Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	abnormal red blood cell deformability	PRKAG1 SPTA1	1.52e-05	3	32	2	MP:0009568
Domain	DUF3402	STRIP2 STRIP1	5.42e-06	2	44	2	PF11882
Domain	N1221	STRIP2 STRIP1	5.42e-06	2	44	2	PF07923
Domain	DUF3402	STRIP2 STRIP1	5.42e-06	2	44	2	IPR021819
Domain	DUF3402	STRIP2 STRIP1	5.42e-06	2	44	2	SM01293
Domain	N1221	STRIP2 STRIP1	5.42e-06	2	44	2	SM01292
Domain	N1221	STRIP2 STRIP1	5.42e-06	2	44	2	IPR012486
Domain	ARM-type_fold	PDS5A PPP2R5C PIK3C2A SYMPK LRRK2	1.16e-03	339	44	5	IPR016024
Domain	Spectrin	CCDC141 SPTA1	1.33e-03	23	44	2	PF00435
Domain	-	PDS5A PPP2R5C SYMPK LRRK2	1.82e-03	222	44	4	1.25.10.10
Domain	Spectrin_repeat	CCDC141 SPTA1	2.11e-03	29	44	2	IPR002017
Domain	WD40	WDR73 HERC1 GTF3C2 LRRK2	3.59e-03	268	44	4	SM00320
Domain	ARM-like	PDS5A PPP2R5C SYMPK LRRK2	3.68e-03	270	44	4	IPR011989
Domain	WD40_repeat	WDR73 HERC1 GTF3C2 LRRK2	3.78e-03	272	44	4	IPR001680
Domain	WD40_repeat_dom	WDR73 HERC1 GTF3C2 LRRK2	5.16e-03	297	44	4	IPR017986
Domain	p53-like_TF_DNA-bd	STAT2 NFKB1	6.93e-03	53	44	2	IPR008967
Domain	-	WDR73 HERC1 GTF3C2 LRRK2	7.69e-03	333	44	4	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	WDR73 HERC1 GTF3C2 LRRK2	7.85e-03	335	44	4	IPR015943
Pubmed	Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae.	STRIP2 STRIP1	1.71e-06	2	46	2	12588993
Pubmed	The protein phosphatase 2A regulatory subunit B56γ mediates suppression of T cell receptor (TCR)-induced nuclear factor-κB (NF-κB) activity.	PPP2R5C NFKB1	1.71e-06	2	46	2	24719332
Pubmed	TORC2 signaling is antagonized by protein phosphatase 2A and the Far complex in Saccharomyces cerevisiae.	STRIP2 STRIP1	1.71e-06	2	46	2	22298706
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	PDS5A KMT2C NUP93 GTF3C2 NOP56 CCDC141 NFKB1	2.64e-06	469	46	7	27634302
Pubmed	The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling.	STRIP2 STRIP1	5.13e-06	3	46	2	22782902
Pubmed	The STRIPAK complex components FAM40A and FAM40B regulate endothelial cell contractility via ROCKs.	STRIP2 STRIP1	5.13e-06	3	46	2	30509168
Pubmed	AKAP13, a RhoA GTPase-specific guanine exchange factor, is a novel regulator of TLR2 signaling.	AKAP13 NFKB1	5.13e-06	3	46	2	17878165
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	PPP2R5C NUP93 HERC1 NOP56 STRIP2 STRIP1 LRRC1	9.74e-06	573	46	7	28330616
Pubmed	IRF9 and unphosphorylated STAT2 cooperate with NF-κB to drive IL6 expression.	STAT2 NFKB1	1.03e-05	4	46	2	29581268
Pubmed	Human transcription factor protein interaction networks.	RLF PDS5A KMT2C NUP93 HERC1 GTF3C2 NOP56 STAT2 NFKB1 SYMPK	1.40e-05	1429	46	10	35140242
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	RLF ITPRIP PDS5A DTX3L PPP2R5C NUP93 RDH11 STRIP1 SYMPK	2.39e-05	1203	46	9	29180619
Pubmed	STRIPAK components determine mode of cancer cell migration and metastasis.	STRIP2 STRIP1	2.56e-05	6	46	2	25531779
Pubmed	Th17-associated cytokines promote human airway smooth muscle cell proliferation.	IL17RC NFKB1	2.56e-05	6	46	2	22898922
Pubmed	A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.	PPP2R5C STRIP2 STRIP1	3.16e-05	46	46	3	18782753
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	ITPRIP KMT2C AKAP13 DTX3L RNPC3 NFKB1 SYMPK	3.18e-05	689	46	7	36543142
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	PDS5A KMT2C NUP93 TIGD2 GTF3C2 NOP56 SPTA1 POLR2D SYMPK	4.22e-05	1294	46	9	30804502
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PPP2R5C NUP93 CRYBG3 HERC1 NFKB1 POLR2D LRRC1 SYMPK	6.29e-05	1049	46	8	27880917
Pubmed	Tagging genes with cassette-exchange sites.	PRKAG1 KMT2C AKAP13 PPP2R5C POLR2D	7.98e-05	335	46	5	15741177
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	PDS5A PPP2R5C NUP93 GTF3C2 LRRC1 SYMPK	9.20e-05	560	46	6	35241646
Pubmed	Nef, the shuttling molecular adaptor of HIV, influences the cytokine network.	STAT2 NFKB1	9.34e-05	11	46	2	25529283
Pubmed	HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: involvement of TNF alpha receptor associated factor 2.	STAT2 NFKB1	9.34e-05	11	46	2	21886773
Pubmed	Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.	STAT2 NFKB1	9.34e-05	11	46	2	19169254
Pubmed	Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial.	STAT2 NFKB1	1.32e-04	13	46	2	19434718
Pubmed	Aurora B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin.	PDS5A PPP2R5C	1.78e-04	15	46	2	23901111
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	PRKAG1 PDS5A STRIP2 STRIP1	1.79e-04	212	46	4	33853758
Pubmed	A conserved acetylation switch enables pharmacological control of tubby-like protein stability.	PRKAG1 WDR73 GTF3C2 STRIP1	2.17e-04	223	46	4	33187986
Pubmed	Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes.	PIK3C2A NFKB1	2.30e-04	17	46	2	23251686
Pubmed	The cleavage of host cell proteins by HIV-1 protease.	SPTA1 NFKB1	2.30e-04	17	46	2	8997639
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	PRKAG1 TIGD2 PIK3C2A RALGPS1 LRRC1 LRRK2	2.76e-04	686	46	6	29987050
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	KMT2C NOP56 RNPC3 SYMPK	3.41e-04	251	46	4	31076518
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	RLF PDS5A AKAP13 NUP93 GTF3C2 NOP56 RDH11 PIK3C2A	3.59e-04	1353	46	8	29467282
Pubmed	An integrated workflow for charting the human interaction proteome: insights into the PP2A system.	PPP2R5C NFKB1 STRIP1	3.69e-04	105	46	3	19156129
Pubmed	HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.	PRKAG1 NFKB1	4.25e-04	23	46	2	9730685
Pubmed	The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.	PRKAG1 NFKB1	4.25e-04	23	46	2	9278385
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ITPRIP KMT2C AEN PPP2R5C HERC1 NOP56 FMN1	5.19e-04	1084	46	7	11544199
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KMT2C PPP2R5C NUP93 GTF3C2 RALGPS1	6.55e-04	529	46	5	14621295
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RLF PRKAG1 KMT2C AKAP13 RDH11 RALGPS1 DNAH14 LRRC1	6.77e-04	1489	46	8	28611215
Pubmed	Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.	STRIP2 STRIP1	6.79e-04	29	46	2	21834987
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	ITPRIP PDS5A PPP2R5C NUP93 GTF3C2 NOP56 STRIP1	7.55e-04	1155	46	7	20360068
Pubmed	Defining the membrane proteome of NK cells.	PRKAG1 ITPRIP AKAP13 NUP93 NOP56 PIK3C2A PEX3	8.06e-04	1168	46	7	19946888
Pubmed	Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.	PRKAG1 PDS5A PPP2R5C NUP93	8.76e-04	323	46	4	24797263
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	PDS5A DTX3L GTF3C2 SYMPK	1.06e-03	340	46	4	24332808
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	PRKAG1 AKAP13 NUP93 GTF3C2 NOP56	1.16e-03	601	46	5	33658012
Pubmed	Image-based genome-wide siRNA screen identifies selective autophagy factors.	NUP93 STAT2 PEX3	1.23e-03	159	46	3	22020285
Pubmed	Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress.	PDS5A NUP93 NOP56	1.23e-03	159	46	3	22751105
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	PDS5A AKAP13 PPP2R5C NUP93 NOP56 POLR2D	1.25e-03	916	46	6	32203420
GeneFamily	Protein phosphatase catalytic subunits\|STRIPAK complex	STRIP2 STRIP1	6.38e-04	20	34	2	1371
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	RLF PDS5A AKAP13 PPP2R5C CRYBG3 GTF3C2 PIK3C2A NFKB1 PEX3	1.25e-05	856	45	9	M4500
Coexpression	GSE14769_40MIN_VS_360MIN_LPS_BMDM_DN	ITPRIP KMT2C AEN AKAP13 HERC1	2.29e-05	199	45	5	M3517
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-like-AT2_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	WDR73 FMN1 RALGPS1 SPTA1	2.71e-05	168	46	4	9e7b4b9b977e90e083f5164013e79df8bc2d492e
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	CCDC141 PIK3C2A FMN1 RALGPS1	3.18e-05	175	46	4	f3a68aeb79c4935006e17a5ff3445a8ec0e33f5f
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	AKAP13 CCDC141 FMN1 LRRK2	4.11e-05	187	46	4	5df9e1f5ca32217af255e76e6fb5afa346337811
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	RLF KMT2C HERC1 NFKB1	4.20e-05	188	46	4	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CCDC92 FMN1 DNAH14 LRRK2	4.47e-05	191	46	4	34cc997e4e5c727495f321e6807a84aa124da486
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CCDC141 FMN1 DNAH14 LRRK2	4.56e-05	192	46	4	fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	KMT2C PPP2R5C HERC1 NFKB1	4.56e-05	192	46	4	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	COPD-Myeloid-Macrophage\|World / Disease state, Lineage and Cell class	AKAP13 FMN1 NFKB1 LRRK2	4.75e-05	194	46	4	7d682408e9a6239a4e47befc9376e760cc3d133a
ToppCell	Control-Epithelial-ATII\|Epithelial / Disease state, Lineage and Cell class	AKAP13 CCDC141 NFKB1 LRRK2	4.75e-05	194	46	4	a01de094f7bfd099bcbb2f94224690a2efb887b4
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	KMT2C PPP2R5C HERC1 RNPC3	5.04e-05	197	46	4	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	KMT2C AKAP13 DTX3L STAT2	5.34e-05	200	46	4	12f1685ce8f218433068e090c9d839cd5a1910bf
Disease	neurodegenerative disease (implicated_via_orthology)	TBPL2 PRKAG1 NFKB1 LRRK2	6.52e-05	145	44	4	DOID:1289 (implicated_via_orthology)
Disease	hypertrophic cardiomyopathy	KMT2C CCDC141 SYMPK	3.54e-04	92	44	3	EFO_0000538
Disease	maximal oxygen uptake measurement	NUP93 CCDC141	6.90e-04	26	44	2	EFO_0004887
Disease	eye measurement	AKAP13 HERC1	7.45e-04	27	44	2	EFO_0004731
Disease	apolipoprotein B measurement	CCDC92 NUP93 GTF3C2 ABCA8 SYMPK	2.97e-03	663	44	5	EFO_0004615
Disease	platelet component distribution width	PDS5A AKAP13 HERC1 SPTA1 LRRK2	5.15e-03	755	44	5	EFO_0007984
Disease	triglycerides to total lipids in small HDL percentage	CCDC92 ABCA8	5.20e-03	72	44	2	EFO_0022336
Disease	cholesteryl ester measurement	CCDC92 NUP93 ABCA8	6.65e-03	257	44	3	EFO_0010351
Disease	very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	CCDC92 NUP93 ABCA8	7.16e-03	264	44	3	EFO_0008317, EFO_0020944
Disease	Antihypertensive use measurement	THAP3 CCDC141 RALGPS1	7.23e-03	265	44	3	EFO_0009927

Protein segments in the cluster

Peptide	Gene	Start	Entry
RLTVLLNKKDKHLSL	TRAV5	81	A0A0B4J249
RVSLKDLALQLLHKK	AEN	231	Q8WTP8
ILTHKRILKFLKLFI	PRKAG1	166	P54619
LEAKKAGLKLALHLS	ADAL	196	Q6DHV7
AALLHLSNCRKLKKL	AMN1	76	Q8IY45
ALKKLIHAAKLNASL	CTAGE3P	121	Q8IX95
HDQLLDLKSSLLKKA	CRYBG3	1186	Q68DQ2
SLDKKLVLAFRHLKL	AKAP13	131	Q12802
FLLKVLLPLHKVKSL	PPP2R5C	246	Q13362
HVALVLFELKLLLKS	NUP93	491	Q8N1F7
IFAQKLHKALVKLLL	PDS5A	931	Q29RF7
ILSHFVKIAKKLLEL	RALGPS1	121	Q5JS13
LLHVKSVKDILALIL	FMN1	1171	Q68DA7
LLCFLEKSLLQKKLH	ITPRIP	461	Q8IWB1
LRLLLETHLPSKKKK	NOP56	76	O00567
LLKHLLKNKKSSSLL	KMT2C	3776	Q8NEZ4
LKLCLKLLSNHLALA	HERC1	791	Q15751
IKGKLLDILHKDSSL	PIK3C2A	871	O00443
LKHSLSLLDLEQKLK	PEX3	196	P56589
LRLKELKILNLSKNH	LRRK2	1126	Q5S007
LHLPLSLTALKLKAL	LRRC1	371	Q9BTT6
KKLLHDHELLLAKLK	CCDC141	61	Q6ZP82
EVLLLKSLGKERKHL	DTX3L	451	Q8TDB6
LEELKAKSHKLTLLS	CCDC92	131	Q53HC0
KLLFVIHKSLKDLQL	DNAH14	3206	Q0VDD8
AILSLLVLKERALHK	GPR173	41	Q9NS66
KLLADLHKREKELSL	CCDC158	381	Q5M9N0
AALSLILLLKKDHAK	IL17RC	551	Q8NAC3
QKKLKLLLADLHVKS	KIF2B	656	Q8N4N8
KLFEILKKDHQLLLA	TARS3	136	A2RTX5
LGHFLLTHLLLEKLK	RDH11	151	Q8TC12
LLLQKKLHKFELACL	POLR2D	86	O15514
AKLLFHLRQLLKELK	STAT2	266	P52630
TLLLLLLKHFKLNHI	STRIP2	576	Q9ULQ0
KKAHELLVLNGLLLI	BMT2	261	Q1RMZ1
KAISAVLLLLLKHFK	STRIP1	576	Q5VSL9
KTHASLFKKILLGLL	SLC28A2	71	O43868
LKHERKALLALLLIL	ABCA8	856	O94911
KHLKSKGLLEKAVLL	TIGD2	276	Q4W5G0
KAAIKALTRLHQLKL	RNPC3	76	Q96LT9
LELLLRLKHLSLKNS	RLF	1061	Q13129
PLATRKKKLLDLLHL	SPTA1	781	P02549
KKKLLDLLHLQLICR	SPTA1	786	P02549
SVRKNLKLHLLSVLK	SYMPK	296	Q92797
KSKAELLLLKLSKDL	GTF3C2	146	Q8WUA4
LLEKSLHCLKKAVRL	TTC37	806	Q6PGP7
ALLDLDSLKKKLFLT	THAP3	181	Q8WTV1
LKKNEILHLKLPLRL	WDR73	46	Q6P4I2
LACKLDLKKIALHAK	TBPL2	211	Q6SJ96
LSILLKHKKAALLLD	NFKB1	631	P19838