Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	CAD PFDN4 CEP192 ASAP1 ACSL3 ARID1B PTPN14 TTC7B STXBP3 TMEM160 IK SLC12A7 GCN1 CPSF3 PPP1R12C	1.29e-06	1049	111	15	27880917
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	CAD TENT4A ZCCHC8 KIF16B ARRDC3 IK GCN1 CPSF3	7.78e-06	313	111	8	38270169
Pubmed	Gene structure, expression and chromosomal localization of murine theta class glutathione transferase mGSTT1-1.	GSTT2B GSTT2	1.01e-05	2	111	2	9854036
Pubmed	Deficiency of myostatin protects skeletal muscle cells from ischemia reperfusion injury.	ACVR2B MSTN	1.01e-05	2	111	2	34131275
Pubmed	Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight.	ACVR2B MSTN	1.01e-05	2	111	2	32900939
Pubmed	Identification and characterization of GSTT3, a third murine Theta class glutathione transferase.	GSTT2B GSTT2	1.01e-05	2	111	2	12038961
Pubmed	Linkage disequilibrium between two high-frequency deletion polymorphisms: implications for association studies involving the glutathione-S transferase (GST) genes.	GSTT2B GSTT2	1.01e-05	2	111	2	19424424
Pubmed	Mammalian class theta GST and differential susceptibility to carcinogens: a review.	GSTT2B GSTT2	1.01e-05	2	111	2	11018744
Pubmed	Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1.	GSTT2B GSTT2	1.01e-05	2	111	2	8617493
Pubmed	Characterization of a human class-Theta glutathione S-transferase with activity towards 1-menaphthyl sulphate.	GSTT2B GSTT2	1.01e-05	2	111	2	1417752
Pubmed	Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22.	GSTT2B GSTT2	1.01e-05	2	111	2	7789971
Pubmed	The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.	CAD NPEPPS ACSL3 SLC25A13 SMARCD2 GCN1 CPSF3	1.16e-05	237	111	7	29564676
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	KIF16B ZDBF2 ZBTB26 CEP192 CADPS2	1.88e-05	101	111	5	10997877
Pubmed	Mediator 1 contributes to enamel mineralization as a coactivator for Notch1 signaling and stimulates transcription of the alkaline phosphatase gene.	MED1 ALPL	3.02e-05	3	111	2	28673966
Pubmed	The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human.	GSTT2B GSTT2	3.02e-05	3	111	2	8761485
Pubmed	Regulation of muscle growth by multiple ligands signaling through activin type II receptors.	ACVR2B MSTN	3.02e-05	3	111	2	16330774
Pubmed	Cdc2-like kinase 2 suppresses hepatic fatty acid oxidation and ketogenesis through disruption of the PGC-1α and MED1 complex.	MED1 CLK2	3.02e-05	3	111	2	24458359
Pubmed	Glutathione S-transferases promote proinflammatory astrocyte-microglia communication during brain inflammation.	GSTT2B GSTT2	3.02e-05	3	111	2	30783009
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CAD ZCCHC8 NPEPPS ACSL3 SLC25A13 XRN1 IK GCN1 NNT CPSF3	4.78e-05	653	111	10	22586326
Pubmed	HACE1: A novel repressor of RAR transcriptional activity.	RARG HACE1	6.03e-05	4	111	2	19350571
Pubmed	Identification, characterization, and crystal structure of the Omega class glutathione transferases.	GSTT2B GSTT2	6.03e-05	4	111	2	10783391
Pubmed	Regulation of myostatin activity and muscle growth.	ACVR2B MSTN	6.03e-05	4	111	2	11459935
Pubmed	Myostatin, follistatin and activin type II receptors are highly expressed in adenomyosis.	ACVR2B MSTN	6.03e-05	4	111	2	26086422
Pubmed	Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in adipose tissue and skeletal muscle of obese mice.	ACVR2B MSTN	6.03e-05	4	111	2	18334608
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	CAD ZCCHC8 NOA1 KIF16B PFDN4 ZDBF2 ACSL3 VPS13D PTPN14 TMEM160 SLC25A13 SCO1 MTFR2 DDHD2 NNT	8.36e-05	1496	111	15	32877691
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	PFDN4 CEP192 DNAH7 ASAP1 MEN1 PTPN14 STXBP3 N4BP2 XRN1 GNA11 CLEC16A	9.25e-05	853	111	11	28718761
Pubmed	Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women.	ACVR2B MSTN	1.00e-04	5	111	2	22395277
Pubmed	Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex.	GSTT2B GSTT2	1.00e-04	5	111	2	9729470
Pubmed	A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs.	PIP5K1A CPSF3	1.00e-04	5	111	2	18288197
Pubmed	A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7.	ACVR2B MSTN	1.00e-04	5	111	2	18621057
Pubmed	Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria.	MED1 GSTT2B GSTT2 TAF1L	1.06e-04	76	111	4	22323595
Pubmed	Role of satellite cells versus myofibers in muscle hypertrophy induced by inhibition of the myostatin/activin signaling pathway.	ACVR2B MSTN	1.50e-04	6	111	2	22869749
Pubmed	CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs.	PIP5K1A CPSF3	1.50e-04	6	111	2	18305108
Pubmed	Latent myostatin has significant activity and this activity is controlled more efficiently by WFIKKN1 than by WFIKKN2.	ACVR2B MSTN	1.50e-04	6	111	2	23829672
Pubmed	Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis.	ACVR2B MSTN	1.50e-04	6	111	2	14517293
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	SETX APOB CEP192 ASAP1 SBNO2 MEN1 COPS7A NLGN3 ARID1B CSNK1G3 GNA11 IK	1.84e-04	1084	111	12	11544199
Pubmed	Loss of MLL Induces Epigenetic Dysregulation of Rasgrf1 to Attenuate Kras-Driven Lung Tumorigenesis.	RASGRF1 MEN1	2.10e-04	7	111	2	36098964
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	RASGRF1 MCF2 FGD4	2.46e-04	38	111	3	11756498
Pubmed	Autoregulation of neurogenesis by GDF11.	ACVR2B MSTN	2.79e-04	8	111	2	12546816
Pubmed	Myostatin directly regulates skeletal muscle fibrosis.	ACVR2B MSTN	2.79e-04	8	111	2	18453534
Pubmed	Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia.	APOB ALPL	2.79e-04	8	111	2	18496130
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CAD SETX ZCCHC8 NOA1 MED1 MEN1 RSBN1 FGD4 SLC25A13 XRN1 GNA11 IK TAF1L PPP1R12C	3.00e-04	1497	111	14	31527615
Pubmed	Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.	MED1 MEN1 COPS7A ARID1B SMARCD2 CPSF3	3.05e-04	283	111	6	28533407
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	CAD ZDBF2 EIPR1 MED1 METTL23 MEN1 RLF ACSL3 SCG3 SLC25A13 XRN1 ATP13A3 GCN1	3.21e-04	1327	111	13	32694731
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CEP192 DENND11 ASAP1 RSBN1 ARRDC3 CLEC16A LARGE1	3.41e-04	407	111	7	12693553
Pubmed	NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.	RASGRF1 MCF2 FGD4	3.56e-04	43	111	3	12376548
Pubmed	Dominant and redundant functions of TFIID involved in the regulation of hepatic genes.	APOB MED1 TAF1L	3.56e-04	43	111	3	18722179
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	CAD MED1 ARID1B PTPN14 SLC25A13 XRN1 IK GCN1	3.90e-04	549	111	8	38280479
Pubmed	Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.	NPEPPS ACSL3 STXBP3 SLC25A13 GCN1 NNT CPSF3	4.24e-04	422	111	7	27342126
Pubmed	Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner.	ARID1B SMARCD2	4.47e-04	10	111	2	12665591
Pubmed	The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.	XRN1 LSM7	4.47e-04	10	111	2	12515382
Pubmed	Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.	CAD APOB ACSL3 GCN1	4.84e-04	113	111	4	30352685
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	DOCK1 CAD MED1 XRN1 GCN1	4.90e-04	202	111	5	33005030
Pubmed	Fine genetic and comparative mapping of the deafness mutation Ames waltzer on mouse chromosome 10.	GSTT2B GSTT2	5.45e-04	11	111	2	9653653
Pubmed	Activator-Mediator binding regulates Mediator-cofactor interactions.	MED1 GCN1	5.45e-04	11	111	2	20534441
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	ENPP7 TENT4A ACSL3 KCNH6 ARID1B KCNG1 CLK2 PIP5K1A TAF1L	5.67e-04	730	111	9	34857952
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	CAD SETX ZCCHC8 ZDBF2 CEP192 COPS7A PTPN14 N4BP2	6.12e-04	588	111	8	38580884
Pubmed	Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.	CAD RLF ACSL3 NBPF15 VPS13D SLC25A13 LSM7	6.53e-04	454	111	7	33226137
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	CAD SETX ZCCHC8 MED1 ARID1B SCG3 SLC25A13 IK GCN1 LSM7 CPSF3	6.99e-04	1082	111	11	38697112
Pubmed	Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.	ASAP1 CLEC16A	7.69e-04	13	111	2	19525955
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	SETX ZCCHC8 CLK2 N4BP2 SMARCD2 MTFR2 GCN1	7.90e-04	469	111	7	27634302
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	CAD NPEPPS COPS7A FOXRED2 SLC25A13 SERPINB1 GCN1 ALPL	8.02e-04	613	111	8	22268729
Pubmed	Translational animal models of autism and neurodevelopmental disorders.	NLGN3 CADPS2	8.96e-04	14	111	2	23226954
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DOCK1 NPEPPS CEP192 EIPR1 ACVR2B SBNO2 RLF NLGN3 CLK2 TTC21B PIP5K1A CLEC16A LSM7	9.40e-04	1489	111	13	28611215
Pubmed	Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).	RASGRF1 MCF2 FGD4	9.48e-04	60	111	3	12787561
Pubmed	The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression.	ARID1B SMARCD2	1.03e-03	15	111	2	11263494
Pubmed	Mammalian SWI/SNF complexes promote MyoD-mediated muscle differentiation.	ARID1B SMARCD2	1.03e-03	15	111	2	11175787
Pubmed	Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2.	ACVR2B MSTN	1.03e-03	15	111	2	24019467
Pubmed	Regulation of dendritic development by neuron-specific chromatin remodeling complexes.	ARID1B SMARCD2	1.03e-03	15	111	2	17920018
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ANKRD62 ZBTB26 NLGN3 VPS13D N4BP2 TTC21B DDHD2	1.05e-03	493	111	7	15368895
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	DPYD NPEPPS COPS7A VPS13D SLC25A13 RBM46 IK	1.10e-03	497	111	7	36774506
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	NPEPPS MED1 MEN1 RLF XRN1 SCO1 PIP5K1A CPSF3	1.11e-03	645	111	8	25281560
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	APOB ACSL3 PTPN14 CLK2 SLC25A13 ATP13A3 GCN1	1.13e-03	499	111	7	22810586
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SETX NOA1 SBNO2 ASB3 XRN1 PIP5K1A SLC12A7 CLEC16A	1.17e-03	650	111	8	38777146
Pubmed	Mesenchymal Deletion of Histone Demethylase NO66 in Mice Promotes Bone Formation.	RIOX1 ALPL	1.18e-03	16	111	2	25736226
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	CAD ZCCHC8 RSBN1 IK TAF1L GCN1	1.23e-03	370	111	6	22922362
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CAD SETX NPEPPS ASAP1 RLF ACSL3 PTPN14 SLC25A13 XRN1 IK GCN1 CPSF3	1.30e-03	1353	111	12	29467282
Pubmed	TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease.	VPS13D SLC12A7 NNT	1.31e-03	67	111	3	34644545
Pubmed	Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies.	SLC25A13 GCN1 NNT	1.31e-03	67	111	3	30669930
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	CAD APOB NBPF15 SLC25A13 HACE1 TTC21B XRN1	1.32e-03	513	111	7	25798074
Pubmed	Identification of a polymorphic, neuron-specific chromatin remodeling complex.	ARID1B SMARCD2	1.33e-03	17	111	2	12368262
Pubmed	The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes.	ARID1B SMARCD2	1.33e-03	17	111	2	11078522
Pubmed	Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in β-adrenergic receptor signaling.	MED1 ARRDC3	1.33e-03	17	111	2	28291835
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	MYO1A NPEPPS RIOX1 PFDN4 CEP192 COPS7A TMEM160 SLC25A13 GCN1 LSM7	1.44e-03	1005	111	10	19615732
Pubmed	mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad.	CAD SMARCD2	1.49e-03	18	111	2	14559996
Pubmed	BAF complexes facilitate decatenation of DNA by topoisomerase IIα.	ARID1B SMARCD2	1.49e-03	18	111	2	23698369
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	CAD MEN1 STXBP3 XRN1 PIP5K1A GCN1 NNT	1.66e-03	534	111	7	35032548
Pubmed	Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction.	ARID1B SMARCD2	1.67e-03	19	111	2	16932743
Pubmed	Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes.	ARID1B SMARCD2	1.67e-03	19	111	2	12110891
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	ZCCHC8 MED1 ARID1B SMARCD2 IK	1.73e-03	268	111	5	33640491
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SETX ZCCHC8 CEP192 DNAH7 VPS13D PTPN14 N4BP2 XRN1 PPP1R12C	1.79e-03	861	111	9	36931259
Pubmed	Repression of rRNA transcription by PARIS contributes to Parkinson's disease.	CAD NPEPPS RIOX1 SLC25A13 GCN1	1.84e-03	272	111	5	25315684
Pubmed	An investigation into the human serum "interactome".	SETX RLF SLC25A13 GCN1	1.85e-03	162	111	4	15174051
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	NOA1 ASAP1 COPS7A ACSL3 TMEM160 SLC25A13 IK	1.91e-03	547	111	7	37267103
Pubmed	Interactome profiling reveals interaction of SARS-CoV-2 NSP13 with host factor STAT1 to suppress interferon signaling.	CAD ACSL3 SLC25A13 GCN1	2.02e-03	166	111	4	34687317
Pubmed	Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.	ZCCHC8 N4BP2 XRN1 GCN1	2.15e-03	169	111	4	31462741
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	NPEPPS EIPR1 ACSL3 SLC25A13 PIP5K1A IK NNT	2.17e-03	560	111	7	35241646
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	CEP192 STXBP3 CSNK1G3 SLC25A13 SMARCD2 GNA11 ATP13A3 SLC12A7	2.19e-03	719	111	8	35337019
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	TBXAS1 CEP192 DNAH7 TMEM160	2.20e-03	170	111	4	23314748
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RARG MYO1A PCDHGC4 APOB MEN1 ACSL3 N4BP2 SCG3 SLC25A13 XRN1 SMARCD2 CADPS2	2.21e-03	1442	111	12	35575683
Cytoband	5p15	TENT4A SLC12A7	1.21e-04	7	111	2	5p15
Coexpression	ZHANG_BREAST_CANCER_PROGENITORS_UP	SETX ZCCHC8 KIF16B ANKRD62 CEP192 ACSL3 PTPN14 N4BP2 HACE1 IK LSM7	3.29e-06	448	111	11	MM1044
Coexpression	GSE7218_IGM_VS_IGG_SIGNAL_THGOUGH_ANTIGEN_BCELL_UP	DOCK1 ARL2BP CAD SETX PTPN14 TTC7B NNT	1.53e-05	187	111	7	M6807
Coexpression	ZHANG_BREAST_CANCER_PROGENITORS_UP	SETX ZCCHC8 KIF16B CEP192 ACSL3 PTPN14 N4BP2 HACE1 IK LSM7	1.62e-05	434	111	10	M15150
Coexpression	GSE18281_PERIMEDULLARY_CORTICAL_REGION_VS_WHOLE_CORTEX_THYMUS_DN	MYO1A ASIC2 ITGA8 MCF2 ACVR2B TAT LARGE1	2.00e-05	195	111	7	M7263
Coexpression	CARDOSO_RESPONSE_TO_GAMMA_RADIATION_AND_3AB	GSTT2B GSTT2 BNIP2	3.98e-05	16	111	3	MM699
Coexpression	ZHAN_MULTIPLE_MYELOMA_PR_DN	DPYD RSBN1 FGD4 DDHD2	5.57e-05	49	111	4	M10412
Disease	Charcot-Marie-Tooth disease (biomarker_via_orthology)	GSTT2B GSTT2	1.30e-05	2	107	2	DOID:10595 (biomarker_via_orthology)
Disease	familial combined hyperlipidemia (is_marker_for)	APOB ALPL	1.94e-04	6	107	2	DOID:13809 (is_marker_for)
Disease	social communication impairment	DOCK1 TTC21B CLEC16A	2.13e-04	32	107	3	EFO_0005427
Disease	multiple sclerosis	RASGRF1 TENT4A NPEPPS PFDN4 TEF ASAP1 N4BP2 HACE1 CLEC16A	3.19e-04	594	107	9	MONDO_0005301
Disease	alcohol consumption measurement	DOCK1 EEF1AKMT4-ECE2 CAD GPRC6A ACVR2B MED1 RWDD3 TEF COPS7A ASB3 HACE1 XRN1 CLEC16A	5.64e-04	1242	107	13	EFO_0007878
Disease	uremia (biomarker_via_orthology)	MSTN ALPL	5.75e-04	10	107	2	DOID:4676 (biomarker_via_orthology)
Disease	Neuroblastoma	ARID1B PTPN14 HACE1	6.69e-04	47	107	3	C0027819
Disease	cognitive function measurement	DPYD RARG ASIC2 ZDBF2 CEP192 TEF ARID1B FGD4 TMEM160 SCG3 ASB3 TTC21B RBM46 LARGE1	6.81e-04	1434	107	14	EFO_0008354
Disease	Drug habituation	DOCK1 EIPR1 TTC21B CADPS2	8.30e-04	115	107	4	C0013170
Disease	Drug abuse	DOCK1 EIPR1 TTC21B CADPS2	8.30e-04	115	107	4	C0013146
Disease	Prescription Drug Abuse	DOCK1 EIPR1 TTC21B CADPS2	8.30e-04	115	107	4	C4316881
Disease	Substance-Related Disorders	DOCK1 EIPR1 TTC21B CADPS2	8.30e-04	115	107	4	C0236969
Disease	Drug Use Disorders	DOCK1 EIPR1 TTC21B CADPS2	8.30e-04	115	107	4	C0013222
Disease	Drug Dependence	DOCK1 EIPR1 TTC21B CADPS2	8.30e-04	115	107	4	C1510472
Disease	Substance Dependence	DOCK1 EIPR1 TTC21B CADPS2	8.30e-04	115	107	4	C0038580
Disease	Substance Use Disorders	DOCK1 EIPR1 TTC21B CADPS2	8.30e-04	115	107	4	C0038586
Disease	Organic Mental Disorders, Substance-Induced	DOCK1 EIPR1 TTC21B CADPS2	8.30e-04	115	107	4	C0029231
Disease	total cholesterol measurement, diastolic blood pressure, triglyceride measurement, systolic blood pressure, hematocrit, ventricular rate measurement, glucose measurement, body mass index, high density lipoprotein cholesterol measurement	TENT4A ZCCHC8 APOB	8.51e-04	51	107	3	EFO_0004340, EFO_0004348, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928
Disease	Substance abuse problem	DOCK1 EIPR1 TTC21B CADPS2	8.57e-04	116	107	4	C0740858
Disease	3-formylindole measurement	GSTT2B GSTT2	9.90e-04	13	107	2	EFO_0801025
Disease	mean platelet volume	PCDHGC4 NPEPPS KIF16B ASAP1 ACSL3 RSBN1 FGD4 GNA11 ATP13A3 SLC12A7 NNT	1.20e-03	1020	107	11	EFO_0004584
Disease	Hallux valgus	DPP10 PPP4R1L HACE1	1.37e-03	60	107	3	HP_0001822
Disease	platelet component distribution width	TENT4A NPEPPS KIF16B RWDD3 ASAP1 ACSL3 ATP13A3 ARRDC3 SLC12A7	1.73e-03	755	107	9	EFO_0007984
Disease	Stuttering	KIF16B MEN1 ASB3 LARGE1	1.85e-03	143	107	4	HP_0025268
Disease	total cholesterol measurement, hematocrit, stroke, ventricular rate measurement, body mass index, atrial fibrillation, high density lipoprotein cholesterol measurement, coronary artery disease, diastolic blood pressure, triglyceride measurement, systolic blood pressure, heart failure, diabetes mellitus, glucose measurement, mortality, cancer	TENT4A ZCCHC8 APOB	2.04e-03	69	107	3	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004340, EFO_0004348, EFO_0004352, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928, MONDO_0004992
Disease	body weight	IPPK DOCK1 DPYD RASGRF1 TENT4A CEP192 SBNO2 ACSL3 PTPN14 ASB3 HACE1 CADPS2	2.07e-03	1261	107	12	EFO_0004338
Disease	Liver diseases	AMACR SCO1 ALPL	2.31e-03	72	107	3	C0023895
Disease	Liver Dysfunction	AMACR SCO1 ALPL	2.31e-03	72	107	3	C0086565
Disease	Neutropenia	DPYD SMARCD2	2.62e-03	21	107	2	C0027947
Disease	Hodgkins lymphoma	KIF16B ESYT3 CLEC16A	3.34e-03	82	107	3	EFO_0000183

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLLGDAYMNILEPEE	TTC21B	726	Q7Z4L5
FEFMVYEVPGQDLEV	ESYT3	361	A0FGR9
YELLDELMDFGFPQT	AP1M2	111	Q9Y6Q5
YVFGELLDMPNVREL	COPS7A	41	Q9UBW8
GLEGMDALPYIDLID	CPSF3	46	Q9UKF6
NQEMELFELPATYEI	ATP13A3	606	Q9H7F0
QLFDLIESMLEYEPA	CLK2	451	P49760
MAVGAIEPQFYELLI	AMACR	231	Q9UHK6
DELPYSDDENFMLLI	ANKRD62	391	A6NC57
EYTEELVTQGLPLMF	BTBD11	856	A6QL63
LPYDVVNFEIELMKD	DPYD	236	Q12882
LIDIFGILMEYEVGD	ARID1B	1761	Q8NFD5
GYLEDIIMDDEFQLL	ARL2BP	26	Q9Y2Y0
YALLLIMDEEPGGQL	DPP10	561	Q8N608
VYVDIPGAMDLFLNL	ARRDC3	291	Q96B67
GLEIMLDIQQDEYLP	ASIC2	216	Q16515
VPLMDARINAYIEEE	KIF16B	1111	Q96L93
DMYEDELVPVFERAG	RBM46	71	Q8TBY0
VFAFAGQLLPLEMDD	RARG	311	P13631
QVQMLDLLDIEGLYP	IPPK	326	Q9H8X2
YPMALGNLADLEELE	MEN1	281	O00255
MVYDITPELAQAFLE	OTOA	296	Q7RTW8
MELDVQEYEFIVLPN	LARGE1	686	O95461
LSVDPYMEIDAFVLL	LBP	356	P18428
CVPILADEIYGDMVF	TAT	241	P17735
MGVLDIYGFEILEDN	MYO1A	376	Q9UBC5
QRADLLEVLDMYPAF	KCNH6	686	Q9H252
DDDCLMIPYQIGDVF	PFDN4	61	Q9NQP4
IYEMLGEEEDIVNPS	FGD4	406	Q96M96
FDEYELELLLSGMPE	HACE1	776	Q8IYU2
FELIDMDAGSLYEPV	DDHD2	26	O94830
LGANGLLIEYEDMFP	HEXD	36	Q8WVB3
IVLVMEYVDGGELFD	MYLK4	176	Q86YV6
PEDFEDILATIYFLM	METTL23	106	Q86XA0
EEFAIMQTPAGELYD	GCN1	761	Q92616
FAPLLYVIENEMADS	KCNG1	391	Q9UIX4
LEFVTEGPLEMYRAE	PCDHGC4	106	Q9Y5F7
EGPLEMYRAEVEIVD	PCDHGC4	111	Q9Y5F7
FEYLEEFPIQMLAQL	FOXRED2	466	Q8IWF2
EELMQPVALGYELFE	GSTT2B	171	P0CG30
YNAMVLELLGPSLED	CSNK1G3	111	Q9Y6M4
FLQDIPDGLFLDADM	PIP5K1A	286	Q99755
MEDDAPVIYGLEFQA	EIPR1	1	Q53HC9
EGAYEAELFVMIPEE	ITGA8	681	P53708
AELFVMIPEEADYVG	ITGA8	686	P53708
DENLGMLLVEFFELY	TENT4A	406	Q5XG87
MAEYDLQNDVFIIPD	GPRC6A	491	Q5T6X5
LLGLFEPGDMQYELN	ALPL	286	P05186
DPEILMEQGEFLNYD	NLGN3	386	Q9NZ94
DAIYDMIGFPDFILE	EEF1AKMT4-ECE2	611	P0DPD8
DESYNLMFEVPLDIS	GSAP	241	A4D1B5
IMALREEYFDPSIVG	APOB	4381	P04114
EDVLRMYEVPELAAI	ASB3	501	Q9Y575
IGEDAEVLMSLYDPV	DOCK1	236	Q14185
DLLEAYGIDVMLVID	DENND11	436	A4D1U4
LPEDSYMDVVFLIDN	COL6A5	1956	A8TX70
EYPFDLENIIFRMVD	GNA11	191	P29992
EELMQPVALGYELFE	GSTT2	171	P0CG29
FLDMNLEPYIDRFEG	DNAH7	876	Q8WXX0
QVYAEGVELMEPLLE	ASAP1	581	Q9ULH1
EPQELMQLEGYTVDY	CADPS2	531	Q86UW7
FNLAELAELVPMEYV	BNIP2	276	Q12982
IENFLEMALPFINYE	MCF2	366	P10911
DPLLNLVLDGTIEYM	LSM7	41	Q9UK45
FEQLAIPGMIYEDLE	CEP192	231	Q8TEP8
YQGEELSMVILLPDD	SERPINB1	221	P30740
RDIEFELLDYGPNGM	ENPP7	271	Q6UWV6
ELYPIDDVFLGMCLE	B3GNT7	321	Q8NFL0
DENYMEFLEVLTEGL	SLC12A7	1051	Q9Y666
TIIMYLIGPDGEFLD	SCO1	261	O75880
MAEIPLYFVDLQDDL	PPP4R1L	1	Q9P1A2
MGFPLIYVEAEQVED	NPEPPS	501	P55786
GDMQERFLFPEYILD	NOA1	66	Q8NC60
DMFYVEVQLDPAGQL	MED1	106	Q15648
EVLLEALFLTVDPYM	PTGR1	36	Q14914
QEYVDIMEELLGPSL	NUTM2D	446	Q5VT03
LLAEAGVPYDIVLEM	NNT	976	Q13423
EVGDYFPEFLDMLEE	RSBN1	486	Q5VWQ0
EVMRLLLQAGYDPEL	PPP1R12C	241	Q9BZL4
LYGVLMEVEEPEVLQ	NBPF15	591	Q8N660
DLILAEYSEENGPLM	TAF1L	696	Q8IZX4
GLSVVPDEEVIEMYE	NT5DC3	176	Q86UY8
GDLFDLAVPMPEVLY	OPLAH	116	O14841
YLFMLIVAGPVDLNE	MSTN	11	O14793
ILPAEAELMYINEVE	PTPN14	196	Q15678
MEFYLEIDPVTLNLI	SMIM36	1	A0A1B0GVT2
ELYIVDNNGEMPLFD	SETX	86	Q7Z333
LEYMDLDEFLLENGI	TEF	96	Q10587
MGILDLAPGIEEIYE	SBNO2	1006	Q9Y2G9
ELTFQAMAYDLLPIE	STXBP3	251	O00186
DLFDILLPMLNIYQE	RASGRF1	321	Q13972
EIYPQQADAMELLLG	RIOX1	586	Q9H6W3
ELVPESQAYMDLLAF	SMARCD2	151	Q92925
MAERIPELGEEDVYI	ACSL3	311	O95573
PVDEYMLPFEEEIGQ	ACVR2B	406	Q13705
PMEVDILFQLADLYE	SLC25A13	266	Q9UJS0
FLAVDIYQMSLVEPD	CLEC16A	726	Q2KHT3
SPDEVLENIYGLMEG	TPPP2	86	P59282
AEGFMDVDIPLELVF	RWDD3	41	Q9Y3V2
LEEGLPYLDMVIAET	TBXAS1	386	P24557
MAAEVYFGDLELFEP	ZCCHC8	1	Q6NZY4
EFLIEPSLDGFNMLE	RLF	416	Q13129
PSLDGFNMLEELYLQ	RLF	421	Q13129
IPEFDNLYLDMNGII	XRN1	26	Q8IZH2
FEIMYDSDVLQPVAG	ZDBF2	1241	Q9HCK1
LFLPGRMAYVVDLDD	IK	231	Q13123
FEVVMDIYELENPEG	CAD	996	P27708
DIYELENPEGVILSM	CAD	1001	P27708
NILREMLEYFGVPVE	MTFR2	6	Q6P444
IIDMALSEYPENFIL	TTC7B	571	Q86TV6
YMGQLELDVELVPED	TMEM160	156	Q9NX00
PEEGVSYLENLDEMI	SCG3	321	Q8WXD2
GVLEFPEMELVNYLT	ZBTB26	91	Q9HCK0
GEPIEEFMRPYDLQD	VPS13D	2256	Q5THJ4
APQEIYQDLIILMEE	LIPK	381	Q5VXJ0
EIFSDLDPDVVYLML	N4BP2	56	Q86UW6