Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Channel_four-helix_dom	CACNA1H TPTE2	4.55e-03	57	33	2	IPR027359
Domain	-	CACNA1H TPTE2	4.55e-03	57	33	2	1.20.120.350
Pathway	REACTOME_NEDDYLATION	UBE2F DCAF17 CAND1 SKP1 FBXW12	7.43e-05	245	26	5	M27822
Pubmed	The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor.	SKP1 FBXW12	2.78e-06	3	34	2	26171402
Pubmed	Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange.	CAND1 SKP1	9.26e-06	5	34	2	37339624
Pubmed	Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF.	ING1 KAT8	1.39e-05	6	34	2	22072714
Pubmed	Impaired DNA damage checkpoint response in MIF-deficient mice.	CAND1 SKP1	1.94e-05	7	34	2	17290223
Pubmed	The steady-state repertoire of human SCF ubiquitin ligase complexes does not require ongoing Nedd8 conjugation.	CAND1 SKP1	1.94e-05	7	34	2	21169563
Pubmed	Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1.	CAND1 SKP1	2.59e-05	8	34	2	12684064
Pubmed	CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.	CAND1 SKP1	2.59e-05	8	34	2	12504026
Pubmed	An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases.	DCAF17 CAND1 SKP1	2.67e-05	59	34	3	19295130
Pubmed	NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases.	CAND1 SKP1	4.15e-05	10	34	2	12504025
Pubmed	Regulation of cullin RING E3 ubiquitin ligases by CAND1 in vivo.	CAND1 SKP1	4.15e-05	10	34	2	21249194
Pubmed	Poly r(C) binding protein (PCBP) 1 expression is regulated by the E3 ligase UBE4A in thyroid carcinoma.	FOXN2 SKP1	5.07e-05	11	34	2	28963376
Pubmed	TIP120A associates with cullins and modulates ubiquitin ligase activity.	CAND1 SKP1	5.07e-05	11	34	2	12609982
Pubmed	Bone morphogenetic protein (BMP) 7 expression is regulated by the E3 ligase UBE4A in diabetic nephropathy.	FOXN2 SKP1	5.07e-05	11	34	2	30663414
Pubmed	TAK1 Is a Novel Target in Hepatocellular Carcinoma and Contributes to Sorafenib Resistance.	SKP1 FBXW12	7.19e-05	13	34	2	33962073
Pubmed	Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism.	CAND1 SKP1	7.19e-05	13	34	2	22767593
Pubmed	Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression.	CAND1 SKP1	7.19e-05	13	34	2	29499133
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	INTS9 CAND1 RHOD SKP1 FGD4 LIN9 AQR KAT8	7.71e-05	1497	34	8	31527615
Pubmed	Herpes virus deneddylases interrupt the cullin-RING ligase neddylation cycle by inhibiting the binding of CAND1.	CAND1 SKP1	8.38e-05	14	34	2	22474075
Pubmed	The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7.	CAND1 SKP1	1.57e-04	19	34	2	22405651
Pubmed	COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.	CAND1 SKP1	1.74e-04	20	34	2	21778237
Pubmed	Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling.	UBE2F CAND1	2.12e-04	22	34	2	30587576
Pubmed	Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.	SKP1 TTLL9	2.74e-04	25	34	2	29593216
Pubmed	Cryo-EM structure of a human spliceosome activated for step 2 of splicing.	CDC40 AQR	3.97e-04	30	34	2	28076346
Pubmed	A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation.	CYBB FGD4	4.24e-04	31	34	2	32245826
Pubmed	A family of mammalian F-box proteins.	SKP1 FBXW12	7.79e-04	42	34	2	10531037
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	CAND1 CDC40 ZNF512 DHX37 AQR	8.04e-04	759	34	5	35915203
Pubmed	EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.	ZNF512 SKP1	8.55e-04	44	34	2	27505670
Disease	Squamous cell carcinoma of the head and neck	MET ING1	1.55e-03	52	33	2	C1168401
Disease	Autistic Disorder	MET CACNA1H KAT8	3.07e-03	261	33	3	C0004352
Disease	Hereditary Diffuse Gastric Cancer	MET RARRES1 ING1	4.24e-03	293	33	3	C1708349
Disease	Stomach Neoplasms	MET RARRES1 ING1	4.41e-03	297	33	3	C0038356
Disease	Malignant neoplasm of stomach	MET RARRES1 ING1	4.53e-03	300	33	3	C0024623

Protein segments in the cluster

Peptide	Gene	Start	Entry
PWHYIVTPNKKKQKG	DCAF17	301	Q5H9S7
PYCAEKKATPIKLIW	GPR15	181	P49685
LACKYWAPHIKKKSP	AQR	26	O60306
WLCHNKQSKVYLPEP	INTS9	346	Q9NV88
ALPPEKKWQIYCSKK	DAAM2	71	Q86T65
CKVGSYLKSPKFPIW	MINDY3	266	Q9H8M7
NLLKLPKAHKWCIYE	LIN9	111	Q5TKA1
YGLKKPNKLTHLCWP	IL31RA	541	Q8NI17
VKYWKGQHVICVTPK	KAT8	406	Q9H7Z6
YKKPPITVDSVCLKW	KAT8	431	Q9H7Z6
KPYVENIWALLLKHC	CAND1	926	Q86VP6
QYGIVLLHCSPDKKW	FBXW12	231	Q6X9E4
KAWCVIPKQDPLVLY	FGD4	661	Q96M96
PCIVCPWHKYKITLA	RFESD	76	Q8TAC1
CKEPVVYPWMRKVHV	HOXB4	136	P17483
GQLNPKWTKYVHKVC	PI4K2B	156	Q8TCG2
WYPEVNHFCKKVPII	RHOD	111	O00212
HFWVTILPAKKKYPE	DEFB110	11	Q30KQ9
CHPWVLPVVKKVEQK	GOT1	46	P17174
FVKCPKVSKLEWHPF	CYBB	326	P04839
KCLPVKEIYSWILDH	FOXN2	131	P32314
HQQKWQLPAKCLPKY	LCE7A	6	P0DV60
CLRLHKVLEPYKPQW	CACNA1H	1251	O95180
CHEALLAAWKKNPKY	DHX37	1116	Q8IY37
FYTHQELWCKAPVKP	NNT	36	Q13423
PLYEVMLKCWHPKAE	MET	1311	P08581
PKVKCLTKIWHPNIT	UBE2F	96	Q969M7
LNHKPKGKWYCPKCR	ING1	386	Q9UK53
PEKCYLPKKQIHVWS	CDC40	271	O60508
KPPWTLLHLLQCFKK	SWT1	616	Q5T5J6
KKVIQWCTHHKDDPP	SKP1	56	P63208
TSPDYHPKKGCKWTL	TTLL9	261	Q3SXZ7
HKQKAWKIYPPEFAV	TPTE2	501	Q6XPS3
WYPGKPLKVKYHCQE	RARRES1	256	P49788
WKTDIKKYHRIQCPN	ZNF512	396	Q96ME7