Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-9 ERVK-24	3.72e-14	37	51	8	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-9 ERVK-24	4.70e-14	38	51	8	GO:0070001
GeneOntologyMolecularFunction	transition metal ion binding	ERVK-6 RAG1 TRIM67 CYP2D7 DRP2 CYP2D6 FN1 GALT DTNA ERVK-8 ERVK-19 NR1H3 ERVK-7 ERVK-21 ERVK-9 ERVK-24	2.23e-08	1189	51	16	GO:0046914
GeneOntologyMolecularFunction	zinc ion binding	ERVK-6 RAG1 TRIM67 DRP2 GALT DTNA ERVK-8 ERVK-19 NR1H3 ERVK-7 ERVK-21 ERVK-9 ERVK-24	2.51e-07	891	51	13	GO:0008270
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-6 HGF ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-9 ERVK-24	1.25e-06	430	51	9	GO:0004175
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-8 ERVK-7	2.55e-06	11	51	3	GO:0004523
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7	5.60e-06	14	51	3	GO:0003964
GeneOntologyMolecularFunction	structural molecule activity	ERVK-6 FN1 ERVK-8 DAG1 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-9 ERVK-24 MYBPC1	1.21e-05	891	51	11	GO:0005198
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-8 ERVK-7	2.02e-05	21	51	3	GO:0035613
GeneOntologyMolecularFunction	peptidase activity	ERVK-6 HGF ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-9 ERVK-24	3.65e-05	654	51	9	GO:0008233
GeneOntologyMolecularFunction	anandamide 8,9 epoxidase activity	CYP2D7 CYP2D6	3.82e-05	4	51	2	GO:0062187
GeneOntologyMolecularFunction	anandamide 11,12 epoxidase activity	CYP2D7 CYP2D6	3.82e-05	4	51	2	GO:0062188
GeneOntologyMolecularFunction	steroid 21-monooxygenase activity	CYP2D7 CYP2D6	3.82e-05	4	51	2	GO:0004509
GeneOntologyMolecularFunction	progesterone 21-hydroxylase activity	CYP2D7 CYP2D6	3.82e-05	4	51	2	GO:0106309
GeneOntologyMolecularFunction	anandamide 14,15 epoxidase activity	CYP2D7 CYP2D6	9.53e-05	6	51	2	GO:0062189
GeneOntologyMolecularFunction	anandamide epoxidase activity	CYP2D7 CYP2D6	9.53e-05	6	51	2	GO:0062186
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7	1.15e-04	37	51	3	GO:0016891
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 ERVK-8 ERVK-7	1.24e-04	38	51	3	GO:0034061
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-8 ERVK-7	2.21e-04	46	51	3	GO:0016893
GeneOntologyMolecularFunction	U3 snoRNA binding	DHX37 PRKDC	3.47e-04	11	51	2	GO:0034511
GeneOntologyMolecularFunction	endonuclease activity	ERVK-6 RAG1 ERVK-8 ERVK-7	4.01e-04	136	51	4	GO:0004519
GeneOntologyMolecularFunction	nucleotidyltransferase activity	ERVK-6 GALT ERVK-8 ERVK-7	6.11e-04	152	51	4	GO:0016779
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-6 ERVK-8 ERVK-7	1.08e-03	79	51	3	GO:0004521
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP2D7 CYP2D6	2.16e-03	27	51	2	GO:0008391
GeneOntologyMolecularFunction	nuclease activity	ERVK-6 RAG1 ERVK-8 ERVK-7	2.85e-03	231	51	4	GO:0004518
GeneOntologyMolecularFunction	steroid hydroxylase activity	CYP2D7 CYP2D6	3.41e-03	34	51	2	GO:0008395
GeneOntologyMolecularFunction	snoRNA binding	DHX37 PRKDC	3.41e-03	34	51	2	GO:0030515
GeneOntologyMolecularFunction	aromatase activity	CYP2D7 CYP2D6	3.61e-03	35	51	2	GO:0070330
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERVK-6 RAG1 ERVK-8 ERVK-7	4.46e-03	262	51	4	GO:0140097
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	CYP2D7 CYP2D6	4.69e-03	40	51	2	GO:0016709
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-6 ERVK-8 ERVK-7	5.07e-03	136	51	3	GO:0004540
GeneOntologyMolecularFunction	structural constituent of muscle	DAG1 MYBPC1	5.40e-03	43	51	2	GO:0008307
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP2D7 CYP2D6	6.97e-03	49	51	2	GO:0016712
GeneOntologyBiologicalProcess	viral process	ERVK-6 ERVK-8 DAG1 LARP1 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-24	1.80e-06	464	51	9	GO:0016032
GeneOntologyBiologicalProcess	cell-cell fusion	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	2.14e-06	85	51	5	GO:0140253
GeneOntologyBiologicalProcess	syncytium formation by plasma membrane fusion	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	2.14e-06	85	51	5	GO:0000768
GeneOntologyBiologicalProcess	syncytium formation	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	2.68e-06	89	51	5	GO:0006949
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-8 ERVK-7	4.00e-06	13	51	3	GO:0015074
GeneOntologyBiologicalProcess	serotonin biosynthetic process from tryptophan	CYP2D7 CYP2D6	1.80e-05	3	51	2	GO:0006587
GeneOntologyBiologicalProcess	serotonin biosynthetic process	CYP2D7 CYP2D6	1.66e-04	8	51	2	GO:0042427
GeneOntologyBiologicalProcess	DNA synthesis involved in DNA repair	ERVK-6 ERVK-8 ERVK-7	2.28e-04	48	51	3	GO:0000731
GeneOntologyBiologicalProcess	indole-containing compound biosynthetic process	CYP2D7 CYP2D6	2.66e-04	10	51	2	GO:0042435
GeneOntologyBiologicalProcess	primary amino compound biosynthetic process	CYP2D7 CYP2D6	2.66e-04	10	51	2	GO:1901162
GeneOntologyCellularComponent	glycoprotein complex	DTNA DAG1 GP1BA	2.85e-05	25	50	3	GO:0090665
GeneOntologyCellularComponent	KICSTOR complex	SZT2 KICS2	3.35e-05	4	50	2	GO:0140007
GeneOntologyCellularComponent	super elongation complex	AFF1 AFF4	8.36e-05	6	50	2	GO:0032783
Domain	TF_AF4/FMR2	AFF1 AFF4	2.95e-05	4	42	2	IPR007797
Domain	AF-4	AFF1 AFF4	2.95e-05	4	42	2	PF05110
Domain	EF-hand_dom_typ1	DRP2 DTNA	7.36e-05	6	42	2	IPR015153
Domain	EF-hand_dom_typ2	DRP2 DTNA	7.36e-05	6	42	2	IPR015154
Domain	EF-hand_2	DRP2 DTNA	7.36e-05	6	42	2	PF09068
Domain	EF-hand_3	DRP2 DTNA	7.36e-05	6	42	2	PF09069
Domain	ZZ	DRP2 DTNA	7.38e-04	18	42	2	PF00569
Domain	ZF_ZZ_2	DRP2 DTNA	7.38e-04	18	42	2	PS50135
Domain	ZF_ZZ_1	DRP2 DTNA	7.38e-04	18	42	2	PS01357
Domain	Znf_ZZ	DRP2 DTNA	8.24e-04	19	42	2	IPR000433
Domain	ZnF_ZZ	DRP2 DTNA	8.24e-04	19	42	2	SM00291
Domain	Kringle-like	HGF FN1	2.35e-03	32	42	2	IPR013806
Domain	EF-hand-dom_pair	EPS15L1 STIM2 DRP2 DTNA	3.86e-03	287	42	4	IPR011992
Domain	fn3	TRIM67 FN1 MYBPC1	5.74e-03	162	42	3	PF00041
Domain	FN3	TRIM67 FN1 MYBPC1	8.27e-03	185	42	3	SM00060
Domain	FN3	TRIM67 FN1 MYBPC1	1.01e-02	199	42	3	PS50853
Pathway	KEGG_MEDICUS_VARIANT_DELETED_DMD_TO_DYSTROPHIN_ASSOCIATED_PROTEIN_COMPLEX	DTNA DAG1	2.66e-04	10	35	2	M47575
Pathway	KEGG_MEDICUS_REFERENCE_V_D_J_RECOMBINATION	RAG1 PRKDC	3.89e-04	12	35	2	M47856
Pathway	REACTOME_CYP2E1_REACTIONS	CYP2D7 CYP2D6	3.89e-04	12	35	2	MM14847
Pathway	REACTOME_BIOSYNTHESIS_OF_MARESINS	CYP2D7 CYP2D6	3.89e-04	12	35	2	MM15616
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	GALT NCAN DAG1 MUC16	4.16e-04	143	35	4	M27275
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-9 ERVK-24	1.43e-12	94	52	8	21542922
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9	4.82e-12	12	52	5	14557543
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-19 ERVK-7 ERVK-21	2.22e-11	5	52	4	12629516
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7 ERVK-24	1.26e-08	4	52	3	10469592
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-21 ERVK-25 ERVK-9 ERVK-24	1.34e-08	18	52	4	18664271
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-6 ERVK-19 ERVK-9	6.28e-08	6	52	3	15063128
Pubmed	Contribution of the different modules in the utrophin carboxy-terminal region to the formation and regulation of the DAP complex.	DRP2 DTNA DAG1	6.28e-08	6	52	3	10767429
Pubmed	LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer.	RAG1 NR1H3 PRKDC	1.76e-07	8	52	3	29336888
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVK-6 ERVK-19 ERVK-21	3.75e-07	10	52	3	12970426
Pubmed	Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells.	CYP2D7 CYP2D6	2.19e-06	2	52	2	11032406
Pubmed	Cardiac apoptosis in severe relapsing fever borreliosis.	RAG1 PRKDC	2.19e-06	2	52	2	16239571
Pubmed	Distinct roles of two SEC scaffold proteins, AFF1 and AFF4, in regulating RNA polymerase II transcription elongation.	AFF1 AFF4	2.19e-06	2	52	2	37528066
Pubmed	Recombinase-activating gene 1-associated expression of the myelin basic protein 1-11-specific transgenic T-cell receptor in H-2b mice.	RAG1 PRKDC	2.19e-06	2	52	2	18752298
Pubmed	During the early prediabetic period in NOD mice, the pathogenic CD8(+) T-cell population comprises multiple antigenic specificities.	RAG1 PRKDC	2.19e-06	2	52	2	12498815
Pubmed	Development of functional B cells in a line of SCID mice with transgenes coding for anti-double-stranded DNA antibody.	RAG1 PRKDC	2.19e-06	2	52	2	16393973
Pubmed	Molecular evolution of the CYP2D subfamily in primates: purifying selection on substrate recognition sites without the frequent or long-tract gene conversion.	CYP2D7 CYP2D6	2.19e-06	2	52	2	25808902
Pubmed	Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism?	CYP2D7 CYP2D6	2.19e-06	2	52	2	11207030
Pubmed	Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.	ERVK-6 ERVK-19	2.19e-06	2	52	2	9060628
Pubmed	Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.	ERVK-6 ERVK-19	2.19e-06	2	52	2	9460924
Pubmed	AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter.	AFF1 AFF4	2.19e-06	2	52	2	24843025
Pubmed	Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.	CYP2D7 CYP2D6	2.19e-06	2	52	2	3123997
Pubmed	The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.	CYP2D7 CYP2D6	2.19e-06	2	52	2	19594327
Pubmed	Novel role of the Ras cascade in memory B cell response.	RAG1 PRKDC	2.19e-06	2	52	2	16111632
Pubmed	Coding-noncoding gene expression in intrahepatic cholangiocarcinoma.	CYP2D7 CYP2D6	2.19e-06	2	52	2	26297049
Pubmed	Novel antibody reagents for characterization of drug- and tumor microenvironment-induced changes in epithelial-mesenchymal transition and cancer stem cells.	HGF PRKDC	2.19e-06	2	52	2	29928062
Pubmed	The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination.	RAG1 PRKDC	2.19e-06	2	52	2	17296939
Pubmed	Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription.	AFF1 AFF4	2.19e-06	2	52	2	26007649
Pubmed	Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions.	RAG1 PRKDC	2.19e-06	2	52	2	14662857
Pubmed	A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.	CYP2D7 CYP2D6	2.19e-06	2	52	2	15051713
Pubmed	Destabilization of the dystrophin-glycoprotein complex without functional deficits in alpha-dystrobrevin null muscle.	DTNA DAG1	2.19e-06	2	52	2	18596960
Pubmed	Expression of a bcl-2 transgene reduces proliferation and slows turnover of developing B lymphocytes in vivo.	RAG1 PRKDC	2.19e-06	2	52	2	9278319
Pubmed	Effect of different Ig transgenes on B cell differentiation in scid mice.	RAG1 PRKDC	2.19e-06	2	52	2	9088976
Pubmed	An intrinsic BM hematopoietic niche occupancy defect of HSC in scid mice facilitates exogenous HSC engraftment.	RAG1 PRKDC	2.19e-06	2	52	2	22147896
Pubmed	Analysis of stromal cell secretomes reveals a critical role for stromal cell-derived hepatocyte growth factor and fibronectin in angiogenesis.	HGF FN1	2.19e-06	2	52	2	23288153
Pubmed	Fibronectin and Hepatocyte Growth Factor Produced by Lung Fibroblasts Augment Migration and Invasion of Malignant Pleural Mesothelioma Cells.	HGF FN1	2.19e-06	2	52	2	28476806
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	FN1 ACSBG1 DTNA NCAN KIAA1549 LARP1 NUMB	3.48e-06	430	52	7	32581705
Pubmed	A Hitchhiker's guide to humanized mice: new pathways to studying viral infections.	RAG1 PRKDC	6.57e-06	3	52	2	29446074
Pubmed	Preconditioning allows engraftment of mouse and human embryonic lung cells, enabling lung repair in mice.	RAG1 PRKDC	6.57e-06	3	52	2	26168294
Pubmed	The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.	CYP2D7 CYP2D6	6.57e-06	3	52	2	2574001
Pubmed	Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract.	RAG1 PRKDC	6.57e-06	3	52	2	16606667
Pubmed	Dense granule protein 3 of Toxoplasma gondii plays a crucial role in the capability of the tissue cysts of the parasite to persist in the presence of anti-cyst CD8+ T cells during the chronic stage of infection.	RAG1 PRKDC	6.57e-06	3	52	2	37868957
Pubmed	Type 1 interferons suppress accelerated osteoclastogenesis and prevent loss of bone mass during systemic inflammatory responses to Pneumocystis lung infection.	RAG1 PRKDC	6.57e-06	3	52	2	22626807
Pubmed	Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.	RAG1 PRKDC	6.57e-06	3	52	2	18785974
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-6 ERVK-19	6.57e-06	3	52	2	10516026
Pubmed	DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging.	RAG1 PRKDC	6.57e-06	3	52	2	28467930
Pubmed	Modulation of inflammasome-mediated pulmonary immune activation by type I IFNs protects bone marrow homeostasis during systemic responses to Pneumocystis lung infection.	RAG1 PRKDC	6.57e-06	3	52	2	23975863
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-9	6.57e-06	3	52	2	9971820
Pubmed	Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice.	RAG1 PRKDC	6.57e-06	3	52	2	17015713
Pubmed	NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer.	RAG1 PRKDC	6.57e-06	3	52	2	24798995
Pubmed	A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease.	RAG1 PRKDC	6.57e-06	3	52	2	23142821
Pubmed	Angioinhibitory action of NK4 involves impaired extracellular assembly of fibronectin mediated by perlecan-NK4 association.	HGF FN1	6.57e-06	3	52	2	19553700
Pubmed	Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2rγ null mice is enhanced by transgenic expression of membrane-bound human SCF.	RAG1 PRKDC	6.57e-06	3	52	2	22246028
Pubmed	T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells.	RAG1 STIM2	6.57e-06	3	52	2	21061435
Pubmed	Lymphocytes mediate TNF-alpha-induced endothelial cell adhesion molecule expression: studies on SCID and RAG-1 mutant mice.	RAG1 PRKDC	6.57e-06	3	52	2	9366433
Pubmed	Scarless skin repair in immunodeficient mice.	RAG1 PRKDC	6.57e-06	3	52	2	16808805
Pubmed	mt-Nd2(a) Modifies resistance against autoimmune type 1 diabetes in NOD mice at the level of the pancreatic β-cell.	RAG1 PRKDC	6.57e-06	3	52	2	20980458
Pubmed	Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers.	RAG1 PRKDC	6.57e-06	3	52	2	37909039
Pubmed	Resistance to skin tumorigenesis in DNAPK-deficient SCID mice is not due to immunodeficiency but results from hypersensitivity to TPA-induced apoptosis.	RAG1 PRKDC	6.57e-06	3	52	2	10545405
Pubmed	Cooperation between physiological defenses and immune resistance produces asymptomatic carriage of a lethal bacterial pathogen.	RAG1 PRKDC	6.57e-06	3	52	2	37352357
Pubmed	Interferon-gamma-mediated site-specific clearance of alphavirus from CNS neurons.	RAG1 PRKDC	6.57e-06	3	52	2	11452126
Pubmed	NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment.	RAG1 PRKDC	6.57e-06	3	52	2	14557749
Pubmed	Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans.	RAG1 PRKDC	6.57e-06	3	52	2	21576342
Pubmed	Identification of the primary gene defect at the cytochrome P450 CYP2D locus.	CYP2D7 CYP2D6	6.57e-06	3	52	2	1978251
Pubmed	AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23).	AFF1 AFF4	6.57e-06	3	52	2	10588740
Pubmed	A xenograft model of macrophage activation syndrome amenable to anti-CD33 and anti-IL-6R treatment.	RAG1 PRKDC	6.57e-06	3	52	2	27699249
Pubmed	Cutting edge: Ly49C/I⁻ neonatal NK cells predispose newborns to autoimmune ovarian disease induced by maternal autoantibody.	RAG1 PRKDC	1.31e-05	4	52	2	23960238
Pubmed	Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells.	RAG1 PRKDC	1.31e-05	4	52	2	10435582
Pubmed	Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4.	AFF1 AFF4	1.31e-05	4	52	2	25282333
Pubmed	Pre-B-cell leukemias in Btk/Slp65-deficient mice arise independently of ongoing V(D)J recombination activity.	RAG1 PRKDC	1.31e-05	4	52	2	21030983
Pubmed	B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites.	RAG1 PRKDC	1.31e-05	4	52	2	10684864
Pubmed	Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses.	RAG1 PRKDC	1.31e-05	4	52	2	19636062
Pubmed	Anti-CD20 antibody therapy and susceptibility to Pneumocystis pneumonia.	RAG1 PRKDC	1.31e-05	4	52	2	25733518
Pubmed	Induction of immortal-like and functional CAR T cells by defined factors.	RAG1 PRKDC	1.31e-05	4	52	2	38530240
Pubmed	A Minor Subset of Super Elongation Complexes Plays a Predominant Role in Reversing HIV-1 Latency.	AFF1 AFF4	1.31e-05	4	52	2	26830226
Pubmed	An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis.	RAG1 PRKDC	1.31e-05	4	52	2	30220458
Pubmed	Novel hepatocyte growth factor (HGF) binding domains on fibronectin and vitronectin coordinate a distinct and amplified Met-integrin induced signalling pathway in endothelial cells.	HGF FN1	1.31e-05	4	52	2	15717924
Pubmed	Fas (CD95/APO-1) limits the expansion of T lymphocytes in an environment of limited T-cell antigen receptor/MHC contacts.	RAG1 PRKDC	1.31e-05	4	52	2	21266499
Pubmed	Early thymocyte development is regulated by modulation of E2A protein activity.	RAG1 PRKDC	1.31e-05	4	52	2	11560990
Pubmed	Deranged early T cell development in immunodeficient strains of nonobese diabetic mice.	RAG1 PRKDC	1.31e-05	4	52	2	15494484
Pubmed	Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice.	RAG1 PRKDC	1.31e-05	4	52	2	15308121
Pubmed	GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma.	RAG1 PRKDC	1.31e-05	4	52	2	18402690
Pubmed	Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis.	RAG1 PRKDC	1.31e-05	4	52	2	22773809
Pubmed	Tlx acts as a proangiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes.	FN1 NR1H3	1.31e-05	4	52	2	16424942
Pubmed	Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels.	RAG1 STIM2	1.31e-05	4	52	2	30862784
Pubmed	Creation of "humanized" mice to study human immunity.	RAG1 PRKDC	1.31e-05	4	52	2	18491294
Pubmed	ICAM-1 controls development and function of ILC2.	RAG1 PRKDC	1.31e-05	4	52	2	30049704
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-19	1.31e-05	4	52	2	7983737
Pubmed	Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice.	AFF1 AFF4	1.31e-05	4	52	2	11923441
Pubmed	Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes.	RAG1 PRKDC	1.31e-05	4	52	2	20033053
Pubmed	PD-1-dependent restoration of self-tolerance in the NOD mouse model of diabetes after transient anti-TCRβ mAb therapy.	RAG1 PRKDC	1.31e-05	4	52	2	25794782
Pubmed	Mediation of Af4 protein function in the cerebellum by Siah proteins.	AFF1 AFF4	1.31e-05	4	52	2	15459319
Pubmed	Nfkbid Overexpression in Nonobese Diabetic Mice Elicits Complete Type 1 Diabetes Resistance in Part Associated with Enhanced Thymic Deletion of Pathogenic CD8 T Cells and Increased Numbers and Activity of Regulatory T Cells.	RAG1 PRKDC	1.31e-05	4	52	2	35760520
Pubmed	Nuclear localization of p38 MAPK in response to DNA damage.	RAG1 PRKDC	1.31e-05	4	52	2	19564926
Pubmed	Dopamine inhibits group 2 innate lymphoid cell-driven allergic lung inflammation by dampening mitochondrial activity.	RAG1 PRKDC	2.19e-05	5	52	2	36693372
Pubmed	The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes.	RAG1 PRKDC	2.19e-05	5	52	2	12646649
Pubmed	Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts.	RAG1 PRKDC	2.19e-05	5	52	2	22791816
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-7	2.19e-05	5	52	2	11401426
Pubmed	Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity.	RAG1 PRKDC	2.19e-05	5	52	2	30433869
Pubmed	Contribution of NK cells to the innate phase of host protection against an intracellular bacterium targeting systemic endothelium.	RAG1 PRKDC	2.19e-05	5	52	2	22617213
Pubmed	Store-Operated Ca(2+) Entry in Follicular T Cells Controls Humoral Immune Responses and Autoimmunity.	RAG1 STIM2	2.19e-05	5	52	2	27261277
Interaction	DRP2 interactions	DRP2 DTNA DAG1	1.70e-06	11	45	3	int:DRP2
Interaction	L1CAM interactions	TRIM67 NCAN NUMB HAX1	1.25e-05	64	45	4	int:L1CAM
GeneFamily	AF4/FMR2 family\|Super elongation complex	AFF1 AFF4	1.29e-05	4	27	2	1145
GeneFamily	AF4/FMR2 family\|Super elongation complex	AFF1 AFF4	7.68e-05	9	27	2	1280
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	DRP2 DTNA	3.24e-04	18	27	2	91
GeneFamily	Cytochrome P450 family 2	CYP2D7 CYP2D6	1.24e-03	35	27	2	1001
GeneFamily	Fibronectin type III domain containing	TRIM67 FN1 MYBPC1	1.70e-03	160	27	3	555
Coexpression	GSE17301_ACD3_ACD28_VS_ACD3_ACD28_AND_IFNA5_STIM_CD8_TCELL_UP	RAG1 ACSBG1 HJURP RTL10 MUC16	2.00e-05	198	44	5	M8041
Coexpression	GSE17301_CTRL_VS_48H_ACD3_ACD28_IFNA2_STIM_CD8_TCELL_DN	RAG1 ACSBG1 HJURP RTL10 MUC16	2.10e-05	200	44	5	M8039
Coexpression	DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP	HGF EPS15L1 FN1 LARP1 PRKDC MYBPC1	3.31e-05	368	44	6	M16431
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DTNA NCAN GATM PRKDC MYBPC1	1.52e-06	199	44	5	a900ef002e1ae583b70be0253d8c44dae6754916
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DRP2 ACSBG1 MTNR1A GATM	2.06e-05	164	44	4	3caf4cdaa0164907893fea61e251fd8b5fa926e4
ToppCell	TCGA-Brain\|World / Sample_Type by Project: Shred V9	DRP2 ACSBG1 DTNA NCAN	2.37e-05	170	44	4	f78e360a6a44d599ec0d207cba4704e50aa314f8
ToppCell	droplet-Liver-nan-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHGA12 GATM RALGAPA2 AFAP1L1	3.03e-05	181	44	4	a53f05c4c47465ee62e353716456bd09ab464b23
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSBG1 DTNA KICS2 GATM	3.10e-05	182	44	4	c00e503f442d44fbae73c5e2dc85be69e294e67a
ToppCell	droplet-Liver-nan-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHGA12 GATM RALGAPA2 AFAP1L1	3.17e-05	183	44	4	709a486154b3157427deb3b8886b63ac39ea42dd
ToppCell	droplet-Liver-nan-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCDHGA12 GATM RALGAPA2 AFAP1L1	3.17e-05	183	44	4	dc06f19f6f80f4c7f13f1f990c1fe0f91ba64ea7
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DRP2 ACSBG1 GATM KIAA1549	3.30e-05	185	44	4	11c147f3f5570c4761d2bcff3bad28146b4a5861
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSBG1 DTNA GATM DAG1	3.37e-05	186	44	4	d8d559daff4aeef334d403fde4e3ee2e4a6086d0
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSBG1 DTNA GATM DAG1	3.44e-05	187	44	4	16e55d802fc4e71878305e61ad03806aabd59537
ToppCell	facs-Trachea-nan-3m-Mesenchymal-smooth_muscle_cell_of_trachea\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DRP2 DTNA DAG1 MYBPC1	3.52e-05	188	44	4	794fc1d9a726945c42f7eac221eed938309b47a9
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-myocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRUNE2 FN1 DTNA MTCL1	3.59e-05	189	44	4	f7e2ee5047792ab9ef6472fa88e2d193cdea6fa0
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSBG1 DTNA GATM DAG1	3.67e-05	190	44	4	ff3dec5b45c6ea9b5319fb51a0198c6773b7be26
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 DTNA KIAA1549 MTCL1	3.67e-05	190	44	4	989d4eefd22d66ecb857836f8fdbcf41e3047f84
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSBG1 DTNA GATM DAG1	3.67e-05	190	44	4	4971857eac9af17d66d673ed2ab7072639f60a10
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-oRG-34\|World / Primary Cells by Cluster	HGF DTNA NCAN GATM	3.90e-05	193	44	4	d55f792eb3db10452347681131e07e041348fd89
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	DAG1 AFF1 PRKDC CPLANE1	3.90e-05	193	44	4	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	Control-Endothelial-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STIM2 NUMB RALGAPA2 AFAP1L1	3.90e-05	193	44	4	aff0649c73c634bc6ff0dc7759b4693a9236bf05
ToppCell	Control-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STIM2 NUMB RALGAPA2 AFAP1L1	3.90e-05	193	44	4	c5f9fe03e64c211d4bcd4959e5b32f14841e336a
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGF GATM RALGAPA2 AFAP1L1	4.30e-05	198	44	4	f0f1816a0ed3ae8207442602f5cbe4de0382e4b3
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Macroglial-Astrocyte\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	ACSBG1 DTNA NCAN GATM	4.48e-05	200	44	4	29f82e2ad2f1888b6b236a4392b88a84351b8ddc
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Mesenchymal-Mesoderm\|3m / Sample Type, Dataset, Time_group, and Cell type.	RAG1 GATM AFAP1L1 MYBPC1	4.48e-05	200	44	4	538ae964db58c4acafe93f735b3e03fc08fdaac6
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Macroglial\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	ACSBG1 DTNA NCAN GATM	4.48e-05	200	44	4	1598a9e8efa72fda7d12df07e7716b326cdf1d5e
Drug	4-hydroxydebrisoquine	CYP2D7 CYP2D6 AFF1	8.57e-07	10	45	3	CID000107669
Drug	lead nitrate	HGF ACSBG1 NR1H3 ACP4	3.36e-06	52	45	4	CID000024924
Drug	cupreidine	CYP2D7 CYP2D6	3.82e-06	2	45	2	CID000051196
Drug	3-methoxyphenethylamine	CYP2D7 CYP2D6	3.82e-06	2	45	2	CID000074866
Drug	chlorpromazine N-oxide	CYP2D7 CYP2D6	1.14e-05	3	45	2	CID000443037
Drug	2,4,6-trimethylbenzaldoxime	CYP2D7 CYP2D6	1.14e-05	3	45	2	CID000283782
Drug	O-demethyl encainide	CYP2D7 CYP2D6	1.14e-05	3	45	2	CID000054736
Drug	compound 23	ERVK-6 CYP2D7 CYP2D6	1.42e-05	24	45	3	CID000447410
Drug	encainide	CYP2D7 CYP2D6 MYBPC1	2.28e-05	28	45	3	CID000048040
Drug	4,4'-difluorobenzophenone	CYP2D7 CYP2D6	2.29e-05	4	45	2	CID000009582
Drug	Z-10	CYP2D7 CYP2D6	2.29e-05	4	45	2	CID000477529
Drug	1-(1-phenylcyclohexyl)-4-piperidinol	CYP2D7 CYP2D6	2.29e-05	4	45	2	CID000098840
Drug	desethylaprindine	CYP2D7 CYP2D6	2.29e-05	4	45	2	CID000162697
Drug	eptapirone	CYP2D7 CYP2D6	3.81e-05	5	45	2	CID000208928
Drug	Koe 1801	CYP2D7 CYP2D6	3.81e-05	5	45	2	CID000129632
Drug	2Cmp	CYP2D7 CYP2D6	3.81e-05	5	45	2	CID000023392
Drug	L-754,394	CYP2D7 CYP2D6	3.81e-05	5	45	2	CID005481990
Drug	oxosparteine	CYP2D7 CYP2D6	3.81e-05	5	45	2	CID000097492
Drug	threohydrobupropion	CYP2D7 CYP2D6	3.81e-05	5	45	2	CID000000445
Drug	4-hydroxyochratoxin A	CYP2D7 CYP2D6	3.81e-05	5	45	2	CID000114713
Drug	fenproporex	CYP2D7 CYP2D6	3.81e-05	5	45	2	CID000061810
Drug	Levonordefrin [829-74-3]; Down 200; 21.8uM; HL60; HT_HG-U133A	HGF EPS15L1 FN1 DTNA NUMB	4.15e-05	196	45	5	2710_DN
Drug	8-Methylxanthine	CYP2D7 CYP2D6	5.70e-05	6	45	2	CID000087061
Drug	AC1L45F6	CYP2D7 CYP2D6	5.70e-05	6	45	2	CID000150982
Drug	KRM1674	CYP2D7 CYP2D6	5.70e-05	6	45	2	CID000126235
Drug	5-dehydrosparteine	CYP2D7 CYP2D6	5.70e-05	6	45	2	CID000160614
Drug	nitroguanidine	CYP2D7 CYP2D6	5.70e-05	6	45	2	CID000011174
Drug	10-hydroxyochratoxin A	CYP2D7 CYP2D6	5.70e-05	6	45	2	CID000135115
Drug	7-hydroxychlorpromazine	CYP2D7 CYP2D6	5.70e-05	6	45	2	CID000016414
Drug	benzo(a)pyrene	RAG1 CYP2D7 CYP2D6 FN1 DAG1 NUMB	7.04e-05	358	45	6	CID000002336
Drug	Ben 101	CYP2D7 CYP2D6	7.97e-05	7	45	2	CID000090766
Drug	azoprocarbazine	CYP2D7 CYP2D6	7.97e-05	7	45	2	CID000075230
Drug	quinidine-N-oxide	CYP2D7 CYP2D6	7.97e-05	7	45	2	CID000050979
Drug	2-sulfamoylacetylphenol	CYP2D7 CYP2D6	7.97e-05	7	45	2	CID000194588
Drug	phenyl isocyanide	CYP2D7 CYP2D6	7.97e-05	7	45	2	CID000013606
Drug	ICI-199,441	CYP2D7 CYP2D6	7.97e-05	7	45	2	CID003082717
Drug	5,6-Dehydro-sparteine	CYP2D7 CYP2D6	7.97e-05	7	45	2	CID000523578
Drug	maprotiline	CYP2D7 CYP2D6 ACP4	9.03e-05	44	45	3	CID000004011
Drug	NSC529592	RAG1 CYP2D7 CYP2D6 FN1 NUMB	9.60e-05	234	45	5	CID000014403
Drug	anti-BaPDE	RAG1 CYP2D7 CYP2D6 DAG1 NUMB	9.60e-05	234	45	5	CID000041322
Drug	2bq7	CYP2D7 CYP2D6 GP1BA MYBPC1	1.02e-04	123	45	4	CID006540267
Drug	promethazine	CYP2D7 CYP2D6 RTL10	1.03e-04	46	45	3	CID000004927
Drug	MPBP	CYP2D7 CYP2D6	1.06e-04	8	45	2	CID000129775
Drug	pirprofen	CYP2D7 CYP2D6	1.06e-04	8	45	2	CID000035935
Drug	phenmetrazine	CYP2D7 CYP2D6	1.06e-04	8	45	2	CID000004762
Drug	AC1L9DBW	CYP2D7 CYP2D6	1.06e-04	8	45	2	CID000442742
Drug	HCBz	CYP2D7 CYP2D6	1.06e-04	8	45	2	CID000196604
Drug	beta-site	CYP2D7 CYP2D6	1.06e-04	8	45	2	CID000003914
Drug	hydroxynortriptyline	CYP2D7 CYP2D6	1.06e-04	8	45	2	CID005352542
Drug	L-754394	CYP2D7 CYP2D6	1.06e-04	8	45	2	CID000153982
Drug	B.W.306U	CYP2D7 CYP2D6	1.06e-04	8	45	2	CID000000446
Drug	Z H-H	CYP2D7 CYP2D6	1.06e-04	8	45	2	CID000004657
Drug	3,4-dihydroxymethamphetamine	CYP2D7 CYP2D6	1.06e-04	8	45	2	CID000161126
Drug	RI-331	ERVK-6 CYP2D7 CYP2D6	1.10e-04	47	45	3	CID000160754
Drug	2cgu	CYP2D7 CYP2D6 FN1	1.17e-04	48	45	3	CID003506204
Drug	6-hydroxymelatonin	CYP2D7 CYP2D6 MTNR1A	1.33e-04	50	45	3	CID000001864
Drug	hydroquinidine hydrochloride	CYP2D7 CYP2D6	1.36e-04	9	45	2	CID000003649
Drug	p-hydroxymexiletine	CYP2D7 CYP2D6	1.36e-04	9	45	2	CID000093286
Drug	norethylmorphine	CYP2D7 CYP2D6	1.36e-04	9	45	2	CID005464196
Drug	O-demethylmetoprolol	CYP2D7 CYP2D6	1.36e-04	9	45	2	CID000162181
Drug	guanoxan	CYP2D7 CYP2D6	1.36e-04	9	45	2	CID000016564
Drug	1-chlorobutane	CYP2D7 CYP2D6	1.36e-04	9	45	2	CID000008005
Drug	CP-101,606	CYP2D7 CYP2D6	1.36e-04	9	45	2	CID000219101
Drug	AC1O3M98	CYP2D7 CYP2D6	1.36e-04	9	45	2	CID006332100
Drug	lead sulfide	ERVK-6 RAG1 HGF FN1 NUMB	1.57e-04	260	45	5	CID000014819
Drug	N-(6-(6-chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)benzo(d)thiazol-2-yl)acetamide	HGF PRKDC	1.70e-04	10	45	2	ctd:C558744
Drug	AC1LCF1O	CYP2D7 CYP2D6	1.70e-04	10	45	2	CID000627285
Drug	benzaldehyde oxime	CYP2D7 CYP2D6	1.70e-04	10	45	2	CID000012143
Drug	2-hydroxydesipramine	CYP2D7 CYP2D6	1.70e-04	10	45	2	CID000121249
Drug	norchlorpromazine	CYP2D7 CYP2D6	1.70e-04	10	45	2	CID000062875
Drug	AC1L1IDP	CYP2D7 CYP2D6	1.70e-04	10	45	2	CID000004535
Drug	AC1L1HQG	CYP2D7 CYP2D6 FN1 PRKDC	1.77e-04	142	45	4	CID000004246
Drug	9-benzyladenine	CYP2D7 CYP2D6	2.08e-04	11	45	2	CID000020262
Drug	8-hydroxycarteolol	CYP2D7 CYP2D6	2.08e-04	11	45	2	CID000124688
Drug	4-hydroxy-3-methoxymethamphetamine	CYP2D7 CYP2D6	2.08e-04	11	45	2	CID003081137
Drug	o-TB	DAG1 GP1BA	2.08e-04	11	45	2	CID003015642
Drug	sphondin	CYP2D7 CYP2D6	2.08e-04	11	45	2	CID000108104
Drug	naphthohydroquinone	CYP2D7 CYP2D6	2.08e-04	11	45	2	CID000011305
Drug	vindoline	CYP2D7 CYP2D6	2.08e-04	11	45	2	CID000016596
Drug	D02861	CYP2D7 CYP2D6	2.49e-04	12	45	2	CID011954281
Drug	phenylacetone	CYP2D7 CYP2D6	2.49e-04	12	45	2	CID000007678
Drug	DB07444	RAG1 FN1	2.49e-04	12	45	2	CID006540255
Drug	methoxyphenamine	CYP2D7 CYP2D6	2.49e-04	12	45	2	CID000004117
Drug	16 alpha-hydroxytestosterone	CYP2D7 CYP2D6	2.49e-04	12	45	2	CID000065545
Drug	2-Tbmbfd	CYP2D7 CYP2D6	2.49e-04	12	45	2	CID000126928
Drug	lidocaine	CYP2D7 CYP2D6 NUMB GP1BA	2.80e-04	160	45	4	CID000003676
Drug	AC1L1JL9	CYP2D7 CYP2D6	2.94e-04	13	45	2	CID000005091
Drug	AC1L18GM	CYP2D7 CYP2D6	2.94e-04	13	45	2	CID000000092
Drug	AC1L1N5A	CYP2D7 CYP2D6	2.94e-04	13	45	2	CID000006717
Drug	dimethylthioarsinic acid	AFF1 AFF4	2.94e-04	13	45	2	ctd:C547156
Drug	Sordinol	CYP2D7 CYP2D6	2.94e-04	13	45	2	CID000012453
Drug	bergaptol	CYP2D7 CYP2D6	2.94e-04	13	45	2	CID005280371
Drug	Emetine dihydrochloride [316-42-7]; Down 200; 7.2uM; HL60; HT_HG-U133A	HGF FN1 LARP1 PRKDC	3.14e-04	165	45	4	2145_DN
Drug	AC1L89QG	CYP2D7 CYP2D6 GALT	3.31e-04	68	45	3	CID000323970
Drug	dibucaine	CYP2D7 CYP2D6 GP1BA	3.31e-04	68	45	3	CID000003025
Drug	3-hydroxylidocaine	CYP2D7 CYP2D6	3.42e-04	14	45	2	CID000161824
Drug	sesamol	CYP2D7 CYP2D6	3.42e-04	14	45	2	CID000068289
Drug	dopamine quinone	EPS15L1 CYP2D7 CYP2D6	3.45e-04	69	45	3	CID000162602
Drug	isopimpinellin	CYP2D7 CYP2D6	3.95e-04	15	45	2	CID000068079
Drug	aflatoxin Q1	CYP2D7 CYP2D6	3.95e-04	15	45	2	CID000104757
Disease	severe combined immunodeficiency (implicated_via_orthology)	RAG1 PRKDC	5.93e-06	3	42	2	DOID:627 (implicated_via_orthology)
Disease	solanidine measurement	CYP2D7 CYP2D6	1.18e-05	4	42	2	EFO_0800966
Disease	Severe Combined Immunodeficiency	RAG1 PRKDC	3.70e-04	20	42	2	C0085110
Disease	unipolar depression, response to selective serotonin reuptake inhibitor	CYP2D7 CYP2D6	5.35e-04	24	42	2	EFO_0003761, EFO_0005658
Disease	Cerebral Astrocytoma	HGF KIAA1549	5.81e-04	25	42	2	C0750935
Disease	Intracranial Astrocytoma	HGF KIAA1549	5.81e-04	25	42	2	C0750936
Disease	Pilocytic Astrocytoma	HGF KIAA1549	5.81e-04	25	42	2	C0334583
Disease	Astrocytoma	HGF KIAA1549	5.81e-04	25	42	2	C0004114
Disease	Juvenile Pilocytic Astrocytoma	HGF KIAA1549	5.81e-04	25	42	2	C0280783
Disease	Diffuse Astrocytoma	HGF KIAA1549	5.81e-04	25	42	2	C0280785
Disease	Grade I Astrocytoma	HGF KIAA1549	5.81e-04	25	42	2	C1704230
Disease	Subependymal Giant Cell Astrocytoma	HGF KIAA1549	5.81e-04	25	42	2	C0205768
Disease	Mixed oligoastrocytoma	HGF KIAA1549	5.81e-04	25	42	2	C0547065
Disease	Childhood Cerebral Astrocytoma	HGF KIAA1549	5.81e-04	25	42	2	C0338070
Disease	Gemistocytic astrocytoma	HGF KIAA1549	6.29e-04	26	42	2	C0334581
Disease	Protoplasmic astrocytoma	HGF KIAA1549	6.29e-04	26	42	2	C0334580
Disease	Fibrillary Astrocytoma	HGF KIAA1549	6.29e-04	26	42	2	C0334582
Disease	Anaplastic astrocytoma	HGF KIAA1549	6.79e-04	27	42	2	C0334579
Disease	mean corpuscular hemoglobin concentration	ACSBG1 NCAN DAG1 LARP1 AFF1 PRKDC HAX1	8.68e-04	1105	42	7	EFO_0004528
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	DRP2 DTNA	1.21e-03	36	42	2	DOID:11723 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
MVTPPSAEAHWAVRV	EPS15L1	111	Q9UBC2
PVSMDRPWETSPSIH	ERVK-19	436	O71037
PVSMDRPWEASPSVH	ERVK-8	436	Q902F8
VSMDRPWEASPSIHI	ERVK-9	436	Q9UKH3
QRLAMSWPHPADPSF	EVX2	246	Q03828
MPSSRPHRVDFCWVP	RTL10	86	Q7L3V2
KEMTHSWPPPLTAIH	AFF4	321	Q9UHB7
SPREWDPLHPSSTDM	HJURP	211	Q8NCD3
FPRNVTMEWHPHTPS	RAG1	196	P15918
EPMLSRWPCTSPRHS	MTCL1	1551	Q9Y4B5
AATEMRFPLPHAWDP	PCDHGA12	146	O60330
LPDTHWTTPRMVSPI	KIAA1549	161	Q9HCM3
TPWPMAPDPHSREAR	NR1H3	236	Q13133
ALMSRTPGDVPWLSH	MUC16	9121	Q8WXI7
SSEPDTMASWVTHPP	MUC16	11681	Q8WXI7
PPLESHVGWVMDSRE	LARP1	826	Q6PKG0
DVWPMDPHPRTREDN	HAX1	171	O00165
DEERPRPAPPDWSHM	HIRIP3	531	Q9BW71
RPAPPDWSHMRGIIS	HIRIP3	536	Q9BW71
PTPIIPDDHPLWMSS	GATM	341	P50440
ASPPVWHAVRMRASS	EZHIP	396	Q86X51
WHAVRMRASSPSPPG	EZHIP	401	Q86X51
MAQSHWPSEPSEAVR	DAG1	26	Q14118
PWSSMIPHEHSFLPS	HGF	151	P14210
SLSWRSHPDVTEPMR	RALGAPA2	696	Q2PPJ7
PVSMDRPWEASPSVH	ERVK-7	1196	P63135
SLPSDRPVMHWPNVI	KICS2	351	Q96MD2
PMDPHKEVASTLWPR	ACP4	51	Q9BZG2
SEMSEKPWSPSIPHT	CPLANE1	2586	Q9H799
VSMDRPWEASPSVHI	ERVK-24	326	P61566
PVSMDRPWEASPSIH	ERVK-25	436	P61570
PVSMDRPWEASPSVH	ERVK-6	436	Q69384
VSMDRPWEASPSVHI	ERVK-7	326	P61567
PDTMRVTWAPPPSID	FN1	1371	P02751
TEHRMTWDPAQPPRD	CYP2D6	256	P10635
FHPWSDVTLPLMSVP	GALT	131	P07902
EVEPTSHMGVPRVWE	ACSBG1	366	Q96GR2
VSMDRPWEASPSIHI	ERVK-21	436	P61565
PPRWTPNFTLHMESI	GP1BA	356	P07359
AHIVDTWPPRPVTSM	DTNA	331	Q9Y4J8
PVSMDRPWEASPSVH	HERVK_113	436	Q902F9
QAMHPDIEKAWPPTT	DHX37	1141	Q8IY37
DYSETPASSPMWPHA	DRP2	701	Q13474
PVAMPVRETNPWAHA	NUMB	386	P49757
PAFSSAPEAMHPWEL	RUNDC1	461	Q96C34
FLDHPSPSSAWMEPR	SZT2	1271	Q5T011
ASLWHSGRSPTAMPE	PRUNE2	766	Q8WUY3
EWMLPHPTPISTEAN	NCAN	641	O14594
SPQPRHQWPSEEASM	AFAP1L1	201	Q8TED9
KEMTHSWPPPLTAIH	AFF1	361	P51825
WMRPSQETTPPDRSH	CLUHP3	31	Q96NS8
TEHRMTWDPAQPPRD	CYP2D7	256	A0A087X1C5
TLAWRMPPFTHSPVD	TRIM67	531	Q6ZTA4
ALTVPSFPWVASRMH	nan	21	Q8N2B8
DHSWVVMPRVSIPPY	STIM2	461	Q9P246
WMIPTSDPAANLHPA	PRKDC	601	P78527
VASDPASMVPRIPEW	MTNR1A	261	P48039
DTTVTMRWRPPDHIG	MYBPC1	731	Q00872