Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenoincreased salivary adenocarcinoma incidence

GON4L YY1AP1

9.24e-062432MP:0000621
Domain-

ATP8B4 ATP7A PMM2

7.52e-04645233.40.50.1000
DomainHAD-like_dom

ATP8B4 ATP7A PMM2

1.39e-0379523IPR023214
Domain-

ATP8B4 ATP7A

3.57e-03325223.40.1110.10
Domain-

ATP8B4 ATP7A

3.57e-03325222.70.150.10
DomainATPase_P-typ_cyto_domN

ATP8B4 ATP7A

4.27e-0335522IPR023299
DomainP_typ_ATPase

ATP8B4 ATP7A

4.51e-0336522IPR001757
DomainATPase_P-typ_P_site

ATP8B4 ATP7A

4.51e-0336522IPR018303
DomainATPASE_E1_E2

ATP8B4 ATP7A

4.51e-0336522PS00154
DomainATPase_P-typ_transduc_dom_A

ATP8B4 ATP7A

4.76e-0337522IPR008250
DomainE1-E2_ATPase

ATP8B4 ATP7A

4.76e-0337522PF00122
Pubmed

Combinatorial CRISPR screen identifies fitness effects of gene paralogues.

ALKBH4 LIMK2 ELL2 ARFGEF1 PPA1 IDE

4.50e-0718654633637726
Pubmed

The transcriptional regulator GON4L is required for viability and hematopoiesis in mice.

GON4L YY1AP1

2.37e-06254233864850
Pubmed

The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis.

GON4L YY1AP1

2.37e-06254220530203
Pubmed

Newly identified Gon4l/Udu-interacting proteins implicate novel functions.

GON4L YY1AP1

2.37e-06254232848183
Pubmed

Early B Cell Progenitors Deficient for GON4L Fail To Differentiate Due to a Block in Mitotic Cell Division.

GON4L YY1AP1

7.09e-06354228381640
Pubmed

The Justy mutant mouse strain produces a spontaneous murine model of salivary gland cancer with myoepithelial and basal cell differentiation.

GON4L YY1AP1

7.09e-06354223608756
Pubmed

The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression.

GON4L YY1AP1

2.36e-05554221454521
Pubmed

Ipsilateral and Contralateral Retinal Ganglion Cells Express Distinct Genes during Decussation at the Optic Chiasm.

ZIC2 SEMA3E

3.56e-041854227957530
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

INTU MTMR12 GON4L YY1AP1 VAT1L

4.23e-0440754512693553
Pubmed

VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm.

ZIC2 SEMA3E

4.42e-042054221658587
Pubmed

Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

GON4L ZDBF2 VAT1L

5.29e-0410154310997877
Pubmed

Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction.

HTR2B CFB SEMA3E

5.93e-0410554324667918
Pubmed

Tissue-specific activities of the Fat1 cadherin cooperate to control neuromuscular morphogenesis.

FAT1 SEMA3E

6.94e-042554229768404
Pubmed

The LIFEdb database in 2006.

LIMK2 AHI1 CLIC2 ECM2 YY1AP1 CDC42EP3

8.56e-0472054616381901
Pubmed

From ORFeome to biology: a functional genomics pipeline.

LIMK2 AHI1 CLIC2 ECM2 YY1AP1 CDC42EP3

8.68e-0472254615489336
Pubmed

Alternatively spliced isoforms of WT1 control podocyte-specific gene expression.

THSD7A SEMA3E

8.72e-042854225993318
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

CAD SBNO1 CDC16 BRD3 PPA1 POLR3A PHC2

9.41e-04101454732416067
Pubmed

Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

LIMK2 AHI1 ECM2 GON4L YY1AP1 CDC42EP3

1.06e-0375054611230166
Pubmed

Proteomic analysis of the NOS2 interactome in human airway epithelial cells.

FAT1 CAD AKR1B10

1.31e-0313854323438482
Pubmed

DNA cloning using in vitro site-specific recombination.

LIMK2 AHI1 CLIC2 ECM2 YY1AP1 CDC42EP3

1.41e-0379454611076863
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

CAD ATP8B4 SBNO1 CDC16 PPA1 IDE HARS1 POLR3A

1.51e-03142554830948266
Pubmed

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.

AHI1 PMM2

1.52e-033754226951610
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_5|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ATP8B4 HTR2B CLIC2 GRIN1 PPA1

1.66e-061645454b10b78d4d76023c3c5bcd427757218fdd5465ca
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.3|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LIF LIMK2 THSD7A CFB PMM2

1.81e-061675458fede587572d465cb63f7828141a574185bbb819
ToppCelldroplet-Lung-LUNG-30m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HTR2B THSD7A ECM2 MROH2A FAM217A

3.07e-06186545f23f21781a758541f59c06efa7739d26a03fb478
ToppCelldroplet-Lung-LUNG-30m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HTR2B THSD7A ECM2 MROH2A FAM217A

3.07e-061865450de87109da9324c597fadf2eb782f0f158afe832
ToppCellfacs-Lung-nan-3m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MTMR12 HTR2B THSD7A ECM2 FAM217A

3.49e-0619154548823a97c38263f2c6e58348214f5b62773a6368
ToppCellfacs-Lung-nan-3m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MTMR12 HTR2B THSD7A ECM2 FAM217A

3.49e-061915450eedc66e967b1837ce2c14f8c14b3c1eba868c76
ToppCellCerebellum|World / BrainAtlas - Mouse McCarroll V32

ACADVL DRAP1 ZIC2 MYBPC3

3.05e-05147544dd730224e39571ca2c35042e242a908a02ee377d
ToppCellClub_cells-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

THSD7A DLX3 VAT1L SEMA3E

4.24e-05160544b261a3a49c850d92bc9e04fc3527c752dfe37a1a
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-NK/T|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF831 FAM217A CDC42EP3 SEMA3E

4.35e-05161544140b3c7077947c541cff54f6754e2df968345f4d
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-NK_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF831 FAM217A CDC42EP3 SEMA3E

4.45e-0516254416f9fbcaa0093ffc5a2a5e32db6040e2cb519d47
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_5|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ATP8B4 HTR2B CLIC2 PPA1

4.67e-051645443a4ecc632be003d09b765c992804134348d2278b
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HTR2B THSD7A VAT1L FAM217A

5.25e-0516954458136b8a0bf2dab45c91a053ef7225ea49ccb871
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HTR2B THSD7A VAT1L FAM217A

5.25e-0516954404c6ed38e1d1befba5ef5f37a3c1e045a0b163d6
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-like-AT1_Progenitor|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

INTU EML3 POLR3A SEMA3E

6.28e-05177544164ffbbf798defa3728197deb1a14b661490e525
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-LTi-like_NCR+_ILC3|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LIF ZNF492 ATP8B4 CASC2

6.42e-051785440b59e3d75b143bd7bf91a7800a49699c51e68c5a
ToppCellCOPD-Myeloid-Mast|World / Disease state, Lineage and Cell class

LIF ATP8B4 ELL2 CDC42EP3

7.00e-0518254468a1e7b804f309bfd6c23d65fad20a9a962712ae
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALKBH4 HTR2B THSD7A FAM217A

7.15e-05183544919c9861073d12fd12aecd7469b1478b13838c43
ToppCellTCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Epithelioid_Cell-4|TCGA-Uvea / Sample_Type by Project: Shred V9

HTR2B CLIC2 ARFGEF1 IDE

7.30e-051845449c56753e5e668be888662e4713cf4ce44e6c58fb
ToppCellCOVID-19-kidney-FLT1+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

MTMR12 LIMK2 ELL2 PHC2

7.45e-05185544673308ca0514a4d3629d61fe91e9d8fb31b72166
ToppCellCOPD-Myeloid-Mast|COPD / Disease state, Lineage and Cell class

LIF ATP8B4 ELL2 CDC42EP3

7.61e-05186544def6f0f284acc2154738574c8c5d3d2a5ef1f208
ToppCellfacs-Lung-3m-Endothelial-lymphatic_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MTMR12 HTR2B THSD7A FAM217A

8.26e-05190544a1514d2186eb4fe569971ab22dc0c17d353fb94a
ToppCellfacs-Lung-3m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MTMR12 HTR2B THSD7A FAM217A

8.26e-051905440bb954a94317cfc742b9b6221bb80f8baa6d3ff1
ToppCellfacs-Lung-3m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MTMR12 HTR2B THSD7A FAM217A

8.26e-0519054426e2237f65cb43723c5da853831b40df2982d6e4
ToppCelldroplet-Lung-30m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HTR2B THSD7A ECM2 FAM217A

8.43e-0519154451cff0594ac7ad8c065c8ea2301f8c149bd062b4
ToppCelldroplet-Lung-30m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HTR2B THSD7A ECM2 FAM217A

8.43e-05191544a55b6f0a7ec1a8852ffca593cfdccd7edea09b7b
ToppCelldroplet-Lung-30m-Endothelial-lymphatic_endothelial|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HTR2B THSD7A ECM2 FAM217A

8.43e-0519154438681a1b182d6af5cce85db5431b6eba4b20ad96
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LIF FAT1 ARFGEF1 ZNF98

8.60e-051925442510f22197502f60fd266b7f42eff040f25b8ae7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LIF FAT1 ARFGEF1 ZNF98

8.60e-05192544e8e316f396834bcd34843e56e1d86f310fd6aada
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

FAT1 THSD7A VAT1L SEMA3E

9.13e-05195544dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Intermediate|10w / Sample Type, Dataset, Time_group, and Cell type.

ATP8B4 VAT1L POLR3A ZIC2

1.01e-04200544e5a8647c47a49c8c90c78d681193946de103d8ff
Diseasesalivary gland cancer (implicated_via_orthology)

GON4L YY1AP1

3.05e-062522DOID:8850 (implicated_via_orthology)
Diseaseschizophrenia (implicated_via_orthology)

SBNO1 GRIN1 ZIC2

2.39e-0468523DOID:5419 (implicated_via_orthology)
DiseaseCardiac Hypertrophy

LIF HTR2B MYBPC3

4.14e-0482523C1383860
DiseaseCardiomegaly

LIF HTR2B MYBPC3

4.14e-0482523C0018800

Protein segments in the cluster

PeptideGeneStartEntry
KQDYGPKVNFRKQKL

ALKBH4

106

Q9NXW9
KKAYLVKNKPPQRLT

HTR2B

246

P41595
RYVKSCLQKKQRKPF

BRD3

631

Q15059
LKAYKKPELLARLQK

ELL2

216

O00472
IYKQGRKLFPIKLKN

TBC1D32

441

Q96NH3
RKIRKKLKEQLTYFP

AHI1

206

Q8N157
IDLFNKKPKRGIQYL

ARFGEF1

706

Q9Y6D6
KNARKKYPKLNGLLA

CDKL3

246

Q8IVW4
QIEKLLNKPGLKYKP

AKR1B10

166

O60218
YKPGQLNLLFNKRKF

ATP8B4

941

Q8TF62
NKPAALQALKRKKRY

CHMP4BP1

21

P59074
PIYLKAANNKKGKKF

CDC42EP3

6

Q9UKI2
RSKFKKLYKNGEVPL

DLX3

181

O60479
AFVKKQPKYLKLGAI

ATP7A

236

Q04656
KKYNARFPPARIKKI

DRAP1

6

Q14919
KLKNKLKYGQTIRPI

CFB

581

P00751
NKPQFLQKFYKIRLP

FAT1

1241

Q14517
KYLDLGKNQIKKIPA

LRRD1

536

A4D1F6
KTLFGQLKKYPEKLI

MTMR12

126

Q9C0I1
PNVLKFIGVLYKDKK

LIMK2

386

P53671
KKLGCQLLGKYKQII

LIF

181

P15018
DRTPYQLVKKLQKKI

FAM13B

566

Q9NYF5
KRKKQIRIQYKPSLF

MGAT4D

341

A6NG13
KYEPKLKQFTKILRR

INTU

106

Q9ULD6
LRFLFENKLKKYNKP

CDC16

201

Q13042
YYKLNIIKKEPGQKL

ETV7

286

Q9Y603
IKFYKKTKQLPVLGK

GON4L

881

Q3T8J9
QLKGKLRKFFKEPYS

CASC2

61

Q8IU53
KPLKSLAYLRLGKNK

ECM2

461

O94769
LNPIKQDVKKGKLRY

PPA1

66

Q15181
VKGYNDKQPILLKKI

IDE

631

P14735
LTRKQGVFGKYKKPK

EML3

446

Q32P44
APKRNFGTKKKLYRQ

FAM217A

461

Q8IXS0
PKKKLFLVYRPNTGK

SBNO1

1226

A3KN83
IKAELLYKKNPKLLN

HARS1

436

P12081
LLPKLNIIKVAAKKY

CLIC2

186

O15247
LGAPKKVKQYRKVLL

MROH2A

1416

A6NES4
YIAKIKLPKKRGTFI

PMM2

106

O15305
IYLACKKPKKPQRRQ

THSD7A

1626

Q9UPZ6
RPGLTYLQKRGLKKK

POLR3A

131

O14802
LFGTKAQKEKYLPKL

ACADVL

191

P49748
NLKKKYAQGFLPEKL

PHC2

596

Q8IXK0
KIYNVCPRKGKKIFI

ZNF322

16

Q6U7Q0
NKLGFPKKVYKPIIL

ZDBF2

2186

Q9HCK1
EKLIGLYNQKKIKPV

VAT1L

336

Q9HCJ6
PKKNILLTIGSYKNK

CAD

1311

P27708
NIIKFYKKTKQLPVL

YY1AP1

336

Q9H869
KQGKKNYFQKVILRR

ZNF492

56

Q9P255
PKQGKKNYFQKVILR

ZNF98

96

A6NK75
KPILVKTDGKYNLKQ

SEMA3E

421

O15041
SKQRKLKINPKRYKG

ZNF831

1281

Q5JPB2
GKPFKAKYKLVNHIR

ZIC2

311

O95409
QPILGYILERKKKKS

MYBPC3

801

Q14896
KPFKYQGLTILVKKE

GRIN1

531

Q05586