start	Entry
SLSRSPLPSRKSMKS	CDK12	341	Q9NYV4
PLPSRKSMKSRSRSP	CDK12	346	Q9NYV4
MSSAPNGRKKRPSRS	RGS7BP	1	Q6MZT1
TTSPKPRKSMVKRLS	RGL1	506	Q9NZL6
APPKRMRRKTELSST	KAT6B	566	Q8WYB5
PSKKSRTRQMNTRSS	ARIH1	166	Q9Y4X5
MRTPKRTRSPKTKVS	LINC02906	1	E5RJ46
KKSRRPSAKSTMPTS	NOTCH2	2101	Q04721
LKRSSPRTISFRMKP	LAD1	366	O00515
KIRTRKSSRMTPFPA	MDC1	1106	Q14676
KKMEDSSRPSTPQRS	LMOD2	506	Q6P5Q4
TPEVKPKRTSSSRKM	HMGN5	31	P82970
TSISKMKRSRPTSEG	LARP7	246	Q4G0J3
GPTLTTKVRRTMSSR	ATP9A	441	O75110
RSPKRRQRSMSPTST	PCF11	501	O94913
RQRSMSPTSTPKAGK	PCF11	506	O94913
SRMPIVTRSSTKRKQ	FAM172BP	346	A6NC97
MTQPKRTFTTVRTPK	CLIP3	506	Q96DZ5
MDSSPSGIPKRRTAR	LIG1	111	P18858
NTRGSRRKPAMTTPT	SCAF11	306	Q99590
PAPKESLRSRSTRMS	KIF2C	101	Q99661
RRSSSKSPKPSKSAR	NKAP	21	Q8N5F7
RSLPRPAKSSSMSVT	NAV1	671	Q8NEY1
SKMDRRAPVPRTKAS	REXO4	136	Q9GZR2
SKRESKSRSRSKSPP	SRSF2	196	Q01130
SPEMKKSRISSRRSR	SRRM2	746	Q9UQ35
LTRGLSRTSMKPRSS	SCN5A	511	Q14524
MPSASASRKSQEKPR	DARS1	1	P14868
SKTIKRKSSRSPSPR	SREK1	396	Q8WXA9
SSSMTRSPPRVSKRK	SRSF8	246	Q9BRL6
DPTSPKRKMRRRSSC	CIC	1406	Q96RK0
KGRSISMKAPTTSRA	USP43	791	Q70EL4
SMKTRRLSSASTGKP	ZC3H11A	751	O75152
ASPTRMPSRASLKMT	nan	16	Q9UF83
TPSMVSLKRSPSRAS	nan	456	Q9UF83
MSSSPLSKKRRVSGP	UBA1	1	P22314
MMRSRSKSPRRPSPT	TSGA10	1	Q9BZW7
MTKLRGPNPKSSRTT	UBTF	656	P17480
MQSPRTKPRKSTVGT	KLHL1	446	Q9NR64