Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	S10_plectin	RPS10 PLEC	1.63e-05	2	76	2	PF03501
Domain	S10_plectin_N	RPS10 PLEC	1.63e-05	2	76	2	IPR005326
Domain	DOCK_N	DOCK3 DOCK4	1.62e-04	5	76	2	PF16172
Domain	DOCK_N	DOCK3 DOCK4	1.62e-04	5	76	2	IPR032376
Domain	RHD_dimer	RELB NFAT5	7.20e-04	10	76	2	IPR032397
Domain	RHD_dimer	RELB NFAT5	7.20e-04	10	76	2	PF16179
Domain	NFkB/Dor	RELB NFAT5	7.20e-04	10	76	2	IPR000451
Domain	REL_1	RELB NFAT5	7.20e-04	10	76	2	PS01204
Domain	RHD_DNA_bind_dom	RELB NFAT5	7.20e-04	10	76	2	IPR011539
Domain	RHD_DNA_bind	RELB NFAT5	7.20e-04	10	76	2	PF00554
Domain	REL_2	RELB NFAT5	7.20e-04	10	76	2	PS50254
Domain	-	RELB NFAT5	7.20e-04	10	76	2	2.60.40.340
Domain	DOCK_C	DOCK3 DOCK4	8.78e-04	11	76	2	IPR010703
Domain	DHR-1_domain	DOCK3 DOCK4	8.78e-04	11	76	2	IPR027007
Domain	DHR_2	DOCK3 DOCK4	8.78e-04	11	76	2	PS51651
Domain	DHR_1	DOCK3 DOCK4	8.78e-04	11	76	2	PS51650
Domain	DOCK-C2	DOCK3 DOCK4	8.78e-04	11	76	2	PF14429
Domain	DHR-2	DOCK3 DOCK4	8.78e-04	11	76	2	IPR027357
Domain	DHR-2	DOCK3 DOCK4	8.78e-04	11	76	2	PF06920
Domain	DOCK	DOCK3 DOCK4	8.78e-04	11	76	2	IPR026791
Domain	uDENN	DENND5B DENND5A	1.44e-03	14	76	2	SM00800
Domain	Kinase-like_dom	AXL BRSK2 EIF2AK4 RIPK4 FGFR4 BRSK1 TRRAP STK24	1.59e-03	542	76	8	IPR011009
Domain	uDENN	DENND5B DENND5A	1.66e-03	15	76	2	PF03456
Domain	UDENN	DENND5B DENND5A	1.89e-03	16	76	2	PS50946
Domain	DDENN	DENND5B DENND5A	1.89e-03	16	76	2	PS50947
Domain	DENN	DENND5B DENND5A	1.89e-03	16	76	2	SM00799
Domain	dDENN	DENND5B DENND5A	1.89e-03	16	76	2	SM00801
Domain	DENN	DENND5B DENND5A	1.89e-03	16	76	2	PF02141
Domain	dDENN_dom	DENND5B DENND5A	1.89e-03	16	76	2	IPR005112
Domain	uDENN_dom	DENND5B DENND5A	1.89e-03	16	76	2	IPR005113
Domain	dDENN	DENND5B DENND5A	1.89e-03	16	76	2	PF03455
Domain	DENN	DENND5B DENND5A	1.89e-03	16	76	2	PS50211
Domain	DENN_dom	DENND5B DENND5A	1.89e-03	16	76	2	IPR001194
Domain	RUN	DENND5B DENND5A	2.40e-03	18	76	2	SM00593
Domain	PROTEIN_KINASE_ATP	AXL BRSK2 EIF2AK4 RIPK4 FGFR4 BRSK1 STK24	2.63e-03	459	76	7	PS00107
Domain	RUN	DENND5B DENND5A	2.67e-03	19	76	2	PS50826
Domain	RUN	DENND5B DENND5A	2.67e-03	19	76	2	PF02759
Domain	Run_dom	DENND5B DENND5A	2.67e-03	19	76	2	IPR004012
Domain	PLAT	DENND5B DENND5A	3.26e-03	21	76	2	PS50095
Domain	-	DENND5B DENND5A	3.26e-03	21	76	2	2.60.60.20
Domain	PLAT	DENND5B DENND5A	3.26e-03	21	76	2	PF01477
Domain	PLAT/LH2_dom	DENND5B DENND5A	3.26e-03	21	76	2	IPR001024
Domain	Prot_kinase_dom	AXL BRSK2 EIF2AK4 RIPK4 FGFR4 BRSK1 STK24	3.73e-03	489	76	7	IPR000719
Domain	PROTEIN_KINASE_DOM	AXL BRSK2 EIF2AK4 RIPK4 FGFR4 BRSK1 STK24	3.89e-03	493	76	7	PS50011
Domain	Protein_kinase_ATP_BS	AXL BRSK2 EIF2AK4 FGFR4 BRSK1 STK24	4.45e-03	379	76	6	IPR017441
Domain	C2_dom	CEP120 PLCH1 TNS1 SYT13	4.50e-03	164	76	4	IPR000008
Domain	IPT	RELB NFAT5	5.37e-03	27	76	2	SM00429
Domain	TIG	RELB NFAT5	7.04e-03	31	76	2	PF01833
Domain	IPT	RELB NFAT5	7.49e-03	32	76	2	IPR002909
Pubmed	SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release.	BRSK2 BRSK1	5.09e-06	2	79	2	16630837
Pubmed	Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation.	BRSK2 BRSK1	5.09e-06	2	79	2	18339622
Pubmed	Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.	BRSK2 BRSK1	5.09e-06	2	79	2	30307479
Pubmed	Hundreds of variants clustered in genomic loci and biological pathways affect human height.	DOCK3 PCSK5 TET2 CEP120 FGFR4 TNS1	6.21e-06	198	79	6	20881960
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	AXL BRSK2 BOP1 CEP192 EIF2AK4 FGFR4 PLEC BRSK1 TRRAP TNS1 STK24	6.62e-06	910	79	11	36736316
Pubmed	Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells.	BRSK2 BRSK1	1.53e-05	3	79	2	22669945
Pubmed	Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity.	BRSK2 BRSK1	1.53e-05	3	79	2	20026642
Pubmed	Microtubule stabilization specifies initial neuronal polarization.	BRSK2 BRSK1	1.53e-05	3	79	2	18268107
Pubmed	The transcription factors NR5A1 and JUNB cooperate to activate the Axl promoter in mouse Sertoli cell lines.	JUNB AXL	1.53e-05	3	79	2	39271559
Pubmed	Bivariate genome-wide association study suggests fatty acid desaturase genes and cadherin DCHS2 for variation of both compressive strength index and appendicular lean mass in males.	DCHS2 FADS2	1.53e-05	3	79	2	22960237
Pubmed	TET2 promotes histone O-GlcNAcylation during gene transcription.	TET2 OGT	1.53e-05	3	79	2	23222540
Pubmed	PML Recruits TET2 to Regulate DNA Modification and Cell Proliferation in Response to Chemotherapeutic Agent.	TET2 OGT PLEC HSP90AB1	1.69e-05	67	79	4	29735542
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DOCK4 TET2 TRIP6 ARHGEF10 ZBTB21 BRSK2 CEP192 MPHOSPH9 PLEC PLCH1	2.53e-05	861	79	10	36931259
Pubmed	Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes.	ICAM2 ITGAL	3.05e-05	4	79	2	1448173
Pubmed	Tuberous sclerosis complex proteins control axon formation.	BRSK2 BRSK1	3.05e-05	4	79	2	18794346
Pubmed	Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked β-N-acetylglucosamine transferase (OGT).	TET2 OGT	3.05e-05	4	79	2	24394411
Pubmed	Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells.	TET2 OGT	3.05e-05	4	79	2	23352454
Pubmed	TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS.	TET2 OGT	3.05e-05	4	79	2	23353889
Pubmed	Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT).	TET2 OGT	3.05e-05	4	79	2	25568311
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	DOCK4 OGT TRIP6 DHX38 RPS10 ZBTB21 GEMIN4 ALG11 BOP1 TRRAP STK24 STRIP1	3.18e-05	1284	79	12	17353931
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	TET2 OGT ZBTB21 ETV3 RPRD2 MED13L	3.44e-05	268	79	6	33640491
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	TET2 OGT PLEC MED13L TRRAP HSP90AB1	3.73e-05	272	79	6	31010829
Pubmed	Identification of novel transcription-regulating genes expressed during murine molar development.	RPS10 RPS10P5 HSP90AB1	3.95e-05	29	79	3	22639370
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DOCK3 PCSK5 JUNB ZNF585A RELB CEP192 DENND5A PLEC MED13L CABIN1 TRRAP	3.97e-05	1105	79	11	35748872
Pubmed	Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function.	BRSK2 BRSK1	5.07e-05	5	79	2	15150265
Pubmed	Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis.	ICAM2 ITGAL	5.07e-05	5	79	2	32888431
Pubmed	C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.	BRSK2 BRSK1	5.07e-05	5	79	2	18854318
Pubmed	Manifestations of inflammatory arthritis are critically dependent on LFA-1.	ICAM2 ITGAL	5.07e-05	5	79	2	15749905
Pubmed	PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands.	TET2 OGT	5.07e-05	5	79	2	34667079
Pubmed	Defining the membrane proteome of NK cells.	ICAM2 DHX38 RPS10 GEMIN4 FADS2 PAM ALG11 MPHOSPH9 HEATR5B ITGAL HSP90AB1	6.54e-05	1168	79	11	19946888
Pubmed	HEY1 functions are regulated by its phosphorylation at Ser-68.	RPS10 CEP192 PLEC HSP90AB1	6.71e-05	95	79	4	27129302
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	ZNF618 RPS10 PLEC TRRAP HSP90AB1	6.96e-05	187	79	5	26460568
Pubmed	Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases.	ICAM2 ITGAL	7.60e-05	6	79	2	11857637
Pubmed	Lung ICAM-1 and ICAM-2 support spontaneous intravascular effector lymphocyte entrapment but are not required for neutrophil entrapment or emigration inside endotoxin-inflamed lungs.	ICAM2 ITGAL	7.60e-05	6	79	2	26823454
Pubmed	SAD kinases control the maturation of nerve terminals in the mammalian peripheral and central nervous systems.	BRSK2 BRSK1	7.60e-05	6	79	2	24395778
Pubmed	LKB1 and AMPK regulate synaptic remodeling in old age.	BRSK2 BRSK1	7.60e-05	6	79	2	25086610
Pubmed	STRIPAK components determine mode of cancer cell migration and metastasis.	STK24 STRIP1	7.60e-05	6	79	2	25531779
Pubmed	Mammalian SAD kinases are required for neuronal polarization.	BRSK2 BRSK1	7.60e-05	6	79	2	15705853
Pubmed	Phosphorylation of microtubule-associated protein tau by AMPK-related kinases.	BRSK2 BRSK1	7.60e-05	6	79	2	21985311
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	OGT ZBTB48 DHX38 GEMIN4 RPRD2 MED13L CABIN1	7.85e-05	453	79	7	29656893
Pubmed	Human transcription factor protein interaction networks.	TET2 JUNB OGT TRIP6 RPS10 ZBTB21 ETV3 RPRD2 RELB CEP192 CABIN1 TRRAP	8.86e-05	1429	79	12	35140242
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	OGT ARHGEF10 DHX38 BOP1 CEP192 EIF2AK4 MPHOSPH9 PLEC TRRAP STRIP1	9.21e-05	1005	79	10	19615732
Pubmed	Roles of tau protein in health and disease.	BRSK2 BRSK1 HSP90AB1	1.05e-04	40	79	3	28386764
Pubmed	Identification of a melanoma susceptibility locus and somatic mutation in TET2.	DOCK3 TET2	1.06e-04	7	79	2	24980573
Pubmed	Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome.	ZBTB21 RIPK4	1.06e-04	7	79	2	11528125
Pubmed	Putative tyrosine kinases expressed in K-562 human leukemia cells.	AXL FGFR4	1.06e-04	7	79	2	2247464
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PCSK5 OGT DHX38 PAM EIF2AK4 DENND5A PLCH1 CMTR2	1.16e-04	650	79	8	38777146
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DOCK3 TET2 DCHS2 OGT ARHGEF10 RIPK4 PLEC MED13L CABIN1 SLC4A3 HSP90AB1	1.52e-04	1285	79	11	35914814
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TET2 ZBTB21 BOP1 RPRD2 KDM7A EIF2AK4 SYT13	2.04e-04	529	79	7	14621295
Pubmed	Identification of 14-3-3epsilon substrates from embryonic murine brain.	OGT BRSK2 BRSK1 HSP90AB1	2.39e-04	132	79	4	16944949
Pubmed	Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival.	BRSK2 BRSK1	3.31e-04	12	79	2	23275438
Pubmed	Calreticulin Deficiency Disturbs Ribosome Biogenesis and Results in Retardation in Embryonic Kidney Development.	RPS10 RPS10P5	3.31e-04	12	79	2	34070742
Pubmed	Protein interactions of the transcription factor Hoxa1.	PCSK5 OGT TRIP6	3.87e-04	62	79	3	23088713
Pubmed	The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family.	DOCK3 DOCK4	3.91e-04	13	79	2	21930703
Pubmed	The loss of the kinases SadA and SadB results in early neuronal apoptosis and a reduced number of progenitors.	BRSK2 BRSK1	3.91e-04	13	79	2	29698519
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	OGT TRIP6 ARHGEF10 GNPDA2 DHX38 RPS10 BOP1 PLEC GMPPA STK24 HSP90AB1	4.39e-04	1455	79	11	22863883
Pubmed	Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.	BHMT2 FADS2	4.55e-04	14	79	2	23378610
Pubmed	Mechanical regulation of glycolysis via cytoskeleton architecture.	PLEC HSP90AB1	4.55e-04	14	79	2	32051585
Pubmed	Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.	DOCK3 DOCK4	4.55e-04	14	79	2	12432077
Pubmed	LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.	BRSK2 BRSK1	5.25e-04	15	79	2	14976552
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	OGT MED13L CABIN1 TRRAP	5.82e-04	167	79	4	20362541
Pubmed	Cell-free cotranslation and selection using in vitro virus for high-throughput analysis of protein-protein interactions and complexes.	JUNB SCHIP1	5.99e-04	16	79	2	15867431
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	PCSK5 TRIP6 MPHOSPH9 DENND5A PLEC	6.37e-04	302	79	5	30561431
Pubmed	O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.	OGT CABIN1	6.78e-04	17	79	2	27217568
Pubmed	Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis.	OGT HSP90AB1	6.78e-04	17	79	2	29208956
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	TET2 TRIP6 RPS10 ETV3 BOP1 PLEC HSP90AB1	7.30e-04	655	79	7	35819319
Pubmed	Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation.	DENND5B DENND5A	7.61e-04	18	79	2	32496646
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	OGT DHX38 BOP1 CEP192 EIF2AK4 PLEC NFAT5 TNS1 STK24	7.83e-04	1084	79	9	11544199
Pubmed	LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons.	BRSK2 BRSK1	8.50e-04	19	79	2	17482548
Pubmed	RIPK4 activity in keratinocytes is controlled by the SCFβ-TrCP ubiquitin ligase to maintain cortical actin organization.	RIPK4 HSP90AB1	8.50e-04	19	79	2	29435596
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DOCK3 ZNF618 DHX38 BRSK2 DDHD2 PLCH1	9.13e-04	493	79	6	15368895
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	RPUSD4 ECM2 LRRC1 GEMIN4 BOP1 PLEC	9.42e-04	496	79	6	31343991
Pubmed	Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.	BRSK2 BRSK1	9.43e-04	20	79	2	18227155
Pubmed	Evolutionary breakpoints on human chromosome 21.	ZBTB21 RIPK4	9.43e-04	20	79	2	11707078
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	DENND5B DOCK4 JUNB CEP120 ZBTB48 ZBTB21 RPRD2	9.81e-04	689	79	7	36543142
Pubmed	A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex.	GEMIN4 PLEC	1.04e-03	21	79	2	24923560
Pubmed	Prohibitin regulates TGF-beta induced apoptosis as a downstream effector of Smad-dependent and -independent signaling.	PLEC HSP90AB1	1.04e-03	21	79	2	19725029
Pubmed	Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels.	CYP27A1 FGFR4	1.04e-03	21	79	2	23747249
Pubmed	SAD kinases sculpt axonal arbors of sensory neurons through long- and short-term responses to neurotrophin signals.	BRSK2 BRSK1	1.25e-03	23	79	2	23790753
Pubmed	SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.	TET2 TRIP6 RPS10 PLEC HSP90AB1	1.28e-03	353	79	5	27545878
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	OGT AXL CYP27A1 PLEC	1.46e-03	214	79	4	22199357
Pubmed	The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex.	OGT PAM PLCH1	1.47e-03	98	79	3	19554387
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	OGT RPS10 BRSK2 RPS10P5 PLEC PLCH1 BRSK1 TNS1 STRIP1 HSP90AB1	1.47e-03	1431	79	10	37142655
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	OGT ZNF618 ZBTB21 BRSK1 CABIN1 TNS1 STRIP1 HSP90AB1	1.55e-03	963	79	8	28671696
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	PCSK5 ECM2 DPY19L4 GEMIN4 CEP192 SYT13 HSP90AB1	1.59e-03	750	79	7	11230166
Pubmed	Proximity interactions among centrosome components identify regulators of centriole duplication.	CEP120 CEP192 MPHOSPH9	1.60e-03	101	79	3	24613305
Pubmed	SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.	OGT TRIP6 DHX38 RPS10 PLEC HSP90AB1	1.72e-03	558	79	6	27591049
Pubmed	NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.	TET2 TRRAP	1.72e-03	27	79	2	23395962
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	TRIP6 DHX38 LRRC1 MPHOSPH9 HEATR5B	1.72e-03	378	79	5	34315543
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	DOCK3 ARHGEF10 CABIN1	1.74e-03	104	79	3	9205841
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	DENND5A MED13L PLCH1	1.74e-03	104	79	3	10470851
Pubmed	Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.	DOCK4 OGT RPS10 GEMIN4 HSP90AB1	1.83e-03	383	79	5	29331416
Pubmed	Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach.	TRIP6 STK24 HSP90AB1	1.84e-03	106	79	3	18654987
Pubmed	Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A.	DOCK3 FADS2	1.85e-03	28	79	2	19352218
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	DHX38 LRRC1 GEMIN4 HEATR5B STRIP1 HSP90AB1	1.96e-03	573	79	6	28330616
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	RPS10P5 PLEC TRRAP HSP90AB1	2.05e-03	235	79	4	30258100
Pubmed	14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.	BRSK2 BRSK1	2.13e-03	30	79	2	16306228
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	JUNB OGT DHX38 ZBTB21 BOP1 PLEC MED13L TRRAP	2.13e-03	1014	79	8	32416067
Pubmed	SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation.	OGT RPS10 GEMIN4 HSP90AB1	2.18e-03	239	79	4	23246001
Pubmed	Proteomic profiling of Myc-associated proteins.	MIPEP ETV3 TRRAP	2.26e-03	114	79	3	21150319
Cytoband	Ensembl 112 genes in cytogenetic band chr2q35	CYP27A1 GMPPA TNS1 SLC4A3	7.59e-05	129	79	4	chr2q35
CoexpressionAtlas	Myeloid Cells, DC.4+.SLN, CD11b-FITC CD4-PE CD11c-Alexa750 CD8a-PacificBlue, Lymph Node, avg-3	DOCK4 TET2 JUNB ST8SIA6 AXL CYP27A1 ETV3 RELB TNS1	1.63e-05	407	77	9	GSM538245_500
CoexpressionAtlas	DevelopingKidney_e15.5_early proxim tubul_emap-28005_k-means-cluster#4_top-relative-expression-ranked_500	ATP13A4 ST8SIA6 SLC15A2 BHMT2 FGFR4	3.82e-05	104	77	5	gudmap_developingKidney_e15.5_early proxim tubul_500_k4
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	JUNB ZBTB21 RELB DENND5A NFAT5 HSP90AB1	1.20e-06	192	79	6	6bba80887d6f64cf913a5c22f62baaddda417ce0
ToppCell	facs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SCHIP1 ECM2 CYP27A1 FADS2 FGFR4	1.72e-05	180	79	5	d33bb00f2b7d07dda9015cb8eafd742c2b2e9ace
ToppCell	P03\|World / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	JUNB OGT RPS10 FGFR4 TNS1	1.96e-05	185	79	5	a07dbe1f76e40734a28826423a5cc64b8e56af5e
ToppCell	CF-Myeloid-cDC\|CF / Disease state, Lineage and Cell class	ZNF618 AXL ETV3 EIF2AK4 L3MBTL4	1.96e-05	185	79	5	7f3d118845ff9f5f525796b0bbc6532a8ee323ab
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC15A2 TRIP6 FADS2 FGFR4 TNS1	2.12e-05	188	79	5	842982de2197770f999a70083ed9fca40ac22d79
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC15A2 TRIP6 FADS2 FGFR4 TNS1	2.12e-05	188	79	5	a0815eaf68eedd6e5ec4af520df80a6ab4eb0864
ToppCell	COPD-Myeloid-cDC2\|COPD / Disease state, Lineage and Cell class	DOCK4 TET2 AXL ETV3 EIF2AK4	2.29e-05	191	79	5	2af6e4a6bd1f2193ece2131c3b7d976dd23a6966
ToppCell	LA-14._Fibroblast_III\|LA / Chamber and Cluster_Paper	PCSK5 JUNB AXL RELB DENND5A	2.40e-05	193	79	5	7426c291bac59e539c427bcaae18abc7d397d44e
ToppCell	Control-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	DOCK4 TET2 PPP1R17 MED13L NFAT5	2.52e-05	195	79	5	b4444b67a709e82b8e2ee510924c3152cb88b051
ToppCell	mild_COVID-19-cDC\|World / disease group, cell group and cell class (v2)	SCHIP1 AXL ETV3 EIF2AK4 SLC4A3	2.65e-05	197	79	5	63e7b040c64f1e28b8db79980c7b580caa7d1b95
ToppCell	NS-control-d_0-4-Epithelial-Secretory\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TET2 SLC15A2 PAM NFAT5 TNS1	2.78e-05	199	79	5	32bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	ZNF618 DENND5A MED13L PLCH1 STK24	2.78e-05	199	79	5	358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCell	mild-cDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TET2 AXL ETV3 EIF2AK4 SLC4A3	2.85e-05	200	79	5	86f585bf9066b179bbcbc703bf43f15da4a07284
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DCHS2 ATP13A4 SLC15A2 ACOT6 PLCH1	2.85e-05	200	79	5	07d942803360e1a1e8e131d6e31c726dd0db1a0b
Disease	serine/threonine-protein kinase BRSK2 measurement	BRSK2 BRSK1	1.91e-05	3	75	2	EFO_0803063
Disease	SPARC-like protein 1 measurement	DHX38 NUDT9	9.50e-05	6	75	2	EFO_0008289
Disease	corpus callosum volume measurement	SCHIP1 BRSK2 PLEC L3MBTL4	1.25e-04	100	75	4	EFO_0010299
Disease	Gastric Adenocarcinoma	AXL BRSK1 TRRAP	2.07e-04	45	75	3	C0278701
Disease	head and neck squamous cell carcinoma (is_implicated_in)	JUNB FGFR4	6.55e-04	15	75	2	DOID:5520 (is_implicated_in)
Disease	hippocampal volume	BRSK2 PAM ACOT6 PLEC MED13L	9.70e-04	297	75	5	EFO_0005035
Disease	unipolar depression, bipolar disorder, schizophrenia	PCSK5 DCHS2	1.18e-03	20	75	2	EFO_0003761, MONDO_0004985, MONDO_0005090
Disease	haptoglobin measurement	DHX38 CMTR2	1.30e-03	21	75	2	EFO_0004640
Disease	cholelithiasis	FADS2 FGFR4 NFAT5	1.48e-03	88	75	3	EFO_0004799
Disease	apolipoprotein B measurement	PCSK5 DCHS2 RPUSD4 DHX38 FADS2 RELB PLEC	1.48e-03	663	75	7	EFO_0004615
Disease	lysophosphatidylcholine 18:0 measurement	FADS2 L3MBTL4	1.70e-03	24	75	2	EFO_0010359
Disease	alpha-linolenic acid measurement	CEP120 FADS2	1.84e-03	25	75	2	EFO_0007759
Disease	colon adenocarcinoma (is_marker_for)	PCSK5 TET2	1.84e-03	25	75	2	DOID:234 (is_marker_for)
Disease	Adenocarcinoma of lung (disorder)	JUNB SLC15A2 FGFR4 CMTR2	1.90e-03	206	75	4	C0152013
Disease	cerebellum cortex volume change measurement, age at assessment	PLCH1 STK24	1.99e-03	26	75	2	EFO_0008007, EFO_0021497
Disease	level of Sterol ester (27:1/18:2) in blood serum	FADS2 RELB	1.99e-03	26	75	2	OBA_2045194
Disease	level of Sterol ester (27:1/16:0) in blood serum	FADS2 RELB	1.99e-03	26	75	2	OBA_2045191
Disease	cortical surface area measurement	TET2 DCHS2 CEP120 BRSK2 FADS2 PAM MPHOSPH9 MED13L TNS1 STRIP1	2.10e-03	1345	75	10	EFO_0010736
Disease	corpus callosum mid-anterior volume measurement	BRSK2 PLEC	2.15e-03	27	75	2	EFO_0010297

Protein segments in the cluster

Peptide	Gene	Start	Entry
RHMHPKKGLLPRDQD	SYT13	31	Q7L8C5
AVLGRHKMHVPAPKL	BOP1	291	Q14137
HKMHVPAPKLALPGH	BOP1	296	Q14137
PLHEKKMTPGHLLVS	ALG11	291	Q2TAA5
MPAKHHPEQPYVTKV	SLC4A3	1136	P48751
HIKKEKHPLLVGHMP	ARHGEF10	871	O15013
EHNKPPPKSFHEEML	EIF2AK4	136	Q9P2K8
DFHIKGVPAHAMVVK	ATP13A4	566	Q4VNC1
GHQKRKPDIMLPLFA	ETV3	221	P41162
HPQRMEKKLHAVPAG	FGFR4	151	P22455
MKRKALFPHHVIPDS	CMTR2	341	Q8IYT2
AVDFMLQHPKVKGPS	ACOT6	211	Q3I5F7
IFKPVRKHFDMPHDI	PAM	771	P19021
PVLLVHGMHDKFVPV	ABHD8	361	Q96I13
KKKPAILDHFLPNHG	RELB	436	Q01201
HAKPNIFHKDPDVNM	FADS2	221	O95864
GQLKKPFIPIHHMEA	OSGEPL1	136	Q9H4B0
MAKKHLEINPDHPIV	HSP90AB1	621	P08238
LEKHGFDVPIMVPKL	KDM7A	151	Q6ZMT4
GKIPPKLHNHMVHRV	MED13L	366	Q71F56
EKVKRGVFHMPHFIP	BRSK2	226	Q8IWQ3
KCQMQPGHPLFLHEG	PCSK5	1246	Q92824
KIMHPVSGKHILQFV	NUDT9	186	Q9BW91
LHGLVMPVHAQKKPS	FAM205A	1191	Q6ZU69
EFEPMLIPHHKGRKR	DDHD2	556	O94830
LHMKPKQQISGIQPH	MPHOSPH9	296	Q99550
NAVPAKVFKMRLPHG	L3MBTL4	281	Q8NA19
MELFHQNHLIVKVPP	NFAT5	496	O94916
PHPGELKHMKKTVEN	LRRC1	481	Q9BTT6
MLKGVIKEHKDHFPP	MAGEA13P	131	A6NCF6
IKEHKDHFPPIFMQA	MAGEA13P	136	A6NCF6
KLKDEHLHMPGIPKE	DCHS2	3256	Q6V1P9
HLHMPGIPKEKKSFV	DCHS2	3261	Q6V1P9
KPLFPVAGVPMIQHH	GMPPA	26	Q96IJ6
AVHKLIFPSMGPEHE	IGSF22	566	Q8N9C0
HQCPLGIPHAKGKMV	HEATR5B	516	Q9P2D3
LKAHLMVQPLGFHAP	BHMT2	231	Q9H2M3
KKIHYHNPPELAMEA	CABIN1	1246	Q9Y6J0
EHKIHFIPGMIGPFL	DOCK3	1086	Q8IZD9
GLAVHEKFVHPEMRP	DOCK3	1596	Q8IZD9
HEKFVPQDMRPLHKK	DOCK4	1561	Q8N1I0
EGRHFPKRPKHMLVV	CEP120	16	Q8N960
AGQVPQHKDFAHMPL	CYP27A1	371	Q02318
PHKENGHMLKFLEVK	DPY19L4	371	Q7Z388
IHPHLLDMKIGQGKY	DENND5B	636	Q6ZUT9
IHPHLLDMKIGQGKY	DENND5A	651	Q6IQ26
EKVKRGVFHMPHFIP	BRSK1	241	Q8TDC3
KSIPPGIQEMKALHF	ECM2	621	O94769
KGLMHVHNKLVDPLF	GNPDA2	256	Q8TDQ7
LHKPEMIKQILPEHS	CEP192	2001	Q8TEP8
HPLKEPHMKHTLRFQ	CEP192	2371	Q8TEP8
PSLEMKIHNFLKGNP	RPRD2	666	Q5VT52
GPADKHIPHIQGNMI	SLC15A2	706	Q16348
HYAAGNKPDHMIKPV	OGT	1026	O15294
LPILAKMLHGHKAEP	RPUSD4	131	Q96CM3
KKSPVADLLPHMPHI	SCHIP1	391	P0DPB3
HSELHPMKVLFLIPK	STK24	231	Q9Y6E0
TVPKLKELHVHPPGM	SLITRK3	906	O94933
GHAPHFPMKKVLLLL	STRIP1	276	Q5VSL9
DNKLPKHGFHQMPKE	ST8SIA6	361	P61647
PKDHHFDMINIKSIP	NDUFAF4	96	Q9P032
GNIFHKHSAPKMLEI	ICAM2	201	P13598
PKGPKIHQVKHMYQV	ITGAL	941	P20701
HIMVKVVKGHRPELP	RIPK4	231	P57078
FEKPNQGMVVHLLKP	SH2D1B	86	O14796
VQERHPKGKMIPVLH	PPP1R17	91	O96001
DVHMPKHPELADKNV	RPS10	26	P46783
HMIKLHGAPKPHACP	ZBTB48	396	P10074
LGDLMEHLVPHPEFK	TUBD1	256	Q9UJT1
KQHIKMHPGEKPLGV	ZBTB21	686	Q9ULJ3
KKLVHDMNHPPSGEY	TRIP6	261	Q15654
FKVHPAHKVAMILDP	ZNF618	796	Q5T7W0
MGTNFPNKIEKHLLP	MIPEP	221	Q99797
DVHMPKHPELADKNV	RPS10P5	26	Q9NQ39
NKPLFLHHVIMHGIP	TNS1	181	Q9HBL0
PVVILPFMKHGDLHS	AXL	616	P30530
NAAKVHLMVHNLVPP	DHX38	401	Q92620
KAVVQLKPRHPAHPM	PLEC	926	Q15149
QDMHVPVPKQLAHLP	PLCH1	1466	Q4KWH8
PEFIIHQKTHMREKP	ZNF585A	171	Q6P3V2
HTLPPKVFEMLLHKI	TOMM20L	116	Q6UXN7
QMHRPIKVEPGCKPH	TET2	976	Q6N021
PHKEVLQDMVPPKKH	TRRAP	1281	Q9Y4A5
RSHMGKLKEPQPQDH	UNQ9165/PRO28630	116	Q6UXU0
EVMKHKGHPQDPLLS	GEMIN4	166	P57678
KALDDLHKMNHVTPP	JUNB	141	P17275