Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	lipid kinase activity	PIK3C2B PI4KA PI4K2A DGKH	1.35e-05	41	71	4	GO:0001727
GeneOntologyMolecularFunction	1-phosphatidylinositol 4-kinase activity	PI4KA PI4K2A	7.44e-05	4	71	2	GO:0004430
GeneOntologyMolecularFunction	phosphatidylinositol kinase activity	PIK3C2B PI4KA PI4K2A	1.06e-04	26	71	3	GO:0052742
GeneOntologyMolecularFunction	testosterone 6-beta-hydroxylase activity	CYP3A7 CYP3A4	1.24e-04	5	71	2	GO:0050649
GeneOntologyMolecularFunction	estrogen 2-hydroxylase activity	CYP3A7 CYP3A4	3.44e-04	8	71	2	GO:0101021
GeneOntologyMolecularFunction	estrogen 16-alpha-hydroxylase activity	CYP3A7 CYP3A4	6.72e-04	11	71	2	GO:0101020
GeneOntologyMolecularFunction	ligase activity, forming carbon-nitrogen bonds	RIMKLB ASNS MTHFS	8.88e-04	53	71	3	GO:0016879
GeneOntologyBiologicalProcess	lipid modification	CYP3A7 CYP3A4 INPP5B B4GALNT2 DGKH ACOX3	7.45e-05	214	68	6	GO:0030258
GeneOntologyBiologicalProcess	glycerophospholipid biosynthetic process	LPIN1 PIK3C2B PI4KA AGPAT1 PI4K2A DGKH	8.04e-05	217	68	6	GO:0046474
GeneOntologyBiologicalProcess	glycerophospholipid metabolic process	LPIN1 PIK3C2B INPP5B PI4KA AGPAT1 PI4K2A DGKH	8.73e-05	320	68	7	GO:0006650
GeneOntologyBiologicalProcess	transposable element silencing by mRNA destabilization	TUT7 MOV10	1.06e-04	5	68	2	GO:0141008
GeneOntologyBiologicalProcess	carboxylic acid metabolic process	LPIN1 CYP3A7 RIMKLB CYP3A4 P4HA1 ASL ASNS ALDH1L1 MTHFS ELOVL6 ACOX3 FAAH2	1.29e-04	1035	68	12	GO:0019752
GeneOntologyBiologicalProcess	glutamine family amino acid metabolic process	RIMKLB ASL ASNS MTHFS	1.41e-04	80	68	4	GO:0009064
GeneOntologyBiologicalProcess	oxoacid metabolic process	LPIN1 CYP3A7 RIMKLB CYP3A4 P4HA1 ASL ASNS ALDH1L1 MTHFS ELOVL6 ACOX3 FAAH2	1.58e-04	1058	68	12	GO:0043436
GeneOntologyBiologicalProcess	retrograde neuronal dense core vesicle transport	KIF1A KIF1C	1.59e-04	6	68	2	GO:1990049
GeneOntologyBiologicalProcess	organic acid metabolic process	LPIN1 CYP3A7 RIMKLB CYP3A4 P4HA1 ASL ASNS ALDH1L1 MTHFS ELOVL6 ACOX3 FAAH2	1.67e-04	1064	68	12	GO:0006082
GeneOntologyBiologicalProcess	folic acid-containing compound catabolic process	ALDH1L1 MTHFS	2.23e-04	7	68	2	GO:0009397
GeneOntologyBiologicalProcess	pteridine-containing compound catabolic process	ALDH1L1 MTHFS	2.23e-04	7	68	2	GO:0042560
GeneOntologyBiologicalProcess	phosphatidic acid biosynthetic process	LPIN1 AGPAT1 DGKH	2.26e-04	36	68	3	GO:0006654
GeneOntologyBiologicalProcess	glycerolipid biosynthetic process	LPIN1 PIK3C2B PI4KA AGPAT1 PI4K2A DGKH	2.54e-04	268	68	6	GO:0045017
GeneOntologyBiologicalProcess	phospholipid biosynthetic process	LPIN1 PIK3C2B PI4KA AGPAT1 PI4K2A DGKH	2.54e-04	268	68	6	GO:0008654
GeneOntologyBiologicalProcess	aflatoxin metabolic process	CYP3A4 GSTA3	2.96e-04	8	68	2	GO:0046222
GeneOntologyBiologicalProcess	anterograde neuronal dense core vesicle transport	KIF1A KIF1C	2.96e-04	8	68	2	GO:1990048
GeneOntologyBiologicalProcess	mycotoxin metabolic process	CYP3A4 GSTA3	2.96e-04	8	68	2	GO:0043385
GeneOntologyBiologicalProcess	organic heteropentacyclic compound metabolic process	CYP3A4 GSTA3	2.96e-04	8	68	2	GO:1901376
GeneOntologyBiologicalProcess	cellular response to alkaloid	BLM CRHBP RYR3	3.10e-04	40	68	3	GO:0071312
GeneOntologyBiologicalProcess	lipid biosynthetic process	LPIN1 CYP3A7 MBTPS1 PIK3C2B CYP3A4 PI4KA AGPAT1 PI4K2A DGKH ELOVL6	3.14e-04	813	68	10	GO:0008610
GeneOntologyBiologicalProcess	phosphatidic acid metabolic process	LPIN1 AGPAT1 DGKH	3.34e-04	41	68	3	GO:0046473
GeneOntologyBiologicalProcess	lipid hydroxylation	CYP3A7 CYP3A4	3.80e-04	9	68	2	GO:0002933
GeneOntologyBiologicalProcess	phospholipid metabolic process	LPIN1 PIK3C2B INPP5B PI4KA AGPAT1 PI4K2A DGKH	3.98e-04	410	68	7	GO:0006644
GeneOntologyBiologicalProcess	glycerolipid metabolic process	LPIN1 PIK3C2B INPP5B PI4KA AGPAT1 PI4K2A DGKH	5.21e-04	429	68	7	GO:0046486
GeneOntologyBiologicalProcess	L-amino acid metabolic process	RIMKLB P4HA1 ASL ASNS MTHFS	6.19e-04	208	68	5	GO:0170033
GeneOntologyBiologicalProcess	oxidative demethylation	CYP3A7 CYP3A4	6.92e-04	12	68	2	GO:0070989
GeneOntologyBiologicalProcess	dense core granule cytoskeletal transport	KIF1A KIF1C	6.92e-04	12	68	2	GO:0099519
GeneOntologyBiologicalProcess	spliceosomal snRNP assembly	SNRPGP15 SNRPG AAR2	7.54e-04	54	68	3	GO:0000387
GeneOntologyBiologicalProcess	modified amino acid metabolic process	P4HA1 ASL ALDH1L1 MTHFS GSTA3	7.65e-04	218	68	5	GO:0006575
GeneOntologyBiologicalProcess	amino acid metabolic process	RIMKLB SARS2 P4HA1 ASL ASNS MTHFS	7.87e-04	332	68	6	GO:0006520
GeneOntologyBiologicalProcess	cellular response to xenobiotic stimulus	BLM CYP3A7 CYP3A4 CRHBP GSTA3	8.30e-04	222	68	5	GO:0071466
GeneOntologyBiologicalProcess	dense core granule transport	KIF1A KIF1C	9.50e-04	14	68	2	GO:1901950
GeneOntologyCellularComponent	U5 snRNP	SNRPGP15 SNRPG AAR2	8.18e-05	25	71	3	GO:0005682
GeneOntologyCellularComponent	pole plasm	SNRPGP15 SNRPG MOV10	1.29e-04	29	71	3	GO:0045495
GeneOntologyCellularComponent	germ plasm	SNRPGP15 SNRPG MOV10	1.29e-04	29	71	3	GO:0060293
GeneOntologyCellularComponent	P granule	SNRPGP15 SNRPG MOV10	1.29e-04	29	71	3	GO:0043186
GeneOntologyCellularComponent	U4 snRNP	SNRPGP15 SNRPG	8.66e-04	13	71	2	GO:0005687
Domain	DNase_TatD-rel_CS	TATDN2 TATDN1	1.38e-05	2	70	2	IPR018228
Domain	PI3/4_kinase_cat_dom	PIK3C2B PI4KA PI4K2A	3.95e-05	18	70	3	IPR000403
Domain	PI3_PI4_kinase	PIK3C2B PI4KA PI4K2A	3.95e-05	18	70	3	PF00454
Domain	PI3_4_KINASE_3	PIK3C2B PI4KA PI4K2A	3.95e-05	18	70	3	PS50290
Domain	PI3_4_KINASE_1	PIK3C2B PI4KA PI4K2A	3.95e-05	18	70	3	PS00915
Domain	PI3_4_KINASE_2	PIK3C2B PI4KA PI4K2A	3.95e-05	18	70	3	PS00916
Domain	TatD_DNase	TATDN2 TATDN1	4.14e-05	3	70	2	PF01026
Domain	TATD_2	TATDN2 TATDN1	4.14e-05	3	70	2	PS01090
Domain	TATD_3	TATDN2 TATDN1	4.14e-05	3	70	2	PS01091
Domain	TatD_family	TATDN2 TATDN1	4.14e-05	3	70	2	IPR001130
Domain	Cyt_P450_E_grp-II	CYP3A7 CYP3A4	1.37e-04	5	70	2	IPR002402
Domain	Cyt_P450_E_CYP3A	CYP3A7 CYP3A4	2.06e-04	6	70	2	IPR008072
Domain	Kinesin_assoc	KIF1A KIF1C	2.06e-04	6	70	2	PF16183
Domain	Kinesin_assoc	KIF1A KIF1C	2.06e-04	6	70	2	IPR032405
Domain	PI3Ka	PIK3C2B PI4KA	4.90e-04	9	70	2	PF00613
Domain	-	PIK3C2B PI4KA	4.90e-04	9	70	2	1.25.40.70
Domain	PI3Ka	PIK3C2B PI4KA	4.90e-04	9	70	2	SM00145
Domain	PIK_HELICAL	PIK3C2B PI4KA	6.11e-04	10	70	2	PS51545
Domain	PI_Kinase	PIK3C2B PI4KA	6.11e-04	10	70	2	IPR015433
Domain	PInositide-3_kin_accessory_dom	PIK3C2B PI4KA	6.11e-04	10	70	2	IPR001263
Domain	SAM/pointed	ANKS6 ERG DGKH TFCP2	9.75e-04	117	70	4	IPR013761
Domain	PI3/4_kinase_CS	PIK3C2B PI4KA	1.41e-03	15	70	2	IPR018936
Domain	-	PIK3C2B PI4KA	1.61e-03	16	70	2	1.10.1070.11
Domain	PI3Kc	PIK3C2B PI4KA	1.61e-03	16	70	2	SM00146
Domain	Metal_Hydrolase	TATDN2 TATDN1	3.62e-03	24	70	2	IPR032466
Domain	Cys-rich_flank_reg_C	LRIG3 LRRC24 LRIT1	4.69e-03	90	70	3	IPR000483
Domain	LRRCT	LRIG3 LRRC24 LRIT1	4.69e-03	90	70	3	SM00082
Domain	FHA	KIF1A KIF1C	4.91e-03	28	70	2	SM00240
Domain	Ig_I-set	LRIG3 MYOM1 LRRC24 LRIT1	5.64e-03	190	70	4	IPR013098
Domain	I-set	LRIG3 MYOM1 LRRC24 LRIT1	5.64e-03	190	70	4	PF07679
Domain	LRRNT	LRIG3 LRRC24 LRIT1	5.95e-03	98	70	3	IPR000372
Domain	LRRNT	LRIG3 LRRC24 LRIT1	5.95e-03	98	70	3	SM00013
Domain	FHA_DOMAIN	KIF1A KIF1C	6.00e-03	31	70	2	PS50006
Domain	FHA	KIF1A KIF1C	6.00e-03	31	70	2	PF00498
Domain	LRRCT	LRIG3 LRRC24	6.39e-03	32	70	2	PF01463
Domain	-	ANKS6 ERG DGKH	7.38e-03	106	70	3	1.10.150.50
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	BLM DNAH12 COL6A6 PIK3C2B P4HA1 USP9X ALDH1L1 HYDIN RGS12 RYR3	7.88e-08	497	72	10	36774506
Pubmed	The crystal structure of the phosphatidylinositol 4-kinase IIα.	PI4KA PI4K2A	4.23e-06	2	72	2	25168678
Pubmed	Digging Deeper into CYP3A Testosterone Metabolism: Kinetic, Regioselectivity, and Stereoselectivity Differences between CYP3A4/5 and CYP3A7.	CYP3A7 CYP3A4	4.23e-06	2	72	2	28986474
Pubmed	Differential regulation of CYP3A4 and CYP3A7 by dimethylsulfoxide in primary human hepatocytes.	CYP3A7 CYP3A4	4.23e-06	2	72	2	15379787
Pubmed	Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.	CYP3A7 CYP3A4	4.23e-06	2	72	2	26772622
Pubmed	Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny.	CYP3A7 CYP3A4	4.23e-06	2	72	2	26921389
Pubmed	Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.	CYP3A7 CYP3A4	4.23e-06	2	72	2	11940601
Pubmed	Expression of CYP3A4 and CYP3A7 in Human Foetal Tissues and its Correlation with Nuclear Receptors.	CYP3A7 CYP3A4	4.23e-06	2	72	2	25689036
Pubmed	Immunohistochemical markers of CYP3A4 and CYP3A7: a new tool towards personalized pharmacotherapy of hepatocellular carcinoma.	CYP3A7 CYP3A4	4.23e-06	2	72	2	27349315
Pubmed	Developmental regulation of CYP3A4 and CYP3A7 in Chinese Han population.	CYP3A7 CYP3A4	4.23e-06	2	72	2	27727071
Pubmed	Expression and cyclic variability of CYP3A4 and CYP3A7 isoforms in human endometrium and cervix during the menstrual cycle.	CYP3A7 CYP3A4	4.23e-06	2	72	2	12485945
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	GPHN LRIG3 ANKS6 LAMTOR4 TAPT1 KIF1A PI4KA PI4K2A	9.77e-06	504	72	8	34432599
Pubmed	Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s.	TUT7 MOV10	1.27e-05	3	72	2	30122351
Pubmed	The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test.	CYP3A7 CYP3A4	1.27e-05	3	72	2	19801957
Pubmed	Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes.	CYP3A7 CYP3A4	1.27e-05	3	72	2	23143891
Pubmed	Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template.	CYP3A7 CYP3A4	1.27e-05	3	72	2	33866277
Pubmed	Cytochrome P450 3A gene variation, steroid hormone serum levels and prostate cancer--The Rotterdam Study.	CYP3A7 CYP3A4	1.27e-05	3	72	2	20621111
Pubmed	Contribution of three CYP3A isoforms to metabolism of R- and S-warfarin.	CYP3A7 CYP3A4	1.27e-05	3	72	2	20615193
Pubmed	Effects of hypoxia-inducible factor-1α chemical stabilizer, CoCl(2) and hypoxia on gene expression of CYP3As in human fetal liver cells.	CYP3A7 CYP3A4	1.27e-05	3	72	2	22277676
Pubmed	Comparison of steroid hormone hydroxylation mediated by cytochrome P450 3A subfamilies.	CYP3A7 CYP3A4	1.27e-05	3	72	2	32001245
Pubmed	CYP3A Polymorphism and Chronic Mercury Intoxication.	CYP3A7 CYP3A4	1.27e-05	3	72	2	32146629
Pubmed	In vivo optical trapping indicates kinesin's stall force is reduced by dynein during intracellular transport.	KIF1A KIF1C	1.27e-05	3	72	2	23404705
Pubmed	Loss of phosphatidylinositol 4-kinase 2alpha activity causes late onset degeneration of spinal cord axons.	PI4KA PI4K2A	1.27e-05	3	72	2	19581584
Pubmed	Differences in CYP3A41G genotype distribution and haplotypes of CYP3A4, CYP3A5 and CYP3A7 in 3 Chinese populations.	CYP3A7 CYP3A4	1.27e-05	3	72	2	17582393
Pubmed	Cytochrome P450 3As gene expression and testosterone 6 beta-hydroxylase activity in human fetal membranes and placenta at full term.	CYP3A7 CYP3A4	1.27e-05	3	72	2	20118548
Pubmed	CYP3A7, CYP3A4, and CYP3A5 genetic polymorphisms in recipients rather than donors influence tacrolimus concentrations in the early stages after liver transplantation.	CYP3A7 CYP3A4	1.27e-05	3	72	2	34688813
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	ZSWIM8 RIMKLB SARS2 ERG ASL AGPAT1 CTDP1 SMARCD3 LONRF3 POLK	2.04e-05	925	72	10	28986522
Pubmed	Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover.	PI4KA PI4K2A	2.53e-05	4	72	2	12594831
Pubmed	Distinct plasma-membrane PtdIns(4)P and PtdIns(4,5)P2 dynamics in secretagogue-stimulated beta-cells.	PI4KA PI4K2A	2.53e-05	4	72	2	20375060
Pubmed	Histopathology of melanosis coli and determination of its associated genes by comparative analysis of expression microarrays.	CYP3A7 CYP3A4	2.53e-05	4	72	2	26238215
Pubmed	USP9X deubiquitylating enzyme maintains RAPTOR protein levels, mTORC1 signalling and proliferation in neural progenitors.	USP9X RPS6	2.53e-05	4	72	2	28341829
Pubmed	Allele and genotype frequencies of CYP3A4, CYP3A5, CYP3A7, and GSTP1 gene polymorphisms among mainland Tibetan, Mongolian, Uyghur, and Han Chinese populations.	CYP3A7 CYP3A4	2.53e-05	4	72	2	34689350
Pubmed	CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients.	CYP3A7 CYP3A4	2.53e-05	4	72	2	18978522
Pubmed	Biosynthesis of triacylglycerols.	LPIN1 AGPAT1 ELOVL6	2.69e-05	28	72	3	8944226
Pubmed	Cytochrome P450 isoforms are differently up-regulated in aflatoxin B₁-exposed human lymphocytes and monocytes.	CYP3A7 CYP3A4	4.21e-05	5	72	2	24168324
Pubmed	Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol.	CYP3A7 CYP3A4	4.21e-05	5	72	2	14559847
Pubmed	Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.	CYP3A7 CYP3A4	4.21e-05	5	72	2	11266076
Pubmed	Stabilization of phosphatidylinositol 4-kinase type IIbeta by interaction with Hsp90.	PI4KA PI4K2A	4.21e-05	5	72	2	21330372
Pubmed	Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.	CYP3A7 CYP3A4	4.21e-05	5	72	2	11093772
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	RIMKLB LAMTOR4 PIK3C2B TATDN2 B4GALNT2 SMARCD3 DGKH COL25A1 TATDN1 KIF1C	4.69e-05	1021	72	10	26760575
Pubmed	Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.	LRIG3 LRRC24 LRIT1	4.86e-05	34	72	3	18848646
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	BLM ZSWIM8 KIF1A USP9X RPS6 TUT7 ASNS MOV10	6.16e-05	653	72	8	22586326
Pubmed	The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons.	CYP3A7 CYP3A4	8.82e-05	7	72	2	11137287
Pubmed	Association between ABCC2 polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients.	CYP3A7 CYP3A4	8.82e-05	7	72	2	19842932
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	BLM FBXL18 PI4KA RPS6 TAF1B TUT7 ASNS ADNP2 MTHFS MOV10 AAR2	1.01e-04	1353	72	11	29467282
Pubmed	A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir.	CYP3A7 CYP3A4	1.17e-04	8	72	2	20147896
Pubmed	HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.	KIF1A KIF1C	1.17e-04	8	72	2	25818806
Pubmed	Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER case-control study.	ALDH1L1 MTHFS	1.51e-04	9	72	2	17119116
Pubmed	One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia.	ALDH1L1 MTHFS	1.88e-04	10	72	2	17891500
Pubmed	USP9X-mediated NRP1 deubiquitination promotes liver fibrosis by activating hepatic stellate cells.	USP9X ALDH1L1	1.88e-04	10	72	2	36653359
Pubmed	Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.	CYP3A7 CYP3A4	1.88e-04	10	72	2	12865317
Pubmed	Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1.	TTBK2 USP9X PI4KA	2.42e-04	58	72	3	31067491
Pubmed	CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes.	CYP3A7 CYP3A4	2.75e-04	12	72	2	15319333
Pubmed	Sequence diversity and haplotype structure at the human CYP3A cluster.	CYP3A7 CYP3A4	3.25e-04	13	72	2	16314882
Pubmed	Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer.	ALDH1L1 MTHFS	3.25e-04	13	72	2	19936946
Pubmed	The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.	ERG USP9X	3.78e-04	14	72	2	27626314
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	USP9X COA1 SNRPG AAR2 KIF1C	4.03e-04	300	72	5	28561026
Pubmed	Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility.	GPHN RPS6	4.36e-04	15	72	2	32853550
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	LPIN1 ZSWIM8 USP9X PI4KA AAR2	4.89e-04	313	72	5	38270169
Pubmed	CHIP E3 ligase mediates proteasomal degradation of the proliferation regulatory protein ALDH1L1 during the transition of NIH3T3 fibroblasts from G0/G1 to S-phase.	USP9X ALDH1L1	4.98e-04	16	72	2	29979702
Pubmed	Targeting USP9X-AMPK Axis in ARID1A-Deficient Hepatocellular Carcinoma.	USP9X SMARCD3	4.98e-04	16	72	2	35390516
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	TTBK2 TAPT1 PI4K2A DGKH LBP COL25A1 HYDIN	5.47e-04	686	72	7	29987050
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	LPIN1 P4HA1 RPS6 ADNP2 ITPRIP COL25A1 TFCP2	5.61e-04	689	72	7	36543142
Pubmed	Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J intercross and a combined intercross involving NZB/B1NJ, RF/J, MRL/MpJ, and SJL/J mouse strains.	LPIN1 PI4K2A	5.63e-04	17	72	2	17496333
Pubmed	Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women.	CYP3A7 CYP3A4	5.63e-04	17	72	2	19424794
Pubmed	Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease.	ERG MYOM1	5.63e-04	17	72	2	29371594
Pubmed	Interferon regulatory factor 8 (IRF8) interacts with the B cell lymphoma 6 (BCL6) corepressor BCOR.	FBXL18 POLK	5.63e-04	17	72	2	25331958
Pubmed	Defining the membrane proteome of NK cells.	P4HA1 USP9X PI4KA RPS6 AGPAT1 PI4K2A ITPRIP RPL3L ACOX3	6.72e-04	1168	72	9	19946888
Pubmed	A comprehensive resource of interacting protein regions for refining human transcription factor networks.	KIF1A LONRF3 TFCP2 RYR3	6.77e-04	191	72	4	20195357
Pubmed	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	CYP3A7 CYP3A4 ALDH1L1 GSTA3	7.04e-04	193	72	4	19343046
Pubmed	Molecular genetics of the human cytochrome P450 monooxygenase superfamily.	CYP3A7 CYP3A4	7.84e-04	20	72	2	9890157
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	LPIN1 ZSWIM8 ADNP2	7.96e-04	87	72	3	12465718
Pubmed	Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.	PIK3C2B TAF1B AGPAT1 B4GALNT2	8.19e-04	201	72	4	23535732
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	SNRPGP15 ZSWIM8 KIF1A USP9X ITPRIP ZNF44	1.00e-03	552	72	6	10737800
Pubmed	Genome-wide association study of chronic periodontitis in a general German population.	LBP MTHFS RYR3	1.06e-03	96	72	3	24024966
Pubmed	Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver.	ALDH1L1 MTHFS	1.13e-03	24	72	2	17937387
Pubmed	Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TTBK2 ZSWIM8 ADNP2	1.19e-03	100	72	3	10048485
Pubmed	Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.	KIF1A KIF1C	1.23e-03	25	72	2	9275178
Pubmed	siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.	BLM POLK	1.33e-03	26	72	2	23435420
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	LPIN1 ZSWIM8 ANKS6 RIMKLB PIK3C2B USP9X RPS6 TFCP2	1.36e-03	1038	72	8	26673895
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	BLM ZSWIM8 PIK3C2B USP9X PI4KA POLK	1.38e-03	588	72	6	38580884
Pubmed	C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.	RPS6 RPL3L	1.43e-03	27	72	2	29420262
Pubmed	Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.	USP9X CD163L1 RPS6 TUT7 RPL3L	1.64e-03	411	72	5	36652389
Pubmed	Integrating genetic and network analysis to characterize genes related to mouse weight.	PI4K2A DGKH	1.65e-03	29	72	2	16934000
Pubmed	Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study.	ALDH1L1 MTHFS	1.65e-03	29	72	2	19048631
Pubmed	TopBP1 controls BLM protein level to maintain genome stability.	BLM USP9X	1.65e-03	29	72	2	24239288
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	SNRPGP15 ZSWIM8 SARS2 USP9X RPS6 ASNS TFCP2 MOV10 AAR2	1.71e-03	1335	72	9	29229926
Pubmed	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	ZSWIM8 P4HA1 PI4K2A ITPRIP LRIT1	1.72e-03	415	72	5	16385451
Pubmed	Large-scale identification of human genes implicated in epidermal barrier function.	LAMTOR4 ITPRIP	1.77e-03	30	72	2	17562024
Pubmed	Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.	CYP3A7 CYP3A4	1.77e-03	30	72	2	20529763
Pubmed	USP7 Regulates Cytokinesis through FBXO38 and KIF20B.	BLM ADNP2 POLK	1.82e-03	116	72	3	30804394
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ANKS6 SARS2 SLC16A5 LRRC24 PIK3C2B PI4KA CTDP1 ACOX3	2.01e-03	1105	72	8	35748872
Interaction	FBXO22 interactions	BLM DNAH12 COL6A6 PIK3C2B P4HA1 USP9X ALDH1L1 HYDIN RGS12 RYR3 AAR2	2.06e-06	540	69	11	int:FBXO22
GeneFamily	Cytochrome P450 family 3	CYP3A7 CYP3A4	1.91e-04	8	48	2	1002
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	LRIG3 MYOM1 LRRC24 LRIT1	8.69e-04	161	48	4	593
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LPIN1 ASL ALDH1L1 ELOVL6 GSTA3	5.80e-06	158	72	5	9f58428f70d1427b20122c5c1cc7bf521d0f4832
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBXN11 CD163L1 ITPRIP LBP RYR3	1.25e-05	185	72	5	bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ERG PIK3C2B ITPRIP CRHBP RYR3	1.42e-05	190	72	5	656483751e4bf137e4e4bfb2a03a478a8f7fcb63
ToppCell	background-Endothelial_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	RIMKLB ERG CYP3A4 ITPRIP CRHBP	1.61e-05	195	72	5	c7d60dabfc7cb310e002cab10003dadfcc34fe33
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ERG PIK3C2B ITPRIP CRHBP RYR3	1.65e-05	196	72	5	22767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ERG PIK3C2B ITPRIP CRHBP RYR3	1.65e-05	196	72	5	adee900dcd16dbaba15c58bdcace09ba20214950
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ERG PIK3C2B ITPRIP CRHBP RYR3	1.73e-05	198	72	5	07701c73137947ed4a27e225975329235bbb8734
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ERG PIK3C2B ITPRIP CRHBP RYR3	1.73e-05	198	72	5	fa84bf8533d1b91d2c2bcf06b710670605072b89
Disease	tacrolimus measurement	CYP3A7 CYP3A4	3.22e-05	4	69	2	EFO_0008458
Disease	estrone conjugate measurement	CYP3A7 CYP3A4	3.22e-05	4	69	2	EFO_0007971
Disease	tauro-beta-muricholate measurement	CYP3A7 CYP3A4	5.36e-05	5	69	2	EFO_0800213
Disease	glyco-beta-muricholate measurement	CYP3A7 CYP3A4	5.36e-05	5	69	2	EFO_0800569
Disease	dehydroisoandrosterone sulfate DHEA-S measurement	CYP3A7 CYP3A4	8.03e-05	6	69	2	EFO_0021119
Disease	androstenediol (3beta,17beta) monosulfate (1) measurement	CYP3A7 CYP3A4	8.03e-05	6	69	2	EFO_0800294
Disease	X-24574 measurement	CYP3A7 CYP3A4	1.12e-04	7	69	2	EFO_0800897
Disease	androstenediol (3beta,17beta) disulfate (1) measurement	CYP3A7 CYP3A4	1.92e-04	9	69	2	EFO_0800278
Disease	4-androsten-3alpha,17alpha-diol monosulfate (3) measurement	CYP3A7 CYP3A4	2.40e-04	10	69	2	EFO_0022090
Disease	5alpha-androstan-3beta,17alpha-diol disulfate measurement	CYP3A7 CYP3A4	2.40e-04	10	69	2	EFO_0800289
Disease	DNA repair protein RAD51 homolog 4 measurement	CYP3A7 CYP3A4	2.92e-04	11	69	2	EFO_0801531
Disease	androstenediol (3beta,17beta) monosulfate (2) measurement	CYP3A7 CYP3A4	2.92e-04	11	69	2	EFO_0800295
Disease	nervous system disease (implicated_via_orthology)	KIF1A KIF1C	3.50e-04	12	69	2	DOID:863 (implicated_via_orthology)
Disease	5alpha-androstan-3beta,17beta-diol monosulfate (2) measurement	CYP3A7 CYP3A4	3.50e-04	12	69	2	EFO_0800291
Disease	androstenediol (3alpha, 17alpha) monosulfate (3) measurement	CYP3A7 CYP3A4	4.13e-04	13	69	2	EFO_0800293
Disease	5alpha-pregnan-3beta,20beta-diol monosulfate (1) measurement	CYP3A7 CYP3A4	4.13e-04	13	69	2	EFO_0800284
Disease	X-21470 measurement	CYP3A7 CYP3A4	4.82e-04	14	69	2	EFO_0800817
Disease	5alpha-androstan-3alpha,17alpha-diol monosulfate measurement	CYP3A7 CYP3A4	4.82e-04	14	69	2	EFO_0800283
Disease	16a-hydroxy DHEA 3-sulfate measurement	CYP3A7 CYP3A4	5.55e-04	15	69	2	EFO_0800301
Disease	X-21410 measurement	CYP3A7 CYP3A4	6.33e-04	16	69	2	EFO_0800813
Disease	andro steroid monosulfate C19H28O6S (1) measurement	CYP3A7 CYP3A4	6.33e-04	16	69	2	EFO_0800305
Disease	5alpha-androstan-3alpha,17beta-diol monosulfate (1) measurement	CYP3A7 CYP3A4	8.05e-04	18	69	2	EFO_0800288
Disease	metabolonic lactone sulfate measurement	CYP3A7 CYP3A4	8.98e-04	19	69	2	EFO_0800659
Disease	etiocholanolone glucuronide measurement	CYP3A7 CYP3A4	8.98e-04	19	69	2	EFO_0800362
Disease	androsterone glucuronide measurement	CYP3A7 CYP3A4	9.96e-04	20	69	2	EFO_0800317
Disease	X-24947 measurement	CYP3A7 CYP3A4	1.21e-03	22	69	2	EFO_0800910
Disease	5alpha-androstan-3beta,17beta-diol disulfate measurement	CYP3A7 CYP3A4	1.21e-03	22	69	2	EFO_0021115
Disease	epiandrosterone sulfate measurement	CYP3A7 CYP3A4	1.56e-03	25	69	2	EFO_0021120
Disease	Epileptic encephalopathy	GPHN RYR3	2.25e-03	30	69	2	C0543888

Protein segments in the cluster

Peptide	Gene	Start	Entry
GFHRLAVVDPLFGMQ	ASNS	46	P08243
NKGIFHFQLGRGEPM	CTDP1	206	Q9Y5B0
PDGHTFMQAGFRKAI	ANTXRL	146	A6NF34
LDNGFAMFHKVRVPR	ACOX3	256	O15254
NGACLHKRMGFFQPL	B4GALNT2	446	Q8NHY0
PRLMHARNTGGAAFI	ERG	216	P11308
VGPRMGFFLSLHQRG	AAR2	71	Q9Y312
AMFRFGQAVTRHGKI	CD163L1	96	Q9NR16
QPKVVGRHFRMFHAP	ADNP2	116	Q6IQ32
GRHFRMFHAPVRKVQ	ADNP2	121	Q6IQ32
HFFIGNRKVPEAMGL	ITPRIP	476	Q8IWB1
HAQIHFGRVFMKPGL	GPHN	591	Q9NQX3
LIFMPGLGFDKHGNR	MTHFS	131	P49914
MFKGEIFHRNHRSPV	LBP	246	P18428
RRLPGVNMFEQGHGK	MBTPS1	451	Q14703
SFMGTFGKALRRPHL	LRIG3	1036	Q6UXM1
GMPFRQAHEASGKAV	ASL	381	P04424
VFTNRRPFGPVGFMK	CYP3A4	101	P08684
KLHYFNGRGRMEPIR	GSTA3	6	Q16772
QGPRMVFPKINHGFL	COL25A1	161	Q9BXS0
VRHGFMLVGEPFAAK	DNAH12	1526	Q6ZR08
GHVQAGIFKPRFAMR	PINLYP	156	A6NC86
KGSMNRHVAAIGPRF	PI4KA	1336	P42356
RIVMGKNHVFRFNHP	KIF1C	586	O43896
RGHEMFVINRSKPLF	LRRC24	466	Q50LG9
GNLQCSPFHVRFGKM	LPIN1	41	Q14693
SPFHVRFGKMGVLRS	LPIN1	46	Q14693
MNGGPHLGLRLFQKF	DGKH	366	Q86XP1
FGQHSMRRVIVQPGK	LRIT1	466	Q9P2V4
RFLGHAQMFGNIKRD	PIK3C2B	1216	O00750
FDRGQFHKQIAVMRG	PI4K2A	411	Q9BTU6
GFVGHPVNAFKLMKR	P4HA1	76	P13674
AAFIFGGRHLMNKRA	ELOVL6	41	Q9H5J4
RIKGEGMGPKIHFNF	HYDIN	451	Q4G0P3
GMRNIKHVGPSGRFT	BLM	1096	P54132
VAMIFFRVHEPGNGF	CRHBP	156	P24387
KRRPDIFHALKMGNF	ANKS6	291	Q68DC2
IRMPAFFNGIFGHKP	FAAH2	231	Q6GMR7
CGFRLHRGMNVPFKR	LAMTOR4	51	Q0VGL1
HRGMNVPFKRLSVVF	LAMTOR4	56	Q0VGL1
RMGNKGGVAIRFQFH	INPP5B	456	P32019
VFTNRRPFGPVGFMK	CYP3A7	101	P24462
RSMPLGARILFHGVF	COA1	11	Q9GZY4
ATVVQGFPMFKRGRC	CXCL11	16	O14625
GRSPMLNHLRKNFGF	COL6A6	86	A6NMZ7
GNRIIMGKSHVFRFN	KIF1A	581	Q12756
NKARAPAFSMGIRHS	ODF3L2	251	Q3SX64
ARVLHMVGDKPVFSF	SARS2	186	Q9NP81
MPFVKGLENRHNYGR	SPATA48	41	A4D263
PMSRAFRGKHLSFVV	USP9X	876	Q93008
FPMKQGVLTHGRVRL	RPS6	61	P62753
PMFRGIYRGVQKHQD	TATDN1	16	Q6P1N9
QALRHPKAVAFGEMG	TATDN2	581	Q93075
RQGFPIIFHGVMGKD	MOV10	771	Q9HCE1
HGRFQTAQEKRAFMG	RPL3L	376	Q92901
HFPEQMKLYGRDRGI	TAF1B	251	Q53T94
MHAVPRGFGKKVRVG	FBXL18	441	Q96ME1
SKLFEFLVHGVRPGM	SMARCD3	16	Q6STE5
AALRPMGHFTVLGKA	PNMA6A	41	P0CW24
RTVRMPHQLFIGGEF	ALDH1L1	416	O75891
AFGMQSIFGPHRNVR	RGS12	606	O14924
AGLMAGRPAFASHRK	SLC16A5	291	O15375
HVQGILRGFDPFMNL	SNRPG	26	P62308
FTMRKHGGEKGVPFR	TFCP2	196	Q12800
RNHNGSMLPFKRGAF	AGPAT1	181	Q99943
FSAGVKVRFLMGGRH	RYR3	781	Q15413
HVQGILRGFDPFMNL	SNRPGP15	26	A8MWD9
GFLHRDIKPSNFAMG	TTBK2	136	Q6IQ55
FGVRAAMPGFIAKRL	POLK	146	Q9UBT6
LEFPMVVKNTRGHRG	RIMKLB	151	Q9ULI2
FRMRAVKDPLQIGFH	ZSWIM8	141	A7E2V4
RKRAHIGVIPHFFMA	TAPT1	231	Q6NXT6
MKAFINGRRVFGIPV	TUT7	1301	Q5VYS8
FSSPGNLRRHMVVKG	ZNF44	226	P15621
FPGEGRVVGRQLMHK	UBXN11	301	Q5T124
LRPMGFKAHFRKAQA	LONRF3	306	Q496Y0
IFRVRAVNKMGIGFP	MYOM1	581	P52179