Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionMHC protein binding

HLA-B HLA-C MFSD6 KIR2DL1 KIR2DS4 KIR3DL1

3.08e-0758946GO:0042287
GeneOntologyMolecularFunctionMHC class Ib protein binding

KIR2DL1 KIR2DS4 KIR3DL1

5.41e-0516943GO:0023029
GeneOntologyMolecularFunctionMHC class Ib receptor activity

KIR2DL1 KIR2DS4 KIR3DL1

9.27e-0519943GO:0032394
GeneOntologyMolecularFunctiontranscription corepressor activity

CASP8AP2 CBX4 MED1 RUNX1T1 ARID5A NCOR2 SETD5

1.05e-04229947GO:0003714
GeneOntologyMolecularFunctionMHC class I protein binding

HLA-B HLA-C MFSD6

4.54e-0432943GO:0042288
GeneOntologyMolecularFunctionTAP complex binding

HLA-B HLA-C

7.73e-049942GO:0062061
GeneOntologyMolecularFunctionCD8 receptor binding

HLA-B HLA-C

7.73e-049942GO:0042610
GeneOntologyMolecularFunctionTAP1 binding

HLA-B HLA-C

9.63e-0410942GO:0046978
GeneOntologyMolecularFunctionTAP2 binding

HLA-B HLA-C

9.63e-0410942GO:0046979
GeneOntologyMolecularFunctionTAP binding

HLA-B HLA-C

9.63e-0410942GO:0046977
GeneOntologyMolecularFunctiontranscription coregulator activity

CASP8AP2 BCLAF1 CAMTA2 CBX4 MED1 RUNX1T1 ARID5A NCOR2 SETD5

1.32e-03562949GO:0003712
GeneOntologyMolecularFunctionbeta-2-microglobulin binding

HLA-B HLA-C

1.40e-0312942GO:0030881
GeneOntologyMolecularFunctionmolecular adaptor activity

CASP8AP2 ANK2 BCLAF1 CAMTA2 CBX4 MED1 RUNX1T1 SPATA2 ARID5A NCOR2 SETD5 KIR2DL1 KIR2DS4 KIR3DL1 RHNO1

1.61e-0313569415GO:0060090
DomainLRRC37AB_C

LRRC37A3 LRRC37A2 LRRC37A

5.08e-074953PF14914
DomainLRRC37_N

LRRC37A3 LRRC37A2 LRRC37A

5.08e-074953IPR032754
DomainLRRC37AB_C

LRRC37A3 LRRC37A2 LRRC37A

5.08e-074953IPR029423
DomainLRRC37

LRRC37A3 LRRC37A2 LRRC37A

5.08e-074953PF15779
DomainLRRC37A/B-like

LRRC37A3 LRRC37A2 LRRC37A

5.08e-074953IPR015753
Domainig

KIR2DS2 PTPRD KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

5.24e-05190957PF00047
DomainImmunoglobulin

KIR2DS2 PTPRD KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

5.24e-05190957IPR013151
DomainPDZ

MAGI1 ARHGEF11 RGS12 MAST4 LNX1 PDZD2

8.33e-05141956PF00595
DomainPDZ

MAGI1 ARHGEF11 RGS12 MAST4 LNX1 PDZD2

1.09e-04148956SM00228
Domain-

MAGI1 ARHGEF11 RGS12 MAST4 LNX1 PDZD2

1.17e-041509562.30.42.10
DomainPDZ

MAGI1 ARHGEF11 RGS12 MAST4 LNX1 PDZD2

1.22e-04151956PS50106
DomainPDZ

MAGI1 ARHGEF11 RGS12 MAST4 LNX1 PDZD2

1.26e-04152956IPR001478
DomainIG_LIKE

HLA-B HLA-C KIR2DS2 IGSF11 PTPRD KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.97e-044919510PS50835
DomainIg-like_dom

HLA-B HLA-C KIR2DS2 IGSF11 PTPRD KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

2.39e-045039510IPR007110
DomainMHC_I_a_C

HLA-B HLA-C

3.79e-046952IPR010579
DomainMHC_I_C

HLA-B HLA-C

3.79e-046952PF06623
DomainRGS

ARHGEF11 RGS7 RGS12

7.42e-0435953SM00315
DomainRGS

ARHGEF11 RGS7 RGS12

8.06e-0436953PS50132
DomainIg-like_fold

HLA-B HLA-C KIR2DS2 CAMTA2 IGSF11 PTPRD KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

9.08e-047069511IPR013783
DomainRGS

ARHGEF11 RGS7 RGS12

1.02e-0339953IPR016137
DomainIG

KIR2DS2 IGSF11 PTPRD KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.37e-03421958SM00409
DomainIg_sub

KIR2DS2 IGSF11 PTPRD KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.37e-03421958IPR003599
Domain-

HLA-B HLA-C KIR2DS2 IGSF11 PTPRD KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.99e-0366395102.60.40.10
DomainChromodomain_CS

CHD2 CBX4

3.71e-0318952IPR023779
DomainSH3

TNK1 CACNB2 SH3D21 ARHGEF7 TNK2

4.93e-03216955SM00326
DomainSH3

TNK1 CACNB2 SH3D21 ARHGEF7 TNK2

4.93e-03216955PS50002
DomainMHC_I

HLA-B HLA-C

5.05e-0321952PF00129
DomainMHC_I_a_a1/a2

HLA-B HLA-C

5.05e-0321952IPR001039
DomainSH3_domain

TNK1 CACNB2 SH3D21 ARHGEF7 TNK2

5.32e-03220955IPR001452
Domain-

RGS7 RGS12

5.53e-03229521.10.196.10
DomainRGS_subdom1

RGS7 RGS12

5.53e-0322952IPR024066
DomainPH_dom-like

ARHGEF11 CIT RGS12 ARHGEF7 OSBPL8 PLCB1 TNS4

6.04e-03426957IPR011993
DomainChromo_domain

CHD2 CBX4

6.57e-0324952IPR023780
Domain-

HLA-B HLA-C

6.57e-03249523.30.500.10
DomainMHC_I-like_Ag-recog

HLA-B HLA-C

6.57e-0324952IPR011161
DomainGuanylate_kin

MAGI1 CACNB2

7.68e-0326952PF00625
DomainGK/Ca_channel_bsu

MAGI1 CACNB2

7.68e-0326952IPR008145
DomainGuanylate_kin-like_dom

MAGI1 CACNB2

7.68e-0326952IPR008144
DomainChromo

CHD2 CBX4

7.68e-0326952PF00385
DomainGuKc

MAGI1 CACNB2

7.68e-0326952SM00072
DomainCHROMO_1

CHD2 CBX4

8.88e-0328952PS00598
DomainCHROMO_2

CHD2 CBX4

8.88e-0328952PS50013
PathwayKEGG_ANTIGEN_PROCESSING_AND_PRESENTATION

HLA-B HLA-C KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

2.29e-0788697M16004
PathwayKEGG_GRAFT_VERSUS_HOST_DISEASE

HLA-B HLA-C KIR2DL1 KIR2DL2 KIR3DL1

1.59e-0641695M13519
PathwayKEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY

HLA-B HLA-C KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

4.59e-06137697M5669
PathwayREACTOME_DAP12_INTERACTIONS

HLA-B HLA-C KIR2DL1 KIR2DS4 KIR3DL1

6.37e-0654695MM14871
PathwayREACTOME_DAP12_INTERACTIONS

HLA-B HLA-C KIR2DS2 KIR2DS4

7.35e-0546694M27151
PathwayKEGG_MEDICUS_PATHOGEN_KSHV_MIR1_2_TO_ANTIGEN_PROCESSING_AND_PRESENTATION_BY_MHC_CLASS_I_MOLECULES

HLA-B HLA-C

3.50e-046692M47468
PathwayKEGG_MEDICUS_PATHOGEN_HTLV_1_P12_TO_ANTIGEN_PROCESSING_AND_PRESENTATION_BY_MHC_CLASS_I_MOLECULES

HLA-B HLA-C

4.88e-047692M47582
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E5_TO_ANTIGEN_PROCESSING_AND_PRESENTATION_BY_MHC_CLASS_I_MOLECULES

HLA-B HLA-C

4.88e-047692M47530
PathwayREACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL

HLA-B HLA-C KIR2DL1 KIR2DS4 KIR3DL1

5.14e-04135695MM14781
Pubmed

Association of killer cell immunoglobulin-like receptors with primary Sjogren's syndrome.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

2.20e-1812103819181658
Pubmed

KIR and HLA genotypes are associated with disease progression and survival following autologous hematopoietic stem cell transplantation for high-risk neuroblastoma.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

5.70e-1813103819934297
Pubmed

Killer cell immunoglobulin-like receptors in HLA-B27-associated acute anterior uveitis, with and without axial spondyloarthropathy.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

2.84e-1715103819850842
Pubmed

Killer immunoglobulin-like receptors (KIR2DL2 and/or KIR2DS2) in presence of their ligand (HLA-C1 group) protect against chronic myeloid leukaemia.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

2.84e-1715103819493232
Pubmed

No association of KIR genes with Behcet's disease.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

5.66e-1716103817868255
Pubmed

The role of killer immunoglobulin-like receptor haplotypes on the outcome of unrelated donor haematopoietic SCT for thalassaemia.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.07e-1617103820173792
Pubmed

Role of killer cell immunoglobulin-like receptor gene content and human leukocyte antigen-C group in susceptibility to human T-lymphotropic virus 1-associated myelopathy/tropical spastic paraparesis in Peru.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.07e-1617103820483367
Pubmed

[Effects of killer immunoglobulin-like receptor and human leukocyte antigen class I ligand on the prognosis of related donor hematopoietic stem cell transplantation].

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.07e-1617103819968064
Pubmed

KIR genes and KIR ligands affect occurrence of acute GVHD after unrelated, 12/12 HLA matched, hematopoietic stem cell transplantation.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.07e-1617103819169284
Pubmed

Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.91e-1618103819630074
Pubmed

Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.91e-1618103820519398
Pubmed

Signatures of natural selection and coevolution between killer cell immunoglobulin-like receptors (KIR) and HLA class I genes.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.91e-1618103820200544
Pubmed

Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infection.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.91e-1618103819846535
Pubmed

Association of killer cell immunoglobulin-like receptors and human leukocyte antigen-C genotypes in South Brazilian with type 1 diabetes.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.91e-1618103820580654
Pubmed

Distribution of killer cell immunoglobulin-like receptor genes in the mestizo population from Venezuela.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.91e-1618103820210918
Pubmed

KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

3.30e-1619103818571006
Pubmed

Association between killer-cell immunoglobulin-like receptor genotypes and leprosy in Brazil.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

3.30e-1619103818778326
Pubmed

Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with solid tumors.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

3.30e-1619103820600442
Pubmed

Killer cell immunoglobulin-like receptor gene diversity in a Southern Brazilian population from the state of ParanĂ¡.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

3.30e-1619103818848853
Pubmed

Compound KIR-HLA genotype analyses in the Iranian population by a novel PCR-SSP assay.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

5.48e-1620103820193031
Pubmed

HLA and KIR frequencies in Sicilian Centenarians.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

5.48e-1620103820426625
Pubmed

Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

8.84e-1621103819861144
Pubmed

Distribution of killer cell immunoglobulin-like receptors (KIR) and their HLA-C ligands in two Iranian populations.

HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.27e-1512103719936734
Pubmed

Distribution of KIR genes in the population of unrelated individuals homozygous for ancestral haplotype AH8.1 (HLA-A1B8DR3).

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.39e-1522103820492596
Pubmed

Different KIRs confer susceptibility and protection to adults with latent autoimmune diabetes in Latvian and Asian Indian populations.

HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

2.75e-1513103719120281
Pubmed

[Killer cell immunoglobin-like receptor and its ligand gene polymorphisms in Hunan Han patients with type 1 diabetes].

HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.02e-1415103720356536
Pubmed

Inhibitory KIR and specific HLA-C gene combinations confer susceptibility to or protection against chronic hepatitis B.

HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.02e-1415103720643584
Pubmed

Killer cell immunoglobulin-like receptor genotype and killer cell immunoglobulin-like receptor-human leukocyte antigen C ligand compatibility affect the severity of hepatitis C virus recurrence after liver transplantation.

HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.02e-1415103719326408
Pubmed

Polymorphisms of KIR gene and HLA-C alleles: possible association with susceptibility to HLA-B27-positive patients with ankylosing spondylitis.

HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.82e-1416103720652381
Pubmed

A study of the killer cell immunoglobulin-like receptor gene KIR2DS1 in a Caucasoid Brazilian population with psoriasis vulgaris.

HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.82e-1416103718643961
Pubmed

Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA.

HLA-B KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.82e-1416103720331834
Pubmed

HLA-DQA1*0505 sharing and killer immunoglobulin-like receptors in sub fertile couples: report from the 15th International Histocompatibility Workshop.

HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.82e-1416103720210919
Pubmed

Immunogenetic characteristics of patients with autoimmune gastritis.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.83e-1429103820082482
Pubmed

Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation.

HLA-B HLA-C KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

3.08e-1417103719032228
Pubmed

The beneficial impact of missing KIR ligands and absence of donor KIR2DS3 gene on outcome following unrelated hematopoietic SCT for myeloid leukemia in the Chinese population.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4

3.08e-1417103720173784
Pubmed

Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

4.85e-14910367749980
Pubmed

Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals.

HLA-C KIR2DS2 KIR2DL1 KIR2DS3 KIR2DS4 KIR3DL1

4.85e-149103618340360
Pubmed

Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians.

HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

5.03e-1418103719046302
Pubmed

Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis.

HLA-B HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

9.88e-1435103819683555
Pubmed

Natural killer cells and immune surveillance.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

2.66e-1311103618830515
Pubmed

[Genotype analysis of killer cell immunoglobulin-like receptors in Graves' disease patients].

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

2.66e-1311103619664392
Pubmed

Association of killer cell immunoglobulin-like receptor 2DL5 with systemic lupus erythematosus and accompanying infections.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

5.30e-1312103620371502
Pubmed

[Relationship between CMV reactivation and KIR haplotype/HLA-Cw genotype in patients after unrelated-donor hematopoietic stem cell transplantation.].

HLA-C KIR2DS2 KIR2DL1 KIR2DS3 KIR2DS4 KIR3DL1

5.30e-1312103620137308
Pubmed

[Study on the polymorphism of killer cell immunoglobulin like receptor (KIR) gene with systemic lupus erythematosus of North population in China].

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

9.82e-1313103618687225
Pubmed

KIR, HLA, and IL28B variant predict response to antiviral therapy in genotype 1 chronic hepatitis C patients in Japan.

HLA-B HLA-C KIR2DS2 KIR2DL2 KIR3DL1

1.24e-126103524349500
Pubmed

Frequencies of killer immunoglobulin-like receptor genotypes influence susceptibility to spontaneous abortion.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.71e-1214103619875891
Pubmed

Multiple sclerosis associates with LILRA3 deletion in Spanish patients.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.71e-1214103619421224
Pubmed

Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.71e-1214103615896204
Pubmed

[Genotype and haplotype analysis of killer cell immunoglobulin-like receptors in ankylosing spondylitis].

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.71e-1214103619489269
Pubmed

Killer cell immunoglobulin-like receptor gene diversity in a Caucasian population of southern Brazil.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

2.85e-1215103620082646
Pubmed

Disparate distribution of activating and inhibitory killer cell immunoglobulin-like receptor genes in patients with systemic lupus erythematosus.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

2.85e-1215103619926642
Pubmed

Natural killer-cell receptor polymorphisms and posttransplantation non-Hodgkin lymphoma.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

2.85e-1215103620207982
Pubmed

KIR genes polymorphism in Argentinean Caucasoid and Amerindian populations.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

2.85e-1215103617498266
Pubmed

Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS4 KIR3DL1

4.32e-127103514607943
Pubmed

Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada syndrome in Japanese individuals.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

4.55e-1216103619897003
Pubmed

Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Java, Kalimantan, Timor and Irian Jaya.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

4.55e-1216103619000141
Pubmed

Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Sumatra, Sulawesi and Moluccas Islands.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

4.55e-1216103620670355
Pubmed

Activating killer cell immunoglobulin-like receptor genes' association with recurrent miscarriage.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

4.55e-1216103619527230
Pubmed

Asian population frequencies and haplotype distribution of killer cell immunoglobulin-like receptor (KIR) genes among Chinese, Malay, and Indian in Singapore.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

4.55e-1216103618668235
Pubmed

Influence of activating and inhibitory killer immunoglobulin-like receptors on predisposition to recurrent miscarriages.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

4.55e-1216103619279038
Pubmed

Distribution of killer cell immunoglobulin-like receptor (KIR) genotypes in patients with familial Mediterranean fever.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

4.55e-1216103619309280
Pubmed

[Polymorphism of killer cell immunoglobulin-like receptors gene family in Zhejiang Han population].

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

4.55e-1216103616403292
Pubmed

[Analysis of natural killer cell immunoglobulin-like receptor genes in Chinese].

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

7.02e-1217103619218127
Pubmed

Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

7.02e-1217103620878400
Pubmed

Killer cell immunoglobulin-like receptor gene diversity in the Tibetan ethnic minority group of China.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

7.02e-1217103620650299
Pubmed

Killer cell immunoglobulin-like receptor gene polymorphisms in patients with leukemia: possible association with susceptibility to the disease.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

7.02e-1217103619450876
Pubmed

Distribution of killer-cell immunoglobulin-like receptor genes in Eastern mainland Chinese Han and Taiwanese Han populations.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

7.02e-1217103619761533
Pubmed

Genotypes of NK cell KIR receptors, their ligands, and Fcγ receptors in the response of neuroblastoma patients to Hu14.18-IL2 immunotherapy.

HLA-B HLA-C KIR2DL1 KIR2DL2 KIR3DL1

1.15e-118103520935224
Pubmed

NullHap--a versatile application to estimate haplotype frequencies from unphased genotypes in the presence of null alleles.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4

1.15e-118103518681957
Pubmed

Alternatively spliced forms of human killer inhibitory receptors.

KIR2DS2 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

2.58e-11910358662091
Pubmed

Assessment of killer cell immunoglobulinlike receptor expression and corresponding HLA class I phenotypes demonstrates heterogenous KIR expression independent of anticipated HLA class I ligands.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR3DL1

5.14e-1110103512559621
Pubmed

KIR and their HLA Class I ligands: Two more pieces towards completing the puzzle of chronic rejection and graft loss in kidney transplantation.

HLA-B HLA-C KIR2DL1 KIR3DL1

7.25e-114103428686681
Pubmed

Association of killer cell immunoglobulin-like receptor genotypes with microscopic polyangiitis.

HLA-B KIR2DL1 KIR2DS3 KIR3DL1

3.62e-105103416508981
Pubmed

Genetic associations of killer immunoglobulin like receptors and class I human leukocyte antigens on childhood acute lymphoblastic leukemia among north Indians.

HLA-B HLA-C KIR2DS2 KIR2DS3

3.62e-105103426472014
Pubmed

Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3.

HLA-B HLA-C KIR2DL1 KIR2DL2

3.62e-105103418322206
Pubmed

Killer cell immunoglobulin-like receptor genotypes in Japanese patients with type 1 diabetes.

HLA-B HLA-C KIR2DL1 KIR3DL1

3.62e-105103417990989
Pubmed

Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS4 KIR3DL1

4.05e-1014103518945962
Pubmed

KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C.

HLA-B HLA-C KIR2DL1 KIR2DS4

1.08e-096103419858347
Pubmed

A human MAP kinase interactome.

MAGI1 CASP8AP2 HIVEP1 HLA-B NUP214 ARHGEF11 MEF2D CEP350 ARHGEF7 PLCB1 COBL TNK2 CGNL1

2.26e-094861031320936779
Pubmed

Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors.

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS4

2.52e-097103411169255
Pubmed

HLA-F and MHC-I Open Conformers Bind Natural Killer Cell Ig-Like Receptor KIR3DS1.

HLA-B HLA-C KIR2DS4 KIR3DL1

5.03e-098103427649529
Pubmed

KIR haplotype content at the allele level in 77 Northern Irish families.

KIR2DS2 KIR2DL2 KIR2DS4 KIR3DL1

5.03e-098103417200871
Pubmed

A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia.

KIR2DL1 KIR2DL2 KIR2DS4 KIR3DL1

5.03e-098103415730517
Pubmed

Distribution of KIR genes in the Czech population.

HLA-C KIR2DL1 KIR2DS4 KIR3DL1

9.04e-099103418186800
Pubmed

Distinctive KIR and HLA diversity in a panel of north Indian Hindus.

HLA-B HLA-C KIR2DL1 KIR3DL1

1.50e-0810103411904677
Pubmed

HLA-F and MHC class I open conformers are ligands for NK cell Ig-like receptors.

HLA-B HLA-C KIR2DL2 KIR2DS4

1.50e-0810103424018270
Pubmed

Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus.

KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.50e-0810103421206914
Pubmed

Evaluation of the genetic diversity of KIR genes in patients with endometrial cancer.

KIR2DS2 KIR2DL2 KIR2DS4

2.52e-083103338387251
Pubmed

Killer cell immunoglobulin-like receptor (KIR) genes in systemic sclerosis.

HLA-C KIR2DS2 KIR2DL2

2.52e-083103320082621
Pubmed

Inhibitory killer cell immunoglobulin-like receptor KIR3DL1 in combination with HLA-B Bw4iso protect against ankylosing spondylitis.

HLA-B HLA-C KIR3DL1

2.52e-083103320574122
Pubmed

[Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia].

KIR2DS2 KIR2DL1 KIR2DS4 KIR3DL1

3.53e-0812103417490516
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

MAGI1 TNK1 HIVEP1 TEX2 CBX4 MEF2D RGS12 CEP350 KIAA1671 MAST4 OSBPL8 COBL CGNL1 CAMSAP2 USP6NL

3.85e-088611031536931259
Pubmed

B-lymphoma cells escape rituximab-triggered elimination by NK cells through increased HLA class I expression.

HLA-C KIR2DL1 KIR2DL2

1.01e-074103320056126
Pubmed

HLA-C and KIR genes in hepatitis C virus infection.

HLA-C KIR2DL1 KIR2DL2

1.01e-074103316571411
Pubmed

Killer Ig-like receptor (KIR) genotype and HLA ligand combinations in ulcerative colitis susceptibility.

HLA-C KIR2DS2 KIR2DL2

1.01e-074103316929347
Pubmed

Genetic interactions of KIR and G1M immunoglobulin allotypes differ in obese from non-obese individuals with type 2 diabetes.

KIR2DL1 KIR2DS4 KIR3DL1

1.01e-074103318632158
Pubmed

KIR3DL1+HLA-B Bw4Ile80 and KIR2DS1+HLA-C2 combinations are both associated with ankylosing spondylitis in the Iranian population.

HLA-B HLA-C KIR3DL1

1.01e-074103321797986
Pubmed

KIR/HLA ligand incompatibility in kidney transplantation.

HLA-C KIR2DS2 KIR2DL2

1.01e-074103318091530
Pubmed

[Analysis of HLA-Cw, KIR2D genetic variations in 2 Chinese populations].

HLA-C KIR2DL1 KIR2DL2

1.01e-074103318543232
Pubmed

Peptide-specific engagement of the activating NK cell receptor KIR2DS1.

HLA-B HLA-C KIR2DL1

1.01e-074103328546555
InteractionKIR2DL2 interactions

HLA-C KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR3DL1

1.89e-1113986int:KIR2DL2
InteractionKIR3DL1 interactions

HLA-B KIR2DS2 KIR2DL1 KIR2DL2 KIR3DL1

3.06e-0913985int:KIR3DL1
InteractionKIR2DL1 interactions

HLA-C PTPRD KIR2DL1 KIR2DL2 KIR2DS3 KIR3DL1

3.91e-0928986int:KIR2DL1
InteractionYWHAH interactions

MAGI1 TNK1 HIVEP1 TEX2 CBX4 MED1 ATXN1L MEF2D RGS12 PYHIN1 CEP350 KIAA1671 MAST4 ARHGEF7 OSBPL8 PACS2 COBL CGNL1 CAMSAP2 CLEC16A USP6NL

5.83e-0811029821int:YWHAH
InteractionKIR2DS2 interactions

HLA-C KIR2DS2 KIR2DL2 KIR2DS3 KIR3DL1

9.45e-0737985int:KIR2DS2
InteractionHLA-C interactions

DNAJB12 GPR50 HLA-B HLA-C TEX2 KIR2DS2 CIT KIR2DL1 KIR2DL2 KIR2DS4 CLEC16A

1.17e-063539811int:HLA-C
InteractionSFN interactions

MAGI1 TNK1 TEX2 CBX4 RGS12 CEP350 KIAA1671 MAST4 PACS2 COBL TNS4 CGNL1 CAMSAP2 USP6NL RPL18

1.21e-066929815int:SFN
InteractionSYNE3 interactions

DNAJB12 HLA-C TEX2 NUP214 SPATA2 CLCC1 JPH1 CEP350 KIAA1671 NCOR2 OSBPL8 CGNL1

1.65e-064449812int:SYNE3
InteractionYWHAG interactions

MAGI1 TNK1 HIVEP1 BCLAF1 CBX4 MEF2D RGS12 PYHIN1 CEP350 KIAA1671 MAST4 ARHGEF7 OSBPL8 PACS2 COBL TNK2 CGNL1 LNX1 CAMSAP2 USP6NL

1.96e-0612489820int:YWHAG
InteractionKIR2DS3 interactions

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3

2.40e-0620984int:KIR2DS3
InteractionGSK3A interactions

TEX2 BCLAF1 LRRC37A2 ARHGEF11 CEP350 KIAA1671 MAST4 COBL CAMSAP2 SLX4 RPL18

1.58e-054649811int:GSK3A
InteractionKIR2DS4 interactions

HLA-C KIR2DS4

2.34e-052982int:KIR2DS4
InteractionHNF1B interactions

HIVEP1 BCLAF1 ATXN1L MEF2D NCOR2 CABIN1 RPL18

3.98e-05190987int:HNF1B
InteractionCBFA2T2 interactions

RUNX1T1 ATXN1L NCOR2 TAL1

6.72e-0545984int:CBFA2T2
InteractionSDC2 interactions

GPR50 TEX2 CBX4 PYHIN1 GTF3C1 OSBPL8

7.08e-05143986int:SDC2
InteractionYWHAB interactions

MAGI1 TNK1 HIVEP1 CBX4 RGS7 RGS12 CEP350 KIAA1671 MAST4 ARHGEF7 PACS2 CGNL1 LNX1 CAMSAP2 USP6NL

1.10e-0410149815int:YWHAB
InteractionMIEN1 interactions

HIVEP1 ARID5A NLGN3

1.20e-0420983int:MIEN1
InteractionNLGN3 interactions

HIVEP1 NLGN3 PTPRD COBL TNK2

1.22e-0499985int:NLGN3
InteractionRHOC interactions

HLA-B HLA-C MFSD6 ABCC5 ARHGEF11 CIT CLCC1 JPH1 OSBPL8 LNX1 CLEC16A

1.26e-045849811int:RHOC
InteractionKIR3DP1 interactions

KIR2DS2 KIR2DL1

1.40e-044982int:KIR3DP1
InteractionKIR2DS1 interactions

HLA-C KIR2DS2

1.40e-044982int:KIR2DS1
InteractionDNAJC16 interactions

HLA-B HLA-C CLCC1 JPH1 OSBPL8 CLEC16A RPL18

1.43e-04233987int:DNAJC16
InteractionEYA4 interactions

CBX4 SPATA2 ATXN1L NCOR2 AMOTL1 AUTS2 SPTY2D1

1.85e-04243987int:EYA4
InteractionYWHAZ interactions

TNK1 HIVEP1 TEX2 CBX4 SPATA2 RGS12 KIAA1671 MAST4 ARHGEF7 AMOTL1 OSBPL8 PACS2 TNK2 CGNL1 LNX1 CAMSAP2 USP6NL

1.95e-0413199817int:YWHAZ
InteractionPAX8 interactions

HIVEP1 ATXN1L CIT MEF2D NCOR2

2.09e-04111985int:PAX8
InteractionASF1A interactions

CASP8AP2 HIVEP1 MEF2D NCOR2 GTF3C1 CABIN1 SPTY2D1

2.15e-04249987int:ASF1A
InteractionNUP43 interactions

CASP8AP2 HIVEP1 BCLAF1 CCDC168 NUP214 CIT KANSL3 NCOR2 SLX4 RPL18 PDZD2

2.27e-046259811int:NUP43
InteractionPRRT3 interactions

PTPRD PRRT3

2.32e-045982int:PRRT3
Cytoband19q13.4

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

2.68e-0879103619q13.4
Cytoband3p25.3

FANCD2OS SETD5 PRRT3

1.45e-044510333p25.3
Cytoband6q22-q23

BCLAF1 LAMA2

2.22e-041010326q22-q23
GeneFamilyCD molecules|Killer cell immunoglobulin like receptors

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

9.62e-1218546620
GeneFamilyPDZ domain containing

MAGI1 ARHGEF11 RGS12 MAST4 LNX1 PDZD2

5.92e-061525461220
GeneFamilyRegulators of G-protein signaling

RGS7 RGS12

1.77e-0321542720
GeneFamilyAtaxins|Trinucleotide repeat containing

MAGI1 NCOR2

2.51e-0325542775
GeneFamilyCalcium voltage-gated channel subunits|Membrane associated guanylate kinases

MAGI1 CACNB2

2.72e-0326542904
CoexpressionKAZMIN_PBMC_P_FALCIPARUM_RTSS_AS01_AGE_UNKNOWN_CORRELATED_WITH_PROTECTION_56DY_NEGATIVE

KIR2DS2 KIR2DL1 KIR2DL2 KIR2DS3 KIR3DL1

1.35e-06491025M40909
CoexpressionHE_LIM_SUN_FETAL_LUNG_C1_SMG_CELL

BORCS6 HLA-B MFSD6 FXYD5 CBX4 ARHGEF11 CBS ARID5A KIAA1671 CARD6 COBL LNX1 IQCE

9.92e-0677510213M45713
CoexpressionGSE20500_RETINOIC_ACID_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_DN

DNAJB12 CBX4 MEF2D GVINP1 ARHGEF7 CAMSAP2 USP6NL

1.27e-051981027M7708
CoexpressionGSE32533_WT_VS_MIR17_KO_ACT_CD4_TCELL_UP

RUNX1T1 ATXN1L CIT AMOTL1 AUTS2 ZFYVE26 IQCE

1.36e-052001027M8469
CoexpressionHADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_UP

CACNB2 BCLAF1 PTPRD TAL1 PDZD2

1.64e-05811025M17082
CoexpressionDAWSON_METHYLATED_IN_LYMPHOMA_TCL1

RUNX1T1 PTPRD AUTS2 CLEC16A

8.35e-05591024M1238
CoexpressionDAWSON_METHYLATED_IN_LYMPHOMA_TCL1

RUNX1T1 PTPRD AUTS2 CLEC16A

8.35e-05591024MM528
CoexpressionMASSARWEH_TAMOXIFEN_RESISTANCE_UP

MFSD6 ABCC5 RAB20 ATXN1L PRRT3 LNX1 MUC2 SPTY2D1 IQCE PDZD2

9.34e-0558310210M17454
CoexpressionZIRN_TRETINOIN_RESPONSE_WT1_UP

ZNF133 KANSL3 TAL1

9.57e-05231023M17312
CoexpressionHAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP

GLIPR1 NUP214 RAB20 KIR3DL1

1.08e-04631024M9775
CoexpressionTABULA_MURIS_SENIS_LUNG_PULMONARY_INTERSTITIAL_FIBROBLAST_AGEING

HLA-B HLA-C FXYD5

1.09e-04241023MM3773
CoexpressionGSE17974_0.5H_VS_72H_IL4_AND_ANTI_IL12_ACT_CD4_TCELL_UP

HIVEP1 FXYD5 CHD2 NUP214 SPATA2 USP6NL

1.20e-041961026M4244
CoexpressionGSE20152_SPHK1_KO_VS_HTNFA_OVEREXPRESS_ANKLE_DN

MAGI1 CASP8AP2 ABCC5 CIT CEP350 RPL18

1.24e-041971026M7683
CoexpressionGSE22025_TGFB1_VS_TGFB1_AND_PROGESTERONE_TREATED_CD4_TCELL_DN

NCOR2 OSBPL8 PLCB1 TNK2 CABIN1 CAMSAP2

1.31e-041991026M8388
CoexpressionGSE1460_INTRATHYMIC_T_PROGENITOR_VS_CD4_THYMOCYTE_DN

HLA-B HLA-C RGS12 GVINP1 OSBPL8 CAMSAP2

1.31e-041991026M3440
CoexpressionGSE45739_UNSTIM_VS_ACD3_ACD28_STIM_NRAS_KO_CD4_TCELL_DN

HLA-C KIR2DS2 GTF3C1 AUTS2 KIR2DL1 KIR2DL2

1.31e-041991026M9885
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI1 CACNB2 ANK2 RGS7 MAST4 PLCB1 CGNL1 LNX1

9.40e-09183101831ab55d5f3639f5964541d5eae23044dbda3356e
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI1 CACNB2 ANK2 RGS7 MAST4 PLCB1 CGNL1 LNX1

1.02e-081851018898a093757f86be3e18d2ef1f16a71f50ef81dc3
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI1 CACNB2 ANK2 RGS7 MAST4 PLCB1 CGNL1 LNX1

1.11e-081871018b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
ToppCell10x5'-blood-Lymphocytic_NK-NK_CD16|blood / Manually curated celltypes from each tissue

HLA-B HLA-C PYHIN1 GTF3C1 AUTS2 KIR2DL1 KIR3DL1

3.04e-071941017c34a32f1cfe3e597cb0f91ba5bdd3e114e9f3d2e
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

MAGI1 CHD2 CIT MAST4 PTPRD AUTS2 PDZD2

3.04e-07194101797534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell3'_v3-bone_marrow-Lymphocytic_NK-NK_CD16|bone_marrow / Manually curated celltypes from each tissue

HLA-B HLA-C PYHIN1 GTF3C1 AUTS2 KIR2DL1 KIR3DL1

3.04e-0719410177773501e076d470158dbc1d7f10c67152b326eb7
ToppCell10x5'-blood-Lymphocytic_NK|blood / Manually curated celltypes from each tissue

HLA-B HLA-C PYHIN1 GTF3C1 AUTS2 KIR2DL1 KIR3DL1

3.14e-071951017c1db871e8e8e8b8d6a5798bc43eaf54e102b75eb
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_NK-NK_CD16|lymph-node_spleen / Manually curated celltypes from each tissue

HLA-B HLA-C PYHIN1 GTF3C1 AUTS2 KIR2DL1 KIR3DL1

3.14e-071951017e756733cf48768bf40058d6cf9039e52f7563133
ToppCell10x5'-bone_marrow-Lymphocytic_NK-NK_CD16|bone_marrow / Manually curated celltypes from each tissue

HLA-B HLA-C PYHIN1 GTF3C1 AUTS2 KIR2DL1 KIR3DL1

3.25e-071961017a3b077e82b1550eb328c84b567b60179001f9a77
ToppCell10x5'-bone_marrow-Lymphocytic_NK|bone_marrow / Manually curated celltypes from each tissue

HLA-B HLA-C PYHIN1 GTF3C1 AUTS2 KIR2DL1 KIR3DL1

3.25e-0719610171868ad537b7f04cdad0a0c8282aadbc4f257a722
ToppCellsevere_COVID-19-NK|World / disease group, cell group and cell class (v2)

HLA-B HLA-C PYHIN1 GTF3C1 AUTS2 KIR2DL1 KIR3DL1

3.49e-07198101736b1370ef68c4bbe0268933a6ef5e6022d992bdf
ToppCellmild_COVID-19-NK|mild_COVID-19 / disease group, cell group and cell class (v2)

HLA-B HLA-C PYHIN1 GTF3C1 AUTS2 KIR2DL1 KIR3DL1

3.61e-0719910174854f25ee436e1cf577744373ffd87b1221d2b88
ToppCell356C-Fibroblasts-Fibroblast-D|356C / Donor, Lineage, Cell class and subclass (all cells)

LRRC37A3 LAMA2 CCDC168 RUNX1T1 ARID5A NLGN3

2.19e-0616610167286a37b2827f3747469ffd0d76cbe81116db7ee
ToppCell356C-Fibroblasts-Fibroblast-D-|356C / Donor, Lineage, Cell class and subclass (all cells)

LRRC37A3 LAMA2 CCDC168 RUNX1T1 ARID5A NLGN3

2.19e-0616610167c2eee0a4f45795a956acf936b85bdb35f1b1624
ToppCelldroplet-Marrow-BM-1m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNK1 PYHIN1 NLGN3 GVINP1 AUTS2 PACS2

2.34e-0616810162e88d9cb7c80a4656fab290db8b45a5a0599d769
ToppCelldroplet-Marrow-nan-3m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLCC1 PYHIN1 KANSL3 GTF3C1 GVINP1 ARHGEF7

2.42e-0616910165f5bec13208f4c3b6eacbba180c8a6402743b76e
ToppCellNS-critical-LOC-Lymphoid-NK|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PYHIN1 PLCB1 AUTS2 KIR2DL1 KIR2DL2 KIR3DL1

2.59e-061711016adda76991d9b150bb8ccf3989b7cbbf41843cf0b
ToppCellASK428-Immune-NK_cell|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

HLA-B HLA-C PYHIN1 KIR2DL1 KIR2DL2 KIR3DL1

3.49e-061801016857d09446e3e6737e83d0f10bfda2ba282d5ba75
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ANK2 ABCC5 MAST4 PLCB1 CGNL1 LNX1

3.49e-0618010169e09b3dfe344b5d50520711513d389865d73a861
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANK2 RGS7 MAST4 PLCB1 CGNL1 LNX1

3.49e-061801016eee71184ebed2694d3e60f579a44b3cf7dd2cd35
ToppCellASK440-Immune-NK_cell|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

HLA-B HLA-C PYHIN1 KIR2DL1 KIR2DL2 KIR3DL1

3.49e-061801016340e750356d23fe9af0e8f298f8a273ff426052f
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANK2 RGS7 MAST4 PLCB1 CGNL1 LNX1

3.49e-061801016a17dbe03597b81e7a1fe2bf2d23e59e55c615a2a
ToppCellLV-15._Ventricular_Cardiomyocyte_III|LV / Chamber and Cluster_Paper

MAGI1 CACNB2 ANK2 LAMA2 MAST4 PDZD2

3.96e-061841016ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCellSmart-seq2-bone_marrow_(Smart-seq2)-lymphocytic-innate_lymphocytic-mature_NK_T_cell|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HLA-B HLA-C PYHIN1 KIR2DL1 KIR2DS4 KIR3DL1

4.21e-0618610161590fe72badffc79f1d390deb3207116ac2281bb
ToppCellSmart-seq2-bone_marrow_(Smart-seq2)-lymphocytic-innate_lymphocytic|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HLA-B HLA-C PYHIN1 KIR2DL1 KIR2DS4 KIR3DL1

4.21e-061861016e84a0ba599935ca5e7af48e0fb0500e7ed195d55
ToppCellCOVID-19-Epithelial-Ionocytes|COVID-19 / Condition, Lineage and Cell class

MAGI1 ANK2 RGS7 CGNL1 LNX1 PDZD2

4.48e-061881016a581cb9528d0febbf3addbb4f6bc140f91a584e6
ToppCellRV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

MAGI1 CACNB2 ANK2 LAMA2 MAST4 PDZD2

4.62e-0618910165e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell(1)_T_CD8_gd|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

HLA-B HLA-C PYHIN1 KIAA1671 KIR2DL1 KIR3DL1

4.62e-06189101662eda4bcfd21d5025ac676d524994ede22721c1d
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

MAGI1 CACNB2 ANK2 LAMA2 JPH1 MAST4

4.76e-06190101693c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCellLV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

MAGI1 CACNB2 ANK2 LAMA2 MAST4 PDZD2

4.76e-061901016de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCellControl-Lymphoid-NK|Lymphoid / Disease state, Lineage and Cell class

PYHIN1 GTF3C1 PLCB1 AUTS2 KIR2DS4 KIR3DL1

4.76e-0619010161584c68b58c7f406d9b0e8451beea3e6f8980c56
ToppCellRV-06._Ventricular_Cardiomyocyte_II|RV / Chamber and Cluster_Paper

MAGI1 CACNB2 ANK2 LAMA2 MAST4 PDZD2

4.76e-061901016fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNB2 RGS7 MAST4 PLCB1 CGNL1 LNX1

4.76e-061901016cc17ab84a9328124f146951c06be3eff9650d9fd
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KIAA1671 MAST4 PTPRD COBL CGNL1 PDZD2

4.91e-0619110163c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCellLV-06._Ventricular_Cardiomyocyte_II|LV / Chamber and Cluster_Paper

MAGI1 CACNB2 ANK2 LAMA2 MAST4 PDZD2

4.91e-06191101625f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KIAA1671 MAST4 PTPRD COBL CGNL1 PDZD2

4.91e-0619110161c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2|Children_(3_yrs) / Lineage, Cell type, age group and donor

MAGI1 MAST4 PTPRD AUTS2 CGNL1 PDZD2

4.91e-061911016a0332a4ef629510fb313ec119195c44a3f704a80
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4/8-lo-Tgd_CRTAM|lymph-node_spleen / Manually curated celltypes from each tissue

HLA-B HLA-C PYHIN1 AUTS2 KIR2DL1 KIR3DL1

4.91e-061911016f802a4686ecf00e8302047bfe23356f24b266cf8
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MAGI1 JPH1 MAST4 COBL MYRF PDZD2

4.91e-061911016ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCellChildren_(3_yrs)-Epithelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

MAGI1 MAST4 AUTS2 COBL CGNL1 PDZD2

4.91e-061911016e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4/8-lo|lymph-node_spleen / Manually curated celltypes from each tissue

HLA-B HLA-C PYHIN1 AUTS2 KIR2DL1 KIR3DL1

5.06e-0619210164d72b9264ed62e0c08cde4078061b348253f6989
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

MAGI1 MAST4 AUTS2 COBL CGNL1 PDZD2

5.06e-061921016efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell3'_v3-bone_marrow-Lymphocytic_NK|bone_marrow / Manually curated celltypes from each tissue

HLA-B PYHIN1 GTF3C1 AUTS2 KIR2DL1 KIR3DL1

5.21e-061931016e790ab76c12f74a13936c231076f1e397283efb3
ToppCellICU-SEP-Lymphocyte-T_NK-NK|ICU-SEP / Disease, Lineage and Cell Type

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

5.21e-061931016f110f86db305e41639087f5b1a2dff103c07adf0
ToppCellRV-09._Endothelium_I|World / Chamber and Cluster_Paper

HLA-B HLA-C RUNX1T1 KIAA1671 PLCB1 LNX1

5.21e-061931016e3fa47e2c7cd8a5b69186711c57751f2296de8ae
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-NK_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GLIPR1 HLA-B HLA-C PYHIN1 KIR2DL1 KIR3DL1

5.36e-0619410163fe32e38c95135d152acb1624fec1623339e144a
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

5.36e-061941016fa72c2f3e6b8bfc2ef126deb219ec6a44809385b
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD8-Tem/emra_CD8|lymph-node_spleen / Manually curated celltypes from each tissue

HLA-B HLA-C PYHIN1 GTF3C1 AUTS2 KIR3DL1

5.36e-061941016ecdfc27d06e363fb23f0309f26ef6404a89f14ec
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

5.36e-061941016bc7c4efe2a82057fb95582da983e36f413990902
ToppCelllymphoid-NK_cell|World / Lineage, cell class and subclass

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

5.36e-0619410164bf5a140be8691e4ec99d7ee15588fd48acd6fb5
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

5.36e-061941016b43788e458a80ab93f485f4577370aec448ad95e
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-innate_lymphocytic-mature_NK_T_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HLA-B PYHIN1 GTF3C1 KIR2DL1 KIR2DS4 KIR3DL1

5.36e-061941016ae5357e2a276473cde1fc8c43acaf9f69da35fd7
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-innate_lymphocytic|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HLA-B PYHIN1 GTF3C1 KIR2DL1 KIR2DS4 KIR3DL1

5.36e-0619410163a0b8b5d0354c43da57bb951cd8ba878363c3de5
ToppCellIIF-Lymphocyte-T_NK-NK|IIF / Disease, Lineage and Cell Type

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

5.52e-061951016464ce05cb52f78aee22d3baa6641b37bd53aae16
ToppCell3'_v3-blood-Lymphocytic_NK-NK_CD16|blood / Manually curated celltypes from each tissue

HLA-B HLA-C PYHIN1 GTF3C1 AUTS2 KIR2DL1

5.52e-061951016789149fb52d9d16393e1649358515add60d37f2d
ToppCellwk_20-22-Hematologic_Lymphocytic-NK|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

HLA-B HLA-C ARID5A PYHIN1 KIR2DL1 KIR3DL1

5.52e-061951016a868aadca4a81cfeb773a18b0daad1ea5ece8fa8
ToppCellCOVID-19-Heart-CM_2|Heart / Disease (COVID-19 only), tissue and cell type

MAGI1 CACNB2 ANK2 LAMA2 MAST4 COBL

5.52e-06195101675fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell3'_v3-blood-Lymphocytic_NK|blood / Manually curated celltypes from each tissue

HLA-B HLA-C PYHIN1 GTF3C1 AUTS2 KIR2DL1

5.52e-061951016731a454e45c7b610e0140312bcabaea711dcc766
ToppCellLV-09._Endothelium_I|World / Chamber and Cluster_Paper

HLA-B HLA-C RUNX1T1 KIAA1671 PLCB1 LNX1

5.52e-06195101619e0a6c3eae1615aaa39767300acd937dfcb2a7f
ToppCellT/NK_cells-CD56dim_NK_cell|World / Lineage and Cell class

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

5.52e-0619510166124e87cb9061bf8918377fb4a79084079ddfc16
ToppCellCOVID-19_Severe-Lymphoid_T/NK-gd_T|COVID-19_Severe / Disease group, lineage and cell class

HLA-B LAMA2 PYHIN1 GFY GTF3C1 KIR2DL2

5.52e-0619510169990440bda7fac5d00ef80444fab07459be625e1
ToppCell(0)_NK_cells|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

5.69e-0619610169b080859130cf156bfa833dc71fd39734cb9a32d
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

HLA-B LAMA2 PYHIN1 GFY GTF3C1 KIR2DL2

5.69e-061961016418e8e0a51c5cb60e3b903e7d2d800dc8b9f3d5c
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HLA-B LAMA2 PYHIN1 GFY GTF3C1 KIR2DL2

5.69e-061961016581fc8c8d42005aacd7b401a2c9d1fc331fb4af7
ToppCell(0)_NK|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

5.69e-061961016e2578a562d9903a33a7c60db229005680af8141c
ToppCell10x5'-Liver-Lymphocytic_NK-NK_CD16|Liver / Manually curated celltypes from each tissue

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

5.69e-061961016e6d4853ccefbcd45a019cee595811f0474dcc036
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

HLA-B LAMA2 PYHIN1 GFY GTF3C1 KIR2DL2

5.69e-0619610166beaf0c2799424c59819b286fbb5c1a83d85e4d1
ToppCell10x5'-lymph-node_spleen-Lymphocytic_NK-NK_CD16|lymph-node_spleen / Manually curated celltypes from each tissue

HLA-C PYHIN1 GTF3C1 AUTS2 KIR2DL1 KIR3DL1

5.69e-061961016f7e5a7fad4547e8ab9ab8b140239281832fb4260
ToppCelltumor_Lung-T/NK_cells-NK|tumor_Lung / Location, Cell class and cell subclass

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

5.69e-061961016006e630f3d8033f45c6b7e9154d77000c7b0cb70
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HLA-B LAMA2 PYHIN1 GFY GTF3C1 KIR2DL2

5.69e-061961016c35f2349dfe35baa845f790b9f31673dceac54c0
ToppCell10x5'-blood-Lymphocytic_T_CD8-Tem/emra_CD8|blood / Manually curated celltypes from each tissue

HLA-B HLA-C PYHIN1 GTF3C1 AUTS2 KIR3DL1

5.86e-06197101613e6611cde9364f0c1bf681b0b26c4d2725e5f4a
ToppCellmild-Lymphocytic-NK_cells|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

HLA-B HLA-C PYHIN1 KIR2DL1 KIR2DS4 KIR3DL1

6.03e-0619810161d20fc9948965de52a98f758035edfdd12cafc5f
ToppCell(0)_NK_FCGR3Apos|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

6.03e-06198101613f10f9233fc1523f0da2d9d59f3ced9c51a603a
ToppCell390C-Lymphocytic-NK_cells-NK_cell_B|390C / Donor, Lineage, Cell class and subclass (all cells)

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

6.03e-0619810160dc4a564dcab8ac42f238f98ee1f2090b0dcffe6
ToppCellMultiple_Sclerosis-Lymphocyte-T_NK-NK|Multiple_Sclerosis / Disease, Lineage and Cell Type

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

6.03e-061981016d413020012977eb8da0a5641dd16d0b0a60bec38
ToppCell390C-Lymphocytic-NK_cells|390C / Donor, Lineage, Cell class and subclass (all cells)

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

6.03e-061981016872ddb2738c5e0375830bb0e5b2c50383bf58738
ToppCell(2)_NK/T-(22)_CD8+_T_cell-(220)_CD8+_Cytotoxic_T_cell|(22)_CD8+_T_cell / immune cells in Peripheral Blood (logTPM normalization)

GLIPR1 HLA-B HLA-C PYHIN1 GTF3C1 PLCB1

6.03e-0619810161bb60688ff0e42471c8b646652fe95b9b28c41a3
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-NK|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

6.03e-061981016e39ef71f3a9e0591bc0300ae132036fe2f8d5716
ToppCellCOVID_vent-Lymphocytic-ILC|COVID_vent / Disease condition, Lineage, Cell class and subclass

HLA-B PYHIN1 AUTS2 KIR2DL1 KIR2DL2 KIR3DL1

6.21e-061991016e3ff7fa1b1de1aaf6b46cdf49afa95bad457728a
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HLA-B PYHIN1 GTF3C1 AUTS2 KIR2DL1 KIR3DL1

6.21e-061991016b03539908131308d7bf5036e78c4c840a6a79a17
ToppCell390C-Lymphocytic-NK_cells-NK_cell_A|390C / Donor, Lineage, Cell class and subclass (all cells)

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

6.21e-061991016f72db89fe7e511473fc849f8fadb8b6453ac8ae5
ToppCellPBMC-Control-Lymphocyte-T/NK-NK_cell-NK|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

6.21e-0619910164820f5bcd7bc34c2ebf6a3422cc8eb383a3b5a4e
ToppCellPBMC-Control-Lymphocyte-T/NK-NK_cell|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

6.21e-061991016eb05ccae5187e4701bbbe6d714a6d2808fbcf306
ToppCellPBMC-Control-Lymphocyte-T/NK-NK_cell|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

6.21e-06199101610c8729b779073c3bf808e85958d59147f0be5c5
ToppCellPBMC-Control-Lymphocyte-T/NK-NK_cell-NK-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

6.21e-061991016867fd292f3879982422e840e087bfdb3b21a8715
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

HLA-B PYHIN1 GTF3C1 AUTS2 KIR2DL1 KIR3DL1

6.21e-0619910167d071c88a003babf6dbdb84dde561fc03c92f375
ToppCellPBMC-Control-Lymphocyte-T/NK-NK_cell-NK-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

6.21e-0619910165e9fe852a70546c9d235414a2c26ca3e67ba6eb9
ToppCellControl-Lymphoid_T/NK-NK|Control / Disease group, lineage and cell class

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

6.21e-06199101694b2693a8378b9b2c58c6aebb2c6658d75b2e3de
ToppCellCOVID_vent-Lymphocytic-ILC-NK_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

HLA-B PYHIN1 AUTS2 KIR2DL1 KIR2DL2 KIR3DL1

6.21e-0619910165f914962e2572b0c6372465b81b7496fa663d93c
ToppCellsevere-gd_T|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

HLA-B HLA-C PYHIN1 GTF3C1 PLCB1 AUTS2

6.21e-061991016e5a17a9f8f3be05d6abe1116607d17633df3c7ef
ToppCellPBMC-Control-Lymphocyte-T/NK-NK_cell-NK|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

6.21e-061991016d2c9fb69e5ef75778a1652da293fcf8cfa7ecfcc
ToppCell5'-Adult-LymphNode-Hematopoietic-T_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HLA-B HLA-C FXYD5 ARID5A PYHIN1 RPL18

6.39e-062001016cf4d184ff07862fabb182dabf09b2c9aac491409
ToppCellMS-IIF-Lymphocyte-T/NK-NK|IIF / Disease, condition lineage and cell class

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

6.39e-0620010164f889cc5ab76a128fd781d927b0d8368f4f927b7
ToppCellSepsis-ICU-SEP-Lymphocyte-T/NK-NK|ICU-SEP / Disease, condition lineage and cell class

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

6.39e-0620010166813fa6d24950fac22e2b5bb26b64f79214163b6
ToppCellsevere-NK|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

HLA-B HLA-C PYHIN1 GTF3C1 AUTS2 KIR3DL1

6.39e-06200101664e8a6c36e0c654b7b2416c9f19b9058215222b1
ToppCellControl-Control-Lymphocyte-T/NK-NK|Control / Disease, condition lineage and cell class

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

6.39e-062001016c64c27dbf4df42ca2ad2bd94b50fab87b4050ef3
ToppCellMS-Multiple_Sclerosis-Lymphocyte-T/NK-NK|Multiple_Sclerosis / Disease, condition lineage and cell class

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1 KIR3DL1

6.39e-062001016d7a611d88107d84b5995b353e8cf95c6a7eb79de
ToppCellBronchial-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-NK|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HLA-B HLA-C PYHIN1 PLCB1 KIR2DL1 KIR3DL1

6.39e-0620010160f8e2fed93cc103b20a825d8d3e83787c5c015cc
ToppCellBLOOD--(0)_NK_cell-(0)_NK_cells_(CD56dim-like)|(0)_NK_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

HLA-B HLA-C PYHIN1 GTF3C1 KIR2DL1

2.00e-0514510156dd81d53d006fcc206a10969374a11c372f92133
ToppCell368C-Lymphocytic-NK_cells-NK_cell_A|368C / Donor, Lineage, Cell class and subclass (all cells)

PYHIN1 KIAA1671 KIR2DL1 KIR3DL1 TAL1

2.07e-0514610150e38e1fa40b1fcd1bb61f7af7cc2206846c192ae
ComputationalNeighborhood of IL2RB

KIR2DS2 KIR2DL1 KIR2DS4 KIR3DL1

1.37e-0446624GNF2_IL2RB
DrugD-Au

HLA-B HLA-C KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

5.11e-08771017CID000277822
DrugAa1

GLIPR1 KIR2DL1 KIR2DL2 KIR2DS3 KIR2DS4 KIR3DL1

1.88e-06831016CID009549188
DrugImidurea [39236-46-9]; Up 200; 10.4uM; MCF7; HT_HG-U133A

GLIPR1 CACNB2 FXYD5 NUP214 ARID5A NCOR2 PLCB1 AUTS2

2.57e-0619510183522_UP
DrugHydroxytacrine maleate (R,S) [118909-22-1]; Up 200; 12.2uM; PC3; HT_HG-U133A

BORCS6 DNAJB12 ANK2 NUP214 RGS12 NCOR2 PTPRD TNK2

2.87e-0619810186651_UP
DrugNifurtimox [23256-30-6]; Up 200; 14uM; MCF7; HT_HG-U133A

BORCS6 MFSD6 CBX4 SH3D21 ARID5A PLCB1 AUTS2 CABIN1

3.10e-0620010184953_UP
Drugvinblastine sulfate; Up 200; 0.1uM; PC3; HT_HG-U133A

GLIPR1 TNK1 CAMTA2 CLCC1 COBL TNK2 CABIN1

2.40e-0519210177556_UP
DrugGuaifenesin [93-14-1]; Up 200; 20.2uM; MCF7; HT_HG-U133A

BORCS6 CBX4 ARHGEF11 RGS12 PLCB1 IQCE RPL18

2.82e-0519710173431_UP
DrugSulfabenzamide [127-71-9]; Up 200; 14.4uM; MCF7; HT_HG-U133A

GLIPR1 CACNB2 LAMA2 NUP214 MEF2D MAST4 PLCB1

2.82e-0519710174979_UP
DrugPraziquantel [55268-74-1]; Up 200; 12.8uM; MCF7; HT_HG-U133A

GLIPR1 ANK2 RUNX1T1 ARID5A RGS12 PLCB1 TNK2

2.82e-0519710173189_UP
DrugAC1L1FCN

HLA-B HLA-C KIR3DL1

3.71e-05151013CID000003178
Diseasealcohol consumption measurement

MAGI1 HLA-B MFSD6 IGSF11 MED1 RUNX1T1 CIT RGS12 NCOR2 MAST4 PLCB1 AUTS2 COBL TAL1 CLEC16A IQCE

4.85e-06124210116EFO_0007878
Diseasekiller cell immunoglobulin-like receptor 2DS2 measurement

HLA-B HLA-C KIR2DL1

1.72e-05151013EFO_0801746
Diseaseamyloid-beta measurement

CACNB2 CHD2 NCOR2 PTPRD PLCB1 CGNL1 LNX1 PDZD2

3.10e-053551018EFO_0005194
Diseaseanxiety disorder, panic disorder

BORCS6 IQCE

3.47e-0531012EFO_0004262, EFO_0006788
DiseaseSchizophrenia

MAGI1 CACNB2 GPR50 HLA-B HLA-C LAMA2 ARHGEF11 CBS RGS12 PLCB1 AUTS2 CGNL1

4.97e-0588310112C0036341
Diseaseevent-related brain oscillation

ARID5A KANSL3

6.93e-0541012EFO_0004358
Diseaseallergic asthma (is_implicated_in)

HLA-B HLA-C

1.15e-0451012DOID:9415 (is_implicated_in)
Diseasecorpus callosum central volume measurement

LNX1 CLEC16A PDZD2

1.20e-04281013EFO_0010296
Diseasecysteine-rich with EGF-like domain protein 1 measurement

FANCD2OS SETD5 PRRT3

1.80e-04321013EFO_0021870
Diseasealopecia (is_implicated_in)

FOXN1 HLA-B

2.41e-0471012DOID:987 (is_implicated_in)
Diseasegraft-versus-host disease (implicated_via_orthology)

HLA-B HLA-C

2.41e-0471012DOID:0081267 (implicated_via_orthology)
DiseaseLEUKEMIA, ACUTE LYMPHOBLASTIC

NUP214 TAL1

3.20e-0481012613065
DiseaseAcute lymphoid leukemia

NUP214 TAL1

3.20e-0481012cv:C0023449
Diseasehuman immunodeficiency virus infectious disease (is_implicated_in)

HLA-B HLA-C KIR3DL1

3.25e-04391013DOID:526 (is_implicated_in)
Diseasecryptic phenotype measurement

CACNB2 SLC27A6 PLCB1

5.66e-04471013EFO_0021487
Diseasebeta-2 microglobulin measurement

HLA-B HLA-C

6.25e-04111012EFO_0005197
Diseaseinterstitial collagenase measurement

MMP20 MEF2D

6.25e-04111012EFO_0008193
Diseaseadult onset asthma

HLA-B MUC2 MYRF CLEC16A

7.36e-041181014EFO_1002011
Diseaselinoleoyl-arachidonoyl-glycerol (18:2/20:4) [2] measurement

MYRF PDZD2

7.49e-04121012EFO_0800500
Diseasesevere acute respiratory syndrome, COVID-19

MAGI1 PMS2 PTPRD ARHGEF7 AUTS2 KIR2DS4 PDZD2

8.84e-044471017EFO_0000694, MONDO_0100096
DiseaseNasal Cavity Polyp

HLA-B MYRF CLEC16A

8.97e-04551013EFO_1000391
DiseaseAlzheimer's disease (implicated_via_orthology)

HIVEP1 ANK2 PLCB1

9.96e-04571013DOID:10652 (implicated_via_orthology)
Diseasechildhood onset asthma

HLA-B LAMA2 MED1 PTPRD CLEC16A PDZD2

1.03e-033341016MONDO_0005405
Diseasewhite matter integrity

HLA-B HLA-C IGSF11 LNX1

1.06e-031301014EFO_0004641
Diseaseasthma

MAGI1 HIVEP1 HLA-B MED1 PYHIN1 LNX1 MUC2 MYRF CLEC16A

1.11e-037511019MONDO_0004979
Diseasesevere aplastic anemia

HLA-B SLC27A6

1.18e-03151012EFO_0006927
Diseasediffuse plaque measurement

CACNB2 ANK2 SLC27A6 NCOR2 MAST4 PTPRD PLCB1 LINC00114 LNX1

1.18e-037581019EFO_0010699
Diseasebody weight

ZNF133 CACNB2 HIVEP1 HLA-B RUNX1T1 SPATA31C1 MAST4 ARHGEF7 AUTS2 LNX1 TAL1 PDZD2

1.26e-03126110112EFO_0004338
Diseaseurate measurement, bone density

GLIPR1 CASP8AP2 ZNF133 MAST4 PTPRD PLCB1 CABIN1 PDZD2

1.31e-036191018EFO_0003923, EFO_0004531
Disease–

HLA-C KIR3DL1

1.35e-03161012609423
DiseaseSusceptibility to HIV infection

HLA-C KIR3DL1

1.35e-03161012cv:C1836230
Diseasebasophil count, eosinophil count

HLA-B ARID5A KANSL3 MEIOSIN CLEC16A

1.46e-032411015EFO_0004842, EFO_0005090
Diseaseparental longevity

ANK2 HLA-B HLA-C RGS12 CEP350 PTPRD IQCE

1.57e-034941017EFO_0007796
Diseasediastolic blood pressure, systolic blood pressure

CACNB2 ANK2 RGS12 CEP350 KIAA1671 LNX1 TAL1 CLEC16A

2.15e-036701018EFO_0006335, EFO_0006336
DiseaseCOVID-19 (is_implicated_in)

HLA-B HLA-C

2.33e-03211012DOID:0080600 (is_implicated_in)
DiseaseAntimigraine preparation use measurement

RUNX1T1 MEF2D

2.33e-03211012EFO_0009939
DiseasePrecursor B-cell lymphoblastic leukemia

HLA-C AUTS2

2.33e-03211012C1292769
Diseaseneutrophil count

MAGI1 HIVEP1 HLA-B HLA-C ABCC5 CIT CBS MEF2D GTF3C1 PLCB1 LNX1 MYRF

2.70e-03138210112EFO_0004833
DiseaseColorectal Carcinoma

CACNB2 PMS2 ANK2 ABCC5 RUNX1T1 PTPRD TNS4 CAMSAP2

2.86e-037021018C0009402
Diseaseunipolar depression, response to selective serotonin reuptake inhibitor

CBX4 PDZD2

3.05e-03241012EFO_0003761, EFO_0005658
DiseaseBrugada Syndrome (disorder)

CACNB2 ANK2

3.05e-03241012C1142166
Diseasediacylglycerol 34:1 measurement

PYHIN1 COBL

3.05e-03241012EFO_0010352
Diseasemalaria (is_implicated_in)

CBS KIR3DL1

3.05e-03241012DOID:12365 (is_implicated_in)
Diseaseneuroimaging measurement, brain volume measurement

CACNB2 ARHGEF11 JPH1 MAST4 LNX1

3.07e-032861015EFO_0004346, EFO_0006930
Diseaseresponse to anticonvulsant

CACNB2 ANK2 SLC27A6

3.14e-03851013GO_0036277
DiseaseAutism Spectrum Disorders

GPR50 CHD2 NLGN3

3.14e-03851013C1510586
Diseasediet measurement

HLA-B MFSD6 LAMA2 CHD2 IGSF11 TEX15 RUNX1T1 CIT RGS7 AUTS2

3.20e-03104910110EFO_0008111
Diseaseosteonecrosis

RGS7 PTPRD

3.31e-03251012EFO_0004259
Diseasemigraine disorder, diastolic blood pressure

MEF2D NCOR2

3.31e-03251012EFO_0006336, MONDO_0005277
Diseaseinflammatory bowel disease (implicated_via_orthology)

MUC2 PDZD2

3.31e-03251012DOID:0050589 (implicated_via_orthology)
DiseaseGlioma

PMS2 HLA-B HLA-C

3.35e-03871013C0017638

Protein segments in the cluster

PeptideGeneStartEntry
KPHSPRAVSSPATHS

LINC00114

46

Q6XXX2
THPTEVLKPVSQHPR

ARID5A

346

Q03989
KSSSTEPSPHIHPVD

GVINP1

956

Q7Z2Y8
SAPERKSPSHHRQPS

ARHGEF11

21

O15085
QILDTHPTKPAPRTH

CAMTA2

211

O94983
TTPAHSPVLKHPAAK

AMOTL1

901

Q8IY63
TIKPHSVPSHTLPSH

ARHGEF7

586

Q14155
TLPSHPVTPSSKHAD

ARHGEF7

596

Q14155
VTDPETHKSTKAAHP

FXYD5

86

Q96DB9
EGKPHSDKRSTSHLP

CASP8AP2

201

Q9UKL3
RKATDHPHPSTPATA

CIT

1296

O14578
PHHSQSTFRKTSPAP

TNK2

91

Q07912
PKPSANSVTSPHSKE

CACNB2

246

Q08289
ERPSHTVDISSHKPP

RAB20

211

Q9NX57
SKSHAAEPVRSHPPA

IQCE

356

Q6IPM2
PTEPSSKTGNPRHLH

KIR2DS2

231

P43631
DVPKKTTHRPHPAAS

ANK2

1796

Q01484
TTHRPHPAASPSLKS

ANK2

1801

Q01484
HPAASPSLKSERHAP

ANK2

1806

Q01484
ERHAPGSPSPKTERH

ANK2

1816

Q01484
SAKTERHPPVSPSSK

ANK2

1836

Q01484
RHPPVSPSSKTEKHS

ANK2

1841

Q01484
EKHSPVSPSTKTERH

ANK2

1876

Q01484
VSHLHPELPKPRVSS

FAM47C

771

Q5HY64
EIAKSPHSTVPEHHP

NCOR2

1591

Q9Y618
PTEPSSKTGNPRHLH

KIR2DL2

231

P43627
PTEPSSKTGNPRHLH

KIR2DS4

231

P43632
QTHHLASPSVSVKPP

LRRC37A3

401

O60309
GHSTPPKRTIVSPKH

LRRC37A3

626

O60309
TRLKPPHKLHPNFTS

GLIPR1

81

P48060
PPDLHKSSPHGEKRA

MAGI1

1276

Q96QZ7
LLEHSRKITPPSSPH

KIAA1671

1051

Q9BY89
QTHHLASPSVSVKPP

LRRC37A2

401

A6NM11
GHSTPPKRTIVSPKH

LRRC37A2

626

A6NM11
QTHHLASPSVSVKPP

LRRC37A

401

A6NMS7
GHSTPPKRTIVSPKH

LRRC37A

626

A6NMS7
EPLHSEHPSKRPCTI

RUNX1T1

256

Q06455
RKEEPSPLNLSHHTP

ATXN1L

356

P0C7T5
TPPRSPEASPKHSHS

JPH1

461

Q9HDC5
TSHPKPTTGHIKPAT

GPR50

496

Q13585
PTTGHIKPATSHAEP

GPR50

501

Q13585
PTEPSSKSGNPRHLH

KIR3DL1

326

P43629
AEPPKTHVTHHPLSD

HLA-C

206

P10321
PSKPHCPHSSSTTKR

MUC2

4656

Q02817
TDHRKPLISPQTSHK

PDZD2

1911

O15018
SVEKRHSSHPSPAPV

AUTS2

846

Q8WXX7
SNTPKPLHPTITCHE

LNX1

491

Q8TBB1
ATKTVKHGAPSPSHP

NUP214

1071

P35658
PTEPSSKTGNPRHLH

KIR2DS3

231

Q14952
PKASIVPSTHHSTSP

LAMA2

2251

P24043
GSIHSARSHKEPPSP

PACS2

336

Q86VP3
PKIRPTTHPTNASHQ

MFSD6

161

Q6ZSS7
ADPPKTHVTHHPISD

HLA-B

206

P01889
APKDPPESHSLHRSS

MEIOSIN

421

C9JSJ3
TKDLHQPSLSPASPH

OSBPL8

56

Q9BZF1
RHTTPTPSSKHPFKA

FANCD2OS

21

Q96PS1
SALKPIRTTSKHQHP

ABCC5

86

O15440
KVPPPDTTHSSHITR

NLGN3

646

Q9NZ94
SVSRKPRPPHTHSYT

IGSF11

391

Q5DX21
EHEPSLSSRHKNPAP

BORCS6

101

Q96GS4
TVKHSQPKPFHSVPS

CARD6

951

Q9BX69
SGDTPTTPKHPKDSR

CABIN1

1921

Q9Y6J0
DPSKTPHPESHVTHN

GFY

236

I3L273
PSQKSPHDSKSPLDH

CHD2

1791

O14647
PHDSKSPLDHRSPLE

CHD2

1796

O14647
PLTAHSPHAHPETKK

CGNL1

256

Q0VF96
SPHAHPETKKTRPDV

CGNL1

261

Q0VF96
PIHHIPSRRSPAKTI

BCLAF1

291

Q9NYF8
PPPTDTTHATHRKAG

DNAJB12

61

Q9NXW2
PPVTVKDDRTSSPHS

COBL

906

O75128
HPKPSEASTTLPESH

PYHIN1

421

Q6K0P9
SPSHKKRAADERHPP

CBX4

291

O00257
SESPHHHTAPAKSPK

CBS

61

P35520
SSAPVHAPRSHSPVK

CEP350

556

Q5VT06
SGSPPKSPRTTVHDK

DNAJC4

101

Q9NNZ3
KPVAAHSESSSHKPR

MAST4

2181

O15021
HKDRSPDPSTLASPH

FAM167A-AS1

16

Q96KT0
LKRHHPSSPLPGSKT

KANSL3

626

Q9P2N6
HHRFSPSQPKLPISS

CCDC168

4836

Q8NDH2
PTEPSSKTGNPRHLH

KIR2DL1

231

P43626
KTKSRVPPTSPSDHQ

PRRT3

191

Q5FWE3
PKSIHRDHIESPKTP

CAMSAP2

1266

Q08AD1
PKHERGSPSHSKSPA

MED1

1441

Q15648
TTHPHISIKSEPVSP

MEF2D

431

Q14814
KSSIPNNKEIPSHHP

PTPRD

1301

P23468
PHHKPSIPDLCDSSS

MMP20

286

O60882
DIRSHSPTHTPTPET

RGS7

236

P49802
PITHTRQVPSKPIDH

RHNO1

36

Q9BSD3
HSSRKPTTSKFPHLT

RHNO1

81

Q9BSD3
SRPALEKPHPHEEAT

SH3D21

456

A4FU49
EEPAPKHTARSLHPA

TAL1

306

P17542
HTPPSHSAKLLAEPS

FOXN1

496

O15353
RTPSSPHKKFSPSHS

SETD5

1121

Q9C0A6
SPPQHRPKTPSASSH

SPATA31C1

1171

P0DKV0
AKKSLSHPSHSRPGP

SPTY2D1

341

Q68D10
PEPHSHRGTDRKLSP

SPATC1L

121

Q9H0A9
HHESITPPSRSPTKE

SLX4

1671

Q8IY92
KDSPHPKHSLTTRLV

C12orf50

236

Q8NA57
NITIHKPASSPHSKP

CLEC16A

771

Q2KHT3
EAREHPTVVPSHKSP

CLCC1

451

Q96S66
DRLPHLHSKSKPSTT

SPATA2

441

Q9UM82
PRKHAEPSSSPSKVS

USP6NL

586

Q92738
PGEPAKPKTSAHHAT

RGS12

1431

O14924
PGTPHSHTKPYVRSK

RPL18

156

Q07020
RTPHSPPLAKEHASS

TNS4

346

Q8IZW8
HTTTLTPKPPSQALH

PLCB1

866

Q9NQ66
LRHTTENKPHSPKTP

PMS2

426

P54278
KTTSVHHRLPVQPDP

ZNF133

626

P52736
EHKEPTLPSDSPRHL

TNK1

86

Q13470
RHTTENKPHSPKTPE

PMS2CL

41

Q68D20
HPRTTGSHPKSENKI

TEX15

2356

Q9BXT5
KLSTSPDEPVPRSHH

SLC27A6

196

Q9Y2P4
STEVEPKESPHPARH

TEX2

196

Q8IWB9
SANLRPKTQPHHSTP

GTF3C1

501

Q12789
PSESPQHIAHPERKS

ZFYVE26

616

Q68DK2
HHVTVSPLRTDSPKA

HIVEP1

566

P15822
HPSKKRKHSESPPST

MYRF

251

Q9Y2G1