Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	ubiquitin-dependent protein catabolic process via the N-end rule pathway	UBR2 UBR3	1.67e-05	4	35	2	GO:0071596
GeneOntologyBiologicalProcess	regulation of protein localization to cell surface	SNX33 ACTN2 EGF	8.81e-05	51	35	3	GO:2000008
Domain	EF-hand_Ca_insen	ACTN2 SPTAN1	5.09e-05	6	35	2	IPR014837
Domain	EFhand_Ca_insen	ACTN2 SPTAN1	5.09e-05	6	35	2	PF08726
Domain	zf-UBR	UBR2 UBR3	7.12e-05	7	35	2	PF02207
Domain	Znf_UBR	UBR2 UBR3	7.12e-05	7	35	2	IPR003126
Domain	ZnF_UBR1	UBR2 UBR3	7.12e-05	7	35	2	SM00396
Domain	ZF_UBR	UBR2 UBR3	7.12e-05	7	35	2	PS51157
Domain	Spectrin	ACTN2 SPTAN1	8.42e-04	23	35	2	PF00435
Domain	Spectrin_repeat	ACTN2 SPTAN1	1.34e-03	29	35	2	IPR002017
Domain	Spectrin/alpha-actinin	ACTN2 SPTAN1	1.63e-03	32	35	2	IPR018159
Domain	SPEC	ACTN2 SPTAN1	1.63e-03	32	35	2	SM00150
Domain	PX	SNX33 PIK3C2G	3.07e-03	44	35	2	SM00312
Domain	PX	SNX33 PIK3C2G	3.80e-03	49	35	2	PF00787
Domain	PX	SNX33 PIK3C2G	3.95e-03	50	35	2	PS50195
Domain	-	SNX33 PIK3C2G	4.11e-03	51	35	2	3.30.1520.10
Domain	Phox	SNX33 PIK3C2G	4.27e-03	52	35	2	IPR001683
Pubmed	Tex19.1 inhibits the N-end rule pathway and maintains acetylated SMC3 cohesin and sister chromatid cohesion in oocytes.	UBR2 UBR3	5.90e-06	4	35	2	32232464
Pubmed	Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway.	UBR2 UBR3	1.47e-05	6	35	2	10805755
Pubmed	Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.	UBR2 UBR3	2.06e-05	7	35	2	21816346
Pubmed	Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear.	PRICKLE2 SPTAN1	2.06e-05	7	35	2	17376975
Pubmed	Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.	UBR2 UBR3	3.53e-05	9	35	2	17855541
Pubmed	Agrin has a pathological role in the progression of oral cancer.	ACTN2 NT5C1B SPTAN1 SACM1L	4.56e-05	197	35	4	29872149
Pubmed	HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.	UBR2 UBR3	6.45e-05	12	35	2	17360488
Pubmed	The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1.	ULK1 SACM1L	8.89e-05	14	35	2	31806350
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	PRICKLE2 SYN2 UBR3 POMGNT2 TRIM29 SPTAN1 SACM1L	1.19e-04	1139	35	7	36417873
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	ACTN2 SPRED2 SIPA1 TRIM29 SPTAN1	1.41e-04	503	35	5	36217030
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	UBR2 SNX33 POMGNT2 TRIM29 ZNF598 SACM1L	1.94e-04	857	35	6	25609649
Pubmed	Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6.	UBR2 UBR3	2.24e-04	22	35	2	24981174
Pubmed	Large-scale identification of human genes implicated in epidermal barrier function.	EGF TRIM29	4.20e-04	30	35	2	17562024
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	UBR3 ACTN2 TRIM29 SPTAN1 SACM1L	4.49e-04	647	35	5	26618866
Pubmed	Absence of canonical Smad signaling in ureteral and bladder mesenchyme causes ureteropelvic junction obstruction.	ROBO1 ACTN2	4.49e-04	31	35	2	22282597
Pubmed	The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway.	ROBO1 ULK1	4.49e-04	31	35	2	29099309
Pubmed	KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation.	UBR2 UBR3	5.09e-04	33	35	2	25582440
Pubmed	Chromosomal location of the octamer transcription factors, Otf-1, Otf-2, and Otf-3, defines multiple Otf-3-related sequences dispersed in the mouse genome.	EGF SPTAN1	7.12e-04	39	35	2	1676977
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR2 UBR3	4.16e-05	7	26	2	785
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF845 ZNF527 ZNF598 ZNF433	1.84e-02	718	26	4	28
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRICKLE2 SYN2 EGF PIK3C2G	7.40e-06	160	35	4	2d391ba6f7adb55dfa89feecc10cc9ce97e5fe74
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRICKLE2 SYN2 EGF PIK3C2G	7.40e-06	160	35	4	8bcdbcfdf1e0ace6053e8de82762f6e2f86bba7a
Disease	Ovarian Mucinous Adenocarcinoma	ULK1 CDKL2	5.87e-04	31	34	2	C1335167
Disease	spleen volume	SYN2 EGF	1.13e-03	43	34	2	EFO_0600047
Disease	lip morphology measurement	ADAP1 POMGNT2 SACM1L	1.34e-03	189	34	3	EFO_0007845
Disease	basophil percentage of leukocytes	ATP8B4 SPRED2 STK25	2.73e-03	243	34	3	EFO_0007992
Disease	Autistic Disorder	ROBO1 CHD8 EGF	3.34e-03	261	34	3	C0004352
Disease	Cleft Palate	TSR2 EGF	3.94e-03	81	34	2	C0008925

Protein segments in the cluster

Peptide	Gene	Start	Entry
IFFDDHMFHIEGAQR	NT5C1B	581	Q96P26
AQMRHFFHEDEEPFN	CHD8	706	Q9HCK8
SFNHFDRRKNGLMDH	ACTN2	761	P35609
EFMASHGNDAARARF	ADAP1	71	O75689
QADREFQFFDHHLME	ATP8B4	441	Q8TF62
IRHHGDVMDLQFFDQ	NUP43	71	Q8NFH3
NSDHRRFRDLNHYME	PIK3C2G	1271	O75747
MEGQDEVSAREQHFH	LMBR1	1	Q8WVP7
REMPSDNHQEDEFRH	LRRC36	241	Q1X8D7
ANRFNPDNLMHVFHD	POMGNT2	156	Q8NAT1
RDLQSHGRMHQSFDF	PRICKLE2	631	Q7Z3G6
LLHHDFFQMDGFAER	CDKL2	281	Q92772
LFANSQDIRHMHFDG	EGF	486	P01133
FNMEKRRGHHDDSDE	CEP350	1636	Q5VT06
FHEQRDCDEHNVMAR	CST9L	31	Q9H4G1
VANHMDGFQRHFDSQ	SACM1L	281	Q9NTJ5
NIIFRMEDGHHQVDF	FREM3	516	P0C091
RQHAFGMAENEDFRH	SYN2	186	Q92777
FIERNHMENGGDHRY	TRIM29	436	Q14134
RVVGFALQAEMNHFH	SNX33	521	Q8WV41
QAAGHARQFHAMATR	SIPA1	516	Q96FS4
NNGRHHRMDEFSRGN	SAP18	36	O00422
MAHLRGFANQHSRVD	STK25	1	O00506
RHERHHIGDFCFQEM	ZNF845	76	Q96IR2
MFHHFQRGDGAALRE	TSR2	96	Q969E8
NESHRLHQFFRDMDD	SPTAN1	1761	Q13813
YCRDMFNHEENRRGH	SPRED2	311	Q7Z698
RQMQDAAGRRHFHAS	ROBO1	1421	Q9Y6N7
FGDLEQHMRRQHELF	ZNF598	131	Q86UK7
QGDHTGHDFNMFRSQ	UBR3	151	Q6ZT12
HNIRDACRDHMEGYH	TPBG	386	Q13641
MDHLRHRDAQGRFQF	UBR2	446	Q8IWV8
NFSFFQIHERMHREE	ZNF433	461	Q8N7K0
RNHKDRMDFDEFFHH	ULK1	261	O75385
FELHQGNAERHFMQV	ZNF527	136	Q8NB42