Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor activity	LRP8 LRP1 LRP6 SORL1	2.36e-06	16	123	4	GO:0005041
GeneOntologyMolecularFunction	lipoprotein particle receptor activity	LRP8 LRP1 LRP6 SORL1	7.57e-06	21	123	4	GO:0030228
GeneOntologyMolecularFunction	serine-type endopeptidase activity	BMP1 FAP TLL1 TLL2 RHBDL3 C1S MMP9 PROC	2.35e-05	190	123	8	GO:0004252
GeneOntologyMolecularFunction	recombination hotspot binding	PRDM7 PRDM9	3.76e-05	2	123	2	GO:0010844
GeneOntologyMolecularFunction	serine-type peptidase activity	BMP1 FAP TLL1 TLL2 RHBDL3 C1S MMP9 PROC	4.33e-05	207	123	8	GO:0008236
GeneOntologyMolecularFunction	serine hydrolase activity	BMP1 FAP TLL1 TLL2 RHBDL3 C1S MMP9 PROC	5.12e-05	212	123	8	GO:0017171
GeneOntologyMolecularFunction	HLA-E specific inhibitory MHC class Ib receptor activity	KLRC1 KLRC2	2.24e-04	4	123	2	GO:0062082
GeneOntologyMolecularFunction	inhibitory MHC class Ib receptor activity	KLRC1 KLRC2	2.24e-04	4	123	2	GO:0062080
GeneOntologyMolecularFunction	histone H3K36me/H3K36me2 demethylase activity	KDM2B KDM2A	2.24e-04	4	123	2	GO:0140680
GeneOntologyMolecularFunction	apolipoprotein binding	LRP8 LRP1 LRP6	2.41e-04	20	123	3	GO:0034185
GeneOntologyMolecularFunction	endopeptidase activity	PSEN1 ADAM22 BMP1 FAP TLL1 TLL2 RHBDL3 C1S MMP9 PROC	3.33e-04	430	123	10	GO:0004175
GeneOntologyMolecularFunction	phosphatidylserine flippase activity	ATP8A2 ATP8A1	3.72e-04	5	123	2	GO:0140346
GeneOntologyMolecularFunction	2'-5'-oligoadenylate synthetase activity	OAS1 OASL	3.72e-04	5	123	2	GO:0001730
GeneOntologyMolecularFunction	ATP hydrolysis activity	DHX36 ATP8A2 SRP54 CHD8 ATP13A2 MDN1 ATP8A1 SHOC1 ASCC3 TOR3A	4.06e-04	441	123	10	GO:0016887
GeneOntologyMolecularFunction	histone modifying activity	MIER2 MIER3 PRDM7 PRDM9 KDM2B KDM2A OGA	5.48e-04	229	123	7	GO:0140993
GeneOntologyMolecularFunction	mechanosensitive monoatomic cation channel activity	PIEZO1 NALF1	7.75e-04	7	123	2	GO:0140135
GeneOntologyMolecularFunction	aminophospholipid flippase activity	ATP8A2 ATP8A1	7.75e-04	7	123	2	GO:0015247
GeneOntologyMolecularFunction	metalloendopeptidase activity	ADAM22 BMP1 TLL1 TLL2 MMP9	8.86e-04	120	123	5	GO:0004222
GeneOntologyMolecularFunction	MHC class I protein complex binding	KLRC1 KLRC2	1.03e-03	8	123	2	GO:0023024
GeneOntologyMolecularFunction	zinc ion binding	TUT4 APOBEC3D TRIM26 NR6A1 ATP13A2 APOBEC3B BMP1 ZDHHC15 PRDM9 TLL1 TLL2 KDM2B KDM2A MMP9	1.18e-03	891	123	14	GO:0008270
GeneOntologyMolecularFunction	deaminase activity	AMPD1 APOBEC3D APOBEC3B	1.19e-03	34	123	3	GO:0019239
GeneOntologyMolecularFunction	phosphatidylserine floppase activity	ATP8A2 ATP8A1	1.32e-03	9	123	2	GO:0090556
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	AMPD1 APOBEC3D APOBEC3B	1.40e-03	36	123	3	GO:0016814
GeneOntologyMolecularFunction	unmethylated CpG binding	KDM2B KDM2A	1.64e-03	10	123	2	GO:0045322
GeneOntologyMolecularFunction	cargo receptor activity	LRP8 LRP1 LRP6 SORL1	1.89e-03	85	123	4	GO:0038024
GeneOntologyMolecularFunction	histone H3K36 demethylase activity	KDM2B KDM2A	2.00e-03	11	123	2	GO:0051864
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	MIER2 AMPD1 APOBEC3D MIER3 APOBEC3B	2.11e-03	146	123	5	GO:0016810
GeneOntologyMolecularFunction	peptidase activity	PSEN1 USP9Y ADAM22 BMP1 FAP TLL1 TLL2 RHBDL3 C1S MMP9 PROC	2.39e-03	654	123	11	GO:0008233
Domain	EGF-like_dom	EREG IMPG1 ADAM22 ADGRL4 LRP8 BMP1 TLL1 TLL2 LRP1 LRP6 C1S PROC SORL1	9.31e-09	249	122	13	IPR000742
Domain	EGF_3	EREG ADAM22 ADGRL4 LRP8 BMP1 TLL1 TLL2 LRP1 LRP6 C1S PROC SORL1	4.56e-08	235	122	12	PS50026
Domain	EGF	EREG LRP8 BMP1 TLL1 TLL2 LRP1 LRP6 C1S PROC	1.39e-07	126	122	9	PF00008
Domain	EGF-like_CS	EREG ADAM22 ADGRL4 LRP8 BMP1 TLL1 TLL2 LRP1 LRP6 C1S PROC SORL1	1.43e-07	261	122	12	IPR013032
Domain	EGF_2	EREG ADAM22 ADGRL4 LRP8 BMP1 TLL1 TLL2 LRP1 LRP6 C1S PROC SORL1	1.69e-07	265	122	12	PS01186
Domain	EGF_Ca-bd_CS	ADGRL4 LRP8 BMP1 TLL1 TLL2 LRP1 C1S PROC	2.34e-07	97	122	8	IPR018097
Domain	BMP_1/tolloid-like	BMP1 TLL1 TLL2	2.72e-07	3	122	3	IPR015446
Domain	EGF_CA	ADGRL4 LRP8 BMP1 TLL1 TLL2 LRP1 C1S PROC	2.74e-07	99	122	8	PS01187
Domain	EGF	EREG ADAM22 ADGRL4 LRP8 BMP1 TLL1 TLL2 LRP1 LRP6 PROC SORL1	4.08e-07	235	122	11	SM00181
Domain	EGF-type_Asp/Asn_hydroxyl_site	ADGRL4 LRP8 BMP1 TLL1 TLL2 LRP1 C1S PROC	4.65e-07	106	122	8	IPR000152
Domain	EGF_CA	ADGRL4 LRP8 BMP1 TLL1 TLL2 LRP1 C1S PROC	1.36e-06	122	122	8	SM00179
Domain	EGF_CA	ADGRL4 LRP8 BMP1 TLL1 TLL2 LRP1 C1S	1.50e-06	86	122	7	PF07645
Domain	EGF-like_Ca-bd_dom	ADGRL4 LRP8 BMP1 TLL1 TLL2 LRP1 C1S PROC	1.54e-06	124	122	8	IPR001881
Domain	Ldl_recept_b	LRP8 LRP1 LRP6 SORL1	1.65e-06	14	122	4	PF00058
Domain	LDLRB	LRP8 LRP1 LRP6 SORL1	1.65e-06	14	122	4	PS51120
Domain	LY	LRP8 LRP1 LRP6 SORL1	2.24e-06	15	122	4	SM00135
Domain	LDLR_classB_rpt	LRP8 LRP1 LRP6 SORL1	2.24e-06	15	122	4	IPR000033
Domain	Peptidase_M12A	BMP1 TLL1 TLL2	5.36e-06	6	122	3	IPR001506
Domain	Astacin	BMP1 TLL1 TLL2	5.36e-06	6	122	3	PF01400
Domain	LDLR_class-A_CS	SPINT1 LRP8 LRP1 LRP6 SORL1	6.00e-06	40	122	5	IPR023415
Domain	EGF_1	EREG ADAM22 LRP8 BMP1 TLL1 TLL2 LRP1 LRP6 C1S PROC	6.81e-06	255	122	10	PS00022
Domain	Ldl_recept_a	SPINT1 LRP8 LRP1 LRP6 SORL1	1.09e-05	45	122	5	PF00057
Domain	-	SPINT1 LRP8 LRP1 LRP6 SORL1	1.21e-05	46	122	5	4.10.400.10
Domain	LDLRA_1	SPINT1 LRP8 LRP1 LRP6 SORL1	1.50e-05	48	122	5	PS01209
Domain	LDrepeatLR_classA_rpt	SPINT1 LRP8 LRP1 LRP6 SORL1	1.66e-05	49	122	5	IPR002172
Domain	LDLa	SPINT1 LRP8 LRP1 LRP6 SORL1	1.66e-05	49	122	5	SM00192
Domain	LDLRA_2	SPINT1 LRP8 LRP1 LRP6 SORL1	1.66e-05	49	122	5	PS50068
Domain	Peptidase_Metallo	BMP1 TLL1 TLL2 MMP9	3.63e-05	29	122	4	IPR006026
Domain	ZnMc	BMP1 TLL1 TLL2 MMP9	3.63e-05	29	122	4	SM00235
Domain	ASX_HYDROXYL	ADGRL4 LRP8 BMP1 LRP1 C1S PROC	4.96e-05	100	122	6	PS00010
Domain	-	LRP8 LRP1 LRP6 SORL1	1.19e-04	39	122	4	2.120.10.30
Domain	PHD_4	KDM2B KDM2A	1.26e-04	3	122	2	PF16866
Domain	-	ADAM22 BMP1 TLL1 TLL2 MMP9	1.89e-04	81	122	5	3.40.390.10
Domain	MetalloPept_cat_dom	ADAM22 BMP1 TLL1 TLL2 MMP9	1.89e-04	81	122	5	IPR024079
Domain	6-blade_b-propeller_TolB-like	LRP8 LRP1 LRP6 SORL1	2.29e-04	46	122	4	IPR011042
Domain	OAS1_C	OAS1 OASL	2.52e-04	4	122	2	PF10421
Domain	2-5-oligoadenylate_synth_CS	OAS1 OASL	2.52e-04	4	122	2	IPR006117
Domain	25A_SYNTH_3	OAS1 OASL	2.52e-04	4	122	2	PS50152
Domain	2-5-oligoAdlate_synth_1_dom2/C	OAS1 OASL	2.52e-04	4	122	2	IPR018952
Domain	2-5A_synthase	OAS1 OASL	2.52e-04	4	122	2	IPR026774
Domain	-	OAS1 OASL	2.52e-04	4	122	2	1.10.1410.20
Domain	25A_SYNTH_1	OAS1 OASL	2.52e-04	4	122	2	PS00832
Domain	25A_SYNTH_2	OAS1 OASL	2.52e-04	4	122	2	PS00833
Domain	CUB	BMP1 TLL1 TLL2 C1S	2.93e-04	49	122	4	PF00431
Domain	CUB	BMP1 TLL1 TLL2 C1S	3.16e-04	50	122	4	SM00042
Domain	-	BMP1 TLL1 TLL2 C1S	3.68e-04	52	122	4	2.60.120.290
Domain	CUB	BMP1 TLL1 TLL2 C1S	3.96e-04	53	122	4	PS01180
Domain	2-5-oligoadenylate_synth_N	OAS1 OASL	4.18e-04	5	122	2	IPR006116
Domain	ZINC_PROTEASE	ADAM22 BMP1 TLL1 TLL2 MMP9	4.58e-04	98	122	5	PS00142
Domain	CUB_dom	BMP1 TLL1 TLL2 C1S	5.24e-04	57	122	4	IPR000859
Domain	SSXRD	PRDM7 PRDM9	1.15e-03	8	122	2	PF09514
Domain	SSXRD_motif	PRDM7 PRDM9	1.15e-03	8	122	2	IPR019041
Domain	-	ATP8A2 ATP13A2 ATP8A1	1.17e-03	32	122	3	3.40.1110.10
Domain	-	ATP8A2 ATP13A2 ATP8A1	1.17e-03	32	122	3	2.70.150.10
Domain	Ptc/Disp	NPC1 PTCHD1	1.48e-03	9	122	2	IPR003392
Domain	Patched	NPC1 PTCHD1	1.48e-03	9	122	2	PF02460
Domain	ATPase_P-typ_cyto_domN	ATP8A2 ATP13A2 ATP8A1	1.53e-03	35	122	3	IPR023299
Domain	ATPase_P-typ_P_site	ATP8A2 ATP13A2 ATP8A1	1.66e-03	36	122	3	IPR018303
Domain	P_typ_ATPase	ATP8A2 ATP13A2 ATP8A1	1.66e-03	36	122	3	IPR001757
Domain	ATPASE_E1_E2	ATP8A2 ATP13A2 ATP8A1	1.66e-03	36	122	3	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP8A2 ATP13A2 ATP8A1	1.80e-03	37	122	3	IPR008250
Domain	E1-E2_ATPase	ATP8A2 ATP13A2 ATP8A1	1.80e-03	37	122	3	PF00122
Domain	KRAB_RELATED	PRDM7 PRDM9	2.24e-03	11	122	2	PS50806
Domain	NTP_transf_2	TUT4 OAS1	2.24e-03	11	122	2	PF01909
Domain	ZF_CXXC	KDM2B KDM2A	2.24e-03	11	122	2	PS51058
Domain	Polymerase_NTP_transf_dom	TUT4 OAS1	2.24e-03	11	122	2	IPR002934
Domain	Znf_CXXC	KDM2B KDM2A	2.24e-03	11	122	2	IPR002857
Domain	zf-CXXC	KDM2B KDM2A	2.24e-03	11	122	2	PF02008
Domain	APOBEC_N	APOBEC3D APOBEC3B	2.68e-03	12	122	2	PF08210
Domain	APOBEC_N	APOBEC3D APOBEC3B	2.68e-03	12	122	2	IPR013158
Domain	Rossmann-like_a/b/a_fold	WARS1 LARS2 CRY2	2.77e-03	43	122	3	IPR014729
Domain	-	WARS1 LARS2 CRY2	2.77e-03	43	122	3	3.40.50.620
Domain	SSD	NPC1 PTCHD1	3.15e-03	13	122	2	IPR000731
Domain	ELM2_dom	MIER2 MIER3	3.15e-03	13	122	2	IPR000949
Domain	SSD	NPC1 PTCHD1	3.15e-03	13	122	2	PS50156
Domain	Krueppel-associated_box-rel	PRDM7 PRDM9	3.15e-03	13	122	2	IPR003655
Domain	ELM2	MIER2 MIER3	3.15e-03	13	122	2	PF01448
Domain	ELM2	MIER2 MIER3	3.15e-03	13	122	2	PS51156
Domain	ELM2	MIER2 MIER3	3.15e-03	13	122	2	SM01189
Domain	P_typ_ATPase_c	ATP8A2 ATP8A1	3.66e-03	14	122	2	IPR032630
Domain	P-type_ATPase_N	ATP8A2 ATP8A1	3.66e-03	14	122	2	IPR032631
Domain	P-type_ATPase_IV	ATP8A2 ATP8A1	3.66e-03	14	122	2	IPR006539
Domain	APOBEC/CMP_deaminase_Zn-bd	APOBEC3D APOBEC3B	3.66e-03	14	122	2	IPR016192
Domain	PhoLip_ATPase_C	ATP8A2 ATP8A1	3.66e-03	14	122	2	PF16212
Domain	PhoLip_ATPase_N	ATP8A2 ATP8A1	3.66e-03	14	122	2	PF16209
Domain	-	PTPN21 PTPN3 ACBD3	4.02e-03	49	122	3	1.20.80.10
Domain	TBC	SGSM1 TBC1D2 TBCK	4.02e-03	49	122	3	SM00164
Domain	FERM/acyl-CoA-bd_prot_3-hlx	PTPN21 PTPN3 ACBD3	4.26e-03	50	122	3	IPR014352
Domain	FBOX	FBXW4 KDM2B KDM2A	4.76e-03	52	122	3	SM00256
Domain	RabGAP-TBC	SGSM1 TBC1D2 TBCK	5.02e-03	53	122	3	PF00566
Domain	CYT_DCMP_DEAMINASES_1	APOBEC3D APOBEC3B	5.40e-03	17	122	2	PS00903
Domain	CMP_dCMP_Zn-bd	APOBEC3D APOBEC3B	5.40e-03	17	122	2	IPR002125
Domain	Cytidine_deaminase-like	APOBEC3D APOBEC3B	5.40e-03	17	122	2	IPR016193
Domain	Rab-GTPase-TBC_dom	SGSM1 TBC1D2 TBCK	5.57e-03	55	122	3	IPR000195
Domain	TBC_RABGAP	SGSM1 TBC1D2 TBCK	5.57e-03	55	122	3	PS50086
Domain	aa-tRNA-synth_I_CS	WARS1 LARS2	6.05e-03	18	122	2	IPR001412
Pubmed	Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.	PSEN1 LRP8 LRP1 SORL1	2.04e-08	9	126	4	20005821
Pubmed	Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.	BMP1 TLL1 TLL2	4.64e-08	3	126	3	18824173
Pubmed	Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits.	KLRC1 KLRC2 KLRC3	1.85e-07	4	126	3	8943374
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	NPC1 DHX36 WARS1 DIPK1A PIEZO1 EI24 ADAM22 LRP8 BMP1 FAP NF1 TLL1 DPY19L4 LRP1 LRP6 TOR3A SUCO SORL1	3.55e-07	1201	126	18	35696571
Pubmed	Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.	BMP1 TLL1 TLL2	4.62e-07	5	126	3	10479448
Pubmed	Development and function of CD94-deficient natural killer cells.	KLRC1 KLRC2 KLRC3	4.62e-07	5	126	3	21151939
Pubmed	Structural basis for NKG2A/CD94 recognition of HLA-E.	KLRC1 KLRC2 KLRC3	9.21e-07	6	126	3	18448674
Pubmed	Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes.	KLRC1 KLRC2 KLRC3	1.61e-06	7	126	3	9598306
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MIER2 DOCK3 PLEKHA6 ZFC3H1 BTBD9 ARMCX2 RALGAPA2 CRY2 WDR35 KDM2A LNPK	1.95e-06	493	126	11	15368895
Pubmed	Viral infection modulates Qa-1b in infected and bystander cells to properly direct NK cell killing.	KLRC1 KLRC2 KLRC3	2.57e-06	8	126	3	33765134
Pubmed	Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells.	KLRC1 KLRC2 KLRC3	2.57e-06	8	126	3	10601355
Pubmed	Bone marrow allograft rejection mediated by a novel murine NK receptor, NKG2I.	KLRC1 KLRC2 KLRC3	3.84e-06	9	126	3	14707119
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	EREG EI24 PLEKHA6 COQ3 RALGAPA2 SEC22A LCLAT1 LRP8 PTPN3 SEC23IP OASL TSPAN14	1.27e-05	719	126	12	35337019
Pubmed	Loss of apolipoprotein E receptor LR11 in Alzheimer disease.	LRP8 SORL1	1.30e-05	2	126	2	15313836
Pubmed	Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase.	LRP8 LRP1	1.30e-05	2	126	2	12871934
Pubmed	Combined expression levels of KDM2A and KDM2B correlate with nucleolar size and prognosis in primary breast carcinomas.	KDM2B KDM2A	1.30e-05	2	126	2	32901907
Pubmed	The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain.	OAS1 OASL	1.30e-05	2	126	2	18931074
Pubmed	Women with pre-eclampsia have an altered NKG2A and NKG2C receptor expression on peripheral blood natural killer cells.	KLRC1 KLRC2	1.30e-05	2	126	2	19694640
Pubmed	YKL-40 and matrix metalloproteinase-9 as potential serum biomarkers for patients with high-grade gliomas.	CHI3L1 MMP9	1.30e-05	2	126	2	17020973
Pubmed	Interleukin-1 participates in the progression from liver injury to fibrosis.	MMP9 IL1R1	1.30e-05	2	126	2	19342509
Pubmed	Skeletal muscle expression of bone morphogenetic protein-1 and tolloid-like-1 extracellular proteases in different fiber types and in response to unloading, food deprivation and differentiation.	BMP1 TLL1	1.30e-05	2	126	2	20658214
Pubmed	Differential expression of Low density lipoprotein Receptor-related Protein 1 (LRP-1) and matrix metalloproteinase-9 (MMP-9) in prostate gland: From normal to malignant lesions.	LRP1 MMP9	1.30e-05	2	126	2	27931798
Pubmed	Presenilin 1 mutations influence processing and trafficking of the ApoE receptor apoER2.	PSEN1 LRP8	1.30e-05	2	126	2	27810638
Pubmed	Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues.	BMP1 TLL1	1.30e-05	2	126	2	7798260
Pubmed	NKG2C and NKG2A coexpression defines a highly functional antiviral NK population in spontaneous HIV control.	KLRC1 KLRC2	1.30e-05	2	126	2	39288262
Pubmed	Role for NKG2-A and NKG2-C surface receptors in chronic CD4+ T-cell responses.	KLRC1 KLRC2	1.30e-05	2	126	2	15550116
Pubmed	Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator.	LRP1 MMP9	1.30e-05	2	126	2	12960961
Pubmed	Characterization of a novel gene product (mammalian tolloid-like) with high sequence similarity to mammalian tolloid/bone morphogenetic protein-1.	BMP1 TLL1	1.30e-05	2	126	2	8661043
Pubmed	Low density lipoprotein receptor related protein 1 and 6 gene variants and ischaemic stroke risk.	LRP1 LRP6	1.30e-05	2	126	2	26031789
Pubmed	Characterization of large-scale genomic differences in the first complete human genome.	KLRC2 KLRC3	1.30e-05	2	126	2	37403156
Pubmed	Chitinase 3-like-1, Tolloid-like protein 1, and intergenic gene polymorphisms are predictors for hepatocellular carcinoma development after hepatitis C virus eradication by direct-acting antivirals.	CHI3L1 TLL1	1.30e-05	2	126	2	33347699
Pubmed	Characterization of the molecular architecture of human caveolin-3 and interaction with the skeletal muscle ryanodine receptor.	CAV3 RYR1	1.30e-05	2	126	2	23071107
Pubmed	Biological Functions of the KDM2 Family of Histone Demethylases.	KDM2B KDM2A	1.30e-05	2	126	2	37751135
Pubmed	Reciprocal regulation between lunapark and atlastin facilitates ER three-way junction formation.	ATL1 LNPK	1.30e-05	2	126	2	30498943
Pubmed	Inactivation of bone morphogenetic protein 1 (Bmp1) and tolloid-like 1 (Tll1) in cells expressing type I collagen leads to dental and periodontal defects in mice.	BMP1 TLL1	1.30e-05	2	126	2	28000152
Pubmed	Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways.	ADCY10 MMP9	1.30e-05	2	126	2	17942699
Pubmed	Apolipoprotein E Receptor 2 Mediates Activated Protein C-Induced Endothelial Akt Activation and Endothelial Barrier Stabilization.	LRP8 PROC	1.30e-05	2	126	2	26800564
Pubmed	DNA Methylation of KLRC1 and KLRC3 in Autoimmune Thyroiditis: Perspective of Different Water Iodine Exposure.	KLRC1 KLRC3	1.30e-05	2	126	2	39401997
Pubmed	Differential regulation of the OASL and OAS1 genes in response to viral infections.	OAS1 OASL	1.30e-05	2	126	2	19203244
Pubmed	Proteinase bone morphogenetic protein 1, but not tolloid-like 1, plays a dominant role in maintaining periodontal homeostasis.	BMP1 TLL1	1.30e-05	2	126	2	33169406
Pubmed	KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity.	KDM2B KDM2A	1.30e-05	2	126	2	31363749
Pubmed	YKL-40 and MMP-9 as serum markers for patients with primary central nervous system lymphoma.	CHI3L1 MMP9	1.30e-05	2	126	2	21391238
Pubmed	Inverse relationship between raft LRP1 localization and non-raft ERK1,2/MMP9 activation in idiopathic dilated cardiomyopathy: potential impact in ventricular remodeling.	LRP1 MMP9	1.30e-05	2	126	2	25131918
Pubmed	Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures.	TLL1 TLL2	1.30e-05	2	126	2	11313359
Pubmed	SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.	CRY2 KDM2B KDM2A	1.64e-05	14	126	3	17463251
Pubmed	Stage-specific association of apolipoprotein A-I and E in developing mouse retina.	LRP8 LRP1 LRP6	1.64e-05	14	126	3	17389516
Pubmed	APOBEC3 deletion increases the risk of breast cancer: a meta-analysis.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	27602762
Pubmed	NKG2A/CD94 Is a New Immune Receptor for HLA-G and Distinguishes Amino Acid Differences in the HLA-G Heavy Chain.	KLRC1 KLRC2	3.90e-05	3	126	2	32575403
Pubmed	A novel role for APOBEC3: susceptibility to sexual transmission of murine acquired immunodeficiency virus (mAIDS) is aggravated in APOBEC3 deficient mice.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	22691411
Pubmed	Studies on the restriction of murine leukemia viruses by mouse APOBEC3.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	22666481
Pubmed	APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	16648136
Pubmed	Fv1 restriction and retrovirus vaccine immunity in Apobec3-deficient 129P2 mice.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	23533681
Pubmed	IFN-α treatment inhibits acute Friend retrovirus replication primarily through the antiviral effector molecule Apobec3.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	23315078
Pubmed	Requirement for Fc effector mechanisms in the APOBEC3/Rfv3-dependent neutralizing antibody response.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	25589647
Pubmed	Significance of HLA-E and its two NKG2 receptors in development of complications after allogeneic transplantation of hematopoietic stem cells.	KLRC1 KLRC2	3.90e-05	3	126	2	37901227
Pubmed	Cloning of murine NKG2A, B and C: second family of C-type lectin receptors on murine NK cells.	KLRC1 KLRC2	3.90e-05	3	126	2	10092077
Pubmed	Tissue-protective effects of NKG2A in immune-mediated clearance of virus infection.	KLRC1 KLRC2	3.90e-05	3	126	2	25251060
Pubmed	Molecular cloning of KLRI1 and KLRI2, a novel pair of lectin-like natural killer-cell receptors with opposing signalling motifs.	KLRC1 KLRC2	3.90e-05	3	126	2	15650876
Pubmed	Clearance of matrix metalloproteinase-9 is dependent on low-density lipoprotein receptor-related protein-1 expression downregulated by microRNA-205 in human abdominal aortic aneurysm.	LRP1 MMP9	3.90e-05	3	126	2	26781079
Pubmed	Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population.	KLRC1 KLRC2	3.90e-05	3	126	2	12618865
Pubmed	Use of Bmp1/Tll1 doubly homozygous null mice and proteomics to identify and validate in vivo substrates of bone morphogenetic protein 1/tolloid-like metalloproteinases.	BMP1 TLL1	3.90e-05	3	126	2	12808086
Pubmed	Requirement for CD4(+) T cells in the Friend murine retrovirus neutralizing antibody response: evidence for functional T cells in genetic low-recovery mice.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	9765497
Pubmed	BMP1 and TLL1 Are Required for Maintaining Periodontal Homeostasis.	BMP1 TLL1	3.90e-05	3	126	2	28068493
Pubmed	Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family.	OAS1 OASL	3.90e-05	3	126	2	12799444
Pubmed	YKL-40 promotes proliferation and invasion of HTR-8/SVneo cells by activating akt/MMP9 signalling in placenta accreta spectrum disorders.	CHI3L1 MMP9	3.90e-05	3	126	2	37192383
Pubmed	A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases.	KDM2B KDM2A	3.90e-05	3	126	2	30033217
Pubmed	APOBEC3 inhibition of mouse mammary tumor virus infection: the role of cytidine deamination versus inhibition of reverse transcription.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	23449789
Pubmed	The low density lipoprotein receptor-related protein modulates levels of matrix metalloproteinase 9 (MMP-9) by mediating its cellular catabolism.	LRP1 MMP9	3.90e-05	3	126	2	11279011
Pubmed	Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2.	LRP8 PROC	3.90e-05	3	126	2	18489431
Pubmed	Demethylation of epiregulin gene by histone demethylase FBXL11 and BCL6 corepressor inhibits osteo/dentinogenic differentiation.	EREG KDM2A	3.90e-05	3	126	2	23074094
Pubmed	Molecular cloning of mouse NKG2A and C.	KLRC1 KLRC2	3.90e-05	3	126	2	10369936
Pubmed	Precise Spatiotemporal Control of Nodal Na+ Channel Clustering by Bone Morphogenetic Protein-1/Tolloid-like Proteinases.	BMP1 TLL1	3.90e-05	3	126	2	32209430
Pubmed	Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells.	KLRC1 KLRC2	3.90e-05	3	126	2	10320637
Pubmed	HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses.	KLRC1 KLRC2	3.90e-05	3	126	2	37264229
Pubmed	Anti-Friend virus antibody is associated with recovery from viremia and loss of viral leukemia cell-surface antigens in leukemic mice. Identification of Rfv-3 as a gene locus influencing antibody production.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	286744
Pubmed	Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance.	NPC1 LRP6	3.90e-05	3	126	2	18948618
Pubmed	Microglial low-density lipoprotein receptor-related protein 1 mediates the effect of tissue-type plasminogen activator on matrix metalloproteinase-9 activity in the ischemic brain.	LRP1 MMP9	3.90e-05	3	126	2	19672275
Pubmed	Host restriction of murine gammaherpesvirus 68 replication by human APOBEC3 cytidine deaminases but not murine APOBEC3.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	24725948
Pubmed	Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection.	OAS1 OASL	3.90e-05	3	126	2	16235172
Pubmed	Bone morphogenetic protein-1 processes probiglycan.	BMP1 TLL1	3.90e-05	3	126	2	10896944
Pubmed	Confirmation of mutation landscape of NF1-associated malignant peripheral nerve sheath tumors.	NF1 KDM2B	3.90e-05	3	126	2	28124441
Pubmed	Genetic analysis of the role of proteolysis in the activation of latent myostatin.	BMP1 TLL2	3.90e-05	3	126	2	18286185
Pubmed	Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	284359
Pubmed	Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor.	KLRC1 KLRC2	3.90e-05	3	126	2	23340823
Pubmed	Impact of Suboptimal APOBEC3G Neutralization on the Emergence of HIV Drug Resistance in Humanized Mice.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	31801862
Pubmed	Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	31943071
Pubmed	Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	20566830
Pubmed	Chromosome mapping of Rfv3, a host resistance gene to Friend murine retrovirus.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	7884913
Pubmed	N-linked glycosylation protects gammaretroviruses against deamination by APOBEC3 proteins.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	25505062
Pubmed	Molecular analysis of γ1, γ3, and α class switch recombination junctions in APOBEC3-deficient mice using high-throughput sequencing.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	31595054
Pubmed	Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.	LRP1 SORL1	3.90e-05	3	126	2	28799085
Pubmed	Role of APOBEC3 in genetic diversity among endogenous murine leukemia viruses.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	17967065
Pubmed	Induced ablation of Bmp1 and Tll1 produces osteogenesis imperfecta in mice.	BMP1 TLL1	3.90e-05	3	126	2	24419319
Pubmed	Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	20335265
Pubmed	Relationship among LRP1 expression, Pyk2 phosphorylation and MMP-9 activation in left ventricular remodelling after myocardial infarction.	LRP1 MMP9	3.90e-05	3	126	2	28378397
Pubmed	Deaminase-Dead Mouse APOBEC3 Is an In Vivo Retroviral Restriction Factor.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	29593034
Pubmed	Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9.	LRP1 MMP9	3.90e-05	3	126	2	19176371
Pubmed	Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response.	APOBEC3D APOBEC3B	3.90e-05	3	126	2	21998583
Pubmed	Identification of neutrophil activation markers as novel surrogate markers of CF lung disease.	CHI3L1 MMP9	3.90e-05	3	126	2	25545245
Pubmed	Presenilin Deficiency Results in Cellular Cholesterol Accumulation by Impairment of Protein Glycosylation and NPC1 Function.	NPC1 PSEN1	3.90e-05	3	126	2	38791456
Cytoband	12p13	C1S KLRC1 KLRC2 KLRC3	3.03e-05	64	126	4	12p13
GeneFamily	Bone morphogenetic proteins\|Astacins	BMP1 TLL1 TLL2	1.99e-06	6	85	3	894
GeneFamily	CD molecules\|C-type lectin domain family\|Killer cell lectin like receptors	KLRC1 KLRC2 KLRC3	2.14e-05	12	85	3	621
GeneFamily	Low density lipoprotein receptors	LRP8 LRP1 LRP6	2.77e-05	13	85	3	634
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	KLRC1 KLRC2 KLRC3	9.40e-04	41	85	3	1298
GeneFamily	Zinc fingers CXXC-type	KDM2B KDM2A	1.40e-03	12	85	2	136
GeneFamily	Apolipoprotein B mRNA editing enzyme catalytic subunits	APOBEC3D APOBEC3B	1.40e-03	12	85	2	406
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	USP9Y APOBEC3B TOR3A	1.77e-03	51	85	3	870
GeneFamily	ATPase phospholipid transporting	ATP8A2 ATP8A1	2.20e-03	15	85	2	1210
GeneFamily	Zinc fingers C2H2-type\|PR/SET domain family	PRDM7 PRDM9	2.84e-03	17	85	2	1197
GeneFamily	Protein tyrosine phosphatases, non-receptor type	PTPN21 PTPN3	3.18e-03	18	85	2	812
GeneFamily	Aminoacyl tRNA synthetases, Class I	WARS1 LARS2	3.55e-03	19	85	2	131
GeneFamily	F-box and leucine rich repeat proteins	KDM2B KDM2A	4.33e-03	21	85	2	558
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM2B KDM2A	5.64e-03	24	85	2	485
Coexpression	GSE40666_STAT1_KO_VS_STAT4_KO_CD8_TCELL_WITH_IFNA_STIM_90MIN_UP	CYTH1 RALGAPA2 RNF123 DPY19L4 WDR35 LNPK SKAP2 BBS12	4.28e-06	195	124	8	M9218
Coexpression	GSE22140_GERMFREE_VS_SPF_MOUSE_CD4_TCELL_UP	NPC1 WARS1 TRIM26 OAS1 HHLA1 LIMK2 OASL C1S	4.97e-06	199	124	8	M7652
Coexpression	GSE7568_IL4_VS_IL4_AND_DEXAMETHASONE_TREATED_MACROPHAGE_DN	LAPTM4A SLCO3A1 BTBD9 ELOVL7 ATP8A1 KLRC1 SORL1	7.85e-06	151	124	7	M369
Coexpression	CROMER_TUMORIGENESIS_UP	APOBEC3B BMP1 FAP OASL MMP9	8.19e-06	58	124	5	M178
Coexpression	SOBOLEV_PBMC_PANDEMRIX_AGE_18_64YO_7DY_DN	WARS1 OAS1 APOBEC3B OASL	1.76e-05	33	124	4	M41194
Coexpression	GSE37301_HEMATOPOIETIC_STEM_CELL_VS_CD4_TCELL_UP	RALGAPA2 NF1 MMP9 SKAP2 KLRC1 KLRC2 KLRC3	2.12e-05	176	124	7	M8881
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP	TUT4 TRIM26 RALGAPA2 NF1 ATP8A1 TBCK KDM2A	2.45e-05	180	124	7	M8239
Coexpression	GSE3982_EOSINOPHIL_VS_BCELL_UP	LAPTM4A GRIA2 LIMK2 DENND1B TLL1 LRP6 C1S	4.65e-05	199	124	7	M5406
Coexpression	GSE1432_CTRL_VS_IFNG_6H_MICROGLIA_DN	WARS1 TRIM26 SRP54 LIMK2 C1S ASCC3 PDCD1LG2	4.80e-05	200	124	7	M3405
Coexpression	GSE1432_1H_VS_6H_IFNG_MICROGLIA_DN	WARS1 SRP54 LIMK2 DENND1B C1S ASCC3 PDCD1LG2	4.80e-05	200	124	7	M3411
Coexpression	GSE19772_HCMV_INFL_VS_HCMV_INF_MONOCYTES_AND_PI3K_INHIBITION_DN	LAPTM4A U2SURP EI24 COQ3 LCLAT1 IL1R1 SKAP2	4.80e-05	200	124	7	M7286
Coexpression	GSE16450_IMMATURE_VS_MATURE_NEURON_CELL_LINE_12H_IFNA_STIM_UP	AMPD1 TUT4 CYTH1 CCNG2 ZDHHC15 HSDL1 SORL1	4.80e-05	200	124	7	M7430
Coexpression	GSE37534_UNTREATED_VS_PIOGLITAZONE_TREATED_CD4_TCELL_PPARG1_AND_FOXP3_TRASDUCED_DN	WARS1 TRIM26 OAS1 LARS2 OASL C1S PDCD1LG2	4.80e-05	200	124	7	M8982
Coexpression	GSE16385_ROSIGLITAZONE_IFNG_TNF_VS_IL4_STIM_MACROPHAGE_DN	EREG THNSL1 SLCO3A1 SRP54 SCN2A RASGEF1C OGA	4.80e-05	200	124	7	M7993
Coexpression	GSE5589_LPS_AND_IL10_VS_LPS_AND_IL6_STIM_IL6_KO_MACROPHAGE_45MIN_UP	LAPTM4A PSEN1 TRIM26 SLCO3A1 OAS1 DENND1B TOR3A	4.80e-05	200	124	7	M6625
Coexpression	GSE34006_WT_VS_A2AR_KO_TREG_DN	LAPTM4A TRIM26 OAS1 APOBEC3B FAP OASL TOR3A	4.80e-05	200	124	7	M9042
Coexpression	ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF	EREG DIPK1A CYTH1 TBC1D2 SLC19A2 ACOX3 ATL1 ELOVL7 WDR35 IL1R1 PDCD1LG2	6.28e-05	550	124	11	M2611
Coexpression	WANG_SMARCE1_TARGETS_UP	WARS1 CHI3L1 FAP TLL2 C1S LNPK IL1R1 KLRC1	8.15e-05	294	124	8	M1804
Coexpression	HECKER_IFNB1_TARGETS	OAS1 CHI3L1 APOBEC3B OASL MMP9	9.01e-05	95	124	5	M3010
Coexpression	ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP	PSEN1 CYTH1 SLCO3A1 ELOVL7 CCNG2 OASL KDM2A	9.52e-05	223	124	7	M19826
Coexpression	HALLMARK_INTERFERON_ALPHA_RESPONSE	WARS1 TRIM26 OAS1 OASL C1S	9.95e-05	97	124	5	M5911
Coexpression	GSE37301_MULTIPOTENT_PROGENITOR_VS_LYMPHOID_PRIMED_MPP_UP	ADCY10 AMPD1 ZFC3H1 BPHL OASL HSDL1	1.08e-04	158	124	6	M8888
Coexpression	GSE7568_IL4_VS_IL4_AND_TGFB_TREATED_MACROPHAGE_24H_UP	CYTH1 SLCO3A1 CHD8 ZFC3H1 LIMK2 SORL1	1.47e-04	167	124	6	M365
Coexpression	GSE37605_C57BL6_VS_NOD_FOXP3_FUSION_GFP_TCONV_UP	EI24 LCLAT1 NF1 BPHL TOR3A PDCD1LG2	1.52e-04	168	124	6	M8823
Coexpression	BLUM_RESPONSE_TO_SALIRASIB_UP	NPC1 LAPTM4A WARS1 PSEN1 LRP1 SUCO ACBD3	1.70e-04	245	124	7	M7300
Coexpression	RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP	NPC1 DIPK1A CYTH1 CHI3L1 CCNG2 C1S MMP9 IL1R1	2.25e-04	341	124	8	M12636
Coexpression	GARCIA_PINERES_PBMC_HPV_16_L1_VLP_AGE_18_25YO_STIMULATED_VS_UNSTIMULATED_0DY_VACCINATION_INDEPENDENT_UP	WARS1 OAS1 APOBEC3B LIMK2 OASL C1S MMP9	2.28e-04	257	124	7	M41025
Coexpression	URS_ADIPOCYTE_DIFFERENTIATION_UP	ATP8A2 PTPN21 ACOX3 LRP8	2.74e-04	66	124	4	M15476
Coexpression	GSE21927_SPLEEN_MONOCYTE_VS_GMCSF_GCSF_BONE_MARROW_UP	SPTSSB SLC19A2 BTBD9 PRDM7 SHOC1 BBS12	2.87e-04	189	124	6	M7564
Coexpression	BROWNE_INTERFERON_RESPONSIVE_GENES	WARS1 CYTH1 OAS1 OASL	2.90e-04	67	124	4	M9221
Coexpression	ELVIDGE_HIF1A_TARGETS_UP	SLCO3A1 LARS2 SEC23IP TOR3A	2.90e-04	67	124	4	M17905
Coexpression	GSE22886_NAIVE_CD8_TCELL_VS_MEMORY_TCELL_UP	DOCK3 EI24 ATP8A1 DCLRE1C TLL2 KLRC3	3.39e-04	195	124	6	M4405
Coexpression	BENNETT_SYSTEMIC_LUPUS_ERYTHEMATOSUS	OAS1 APOBEC3B OASL	3.45e-04	29	124	3	M12175
Coexpression	GSE42021_TREG_PLN_VS_CD24LO_TREG_THYMUS_DN	OAS1 APOBEC3B TLL1 OASL FZD10 C1S	3.58e-04	197	124	6	M9580
Coexpression	GSE29949_CD8_NEG_DC_SPLEEN_VS_MONOCYTE_BONE_MARROW_UP	SPINT1 PIEZO1 CCNG2 SEC23IP KDM2A SKAP2	3.67e-04	198	124	6	M8404
Coexpression	GSE15930_NAIVE_VS_48H_IN_VITRO_STIM_IFNAB_CD8_TCELL_UP	FBXW4 SLCO3A1 ARMCX2 RNF123 CNGA2 SORL1	3.67e-04	198	124	6	M3601
Coexpression	GSE33162_UNTREATED_VS_4H_LPS_STIM_HDAC3_HET_MACROPHAGE_UP	ATP8A2 CRY2 FAP MDN1 BPHL TSPAN14	3.67e-04	198	124	6	M9035
Coexpression	PARENT_MTOR_SIGNALING_UP	OAS1 ACOX3 CCNG2 RNF123 OASL PCIF1 LRP1 IL1R1 OGA SKAP2	3.73e-04	567	124	10	M16909
Coexpression	GSE41867_MEMORY_VS_EXHAUSTED_CD8_TCELL_DAY30_LCMV_UP	TRIM26 ATP8A2 ATP8A1 TSPAN14 TOR3A SUCO	3.77e-04	199	124	6	M9480
Coexpression	GSE27786_LIN_NEG_VS_NEUTROPHIL_UP	MIER2 TUT4 DIPK1A PLEKHA6 DPY19L4 KLRC1	3.77e-04	199	124	6	M4794
Coexpression	GSE17721_LPS_VS_PAM3CSK4_0.5H_BMDC_DN	DHX36 LAPTM4A SLC19A2 PLEKHA6 LCLAT1 RHBDL3	3.77e-04	199	124	6	M3907
Coexpression	GSE30083_SP2_VS_SP3_THYMOCYTE_UP	USP9Y FAP TOR3A MMP9 BBS12 PDCD1LG2	3.77e-04	199	124	6	M5031
Coexpression	GSE14308_TH2_VS_TH1_DN	TUT4 SLCO3A1 OAS1 ACOX3 RHBDL3 TOR3A	3.88e-04	200	124	6	M3360
Coexpression	GSE28737_WT_VS_BCL6_HET_MARGINAL_ZONE_BCELL_DN	APOBEC3B SNX25 SCN2A ACBD3 KLRC3 PDCD1LG2	3.88e-04	200	124	6	M9344
Coexpression	GSE13306_TREG_VS_TCONV_LAMINA_PROPRIA_UP	NPC1 SLC19A2 SEC22A ZDHHC15 KLRC2 PDCD1LG2	3.88e-04	200	124	6	M3220
Coexpression	GSE42021_TREG_PLN_VS_TREG_PRECURSORS_THYMUS_DN	TRIM26 CYTH1 OAS1 LARS2 OASL C1S	3.88e-04	200	124	6	M9570
Coexpression	GSE42021_TREG_PLN_VS_CD24INT_TREG_THYMUS_DN	NPC1 WARS1 OAS1 OASL FZD10 C1S	3.88e-04	200	124	6	M9576
Coexpression	GSE27859_CD11C_INT_F480_HI_MACROPHAGE_VS_CD11C_ING_F480_INT_DC_DN	CHD8 CAV3 CCNG2 LRP1 OGA SORL1	3.88e-04	200	124	6	M8598
Coexpression	GSE18281_PERIMEDULLARY_CORTICAL_REGION_VS_WHOLE_CORTEX_THYMUS_UP	ADCY10 PSEN1 SLCO3A1 CHD8 LIMK2 TSPAN14	3.88e-04	200	124	6	M7256
Coexpression	GSE16697_CD4_TCELL_VS_TFH_CD4_TCELL_UP	TUT4 ATP13A2 APOBEC3B ACOX3 KDM2B KDM2A	3.88e-04	200	124	6	M7153
Coexpression	GSE23308_WT_VS_MINERALCORTICOID_REC_KO_MACROPHAGE_UP	FBXW4 ATP13A2 RNF123 BPHL KDM2B IL1R1	3.88e-04	200	124	6	M7742
Coexpression	GSE2585_AIRE_KO_VS_WT_CD80_HIGH_MTEC_UP	TBC1D2 PTPN21 BTBD9 ATP8A1 WDR35 LRP1	3.88e-04	200	124	6	M6266
Coexpression	GSE5542_UNTREATED_VS_IFNG_TREATED_EPITHELIAL_CELLS_6H_DN	NPC1 APOBEC3D PIEZO1 NF1 DENND1B ACBD3	3.88e-04	200	124	6	M6513
Coexpression	GSE38681_WT_VS_LYL1_KO_LYMPHOID_PRIMED_MULTIPOTENT_PROGENITOR_DN	TRIM26 OAS1 APOBEC3B ADAM22 OASL TOR3A	3.88e-04	200	124	6	M9020
Coexpression	GSE34006_A2AR_KO_VS_A2AR_AGONIST_TREATED_TREG_UP	LAPTM4A TRIM26 OAS1 APOBEC3B OASL TOR3A	3.88e-04	200	124	6	M9051
Coexpression	GSE9316_IL6_KO_VS_IFNG_KO_INVIVO_EXPANDED_CD4_TCELL_DN	WARS1 SLCO3A1 OAS1 OASL TOR3A PDCD1LG2	3.88e-04	200	124	6	M6892
Coexpression	GSE3982_MAC_VS_BCELL_UP	DOCK3 LAPTM4A PSEN1 BMP1 DENND1B SKAP2	3.88e-04	200	124	6	M5494
Coexpression	GSE40068_CXCR5POS_BCL6POS_TFH_VS_CXCR5NEG_BCL6NEG_CD4_TCELL_UP	AMPD1 DIPK1A ELOVL7 PCIF1 SUCO HSDL1	3.88e-04	200	124	6	M9258
Coexpression	FURUKAWA_DUSP6_TARGETS_PCI35_UP	BPHL C1S KLRC2 KLRC3	4.04e-04	73	124	4	M6998
Coexpression	TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_DN	TUT4 CHI3L1 RALGAPA2 ATP8A1 MMP9	4.19e-04	132	124	5	M15410
Coexpression	HE_LIM_SUN_FETAL_LUNG_C7_SST_POS_NEURON_CELL	DIPK1A ATP8A2 SLCO3A1 GRIA2 ATP13A2 ADAM22 SCN2A SORL1	4.24e-04	375	124	8	M45799
Coexpression	DER_IFN_ALPHA_RESPONSE_UP	TRIM26 OAS1 OASL C1S	4.25e-04	74	124	4	M3652
Coexpression	GSE6259_33D1_POS_DC_VS_CD8_TCELL_DN	SLC19A2 LCLAT1 DCLRE1C LRP6 HSDL1	4.64e-04	135	124	5	M6759
Coexpression	GSE7459_UNTREATED_VS_IL6_TREATED_ACT_CD4_TCELL_UP	AMPD1 NR6A1 RNF123 NF1 TOR3A	5.13e-04	138	124	5	M462
Coexpression	HALLMARK_COAGULATION	BMP1 LRP1 C1S MMP9 PROC	5.13e-04	138	124	5	M5946
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY10 DOCK3 USP9Y LARS2 CES4A OPN5	3.62e-06	145	126	6	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	PND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GRIA2 RASGEF1C KLRC1 KLRC2 KLRC3 PDCD1LG2	4.07e-06	148	126	6	7cb4865a1e9522e24f9c14799568b67172bd99dc
ToppCell	CV-Mild-4\|Mild / Virus stimulation, Condition and Cluster	SPINT1 NR6A1 USP9Y RYR1 CCNG2 LNPK	6.38e-06	160	126	6	2e24f8de5086b086863d3bf4d9afbd9bc93f4d5e
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADCY10 DOCK3 USP9Y LARS2 CES4A OPN5	6.85e-06	162	126	6	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	facs-Heart-LA-3m-Lymphocytic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMPD1 LRP8 MMP9 KLRC1 KLRC2 KLRC3	8.43e-06	168	126	6	16c3313c4186fa327d71215f8eebc31fc12ff1c0
ToppCell	facs-Heart-LA-3m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMPD1 LRP8 MMP9 KLRC1 KLRC2 KLRC3	8.43e-06	168	126	6	24d1e0a05cda09ee3b80208d75cb2b601023f3bf
ToppCell	facs-Heart-LA-3m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMPD1 LRP8 MMP9 KLRC1 KLRC2 KLRC3	8.43e-06	168	126	6	b952af95a68888adedd03b1b60836d18524611ab
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	USP9Y NALF1 DENND1B PIK3C2G SCN2A SORL1	1.13e-05	177	126	6	c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TUT4 CYTH1 LARS2 KLRC1 KLRC2 KLRC3	1.41e-05	184	126	6	b12fb85a064f715a4f0ada1df8e422c359b573cf
ToppCell	facs-Marrow-T-cells-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TUT4 CYTH1 LARS2 KLRC1 KLRC2 KLRC3	1.46e-05	185	126	6	e1fd0a807def8c2127194108b1a30c6de7024292
ToppCell	Control-Endothelial-Endothelial-Vein\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC19A2 LRP8 PTCHD1 NALF1 TLL1 IL1R1	1.50e-05	186	126	6	92092f11ecce22c14f244e42c499af0822977e6f
ToppCell	RA-10._Endothelium_II\|RA / Chamber and Cluster_Paper	CYTH1 RALGAPA2 ADGRL4 NALF1 TLL1 IL1R1	1.65e-05	189	126	6	c81787a8c662db5d7814c583dd64562857629e81
ToppCell	RA-09._Endothelium_I\|World / Chamber and Cluster_Paper	WARS1 RALGAPA2 ADGRL4 NALF1 TLL1 TSPAN14	1.75e-05	191	126	6	c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCell	RA-09._Endothelium_I\|RA / Chamber and Cluster_Paper	WARS1 RALGAPA2 ADGRL4 NALF1 TLL1 TSPAN14	1.80e-05	192	126	6	8a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CHI3L1 BMP1 PTPN3 NALF1 ATP8A1 SNX25	1.80e-05	192	126	6	cc9911e182a289779a2612bc213daae5607689e7
ToppCell	COPD-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	CYTH1 ELOVL7 ADGRL4 FAP MDN1 IL1R1	1.91e-05	194	126	6	8dcde77767b23e75360adb316cdccf56a00e3726
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK3 SPINT1 SPTSSB ELOVL7 ATP8A1 TLL1	1.91e-05	194	126	6	6b286992d4bb56013c0ea5a7601d3476d806175a
ToppCell	Control-Epithelial-ATII\|Epithelial / Disease state, Lineage and Cell class	NPC1 BMP1 NALF1 ATP8A1 SNX25 IL1R1	1.91e-05	194	126	6	a01de094f7bfd099bcbb2f94224690a2efb887b4
ToppCell	LA-09._Endothelium_I\|World / Chamber and Cluster_Paper	WARS1 RALGAPA2 ADGRL4 NALF1 TLL1 TSPAN14	1.96e-05	195	126	6	fc95457a298b5d0dab687d9ee7e225a7f7b9a0d4
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAPTM4A WARS1 ATP8A2 C1S IL1R1 KLRC3	2.08e-05	197	126	6	2e3d64648a1e4f01b9256a96b94b8a640ee1824c
ToppCell	LA-09._Endothelium_I\|LA / Chamber and Cluster_Paper	WARS1 RALGAPA2 ADGRL4 NALF1 TLL1 TSPAN14	2.08e-05	197	126	6	ab6d1ab586a188597a39854ef980b8955ebcc645
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	DHX36 TUT4 OAS1 OASL KDM2A OGA	2.08e-05	197	126	6	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAPTM4A WARS1 OAS1 LRP1 C1S IL1R1	2.14e-05	198	126	6	09be07ebfc3e49c3858e9b74605b69cf4fc28b56
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	DHX36 TUT4 OAS1 OASL KDM2A OGA	2.14e-05	198	126	6	44417089b62056269cac38d3134ff209c05b7007
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	SLCO3A1 NR6A1 BTBD9 NF1 ATP8A1 SNX25	2.14e-05	198	126	6	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DHX36 TUT4 OAS1 OASL KDM2A OGA	2.14e-05	198	126	6	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	BAL-Severe-cDC_10\|Severe / Compartment, Disease Groups and Clusters	NR6A1 CCNG2 ATP8A1 KDM2B SUCO PDCD1LG2	2.20e-05	199	126	6	54bdadd04abaf8caa948b0177c037bc089ca07e6
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAPTM4A WARS1 OAS1 FAP C1S IL1R1	2.20e-05	199	126	6	137ff58897e6ada8a5a70205f66fe9110795506b
ToppCell	MS-Multiple_Sclerosis-Lymphocyte-T/NK-ILC\|Multiple_Sclerosis / Disease, condition lineage and cell class	SPTSSB BTBD9 USP9Y PTCHD1 RNF123 SNX25	2.26e-05	200	126	6	ab9bdc9365cbdffe4ed246ce0c8a008a390e387e
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_0\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CHI3L1 PRDM7 SHOC1 MMP9 IL1R1	3.19e-05	128	126	5	58639cfdc70ff6764adcc5c1ce9eba9d033b8209
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_0\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CHI3L1 PRDM7 SHOC1 MMP9 IL1R1	3.19e-05	128	126	5	9b3c57d559a5ed8d590dd89b64a57a3227d8c684
ToppCell	PND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RASGEF1C KLRC1 KLRC2 KLRC3 PDCD1LG2	7.02e-05	151	126	5	1525422afadff68a1525ced6d5db45fdea450678
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_D2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DOCK3 SPTSSB NUDT13 HSDL1 KLRC1	7.24e-05	152	126	5	595afcfa8b161e291fcaf2afc7336bac9b6fae0f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM22 PTPN3 NALF1 PIK3C2G SCN2A	7.47e-05	153	126	5	79c4f4ccdc8249c8461075c73491bc3b2d13344a
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_D2\|356C / Donor, Lineage, Cell class and subclass (all cells)	APOBEC3D SPTSSB KLRC1 KLRC2 KLRC3	7.47e-05	153	126	5	5fb7d92cddc816c64071465e955ed0ea3bb45316
ToppCell	IIH-CD8-exh_CD4\|IIH / Condition, Cell_class and T cell subcluster	TRIM26 PTPN3 SNX25 OASL WDR35	7.70e-05	154	126	5	a2f51a3c5455fe2483e438375ea856afce8262fe
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4/8-lo-Trm_Tgd\|lymph-node_spleen / Manually curated celltypes from each tissue	ADAM22 SHQ1 LIMK2 WDR35 KLRC2	7.94e-05	155	126	5	b0e456c4915076e1d38282e116a6eb3230ae80dc
ToppCell	severe_COVID-19-NK_CD56bright\|severe_COVID-19 / disease group, cell group and cell class (v2)	SPTSSB KDM2B KLRC1 KLRC2 KLRC3	8.69e-05	158	126	5	c2e8d96fc29aa2388b92b4fd81d2726e1f7a053f
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DOCK3 ATP8A2 GRIA2 PTCHD1 SCN2A	8.96e-05	159	126	5	7747cef94c55144fddcd024a7495318357f1351b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM22 PTPN3 NALF1 PIK3C2G SCN2A	8.96e-05	159	126	5	50d951cf27a571c0c5002003c16fbc370fa17eb1
ToppCell	368C-Myeloid-Dendritic-cDC_activated\|368C / Donor, Lineage, Cell class and subclass (all cells)	DOCK3 NR6A1 LARS2 CCNG2 KDM2B	9.22e-05	160	126	5	bcd90ef96464bd901b87b94c696de70c113bfd03
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK3 TRIM26 SNX25 KLRC1 KLRC2	9.50e-05	161	126	5	334f540dff3508d451e5e85e8e4e8f3b8d6b74e7
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK3 TRIM26 SNX25 KLRC1 KLRC2	9.50e-05	161	126	5	81d44438e4be4e68a59247e62f02026301a8a0c5
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM22 ATP8A1 PIK3C2G SCN2A SORL1	9.78e-05	162	126	5	36ddebe3bb172c992739353b7b049b2dde98b559
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SGSM1 ADAM22 PIK3C2G SCN2A SHOC1	1.07e-04	165	126	5	9bd332e5ede759a00a47728ea5558c215efdd77a
ToppCell	droplet-Spleen-nan-21m-Myeloid-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPINT1 CHI3L1 PTCHD1 MMP9 SKAP2	1.07e-04	165	126	5	fbd84f211ad645c91b9f45a0815391606f3206ac
ToppCell	droplet-Spleen-nan-21m-Myeloid\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPINT1 CHI3L1 PTCHD1 MMP9 SKAP2	1.07e-04	165	126	5	6fbdfacb49e627712ac999d40ae22dcb390edd3e
ToppCell	droplet-Lung-immune-endo-depleted-3m-Lymphocytic-NK_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RALGAPA2 ELOVL7 ZDHHC15 KLRC1 KLRC2	1.07e-04	165	126	5	93ed399b8c6278e5f1528c07758fb502d80a1a8b
ToppCell	368C-Myeloid-Dendritic-cDC_activated\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	DOCK3 WARS1 NR6A1 LARS2 CCNG2	1.07e-04	165	126	5	9d2bdc42c13c8c2a68889bec8612a1ce56f659fa
ToppCell	droplet-Lung-3m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l15\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	THNSL1 SPINT1 NR6A1 ATP13A2 DCLRE1C	1.07e-04	165	126	5	1d0f60bf47a40ac916f0fcb5532a968742a0edbb
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	WARS1 RALGAPA2 ADGRL4 NALF1 TLL1	1.10e-04	166	126	5	f7926ee266dcbf10df375cd921f1db5a2fa604f8
ToppCell	droplet-Lung-immune-endo-depleted-3m-Lymphocytic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RALGAPA2 ELOVL7 ZDHHC15 KLRC1 KLRC2	1.10e-04	166	126	5	3213466380becf0ee3d4d9a0776ccbb1ee4eccea
ToppCell	facs-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IMPG1 SPINT1 RYR1 PTCHD1 PRDM9	1.13e-04	167	126	5	fd84a99ea142d1684cdcf4a88ef1d541760bc78a
ToppCell	390C-Lymphocytic-ILC-ILC-2\|390C / Donor, Lineage, Cell class and subclass (all cells)	MIER2 APOBEC3D RNF123 OASL KLRC2	1.16e-04	168	126	5	2781dd6b369427a94c5059b44b4c8f023f5f2988
ToppCell	facs-Liver-Non-hepatocytes-24m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MMP9 KLRC1 KLRC2 KLRC3 PDCD1LG2	1.16e-04	168	126	5	1254c66f0cd53ef3b913933c0b0648d091da07e9
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	EREG RYR1 MMP9 IL1R1 PROC	1.19e-04	169	126	5	a0681317867e31319210a23e56660a53f4529efe
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	THNSL1 SLC19A2 RNF175 USP9Y RYR1	1.19e-04	169	126	5	e3100eb587005e160bd0b7990fa57ec49765133d
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	OAS1 BTBD9 RALGAPA2 OASL PDCD1LG2	1.23e-04	170	126	5	07b561cd9c528bc8444c9385e1de621eee7b697e
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-Tuft-related\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPINT1 SPTSSB LGALS14 PROC SORL1	1.26e-04	171	126	5	042701dd87676d41d8e7e7cce0e1ffc2331b248d
ToppCell	COVID-19_Severe-NK_CD56bright\|COVID-19_Severe / Disease condition and Cell class	SPTSSB CCNG2 SKAP2 KLRC1 KLRC2	1.26e-04	171	126	5	5810f790012a0750ca3378595514f66a99f123be
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPINT1 SPTSSB LGALS14 PROC SORL1	1.26e-04	171	126	5	74d7811a57837d99932a9b86f2d08e8574a819e6
ToppCell	severe_influenza-Neutrophil\|severe_influenza / disease group, cell group and cell class (v2)	CHI3L1 LIMK2 LRP6 MMP9 SORL1	1.33e-04	173	126	5	615e266419b9f06e964eff73cb466f05451ba0dd
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Tall_Cell\|TCGA-Thryoid / Sample_Type by Project: Shred V9	NPC1 SPINT1 TBC1D2 CHI3L1 FAP	1.33e-04	173	126	5	2e9dc137f3675eee07f941eb4cfcaf24a83ab0fb
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO1 APOBEC3B ADGRL4 TLL1 PDCD1LG2	1.40e-04	175	126	5	90302e8a44858ef3b2a165b88284d4788d591a99
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Adult / Lineage, Cell type, age group and donor	DOCK3 ATP8A2 GRIA2 NALF1 RHBDL3	1.40e-04	175	126	5	4db1a3c284488b3f6de7568363f176d74e2a4587
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231\|Adult / Lineage, Cell type, age group and donor	DOCK3 ATP8A2 GRIA2 NALF1 RHBDL3	1.40e-04	175	126	5	8d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCell	facs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHA6 BMP1 FAP C1S IL1R1	1.44e-04	176	126	5	fee4e0f32aaf77294040c7af6c1f503571750d43
ToppCell	facs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHA6 BMP1 FAP C1S IL1R1	1.44e-04	176	126	5	f25251abd4ef9fb077a978f9f9f658af58e4e0d2
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	FBXW4 ADAM22 CRY2 MDN1 OGA	1.48e-04	177	126	5	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	15-Airway-Immune-Hematopoietic,_Natural_Killer_Cell\|Airway / Age, Tissue, Lineage and Cell class	APOBEC3B OASL MMP9 KLRC1 KLRC2	1.52e-04	178	126	5	0003c3f2561b7a1fd86772bcba59883ba1f17cd2
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPC1 EREG CHI3L1 TBCK C1S	1.56e-04	179	126	5	e880c507f11ce75d104593a4ca29f0295f8125e8
ToppCell	COVID-19-Heart-Lymph_EC\|Heart / Disease (COVID-19 only), tissue and cell type	PIEZO1 RALGAPA2 NALF1 TLL1 SKAP2	1.56e-04	179	126	5	411620201a860716a8773b92f50f7b94ef34a586
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAM22 ELOVL7 NALF1 PIK3C2G SCN2A	1.56e-04	179	126	5	666072c0e8448dbaec1683d18368ec2502453f90
ToppCell	10x3'2.3-week_17-19-Lymphocytic_NK-T_NK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SPTSSB SLCO3A1 KLRC1 KLRC2 KLRC3	1.60e-04	180	126	5	0a98d21fec67a890e75ebf0e2d23adddd77da214
ToppCell	10x3'2.3-week_17-19-Lymphocytic_NK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SPTSSB SLCO3A1 KLRC1 KLRC2 KLRC3	1.60e-04	180	126	5	1c8398342d3fa4d5ca9a8a63626cc497c5291446
ToppCell	10x3'2.3-week_17-19-Lymphocytic_NK-T_NK-CD56_bright_NK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SPTSSB SLCO3A1 KLRC1 KLRC2 KLRC3	1.60e-04	180	126	5	ddbab26b05f057bd78b78773381cd447bd2e2726
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-4\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	ATP8A2 ADAM22 RHBDL3 LRP6 TOR3A	1.60e-04	180	126	5	886ebaf9cf8992e8dd13fca799a1d1a2a9ce73d8
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SGSM1 ADGRL4 NALF1 TLL1 SKAP2	1.73e-04	183	126	5	c1297d8eddfc7132e84ceef14f01b6281f9d0f6a
ToppCell	CF-Myeloid-Neutrophil\|CF / Disease state, Lineage and Cell class	TBC1D2 RALGAPA2 LIMK2 IL1R1 SORL1	1.73e-04	183	126	5	da43827952e6fdee2ce94648c316182f272b321c
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NR6A1 PTPN3 PTCHD1 NALF1 ATP8A1	1.77e-04	184	126	5	102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NR6A1 PTCHD1 NALF1 ATP8A1 LRP6	1.82e-04	185	126	5	98b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell	10x3'2.3-week_12-13-Mesenchymal_myocytic-stroma-muscle\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FBXW4 BTBD9 CRY2 BMP1 KLRC2	1.82e-04	185	126	5	0094f9baddb20214d2a2c166f1637d1a9cf1169a
ToppCell	AT2_cells-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	ATP8A2 CHI3L1 BMP1 NALF1 SNX25	1.82e-04	185	126	5	3b3268e3f99121124e33086cac88479808d31630
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SGSM1 ATP8A2 MDN1 ATP8A1 TLL1	1.82e-04	185	126	5	bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCell	(1)_Control_(PBS)-(2)_LEPR+_perivascular_cells_and_VE-Cad+_vascular_cells_(mixed)\|World / Stress and Cell class	LAPTM4A BMP1 FAP LRP1 IL1R1	1.82e-04	185	126	5	b8cd94cf18308b514fc61557550225794ffd2860
ToppCell	COVID-19_Moderate-NK_activated\|World / disease group, cell group and cell class	OAS1 OASL KLRC1 KLRC2 KLRC3	1.86e-04	186	126	5	ff8f32f69516bf785224fa12f8139a95359b0279
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	COQ3 ARMCX2 RYR1 WDR35 MMP9	1.86e-04	186	126	5	74eb69a52090f9e2426a47e03a1c478ee0cfec18
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_vein\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RALGAPA2 ADGRL4 NALF1 TLL1 IL1R1	1.91e-04	187	126	5	e35716f8b482be3bf5ab79f087a9caf67a9d197a
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_3\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	COQ3 ARMCX2 RYR1 WDR35 MMP9	1.91e-04	187	126	5	1eed2c1a05e80a7c8f639437c117afe0c18dfb0c
ToppCell	COVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	RALGAPA2 ADGRL4 NALF1 TLL1 IL1R1	1.91e-04	187	126	5	2d20193a6cacdfa4877457c97b0077408942186c
ToppCell	droplet-Lung-LUNG-1m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SGSM1 ATP8A2 SLCO3A1 ZDHHC15 TLL1	1.91e-04	187	126	5	9c9ae8725905ba0cfe407878006ed06c2480fb72
ToppCell	droplet-Lung-LUNG-1m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SGSM1 ATP8A2 SLCO3A1 ZDHHC15 TLL1	1.91e-04	187	126	5	9e9460e57cdc9cd0a0de2866b140e06d0bc19a8f
ToppCell	Control-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	CYTH1 ELOVL7 ADGRL4 BMP1 FAP	1.91e-04	187	126	5	5429ae85942b8ec3895cceb63c663de3c24ca064
ToppCell	5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CHD8 ELOVL7 ADGRL4 FAP TLL1	1.96e-04	188	126	5	524d1d928c9386acf20e53d31894107dd7290dc7
ToppCell	droplet-Lung-1m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SGSM1 ATP8A2 SLCO3A1 ZDHHC15 TLL1	1.96e-04	188	126	5	dc52dd2957be3f40001f0a56f3d9ac9d66ea466e
ToppCell	5'-Airway_Nasal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CHD8 ELOVL7 ADGRL4 FAP TLL1	1.96e-04	188	126	5	1b57995d70cf81212e8d46dfaf44dbaf9c7bc4d5
ToppCell	COVID-19-lung-Vein_EC\|lung / Disease (COVID-19 only), tissue and cell type	RALGAPA2 ADGRL4 NALF1 TLL1 IL1R1	1.96e-04	188	126	5	d582b76fc2faac526c9bf97503041129e1a6a211
ToppCell	5'-Airway_Nasal-Endothelial-Blood_vessel_EC\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CHD8 ELOVL7 ADGRL4 FAP TLL1	1.96e-04	188	126	5	cd2d1f8e43c252dd8730a5758458ef63e7ffc836
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SGSM1 ELOVL7 NALF1 PIK3C2G SCN2A	1.96e-04	188	126	5	eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCell	COVID-19-kidney-DCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ELOVL7 PTPN3 NALF1 PIK3C2G SCN2A	1.96e-04	188	126	5	1d56cd409793f05cca20757ab26e91f1a1ee67b5
Drug	beta-hydroxyasparagine	EREG ADGRL4 SCN2A C1S PROC	2.19e-06	39	124	5	CID000152191
Drug	Protriptyline hydrochloride [1225-55-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A	OAS1 NR6A1 ADAM22 CCNG2 BMP1 NF1 NALF1 OASL	8.71e-06	187	124	8	5438_UP
Drug	Metyrapone [54-36-4]; Up 200; 17.6uM; MCF7; HT_HG-U133A	NR6A1 HHLA1 ADAM22 CCNG2 LIMK2 NF1 OGA PROC	1.02e-05	191	124	8	5667_UP
Drug	Sulmazole [73384-60-8]; Up 200; 14uM; PC3; HT_HG-U133A	TUT4 IMPG1 CYTH1 CHI3L1 CRY2 PRDM9 ATP8A1 OGA	1.27e-05	197	124	8	4009_UP
Drug	Dimethadione [695-53-4]; Down 200; 31uM; MCF7; HT_HG-U133A	CYTH1 PTPN21 ADAM22 CCNG2 BMP1 OASL LRP6 OGA	1.27e-05	197	124	8	5668_DN
Drug	ICI182,780; Up 200; 1uM; MCF7; HT_HG-U133A	TBC1D2 OAS1 PLEKHA6 CRY2 CCNG2 BMP1 NF1 IL1R1	1.37e-05	199	124	8	6872_UP
Drug	Fenspiride hydrochloride [5053-08-7]; Up 200; 13.4uM; PC3; HT_HG-U133A	TUT4 SLCO3A1 PTPN21 NUDT13 BMP1 LIMK2 LRP1 IL1R1	1.37e-05	199	124	8	7298_UP
Drug	alpha-Santonin [481-06-1]; Up 200; 16.2uM; PC3; HT_HG-U133A	ATP8A2 LGALS14 SLCO3A1 HHLA1 RYR1 NF1 OASL FZD10	1.42e-05	200	124	8	3795_UP
Drug	AC1L1AGT	WARS1 OAS1 LARS2 RYR1 NF1 OASL	3.28e-05	111	124	6	CID000000982
Drug	Mifepristone [84371-65-3]; Up 200; 9.4uM; MCF7; HT_HG-U133A	OAS1 PTPN21 NUDT13 CCNG2 BMP1 LIMK2 OASL	7.55e-05	187	124	7	7183_UP
Drug	17alpha-estradiol	EREG WARS1 PSEN1 OAS1 CAV3 APOBEC3B ADGRL4 LRP8 CCNG2 PIK3C2G LRP1 LRP6 FZD10 MMP9 IL1R1 SKAP2 KLRC1 PROC SORL1	8.02e-05	1303	124	19	CID000000450
Drug	Sulconazole nitrate [61318-91-0]; Up 200; 8.6uM; MCF7; HT_HG-U133A	AMPD1 OAS1 NR6A1 PTPN21 BMP1 OASL OGA	8.07e-05	189	124	7	4998_UP
Drug	Apigenin [520-36-5]; Down 200; 14.8uM; MCF7; HT_HG-U133A	OAS1 CCNG2 NF1 OASL MMP9 IL1R1 SKAP2	8.07e-05	189	124	7	4401_DN
Drug	Desipramine hydrochloride [58-28-6]; Up 200; 13.2uM; PC3; HT_HG-U133A	OAS1 RYR1 ACOX3 CCNG2 ATP8A1 OASL C1S	8.62e-05	191	124	7	6693_UP
Drug	Trihexyphenidyl-D,L Hydrochloride [58947-95-8]; Up 200; 11.8uM; MCF7; HT_HG-U133A	CAV3 USP9Y ADAM22 CRY2 CCNG2 NF1 NALF1	9.20e-05	193	124	7	4133_UP
Drug	Rapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A	CYTH1 PTPN21 NUDT13 CRY2 CCNG2 NF1 SORL1	9.20e-05	193	124	7	6981_UP
Drug	CP-645525-01 [287190-82-3]; Down 200; 10uM; MCF7; HT_HG-U133A	TBC1D2 SLCO3A1 ATP13A2 FAP SEC23IP LRP6 OGA	9.51e-05	194	124	7	7515_DN
Drug	Picrotoxinin [17617-45-7]; Up 200; 13.6uM; PC3; HT_HG-U133A	ADAM22 RYR1 PRDM9 NF1 ATP8A1 IL1R1 PROC	9.51e-05	194	124	7	4260_UP
Drug	Mefexamide hydrochloride [3413-64-7]; Up 200; 12.6uM; PC3; HT_HG-U133A	OAS1 PTPN21 ACOX3 OASL PCIF1 LRP6 MMP9	9.82e-05	195	124	7	2121_UP
Drug	Meclozine dihydrochloride [1104-22-9]; Down 200; 8.6uM; HL60; HT_HG-U133A	CYTH1 CRY2 BMP1 LIMK2 NF1 LRP6 KDM2A	1.01e-04	196	124	7	2424_DN
Drug	AG-013608 [351320-38-2]; Up 200; 10uM; PC3; HT_HG-U133A	CCNG2 NF1 SEC23IP OASL LRP1 IL1R1 OGA	1.05e-04	197	124	7	5949_UP
Drug	Dropropizine (R,S) [17692-31-8]; Up 200; 17uM; PC3; HT_HG-U133A	THNSL1 NR6A1 ACOX3 BMP1 PRDM9 LRP1 C1S	1.05e-04	197	124	7	5106_UP
Drug	ICI 182,780; Up 200; 1uM; MCF7; HT_HG-U133A	TBC1D2 PLEKHA6 HHLA1 CRY2 CCNG2 NF1 IL1R1	1.05e-04	197	124	7	5202_UP
Drug	Bepridil hydrochloride [74764-40-2]; Down 200; 10uM; PC3; HT_HG-U133A	PSEN1 U2SURP PLEKHA6 PTPN21 CCNG2 LIMK2 ATP8A1	1.05e-04	197	124	7	4613_DN
Drug	Bezafibrate [41859-67-0]; Up 200; 11uM; PC3; HT_HG-U133A	EREG CYTH1 ADAM22 SCN2A LRP1 MMP9 OGA	1.05e-04	197	124	7	6653_UP
Drug	Idazoxan hydrochloride [79944-56-2]; Up 200; 16.6uM; PC3; HT_HG-U133A	DIPK1A ATP8A2 OAS1 ADAM22 RYR1 NF1 LRP1	1.05e-04	197	124	7	6747_UP
Drug	Milrinone [78415-72-2]; Up 200; 19uM; PC3; HT_HG-U133A	CYTH1 LIMK2 LRP1 LRP6 IL1R1 OGA PROC	1.08e-04	198	124	7	5856_UP
Drug	Diethylstilbestrol [56-53-1]; Down 200; 15uM; MCF7; HT_HG-U133A	MIER2 NR6A1 ADAM22 CRY2 BMP1 LIMK2 NF1	1.08e-04	198	124	7	3895_DN
Drug	Corynanthine hydrochloride [66634-44-4]; Up 200; 10.2uM; MCF7; HT_HG-U133A	MIER2 TBC1D2 NUDT13 CRY2 NF1 NALF1 FZD10	1.08e-04	198	124	7	4811_UP
Drug	2-propylpentanoic acid; Up 200; 50uM; PC3; HT_HG-U133A	TUT4 OAS1 ARMCX2 BMP1 LIMK2 OASL OGA	1.08e-04	198	124	7	1222_UP
Drug	Nialamide [51-12-7]; Up 200; 13.4uM; PC3; HT_HG-U133A	IMPG1 CYTH1 PTPN21 ACOX3 TLL2 LRP1 IL1R1	1.08e-04	198	124	7	4525_UP
Drug	Gabexate mesilate [56974-61-9]; Up 200; 9.6uM; MCF7; HT_HG-U133A	TBC1D2 PTPN21 LARS2 ADAM22 NF1 OASL IL1R1	1.08e-04	198	124	7	7357_UP
Drug	S(-)Eticlopride hydrochloride [97612-24-3]; Up 200; 10.6uM; MCF7; HT_HG-U133A	MIER2 DOCK3 NR6A1 ADAM22 OASL C1S MMP9	1.08e-04	198	124	7	3393_UP
Drug	Iodipamide [606-17-7]; Up 200; 3.6uM; PC3; HT_HG-U133A	ATP8A2 OAS1 ADAM22 CRY2 BMP1 NF1 LRP1	1.11e-04	199	124	7	5085_UP
Drug	Propylthiouracil [51-52-5]; Up 200; 23.4uM; MCF7; HT_HG-U133A	MIER2 ADCY10 NR6A1 USP9Y FZD10 IL1R1 OGA	1.11e-04	199	124	7	4157_UP
Drug	Amethopterin (R,S) [59-05-2]; Up 200; 8.8uM; PC3; HT_HG-U133A	OAS1 ARMCX2 ADAM22 BMP1 SCN2A OGA PROC	1.11e-04	199	124	7	6654_UP
Drug	nordihydroguaiaretic acid; Down 200; 1uM; MCF7; HT_HG-U133A	MIER2 THNSL1 CRY2 LIMK2 NF1 IL1R1 SORL1	1.11e-04	199	124	7	1648_DN
Drug	Pipemidic acid [51940-44-4]; Up 200; 13.2uM; MCF7; HT_HG-U133A	MIER2 CYTH1 ADAM22 ADGRL4 NF1 OASL FZD10	1.15e-04	200	124	7	6470_UP
Drug	Vitexin [3681-93-4]; Down 200; 9.2uM; MCF7; HT_HG-U133A	THNSL1 OAS1 PLEKHA6 PTPN21 NF1 BPHL OASL	1.15e-04	200	124	7	4413_DN
Drug	beta-hydroxyaspartic acid	EREG ADGRL4 C1S PROC	1.25e-04	47	124	4	CID000005425
Disease	attention deficit hyperactivity disorder (implicated_via_orthology)	ADGRL4 PTCHD1 NF1	2.00e-04	28	120	3	DOID:1094 (implicated_via_orthology)
Disease	peak expiratory flow	ATP13A2 NALF1 TBCK RASGEF1C LRP1 KDM2A SKAP2 PROC SORL1	2.07e-04	498	120	9	EFO_0009718
Disease	myocardial infarction (is_marker_for)	CHI3L1 MMP9 PROC	3.27e-04	33	120	3	DOID:5844 (is_marker_for)
Disease	temporal arteritis (is_marker_for)	CHI3L1 MMP9	3.40e-04	7	120	2	DOID:13375 (is_marker_for)
Disease	squamous cell lung carcinoma, family history of lung cancer	BTBD9 NF1 NALF1 PROC	4.09e-04	85	120	4	EFO_0000708, EFO_0006953
Disease	programmed cell death 1 ligand 2 measurement	DHX36 PDCD1LG2	4.52e-04	8	120	2	EFO_0008268
Disease	Intellectual Disability	ATP8A2 GRIA2 CHD8 ATL1 PTCHD1 NF1 LNPK ASCC3	4.99e-04	447	120	8	C3714756
Disease	thioredoxin domain-containing protein 12 measurement	DOCK3 TUT4 RNF123	5.39e-04	39	120	3	EFO_0008298
Disease	amyloid-beta measurement	LCLAT1 RYR1 CCNG2 NALF1 SHOC1 LNPK SORL1	6.40e-04	355	120	7	EFO_0005194
Disease	lung non-small cell carcinoma (is_marker_for)	CHI3L1 FAP NF1 KDM2A MMP9	6.51e-04	169	120	5	DOID:3908 (is_marker_for)
Disease	hereditary spastic paraplegia (implicated_via_orthology)	ATP13A2 ATL1 SEC23IP	7.19e-04	43	120	3	DOID:2476 (implicated_via_orthology)
Disease	cholesteatoma (is_marker_for)	EREG MMP9	7.23e-04	10	120	2	DOID:869 (is_marker_for)
Disease	coronary artery disease (is_implicated_in)	AMPD1 LRP8 TLL1 MMP9	7.55e-04	100	120	4	DOID:3393 (is_implicated_in)
Disease	glioblastoma (is_marker_for)	CHI3L1 ADGRL4 MMP9	7.69e-04	44	120	3	DOID:3068 (is_marker_for)
Disease	attention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia	TRIM26 ADGRL4 NALF1 IL1R1	7.84e-04	101	120	4	EFO_0003756, EFO_0003761, EFO_0003888, MONDO_0004985, MONDO_0005090
Disease	serum ST2 measurement	DENND1B IL1R1	8.81e-04	11	120	2	EFO_0005416
Disease	N-acetylmethionine measurement	DOCK3 SLCO3A1	1.66e-03	15	120	2	EFO_0021427
Disease	thrombosis (is_implicated_in)	MMP9 PROC	1.66e-03	15	120	2	DOID:0060903 (is_implicated_in)
Disease	cholesteatoma of middle ear (is_marker_for)	MMP9 IL1R1	1.90e-03	16	120	2	DOID:10964 (is_marker_for)
Disease	Alzheimer's disease (is_implicated_in)	PSEN1 LRP8 LRP1 SORL1	2.11e-03	132	120	4	DOID:10652 (is_implicated_in)
Disease	hypertrophic cardiomyopathy (is_marker_for)	ADGRL4 MMP9	2.14e-03	17	120	2	DOID:11984 (is_marker_for)
Disease	bitter alcoholic beverage consumption measurement	NPC1 NF1 NALF1 SORL1	2.16e-03	133	120	4	EFO_0010092
Disease	Profound Mental Retardation	CHD8 PTCHD1 NF1 ASCC3	2.54e-03	139	120	4	C0020796
Disease	Mental Retardation, Psychosocial	CHD8 PTCHD1 NF1 ASCC3	2.54e-03	139	120	4	C0025363
Disease	Mental deficiency	CHD8 PTCHD1 NF1 ASCC3	2.54e-03	139	120	4	C0917816
Disease	age-related macular degeneration, COVID-19	OAS1 DENND1B MMP9	2.83e-03	69	120	3	EFO_0001365, MONDO_0100096
Disease	Schizophrenia	GRIA2 PLEKHA6 PTPN21 CHI3L1 BTBD9 LARS2 LRP8 LRP1 KDM2B MMP9	3.29e-03	883	120	10	C0036341
Disease	obsolete_red blood cell distribution width	PSEN1 DIPK1A CYTH1 PIEZO1 U2SURP APOBEC3B ADGRL4 LIMK2 RNF123 DENND1B PCIF1 KDM2B C1S	3.34e-03	1347	120	13	EFO_0005192
Disease	Alzheimer disease, educational attainment	NPC1 DOCK3 ELOVL7 OGA SORL1	3.45e-03	247	120	5	EFO_0011015, MONDO_0004975
Disease	prostate carcinoma (is_marker_for)	SPINT1 CHI3L1	3.92e-03	23	120	2	DOID:10286 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
KVTDRYRSLCAFWNY	ADGRL4	361	Q9HBW9
YYLVKWCSLPYEDST	CHD8	746	Q9HCK8
ILYGRSYTWLCYEVK	APOBEC3D	26	Q96AK3
ILYGRSYTWLCYEVK	APOBEC3B	26	Q9UH17
SAVALAAYKWLVCYL	ACOX3	511	O15254
AAYKWLVCYLLRETY	ACOX3	516	O15254
YRTIWFKSYRTIFSC	COQ3	56	Q9NZJ6
EWACKLYITFVFLSY	GPR32	111	O75388
YIWGQKVTASDKYCY	ADAM22	556	Q9P0K1
FFYWRELVSKCLAEY	CCNG2	241	Q16589
AYRYETWCYELNLIA	AMPD1	726	P23109
CLSLLWRIYSYSYLF	ADCY10	1211	Q96PN6
SLDLYRSRLCWYDYV	BMP1	366	P13497
EDRFWTCAYRLYYAL	BBS12	516	Q6ZW61
WYCVYKYTRGRDQTK	ARMCX2	21	Q7L311
YCFYKNIVLYIIEIW	ATP8A1	861	Q9Y2Q0
YCFYKNVVLYIIELW	ATP8A2	881	Q9NTI2
EEWITYSNSCYYIGK	KLRC1	121	P26715
YSNSCYYIGKERRTW	KLRC1	126	P26715
QCIIIYGVAWDYKYL	PDCD1LG2	101	Q9BQ51
EEKKRYLWFYRFYCN	PIK3C2G	671	O75747
VAVYRKYICTSFYPW	PTPN3	241	P26045
QYREKAYFCQDRFYW	MMP9	666	P14780
KDSLCSVLWNLYHYY	MDN1	3906	Q9NU22
SLTNWYYEKDGKLYC	LIMK2	46	P53671
YYRLRVCQEAVWEAY	IMPG1	96	Q17R60
KAYLINCVWNCYKYI	LAPTM4A	176	Q15012
LVSRLVYWADAYLDY	LRP1	376	Q07954
CLLIYLYSLVKWYFI	LCLAT1	361	Q6UWP7
AYKLVCYYTSWSQYR	CHI3L1	21	P36222
GSFLWYLYLDKIYCL	EFCAB9	6	A8MZ26
LLSLIEYYQWDKFAY	GRIA2	136	P42262
RYKWLRFSEDCLYLN	CES4A	106	Q5XG92
RYLKICYLSYGVWLK	OPN5	131	Q6U736
CYLSYGVWLKRKHAY	OPN5	136	Q6U736
RWFILTDNCLYYFEY	CYTH1	281	Q15438
IDIYSRYIYWTCEAT	LRP6	1021	O75581
SYSLWRSKSVYYRVY	ACBD3	511	Q9H3P7
ECVAFYYMWKKSERY	MIER3	316	Q7Z3K6
LVINYQQLCIYWTKY	OAS1	261	P00973
CYLYELWYKLAKIRD	RALGAPA2	956	Q2PPJ7
RKFFWCYRLLSTYVT	NUDT13	11	Q86X67
EVICIYWTKYYTLHN	OASL	271	Q15646
LELREVTYFSLWYYN	PTPN21	56	Q16825
AFFAVWCYRKRYFVS	NPC1	286	O15118
WCYRKRYFVSEYTPI	NPC1	291	O15118
YSWLITKGRNCYEYV	PRDM9	291	Q9NQV7
NYGVYTKVSRYLDWI	PROC	431	P04070
CYFYERLNMDYWKIL	FZD10	461	Q9ULW2
YYWYALCIFLISSIS	ATP13A2	256	Q9NQ11
NDYIYLSWLARCYIM	TTC26	426	A0AVF1
EMCWYVLERYVYCIT	KDM2A	331	Q9Y2K7
EMCWYVLERYVYCVT	KDM2B	361	Q8NHM5
ITLCTWAYIRYSGEY	ATL1	486	Q8WXF7
VVWLNCKAAYGYEYL	DCLRE1C	201	Q96SD1
RNYFSKLWLLYRYSC	PCIF1	441	Q9H4Z3
YESLYDYQSLSWIRK	DOCK3	1321	Q8IZD9
CRLFYYRLWDLYKKV	CRY2	281	Q49AN0
TCWLYYFSKFIELLD	ELOVL7	116	A1L3X0
YEKDYCWEYFLSSNT	DHX36	776	Q9H2U1
LYSLYCFEYRWFNKG	EI24	211	O14681
TYGLYTRVKNYVDWI	C1S	661	P09871
DSLVDYYFLCYRDTW	C19orf67	251	A6NJJ6
FTRVYWNRSYFVYKI	DPY19L4	701	Q7Z388
SYTTFTVSKYWCYRL	CAV3	61	P56539
TLLSCGYDTYVRYWD	FBXW4	306	P57775
ITVVGSTYYFCRWYR	EREG	131	O14944
STYYFCRWYRNRKSK	EREG	136	O14944
WYTARKSITVICDFY	HSDL1	31	Q3SXM5
LLLWDCDDRSYSYYV	BTBD9	486	Q96Q07
LYGYDYFARTCEKWV	BPHL	196	Q86WA6
WIIYVQYSTYTELCR	DIPK1A	41	Q5T7M9
CILSYLPWFEVYYKL	DENND1B	96	Q6P3S1
QCYLLVYYTGWRNVK	SEC22A	241	Q96IW7
IWVCYASYVVFRIIY	SLC19A2	386	O60779
LKLLTNHYERCWKYY	RYR1	2641	P21817
YLLRLQESISDFYWY	RYR1	3921	P21817
IDIVLWYRDSCYDFL	IL1R1	361	P14778
TNRIYWCDLSYRKIY	LRP8	461	Q14114
WCDLSYRKIYSAYMD	LRP8	466	Q14114
TRSVGECVEYYYLWK	MIER2	331	Q8N344
ECVEYYYLWKKSERY	MIER2	336	Q8N344
KRYWYICQDFTEYKY	NR6A1	416	Q15406
YLWKDLTLDQAYSYA	WARS1	201	P23381
TEDMRYCLEYYSWFL	HHLA1	486	C9JL84
RYIFADAYAQYLWIT	SORL1	176	Q92673
TTCSKLAYYYQRKGW	SRP54	116	P61011
LAYYYQRKGWKTCLI	SRP54	121	P61011
VVLYKYRCYKVIHAW	PSEN1	151	P49768
YTTTWQCLRKNYKRY	SLCO3A1	641	Q9UIG8
LYKSSLCWYDYIEVR	TLL1	396	O43897
TCLPDYYKWTQYLFI	LARS2	176	Q15031
CANRTILYDMYSYVW	OGA	631	O60502
WITYSNSCYYIGKER	KLRC2	121	P26717
REIDRKWYYDSYTCC	RHBDL3	146	P58872
KEVFDYSYRDYILSW	SNX25	6	Q9H3E2
WCALSKTVFYYYGSD	SKAP2	141	O75563
FLKRYYCDWITNTYV	PTCHD1	486	Q96NR3
YSWLITKGRNCYEYV	PRDM7	291	Q9NQW5
LSLQYRYCWIILYTK	SHOC1	946	Q5VXU9
YILNDLYISDYCVWI	SHQ1	376	Q6PI26
SWLYYQYQIISCCAV	SPTSSB	11	Q8NFR3
SSYKLCTSWNRYLYF	MTRES1	31	Q9P0P8
WITYSNSCYYIGKER	KLRC3	121	Q07444
VYLYDRIRKAAYWEE	SEC23IP	321	Q9Y6Y8
VYYRWKLYSILQGDS	U2SURP	471	O15042
EEAVKWISYTYLYVR	ASCC3	911	Q8N3C0
AREYIYCLYWSTLTL	CNGA2	321	Q16280
FVYLESDYSKLWRYS	FAP	111	Q12884
WFVLVDRCLFYYKDE	PLEKHA6	81	Q9Y2H5
DTWYYAKRCFLSLLE	TTC30B	581	Q8N4P2
LISALRYYWDEYKAS	RNF123	561	Q5XPI4
WYYDPTEQICKSFVY	SPINT1	266	O43278
YVKWFNRLCYLVATE	RASGEF1C	251	Q8N431
VYKWFLLIYKLSYAF	RNF175	136	Q8N4F7
KLISLRYYYFTIGWN	SCN2A	1581	Q99250
SRLCWYDYVEVRDGY	TLL2	401	Q9Y6L7
AVYIYNCNSWVREYT	NF1	1676	P21359
QYYKKWYDARVFCES	THNSL1	191	Q8IYQ7
INCTSSKTLYGLYWY	TRAV34	41	A0A0B4J273
YFCYRWFLLDFKREL	SGSM1	1051	Q2NKQ1
DWKCVTYTSLYKSAY	TRIM26	331	Q12899
ELLWQVAYSYTYELR	USP9Y	2321	O00507
EYIYKWCSVRVALYR	SUCO	631	Q9UBS9
YLAERSIEEVYYLWC	TBCK	316	Q8TEA7
SCVFGIWRYEEKCYY	LGALS14	66	Q8TCE9
DTWYYAKRCFLSLLE	TTC30A	581	Q86WT1
YSNAKVSCWYKYLLF	TSPAN14	6	Q8NG11
VSCWYKYLLFSYNII	TSPAN14	11	Q8NG11
LVKGVYAKYWIYVCA	PIEZO1	571	Q92508
RYLDLLTTWYCSFKD	TOR3A	96	Q9H497
KWGYCSNTVVYAYTR	WDR35	336	Q9P2L0
LVLAFRYWAKLCYID	TUT4	496	Q5TAX3
YLKTSDRCLAWLAYI	ZFC3H1	1516	O60293
YYANKILTLWNIYAC	TMEM14EP	76	Q6UXP3
SRWFFYDERKCQLYY	TBC1D2	66	Q9BYX2
VVLWSYYAYVFELCL	ZDHHC15	31	Q96MV8
SVLYLFTCLIVYLWY	LNPK	51	Q9C0E8
IVYKAWLCSQYFEVT	NALF1	306	B1AL88