Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH3 DNAH10 CCDC88C CCDC88A DNAH5

6.34e-07281205GO:0051959
GeneOntologyMolecularFunctionnucleocytoplasmic carrier activity

XPO1 KPNA7 TNPO3 KPNB1

3.92e-05321204GO:0140142
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH3 DNAH10 DNAH5

1.62e-04181203GO:0008569
GeneOntologyMolecularFunctionnuclear import signal receptor activity

KPNA7 TNPO3 KPNB1

2.24e-04201203GO:0061608
GeneOntologyMolecularFunctionphosphatidylinositol kinase activity

PIK3C3 PIK3CA PI4KA

4.97e-04261203GO:0052742
DomainARM-type_fold

CLTCL1 VEPH1 FRYL XPO1 TEX10 PPP2R1A KPNA7 PIK3C3 PIK3CA AOPEP PI4KA VPS35 LTN1 TERB1 STKLD1 TNPO3 KPNB1

4.49e-1133911817IPR016024
DomainARM-like

FRYL XPO1 TEX10 PPP2R1A KPNA7 LTN1 TERB1 STKLD1 TNPO3 KPNB1

8.35e-0627011810IPR011989
DomainPI3Ka

PIK3C3 PIK3CA PI4KA

2.01e-0591183PF00613
DomainPI3Ka

PIK3C3 PIK3CA PI4KA

2.01e-0591183SM00145
Domain-

PIK3C3 PIK3CA PI4KA

2.01e-05911831.25.40.70
DomainPI_Kinase

PIK3C3 PIK3CA PI4KA

2.86e-05101183IPR015433
DomainPInositide-3_kin_accessory_dom

PIK3C3 PIK3CA PI4KA

2.86e-05101183IPR001263
DomainPIK_HELICAL

PIK3C3 PIK3CA PI4KA

2.86e-05101183PS51545
DomainBACK

ENC1 KLHL20 LGALS3BP KLHL3 GMCL1

3.83e-05601185SM00875
DomainCytoplasmic_FMR1-int

CYFIP2 CYFIP1

3.96e-0521182IPR008081
DomainCell_morpho_N

FRYL FRY

3.96e-0521182IPR025614
DomainCell_Morphogen_C

FRYL FRY

3.96e-0521182IPR025481
DomainMOR2-PAG1_mid

FRYL FRY

3.96e-0521182IPR029473
DomainMOR2-PAG1_mid

FRYL FRY

3.96e-0521182PF14228
DomainMOR2-PAG1_C

FRYL FRY

3.96e-0521182PF14225
DomainMOR2-PAG1_N

FRYL FRY

3.96e-0521182PF14222
DomainFragX_IP

CYFIP2 CYFIP1

3.96e-0521182PF05994
DomainBACK

ENC1 KLHL20 LGALS3BP KLHL3 GMCL1

4.15e-05611185IPR011705
DomainBACK

ENC1 KLHL20 LGALS3BP KLHL3 GMCL1

4.15e-05611185PF07707
Domain-

FRYL XPO1 TEX10 PPP2R1A KPNA7 TERB1 TNPO3 KPNB1

8.38e-0522211881.25.10.10
DomainDynein_heavy_chain_D4_dom

DNAH3 DNAH10 DNAH5

8.51e-05141183IPR024317
DomainDynein_HC_stalk

DNAH3 DNAH10 DNAH5

8.51e-05141183IPR024743
DomainDynein_heavy_dom-2

DNAH3 DNAH10 DNAH5

8.51e-05141183IPR013602
DomainDHC_N2

DNAH3 DNAH10 DNAH5

8.51e-05141183PF08393
DomainATPase_dyneun-rel_AAA

DNAH3 DNAH10 DNAH5

8.51e-05141183IPR011704
DomainMT

DNAH3 DNAH10 DNAH5

8.51e-05141183PF12777
DomainAAA_8

DNAH3 DNAH10 DNAH5

8.51e-05141183PF12780
DomainAAA_5

DNAH3 DNAH10 DNAH5

8.51e-05141183PF07728
DomainDHC_fam

DNAH3 DNAH10 DNAH5

1.06e-04151183IPR026983
DomainDynein_heavy

DNAH3 DNAH10 DNAH5

1.06e-04151183PF03028
DomainPI3/4_kinase_CS

PIK3C3 PIK3CA PI4KA

1.06e-04151183IPR018936
DomainDynein_heavy_dom

DNAH3 DNAH10 DNAH5

1.06e-04151183IPR004273
Domain-

PIK3C3 PIK3CA PI4KA

1.30e-041611831.10.1070.11
DomainPI3Kc

PIK3C3 PIK3CA PI4KA

1.30e-04161183SM00146
DomainHEAT_type_2

TEX10 PPP2R1A KPNB1

1.57e-04171183IPR021133
DomainPI3_PI4_kinase

PIK3C3 PIK3CA PI4KA

1.87e-04181183PF00454
DomainPI3_4_KINASE_1

PIK3C3 PIK3CA PI4KA

1.87e-04181183PS00915
DomainPI3_4_KINASE_2

PIK3C3 PIK3CA PI4KA

1.87e-04181183PS00916
DomainPI3/4_kinase_cat_dom

PIK3C3 PIK3CA PI4KA

1.87e-04181183IPR000403
DomainPI3_4_KINASE_3

PIK3C3 PIK3CA PI4KA

1.87e-04181183PS50290
DomainDUF1394

CYFIP2 CYFIP1

2.36e-0441182IPR009828
DomainDUF1394

CYFIP2 CYFIP1

2.36e-0441182PF07159
DomainHEAT

XPO1 TEX10 PPP2R1A KPNB1

4.94e-04581184IPR000357
DomainXpo1

XPO1 TNPO3

5.84e-0461182PF08389
DomainHOOK

CCDC88C CCDC88A

5.84e-0461182PF05622
DomainHook-related_fam

CCDC88C CCDC88A

5.84e-0461182IPR008636
DomainExportin-1/Importin-b-like

XPO1 TNPO3

5.84e-0461182IPR013598
DomainHEAT_REPEAT

XPO1 TEX10 PPP2R1A KPNB1

1.01e-03701184PS50077
DomainDHC_N1

DNAH10 DNAH5

1.08e-0381182PF08385
DomainPI3K_C2

PIK3C3 PIK3CA

1.08e-0381182SM00142
DomainPI3K_C2_dom

PIK3C3 PIK3CA

1.08e-0381182IPR002420
DomainPI3K_C2

PIK3C3 PIK3CA

1.08e-0381182PF00792
DomainPI3K_C2

PIK3C3 PIK3CA

1.08e-0381182PS51547
DomainDynein_heavy_dom-1

DNAH10 DNAH5

1.08e-0381182IPR013594
DomainLDOC1-rel

RTL4 RTL1

2.10e-03111182IPR032567
DomainCadherin_C

PCDHB12 PCDHB11 PCDHGB4

2.36e-03421183IPR032455
DomainCadherin_C_2

PCDHB12 PCDHB11 PCDHGB4

2.36e-03421183PF16492
DomainBTB-kelch_protein

ENC1 KLHL20 KLHL3

2.52e-03431183IPR017096
DomainIMPORTIN_B_NT

XPO1 KPNB1

3.43e-03141182PS50166
DomainHEAT

TEX10 PPP2R1A KPNB1

3.46e-03481183PF02985
DomainBTB

ENC1 KLHL20 LGALS3BP KLHL3 GMCL1

3.49e-031601185PS50097
DomainIBN_N

XPO1 KPNB1

3.94e-03151182PF03810
DomainIBN_N

XPO1 KPNB1

4.48e-03161182SM00913
DomainImportin-beta_N

XPO1 KPNB1

5.06e-03171182IPR001494
DomainPeptidase_aspartic_dom

RTL1 CTSD

5.06e-03171182IPR021109
DomainCadherin_CS

CDH26 PCDHB12 PCDHB11 PCDHGB4

5.06e-031091184IPR020894
DomainCADHERIN_1

CDH26 PCDHB12 PCDHB11 PCDHGB4

5.75e-031131184PS00232
DomainCadherin

CDH26 PCDHB12 PCDHB11 PCDHGB4

5.75e-031131184PF00028
DomainKelch

ENC1 KLHL20 KLHL3

5.89e-03581183SM00612
DomainCADHERIN_2

CDH26 PCDHB12 PCDHB11 PCDHGB4

5.93e-031141184PS50268
Domain-

CDH26 PCDHB12 PCDHB11 PCDHGB4

5.93e-0311411842.60.40.60
DomainCA

CDH26 PCDHB12 PCDHB11 PCDHGB4

6.11e-031151184SM00112
DomainGal_Oxase/kelch_b-propeller

ENC1 KLHL20 KLHL3

6.18e-03591183IPR011043
DomainCadherin-like

CDH26 PCDHB12 PCDHB11 PCDHGB4

6.30e-031161184IPR015919
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH3 DNAH10 DNAH5 DCTN3

2.23e-0527884M47755
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

GAD2 KDM5B TRPM7 TTLL5 ENC1 OBSL1 ABCC5 VPS54 MED13L GMCL1 ATF6 FRY PPP3R1 EHMT2 MAP3K10 EIF3C MORC3 USP33 KPNB1

1.18e-0712851221935914814
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

KDM5B TRPM7 ALS2 TBC1D22B FRYL WNK1 DDX6 CCDC88C CCDC88A PIK3C3 PI4KA MAP3K10 MORC3 TNPO3 BICC1

3.75e-078611221536931259
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

ABR TEX10 CYFIP2 CCDC88C PPP2R1A FRY CYFIP1 CCDC88A EHMT2 PI4KA ELAVL2 SLC4A4 RPA1 UNC13A KPNB1

1.51e-069631221528671696
Pubmed

Gene essentiality and synthetic lethality in haploid human cells.

ECD VPS54 PPP2R1A SCCPDH PIK3CA VPS35 CMTR2 KPNB1

1.58e-06229122826472760
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

CHERP HYOU1 POLA1 XPO1 DDX6 PPP2R1A CYFIP1 VPS35 EIF3C RPA1 TNPO3 KPNB1

2.72e-066381221233239621
Pubmed

Changing expression and subcellular distribution of karyopherins during murine oogenesis.

XPO1 KPNA7 KPNB1

3.48e-069122326399853
Pubmed

Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.

CYFIP2 PPP2R1A CYFIP1 CCDC88A PNMA3

4.27e-0668122514676191
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

ECD XPO1 TUBGCP4 TEX10 PPP2R1A CYFIP1 SCCPDH VPS35 LTN1 TNPO3 KPNB1

4.80e-065601221135241646
Pubmed

DNA sequence and analysis of human chromosome 9.

DYNC2I2 NOL6 TEX10 AOPEP ELAVL2 OSTF1 STKLD1 UHRF2 DCTN3

6.72e-06370122915164053
Pubmed

Identification of a candidate gene for astigmatism.

MAML2 DNAH5 BICC1

6.81e-0611122323322567
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

ABR HYOU1 ABCC5 XPO1 NPLOC4 DDX6 PPP2R1A CYFIP1 CCDC88A VANGL1 RPA1 KPNB1

7.79e-067081221239231216
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

HYOU1 DYNC2I2 ECD OBSL1 XPO1 NPLOC4 PPP2R1A CYFIP1 VANGL1 VPS35 LTN1 EIF3C TNPO3 KPNB1

8.63e-069741221428675297
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

CHERP HYOU1 DNAH10 POLA1 NOL6 XPO1 CYFIP2 DDX6 PPP2R1A CYFIP1 PI4KA VPS35 EIF3C RPA1 CTSD DNAH5 KPNB1

1.03e-0514251221730948266
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

CLTCL1 HYOU1 ECD NOL6 XPO1 TUBGCP4 NPLOC4 LGALS3BP DDX6 PPP2R1A SCCPDH VPS35 LTN1 EIF3C RPA1 TNPO3 KPNB1

1.18e-0514401221730833792
Pubmed

Different dysregulations of CYFIP1 and CYFIP2 in distinct types of dementia.

CYFIP2 CYFIP1

1.22e-052122238128786
Pubmed

Timed interactions between viral and cellular replication factors during the initiation of SV40 in vitro DNA replication.

POLA1 RPA1

1.22e-052122217666013
Pubmed

G9A promotes tumor cell growth and invasion by silencing CASP1 in non-small-cell lung cancer cells.

CASP1 EHMT2

1.22e-052122228383547
Pubmed

Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis.

WNK1 KLHL3

1.22e-052122232790646
Pubmed

Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression.

WNK1 KLHL3

1.22e-052122233682442
Pubmed

Cytoplasmic FMRP interacting protein 1/2 (CYFIP1/2) expression analysis in autism.

CYFIP2 CYFIP1

1.22e-052122229752658
Pubmed

Characterization of the Importin-β binding domain in nuclear import receptor KPNA7.

KPNA7 KPNB1

1.22e-052122231642884
Pubmed

Interaction of DNA polymerase alpha-primase with cellular replication protein A and SV40 T antigen.

POLA1 RPA1

1.22e-05212221311258
Pubmed

Overcoming radio-resistance in esophageal squamous cell carcinoma via hypermethylation of PIK3C3 promoter region mediated by KDM5B loss.

KDM5B PIK3C3

1.22e-052122235333349
Pubmed

C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response.

CYFIP2 CYFIP1

1.22e-052122224357318
Pubmed

Suppression of progression and metastasis of established colon tumors in mice by intravenous delivery of short interfering RNA targeting KITENIN, a metastasis-enhancing protein.

LGALS3BP VANGL1

1.22e-052122216204073
Pubmed

Mutation of Vps54 causes motor neuron disease and defective spermiogenesis in the wobbler mouse.

VPS54 WDPCP

1.22e-052122216244655
Pubmed

Cytoplasmic FMR1 interacting protein (CYFIP) family members and their function in neural development and disorders.

CYFIP2 CYFIP1

1.22e-052122234327661
Pubmed

Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion.

CYFIP2 CYFIP1

1.22e-052122235567753
Pubmed

Cyfip1 Haploinsufficiency Increases Compulsive-Like Behavior and Modulates Palatable Food Intake in Mice: Dependence on Cyfip2 Genetic Background, Parent-of Origin, and Sex.

CYFIP2 CYFIP1

1.22e-052122231324746
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

DDX59 CHERP HYOU1 XPO1 LARS2 WNK1 LGALS3BP ATF6 PPP2R1A CYFIP1 PIK3C3 VANGL1 RPA1 CTSD TNPO3 KPNB1

1.28e-0512971221633545068
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH3 DNAH10 DNAH5

1.49e-051412239373155
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

CHERP HYOU1 NOL6 OBSL1 XPO1 TEX10 LGALS3BP DDX6 PPP2R1A VANGL1 PI4KA EIF3C RPA1 KPNB1

1.51e-0510241221424711643
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

HYOU1 XPO1 TEX10 CYFIP2 PPP2R1A CCDC88A SCCPDH PPP3R1 VANGL1 PI4KA LTN1 EIF3C RPA1 KPNB1

1.97e-0510491221427880917
Pubmed

Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination.

VPS54 KLHL20 GMCL1 PIK3C3

2.29e-0547122426687681
Pubmed

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.

PIK3C3 PIK3CA PI4KA

2.76e-0517122325327288
Pubmed

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.

XPO1 LARS2 NPLOC4 PPP2R1A VPS35 ZNF75D EIF3C RPA1 KPNB1

3.21e-05451122936168627
Pubmed

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.

ECD XPO1 NPLOC4 DDX6 PPP2R1A CCDC88A PI4KA VPS35 CTSD KPNB1

3.50e-055711221037167062
Pubmed

Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.

DYNC2I2 POLA1 NOL6 XPO1 PI4KA VPS35 CTSD

3.61e-05257122730945288
Pubmed

Human cell DNA replication is mediated by a discrete multiprotein complex.

POLA1 RPA1

3.65e-053122211968016
Pubmed

The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis.

PPP2R1A PIK3CA

3.65e-053122227348297
Pubmed

WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO4.

WNK1 KLHL3

3.65e-053122229904119
Pubmed

Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice.

WNK1 KLHL3

3.65e-053122224821705
Pubmed

The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.

XPO1 KPNB1

3.65e-053122219117056
Pubmed

Novel importin-alpha family member Kpna7 is required for normal fertility and fecundity in the mouse.

KPNA7 KPNB1

3.65e-053122220699224
Pubmed

Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells.

ATF6 PIK3C3

3.65e-053122228157699
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

DDX59 HYOU1 POLA1 ECD XPO1 WNK1 LRRC8D NPLOC4 LGALS3BP DDX6 PPP2R1A CYFIP1 VPS35 EIF3C CTSD KPNB1

3.67e-0514151221628515276
Pubmed

Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14.

VPS54 XPO1 WDPCP

3.92e-0519122312174196
Pubmed

Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns.

PDPK2P VPS35 DCTN3

3.92e-0519122333660780
Pubmed

Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).

CHERP EHMT2 UHRF2 RPA1

4.28e-0555122427114453
Pubmed

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.

DNAH3 CLTCL1 CHERP ECD WNK1 CYFIP2 DDX6 PPP2R1A CYFIP1 EIF3C DCTN3 KPNB1

4.52e-058471221235235311
Pubmed

Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.

GAD2 PCDHB12 PCDHB11 PCDHGB4

4.93e-0557122432633719
Pubmed

NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons.

CYFIP2 CYFIP1 PIK3CA

6.18e-0522122321946561
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

DDX59 TRPM7 POLA1 VPS54 XPO1 MED13L WNK1 DDX6 BEND6 EHMT2 PIK3CA VPS35 ELAVL2 MAML2 ABHD11

6.58e-0513271221532694731
Pubmed

Characterization of nuclear import and export signals determining the subcellular localization of WD repeat-containing protein 42A (WDR42A).

XPO1 KPNB1

7.29e-054122222500989
Pubmed

Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1.

XPO1 KPNB1

7.29e-054122216552725
Pubmed

Type I interferon signaling mediates Mycobacterium tuberculosis-induced macrophage death.

CASP1 STAT2

7.29e-054122233125053
Pubmed

Pseudohypoaldosteronism Type II

WNK1 KLHL3

7.29e-054122222073419
Pubmed

Retrolinkin recruits the WAVE1 protein complex to facilitate BDNF-induced TrkB endocytosis and dendrite outgrowth.

CYFIP2 CYFIP1

7.29e-054122227605705
Pubmed

Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.

CYFIP2 CYFIP1

7.29e-054122220228810
Pubmed

Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes.

DNAH3 DNAH10

7.29e-054122211175280
Pubmed

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.

WNK1 KLHL3

7.29e-054122223576762
Pubmed

Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells.

PPP2R1A KPNB1

7.29e-054122220711181
Pubmed

Interchangeable functions of Arabidopsis PIROGI and the human WAVE complex subunit SRA1 during leaf epidermal development.

CYFIP2 CYFIP1

7.29e-054122215294869
Pubmed

A dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replication.

POLA1 RPA1

7.29e-054122212181327
Pubmed

Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1.

XPO1 KPNB1

7.29e-054122210779340
Pubmed

Overexpression of PIK3CA in murine head and neck epithelium drives tumor invasion and metastasis through PDK1 and enhanced TGFβ signaling.

PDPK2P PIK3CA

7.29e-054122226876212
Pubmed

Exploring the link between MORF4L1 and risk of breast cancer.

KPNA7 RPA1 KPNB1

8.08e-0524122321466675
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

ABR OBSL1 TEX10 CYFIP2 DDX6 TYRO3 PPP2R1A CYFIP1 RTL1 OSTF1 EIF3C SLC4A4

8.93e-059101221236736316
Pubmed

Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane.

STAT2 KPNB1

1.21e-045122217596301
Pubmed

CRM1-mediated recycling of snurportin 1 to the cytoplasm.

XPO1 KPNB1

1.21e-045122210209022
Pubmed

RPA phosphorylation in mitosis alters DNA binding and protein-protein interactions.

POLA1 RPA1

1.21e-045122212641457
Pubmed

Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes.

VPS54 CTSD

1.21e-045122218367545
Pubmed

Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1.

WNK1 PIK3CA

1.21e-045122221355052
Pubmed

Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.

WNK1 KLHL3

1.21e-045122224641320
Pubmed

Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase.

PIK3CA PI4KA

1.21e-04512228246987
Pubmed

TRPM7 ion channels are required for sustained phosphoinositide 3-kinase signaling in lymphocytes.

TRPM7 PIK3CA

1.21e-045122218590694
Pubmed

Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis.

CASP1 WNK1

1.21e-045122234315884
Pubmed

LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway.

HYOU1 XPO1 PPP2R1A VPS35 KPNB1

1.49e-04142122530809309
Pubmed

Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.

CDH26 PCDHB12 PCDHB11 PCDHGB4

1.60e-0477122410835267
Pubmed

A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.

CYFIP2 CYFIP1

1.81e-046122211438699
Pubmed

A small family of sushi-class retrotransposon-derived genes in mammals and their relation to genomic imprinting.

RTL4 RTL1

1.81e-046122216155747
Pubmed

PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway.

PDPK2P PIK3CA

1.81e-046122224169049
Pubmed

Sequestration of Gβγ by deubiquitinated arrestins into the nucleus as a novel desensitization mechanism of G protein-coupled receptors.

USP33 KPNB1

1.81e-046122236658650
Pubmed

Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors.

KPNA7 KPNB1

1.81e-046122220701745
Pubmed

Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import.

XPO1 KPNB1

1.81e-046122212176322
Pubmed

Differential cell-type-expression of CYFIP1 and CYFIP2 in the adult mouse hippocampus.

CYFIP2 CYFIP1

1.81e-046122231853374
Pubmed

Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain.

XPO1 KPNB1

1.81e-046122210202161
Pubmed

Phosphorylation of Crm1 by CDK1-cyclin-B promotes Ran-dependent mitotic spindle assembly.

XPO1 KPNB1

1.81e-046122223729730
Pubmed

Suppression of receptor interacting protein 140 repressive activity by protein arginine methylation.

XPO1 KPNB1

1.81e-046122217053781
Pubmed

The ZNF217 oncogene is a candidate organizer of repressive histone modifiers.

KDM5B EHMT2

1.81e-046122219242095
Pubmed

MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.

POLA1 FRYL XPO1 WNK1 LTN1

1.93e-04150122522678362
Pubmed

Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase.

PPP2R1A RPA1 KPNB1

1.94e-0432122323277564
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

POLA1 NOL6 LDAH DDX6 CYFIP1 EHMT2 LTN1 EIF3C RPA1 DNAH5

1.95e-047041221029955894
Pubmed

Mapping the Genetic Landscape of Human Cells.

TRPM7 POLA1 XPO1 TUBGCP4 LARS2 PPP2R1A LTN1 EIF3C

1.99e-04451122830033366
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

CHERP DYNC2I2 ECD XPO1 TUBGCP4 LGALS3BP DDX6 PPP2R1A EHMT2 EIF3C MORC3 DCTN3 KPNB1

2.16e-0411551221320360068
Pubmed

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.

HYOU1 NOL6 XPO1 DDX6 PPP2R1A ELAVL2 EIF3C RPA1 TNPO3 KPNB1

2.19e-047141221028302793
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

CDH26 ABR STXBP5L ENC1 LHPP FRYL VPS54 LRRC8D NPLOC4 ATF6 PIK3C3 AOPEP OSTF1 ARHGEF37 ADGRD1

2.32e-0414891221528611215
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

OBSL1 TUBGCP4 WNK1 PLEKHH3 DDX6 PPP2R1A FRY ELAVL2

2.35e-04462122831138677
Pubmed

Defining the membrane proteome of NK cells.

CLTCL1 CHERP ABR HYOU1 XPO1 TUBGCP4 LRRC8D CYFIP2 DDX6 SCCPDH PIK3C3 PI4KA KPNB1

2.41e-0411681221319946888
Pubmed

Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.

DNAH3 DNAH5

2.53e-04712229256245
Cytoband2p15

XPO1 WDPCP PPP3R1

7.79e-053112232p15
Cytoband5q31

PCDHB12 PCDHB11 KLHL3 PCDHGB4

2.61e-0411512245q31
Cytoband15q15

TUBGCP4 TYRO3

4.54e-0412122215q15
GeneFamilyDyneins, axonemal

DNAH3 DNAH10 DNAH5

7.71e-0517903536
GeneFamilyArmadillo repeat containing|Importins

KPNA7 TNPO3 KPNB1

9.22e-0518903596
GeneFamilyBasic leucine zipper proteins|BTB domain containing

ENC1 KLHL20 LGALS3BP KLHL3 GMCL1

5.51e-04134905861
GeneFamilyPhosphatidylinositol 3-kinase subunits

PIK3C3 PIK3CA

6.73e-048902831
GeneFamilyKelch like|BTB domain containing

ENC1 KLHL20 KLHL3

1.19e-0342903617
CoexpressionGSE15330_HSC_VS_MEGAKARYOCYTE_ERYTHROID_PROGENITOR_IKAROS_KO_UP

FRYL VPS54 LGALS3BP PITPNM1 CCDC88C PIK3CA MORC3 DCTN3

4.30e-062001218M7020
CoexpressionGSE21033_CTRL_VS_POLYIC_STIM_DC_24H_UP

TMEM154 PIGV PITPNM1 KLHL3 CPQ OSTF1 ABHD11

8.62e-061571217M7731
CoexpressionWOOD_EBV_EBNA1_TARGETS_UP

CHERP HYOU1 TUBGCP4 LGALS3BP TYRO3 CTSD

1.24e-051101216M1696
CoexpressionGSE24574_BCL6_LOW_TFH_VS_NAIVE_CD4_TCELL_UP

STAT2 PITPNM1 SCCPDH EHMT2 UHRF2 UNC13A DCTN3

3.85e-051981217M8336
CoexpressionSAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP

CASP1 ATF6 PPP3R1 PIK3CA USP33

3.96e-05821215M9224
CoexpressionGSE39820_TGFBETA3_IL6_VS_TGFBETA3_IL6_IL23A_TREATED_CD4_TCELL_DN

DDX59 DYNC2I2 CASP1 ABCC5 LGALS3BP TERB1 OSTF1

4.11e-052001217M5621
ToppCelldroplet-Marrow-nan-3m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TUBGCP4 TLR8 PLEKHH3 CCDC88A GVINP1 UNC5CL MAML2 STKLD1

2.25e-0816912285f5bec13208f4c3b6eacbba180c8a6402743b76e
ToppCellmild-Myeloid-Immature_Neutrophils_1|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

CLTCL1 DNAH10 VEPH1 VPS54 CYFIP2 ZNF75D CSGALNACT1

9.20e-07189122794dd5d4d815449feff7ce157fe7f8234f7c81422
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM7 ABCC5 WNK1 KLHL3 MAML2 BICC1

1.11e-0518212265f513bbb7125956eb528e3120de3fd776770a7c3
ToppCellCOVID-19-kidney-DCT|kidney / Disease (COVID-19 only), tissue and cell type

TRPM7 ABCC5 WNK1 KLHL3 CSGALNACT1 BICC1

1.33e-051881226df1fd0819d301679f3c9ea404e942e39095912eb
ToppCellCiliated-cil-3|World / Class top

DNAH3 CDH26 DNAH10 LGALS3BP CRNN DNAH5

1.50e-0519212264989ebb8812b8af1870599acd932849122c05a29
ToppCellHippocampus-Macroglia-CSF_related-EPENDYMAL-Ependymal.Ccdc153_(Ccdc153)|Hippocampus / BrainAtlas - Mouse McCarroll V32

DNAH3 CDH26 DNAH10 UNC5CL STKLD1

1.77e-05117122591936a3ffbfa29024ced9d01df962b4ccfaf8966
ToppCellHippocampus-Macroglia-CSF_related-EPENDYMAL-Ependymal.Ccdc153_(Ccdc153)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

DNAH3 CDH26 DNAH10 UNC5CL STKLD1

1.77e-051171225e33ec9044541d2ef53f6633891238559b01b7957
ToppCellHippocampus-Macroglia-CSF_related-EPENDYMAL-Ependymal.Ccdc153_(Ccdc153)--|Hippocampus / BrainAtlas - Mouse McCarroll V32

DNAH3 CDH26 DNAH10 UNC5CL STKLD1

1.77e-051171225454efceabe739cdf293f81c8a938811f12321a47
ToppCellHippocampus-Macroglia-CSF_related-EPENDYMAL|Hippocampus / BrainAtlas - Mouse McCarroll V32

DNAH3 CDH26 DNAH10 UNC5CL STKLD1

1.77e-051171225409b3ab16786bced8c9bc9c0e89b0078402f365a
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)-FREM3---L2-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

STXBP5L ENC1 CCDC88C MED12L SLC4A4 BICC1

1.89e-0520012269c89e91bb630cc306a820927a36ea6fb3d13e9d7
ToppCellHematolymphoid-Microglia-TYROBP----L1-3|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

ABR MED13L CYFIP1 MED12L MAML2 CSGALNACT1

1.89e-052001226a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCellHematolymphoid-Microglia-TYROBP--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

ABR MED13L CYFIP1 MED12L MAML2 CSGALNACT1

1.89e-052001226dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCellHematolymphoid-Microglia-TYROBP-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

ABR MED13L CYFIP1 MED12L MAML2 CSGALNACT1

1.89e-0520012263bba5219453322198e8fdb0921d5f8c403598751
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)-FREM3-|Neuronal / cells hierarchy compared to all cells using T-Statistic

STXBP5L ENC1 CCDC88C MED12L SLC4A4 BICC1

1.89e-0520012268821574d17b55dfea3ca0204e6b4c0ca6b19588a
ToppCellHematolymphoid-Microglia|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

ABR MED13L CYFIP1 MED12L MAML2 CSGALNACT1

1.89e-05200122621bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)|Neuronal / cells hierarchy compared to all cells using T-Statistic

STXBP5L ENC1 CCDC88C MED12L SLC4A4 BICC1

1.89e-0520012260f23e72649a274043bf23e0952a9b5707c516acf
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)-FREM3--|Neuronal / cells hierarchy compared to all cells using T-Statistic

STXBP5L ENC1 CCDC88C MED12L SLC4A4 BICC1

1.89e-05200122696b1d2e70fbbba744fd4356a70efcf356aca9abc
ToppCellHematolymphoid-Microglia-TYROBP---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

ABR MED13L CYFIP1 MED12L MAML2 CSGALNACT1

1.89e-052001226a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCellHematolymphoid-Microglia-TYROBP|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

ABR MED13L CYFIP1 MED12L MAML2 CSGALNACT1

1.89e-05200122633036d21c1c82109284473a515c4f890b33fdd5c
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)-FREM3|Neuronal / cells hierarchy compared to all cells using T-Statistic

STXBP5L ENC1 CCDC88C MED12L SLC4A4 BICC1

1.89e-052001226ad6f1d4d7f5d7bab2ba2e4fff58c535290065c0e
ToppCellE18.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_immature|E18.5-samps / Age Group, Lineage, Cell class and subclass

CPA5 ENC1 PCDHGB4 ELAVL2 QRSL1

3.41e-051341225a4b9163af68e92d047b0005fd2f98aa63846b65b
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM7 ABCC5 WNK1 KLHL3 AOPEP

7.03e-0515612254d2679e7639758c49fc25a2deb9109b08f0a3e57
ToppCellCD8+_Memory_T_cell-FLU-1|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

PPP1R3B SIDT1 UNC5CL MED12L MAML2

8.40e-05162122576f39935763848ea6e7917b2f9f1432c543063d9
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 LHPP KLHL3 DNAH5 CSGALNACT1

9.16e-0516512251703d3eb644b3c743ad3c5532b1d29ea010c79c8
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C15orf62 GAD2 TERB1 ELAVL2 PNMA3

9.42e-051661225548d0d6c0ffd564036ddba78620734220ebb73d7
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C15orf62 GAD2 TERB1 ELAVL2 PNMA3

9.42e-05166122580e164a89d22098cabe4a99a78283ba69ea0561e
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 VEPH1 LARS2 ELAVL2 DNAH5

1.02e-04169122512bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABR VEPH1 PITPNM1 CCDC88A GVINP1

1.11e-0417212253f784aed340b50ddbec3f7dc0a5279180d38a2bb
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MXD3 TRPM7 WNK1 KLHL3 MAML2

1.14e-0417312250c74bdb40e635d906fd180412c23bf7fed61621e
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ENC1 TYRO3 AOPEP CSGALNACT1 ADGRD1

1.21e-041751225c227fc5d1ccb69b82a96a6354913cafaf27d0eec
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCC5 LARS2 WNK1 MED12L MAML2

1.21e-0417512251ea6cf9da26601646f57fa14d558a5e9e1f0b345
ToppCellwk_20-22-Hematologic_Lymphocytic-B-Pro-B/Pre-B_transition|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

C15orf62 LHPP MED13L CYFIP2 MAP3K10

1.21e-041751225f86d2d212f8314b2410d5d84ef092b0b38607ea4
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CDH26 SIDT1 LIPH SLC4A4 DNAH5

1.24e-0417612253bbac5c2397535631fce8fa98f6ddb4fe0260351
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DNAH10 STXBP5L RTL1 MED12L UNC13A

1.27e-0417712258abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCellAdult-Epithelial-club_cell-D122|Adult / Lineage, Cell type, age group and donor

CDH26 ENC1 ABCC5 TYRO3 LIPH

1.31e-04178122535a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCellfacs-Liver-Non-hepatocytes-3m-Lymphocytic-T_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBC1D22B CYFIP2 PLEKHH3 BEND6 HERC3

1.38e-04180122587347af8f28cf7c486c19f3f98c0afb022c323b5
ToppCellAdult-Immune-T_lymphocyte-D122|Adult / Lineage, Cell type, age group and donor

NUGGC SIDT1 CYFIP2 CCDC88C PNMA3

1.38e-04180122506c371d0f0c5a7b234dd143e98800e19af95a8b5
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CDH26 VEPH1 ABCC5 LIPH DNAH5

1.45e-041821225215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L2-3_LINC00507_RPL9P17|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ENC1 TYRO3 CCDC88C SLC4A4 BICC1

1.49e-0418312251645d4a55cd8c22d6eb47fc5c6b1e576c454f111
ToppCellfacs-Liver-Non-hepatocytes-3m-Lymphocytic-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAD2 TMEM154 CYFIP2 GVINP1 UNC5CL

1.53e-0418412258fc047977fad38fcd26eebcc279a688efd342ed8
ToppCelldroplet-Liver-Hepatocytes-18m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABR NOL6 CMTR2 UNC13A

1.53e-0498122495162072f3afc95e46f29db3d79ebd930bc09726
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-B_cells-Pre-B|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C15orf62 LHPP CYFIP2 UHRF2 QRSL1

1.56e-0418512250fa7970709dc957dea95fabbd83263a0335babd5
ToppCelldroplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NUGGC TTLL5 OBSL1 BICC1 ADGRD1

1.56e-0418512251b990e3089772be2b38c6d7ea0d1bf22461ae3ea
ToppCelldroplet-Thymus-nan-24m-Myeloid-Plasma_cells_and_B_cells|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C15orf62 NUGGC OBSL1 TMEM154 ATF6

1.56e-041851225e583f6601f9ed79b0b23d2f9426a4ba8b969230b
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

KDM5B CPA5 ABCC5 EIF3C KPNB1

1.64e-041871225c8278525b3e1d3f3f4defcaf109cce22dd2e157a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM7 WNK1 KLHL3 MED12L MAML2

1.69e-041881225bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCellfacs-Lung-nan-3m-Endothelial-Capillary_Aerocyte_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRY SCCPDH VANGL1 VPS35 CSGALNACT1

1.73e-04189122509dd2b3d89416192e84abe302a6237b8f3fdcb6e
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_3|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

KDM5B CPA5 ABCC5 EIF3C KPNB1

1.73e-04189122599b01893da9f9f7c9528afaffad178285211738b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM7 WNK1 KLHL3 MED12L MAML2

1.73e-041891225977a813e5d7a5a561c1fced2bbf21c20056b88d8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM7 ABCC5 WNK1 KLHL3 CSGALNACT1

1.73e-041891225975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM7 ABCC5 WNK1 KLHL3 CSGALNACT1

1.73e-0418912257eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

VEPH1 CYFIP2 FRY MAML2 BICC1

1.73e-041891225830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCellAdult-Epithelial-club_cell|Adult / Lineage, Cell type, age group and donor

CDH26 ENC1 ABCC5 LIPH DNAH5

1.77e-041901225756bff697d30aec56c0ebfca94295f084a15bf37
ToppCellfacs-GAT-Fat-3m|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LARS2 WNK1 CYFIP1 PPP3R1 VPS35

1.77e-0419012251d92be1b41cff59e834a9d28868f554bd1f3e471
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM7 WNK1 KLHL3 MED12L MAML2

1.77e-041901225e252e925600e6457fa6e362a55217f4cffa75cdb
ToppCellfacs-Pancreas-Endocrine-3m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STXBP5L LGALS3BP DDX6 CCDC88A CPQ

1.81e-041911225b3de0393d6510543533cd851e47a0f95739a0e4e
ToppCell15-Airway-Epithelial-Secretory_progenitor|Airway / Age, Tissue, Lineage and Cell class

PPP1R3B VEPH1 LGALS3BP LIPH SLC4A4

1.81e-0419112259359d8c6b00f8977848986baf3c950157adf4c9a
ToppCellcontrol-Myeloid-Immature_Neutrophils_1|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

CLTCL1 VEPH1 VPS54 CYFIP2 CSGALNACT1

1.86e-0419212259f12b79d661ef0f57c2c924e8ecc24a46ea996d2
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM7 OBSL1 WNK1 CYFIP2 CTSD

1.86e-04192122532e4a180037e516c5cc798cd9dada9385e0f43ae
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

MED13L AOPEP MAML2 SLC4A4 BICC1

1.86e-041921225e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

AOPEP MAML2 DNAH5 CSGALNACT1 BICC1

1.95e-041941225e577d9e88390b36b5a09b97fe1026089892275a3
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM7 WNK1 KLHL3 MED12L MAML2

2.00e-041951225a38d9dc6192aea673d96fda6b25e81223fda3abf
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM7 OBSL1 WNK1 CYFIP2 CTSD

2.00e-0419512253123e02d2894c83962ba402085b5e6422ebf8c73
ToppCellsevere-Myeloid-Immature_Neutrophils_1|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

CLTCL1 VPS54 CYFIP2 CTSD CSGALNACT1

2.00e-041951225becad890a420267ca41e98e61a8da343b51e1945
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

VEPH1 CYFIP2 SCCPDH LIPH BICC1

2.05e-041961225c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM7 ABCC5 WNK1 KLHL3 CTSD

2.05e-041961225f40d10ea7714067585493fdc89744714aa427de8
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM7 ABCC5 WNK1 KLHL3 CTSD

2.05e-041961225b8350340d86e4524e9616a427e7f2e116a6fb3be
ToppCellPBMC-Control-cDC_3|Control / Compartment, Disease Groups and Clusters

WNK1 CYFIP2 PIK3CA PI4KA EIF3C

2.05e-04196122509d197b321ff9f13c0672ea059c850845b0dbbd5
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PLB1 VEPH1 AOPEP UNC5CL DNAH5

2.09e-041971225b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCellControl_saline-Epithelial_airway|Control_saline / Treatment groups by lineage, cell group, cell type

DNAH3 CDH26 DNAH10 CRNN DNAH5

2.14e-041981225e6863238e022ecfb6a8e3f4b7661b376e92c5d8f
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

VEPH1 OBSL1 CYFIP2 UNC5CL SLC4A4

2.14e-041981225285f729140b1df029c24f6ca1d2438470ac51794
ToppCellControl_saline-Epithelial_airway-airway_epithelial|Control_saline / Treatment groups by lineage, cell group, cell type

DNAH3 CDH26 DNAH10 CRNN DNAH5

2.14e-041981225e7aa42e5fbd42c68f50cda4a8f3aa464c862c007
ToppCellLPS_IL1RA-Epithelial_airway-airway_epithelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

DNAH3 CDH26 DNAH10 CRNN DNAH5

2.25e-042001225cf191104484bfb2b9f87de416b9453135f8833c1
ToppCellfacs-Brain_Non-Myeloid-Hippocampus|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LARS2 WNK1 LDAH CCDC88A VPS35

2.25e-042001225fc28f71ca1cd0fdae66009ae5afe175d22f2bd8c
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DNAH3 CDH26 DNAH10 CRNN DNAH5

2.25e-042001225da12821e8a0657869ca0f75d351cce2d7605a505
ToppCellLPS_IL1RA-Epithelial_airway|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

DNAH3 CDH26 DNAH10 CRNN DNAH5

2.25e-042001225a5ae33dd4dc1ff6e1a1eec22c4d523d5ab657607
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

FRYL XPO1 MED13L STAT2 DDX6

2.25e-04200122512f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte|Control_saline / Treatment groups by lineage, cell group, cell type

ABR PLEKHH3 TYRO3 SLC4A4 ADGRD1

2.25e-042001225cb7ef774b6d300f8019c5b16a04e3ebd165e4f1c
ToppCellNeuronal-Excitatory|Neuronal / cells hierarchy compared to all cells using T-Statistic

STXBP5L ENC1 SLC22A24 TYRO3 CSGALNACT1

2.25e-0420012254409065bc7aa995354c71e0f9d6f3726cf393d6b
ToppCellCOVID-19-Myeloid-MoAM2,_CCL18|Myeloid / Condition, Lineage and Cell class

HYOU1 ABCC5 CYFIP1 CCDC88A CTSD

2.25e-042001225a60346c5ea7a3dae1ad3c5dc6c6eca65b64c6888
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Neuronal-Intermediate|2m / Sample Type, Dataset, Time_group, and Cell type.

KDM5B ABR ENC1 FRY ELAVL2

2.25e-0420012252a635694844ddabcd98462c5636a6f41a3f08a46
ToppCellLPS_IL1RA_TNF-Epithelial_airway|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DNAH3 CDH26 DNAH10 CRNN DNAH5

2.25e-04200122572c1d9eeaed4b3ee6b6c602e8aa29efc2e8744eb
Diseasechromosome 15q11.2 deletion syndrome (implicated_via_orthology)

CYFIP2 CYFIP1

4.74e-0531182DOID:0060393 (implicated_via_orthology)
DiseasePseudohypoaldosteronism type 2A

WNK1 KLHL3

9.46e-0541182cv:C1840389
DiseasePseudohypoaldosteronism, type 2

WNK1 KLHL3

9.46e-0541182cv:C1449844
Diseasepseudohypoaldosteronism (implicated_via_orthology)

WNK1 KLHL3

2.35e-0461182DOID:4479 (implicated_via_orthology)
Diseasepseudohypoaldosteronism (is_implicated_in)

WNK1 KLHL3

4.37e-0481182DOID:4479 (is_implicated_in)
Diseaseneural tube defect (implicated_via_orthology)

DYNC2I2 VANGL1

5.60e-0491182DOID:0080074 (implicated_via_orthology)
Diseasediffuse scleroderma

DDX6 TNPO3

5.60e-0491182EFO_0000404
DiseasePseudohypoaldosteronism

WNK1 KLHL3

6.99e-04101182C0033805
DiseaseHyperpotassemia and Hypertension, Familial

WNK1 KLHL3

6.99e-04101182C2713447
DiseasePseudohypoaldosteronism, Type I

WNK1 KLHL3

6.99e-04101182C0268436
DiseasePseudohypoaldosteronism, Type I, Autosomal Recessive

WNK1 KLHL3

6.99e-04101182C1449843
DiseasePseudohypoaldosteronism, Type II

WNK1 KLHL3

6.99e-04101182C1449844
DiseasePseudohypoaldosteronism, Type I, Autosomal Dominant

WNK1 KLHL3

6.99e-04101182C1449842
Diseasealcohol use disorder (implicated_via_orthology)

GAD2 KDM5B PPP1R3B PDPK2P UNC13A

1.15e-031951185DOID:1574 (implicated_via_orthology)
Diseasesusceptibility to bacterial meningitis measurement

STXBP5L SLC4A4 DNAH5

1.19e-03521183EFO_0008411
Diseasechromosome 22q11.2 deletion syndrome, distal (implicated_via_orthology)

PI4KAP2 PI4KA

1.40e-03141182DOID:0060413 (implicated_via_orthology)
DiseaseAstigmatism

NPLOC4 MAML2 DNAH5 BICC1

1.82e-031291184HP_0000483
Diseaseglycine measurement

TUBGCP4 GVINP1 UHRF2 KPNB1

2.27e-031371184EFO_0009767
DiseaseSchizophrenia

GAD2 LARS2 PITPNM1 CYFIP1 PPP3R1 PIK3C3 PIK3CA PI4KA VPS35 ELAVL2

2.92e-0388311810C0036341
Diseaseesophagus squamous cell carcinoma (is_marker_for)

KDM5B XPO1 EHMT2

3.29e-03741183DOID:3748 (is_marker_for)
DiseaseLiver Cirrhosis, Experimental

PPP1R3B ENC1 CASP1 ABCC5 FRY CPQ UNC5CL SLC4A4 CSGALNACT1

3.96e-037741189C0023893

Protein segments in the cluster

PeptideGeneStartEntry
LELRQLQPMFTLQVV

VANGL1

241

Q8TAA9
NVLQPIMDLLDSNLT

UNC13A

1346

Q9UPW8
MFENEFLLLLNSPTI

ABR

411

Q12979
IAQLLPQEDLEALVM

PPP2R1A

231

P30153
LLSQDFVQIMEDIIL

DDX6

251

P26196
EEVMSLLQPLNITQV

CPQ

386

Q9Y646
LNMANTLINVIVPLA

CSGALNACT1

256

Q8TDX6
NFAILMQVVPLELAR

ADGRD1

546

Q6QNK2
NTQLMEILNTLFFLP

ALS2

826

Q96Q42
LLVAELPQFNQLVMQ

ARHGEF37

401

A1IGU5
YEIMSQDLQDLLPQL

ABHD11

116

Q8NFV4
LPLNDLMQSVLQFLQ

GVINP1

1321

Q7Z2Y8
DSPQQVLQFVPMEVL

CMTR2

716

Q8IYT2
VILMLLDNLDPNFQS

EHMT2

666

Q96KQ7
ILSQDFLQMLLENIP

AOPEP

621

Q8N6M6
MSIVLPAININENVI

ATF6

591

P18850
EEFMSLPELQQNPLV

PPP3R1

41

P63098
VDPQFIAQLMEQLDV

BICC1

366

Q9H694
MAPVDVDLNLVSNIL

ECD

591

O95905
VMLQVLPQAVTQFEE

BEND6

96

Q5SZJ8
QVVMNLDSRLLIFPL

GMCL1

486

Q96IK5
IFQSLPNLIMEDAEL

PCDHGB4

346

Q9UN71
QMLVNDQLIPFIDAV

LTN1

431

O94822
QSLALLEVEALPLQM

OBSL1

1796

O75147
QLQVVPLFGDMQIEL

CYFIP1

301

Q7L576
PTLAFLQDVMNILLQ

GAD2

106

Q05329
MLVNFVPEENIISFL

OR8D2

81

Q9GZM6
AIDAGMLNVLPQLLQ

KPNA7

321

A9QM74
RLEVIEQSALFQMPL

MAP3K10

356

Q02779
MEPLASNIQVLLQAA

MXD3

1

Q9BW11
QLIFDLMEPALNING

MED12L

831

Q86YW9
QDVVRMLLSLQPFLQ

MED13L

1321

Q71F56
MLLSLQPFLQDAIQK

MED13L

1326

Q71F56
MLPEELFELQFNLSL

LGALS3BP

351

Q08380
SQFPNILLEQQMIFT

GLIPR1L2

276

Q4G1C9
ANLQNVFMLLTLEPL

HERC3

681

Q15034
MGFQQQVLDILENIP

DDX59

361

Q5T1V6
LQLTEGFALVMQQLP

DYNC2I2

306

Q96EX3
DVLAQQFAIMTPLLF

DCAF4L2

226

Q8NA75
ILNAMDIFIELVTNP

CPA5

226

Q8WXQ8
EVLQQLIVMNLPNVL

CCDC88C

91

Q9P219
VFLNQVMLQINPKLE

CCDC88A

46

Q3V6T2
QLLAMIVPDLDLQQV

MORC3

901

Q14149
VTLLLELNPDQSNLM

FRYL

1156

O94915
NEVMPLQDSISLLLE

NPLOC4

516

Q8TAT6
TELLALMSQLEQPEQ

VEPH1

201

Q14D04
QQLVVLAAEALPMLE

NOL6

971

Q9H6R4
EFNIPLEMLRELLNL

PI4KA

321

P42356
LDQFQLLFPSVMVVV

TUBGCP4

126

Q9UGJ1
MEAQLLQVSLPEIQE

KDM5B

1351

Q9UGL1
LVLMENVETVFQPIL

LIPH

431

Q8WWY8
NNAFQVLMELEKPVL

LHPP

136

Q9H008
PENILLNEDMYIQIT

PDPK2P

181

Q6A1A2
QLQVVPLFGDMQIEL

CYFIP2

301

Q96F07
ILLGLTNQPELQVMI

OR6C4

11

Q8NGE1
MPQLLQNINGIIEAF

CRNN

1

Q9UBG3
FILQIMCELNVLPLA

POLA1

751

P09884
PDIMSELLFQNNEII

PIK3CA

786

P42336
FQVLMKNPTQFLQIE

PCDHB12

106

Q9Y5F1
LQVLMQNPTQFLQIE

PCDHB11

106

Q9Y5F2
LMDPELQELFNELTN

MAML2

301

Q8IZL2
LPFQAEMFIQNVILV

ABCC5

986

O15440
FMLATQLNPLVEEEQ

RPA1

56

P27694
IINEELMASLDQPTQ

EIF3C

826

Q99613
SQVALLEQVNALVPM

DCTN3

96

O75935
LQIFDMALSPINIQL

WDPCP

401

O95876
QLQFSPEEVLGMVLN

HYOU1

141

Q9Y4L1
FMLLPANQLIDIISS

KLHL20

206

Q9Y2M5
QVPDILQLNAIFNML

CASP1

251

P29466
QLDMNEFDNLLQPII

CHERP

151

Q8IWX8
LLNFMITPLGLQDQL

DNAH3

3191

Q8TD57
KQVQFPVIQLQELMD

QRSL1

496

Q9H0R6
VLPVFDNLMQQKLVD

CTSD

211

P07339
DPLISQLLTFQPFMQ

C1orf112

311

Q9NSG2
QLLTFQPFMQVVLDS

C1orf112

316

Q9NSG2
LIVNYLPQNMTQEEL

ELAVL2

41

Q12926
LQSNIIPFCDEVMQL

KPNB1

681

Q14974
LMLFLSDINDNVPTL

CDH26

486

Q8IXH8
QVLLPAASLLQLMDV

KLHL3

121

Q9UH77
LQLPQDMVVQLLSSE

ENC1

186

O14682
MEELLFELQQTEPVN

FRY

1491

Q5TBA9
DISLNPQIIEQAVMI

DNAH10

961

Q8IVF4
IVMAPALEDVQQTLN

DNAH5

1021

Q8TE73
ISMIPIEIGLLQNLQ

LRRC8D

741

Q7L1W4
LDMPFNITELLDNIV

PPP1R3B

86

Q86XI6
IVEMLFTQPNIELNQ

OSTF1

121

Q92882
LAMIPIDQILNSFLA

RTL1

1051

A6NKG5
MQVEPSFLQAENLIL

RTL4

11

Q6ZR62
LINAIIQQAMFLPVS

NUGGC

116

Q68CJ6
ESQLLLQSPQVEEIM

PLEKHH3

726

Q7Z736
PTQLAEMIFNLLLEE

STAT2

101

P52630
DFQGLLMLLQNLPTI

TBC1D22B

461

Q9NU19
EFLQQPEVVQMAVLI

LARS2

831

Q15031
LVNTFLPQEMQILRV

SLC22A24

421

Q8N4F4
IDISGEPQFLELMQL

SCCPDH

121

Q8NBX0
QTLGAAVQPLLEQML

PNMA3

146

Q9UL41
ILNLFSLMVDANIPD

PIK3C3

816

Q8NEB9
LVNLVDFLNPTIMRQ

PLB1

896

Q6P1J6
PASQDMLALQIIDLF

PI4KAP2

341

A4QPH2
MVLIISLNLPLADEQ

STXBP5L

861

Q9Y2K9
EPLANISQIVDIFME

CLTCL1

541

P53675
SLLEEVLQMLREQFP

C15orf62

156

A8K5M9
LTLMLQALFNAIIPD

PIGV

21

Q9NUD9
MFLQSLVQEVELNIV

PITPNM1

1106

O00562
MIPNEILQTLLDLFF

UHRF2

781

Q96PU4
NMDVIIFILLEPVLQ

TLR8

971

Q9NR97
EVMPFIDEILNNINT

XPO1

606

O14980
LMLEQFLAILPEELQ

ZSCAN30

91

Q86W11
DVETFRNLLPLMLQI

STKLD1

266

Q8NE28
MDPSLQVQLFIEILN

VPS35

711

Q96QK1
LQQLIFVDVASMAPL

SIDT1

141

Q9NXL6
ELFEQLRMLLEPNSI

UNC5CL

411

Q8IV45
EPLQVMQQVLNIISL

TEX10

351

Q9NXF1
IENVETNLPLAMQLF

TNPO3

256

Q9Y5L0
EQILEMLVLEQFLSI

ZNF75D

86

P51815
IPALLVTILIFMDQQ

SLC4A4

786

Q9Y6R1
ENQLEFILMVLIPLI

TMEM154

71

Q6P9G4
ILQMNAIPAAQVILN

TTC37

956

Q6PGP7
PEEIATIMVNNDFIL

WNK1

1156

Q9H4A3
LPLMIQALTESQNEE

TERB1

341

Q8NA31
TFVVLVQMEQLPSVQ

TRPM7

871

Q96QT4
NLPLQTLIRFMVDIA

TYRO3

626

Q06418
ISNLLNIMEPSLLQF

USP33

726

Q8TEY7
ETQELEPKFNLMQIL

TTLL5

651

Q6EMB2
IFDLLPEEQTQMLFL

VPS54

901

Q9P1Q0
VMNLENEFSPLNILE

LDAH

216

Q9H6V9