Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	FOXD2 SOX3 HNF1A PTF1A PATZ1 ARX E2F3 IRX3 ZNF467 CASZ1 KMT2D EGR3 GLI2 NFKB2 PITX3 ELK1 FOXF1 FOXD1	3.95e-08	560	134	18	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	FOXD2 SOX3 HNF1A PTF1A PATZ1 ARX E2F3 IRX3 ZNF467 CASZ1 KMT2D EGR3 GLI2 NFKB2 PITX3 ELK1 FOXF1 FOXD1	4.64e-08	566	134	18	GO:0001216
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	FOXD2 SOX3 HNF1A ZNF444 SALL3 ERFL PTF1A PATZ1 NTN3 ARX KLF14 E2F3 IRX3 ZNF467 CASZ1 HIVEP3 KLF16 KMT2D EGR3 GLI2 SKOR2 NFKB2 BHLHE22 PITX3 DMRTA2 ELK1 FOXF1 FOXD1	1.78e-07	1412	134	28	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	FOXD2 SOX3 HNF1A ZNF444 SALL3 PTF1A PATZ1 NTN3 ARX KLF14 E2F3 IRX3 ZNF467 HIVEP3 KLF16 EGR3 GLI2 SKOR2 NFKB2 BHLHE22 PITX3 DMRTA2 ELK1 SNAPC4 FOXF1 FOXD1	1.93e-07	1244	134	26	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	FOXD2 SOX3 HNF1A ZNF444 SALL3 PTF1A PATZ1 NTN3 ARX KLF14 E2F3 IRX3 ZNF467 HIVEP3 KLF16 EGR3 GLI2 SKOR2 NFKB2 BHLHE22 PITX3 DMRTA2 ELK1 SNAPC4 FOXF1 FOXD1	2.93e-07	1271	134	26	GO:0000987
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	FOXD2 SOX3 HNF1A ZNF444 SALL3 PTF1A PATZ1 NTN3 ARX KLF14 AIRE E2F3 IRX3 ZNF467 CASZ1 HIVEP3 KLF16 EGR3 GLI2 SKOR2 NFKB2 BHLHE22 PITX3 DMRTA2 ELK1 SNAPC4 FOXF1 FOXD1	3.47e-07	1459	134	28	GO:0000977
GeneOntologyMolecularFunction	transcription coregulator activity	ZXDC BCL9L LIMD1 NACA SIAH2 ZFPM1 CBFA2T3 KMT2D TLE5 MAMSTR IRF2BPL ELK1 DOT1L	1.07e-04	562	134	13	GO:0003712
GeneOntologyMolecularFunction	molecular adaptor activity	ZXDC MAPK8IP1 BCL9L ZSWIM8 VPS11 LIMD1 NACA SIAH2 ZFPM1 ATG2A CBFA2T3 CRKL KMT2D AP2A2 TLE5 MAMSTR IRF2BPL ELK1 LTBP1 DOT1L UBE2Z	2.72e-04	1356	134	21	GO:0060090
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	ZXDC MAPK8IP1 BCL9L ZSWIM8 VPS11 LIMD1 NACA SIAH2 ZFPM1 ATG2A CBFA2T3 CRKL KMT2D AP2A2 TLE5 MAMSTR IRF2BPL ELK1 DOT1L	2.74e-04	1160	134	19	GO:0030674
GeneOntologyMolecularFunction	chromatin binding	HNF1A PTF1A PATZ1 ARX KLF14 AIRE CBFA2T3 MBD6 CBX6 GLI2 SKOR2 BHLHE22 MLLT6 ELK1	4.52e-04	739	134	14	GO:0003682
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	FOXD2 SOX3 BCL9L HNF1A PTF1A PATZ1 NACA ARX KLF14 AIRE TNIP1 E2F3 IRX3 ZFPM1 ZNF467 CASZ1 TAF3 KMT2D EGR3 GLI2 NFKB2 BHLHE22 PITX3 MEPCE MAMSTR MLLT6 IRF2BPL ELK1 PRKD1 DOT1L FOXF1 FOXD1 AGAP2	4.78e-11	1390	134	33	GO:0045944
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	SOX3 HNF1A LIMD1 PATZ1 NACA ARX SIK1 SIAH2 IRX3 ZFPM1 CBFA2T3 ZNF503 KLF16 TAF3 TLE5 CBX6 GLI2 SKOR2 BHLHE22 MEPCE IRF2BPL TSC22D4 FOXF1 FOXD1	1.08e-05	1399	134	24	GO:0045892
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	SOX3 HNF1A LIMD1 PATZ1 NACA ARX SIK1 SIAH2 IRX3 ZFPM1 CBFA2T3 ZNF503 KLF16 TAF3 TLE5 CBX6 GLI2 SKOR2 BHLHE22 MEPCE IRF2BPL TSC22D4 FOXF1 FOXD1	1.27e-05	1413	134	24	GO:1902679
GeneOntologyBiologicalProcess	cerebellar cortex morphogenesis	WHRN TRNP1 ATXN2 GLI2 SKOR2	1.47e-05	48	134	5	GO:0021696
GeneOntologyBiologicalProcess	postsynapse assembly	LRFN1 RTN4 CRKL NRXN2 CASKIN1 ARHGAP33	3.22e-05	93	134	6	GO:0099068
GeneOntologyBiologicalProcess	cerebellum development	WHRN TRNP1 PTF1A CRKL ATXN2 GLI2 SKOR2	3.49e-05	139	134	7	GO:0021549
GeneOntologyBiologicalProcess	cerebellum morphogenesis	WHRN TRNP1 ATXN2 GLI2 SKOR2	4.40e-05	60	134	5	GO:0021587
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase II	SOX3 HNF1A PATZ1 NACA ARX SIK1 IRX3 ZFPM1 CBFA2T3 KLF16 TAF3 TLE5 CBX6 GLI2 SKOR2 MEPCE IRF2BPL TSC22D4 FOXF1	5.11e-05	1053	134	19	GO:0000122
GeneOntologyBiologicalProcess	hindbrain morphogenesis	WHRN TRNP1 ATXN2 GLI2 SKOR2	6.02e-05	64	134	5	GO:0021575
GeneOntologyBiologicalProcess	metencephalon development	WHRN TRNP1 PTF1A CRKL ATXN2 GLI2 SKOR2	6.44e-05	153	134	7	GO:0022037
GeneOntologyBiologicalProcess	cell morphogenesis	WHRN BCL9L LIMD1 SZT2 NTN3 RTN4 ARX TRIOBP LGR4 ZFPM1 SSH1 ATXN2 GLI2 SKOR2 BHLHE22 ARHGAP44 TSC22D4 ULK2 ARHGAP33 FOXD1	8.92e-05	1194	134	20	GO:0000902
GeneOntologyBiologicalProcess	cerebellar cortex development	WHRN TRNP1 ATXN2 GLI2 SKOR2	9.91e-05	71	134	5	GO:0021695
GeneOntologyBiologicalProcess	brain development	SOX3 WHRN KIF21B TRNP1 SALL3 SZT2 PTF1A RTN4 ARX CRKL ATXN2 GLI2 SKOR2 BHLHE22 PITX3 DMRTA2	1.46e-04	859	134	16	GO:0007420
GeneOntologyBiologicalProcess	neuron development	WHRN SALL3 UBE4B SZT2 NTN3 RTN4 ARX TRIOBP LGR4 CRKL ATXN2 GLI2 SKOR2 BHLHE22 ARHGAP44 PITX3 PRKD1 GRIN3A TSC22D4 ULK2 ARHGAP33 FOXD1	1.84e-04	1463	134	22	GO:0048666
GeneOntologyBiologicalProcess	postsynaptic specialization assembly	LRFN1 CRKL NRXN2 CASKIN1	1.89e-04	44	134	4	GO:0098698
GeneOntologyBiologicalProcess	animal organ morphogenesis	SOX3 WHRN HNF1A UBE4B PTF1A NTN3 RTN4 NACA TRIOBP LGR4 IRX3 ZFPM1 CASZ1 LFNG CRKL GLI2 BHLHE22 PITX3 FOXF1 FOXD1	2.02e-04	1269	134	20	GO:0009887
GeneOntologyBiologicalProcess	amacrine cell differentiation	PTF1A CASZ1 BHLHE22	2.04e-04	18	134	3	GO:0035881
GeneOntologyBiologicalProcess	neuron projection development	WHRN UBE4B SZT2 NTN3 RTN4 ARX TRIOBP LGR4 CRKL ATXN2 GLI2 SKOR2 BHLHE22 ARHGAP44 PRKD1 GRIN3A TSC22D4 ULK2 ARHGAP33 FOXD1	2.38e-04	1285	134	20	GO:0031175
GeneOntologyBiologicalProcess	cerebellar Purkinje cell layer formation	WHRN ATXN2 SKOR2	2.82e-04	20	134	3	GO:0021694
GeneOntologyBiologicalProcess	head development	SOX3 WHRN KIF21B TRNP1 SALL3 SZT2 PTF1A RTN4 ARX CRKL ATXN2 GLI2 SKOR2 BHLHE22 PITX3 DMRTA2	3.13e-04	919	134	16	GO:0060322
GeneOntologyBiologicalProcess	neuron fate commitment	PTF1A CASZ1 GLI2 BHLHE22 DMRTA2	3.19e-04	91	134	5	GO:0048663
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	WHRN SZT2 NTN3 RTN4 ARX TRIOBP LGR4 GLI2 SKOR2 BHLHE22 ARHGAP44 ULK2 ARHGAP33 FOXD1	3.70e-04	748	134	14	GO:0048667
GeneOntologyBiologicalProcess	regulation of protein localization to endoplasmic reticulum	RTN4 NACA	4.14e-04	5	134	2	GO:1905550
GeneOntologyBiologicalProcess	hindbrain development	WHRN TRNP1 PTF1A CRKL ATXN2 GLI2 SKOR2	4.27e-04	208	134	7	GO:0030902
GeneOntologyCellularComponent	chromatin	FOXD2 SOX3 TRNP1 HNF1A PTF1A BICRA ARX KLF14 E2F3 IRX3 ZFPM1 CASZ1 KLF16 EGR3 CBX6 NFKB2 BHLHE22 PITX3 DMRTA2 ELK1 FOXF1 FOXD1	1.43e-04	1480	132	22	GO:0000785
Domain	EGD2/NACA	NACA NACAD	1.46e-04	3	131	2	IPR016641
Domain	TSC-22_Dip_Bun	TSC22D2 TSC22D4	2.90e-04	4	131	2	IPR000580
Domain	TSC-22_Dip_Bun	TSC22D2 TSC22D4	2.90e-04	4	131	2	PD007152
Domain	TSC22	TSC22D2 TSC22D4	2.90e-04	4	131	2	PF01166
Domain	TSC22	TSC22D2 TSC22D4	2.90e-04	4	131	2	PS01289
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ZXDC KCTD12 TRNP1 LRFN1 UBE4B SZT2 BICRA SIAH2 ZFPM1 ATG2A MBD6 DENND1A CASZ1 ANO8 CABLES1 ZNF503 HIVEP3 SEPHS2 EHBP1L1 KMT2D SSH1 TMEM259 CASKIN1 NFKB2 ARHGAP44 NAV1 MLLT6 DOT1L SNAPC4 ULK2 ARHGAP33	6.44e-18	1105	138	31	35748872
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXD2 SOX3 HNF1A ZNF444 PTF1A PATZ1 ARX AIRE E2F3 IRX3 ZFPM1 TSC22D2 HIVEP3 KLF16 KMT2D EGR3 GLI2 SKOR2 NFKB2 BHLHE22 PITX3 DMRTA2 ELK1 TSC22D4 SNAPC4 FOXF1	2.62e-15	908	138	26	19274049
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	FOXD2 SOX3 ZNF444 PTF1A ARX KLF14 E2F3 IRX3 KLF16 EGR3 GLI2 SKOR2 NFKB2 BHLHE22 PITX3 DMRTA2 ELK1	6.59e-11	544	138	17	28473536
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	KIF21B KCTD12 MAPK8IP1 LRFN1 HCN4 PATZ1 TRIOBP SIRPB1 SEC24C AP2A2 SSH1 ATXN2 TMEM259 CASKIN1 ARHGAP44 NAV1 PRKD1 AGAP2 MTSS2	9.77e-09	963	138	19	28671696
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	EP400P1 ZNF444 LIMD1 UBE4B EPB41L4B BICRA SLC22A23 TRIOBP E2F3 DENND1A CEP43 SNX29 CASZ1 ANO8 HIVEP3 TLE5 ATXN2 GLI2 ARHGAP44 NAV1 PRKD1 TSC22D4	1.05e-07	1489	138	22	28611215
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KIF21B RELCH SZT2 TEX2 RTN4 NACA TRIOBP E2F3 ATG2A NACAD NRXN2 CASKIN1 ANKS3	2.11e-07	529	138	13	14621295
Pubmed	Cilia-dependent GLI processing in neural crest cells is required for tongue development.	FOXD2 GLI2 FOXF1 FOXD1	2.30e-07	14	138	4	28286175
Pubmed	Human transcription factor protein interaction networks.	BCL9L HNF1A LIMD1 USP11 BICRA NACA TNIP1 E2F3 MBD6 ZNF503 KLF16 TAF3 KMT2D TLE5 ATXN2 PRCC GLI2 NFKB2 MLLT6 IRF2BPL DOT1L	2.31e-07	1429	138	21	35140242
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	SOX3 ZXDC HNF1A SALL3 LIMD1 PATZ1 AIRE HIVEP3 KLF16 NFKB2 MLLT6 ELK1 TSC22D4 SNAPC4	4.41e-06	808	138	14	20412781
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KCTD12 TNIP1 CASZ1 ANO8 HIVEP3 AP2A2 SSH1 ATRNL1 IRF2BPL FHDC1 GRIN3A	4.75e-06	493	138	11	15368895
Pubmed	Phosphoproteomic analysis of the developing mouse brain.	KIF21B KCTD12 UBE4B RTN4 NACA CRKL USP5 IRF2BPL	6.73e-06	246	138	8	15345747
Pubmed	DNA-binding specificities of human transcription factors.	FOXD2 KLF14 E2F3 EGR3	6.87e-06	31	138	4	23332764
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	VPS11 LIMD1 TEX2 TRIOBP SNX29 CABLES1 SEC24C DOT1L	7.79e-06	251	138	8	29778605
Pubmed	Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family.	FOXD2 FOXF1 FOXD1	9.85e-06	11	138	3	7683413
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	KCTD12 MAPK8IP1 BCL9L RELCH HCN4 TEX2 RTN4 NACA TRIOBP NACAD ANO8 CRKL AP2A2 CASKIN1 NAV1 AGAP2	1.25e-05	1139	138	16	36417873
Pubmed	The transcription factor Egr3 is a putative component of the microtubule organizing center in mouse oocytes.	EGR3 FMN2	1.56e-05	2	138	2	24722338
Pubmed	Repression of HNF1α-mediated transcription by amino-terminal enhancer of split (AES).	HNF1A TLE5	1.56e-05	2	138	2	26549228
Pubmed	The Lineage Differentiation and Dynamic Heterogeneity of Thymic Epithelial Cells During Thymus Organogenesis.	HNF1A AIRE BPIFA1	3.30e-05	16	138	3	35273595
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	ZSWIM8 SIAH2 TNIP1 MBD6 BPIFA1 TLE5 ATXN2 MLLT6 LTBP1 TSC22D4 ANKS3	3.31e-05	608	138	11	16713569
Pubmed	ISL1/SHH/CXCL12 signaling regulates myogenic cell migration during mouse tongue development.	FOXD2 FOXF1 FOXD1	3.99e-05	17	138	3	36196625
Pubmed	Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia.	PTF1A PRKD1	4.68e-05	3	138	2	25698580
Pubmed	Reduced thymic Aire expression and abnormal NF-kappa B2 signaling in a model of systemic autoimmunity.	AIRE NFKB2	4.68e-05	3	138	2	19234163
Pubmed	High-Resolution 3D Heart Models of Cardiomyocyte Subpopulations in Cleared Murine Heart.	PNMT HCN4	4.68e-05	3	138	2	35665220
Pubmed	Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution.	KLF14 KLF16	4.68e-05	3	138	2	17480121
Pubmed	Protein kinase D regulates cell migration by direct phosphorylation of the cofilin phosphatase slingshot 1 like.	SSH1 PRKD1	4.68e-05	3	138	2	19567672
Pubmed	Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot.	SSH1 PRKD1	4.68e-05	3	138	2	19329994
Pubmed	Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila.	TSC22D2 TSC22D4	4.68e-05	3	138	2	20149264
Pubmed	Protein Kinase D1, Reduced in Human Pancreatic Tumors, Increases Secretion of Small Extracellular Vesicles From Cancer Cells That Promote Metastasis to Lung in Mice.	PTF1A PRKD1	4.68e-05	3	138	2	32446697
Pubmed	PLCε, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart.	SSH1 PRKD1	4.68e-05	3	138	2	24345679
Pubmed	Dysfunctional EGFR and oxidative stress-induced PKD1 signaling drive formation of DCLK1+ pancreatic stem cells.	PTF1A PRKD1	4.68e-05	3	138	2	33521594
Pubmed	Three-dimensional molecular architecture of mouse organogenesis.	HNF1A ARX IRX3 FOXF1 FOXD1	5.09e-05	100	138	5	37524711
Pubmed	Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia.	FOXD2 FOXF1 FOXD1	5.65e-05	19	138	3	15107405
Pubmed	AF17 facilitates Dot1a nuclear export and upregulates ENaC-mediated Na+ transport in renal collecting duct cells.	MLLT6 DOT1L	9.33e-05	4	138	2	22087315
Pubmed	The PRKD1 promoter is a target of the KRas-NF-κB pathway in pancreatic cancer.	PTF1A PRKD1	9.33e-05	4	138	2	27649783
Pubmed	HNF1A recruits KDM6A to activate differentiated acinar cell programs that suppress pancreatic cancer.	HNF1A PTF1A	9.33e-05	4	138	2	32154941
Pubmed	AF17 competes with AF9 for binding to Dot1a to up-regulate transcription of epithelial Na+ channel alpha.	MLLT6 DOT1L	9.33e-05	4	138	2	19864429
Pubmed	USP11 degrades KLF4 via its deubiquitinase activity in liver diseases.	USP11 USP5	9.33e-05	4	138	2	34114341
Pubmed	Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins.	NRXN2 GRIN3A	9.33e-05	4	138	2	14983056
Pubmed	Connecdenn, a novel DENN domain-containing protein of neuronal clathrin-coated vesicles functioning in synaptic vesicle endocytosis.	DENND1A AP2A2	9.33e-05	4	138	2	17182770
Pubmed	Specific TSC22 domain transcripts are hypertonically induced and alternatively spliced to protect mouse kidney cells during osmotic stress.	TSC22D2 TSC22D4	9.33e-05	4	138	2	17147695
Pubmed	NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathway.	AIRE NFKB2	9.33e-05	4	138	2	17039258
Pubmed	cDNAs with long CAG trinucleotide repeats from human brain.	KMT2D ATXN2 BHLHE22	1.02e-04	23	138	3	9225980
Pubmed	Expression of Groucho/TLE proteins during pancreas development.	HNF1A ARX TLE5	1.16e-04	24	138	3	18778483
Pubmed	The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.	SALL3 IRX3 TLE5 GLI2 PITX3 FOXD1	1.20e-04	191	138	6	24146773
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	WHRN KIF21B NAAA USP11 NACAD KCNH4 USP5 EHBP1L1 AP2A2 CBX6 MAMSTR LTBP1 DOT1L SNAPC4 MTSS2	1.30e-04	1242	138	15	30973865
Pubmed	Gsg1, Trnp1, and Tmem215 Mark Subpopulations of Bipolar Interneurons in the Mouse Retina.	TRNP1 HCN4 BHLHE22	1.32e-04	25	138	3	28199486
Pubmed	The Rab11-binding protein RELCH/KIAA1468 controls intracellular cholesterol distribution.	RELCH EHBP1L1	1.55e-04	5	138	2	29514919
Pubmed	Mouse Mesenchyme forkhead 2 (Mf2): expression, DNA binding and induction by sonic hedgehog during somitogenesis.	FOXD2 FOXD1	1.55e-04	5	138	2	9510020
Pubmed	Targeted insertion of the Cre-recombinase gene at the phenylethanolamine n-methyltransferase locus: a new model for studying the developmental distribution of adrenergic cells.	PNMT HCN4	1.55e-04	5	138	2	15517585
Pubmed	The Ap-2α/Elk-1 axis regulates Sirpα-dependent tumor phagocytosis by tumor-associated macrophages in colorectal cancer.	SIRPB1 ELK1	1.55e-04	5	138	2	32296015
Pubmed	Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns.	AIRE FOXD1	1.55e-04	5	138	2	26726812
Pubmed	The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79.	MLLT6 DOT1L	1.55e-04	5	138	2	26439302
Pubmed	Mammalian COPII coat component SEC24C is required for embryonic development in mice.	PTF1A SEC24C	1.55e-04	5	138	2	24876386
Pubmed	MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme.	FOXD2 HNF1A	1.55e-04	5	138	2	8325367
Pubmed	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.	VPS11 RTN4 CEP43 ZNF503 AP2A2 TLE5 MEPCE	1.97e-04	298	138	7	32353859
Pubmed	Insights into the etiology and physiopathology of MODY5/HNF1B pancreatic phenotype with a mouse model of the human disease.	HNF1A PTF1A ARX	2.07e-04	29	138	3	33527355
Pubmed	MFng is dispensable for mouse pancreas development and function.	PTF1A ARX LFNG	2.29e-04	30	138	3	19223466
Pubmed	Pax6 is required for normal cell-cycle exit and the differentiation kinetics of retinal progenitor cells.	PTF1A GLI2 BHLHE22	2.29e-04	30	138	3	24073291
Pubmed	Single-cell transcriptomic landscapes of the otic neuronal lineage at multiple early embryonic ages.	SOX3 SALL3 CASZ1	2.29e-04	30	138	3	35320729
Pubmed	Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells.	ARX GLI2 PITX3	2.29e-04	30	138	3	25804738
Pubmed	Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12).	FOXF1 FOXD1	2.32e-04	6	138	2	8825632
Pubmed	Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network.	HCN4 IRX3	2.32e-04	6	138	2	21825130
Pubmed	Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats.	KMT2D ATXN2	2.32e-04	6	138	2	8896557
Pubmed	Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility.	AIRE NFKB2	2.32e-04	6	138	2	33107914
Pubmed	The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis.	EGR3 PRKD1	2.32e-04	6	138	2	18059339
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	ZSWIM8 VPS11 SZT2 USP11 USP5	3.11e-04	147	138	5	29576527
Pubmed	Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-kappaB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes.	KMT2D NFKB2	3.24e-04	7	138	2	19219072
Pubmed	Deletion of ultraconserved elements yields viable mice.	SOX3 ARX	3.24e-04	7	138	2	17803355
Pubmed	A double-deletion mutation in the Pitx3 gene causes arrested lens development in aphakia mice.	NFKB2 PITX3	3.24e-04	7	138	2	11247667
Pubmed	FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine.	GLI2 FOXF1	3.24e-04	7	138	2	19049965
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	WHRN PTF1A PATZ1 ZFPM1 NACAD CASZ1	3.49e-04	233	138	6	37704626
Pubmed	ISLET1-Dependent β-Catenin/Hedgehog Signaling Is Required for Outgrowth of the Lower Jaw.	FOXD2 FOXF1 FOXD1	3.65e-04	35	138	3	28069742
Pubmed	Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon.	ARX IRX3 FOXD1	3.97e-04	36	138	3	18094027
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	ZSWIM8 ARX TRIOBP TNIP1 CCDC88B TLE5 ARHGAP44 LTBP1 ANKS3	4.17e-04	560	138	9	21653829
Pubmed	GLI transcriptional repression is inert prior to Hedgehog pathway activation.	GLI2 FOXF1	4.31e-04	8	138	2	35145123
Pubmed	Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom).	MLLT6 DOT1L	4.31e-04	8	138	2	20203130
Pubmed	Functional Equivalence of the SOX2 and SOX3 Transcription Factors in the Developing Mouse Brain and Testes.	SOX3 EGR3	4.31e-04	8	138	2	28515211
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	KCTD12 TEX2 TMEM121B RTN4 CASKIN1 FMN2 AGAP2	4.91e-04	347	138	7	17114649
Pubmed	Interaction network of human early embryonic transcription factors.	BCL9L BICRA MBD6 ZNF503 TAF3 KMT2D TLE5	5.26e-04	351	138	7	38297188
Pubmed	An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution.	FOXD2 FOXD1	5.53e-04	9	138	2	12412011
Pubmed	Fine mapping of polymorphic alcohol-related quantitative trait loci candidate genes using interval-specific congenic recombinant mice.	MAPK8IP1 SIRPB1	5.53e-04	9	138	2	12436047
Pubmed	Genetic chimeras reveal the autonomy requirements for Vsx2 in embryonic retinal progenitor cells.	PTF1A BHLHE22	5.53e-04	9	138	2	25927996
Pubmed	Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube.	ARX GLI2	5.53e-04	9	138	2	20516201
Pubmed	Purkinje cells originate from cerebellar ventricular zone progenitors positive for Neph3 and E-cadherin.	PTF1A SKOR2	5.53e-04	9	138	2	20004188
Pubmed	Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.	E2F3 KMT2D	5.53e-04	9	138	2	16951254
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	LIMD1 TEX2 PATZ1 SIK1 DENND1A MEPCE NAV1 FMN2 TSC22D4 KLC3 MTSS2	6.69e-04	861	138	11	36931259
Pubmed	Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression.	CD248 KLF14 SIK1	6.72e-04	43	138	3	26839965
Pubmed	Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2.	FOXD2 FOXD1	6.89e-04	10	138	2	26071365
Pubmed	Patched1 patterns Fibroblast growth factor 10 and Forkhead box F1 expression during pulmonary branch formation.	GLI2 FOXF1	6.89e-04	10	138	2	28939119
Pubmed	Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks.	GLI2 FOXD1	6.89e-04	10	138	2	33006313
Pubmed	Fusion of lung lobes and vessels in mouse embryos heterozygous for the forkhead box f1 targeted allele.	GLI2 FOXF1	6.89e-04	10	138	2	11943666
Pubmed	CCND2, CTNNB1, DDX3X, GLI2, SMARCA4, MYC, MYCN, PTCH1, TP53, and MLL2 gene variants and risk of childhood medulloblastoma.	KMT2D GLI2	6.89e-04	10	138	2	26290144
Pubmed	Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.	TSC22D2 TSC22D4	6.89e-04	10	138	2	23382044
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	UBE4B TSC22D2 ARHGAP44 ULK2	7.46e-04	102	138	4	9734811
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	SZT2 NTN3 SIK1 ANO8 KLF16 EHBP1L1 TLE5 TMEM259 ARHGAP44 MEPCE MLLT6 ELK1	7.93e-04	1021	138	12	26760575
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	WHRN RELCH LRFN1 PATZ1 DENND1A CEP43 AP2A2 PRCC ARHGAP44 NAV1 PRKD1 ANKS3 RUSF1 KLC3	8.01e-04	1321	138	14	27173435
Pubmed	Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.	TSC22D2 TSC22D4	8.40e-04	11	138	2	22510880
Pubmed	Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases.	MAPK8IP1 ELK1	8.40e-04	11	138	2	16533805
Pubmed	CPLANE protein INTU regulates growth and patterning of the mouse lungs through cilia-dependent Hh signaling.	GLI2 FOXF1	8.40e-04	11	138	2	39029571
Pubmed	Sonic hedgehog regulation of Foxf2 promotes cranial neural crest mesenchyme proliferation and is disrupted in cleft lip morphogenesis.	FOXF1 FOXD1	8.40e-04	11	138	2	28506991
Interaction	TOP3B interactions	ZXDC KCTD12 TRNP1 LRFN1 UBE4B SZT2 BICRA SIAH2 ZFPM1 ATG2A MBD6 DENND1A CASZ1 ANO8 CRKL CABLES1 ZNF503 HIVEP3 SEPHS2 EHBP1L1 KMT2D SSH1 ATXN2 TMEM259 CASKIN1 NFKB2 ARHGAP44 NAV1 MLLT6 DOT1L SNAPC4 ULK2 ARHGAP33	3.02e-10	1470	133	33	int:TOP3B
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZXDC ZNF444 SALL3 PATZ1 KLF14 ZFPM1 ZNF467 CASZ1 ZNF503 HIVEP3 KLF16 EGR3 GLI2	3.73e-05	718	87	13	28
GeneFamily	Ataxins\|Trinucleotide repeat containing	KMT2D ATXN2 BHLHE22	2.29e-04	25	87	3	775
GeneFamily	PHD finger proteins	AIRE TAF3 KMT2D MLLT6	9.33e-04	90	87	4	88
GeneFamily	Forkhead boxes	FOXD2 FOXF1 FOXD1	1.16e-03	43	87	3	508
Coexpression	GSE36009_UNSTIM_VS_LPS_STIM_DC_DN	HIVEP3 KLF16 EHBP1L1 DCAF10 ATXN2 NFKB2 MEPCE MLLT6 TSC22D4	1.06e-06	200	136	9	M8774
Coexpression	THAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_28DY_DN	ZXDC KIF21B RELCH BICRA AIRE ATG2A MBD6 ZNF467 SNX29 CASZ1 ZNF503 EHBP1L1 SEC24C TMEM259 CBX6 OSBPL7 RUSF1 ARHGAP33	1.09e-06	905	136	18	M40865
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3	SOX3 TRNP1 SALL3 CD248 HCN4 ARX EMILIN2 IRX3 CASZ1 LFNG ZNF503 EGR3 GLI2 BHLHE22 PITX3 DMRTA2 FHDC1 FOXF1 FOXD1	3.00e-06	1074	136	19	M1941
Coexpression	CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_UP	ZSWIM8 ZNF444 PATZ1 DUSP8 NACA TNIP1 ZNF467 DENND1A LFNG KMT2D ATXN2	5.63e-06	385	136	11	M2840
Coexpression	GSE19198_1H_VS_6H_IL21_TREATED_TCELL_UP	HNF1A HCN4 SLC10A4 CBX6 BHLHE22 PVRIG ULK2 FOXF1	6.49e-06	188	136	8	M7224
Coexpression	GSE27786_LIN_NEG_VS_NKTCELL_DN	KCTD12 ZSWIM8 LIMD1 BICRA TNIP1 CCDC88B KMT2D IRF2BPL	1.02e-05	200	136	8	M4788
Coexpression	HE_LIM_SUN_FETAL_LUNG_C1_GHRL_POS_NE_PRECURSOR_CELL	MAPK8IP1 TRNP1 NAAA TEX2 ARX CBFA2T3 NACAD CASZ1 KLF16 FAM222A NAV1	1.55e-05	429	136	11	M45694
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HNBML5	KIF21B TMEM121B CASZ1 HIVEP3 NRXN2 CASKIN1 BHLHE22 NAV1 FMN2 IRF2BPL DOT1L	3.24e-05	465	136	11	M39066
Coexpression	GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN	ZNF444 SZT2 BICRA KLF16 KMT2D TMEM259 DOT1L SNAPC4 MTSS2	7.07e-05	338	136	9	M17094
Coexpression	HE_LIM_SUN_FETAL_LUNG_C1_INTERM_NEUROENDOCRINE_CELL	MAPK8IP1 TRNP1 NAAA CBFA2T3 NACAD CASZ1 HIVEP3 NAV1	8.20e-05	268	136	8	M45696
Coexpression	GSE5542_UNTREATED_VS_IFNA_AND_IFNG_TREATED_EPITHELIAL_CELLS_6H_DN	ATG2A MBD6 DENND1A EGR3 CBX6 OSBPL7 AGAP2	8.36e-05	199	136	7	M6519
Coexpression	GSE30083_SP2_VS_SP4_THYMOCYTE_UP	WHRN LRFN1 PTF1A ARX KLF14 ZNF467 HIVEP3	8.63e-05	200	136	7	M5034
Coexpression	GSE40655_FOXO1_KO_VS_WT_NTREG_UP	KCTD12 SZT2 KMT2D SEC24C OSBPL7 MLLT6 SNAPC4	8.63e-05	200	136	7	M9439
Coexpression	GSE27786_LIN_NEG_VS_BCELL_DN	FOXD2 KIF21B ZSWIM8 SZT2 SNX29 KMT2D AGAP2	8.63e-05	200	136	7	M4768
Coexpression	GSE24210_CTRL_VS_IL35_TREATED_TCONV_CD4_TCELL_UP	KCTD12 TRIOBP CBFA2T3 SNX29 AP2A2 TLE5 IRF2BPL	8.63e-05	200	136	7	M7841
Coexpression	THAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_7DY_DN	ZXDC KIF21B RELCH BICRA AIRE ATG2A MBD6 CASZ1 CBX6 OSBPL7 RUSF1 ARHGAP33	1.20e-04	634	136	12	M40866
Coexpression	TABULA_MURIS_SENIS_BRAIN_NON_MYELOID_NEURON_AGEING	KIF21B MAPK8IP1 BCL9L VPS11 EPB41L4B TNIP1 SIRPB1 NRXN2 TLE5 TMEM259 FMN2 LTBP1 ULK2 UBE2Z MTSS2	1.34e-04	954	136	15	MM3689
Coexpression	GSE7509_FCGRIIB_VS_TNFA_IL1B_IL6_PGE_STIM_DC_DN	WHRN AIRE MBD6 SNX29 SNAPC4 ANKS3	1.56e-04	154	136	6	M6824
Coexpression	HE_LIM_SUN_FETAL_LUNG_C1_GHRL_POS_NEUROENDOCRINE_CELL	MAPK8IP1 TRNP1 NAAA ARX CASZ1 HIVEP3	1.62e-04	155	136	6	M45695
CoexpressionAtlas	EB amniotic fluid MSC_vs_EB blastocyst-Confounder_removed-fold2.0_adjp0.05	KIF21B MAPK8IP1 SLC22A23 DUSP8 ARX SIK1 CBFA2T3 GDF1 NACAD CASZ1 LFNG ANO8 NRXN2 EGR3 CASKIN1 PVRIG DMRTA2 ARHGAP33 AGAP2	1.58e-07	727	134	19	PCBC_ratio_EB amniotic fluid MSC_vs_EB blastocyst_cfr-2X-p05
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCL9L SIK1 IRX3 KLF16 TLE5 EGR3 CBX6 KLC3 MTSS2	7.04e-09	186	138	9	bd1185592aedebccd1007dbf2dd2f549fcdf9f42
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	KCTD12 SLC22A23 LGR4 CASZ1 ATRNL1 LTBP1 FHDC1 FOXF1	1.34e-07	188	138	8	3004e961d214919e08c7cd5f10c3de5cf85b35a3
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	KCTD12 SLC22A23 CASZ1 ATRNL1 LTBP1 FHDC1 FOXF1	1.70e-06	183	138	7	e84539978ab4de42e19186aed00f24bb50cbc21f
ToppCell	3'-Adult-LargeIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRNP1 PNMT ARX NACAD LFNG EGR3 FAM222A	1.70e-06	183	138	7	49f3ddc1c7c04b4ca837dbd6dad995add82941d6
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SIK1 IRX3 KLF16 TLE5 CBX6 KLC3 MTSS2	2.10e-06	189	138	7	965e0e388251e7318f8b463816dc96ccb4658677
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NAAA EMILIN2 SIAH2 E2F3 DENND1A SNX29 AP2A2	2.50e-06	194	138	7	663e7e7fe48157e808b4f1a0ea6ad41944e857a2
ToppCell	3'-Child04-06-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DOCK8-AS1 PNMT TRIOBP SSH1 ALPK3 MTSS2	1.67e-05	173	138	6	85083b9ce20351dd69aa2327ad087b848b4307ff
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEX2 SIK1 CBFA2T3 SNX29 HIVEP3 NRXN2	2.09e-05	180	138	6	df60970520fba2ac0639faa54096766d07418ca4
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXD2 PNMT HCN4 DMRTA2 KLC3 FOXD1	2.09e-05	180	138	6	d553aba594f5304f1c09ff9c6d49b64cd7ee7850
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HNF1A SZT2 ARX PRCC FOXD1 AGAP2	2.52e-05	186	138	6	bdc87e4631a8ea73e262e541aa84a28f24c94b00
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SALL3 RTN4 LGR4 CASZ1 ARHGAP44 DOT1L	2.59e-05	187	138	6	f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCell	COVID-19-kidney-DCT\|kidney / Disease (COVID-19 only), tissue and cell type	TRABD2B SALL3 LGR4 TSC22D2 CASZ1 ALPK3	2.67e-05	188	138	6	df1fd0819d301679f3c9ea404e942e39095912eb
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	KCTD12 LGR4 CASZ1 ATRNL1 FHDC1 FOXF1	2.75e-05	189	138	6	f75cebd4c3e54e297557449ba67ccc8d1a2a14f5
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	PNMT DUSP8 CBX6 ATRNL1 LTBP1 FOXF1	2.84e-05	190	138	6	938d1f66094b1c94606e0d40213a39e5112f3322
ToppCell	Adult-Immune-monocyte-D175\|Adult / Lineage, Cell type, age group and donor	EMILIN2 CBFA2T3 DENND1A EHBP1L1 EGR3 NAV1	2.92e-05	191	138	6	cbebb4d9550fdcd606cb3685ac9546c6b73fd422
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD16\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NAAA EMILIN2 CBFA2T3 DENND1A LFNG EHBP1L1	3.67e-05	199	138	6	ac866ae110967c5867ff4601939b79861d43df54
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Monocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NAAA EMILIN2 CBFA2T3 DENND1A LFNG EHBP1L1	3.78e-05	200	138	6	fd72fe6565e2f4885481991492d58c323ab1ad40
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	KIF21B ARX NACAD HIVEP3 NRXN2 ATRNL1	3.78e-05	200	138	6	bad32a95b759fad509401b07bc96a56687c2a592
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate\|5w / Sample Type, Dataset, Time_group, and Cell type.	KIF21B ARX NRXN2 TLE5 NAV1 GRIN3A	3.78e-05	200	138	6	c92e4fc0442404481fcac623d691dae6215b852d
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Intermediate\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	KCTD12 DUSP8 TMEM259 FMN2 LTBP1 AGAP2	3.78e-05	200	138	6	a3fcd901cb281920f1bafdfd676399a6dc37355e
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Monocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NAAA EMILIN2 CBFA2T3 DENND1A LFNG EHBP1L1	3.78e-05	200	138	6	8872d5fa101d413fb43b4231d476878678543035
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal-GABAergic_neurons\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	KCTD12 MAPK8IP1 ARX NRXN2 ATRNL1 AGAP2	3.78e-05	200	138	6	c6bbd33bca86ac7a76a7ba704b3e141237d04549
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD16\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NAAA EMILIN2 CBFA2T3 DENND1A LFNG EHBP1L1	3.78e-05	200	138	6	fc061de0db2e8b5ca47f5e2a1e861018e7f1b582
Disease	mean platelet volume	TEX2 SLC22A23 NACA SIRPB1 TSC22D2 CBFA2T3 LFNG CRKL CABLES1 MSANTD1 SSH1 TLE5 ATXN2 LTBP1 ULK2	7.61e-05	1020	136	15	EFO_0004584
Disease	Metastatic melanoma	SIK1 ALPK3 PRKD1 ULK2	1.14e-04	54	136	4	C0278883
Disease	sexual dimorphism measurement	HNF1A CD248 RTN4 KLF14 LGR4 CABLES1 EHBP1L1 GLI2 CASKIN1 ALPK3 LTBP1 POC5 DOT1L ANKS3 AGAP2	1.85e-04	1106	136	15	EFO_0021796
Disease	immune system disease	TNIP1 ATXN2 C6orf15	2.88e-04	28	136	3	EFO_0000540
Disease	trypsin-1 measurement	CBFA2T3 MAMSTR	3.13e-04	6	136	2	EFO_0020790
Disease	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 1	ARX SIK1	3.13e-04	6	136	2	C3463992
Disease	primary biliary cirrhosis	KIF21B SLC22A23 CCDC88B CEP43 ATXN2	3.87e-04	133	136	5	EFO_1001486
Disease	X-linked infantile spasms	ARX SIK1	5.80e-04	8	136	2	C4552072
Disease	hair colour measurement	DOCK8-AS1 SLC22A23 LGR4 SIK1 ZFPM1 ATG2A CBFA2T3 DENND1A KMT2D FMN2	5.84e-04	615	136	10	EFO_0007822
Disease	cholesteryl ester measurement, high density lipoprotein cholesterol measurement	HNF1A VPS11 KLF14 TSC22D2 SNX29 ATXN2 POC5	6.30e-04	312	136	7	EFO_0004612, EFO_0010351
Disease	total cholesterol measurement, high density lipoprotein cholesterol measurement	HNF1A VPS11 KLF14 TSC22D2 SNX29 ATXN2 POC5	6.67e-04	315	136	7	EFO_0004574, EFO_0004612
Disease	level of Sterol ester (27:1/16:1) in blood serum	HNF1A DENND1A	7.43e-04	9	136	2	OBA_2045190
Disease	Paroxysmal atrial fibrillation	HCN4 UBE4B NACA CASZ1 IRF2BPL	7.99e-04	156	136	5	C0235480
Disease	familial atrial fibrillation	HCN4 UBE4B NACA CASZ1 IRF2BPL	7.99e-04	156	136	5	C3468561
Disease	Persistent atrial fibrillation	HCN4 UBE4B NACA CASZ1 IRF2BPL	7.99e-04	156	136	5	C2585653
Disease	Atrial Fibrillation	HCN4 UBE4B NACA CASZ1 IRF2BPL	8.95e-04	160	136	5	C0004238
Disease	Microphthalmos	KMT2D PITX3	1.13e-03	11	136	2	C0026010
Disease	rheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement	AIRE TNIP1 CCDC88B HIVEP3 ATXN2	1.17e-03	170	136	5	EFO_0000685, EFO_0007791, EFO_0007837
Disease	Gastrointestinal Stromal Sarcoma	SALL3 GLI2 FOXF1	1.34e-03	47	136	3	C3179349
Disease	Colorectal Carcinoma	RELCH CCDC9B SALL3 CD248 RTN4 CBFA2T3 KCNH4 CABLES1 HIVEP3 PRKD1	1.58e-03	702	136	10	C0009402
Disease	Genetic chronic primary adrenal insufficiency	AIRE ATXN2	1.59e-03	13	136	2	Orphanet_101960
Disease	colon carcinoma (is_marker_for)	CRKL KMT2D	1.59e-03	13	136	2	DOID:1520 (is_marker_for)
Disease	Gastrointestinal Stromal Tumors	SALL3 GLI2 FOXF1	1.60e-03	50	136	3	C0238198
Disease	atrial fibrillation	HCN4 UBE4B BICRA NACA HS1BP3 CASZ1 PITX3	1.71e-03	371	136	7	EFO_0000275
Disease	cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	HNF1A PNMT KLF14 TSC22D2 ATXN2 POC5	1.81e-03	276	136	6	EFO_0004612, EFO_0020943
Disease	C-X-C motif chemokine 11 measurement	NAAA ATXN2	1.85e-03	14	136	2	EFO_0008057
Disease	Situs ambiguus	BCL9L GDF1	2.13e-03	15	136	2	C0266642
Disease	African Burkitt's lymphoma	SALL3 BBC3	2.13e-03	15	136	2	C0343640
Disease	Burkitt Leukemia	SALL3 BBC3	2.13e-03	15	136	2	C4721444
Disease	DiGeorge Syndrome	CRKL SEC24C	2.43e-03	16	136	2	C0012236
Disease	CONOTRUNCAL ANOMALY FACE SYNDROME	CRKL SEC24C	2.43e-03	16	136	2	C0795907
Disease	galectin-3 measurement	HNF1A MAMSTR	2.43e-03	16	136	2	EFO_0008137
Disease	Early infantile epileptic encephalopathy with suppression bursts	ARX SIK1	2.43e-03	16	136	2	C0393706
Disease	Shprintzen syndrome	CRKL SEC24C	2.43e-03	16	136	2	C0220704
Disease	Sjogren syndrome	TNIP1 ATXN2 PRCC	2.71e-03	60	136	3	EFO_0000699
Disease	free cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	HNF1A PNMT KLF14 EMILIN2 ATXN2 POC5	2.88e-03	303	136	6	EFO_0004612, EFO_0020945
Disease	sarcoidosis	CCDC88B ATXN2 C6orf15	3.25e-03	64	136	3	MONDO_0019338
Disease	ethylmalonate measurement	HNF1A CBFA2T3	3.79e-03	20	136	2	EFO_0020009
Disease	waist circumference	KLF14 TSC22D2 CABLES1 FAM222A NAV1 PRKD1 POC5	3.84e-03	429	136	7	EFO_0004342
Disease	Crohn's disease	KIF21B SLC22A23 CCDC88B CEP43 ATXN2 C6orf15 MAMSTR	4.45e-03	441	136	7	EFO_0000384
Disease	diet measurement, fasting blood insulin measurement	SLC22A23 SNX29	4.59e-03	22	136	2	EFO_0004466, EFO_0008111

Protein segments in the cluster

Peptide	Gene	Start	Entry
APTAPPAVTAALGGS	BBC3	61	Q9BXH1
TGSPLLLTPSPFGGA	ERFL	141	A0A1W2PQ73
AGPPADALSGLPSKS	FAM222A	381	Q5U5X8
GGPAAPSLPSAQLAG	MLLT6	491	P55198
SGSGLQAPGPALTPS	ELK1	341	P19419
ATPTLATPACPGALG	CCDC187	876	A0A096LP49
SPGEAPLAGAAPSLQ	CCDC88B	436	A6NC98
SPGKAEASAPGPGLL	CBX6	246	O95503
EASAPGPGLLLAAPA	CBX6	251	O95503
AALAALGAPGPAPTA	CASZ1	1741	Q86V15
DSPSGAALGLSSPSP	DUSP8	426	Q13202
GGDPSLSSLPAGAAL	BHLHE22	111	Q8NFJ8
SPAPTAAPTALGEAG	CD248	661	Q9HCU0
SLPGTGLTASPKAGP	ALPK3	1071	Q96L96
SSAGAGGAEPPALSP	AGAP2	81	Q99490
SALGNGSLAPGLPAP	CALHM1	136	Q8IU99
GSPASLTPGAEPATL	DOT1L	951	Q8TEK3
GPEAAGLSSPLSFPS	DOT1L	1341	Q8TEK3
AAVPPGSLLSGPGLA	DOT1L	1431	Q8TEK3
PGAATAAAATATGPP	DMRTA2	11	Q96SC8
ASGGPQAAAPEAPSL	ATG2A	906	Q2TAZ0
AAPAALTPRGTASPG	AIRE	141	O43918
SPSADLLGLGAAPPA	AP2A2	656	O94973
SLAAAGAGATTRPPP	ANO8	996	Q9HCE9
PLPASAAKAGGPGAS	FOXD1	341	Q16676
LAPASSAGPGPGLSL	SLC10A4	36	Q96EP9
GLDPGSAGSLSPQDP	RELCH	46	Q9P260
GSAQSPPLSPLALGI	FHDC1	656	Q9C0D6
GPGPSLSALSHPTGA	MSANTD1	6	Q6ZTZ1
LLPSPPAAVGGASAT	POC5	416	Q8NA72
AVAGLPSGSAGPSPA	CASKIN1	1286	Q8WXD9
EGPGAPPFLASSLLS	MBD6	311	Q96DN6
AAAAAALVPGSGPGP	PRKD1	21	Q15139
SGPGPGAAAAPHLLA	KLF16	66	Q9BXK1
AASSPSSGRAPGAAP	KLF16	106	Q9BXK1
ALRSLAGPAGAAPAP	LFNG	41	Q8NES3
GAAKPPLAASTGAPG	LIMD1	101	Q9UGP4
PLPSALQGPSGSLSA	MEPCE	331	Q7L2J0
LQGPSGSLSAPPAAS	MEPCE	336	Q7L2J0
AGAGLSAASPPAAPR	NAAA	21	Q02083
GGAASPPAASPFLGL	MAPK8IP1	11	Q9UQF2
TSAPPTLALVPGGAA	LRFN1	681	Q9P244
GSGLLASPAAAPSPS	ATXN2	201	Q99700
ALPVALSGSGGPPAL	GDF1	301	P27539
GSAPAASPALASPEG	CCDC9B	381	Q6ZUT6
ALPPAAPSGRGAAAS	IRF2BPL	526	Q9H1B7
SAAAGAPSRASPGVP	LTBP1	66	Q14766
PASTAGLPTAGLPTA	MTSS2	536	Q765P7
SSGSDAPLPAPGLSH	C19orf85	146	A0A1B0GUS0
LGLPGAPESSTASAP	DCAF10	71	Q5QP82
SLGASPAAPAFGGSP	KIF21B	516	O75037
GPLASADLGLAPTPS	ZFPM1	411	Q8IX07
SGLSLPPAEPAGHSG	EHBP1L1	476	Q8N3D4
PSLSPSLSPALAGQG	KCNH4	776	Q9UQ05
PAAAGGAGLQPLASP	EP400P1	231	Q6ZTU2
SAAGGPLPPVSTLTA	HNF1A	371	P20823
LGSAGPSGAAPPLCA	LGR4	16	Q9BXB1
PPGADTSALAAPSAG	GLI2	701	P10070
DLPAPLGAPNTGTAG	KLC3	406	Q6P597
LPAVSGSPGAAITPL	CRKL	216	P46109
SLGPSLPVGAASPSE	CBFA2T3	616	O75081
SGSHGSLLLPPASSP	HCN4	1046	Q9Y3Q4
AGLGDLPLLPFSSPS	GRIN3A	156	Q8TCU5
AAPLALAPPSSGGLG	PTF1A	76	Q7RTS3
AFSPSLPPCLGSAEG	PCDHA13	771	Q9Y5I0
LGDLGPALGSPFSPQ	PATZ1	636	Q9HBE1
TAGTLFAALSPGPPA	NTN3	11	O00634
GATGAPGVLFAPSAP	NRXN2	496	P58401
LGAGGAPASATPTPA	ARHGAP33	811	O14559
AAALAPGSGPLPGES	C6orf15	141	Q6UXA7
LLLPAACESGGPTPS	HS1BP3	281	Q53T59
VNPALPLSPTGLAGS	BPIFA1	36	Q9NP55
SGAVAAGPLLPSAPG	E2F3	76	O00716
LAGPSAGAAARPAAP	DOCK8-AS1	56	Q5T8R8
GLAAGSGPCLPQPSS	CABLES1	131	Q8TDN4
APPLKSGLSSLAGAP	CEP43	286	O95684
GGAPSASSAPPVSLA	EGR3	366	Q06889
PSSAPGPALLGEAAA	BCL9L	371	Q86UU0
SGAPPPGQSGLAIAS	ATRNL1	1331	Q5VV63
GSPGPVAAAPSSLVA	TMEM259	511	Q4ZIN3
PALTPSSGPGSAALT	MAMSTR	276	Q6ZN01
PGAATLGLAVPPADS	ANKS3	591	Q6ZW76
ASLPPSGAPLGLSTF	ARX	451	Q96QS3
GAPPASLGPAFASGL	DENND1A	856	Q8TEH3
APSPGAGGAAPHLLA	KLF14	71	Q8TD94
NTGAELSPPGAAALP	EMILIN2	511	Q9BXX0
LSPPGAAALPGVSGS	EMILIN2	516	Q9BXX0
SGQPLAVAPGLGSSP	BICRA	321	Q9NZM4
LPGHGPLSSSAPGAS	BICRA	1221	Q9NZM4
AQGPDAPAAASLPGS	FMN2	386	Q9NZ56
SGAVAPAPPSSGLGF	SEC24C	146	P53992
PAAAIAGSGPAAPAA	SALL3	271	Q9BXA9
STPPALAPGSLLGAA	SALL3	341	Q9BXA9
LAPGSLLGAAPGLPS	SALL3	346	Q9BXA9
GAPTSLGSPGLPAVS	SALL3	626	Q9BXA9
SSSALPAAPGGSVFP	EPB41L4B	46	Q9H329
PSGGAAGPLLTPSQS	KCTD12	186	Q96CX2
SAAAAPGTVPGPGAL	PITX3	201	O75364
LPTAATASALPGLGP	OSBPL7	166	Q9BZF2
GSPPGAAVAPSALQL	IRX3	371	P78415
LSPPAAGTAAGLPTA	FOXD2	371	O60548
GSPAGGAKTPLAPLA	NAV1	151	Q8NEY1
SSVPASPLLPTGAGG	FOXF1	241	Q12946
GASGAPSPPLSGLQA	RUSF1	61	Q96GQ5
AGLSAAPVPTAPAAG	RTN4	61	Q9NQC3
ALLPSPGPAASGASA	TAF3	826	Q5VWG9
SPGEASGLILAPGPA	SZT2	3231	Q5T011
PSGLLPPGAAAAAAA	SOX3	226	P41225
PGHGSPLSSLLPSAS	SNX29	446	Q8TEQ0
SGPALGGLFASLPAP	PRCC	31	Q92733
SEAGAPPGSAGPLLL	TMEM121B	371	Q9BXQ6
LAAAATSAPAPGAPG	TSC22D2	121	O75157
ASLGLGAPTPPSGLS	TSC22D4	131	Q9Y3Q8
SLPPGDAAASAPLGG	SLC22A23	26	A1A5C7
GPGAAPLPSTLLTSG	SIK1B	691	A0A0B4J2F2
GPGAAPLPSTLLTSG	SIK1	691	P57059
APPAAATISAAGPGS	SIAH2	31	O43255
ATVAGGCLLPPSPSG	WHRN	696	Q9P202
DSPAAPALSPSGLGL	ARHGAP44	566	Q17R89
DLAFLAPSPSPGSSG	TRIOBP	1236	Q9H2D6
GSNTAPGPALASAAP	SIRPB1	356	Q5TFQ8
SGPGAGAALEPPASL	SSH1	726	Q8WYL5
PPSLPAVSAGTGLLS	TLE5	151	Q08117
GAGSPAPLPADALVS	PNMT	166	P11086
PPTAFGSPEGAGALL	TNIP1	436	Q15025
ASQEAGLPAGAGPSP	SEPHS2	96	Q99611
APGLPAFLAAPGTTS	ZNF444	166	Q8N0Y2
PLSNDGAAPGATPAS	VPS11	21	Q9H270
ALSAPPGPATAGAAA	ZXDC	146	Q2QGD7
GPASSSAPTLGLLPA	TRABD2B	486	A6NFA1
PIAASAPGPSQSLGL	UBE4B	41	O95155
GSLSLTGPSAPAPVA	HIVEP3	1016	Q5T1R4
GSAVPGPSASLAPSA	TMUB2	246	Q71RG4
PGLPPSAAAHGAALL	UBE2Z	66	Q9H832
PPSALGCALGESPAL	SKOR2	491	Q2VWA4
GFGSSPPGAEAAPSL	ULK2	776	Q8IYT8
GPSAPGALQPLTSGS	ZSWIM8	1046	A7E2V4
AAAGATPPSLAGHPL	ZNF503	486	Q96F45
LGGPAASLSPPKGSS	SNAPC4	591	Q5SXM2
PLAVSPGSSSSGPLA	TEX2	131	Q8IWB9
ACGSLPPSSDPGLSA	PVRIG	146	Q6DKI7
AGSSAPGSPAALPDS	nan	126	Q8N6K4
SPPLPDAAGASAGAA	TRNP1	51	Q6NT89
LLSPAGSSGAPASPA	USP11	936	P51784
FANPLILPGSSGPGS	USP5	701	P45974
LEPGAPGALSGLALS	ZNF467	136	Q7Z7K2
LSLPAAPGGRDPSAS	UNQ6190/PRO20217	16	Q6UXQ8
ASASFPGSEPLLGSP	KMT2D	1216	O14686
ALSGRASPVPAPSSG	KIAA1522	856	Q9P206
GPDPSAPGTLAGAAL	NACAD	1226	O15069
SSGTALPLGTAPEAP	NACA	86	E9PAV3
PSPAGPGLSLGDTAL	NFKB2	761	Q00653