Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR10H3 OR5AU1 OR1Q1 OR10J6P OR7D2 OR51I2 OR2G2 OR2Y1 OR1E3 OR1F12P OR2W5P	6.61e-08	431	61	11	GO:0004984
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	GABRE OR10H3 OR5AU1 OR1Q1 OR10J6P OR7D2 OR51I2 OR2G2 OR2Y1 OR1E3 OR1F12P OR2W5P ADGRA2 PLXNB3 GABRA3	9.81e-06	1353	61	15	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR10H3 OR5AU1 OR1Q1 OR10J6P OR7D2 OR51I2 OR2G2 OR2Y1 OR1E3 OR1F12P OR2W5P ADGRA2	1.24e-05	884	61	12	GO:0004930
GeneOntologyMolecularFunction	inositol 1,4,5-trisphosphate-gated calcium channel activity	ITPR1 ITPR2	2.75e-05	3	61	2	GO:0005220
GeneOntologyMolecularFunction	benzodiazepine receptor activity	GABRE GABRA3	4.96e-04	11	61	2	GO:0008503
GeneOntologyMolecularFunction	inositol 1,4,5 trisphosphate binding	ITPR1 ITPR2	8.16e-04	14	61	2	GO:0070679
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR10H3 OR5AU1 OR1Q1 OR10J6P OR7D2 OR51I2 OR2G2 OR2Y1 OR1E3 OR1F12P OR2W5P	4.08e-08	432	60	11	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR10H3 OR5AU1 OR1Q1 OR10J6P OR7D2 OR51I2 OR2G2 OR2Y1 OR1E3 OR1F12P OR2W5P	8.61e-08	465	60	11	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR10H3 OR5AU1 OR1Q1 OR10J6P OR7D2 OR51I2 OR2G2 OR2Y1 OR1E3 OR1F12P OR2W5P	1.32e-07	485	60	11	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR10H3 OR5AU1 OR1Q1 OR10J6P OR7D2 OR51I2 OR2G2 OR2Y1 OR1E3 OR1F12P OR2W5P	2.85e-07	524	60	11	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR10H3 OR5AU1 OR1Q1 OR10J6P OR7D2 OR51I2 OR2G2 OR2Y1 OR1E3 OR1F12P OR2W5P	4.36e-07	547	60	11	GO:0007606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR10H3 OR5AU1 OR1Q1 OR10J6P OR7D2 OR51I2 OR2G2 OR2Y1 OR1E3 OR1F12P OR2W5P	8.04e-07	582	60	11	GO:0050906
GeneOntologyBiologicalProcess	detection of stimulus	OR10H3 OR5AU1 OR1Q1 OR10J6P OR7D2 OR51I2 OR2G2 OR2Y1 OR1E3 OR1F12P OR2W5P	6.42e-06	722	60	11	GO:0051606
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR10H3 OR5AU1 OR1Q1 OR10J6P OR7D2 OR51I2 OR2G2 OR2Y1 OR1E3 OR1F12P OR2W5P NCSTN ADGRA2 ITPR1	3.58e-05	1395	60	14	GO:0007186
GeneOntologyBiologicalProcess	sensory perception	CRYGS OR10H3 OR5AU1 OR1Q1 OR10J6P OR7D2 OR51I2 OR2G2 OR2Y1 OR1E3 OR1F12P OR2W5P	5.05e-05	1072	60	12	GO:0007600
Domain	MIR	POMT1 ITPR1 ITPR2	3.54e-06	10	59	3	PS50919
Domain	MIR	POMT1 ITPR1 ITPR2	3.54e-06	10	59	3	PF02815
Domain	MIR	POMT1 ITPR1 ITPR2	3.54e-06	10	59	3	SM00472
Domain	MIR_motif	POMT1 ITPR1 ITPR2	3.54e-06	10	59	3	IPR016093
Domain	Olfact_rcpt	OR10H3 OR5AU1 OR1Q1 OR7D2 OR51I2 OR2G2 OR2Y1 OR1F12P OR2W5P	3.66e-06	393	59	9	IPR000725
Domain	InsP3_rcpt-bd	ITPR1 ITPR2	2.94e-05	3	59	2	IPR000493
Domain	RIH_assoc	ITPR1 ITPR2	1.46e-04	6	59	2	PF08454
Domain	RIH_assoc-dom	ITPR1 ITPR2	1.46e-04	6	59	2	IPR013662
Domain	RIH_dom	ITPR1 ITPR2	1.46e-04	6	59	2	IPR000699
Domain	Ins145_P3_rcpt	ITPR1 ITPR2	1.46e-04	6	59	2	IPR014821
Domain	Ryanodine_recept-rel	ITPR1 ITPR2	1.46e-04	6	59	2	IPR015925
Domain	-	ITPR1 ITPR2	1.46e-04	6	59	2	1.25.10.30
Domain	RYDR_ITPR	ITPR1 ITPR2	1.46e-04	6	59	2	PF01365
Domain	Ins145_P3_rec	ITPR1 ITPR2	1.46e-04	6	59	2	PF08709
Domain	7tm_1	OR10H3 OR5AU1 OR1Q1 OR7D2 OR51I2 OR2G2 OR2Y1 OR1F12P OR2W5P	2.54e-04	677	59	9	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR10H3 OR5AU1 OR1Q1 OR7D2 OR51I2 OR2G2 OR2Y1 OR1F12P OR2W5P	2.77e-04	685	59	9	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR10H3 OR5AU1 OR1Q1 OR7D2 OR51I2 OR2G2 OR2Y1 OR1F12P OR2W5P	2.96e-04	691	59	9	PS50262
Domain	GPCR_Rhodpsn	OR10H3 OR5AU1 OR1Q1 OR7D2 OR51I2 OR2G2 OR2Y1 OR1F12P OR2W5P	2.99e-04	692	59	9	IPR000276
Domain	ARM-type_fold	RALGAPA1 INTS1 DAAM1 TBCD ITPR1 ITPR2	6.86e-04	339	59	6	IPR016024
Domain	GPCR_Rhodpsn_7TM	OR10H3 OR5AU1 OR1Q1 OR7D2 OR51I2 OR2G2 OR2Y1 OR2W5P	1.16e-03	670	59	8	IPR017452
Domain	GABAA/Glycine_rcpt	GABRE GABRA3	2.38e-03	23	59	2	IPR006028
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR10H3 OR5AU1 OR1Q1 OR7D2 OR51I2 OR2G2 OR2Y1 OR1E3 OR1F12P	2.98e-06	417	42	9	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR10H3 OR5AU1 OR1Q1 OR7D2 OR51I2 OR2G2 OR2Y1 OR1E3 OR1F12P	8.56e-05	636	42	9	M41834
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY	ITPR1 ITPR2	8.62e-05	5	42	2	M49000
Pathway	KEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2	1.29e-04	6	42	2	M47960
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR10H3 OR5AU1 OR1Q1 OR7D2 OR51I2 OR2G2 OR2Y1	1.35e-04	389	42	7	M14091
Pathway	KEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2	3.08e-04	9	42	2	M47852
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR2	3.84e-04	10	42	2	M47661
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR2	4.69e-04	11	42	2	M49033
Pathway	REACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION	ITPR1 ITPR2	4.69e-04	11	42	2	M27466
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	6.62e-04	13	42	2	M47696
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	6.62e-04	13	42	2	M47751
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR2	6.62e-04	13	42	2	M47656
Pathway	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	ITPR1 ITPR2	6.62e-04	13	42	2	MM14553
Pathway	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	ITPR1 ITPR2	1.01e-03	16	42	2	M26945
Pathway	KEGG_LONG_TERM_POTENTIATION	CREBBP ITPR1 ITPR2	1.17e-03	70	42	3	M3115
Pathway	WP_GPCRS_ODORANT	OR10H3 OR2Y1 OR1E3 ADGRA2	1.19e-03	157	42	4	MM15872
Pathway	WP_ALZHEIMERS_DISEASE	NCSTN ITPR1 ITPR2	1.38e-03	74	42	3	MM15962
Pathway	REACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION	ITPR1 ITPR2	1.43e-03	19	42	2	M27423
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	1.43e-03	19	42	2	M47760
Pathway	KEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR2	1.43e-03	19	42	2	M47733
Pathway	KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	PIKFYVE ITPR1 ITPR2	1.49e-03	76	42	3	M9052
Pathway	KEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	1.59e-03	20	42	2	M47688
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	1.76e-03	21	42	2	M47689
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	1.93e-03	22	42	2	M47690
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	1.93e-03	22	42	2	M47675
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR2	2.11e-03	23	42	2	M47676
Pubmed	The human olfactory receptor gene family.	OR10H3 OR5AU1 OR1Q1 OR10J6P OR7D2 OR51I2 OR2G2 OR2Y1 OR1E3 OR1F12P	3.98e-08	541	62	10	14983052
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR10H3 OR5AU1 OR1Q1 OR51I2 OR2Y1 OR1E3 OR1F12P	2.49e-06	340	62	7	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR10H3 OR5AU1 OR1Q1 OR51I2 OR2Y1 OR1E3 OR1F12P	2.49e-06	340	62	7	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR10H3 OR5AU1 OR1Q1 OR51I2 OR2Y1 OR1E3 OR1F12P	2.64e-06	343	62	7	32295537
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR5AU1 OR1Q1 OR10J6P OR7D2 OR2Y1 OR2W5P	2.67e-06	219	62	6	12213199
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR10H3 OR5AU1 OR1Q1 OR51I2 OR2Y1 OR1E3 OR1F12P	2.79e-06	346	62	7	14611657
Pubmed	Type 1 and 2 IP3 receptors respond differently to catecholamines and stress.	ITPR1 ITPR2	3.13e-06	2	62	2	19120126
Pubmed	An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown.	ITPR1 ITPR2	3.13e-06	2	62	2	18708078
Pubmed	Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice.	ITPR1 ITPR2	3.13e-06	2	62	2	15201137
Pubmed	Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2.	ITPR1 ITPR2	3.13e-06	2	62	2	23582047
Pubmed	Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.	ITPR1 ITPR2	9.37e-06	3	62	2	31979185
Pubmed	Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.	ITPR1 ITPR2	9.37e-06	3	62	2	10874040
Pubmed	Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.	ITPR1 ITPR2	9.37e-06	3	62	2	9808793
Pubmed	Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.	ITPR1 ITPR2	9.37e-06	3	62	2	24904548
Pubmed	Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.	ITPR1 ITPR2	9.37e-06	3	62	2	20395455
Pubmed	Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	9.37e-06	3	62	2	17327232
Pubmed	Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.	ITPR1 ITPR2	9.37e-06	3	62	2	17437169
Pubmed	Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.	ITPR1 ITPR2	9.37e-06	3	62	2	23223241
Pubmed	Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.	ITPR1 ITPR2	9.37e-06	3	62	2	16014380
Pubmed	Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.	ITPR1 ITPR2	9.37e-06	3	62	2	18194433
Pubmed	Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.	ITPR1 ITPR2	9.37e-06	3	62	2	17890015
Pubmed	Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.	ITPR1 ITPR2	9.37e-06	3	62	2	18547250
Pubmed	Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.	ITPR1 ITPR2	9.37e-06	3	62	2	36350267
Pubmed	Inositol 1,4,5-trisphosphate receptors are essential for fetal-maternal connection and embryo viability.	ITPR1 ITPR2	9.37e-06	3	62	2	32320395
Pubmed	IP3 receptors regulate vascular smooth muscle contractility and hypertension.	ITPR1 ITPR2	9.37e-06	3	62	2	27777977
Pubmed	The versatility and universality of calcium signalling.	ITPR1 ITPR2	9.37e-06	3	62	2	11413485
Pubmed	Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.	ITPR1 ITPR2	9.37e-06	3	62	2	23983250
Pubmed	Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.	ITPR1 ITPR2	9.37e-06	3	62	2	9858485
Pubmed	Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	9.37e-06	3	62	2	26009177
Pubmed	Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.	ITPR1 ITPR2	9.37e-06	3	62	2	17581770
Pubmed	Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.	ITPR1 ITPR2	9.37e-06	3	62	2	20427533
Pubmed	Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.	ITPR1 ITPR2	9.37e-06	3	62	2	18241669
Pubmed	Receptor-activated single channels in intact human platelets.	ITPR1 ITPR2	9.37e-06	3	62	2	1693919
Pubmed	Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.	ITPR1 ITPR2	9.37e-06	3	62	2	19068129
Pubmed	Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.	ITPR1 ITPR2	9.37e-06	3	62	2	23955339
Pubmed	Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.	ITPR1 ITPR2	1.87e-05	4	62	2	25215520
Pubmed	CBP-mediated Wnt3a/β-catenin signaling promotes cervical oncogenesis initiated by Piwil2.	PIWIL2 CREBBP	1.87e-05	4	62	2	33190089
Pubmed	Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.	ITPR1 ITPR2	1.87e-05	4	62	2	21424589
Pubmed	IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.	ITPR1 ITPR2	1.87e-05	4	62	2	28419336
Pubmed	Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.	ITPR1 ITPR2	1.87e-05	4	62	2	21818117
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	ITPR1 ITPR2	1.87e-05	4	62	2	19120137
Pubmed	Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	1.87e-05	4	62	2	11163362
Pubmed	IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.	ITPR1 ITPR2	1.87e-05	4	62	2	35494252
Pubmed	Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.	ITPR1 ITPR2	1.87e-05	4	62	2	28615414
Pubmed	Impact of epsilon and theta subunits on pharmacological properties of alpha3beta1 GABAA receptors expressed in Xenopus oocytes.	GABRE GABRA3	1.87e-05	4	62	2	16412217
Pubmed	Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.	ITPR1 ITPR2	1.87e-05	4	62	2	10828023
Pubmed	The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity.	DROSHA SUN1	3.12e-05	5	62	2	31686651
Pubmed	BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor.	ITPR1 ITPR2	3.12e-05	5	62	2	11782428
Pubmed	InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.	ITPR1 ITPR2	3.12e-05	5	62	2	21568942
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RALGAPA1 WASHC4 FLYWCH1 SUN1 NCSTN DAAM1 ADGRA2	4.32e-05	529	62	7	14621295
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	PIKFYVE RALGAPA1 KNTC1 PALD1 SUN1 WRNIP1 BRAP ITPR2	4.64e-05	733	62	8	34672954
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	ITPR1 ITPR2	4.67e-05	6	62	2	23463619
Pubmed	Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.	ITPR1 ITPR2	4.67e-05	6	62	2	21762810
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	ITPR1 ITPR2	4.67e-05	6	62	2	16844763
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	ITPR1 ITPR2	4.67e-05	6	62	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	ITPR1 ITPR2	4.67e-05	6	62	2	25966694
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	ITPR1 ITPR2	6.53e-05	7	62	2	11860456
Pubmed	Genetic dissection of gustatory sensitivity to bitterness (sucrose octaacetate) in mice.	OR2Y1 ITPR1	6.53e-05	7	62	2	10609087
Pubmed	Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.	ITPR1 ITPR2	6.53e-05	7	62	2	22495310
Pubmed	Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation.	GABRE GABRA3	8.69e-05	8	62	2	18185516
Pubmed	Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes.	DROSHA GEMIN4	8.69e-05	8	62	2	20211803
Pubmed	Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.	ITPR1 ITPR2	1.12e-04	9	62	2	25737585
Pubmed	Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study.	DROSHA GEMIN4	1.39e-04	10	62	2	20721975
Pubmed	Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development.	ITPR1 ITPR2	1.70e-04	11	62	2	27514653
Pubmed	Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis.	ITPR1 ITPR2	1.70e-04	11	62	2	20824138
Pubmed	Evolution of odorant receptors expressed in mammalian testes.	OR2Y1 OR1E3	2.41e-04	13	62	2	11014824
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ONECUT2 WASHC4 FLYWCH1 SUN1 INTS1 GEMIN4 NCSTN MTCH1 TBCD	2.68e-04	1203	62	9	29180619
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	PIKFYVE RALGAPA1 WASHC4 SUN1 ITPR1 ITPR2	2.78e-04	504	62	6	34432599
Pubmed	Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan.	DROSHA GEMIN4	2.81e-04	14	62	2	20585341
Pubmed	Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers.	ITPR1 ITPR2	2.81e-04	14	62	2	34630045
Pubmed	Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb.	OR2Y1 OR1E3	2.81e-04	14	62	2	7528109
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR5AU1 OR2Y1 OR1E3	3.20e-04	74	62	3	15081110
Pubmed	Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.	ITPR1 ITPR2	3.23e-04	15	62	2	28578927
Pubmed	The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing.	PIWIL2 TNP2	3.23e-04	15	62	2	25762440
Pubmed	The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation.	PIWIL2 TNP2	4.18e-04	17	62	2	23401851
Pubmed	Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.	GABRE GABRA3	4.70e-04	18	62	2	19078961
Pubmed	Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.	DROSHA GEMIN4	4.70e-04	18	62	2	19047128
Pubmed	Regulation of the endosomal SNX27-retromer by OTULIN.	WRNIP1 BRAP	6.42e-04	21	62	2	31541095
Pubmed	Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.	CFLAR LIG4 TNFSF18	6.64e-04	95	62	3	20568250
Pubmed	HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure.	CREBBP ITPR2	7.06e-04	22	62	2	31286141
Pubmed	The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity.	ITPR1 ITPR2	7.06e-04	22	62	2	11696558
Pubmed	mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells.	INTS1 WRNIP1 BRAP	7.27e-04	98	62	3	34943047
Pubmed	Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.	OR1Q1 OR1E3	8.41e-04	24	62	2	9119360
Pubmed	Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma.	DROSHA GEMIN4	8.41e-04	24	62	2	20732906
Pubmed	Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.	ITPR1 ITPR2	8.41e-04	24	62	2	10843712
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	INTS1 TBCD ITPR1	8.64e-04	104	62	3	31240132
Pubmed	Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk.	DROSHA GEMIN4	9.14e-04	25	62	2	19138993
Pubmed	Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.	LIG4 GEMIN4	9.14e-04	25	62	2	15385968
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	DROSHA INTS1 WRNIP1 GEMIN4	9.30e-04	242	62	4	34011540
Pubmed	Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.	OR5AU1 OR2Y1	1.07e-03	27	62	2	32061665
Pubmed	Conditionals by inversion provide a universal method for the generation of conditional alleles.	DROSHA ADGRA2	1.07e-03	27	62	2	23918385
Pubmed	Defining the membrane proteome of NK cells.	INTS1 WRNIP1 GEMIN4 PAM NCSTN DAAM1 ITPR1 ITPR2	1.07e-03	1168	62	8	19946888
Pubmed	Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation.	ITPR1 ITPR2	1.23e-03	29	62	2	32123907
Pubmed	Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.	PALD1 WRNIP1 DAAM1 CREBBP	1.65e-03	283	62	4	21903422
Pubmed	Potential protein partners for the N-terminal domain of human topoisomerase I revealed by phage display.	LIG4 GEMIN4	1.69e-03	34	62	2	12549820
Interaction	GPR17 interactions	KNTC1 WASHC4 INTS1 GEMIN4 TMEM164 MSTO1 TBCD ITPR2	7.02e-07	283	53	8	int:GPR17
Cytoband	7p22.3	SUN1 INTS1	9.79e-04	34	62	2	7p22.3
Cytoband	6p21.2	PI16 MTCH1	1.10e-03	36	62	2	6p21.2
Cytoband	Xq28	GABRE PLXNB3 GABRA3	1.77e-03	176	62	3	Xq28
Cytoband	1q22	PAQR6 MSTO1	2.73e-03	57	62	2	1q22
Cytoband	Ensembl 112 genes in cytogenetic band chrXq28	GABRE PLXNB3 GABRA3	3.04e-03	213	62	3	chrXq28
Cytoband	Ensembl 112 genes in cytogenetic band chr1q22	PAQR6 MSTO1	4.20e-03	71	62	2	chr1q22
GeneFamily	Inositol 1,4,5-triphosphate receptors\|Protein phosphatase 1 regulatory subunits	ITPR1 ITPR2	1.66e-05	3	43	2	297
GeneFamily	Olfactory receptors, family 1	OR1Q1 OR1E3 OR1F12P	1.16e-04	40	43	3	147
GeneFamily	Gamma-aminobutyric acid type A receptor subunits	GABRE GABRA3	9.21e-04	19	43	2	563
GeneFamily	Olfactory receptors, family 2	OR2G2 OR2Y1 OR2W5P	2.45e-03	113	43	3	149
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ADAMTS12 CRYGS PI16 SERINC2	1.19e-05	104	60	4	424a58b04c8b5108b70f15d8353c8e4b9db1e730
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Mgp_(Mgp)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ADAMTS12 CRYGS PI16 SERINC2	1.19e-05	104	60	4	11d91471b6c4fa6b00a91d9fd4db72ee60d1f801
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Mgp_(Mgp)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ADAMTS12 CRYGS PI16 SERINC2	1.19e-05	104	60	4	9b05ae514437eb0c8b1b23607ae8cbc371ffa85b
Disease	Anoxic Encephalopathy	ITPR1 ITPR2	3.67e-06	2	57	2	C0003132
Disease	Brain Hypoxia	ITPR1 ITPR2	3.67e-06	2	57	2	C1527348
Disease	Anoxia of brain	ITPR1 ITPR2	3.67e-06	2	57	2	C0995195
Disease	Hypoxic Brain Damage	ITPR1 ITPR2	3.67e-06	2	57	2	C1140716
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ITPR1 ITPR2	2.39e-04	12	57	2	DOID:1441 (implicated_via_orthology)
Disease	response to triptolide, cytotoxicity measurement	CFLAR ADGRA2	4.32e-04	16	57	2	EFO_0006952, EFO_0007662
Disease	Muscle hypotonia	RALGAPA1 INTS1	4.89e-04	17	57	2	C0026827
Disease	obesity (implicated_via_orthology)	DNAH10 PLXNB3 ITPR1 ITPR2	8.00e-04	215	57	4	DOID:9970 (implicated_via_orthology)
Disease	Cataract	CRYGS INTS1	2.34e-03	37	57	2	C0086543
Disease	ornithine measurement	OR1Q1 WRNIP1	3.29e-03	44	57	2	EFO_0009776

Protein segments in the cluster

Peptide	Gene	Start	Entry
MHGSCSFLMLLLPLL	PI16	1	Q6UXB8
AMLCILTVPAAMTSH	BRAP	161	Q7Z569
HMLLNLCFHIAMTSA	ADGRA2	806	Q96PE1
MHMAIAAEPRHCLAT	CCNJL	401	Q8IV13
SLPHCRTMKNVLNHM	CREBBP	381	Q92793
VHHMLLFGCNMPSST	PAM	101	P19021
MGRLHLRCPVFMSFL	ASB14	546	A6NK59
LPLHHIRRMFMGDSC	CFLAR	331	O15519
LSHVKMMASSAPLCH	ADAMTS12	126	P58397
ELMLTHVARHGPMCH	PRODH2	416	Q9UF12
NIFPKHHMCLATHLM	IQCH	541	Q86VS3
PFDLRASFCRLMLHM	ITPR2	771	Q14571
PLCAMQLFSHMHAVI	NCSTN	211	Q92542
TMTPMHYHLREIIIC	PALD1	736	Q9ULE6
PLLHTLMMAHLHFCS	OR1F12P	156	Q8NHA8
RPLHYTVLMHIHLCM	OR2G2	131	Q8NGZ5
MCHSRSCHPTMTILQ	IER3	1	P46695
LVMSMHRSHFLACPL	INTS1	1421	Q8N201
SFCRLMLHMHVDRDP	ITPR1	781	Q14643
MVMRSHCHQPDLAGL	FLYWCH1	651	Q4VC44
MCHAAQETPLLHHFM	PLXNB3	1	Q9ULL4
VCRSLHYMAVMRPHL	OR2W5P	126	A6NFC9
HYMAVMRPHLCLQLV	OR2W5P	131	A6NFC9
VCRPLHYMAIMHPHL	OR2Y1	126	Q8NGV0
HSYCLHPDMMRLACA	OR51I2	176	Q9H344
LCSSPVSMVHLADML	MSTO1	346	Q9BUK6
MPAAHMTFLRHRLFL	FAM214B	451	Q7L5A3
PELSIPLHHAMSMSC	ONECUT2	121	O95948
LACLMLMPHSEKRHQ	KNTC1	2076	P50748
YTMRLTIHAECPMHL	GABRA3	181	P34903
SLHMLRFPMDSHSCP	GABRE	196	P78334
AHTFSSMSPRMRHIC	PAQR6	101	Q6TCH4
TICHPLHYNMLMSPR	OR10H3	126	O60404
LHYNMLMSPRGCAHL	OR10H3	131	O60404
LHFSHCAAMGAALLM	POMT1	126	Q9Y6A1
MSILHHCLQMPYKRS	DAAM1	381	Q9Y4D1
SMFCDTPMVHHIRRF	PIKFYVE	1271	Q9Y2I7
RFMIHMCPSTKEHFA	LIG4	741	P49917
PSIMEQFHMREIHSC	CRYGS	116	P22914
MHLHMLCTPLPEEFL	DNAH10	81	Q8IVF4
LDSHLHMPMYLCLSN	OR1E3	51	Q8WZA6
MTIICIDRHLHTPMY	OR10J6P	46	Q8NGY7
ICHPFHYTMILTRML	OR1Q1	126	Q15612
CVSRMLAHPLHVISM	MTCH1	206	Q9NZJ7
LAHPLHVISMRCMVQ	MTCH1	211	Q9NZJ7
VCQHAMMLPVLTHHI	DROSHA	856	Q9NRR4
MMLPVLTHHIRYHQC	DROSHA	861	Q9NRR4
MNSHHSPMRPTILHC	TNP2	86	Q05952
SPDHMQRLTFKLCHM	PIWIL2	916	Q8TC59
MFLLIHVSATLHTPM	OR5AU1	96	Q8NGC0
SLLHISLMMHLIFCK	OR7D2	156	Q96RA2
AAMRAMCIGLRFPHH	ADPRH	131	P54922
HMRLHMGITPFVCRM	ZBTB37	391	Q5TC79
ACNMLHMLVHYVPRL	RALGAPA1	1336	Q6GYQ0
TCHLPRTDAMHMFRD	SLC5A10	241	A0PJK1
NPCHLVTMMHIFLLA	TMEM164	121	Q5U3C3
MCLSHLENMPLSHSR	TNFSF18	1	Q9UNG2
SFHFPLFMTMLHLAV	SLC35C2	41	Q9NQQ7
LMRLPQMTSSLHHLC	TEX11	211	Q8IYF3
RHSAMLLSMDHFTQP	RRN3P2	311	A6NIE6
MMPAAHINSHLDRCL	WRNIP1	26	Q96S55
LMVLHHAAMVLVCFP	TLCD3B	131	Q71RH2
ALRDCVPAMMHARHL	WASHC4	636	Q2M389
LLSMTLSPDLHMRHG	TBCD	606	Q9BTW9
RLSMMIHPAAFTLEH	SUN1	681	O94901
FHFCLVLASLHVMMT	SERINC2	391	Q96SA4
QVFCHALHIMAMLHP	GEMIN4	981	P57678