Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domain-

USP54 CAPN7

2.19e-04133221.20.58.280
DomainMIT

USP54 CAPN7

2.55e-0414322IPR007330
DomainGUANYLATE_KINASE_2

MAGI1 LRGUK

7.04e-0423322PS50052
DomainGUANYLATE_KINASE_1

MAGI1 LRGUK

7.04e-0423322PS00856
DomainGuanylate_kin

MAGI1 LRGUK

9.01e-0426322PF00625
DomainGK/Ca_channel_bsu

MAGI1 LRGUK

9.01e-0426322IPR008145
DomainGuanylate_kin-like_dom

MAGI1 LRGUK

9.01e-0426322IPR008144
DomainGuKc

MAGI1 LRGUK

9.01e-0426322SM00072
DomainSH2

TNS2 STAT1

1.29e-02101322PF00017
PathwayWP_TROP2_REGULATORY_SIGNALING

CDKN1B STAT1 CLDN1

7.59e-0549243M46458
Pubmed

Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1.

PIAS4 CBX4 UBR5

3.95e-08832320351170
Pubmed

[Expression and relationship of p27(kip1) and its nuclear export factor Jab1 in lymphoma cell Jurkat].

CDKN1B COPS5

8.20e-07232218476592
Pubmed

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1.

CDKN1B COPS5

8.20e-07232210086358
Pubmed

Jun activation domain-binding protein 1 expression in malignant lymphoma of the thyroid: its linkage to degree of malignancy and p27 expression.

CDKN1B COPS5

8.20e-07232214666612
Pubmed

Expression of cell cycle inhibitor p27Kip1 and its inactivator Jab1 in melanocytic lesions.

CDKN1B COPS5

8.20e-07232215154004
Pubmed

Jun activation domain-binding protein 1 expression in oral squamous cell carcinomas inversely correlates with the cell cycle inhibitor p27.

CDKN1B COPS5

8.20e-07232222311264
Pubmed

Stat1 phosphorylation determines Ras oncogenicity by regulating p27 kip1.

CDKN1B STAT1

8.20e-07232218941537
Pubmed

JAB1 and phospho-Ser10 p27 expression profile determine human hepatocellular carcinoma prognosis.

CDKN1B COPS5

8.20e-07232224671224
Pubmed

Significance of Jab1 expression in human esophageal squamous cell carcinoma.

CDKN1B COPS5

8.20e-07232219349901
Pubmed

[Expression and their significance of Jab1 p27kip1 in laryngeal squamous cell carcinoma and Hep-2 cells].

CDKN1B COPS5

8.20e-07232222675932
Pubmed

Adhesion to fibronectin induces p27(Kip1) nuclear accumulation through down-regulation of Jab1 and contributes to cell adhesion-mediated drug resistance (CAM-DR) in RPMI 8,226 cells.

CDKN1B COPS5

8.20e-07232224170542
Pubmed

Jab1/CSN5 negatively regulates p27 and plays a role in the pathogenesis of nasopharyngeal carcinoma.

CDKN1B COPS5

8.20e-07232222350412
Pubmed

14-3-3 sigma possibly plays a constitutive role in papillary carcinoma, but not in follicular tumor of the thyroid.

CDKN1B COPS5

8.20e-07232212860294
Pubmed

Prognostic significance of localized p27Kip1 and potential role of Jab1/CSN5 in pancreatic cancer.

CDKN1B COPS5

8.20e-07232214719054
Pubmed

Cytoplasmic localization of Jab1 and p27 Kip1 might be associated with invasiveness of papillary thyroid carcinoma.

CDKN1B COPS5

8.20e-07232219461157
Pubmed

[Expression and significance of Ser10 phosphorylated p27(kip1) and JAB1 protein in human hepatocellular carcinoma].

CDKN1B COPS5

8.20e-07232218346358
Pubmed

MicroRNA-1224 Splicing CircularRNA-Filip1l in an Ago2-Dependent Manner Regulates Chronic Inflammatory Pain via Targeting Ubr5.

AGO2 UBR5

8.20e-07232230651325
Pubmed

Expression of p27 and Jun activation domain-binding protein 1 in endometriosis.

CDKN1B COPS5

8.20e-07232225666480
Pubmed

JAB1 expression is associated with inverse expression of p27(kip1) in hepatocellular carcinoma.

CDKN1B COPS5

8.20e-07232220698225
Pubmed

Interaction of the stress protein p8 with Jab1 is required for Jab1-dependent p27 nuclear-to-cytoplasm translocation.

CDKN1B COPS5

2.46e-06332216300740
Pubmed

Clinicopathological significance of expression of Tspan-1, Jab1 and p27 in human hepatocellular carcinoma.

CDKN1B COPS5

2.46e-06332220890423
Pubmed

[Expression and relationship of p27(kip1) and its related molecules Jab1 and CRM1 during proliferation of lymphoma cells U937].

CDKN1B COPS5

2.46e-06332218246793
Pubmed

S100A7, Jab1, and p27kip1 expression in psoriasis and S100A7 CRISPR-activated human keratinocyte cell line.

CDKN1B COPS5

2.46e-06332230203426
Pubmed

Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1.

CDKN1B COPS5

2.46e-06332212119282
Pubmed

Rare sugar D-allose induces specific up-regulation of TXNIP and subsequent G1 cell cycle arrest in hepatocellular carcinoma cells by stabilization of p27kip1.

CDKN1B COPS5

2.46e-06332218202760
Pubmed

Skp2 and Jab1 expression are associated with inverse expression of p27(KIP1) and poor prognosis in oral squamous cell carcinomas.

CDKN1B COPS5

2.46e-06332214707456
Pubmed

Potential role of Jun activation domain-binding protein 1 as a negative regulator of p27kip1 in pancreatic adenocarcinoma.

CDKN1B COPS5

2.46e-06332216951171
Pubmed

Gfer inhibits Jab1-mediated degradation of p27kip1 to restrict proliferation of hematopoietic stem cells.

CDKN1B COPS5

2.46e-06332221346186
Pubmed

STAT1 represses Skp2 gene transcription to promote p27Kip1 stabilization in Ras-transformed cells.

CDKN1B STAT1

2.46e-06332220407011
Pubmed

Thioredoxin modulates activator protein 1 (AP-1) activity and p27Kip1 degradation through direct interaction with Jab1.

CDKN1B COPS5

4.92e-06432215480426
Pubmed

COPS5 inhibition arrests the proliferation and growth of serous ovarian cancer cells via the elevation of p27 level.

CDKN1B COPS5

4.92e-06432228919423
Pubmed

Jun activation domain-binding protein 1 negatively regulate p27 kip1 in non-Hodgkin's lymphomas.

CDKN1B COPS5

4.92e-06432218285702
Pubmed

Expression of Jun activation domain-binding protein 1 and Ser10 phosphorylated p27 protein in human epithelial ovarian carcinoma.

CDKN1B COPS5

4.92e-06432219139918
Pubmed

Hepatitis B virus pre-S2 mutant surface antigen induces degradation of cyclin-dependent kinase inhibitor p27Kip1 through c-Jun activation domain-binding protein 1.

CDKN1B COPS5

4.92e-06432217951406
Pubmed

The p90 ribosomal S6 kinase-UBR5 pathway controls Toll-like receptor signaling via miRNA-induced translational inhibition of tumor necrosis factor receptor-associated factor 3.

AGO2 UBR5

8.19e-06532228559278
Pubmed

Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair.

CDKN1B COPS5

8.19e-06532220802511
Pubmed

Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1).

CDKN1B COPS5

8.19e-06532212082530
Pubmed

ELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages.

CDKN1B AGO2

8.19e-06532225533351
Pubmed

BAG3 promotes proliferation of ovarian cancer cells via post-transcriptional regulation of Skp2 expression.

CDKN1B AGO2

8.19e-06532228624440
Pubmed

Multiple functions of Jab1 are required for early embryonic development and growth potential in mice.

CDKN1B COPS5

1.23e-05632215299027
Pubmed

Jab1 regulates Schwann cell proliferation and axonal sorting through p27.

CDKN1B COPS5

1.23e-05632224344238
Pubmed

Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.

MAGI1 ATN1

1.23e-0563229647693
Pubmed

Inhibition of Stat1-mediated gene activation by PIAS1.

PIAS4 STAT1

1.72e-0573229724754
Pubmed

Cep78 controls centrosome homeostasis by inhibiting EDD-DYRK2-DDB1VprBP.

CEP78 UBR5

1.72e-05732228242748
Pubmed

HIV-1 Vpr hijacks EDD-DYRK2-DDB1DCAF1 to disrupt centrosome homeostasis.

CEP78 UBR5

1.72e-05732229724823
Pubmed

Constitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicity.

CDKN1B COPS5

1.72e-05732215688030
Pubmed

A Hypoxia-Induced SCFFBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis.

CDKN1B UBR5 COPS5

1.80e-055532334237211
Pubmed

Structural basis for a reciprocal regulation between SCF and CSN.

CDKN1B COPS5

2.94e-05932222959436
Pubmed

SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage.

PIAS4 CBX4

3.67e-051032218408014
Pubmed

The Antioxidant Enzyme Methionine Sulfoxide Reductase A (MsrA) Interacts with Jab1/CSN5 and Regulates Its Function.

CDKN1B COPS5

3.67e-051032232456285
Pubmed

HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells.

PIAS4 CBX4

4.49e-051132228842558
Pubmed

The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex.

CDKN1B COPS5

5.38e-051232211704659
Pubmed

Ser727/Tyr701-phosphorylated Stat1 is required for the regulation of c-Myc, cyclins, and p27Kip1 associated with ATRA-induced G0/G1 arrest of U-937 cells.

CDKN1B STAT1

5.38e-051232212637327
Pubmed

BMI1-UBR5 axis regulates transcriptional repression at damaged chromatin.

CBX4 UBR5

6.36e-051332227647897
Pubmed

Latent CSN-CRL complexes are crucial for curcumin-induced apoptosis and recruited during adipogenesis to lipid droplets via small GTPase RAB18.

CDKN1B COPS5

8.55e-051532237091236
Pubmed

Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.

CBX4 CLDN1

1.11e-041732223362346
Pubmed

Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5.

CEP78 UBR5

1.24e-041832228689657
Pubmed

BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways.

CDKN1B STAT1

1.70e-042132217065231
Pubmed

HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly.

SOX6 CDKN1B

1.70e-042132234928956
Pubmed

Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.

SOX6 FGFRL1

1.70e-042132224249740
Pubmed

Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs.

SOX6 ELN

1.87e-042232227527664
Pubmed

Ets1 is required for proper migration and differentiation of the cardiac neural crest.

SOX6 ELN

1.87e-042232220356956
Pubmed

Cartilage-specific overexpression of ERRγ results in Chondrodysplasia and reduced chondrocyte proliferation.

SOX6 CDKN1B

2.05e-042332224349082
Pubmed

Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes.

AGO2 ATN1

2.05e-042332220696395
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

TNS2 USP54 ATN1 COPS5 AHDC1

2.19e-0460832516713569
Pubmed

Shp2 in myocytes is essential for cardiovascular and neointima development.

CDKN1B ELN

2.24e-042432231634485
Pubmed

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

CD46 ZNF670 UBR5 G6PD

2.24e-0432732415592455
Pubmed

High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.

PIAS4 TNS2 SGCE ATN1 AHDC1 PRR7

2.97e-04102132626760575
Pubmed

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.

PIAS4 CBX4 UBR5 G6PD

3.13e-0435732437059091
Pubmed

Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis.

CDKN1B STAT1

3.28e-042932214522949
Pubmed

Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1.

CDKN1B ATN1

3.75e-043132216702404
Pubmed

Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.

CD46 ELN

4.00e-043232218842294
Pubmed

Phospho-tyrosine dependent protein-protein interaction network.

TNS2 ZNF670 AHDC1 STAT1

5.27e-0441032425814554
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

PIAS4 FGFRL1 CD46 CBX4 ATN1 STAT1

7.08e-04120332629180619
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

PIAS4 CBX4 AHDC1 STAT1

7.10e-0444432434795231
Pubmed

EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice.

STAT1 CLDN1

7.57e-044432235493520
Pubmed

mTORC1 accelerates retinal development via the immunoproteasome.

CDKN1B STAT1

8.28e-044632229950673
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

MAGI1 AGO2 ATN1 G6PD AHDC1 STAT1

8.54e-04124732627684187
GeneFamilySH2 domain containing

TNS2 STAT1

3.98e-03101172741
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CDKN1B PIAS4 FGFRL1 C9orf152

4.76e-06157324ffb8dd381e6b9adc5283fb49586e8bd63773c8d6
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CDKN1B PIAS4 FGFRL1 C9orf152

4.76e-06157324c488ab1d6c6c7e5c2f4426805d1366b44711a031
ToppCellParenchymal-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SOX6 SGCE USP54 CLDN1

1.24e-052003248a4c210a3130f7baedf15ecbc0f4903b97da0352
ToppCellhealthy_donor-Lymphocytic-T_cell-CD4+_T_cell_(ISG_high)|healthy_donor / Disease condition, Lineage, Cell class and subclass

SOX6 MAGI1 STAT1

1.31e-0413832397f5dc17522462133e582b508ad0ef036e656872
ToppCell367C-Myeloid-Macrophage-SPP1+_Macrophage_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

C9orf152 AHDC1 CLDN1

1.49e-041443233ba7f8bd6d1c551048403c94693d63e60f7cbbb7
ToppCell367C-Myeloid-Macrophage-SPP1+_Macrophage_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

C9orf152 AHDC1 CLDN1

1.49e-0414432338ff324366ad5be626e3657c1e33277fc36ddd4c
ToppCellIIH-CD8-proli_CD4|IIH / Condition, Cell_class and T cell subcluster

PIAS4 USP54 SULT2B1

1.55e-041463237fa6e35def3f7cffbee1e1c2f10b523bab678e14
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SGCE ELN USP54

1.61e-041483231186ee0d15244fee74c1d09df3967c1b69f8ddce
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

USP54 ZNF670 PRR7

1.92e-041573234766f7d545bf2d775390589460677519cb92f4d5
ToppCellAdult-Mesenchymal-myofibroblast_cell-D122|Adult / Lineage, Cell type, age group and donor

C4orf51 HPSE2 ELN

1.96e-04158323410fa08c9d880d27e80ec939fa5ba5a41dcb31ab
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI1 CEP78 CLDN1

2.22e-04165323dc570154baed59ed109e5369589448e075ba66a9
ToppCellfacs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l34|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SOX6 MYOZ3 FGFRL1

2.30e-04167323102b3d160a44c8623fab1fd10e9054178c42a78b
ToppCellT_cells-GNLY+GZMB+_T_cells|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

CEP78 ZNF670 CLDN1

2.47e-0417132304c811817cfec45af5f2891793106cc7ddb0300e
ToppCelldroplet-Marrow-BM-1m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AHDC1 CLDN1 PRR7

2.64e-04175323c1c722db42da9b8a2a46e516ddb83d9be5e2e504
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Proximal_secretory_3|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

USP54 SULT2B1 CLDN1

2.69e-041763238d9d0fb46c418b2067be58aec822e8c2b1561461
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SOX6 PCARE HPSE2

2.73e-0417732391706bd0d4dda8d98843fb00b898d5aca4d66b64
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

MAGI1 SGCE USP54

2.82e-04179323cb38b54261a7af5ee3347e64c8aa880a77ed0763
ToppCellmetastatic_Brain-Endothelial_cells-Lymphatic_ECs|metastatic_Brain / Location, Cell class and cell subclass

MYOZ3 ELN ZNF670

2.82e-0417932356fe381ffbaba3a4f2f587a3e367b0d11fbd4a2a
ToppCellfacs-Lung-EPCAM-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI1 HPSE2 ELN

2.87e-04180323d67d3196e6cc3dcd31023a4dc69310226181d583
ToppCellfacs-Lung-EPCAM-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI1 HPSE2 ELN

2.87e-04180323573308d43425d9fba20787abdb7f8efefc48efb5
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

MAGI1 USP54 SULT2B1

2.96e-04182323215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCellCOVID-19-kidney-CD-IC-B|COVID-19 / Disease (COVID-19 only), tissue and cell type

SOX6 MAGI1 CLDN1

2.96e-04182323ee6a8c356bbbdae55e4ea858337e079491f9f4aa
ToppCell3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C4orf51 HPSE2 ELN

3.11e-041853237b1c5d99bd7a6e148524029758cee244a17f5d09
ToppCell3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C4orf51 HPSE2 ELN

3.11e-04185323e9033a03d574956cf3ae228740b3166e40a6397f
ToppCellMild_COVID-19-Epithelial-AT1/AT2|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

C9orf152 LRGUK CLDN1

3.11e-04185323c55fdba1e3818ec0404d7ab473bf18dd25f2bb0a
ToppCell3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C4orf51 HPSE2 ELN

3.11e-04185323578f12c6b2e33d09598dc8e022a20c8555d1325c
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SOX6 PCARE HPSE2

3.16e-04186323948815663c212c4311329d503b5991cbbbff9808
ToppCellCOVID-19-kidney-CD-IC-B|kidney / Disease (COVID-19 only), tissue and cell type

MAGI1 CEP78 CLDN1

3.21e-04187323ce05b89860573fe0356102e2998d1ef6d1968034
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SOX6 PCARE HPSE2

3.26e-0418832372cbfe9dc0583dbeafa6cb0945fa370d0c808284
ToppCell-Unknown-Endothelial-Myofibroblast| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HPSE2 ELN UBR5

3.26e-041883236468fa95ad0395395301115286f2d8c0df5d3882
ToppCell-Unknown-Endothelial| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HPSE2 ELN UBR5

3.26e-041883237a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCellMesenchymal-chondrocyte|World / Lineage, Cell type, age group and donor

SOX6 FGFRL1 ELN

3.26e-041883237b1e3f8a941eaa68e89c562129a92314642eec66
ToppCell-Unknown| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HPSE2 ELN UBR5

3.26e-041883239cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HPSE2 ELN CLDN1

3.26e-04188323293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCellE12.5-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SOX6 FGFRL1 ELN

3.26e-041883239b95730ddd13eb4624321bab3ab4989414977ca3
ToppCellSupraBC-Differ-KC|World / shred by cell class for mouse tongue

MAGI1 SULT2B1 CLDN1

3.31e-041893236412741b88e241304033b41effca0c77a374d907
ToppCell5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C9orf152 SULT2B1 CLDN1

3.31e-04189323453b2acfa89e7279540109244cf986df34635df8
ToppCellMS-CD8-antiviral_CD4|MS / Condition, Cell_class and T cell subcluster

GLMP ATN1 STAT1

3.36e-041903238c831c4560b8e70f92b4c15644fea39f7f7afcf2
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SOX6 MAGI1 USP54

3.41e-0419132334cc997e4e5c727495f321e6807a84aa124da486
ToppCell15-Airway-Epithelial-Secretory_progenitor|Airway / Age, Tissue, Lineage and Cell class

C9orf152 USP54 SULT2B1

3.41e-041913239359d8c6b00f8977848986baf3c950157adf4c9a
ToppCellIPF-Epithelial-Club|World / Disease state, Lineage and Cell class

MAGI1 USP54 CLDN1

3.41e-041913233c88a6f1d74bb3b9173cd0ea3a63c6d9570e3954
ToppCellCOPD-Epithelial|COPD / Disease state, Lineage and Cell class

MAGI1 USP54 CLDN1

3.46e-041923230644fad5df18f0021f6f49cca996d8cf47f972ff
ToppCell18-Distal-Mesenchymal-Cartilage|Distal / Age, Tissue, Lineage and Cell class

SOX6 FGFRL1 ELN

3.52e-0419332352f3d1bb8d8ca91ba12439d46392f377928ff8f8
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HPSE2 ELN CLDN1

3.52e-04193323cfab88935abe0a15632c5eec8ff00a857ec9b3ed
ToppCelldroplet-Tongue-nan-3m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAGI1 SULT2B1 CLDN1

3.52e-04193323a7002acf3be76b2cc6fc9364176f6b0d3bd27d9c
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

MAGI1 LRGUK USP54

3.62e-04195323fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

MAGI1 LRGUK USP54

3.62e-04195323eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Smooth_muscle|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNS2 SGCE ELN

3.68e-0419632369ad90a429af4dad5a45556544224001ebcb1607
ToppCell3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Smooth_muscle-Smooth_muscle_L.2.3.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNS2 SGCE ELN

3.68e-041963234da96672a9c72268cfcc82d61eb3caae6e02d4c4
ToppCell3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNS2 SGCE ELN

3.68e-04196323f78951b460913866d092ba92af70ea76a2afa73e
ToppCelldistal-mesenchymal-Vascular_Smooth_Muscle-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SOX6 SGCE ELN

3.73e-04197323da653dc7d216e202f390e5ab0245f243e3ed213b
ToppCellfacs-Heart-RV-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDKN1B TNS2 SGCE

3.73e-04197323a2d9d3098e5103290b434919dbbc40d7e79fcae0
ToppCelldistal-2-mesenchymal-Vascular_Smooth_Muscle|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SOX6 SGCE ELN

3.79e-04198323ce05ede69c167b2294630709bb0c223483a6ef75
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HPSE2 ELN CLDN1

3.79e-0419832363f7d25201613bd3404c28fb936954190bca91d3
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HPSE2 ELN CLDN1

3.79e-04198323a73534b6ca202c277a70a52281d5b97a3e6cb8ef
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_secretory-Secretory_Goblet|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

FGFRL1 C9orf152 SULT2B1

3.79e-041983235dd2aa7684c36beffa204ca4c04d0501cabac10f
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HPSE2 ELN CLDN1

3.79e-04198323d1e1bdd36c84e1bac21ba137f018defe98456a8c
ToppCelldistal-mesenchymal-Vascular_Smooth_Muscle|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SOX6 SGCE ELN

3.79e-041983238d1c74a728040386316fbdcabcdea5fb2b5a76a1
ToppCell18-Airway-Mesenchymal-Cartilage|Airway / Age, Tissue, Lineage and Cell class

SOX6 FGFRL1 ELN

3.85e-04199323f5d0aa4170367c080d3c2f01d9af3529762917fa
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SGCE HPSE2 ELN

3.85e-0419932384545ced0c792bc77980a50d65e484eab648d47e
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal-Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SOX6 ELN CLDN1

3.85e-0419932394a7867e800df352731796de8c24cba133c29622
ToppCellmedial-mesenchymal-Vascular_Smooth_Muscle|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SOX6 SGCE ELN

3.85e-0419932374fe1737a0d63ef0bc49312f1b5823b5c39590dd
ToppCellproximal-Epithelial-Differentiating_Basal-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

C9orf152 SULT2B1 CLDN1

3.85e-04199323c607346f60e5997e757e5a31cab412ab3734377b
ToppCellmedial-mesenchymal-Vascular_Smooth_Muscle-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SOX6 SGCE ELN

3.85e-04199323263603264ff40ea8ef569cb43f8b84b5938438ab
ToppCellproximal-3-Epithelial-Differentiating_Basal|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

C9orf152 SULT2B1 CLDN1

3.85e-0419932312e07084fc2d5d4c418df564ccc0e132b056e549
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

HPSE2 ELN CLDN1

3.85e-04199323e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCelldistal-2-mesenchymal-Airway_Smooth_Muscle|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SOX6 SGCE ELN

3.85e-04199323af226a6c50747dad9ca696463e715913b3ac17c0
ToppCellproximal-Epithelial-Differentiating_Basal|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

C9orf152 SULT2B1 CLDN1

3.85e-0419932396a89a2578fad9a99c52d2cf9e26e06516a96568
ToppCellmedial-2-mesenchymal-Vascular_Smooth_Muscle|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SOX6 SGCE ELN

3.85e-041993238ce0bcc53b3a955285d614459e45210104a6ed02
ToppCellfacs-Trachea-nan-3m-Mesenchymal|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGFRL1 TNS2 SGCE

3.85e-0419932367f78c070c56e44fba36542041bf7fa1c291807c
ToppCellPSB-critical-LOC-Epithelial-Basal|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ELN SULT2B1 CLDN1

3.85e-041993232add64c3e4cb6384ec381f34c3f1f77e13e3f27c
ToppCellfacs-Trachea-nan-3m-Mesenchymal-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGFRL1 TNS2 SGCE

3.85e-041993231ae244b563f85c1ee8d22698f478c842a4d9c7f5
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_basal-Suprabasal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

C9orf152 SULT2B1 CLDN1

3.90e-042003235f0f67958c9635db53e61f8370a92da6ea3e80fe
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB|Neuronal / cells hierarchy compared to all cells using T-Statistic

SOX6 MAGI1 HPSE2

3.90e-04200323e79d93d55b25804f2608185168da472301b6ebca
ToppCell10x3'2.3-week_12-13-Mesenchymal_fibro-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TNS2 SGCE ELN

3.90e-0420032364d2941689d7ca8af54f9ba21c5aeabf719084ef
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TNS2 HPSE2 ELN

3.90e-042003233dacd0afe69bc16bb33336ea9ea99a9cd47731d9
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

HPSE2 ELN CLDN1

3.90e-04200323c5e051f1aac8dda376c342a9932785a23450e073
ToppCell10x3'2.3-week_12-13-Mesenchymal_fibro-stroma-arteriolar_fibroblast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TNS2 SGCE ELN

3.90e-04200323fee22a6a6c7b93af204b5b56f2c34f1411500e18
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

HPSE2 ELN CLDN1

3.90e-042003239d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB--L2-4|Neuronal / cells hierarchy compared to all cells using T-Statistic

SOX6 MAGI1 HPSE2

3.90e-042003235ec469267747dce3601c1d8ad01af89fa5b29acc
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_airway_basal-Suprabasal|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

C9orf152 SULT2B1 CLDN1

3.90e-04200323d536180a308abc5703d5c8bb33dfe57dc4cc6577
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TNS2 HPSE2 ELN

3.90e-04200323ac8a5d71acd4d401995babd233f0d3738e8ad2a5
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

HPSE2 ELN CLDN1

3.90e-04200323c596a53c0b63c9deaac7d99fcbdd94ecfa96b86c
ToppCell10x3'2.3-week_12-13-Mesenchymal_fibro|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TNS2 SGCE ELN

3.90e-0420032376f3043cb88071256ff661885fe5a82a54f5b733
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB-|Neuronal / cells hierarchy compared to all cells using T-Statistic

SOX6 MAGI1 HPSE2

3.90e-04200323320d5a3a1e7da2fa8f1a164e29e180ec8ac9889c
Diseasehepatocellular carcinoma (is_marker_for)

CBX4 COPS5 G6PD CLDN1

2.69e-04301314DOID:684 (is_marker_for)
Diseasecolon adenocarcinoma (is_implicated_in)

UBR5 STAT1

3.42e-0426312DOID:234 (is_implicated_in)
Diseasemacular degeneration (is_marker_for)

CDKN1B ELN

3.42e-0426312DOID:4448 (is_marker_for)
Diseasenephroblastoma (is_marker_for)

CDKN1B STAT1

5.87e-0434312DOID:2154 (is_marker_for)
Diseaseliver cirrhosis (biomarker_via_orthology)

ELN CLDN1

5.87e-0434312DOID:5082 (biomarker_via_orthology)
Diseasecataract (implicated_via_orthology)

CDKN1B G6PD

7.33e-0438312DOID:83 (implicated_via_orthology)
Diseasecervix uteri carcinoma in situ (is_marker_for)

CDKN1B CD46

8.96e-0442312DOID:8991 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
FRTYPKGYKPPDEGP

COPS5

186

Q92905
PPPYGKRAPSPGAYK

ATN1

636

P54259
PGAYKTATPPGYKPG

ATN1

646

P54259
SLGKEYYAPAPLPPG

CEP78

371

Q5JTW2
YLREPKYYPGGPPTP

AHDC1

21

Q5TGY3
EFYYRPPRPPKGACK

CDKN1B

86

P46527
TYNEPFPYIDPKKGP

C2orf73

61

Q8N5S3
YAFKPPPRPDFGTSG

AGO2

21

Q9UKV8
GKPAYYPFPQRKTPR

C9orf152

211

Q5JTZ5
KPKPIPYIYGSRGPT

G6PD

476

P11413
PGPKYKLPPNTGYAL

ODF3B

26

A8MYP8
SKPFPRYGYKPSPPN

PLA2G12A

71

Q9BZM1
YYGTPKPPSQPVSGK

MAGI1

186

Q96QZ7
YKPPVSNYPGYPKPE

CD46

321

P15529
GPGPVAGPKLYPKLY

FGFRL1

461

Q8N441
YFKPPFGPYPEKSGK

LRGUK

721

Q96M69
PGPGDYFPEKSTKYV

ODF3

101

Q96PU9
PAKSRGGPGPDYYLK

HPSE2

131

Q8WWQ2
QPPPSYKPLFLDRGY

PRR7

196

Q8TB68
KKVYYPADPPPYIDG

CAPN7

616

Q9Y6W3
PRPYPKPAPSSGKDY

CLDN1

196

O95832
PPPPGKSGKYYYQLN

CBX4

141

O00257
KPLGRPYPPYSLADF

GLMP

141

Q8WWB7
YPIKAPKLPGGYGLP

ELN

206

P15502
PPNYGKYCVRPKKPA

C4orf51

136

C9J302
PRFPKYTGLAPLYPK

PCARE

766

A6NGG8
KLPGEYFRYKGVPFP

SULT2B1

26

O00204
AFGKYYSRPKEAPEP

STAT1

676

P42224
YFKGEFPPYPKPGEI

SGCE

66

O43556
FPPGITYKPGDNYPV

SOX6

291

P35712
YYPSNKPGVEPKRPC

PIAS4

226

Q8N2W9
LYPYPPEMGKPATGD

TNS2

651

Q63HR2
YQPGKRGFYTPRPGK

UBR5

2506

O95071
NGPYKGPVYEKPFDF

ZNF670

166

Q9BS34
PPSYDIKFGGPSPQY

USP54

621

Q70EL1
PGYAEPLKGVPPEKF

MYOZ3

141

Q8TDC0