Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	PSEN1 SLC39A2 COX15 GRIK1 SLC46A1 ASIC3 SLC5A5 ANO6 GHITM SLC28A1 TMCO3 SLC24A1 SLC39A7	2.69e-05	664	100	13	GO:0008324
GeneOntologyMolecularFunction	olfactory receptor activity	OR7A5 OR4F4 OR4M1 OR14J1 OR52J3 OR4F5 OR4C3 OR4C46 OR4F17 OR52Z1P	6.06e-05	431	100	10	GO:0004984
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	PSEN1 SLC39A2 COX15 GRIK1 SLC46A1 ASIC3 SLC5A5 GHITM SLC28A1 TMCO3 SLC24A1 SLC39A7	6.99e-05	627	100	12	GO:0022890
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	PSEN1 SLC39A2 COX15 GRIK1 SLC46A1 ASIC3 SLC5A5 ANO6 GHITM SLC28A1 TMCO3 SLC24A1 SLC39A7	1.04e-04	758	100	13	GO:0015318
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	PSEN1 SLC39A2 GRIK1 ASIC3 SLC5A5 GHITM SLC28A1 TMCO3 SLC24A1 SLC39A7	1.14e-04	465	100	10	GO:0046873
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR7A5 FZD3 OR4F4 OR4M1 OR14J1 NMUR1 GRIK1 OR52J3 LHCGR OR4F5 FCGR2C OR4C3 FCGR2B IL1R2 OR4C46 OR4F17 ADGRD2 OR52Z1P	1.21e-04	1353	100	18	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR7A5 FZD3 OR4F4 OR4M1 OR14J1 NMUR1 OR52J3 LHCGR OR4F5 OR4C3 OR4C46 OR4F17 ADGRD2 OR52Z1P	1.28e-04	884	100	14	GO:0004930
GeneOntologyMolecularFunction	carboxylic ester hydrolase activity	PLA2G7 ABHD12B CES1 ABHD10 LIPC CES3	1.39e-04	157	100	6	GO:0052689
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	PSEN1 SLC39A2 COX15 GRIK1 SLC46A1 ASIC3 SLC5A5 ANO6 GHITM SLC28A1 TMCO3 SLC24A1 SLC39A7	1.62e-04	793	100	13	GO:0015075
GeneOntologyMolecularFunction	transporter activity	CIDEB PSEN1 SLC39A2 ABCB6 COX15 GRIK1 SLC46A1 ASIC3 SLC5A5 ANO6 SLC2A6 GHITM SLC28A1 TMCO3 SLC52A2 SLC24A1 SLC39A7	2.13e-04	1289	100	17	GO:0005215
GeneOntologyMolecularFunction	transmembrane transporter activity	PSEN1 SLC39A2 ABCB6 COX15 GRIK1 SLC46A1 ASIC3 SLC5A5 ANO6 SLC2A6 GHITM SLC28A1 TMCO3 SLC52A2 SLC24A1 SLC39A7	2.45e-04	1180	100	16	GO:0022857
GeneOntologyMolecularFunction	carboxylesterase activity	CES1 CES3	3.68e-04	6	100	2	GO:0106435
GeneOntologyMolecularFunction	IgG receptor activity	FCGR2C FCGR2B	5.13e-04	7	100	2	GO:0019770
GeneOntologyMolecularFunction	vitamin transmembrane transporter activity	SLC46A1 SLC2A6 SLC52A2	7.72e-04	36	100	3	GO:0090482
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	COX15 SLC46A1 SLC5A5 GHITM SLC28A1 TMCO3 SLC24A1	7.99e-04	301	100	7	GO:0022853
GeneOntologyMolecularFunction	heme transmembrane transporter activity	ABCB6 SLC46A1	8.74e-04	9	100	2	GO:0015232
GeneOntologyMolecularFunction	metal cation:monoatomic cation antiporter activity	GHITM TMCO3 SLC24A1	1.30e-03	43	100	3	GO:0140828
GeneOntologyMolecularFunction	IgG binding	FCGR2C FCGR2B	1.33e-03	11	100	2	GO:0019864
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	GRIK1 ASIC3 SLC5A5 SLC28A1 SLC24A1	1.70e-03	171	100	5	GO:0015081
GeneOntologyMolecularFunction	calcium:monoatomic cation antiporter activity	GHITM SLC24A1	1.87e-03	13	100	2	GO:0015368
GeneOntologyMolecularFunction	immunoglobulin receptor activity	FCGR2C FCGR2B	2.17e-03	14	100	2	GO:0019763
GeneOntologyMolecularFunction	glutamate binding	GRIK1 GLUL	2.17e-03	14	100	2	GO:0016595
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR7A5 OR4F4 OR4M1 OR14J1 ASIC3 OR52J3 OR4F5 OR4C3 OR4C46 OR4F17 OR52Z1P	2.12e-05	485	99	11	GO:0050907
GeneOntologyBiologicalProcess	iron coordination entity transport	ABCB6 SLC46A1 ASIC3	2.29e-05	12	99	3	GO:1901678
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	PSEN1 SLC39A2 ABCB6 COX15 GRIK1 SLC46A1 ASIC3 SLC5A5 LHCGR CD19 ANO6 GHITM TMCO3 SLC24A1 SLC39A7	3.26e-05	922	99	15	GO:0098662
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	PSEN1 SLC39A2 ABCB6 COX15 GRIK1 SLC46A1 ASIC3 SLC5A5 LHCGR CD19 ANO6 GHITM TMCO3 SLC24A1 SLC39A7	4.17e-05	942	99	15	GO:0098655
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR7A5 OR4F4 OR4M1 OR14J1 ASIC3 OR52J3 OR4F5 OR4C3 OR4C46 OR4F17 OR52Z1P	4.30e-05	524	99	11	GO:0009593
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR7A5 OR4F4 OR4M1 OR14J1 OR52J3 OR4F5 OR4C3 OR4C46 OR4F17 OR52Z1P	4.33e-05	432	99	10	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR7A5 OR4F4 OR4M1 OR14J1 ASIC3 OR52J3 OR4F5 OR4C3 OR4C46 OR4F17 OR52Z1P	6.32e-05	547	99	11	GO:0007606
GeneOntologyBiologicalProcess	sensory perception of smell	OR7A5 OR4F4 OR4M1 OR14J1 OR52J3 OR4F5 OR4C3 OR4C46 OR4F17 OR52Z1P	8.00e-05	465	99	10	GO:0007608
GeneOntologyBiologicalProcess	modified amino acid metabolic process	ABHD12B CHDH NAT8 SLC46A1 SLC5A5 LIPC PEMT	8.74e-05	218	99	7	GO:0006575
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	PSEN1 SLC39A2 ABCB6 COX15 GRIK1 SLC46A1 ASIC3 SLC5A5 LHCGR CD19 ANO6 GHITM TMCO3 SLC24A1 SLC39A7	9.88e-05	1017	99	15	GO:0098660
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR7A5 OR4F4 OR4M1 OR14J1 ASIC3 OR52J3 OR4F5 OR4C3 OR4C46 OR4F17 OR52Z1P	1.10e-04	582	99	11	GO:0050906
GeneOntologyBiologicalProcess	negative regulation of dendritic cell antigen processing and presentation	THBS1 FCGR2B	1.36e-04	4	99	2	GO:0002605
GeneOntologyBiologicalProcess	regulation of plasma lipoprotein particle levels	PLA2G7 CIDEB CES1 LIPC CES3	1.39e-04	103	99	5	GO:0097006
GeneOntologyBiologicalProcess	plasma lipoprotein particle organization	PLA2G7 CIDEB CES1 LIPC	1.41e-04	55	99	4	GO:0071827
GeneOntologyBiologicalProcess	protein-lipid complex organization	PLA2G7 CIDEB CES1 LIPC	1.86e-04	59	99	4	GO:0071825
GeneOntologyBiologicalProcess	transition metal ion transport	SLC39A2 ABCB6 SLC46A1 ASIC3 SLC39A7	2.14e-04	113	99	5	GO:0000041
GeneOntologyBiologicalProcess	Fc receptor signaling pathway	MAP3K1 FCGR2C FCGR2B MAP3K7	2.25e-04	62	99	4	GO:0038093
GeneOntologyBiologicalProcess	porphyrin-containing compound metabolic process	ABCB6 COX15 SLC46A1 UGT1A1	2.39e-04	63	99	4	GO:0006778
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	PSEN1 SLC39A2 ABCB6 COX15 GRIK1 SLC46A1 ASIC3 SLC5A5 LHCGR CD19 ANO6 GHITM TMCO3 SLC24A1 SLC39A7	2.69e-04	1115	99	15	GO:0034220
GeneOntologyBiologicalProcess	metal ion transport	PSEN1 SLC39A2 ABCB6 GRIK1 SLC46A1 ASIC3 SLC5A5 LHCGR CD19 ANO6 GHITM TMCO3 SLC24A1 SLC39A7	2.94e-04	1000	99	14	GO:0030001
GeneOntologyBiologicalProcess	intracellular sphingolipid homeostasis	ATG7 ORMDL1	3.38e-04	6	99	2	GO:0090156
GeneOntologyBiologicalProcess	glycerolipid catabolic process	PLA2G7 ABHD12B CES1 LIPC	3.59e-04	70	99	4	GO:0046503
GeneOntologyBiologicalProcess	monoatomic cation transport	PSEN1 SLC39A2 ABCB6 COX15 GRIK1 SLC46A1 ASIC3 SLC5A5 LHCGR CD19 ANO6 GHITM TMCO3 SLC24A1 SLC39A7	3.99e-04	1157	99	15	GO:0006812
GeneOntologyBiologicalProcess	tetrapyrrole metabolic process	ABCB6 COX15 SLC46A1 UGT1A1	4.22e-04	73	99	4	GO:0033013
GeneOntologyBiologicalProcess	negative regulation of sphingolipid biosynthetic process	ATG7 ORMDL1	4.71e-04	7	99	2	GO:0090155
Domain	-	PLA2G7 ABHD12B CES1 ABHD10 LIPC CES3	4.31e-05	119	100	6	3.40.50.1820
Domain	AB_hydrolase	PLA2G7 ABHD12B CES1 ABHD10 LIPC CES3	4.31e-05	119	100	6	IPR029058
Domain	Olfact_rcpt	OR7A5 OR4F4 OR4M1 OR14J1 OR52J3 OR4F5 OR4C3 OR4C46 OR4F17	2.60e-04	393	100	9	IPR000725
Domain	Carboxylesterase_B_AS	CES1 CES3	7.78e-04	8	100	2	IPR019826
Domain	CARBOXYLESTERASE_B_1	CES1 CES3	7.78e-04	8	100	2	PS00122
Domain	GPCR_Rhodpsn_7TM	OR7A5 OR4F4 OR4M1 OR14J1 NMUR1 OR52J3 LHCGR OR4F5 OR4C3 OR4C46 OR4F17	9.12e-04	670	100	11	IPR017452
Domain	7tm_1	OR7A5 OR4F4 OR4M1 OR14J1 NMUR1 OR52J3 LHCGR OR4F5 OR4C3 OR4C46 OR4F17	9.92e-04	677	100	11	PF00001
Domain	WD40_repeat_dom	NWD1 WDR3 WDR97 ARHGEF10 PRPF4 WDR87 TAF5	1.09e-03	297	100	7	IPR017986
Domain	G_PROTEIN_RECEP_F1_1	OR7A5 OR4F4 OR4M1 OR14J1 NMUR1 OR52J3 LHCGR OR4F5 OR4C3 OR4C46 OR4F17	1.09e-03	685	100	11	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR7A5 OR4F4 OR4M1 OR14J1 NMUR1 OR52J3 LHCGR OR4F5 OR4C3 OR4C46 OR4F17	1.17e-03	691	100	11	PS50262
Domain	GPCR_Rhodpsn	OR7A5 OR4F4 OR4M1 OR14J1 NMUR1 OR52J3 LHCGR OR4F5 OR4C3 OR4C46 OR4F17	1.18e-03	692	100	11	IPR000276
Domain	WD40_repeat_CS	NWD1 WDR3 WDR97 PRPF4 TAF5	1.89e-03	164	100	5	IPR019775
Domain	-	NWD1 WDR3 WDR97 ARHGEF10 PRPF4 WDR87 TAF5	2.09e-03	333	100	7	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	NWD1 WDR3 WDR97 ARHGEF10 PRPF4 WDR87 TAF5	2.16e-03	335	100	7	IPR015943
Domain	CARBOXYLESTERASE_B_2	CES1 CES3	2.48e-03	14	100	2	PS00941
Domain	Zip	SLC39A2 SLC39A7	2.48e-03	14	100	2	PF02535
Domain	COesterase	CES1 CES3	2.48e-03	14	100	2	PF00135
Domain	CarbesteraseB	CES1 CES3	2.48e-03	14	100	2	IPR002018
Domain	ZIP	SLC39A2 SLC39A7	2.48e-03	14	100	2	IPR003689
Domain	WD40	NWD1 WDR3 WDR97 PRPF4 WDR87 TAF5	2.70e-03	259	100	6	PF00400
Domain	WD40	NWD1 WDR3 WDR97 PRPF4 WDR87 TAF5	3.19e-03	268	100	6	SM00320
Domain	WD40_repeat	NWD1 WDR3 WDR97 PRPF4 WDR87 TAF5	3.44e-03	272	100	6	IPR001680
Domain	WD_REPEATS_1	NWD1 WDR3 WDR97 PRPF4 WDR87 TAF5	3.82e-03	278	100	6	PS00678
Domain	WD_REPEATS_2	NWD1 WDR3 WDR97 PRPF4 WDR87 TAF5	3.89e-03	279	100	6	PS50082
Domain	WD_REPEATS_REGION	NWD1 WDR3 WDR97 PRPF4 WDR87 TAF5	3.89e-03	279	100	6	PS50294
Domain	Apc4_WD40_dom	NWD1 WDR3	5.06e-03	20	100	2	IPR024977
Domain	ANAPC4_WD40	NWD1 WDR3	5.06e-03	20	100	2	PF12894
Pathway	WP_NRF2_PATHWAY	SLC39A2 CES1 SLC5A5 UGT1A1 SLC2A6 CES3 SLC39A7	8.10e-06	141	73	7	M39454
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR7A5 OR4F4 OR4M1 OR14J1 OR52J3 OR4F5 OR4C3 OR4C46 OR4F17 OR52Z1P	5.41e-05	417	73	10	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR7A5 OR4F4 OR4M1 OR14J1 OR52J3 OR4F5 OR4C3 OR4C46 OR4F17	1.72e-04	389	73	9	M14091
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC39A2 ABCB6 SLC46A1 ASIC3 SLC5A5 LIPC ANO6 SLC2A6 SLC28A1 CES3 SLC24A1 SLC39A7	1.79e-04	681	73	12	MM14985
Pathway	WP_NUCLEAR_RECEPTORS_METAPATHWAY	ACAA1 SLC39A2 CES1 SLC5A5 UGT1A1 SLC2A6 CES3 SLC39A7	2.12e-04	314	73	8	M39428
Pathway	PID_BCR_5PATHWAY	MAP3K1 CD19 FCGR2B MAP3K7	3.13e-04	63	73	4	M10
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC39A2 ABCB6 SLC46A1 ASIC3 SLC5A5 LIPC ANO6 SLC2A6 SLC28A1 CES3 SLC24A1 SLC39A7	3.66e-04	736	73	12	M27287
Pathway	REACTOME_SENSORY_PERCEPTION	OR7A5 OR4F4 OR4M1 OR14J1 OR52J3 OR4F5 OR4C3 OR4C46 OR4F17 OR52Z1P SLC24A1	4.02e-04	636	73	11	M41834
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR7A5 OR4F4 OR4M1 OR14J1 OR52J3 OR4C3 OR4C46 OR52Z1P	8.16e-06	340	103	8	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR7A5 OR4F4 OR4M1 OR14J1 OR52J3 OR4C3 OR4C46 OR52Z1P	8.16e-06	340	103	8	11802173
Pubmed	Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.	FCGR2C FCGR2B	8.69e-06	2	103	2	2531080
Pubmed	Phosphatidylethanolamine N-methyltransferase and choline dehydrogenase gene polymorphisms are associated with human sperm concentration.	CHDH PEMT	8.69e-06	2	103	2	22387881
Pubmed	Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location.	OR4F4 OR4F17	8.69e-06	2	103	2	11689484
Pubmed	Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non-homologous chromosomes.	OR4F4 OR4F17	8.69e-06	2	103	2	11689483
Pubmed	Identification of a novel intracellular cholesteryl ester hydrolase (carboxylesterase 3) in human macrophages: compensatory increase in its expression after carboxylesterase 1 silencing.	CES1 CES3	8.69e-06	2	103	2	22700792
Pubmed	Suppression of innate and adaptive B cell activation pathways by antibody coengagement of FcγRIIb and CD19.	CD19 FCGR2B	8.69e-06	2	103	2	24828435
Pubmed	CD19 and CD32b differentially regulate human B cell responsiveness.	CD19 FCGR2B	8.69e-06	2	103	2	24442430
Pubmed	Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene.	FCGR2C FCGR2B	8.69e-06	2	103	2	9516136
Pubmed	A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation.	CD19 MAP3K7	8.69e-06	2	103	2	19196865
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR7A5 OR4F4 OR4M1 OR14J1 OR52J3 OR4C3 OR4C46 OR52Z1P	8.69e-06	343	103	8	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR7A5 OR4F4 OR4M1 OR14J1 OR52J3 OR4C3 OR4C46 OR52Z1P	9.26e-06	346	103	8	14611657
Pubmed	Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.	PIGN ATG7 ABCB6 STT3B NT5DC2 GHITM MAP3K7	2.23e-05	283	103	7	21903422
Pubmed	Common genetic polymorphisms affect the human requirement for the nutrient choline.	CHDH PEMT	2.60e-05	3	103	2	16816108
Pubmed	Human carboxylesterases: an update on CES1, CES2 and CES3.	CES1 CES3	2.60e-05	3	103	2	19508181
Pubmed	Transactivation of the epidermal growth factor receptor is involved in the lutropin receptor-mediated down-regulation of ovarian aromatase expression in vivo.	CYP19A1 LHCGR	2.60e-05	3	103	2	20093417
Pubmed	Polymorphisms of ESR1, UGT1A1, HCN1, MAP3K1 and CYP2B6 are associated with the prognosis of hormone receptor-positive early breast cancer.	CYP19A1 MAP3K1	2.60e-05	3	103	2	28178648
Pubmed	Repeat polymorphisms in estrogen metabolism genes and prostate cancer risk: results from the Prostate Cancer Prevention Trial.	CYP19A1 UGT1A1	2.60e-05	3	103	2	21771722
Pubmed	Choline metabolic pathway gene polymorphisms and risk for Down syndrome: An association study in a population with folate-homocysteine metabolic impairment.	CHDH PEMT	2.60e-05	3	103	2	27677362
Pubmed	Essential role for autophagy in the maintenance of immunological memory against influenza infection.	ATG7 CD19	2.60e-05	3	103	2	24747745
Pubmed	Immunotherapy targeting inhibitory Fcγ receptor IIB (CD32b) in the mouse is limited by monoclonal antibody consumption and receptor internalization.	CD19 FCGR2B	2.60e-05	3	103	2	24026082
Pubmed	Nonallelic homologous recombination of the FCGR2/3 locus results in copy number variation and novel chimeric FCGR2 genes with aberrant functional expression.	FCGR2C FCGR2B	2.60e-05	3	103	2	26133275
Pubmed	Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex.	PSEN1 CRB2	2.60e-05	3	103	2	20299451
Pubmed	Ces3/TGH Deficiency Attenuates Steatohepatitis.	CES1 PEMT	2.60e-05	3	103	2	27181051
Pubmed	Choline metabolism and risk of breast cancer in a population-based study.	CHDH PEMT	2.60e-05	3	103	2	18230680
Pubmed	Decreased Expression of EZH2 in Granulosa Cells Contributes to Endometriosis-Associated Infertility by Targeting IL-1R2.	CYP19A1 IL1R2	2.60e-05	3	103	2	36524678
Pubmed	Essential function for the kinase TAK1 in innate and adaptive immune responses.	CD19 MAP3K7	2.60e-05	3	103	2	16186825
Pubmed	Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus.	FCGR2C FCGR2B	2.60e-05	3	103	2	23261299
Pubmed	Through an ITIM-independent mechanism the FcγRIIB blocks B cell activation by disrupting the colocalized microclustering of the B cell receptor and CD19.	CD19 FCGR2B	2.60e-05	3	103	2	24790152
Pubmed	Gene Expression in Granulosa Cells From Small Antral Follicles From Women With or Without Polycystic Ovaries.	CYP19A1 LHCGR	2.60e-05	3	103	2	31276164
Pubmed	Functional Fcgamma receptor polymorphisms are associated with human allergy.	FCGR2C FCGR2B	2.60e-05	3	103	2	24586589
Pubmed	Expression of mRNA for the LH and FSH receptors in mouse oocytes and preimplantation embryos.	CYP19A1 LHCGR	2.60e-05	3	103	2	11226072
Pubmed	SHEP1 partners with CasL to promote marginal zone B-cell maturation.	SH2D3C CD19	2.60e-05	3	103	2	20956287
Pubmed	Defective signal transduction in B lymphocytes lacking presenilin proteins.	PSEN1 CD19	2.60e-05	3	103	2	18195359
Pubmed	A threshold concentration of FSH is needed during IVM of ex vivo collected human oocytes.	CYP19A1 LHCGR	2.60e-05	3	103	2	34050448
Pubmed	Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.	ACAA1 ABHD10 CHDH L2HGDH COX15 MRPL22 NT5DC2 GHITM	3.29e-05	413	103	8	27499296
Pubmed	FcγRIIb on B Cells and Myeloid Cells Modulates B Cell Activation and Autoantibody Responses via Different but Synergistic Pathways in Lupus-Prone Yaa Mice.	CD19 FCGR2B	5.19e-05	4	103	2	30373853
Pubmed	Structure and characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes.	CES1 CES3	5.19e-05	4	103	2	18794728
Pubmed	Increased incidence of anti-GBM disease in Fcgamma receptor 2b deficient mice, but not mice with conditional deletion of Fcgr2b on either B cells or myeloid cells alone.	CD19 FCGR2B	5.19e-05	4	103	2	22244885
Pubmed	TOM1 Regulates Neuronal Accumulation of Amyloid-β Oligomers by FcγRIIb2 Variant in Alzheimer's Disease.	PSEN1 FCGR2B	5.19e-05	4	103	2	30185465
Pubmed	FcγRIIb on myeloid cells and intrinsic renal cells rather than B cells protects from nephrotoxic nephritis.	CD19 FCGR2B	5.19e-05	4	103	2	23203925
Pubmed	Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes.	OR4F4 OR4F17	5.19e-05	4	103	2	9384599
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	ATG7 TTLL5 ASIC3 MAP3K1 SLC24A1 CRB2	7.05e-05	233	103	6	32290105
Pubmed	Regulatory dendritic cells program B cells to differentiate into CD19hiFcγIIbhi regulatory B cells through IFN-β and CD40L.	CD19 FCGR2B	8.64e-05	5	103	2	22692512
Pubmed	TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.	MAP3K1 MAP3K7	8.64e-05	5	103	2	18984593
Pubmed	Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B.	FCGR2C FCGR2B	8.64e-05	5	103	2	19309690
Pubmed	Mammalian carboxylesterase 3: comparative genomics and proteomics.	CES1 CES3	8.64e-05	5	103	2	20422440
Pubmed	SNPs of Fc-gamma receptor genes and chronic periodontitis.	FCGR2C FCGR2B	8.64e-05	5	103	2	20439936
Pubmed	Copy number, linkage disequilibrium and disease association in the FCGR locus.	FCGR2C FCGR2B	8.64e-05	5	103	2	20508037
Pubmed	An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway.	MAP3K1 MAP3K7	1.29e-04	6	103	2	17110930
Pubmed	Association of six CpG-SNPs in the inflammation-related genes with coronary heart disease.	PLA2G7 IL1R2	1.29e-04	6	103	2	27461004
Pubmed	Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins.	CES1 CES3	1.29e-04	6	103	2	20931200
Pubmed	FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model.	PSEN1 FCGR2B	1.81e-04	7	103	2	27834631
Pubmed	Influence of polygenetic polymorphisms on the susceptibility to non-alcoholic fatty liver disease of Chinese people.	LIPC PEMT	1.81e-04	7	103	2	20492333
Pubmed	Ankfy1 is dispensable for neural stem/precursor cell development.	ANKFY1 GLUL	1.81e-04	7	103	2	28123425
Pubmed	Polymorphisms located in the region containing BHMT and BHMT2 genes as maternal protective factors for orofacial clefts.	CHDH PEMT	1.81e-04	7	103	2	20662904
Pubmed	Maternal high-fat diet-induced microbiota changes are associated with alterations in embryonic brain metabolites and adolescent behaviour.	GRIK1 GLUL	2.40e-04	8	103	2	39032541
Pubmed	A Unique Role of Carboxylesterase 3 (Ces3) in β-Adrenergic Signaling-Stimulated Thermogenesis.	CES1 CES3	2.40e-04	8	103	2	30862682
Pubmed	MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta.	MAP3K1 MAP3K7	2.40e-04	8	103	2	9689078
Pubmed	Polymorphisms in steroid hormone pathway genes and mammographic density.	CYP19A1 UGT1A1	2.40e-04	8	103	2	12602902
Pubmed	TRIM5 is an innate immune sensor for the retrovirus capsid lattice.	MAP3K1 MAP3K7	3.08e-04	9	103	2	21512573
Pubmed	Genetic variation in sex hormone genes influences heel ultrasound parameters in middle-aged and elderly men: results from the European Male Aging Study (EMAS).	CYP19A1 LHCGR	3.08e-04	9	103	2	18767927
Pubmed	A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity.	CD19 LY75	3.08e-04	9	103	2	20709950
Pubmed	Effect of polymorphisms in selected genes involved in pituitary-testicular function on reproductive hormones and phenotype in aging men.	CYP19A1 LHCGR	3.08e-04	9	103	2	20173016
Pubmed	A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase.	MAP3K1 MAP3K7	3.08e-04	9	103	2	12624112
Pubmed	Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.	PSEN1 STT3B	3.85e-04	10	103	2	20541250
Pubmed	Irinotecan pathway genotype analysis to predict pharmacokinetics.	CES1 UGT1A1	3.85e-04	10	103	2	12960109
Pubmed	Discovery and refinement of loci associated with lipid levels.	ATG7 MAP3K1 UGT1A1 LIPC OR4C46	4.24e-04	211	103	5	24097068
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	ACAA1 ABHD10 CHDH L2HGDH ABCB6 COX15 GUF1 MRPL22 GHITM TMEM143	4.32e-04	926	103	10	20877624
Pubmed	Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation.	ATG7 CD19	4.69e-04	11	103	2	26764599
Pubmed	BTG1 mutation yields supercompetitive B cells primed for malignant transformation.	CD19 LY75	4.69e-04	11	103	2	36656933
Pubmed	Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men.	CYP19A1 IL1R2	5.62e-04	12	103	2	24049095
Pubmed	Associations of folate and choline metabolism gene polymorphisms with orofacial clefts.	CHDH PEMT	5.62e-04	12	103	2	19737740
Pubmed	A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot.	CYP19A1 LIPC	6.63e-04	13	103	2	17103052
Pubmed	Establishment of fetomaternal tolerance through glycan-mediated B cell suppression.	CD19 FCGR2B	6.63e-04	13	103	2	35236989
Pubmed	The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A.	AKTIP AP1M1	6.63e-04	13	103	2	32073997
Pubmed	FISH mapping of three ammonia metabolism genes (Glul, Cps1, Glud1) in rat, and the chromosomal localization of GLUL in human and Cps1 in mouse.	UGT1A1 GLUL	6.63e-04	13	103	2	9107685
Pubmed	Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients.	THBS1 LIPC	6.63e-04	13	103	2	14557872
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	DNHD1 CLDN14 SH2D3C SCG3 GHITM CES3 C1QTNF6 TMCO3 TMEM143 TMEM50B	6.95e-04	985	103	10	12975309
Pubmed	Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex.	MAP3K1 MAP3K7	8.89e-04	15	103	2	18635759
Pubmed	MAP3Ks as central regulators of cell fate during development.	MAP3K1 MAP3K7	8.89e-04	15	103	2	18855897
Pubmed	Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.	GRIK1 IL1R2 NEURL1	9.64e-04	65	103	3	23453885
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	ACAA1 ABHD10 CHDH L2HGDH ABCB6 COX15 GUF1 MRPL22 GHITM TMEM143	1.10e-03	1047	103	10	18614015
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	TMEM8B TMEM187 GRIK1 MAP3K1 SLC2A6 GHITM TMCO3 SLC52A2	1.12e-03	697	103	8	28298427
Pubmed	ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family.	GRIK1 FCGR2B	1.15e-03	17	103	2	10464288
Pubmed	Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk.	CYP19A1 UGT1A1	1.15e-03	17	103	2	20381444
Pubmed	Genome-wide association of serum bilirubin levels in Korean population.	UGT1A1 ORMDL1	1.15e-03	17	103	2	20639394
Pubmed	The human olfactory receptor gene family.	OR7A5 OR4F4 OR4M1 OR14J1 OR52J3 OR4C3 OR52Z1P	1.16e-03	541	103	7	14983052
Pubmed	Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities.	GRIK1 SIPA1L2	1.29e-03	18	103	2	20602751
Pubmed	Interleukin-1-mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo.	IL1R2 MAP3K7	1.29e-03	18	103	2	18805969
Pubmed	The frantic play of the concealed HIV envelope cytoplasmic tail.	AP1M1 MAP3K7	1.29e-03	18	103	2	23705972
Pubmed	Interactome Analysis of the Nucleocapsid Protein of SARS-CoV-2 Virus.	STT3B WDR3 MRPL22 PRPF4	1.31e-03	159	103	4	34578187
Pubmed	A genome-wide assessment of variability in human serum metabolism.	UGT1A1 LIPC	1.44e-03	19	103	2	23281178
Pubmed	Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosis.	GLUL CRB2	1.44e-03	19	103	2	22398208
Pubmed	Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression.	PSEN1 FZD3	1.44e-03	19	103	2	20219685
Pubmed	Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage.	CYP19A1 LHCGR	1.59e-03	20	103	2	20716560
Pubmed	Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.	CYP19A1 UGT1A1 IL1R2	1.69e-03	79	103	3	20140262
Pubmed	A series of recombinant inbred strains between the BALB/cHeA and STS/A mouse strains.	CES1 FCGR2B	1.76e-03	21	103	2	4042679
Pubmed	Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.	ATG7 STT3B ORMDL1 HEG1 SLC2A6 SCG3	1.80e-03	430	103	6	16303743
Interaction	TMEM14B interactions	CIDEB SLC39A2 SH2D3C NAT8 TMEM187 ORMDL1 SLC2A6 SLC39A7 TMEM50B	6.82e-06	279	95	9	int:TMEM14B
Cytoband	3q13.2	PLCXD2 ABHD10 TMPRSS7	4.71e-05	31	103	3	3q13.2
GeneFamily	Olfactory receptors, family 4	OR4F4 OR4M1 OR4F5 OR4C3 OR4C46 OR4F17	1.25e-05	129	72	6	151
GeneFamily	Carboxylesterases	CES1 CES3	1.55e-04	5	72	2	461
GeneFamily	Solute carriers	SLC39A2 SLC46A1 SLC5A5 SLC2A6 SLC28A1 SLC52A2 SLC24A1 SLC39A7	1.71e-04	395	72	8	752
GeneFamily	WD repeat domain containing	NWD1 WDR3 WDR97 PRPF4 WDR87 TAF5	6.14e-04	262	72	6	362
GeneFamily	Abhydrolase domain containing	ABHD12B ABHD10	3.43e-03	22	72	2	4
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	MAP3K1 MAP3K7	4.08e-03	24	72	2	654
Coexpression	THAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_NONRESPONDER_7DY_UP	PIGN ABHD10 COX15 MAP3K1 PAPOLA MAP3K7	8.91e-06	127	99	6	M40905
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ABHD12B CYP19A1 THBS1 CD19 FCGR2B IL1R2 NEURL1	1.48e-07	171	103	7	2b8dbc6fcd829d06f43b875db2bf81f8374428fa
ToppCell	facs-Trachea-18m-Hematologic-myeloid-granulocyte-granulocyte_l8\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ABHD12B SH2D3C GRIK1 THBS1 IL1R2 SLC2A6	1.77e-06	157	103	6	5098675f64342c41c5ca3551b24962d10c83e64d
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHDH NAT8 ABCB6 UGT1A1 LIPC CES3	4.17e-06	182	103	6	770ce9f3f4538d0181a0181543841bc964c68274
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHDH NAT8 ABCB6 UGT1A1 LIPC CES3	4.17e-06	182	103	6	77ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHDH NAT8 ABCB6 UGT1A1 LIPC CES3	4.17e-06	182	103	6	4921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CYP19A1 FCGR2C THBS1 FCGR2B IL1R2 GLUL	4.30e-06	183	103	6	c289a257918aa660db8657810b3c4881382d56f3
ToppCell	mild_COVID-19_(asymptomatic)-Non-classical_Monocyte\|World / disease group, cell group and cell class (v2)	SH2D3C SFMBT2 HEG1 SLC2A6 ANKDD1A NEURL1	6.19e-06	195	103	6	eb809331557f8c40de45b1208cbc49b621930a4b
ToppCell	10x5'v1-week_12-13-Myeloid_macrophage-stroma-stromal_macrophage\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	PLA2G7 FCGR2C IL1R2 GLUL SLC28A1 SIPA1L2	6.56e-06	197	103	6	075044c17f1c52008cd3c292c15cbf485b50411e
ToppCell	primary_visual_cortex-Non-neuronal-astrocyte\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PLA2G7 CIDEB NWD1 NAT8 GLUL	2.85e-05	153	103	5	95b28c5bd10ffb74c0993ebd565038b9818e4bd2
ToppCell	primary_visual_cortex-Non-neuronal-astrocyte-Astro\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PLA2G7 CIDEB NWD1 NAT8 GLUL	2.85e-05	153	103	5	b09f8def40a1ea56722f3398f61a036667b61cd9
ToppCell	primary_visual_cortex-Non-neuronal-astrocyte-Astro-Astro_Aqp4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PLA2G7 CIDEB NWD1 NAT8 GLUL	2.85e-05	153	103	5	3ab9d55b3db51715c1d61eca142384195ce4b54f
ToppCell	frontal_cortex-Non-neuronal-astrocyte-Astro\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PLA2G7 CIDEB NWD1 NAT8 GLUL	3.23e-05	157	103	5	0551442ae14685d8fe5729e3960c6324b1e05e4d
ToppCell	frontal_cortex-Non-neuronal-astrocyte\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PLA2G7 CIDEB NWD1 NAT8 GLUL	3.23e-05	157	103	5	803af734d7f775d294391e2b84e472a732e18cef
ToppCell	frontal_cortex-Non-neuronal-astrocyte-Astro-Astro_Aqp4\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PLA2G7 CIDEB NWD1 NAT8 GLUL	3.23e-05	157	103	5	9aa5304a9704da6dd4eda7d6940494b00e38b2e8
ToppCell	facs-Heart-RV-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFMBT2 THBS1 IL1R2 SLC2A6 SLC24A1	3.33e-05	158	103	5	2a222301474c4dfd9a776e197c10f4c1cacceb62
ToppCell	facs-Heart-RV-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFMBT2 THBS1 IL1R2 SLC2A6 SLC24A1	3.33e-05	158	103	5	ff9878fd768f22bf2ee4805bac2ba01cb3cb804a
ToppCell	LPS-antiTNF-Endothelial-Mes-Like-Alv_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANKFY1 TMEM8B LIPC OTUD7A TMEM50B	4.21e-05	166	103	5	94a00edf66d54bc5f7343daea700ca26cf38fd90
ToppCell	facs-Aorta-Heart-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CIDEB ACAA1 NAT8 LHCGR SLC28A1	4.58e-05	169	103	5	daed9083ee05c220365200328c2c50047fe21efd
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|lymph-node_spleen / Manually curated celltypes from each tissue	NWD1 CES1 CYP19A1 THBS1 NT5DC2	5.12e-05	173	103	5	783b8fa08b9d8f597f251793eae164151662f1f9
ToppCell	facs-Diaphragm-Limb_Muscle-18m-Lymphocytic-B_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA7 LIPC CD19 FCGR2B IL1R2	5.12e-05	173	103	5	a693772987f1baee533dd0bd285a3c7b5619a73b
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-SMG_basal_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	NWD1 WDR97 IL1R2 CES3 LY75	5.41e-05	175	103	5	4462000b22af227555413ba202a872868eecde6c
ToppCell	facs-Liver-Hepatocytes-24m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHDH NAT8 ABCB6 UGT1A1 CES3	6.68e-05	183	103	5	d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	THBS1 FCGR2B SCG3 GLUL SIPA1L2	7.22e-05	186	103	5	f73cb91e74a806858650ae97f543fc779ba4cff8
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	THBS1 FCGR2B SCG3 GLUL SIPA1L2	7.22e-05	186	103	5	8694ca16c9780729f4fba67ba20e35745f1eb4e9
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLA2G7 NWD1 NAT8 LHCGR SCG3	7.22e-05	186	103	5	ac7a84b11b4550c4ac01eab370dc8ab88e4fb72b
ToppCell	15-Airway-Epithelial-Neuroendocrine\|Airway / Age, Tissue, Lineage and Cell class	PLCXD2 GRIK1 SCG3 NEURL1 TMEM178B	7.40e-05	187	103	5	a7d2f30fe0f19e63d44603ece9890acd11b45e52
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Alv_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SH2D3C MYCBPAP HEG1 ARHGEF10 SIPA1L2	7.59e-05	188	103	5	73f6ec915934154f435a376cb274b058ff7c5f35
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FCGR2C THBS1 FCGR2B IL1R2 GLUL	7.59e-05	188	103	5	5f6ad5d693145d846ca561c2fa55465a88e40b90
ToppCell	PBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PLA2G7 CIDEB THBS1 MMS19 SLX1A	7.78e-05	189	103	5	a2f4f1dd5452f7efb7427919a0b90875cf2e1dc7
ToppCell	PBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PLA2G7 CIDEB THBS1 MMS19 SLX1A	7.78e-05	189	103	5	54a45b0cb7dea01caf1cf0a2664c40e5779a0b61
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_7\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ACAA1 CES1 TMEM8B FCGR2B IL1R2	8.18e-05	191	103	5	2699e9bb872f2b561bb976dfdc2746e359bc9daf
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_7\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ACAA1 CES1 TMEM8B FCGR2B IL1R2	8.18e-05	191	103	5	4b94c8b0183ae07d173646b7e7e1d9db04ec9637
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SH2D3C MYCBPAP HEG1 ARHGEF10 SIPA1L2	8.59e-05	193	103	5	a3636c35ed25aabe2f1aba016c9fe125327bbfaf
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CES1 THBS1 FCGR2B IL1R2 GLUL	8.80e-05	194	103	5	12e42433a7b7c17c46049ef450223daf2976a59a
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-D\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FCGR2C THBS1 FCGR2B IL1R2 SLX1A	9.01e-05	195	103	5	10f303cbe92777404e7cc93a4991250ce07e65e1
ToppCell	Control-Non-classical_Monocyte-\|Control / Disease condition and Cell class	SH2D3C SFMBT2 HEG1 SLC2A6 NEURL1	9.23e-05	196	103	5	b17ab094cdc7050c2997e24ed474779b5d6f6146
ToppCell	Control-Non-classical_Monocyte\|Control / Disease condition and Cell class	SH2D3C SFMBT2 HEG1 SLC2A6 NEURL1	9.23e-05	196	103	5	404064ccfe2cb73df7a7f88aa65d86b97dcef9d4
ToppCell	COVID-19-kidney-Macrophages\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PLA2G7 ATG7 FCGR2B IL1R2 GLUL	9.46e-05	197	103	5	3912301018d0863144dcfac8d1fa8adc081748d7
ToppCell	mild_COVID-19-Non-classical_Monocyte\|World / disease group, cell group and cell class (v2)	SH2D3C SFMBT2 SLC2A6 ANKDD1A NEURL1	9.46e-05	197	103	5	368644260f70895052a1d71171a9d882315354dd
ToppCell	nucseq-Immune-Immune_Myeloid-IM\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PLA2G7 ATG7 SFMBT2 FCGR2B GLUL	9.46e-05	197	103	5	6f41c8f815851968849428ec92c16745bd01a3fb
ToppCell	nucseq-Immune-Immune_Myeloid-IM-IM\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PLA2G7 ATG7 SFMBT2 FCGR2B GLUL	9.46e-05	197	103	5	304044ace926943b8eb588f686ecbe5d1689a809
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_hypoxia\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FCGR2C THBS1 FCGR2B IL1R2 GLUL	9.69e-05	198	103	5	dc59442e6a5127d3071a036c206732a21e456a17
ToppCell	COVID-19-kidney-PCT-S3-1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ACAA1 CHDH NAT8 GHITM SLC28A1	9.69e-05	198	103	5	36a60397f49f5381ae377155b73e1891448846b7
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alv_MT\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PLA2G7 THBS1 FCGR2B PRPF4 NEURL1	9.92e-05	199	103	5	4e0b73d88b1345ec63a9e5629762341e75beb47f
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PLA2G7 FCGR2C THBS1 FCGR2B GLUL	9.92e-05	199	103	5	667b8b47a5b388506e3177b46747267fad8024f6
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CIDEB THBS1 CD19 WDR97 IL1R2	1.02e-04	200	103	5	88d713dfc792e7609bf7ecfb28f87cb748088570
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CES1 FCGR2C THBS1 IL1R2 GLUL	1.02e-04	200	103	5	2cca77b2c9d829daa674a844e068f2b083e90d6e
ToppCell	Influenza-Influenza_Severe-Myeloid-CD16+_Monocyte\|Influenza_Severe / Disease, condition lineage and cell class	SLC46A1 SFMBT2 SLC2A6 ANKDD1A NEURL1	1.02e-04	200	103	5	1efdcfcd86e99fbe03db19a2a5ab10808eec282d
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SH2D3C MYCBPAP HEG1 ARHGEF10 SIPA1L2	1.02e-04	200	103	5	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FCGR2C THBS1 FCGR2B IL1R2 GLUL	1.02e-04	200	103	5	3c9e0dc62d14cc00023f7f18053c1a13085d3413
ToppCell	droplet-Lung-30m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_l14\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC46A1 HEG1 PEMT NEURL1	1.08e-04	106	103	4	ede8407ad253080d1fa2a6e2aacf549ce220309a
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_monocytic-non-classical_monocyte\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ABHD12B SLC46A1 NEURL1 CRB2	1.16e-04	108	103	4	695ed3f8cf637d767a6d79b0309d5ee82dfd063f
ToppCell	Globus_pallidus-Macroglia-ASTROCYTE-Gja1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	CIDEB NWD1 NAT8 LHCGR	1.29e-04	111	103	4	7d7aad8e9811c67fb9abfb4ebc75def01a517adf
ToppCell	Globus_pallidus-Macroglia-ASTROCYTE\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	CIDEB NWD1 NAT8 LHCGR	1.29e-04	111	103	4	cb45322fbeafec2f1ab7a3727da69abb1047567d
ToppCell	Hippocampus-Macroglia-ASTROCYTE-Gja1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PLA2G7 CIDEB NWD1 NAT8	1.68e-04	119	103	4	79342c491a214c870ff6215da613db4a28c9d587
ToppCell	Hippocampus-Macroglia-ASTROCYTE\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PLA2G7 CIDEB NWD1 NAT8	1.68e-04	119	103	4	36857095d4e4cc6428d13bf7de04daec1f4cde1e
ToppCell	Striatum-Macroglia-ASTROCYTE-Gja1\|Striatum / BrainAtlas - Mouse McCarroll V32	CIDEB NWD1 NAT8 LHCGR	1.68e-04	119	103	4	d47880ef1cff036192c43646a04fa8598dd7e1f4
ToppCell	Striatum-Macroglia-ASTROCYTE\|Striatum / BrainAtlas - Mouse McCarroll V32	CIDEB NWD1 NAT8 LHCGR	1.68e-04	119	103	4	0583387cc4497cf991fa42a81f2f66d9c6b774eb
Disease	Alcohol withdrawal syndrome	CYP19A1 GLUL	2.84e-04	8	95	2	C0236663
Disease	systemic lupus erythematosus (implicated_via_orthology)	ATG7 FCGR2C FCGR2B	3.63e-04	43	95	3	DOID:9074 (implicated_via_orthology)
Disease	malaria (implicated_via_orthology)	FCGR2C FCGR2B	3.64e-04	9	95	2	DOID:12365 (implicated_via_orthology)
Disease	plexin-B2 measurement	FCGR2C FCGR2B	3.64e-04	9	95	2	EFO_0021867
Disease	Ankylosing spondylitis	IL1R2 ANO6	5.54e-04	11	95	2	C0038013
Disease	Agammaglobulinemia	CD19 SLC39A7	6.63e-04	12	95	2	C0001768
Disease	Alzheimer's disease (is_implicated_in)	PSEN1 CYP19A1 LIPC GLUL	8.89e-04	132	95	4	DOID:10652 (is_implicated_in)
Disease	periprosthetic osteolysis, disease progression measurement	SFMBT2 OTUD7A	1.05e-03	15	95	2	EFO_0008336, EFO_0009761
Disease	Inborn Errors of Metabolism	PLA2G7 CES1	1.35e-03	17	95	2	C0025521
Disease	Sjogren's syndrome (implicated_via_orthology)	CYP19A1 THBS1	1.35e-03	17	95	2	DOID:12894 (implicated_via_orthology)
Disease	low affinity immunoglobulin gamma Fc region receptor II-a measurement	FCGR2C FCGR2B	1.35e-03	17	95	2	EFO_0021969
Disease	breast cancer (is_implicated_in)	CYP19A1 MAP3K1 UGT1A1 LHCGR	1.43e-03	150	95	4	DOID:1612 (is_implicated_in)
Disease	low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	CES1 LIPC PEMT FCGR2B	1.53e-03	153	95	4	EFO_0004611, EFO_0020946
Disease	Neutropenia	UGT1A1 FCGR2B	2.07e-03	21	95	2	C0027947
Disease	Dystonia	PSEN1 L2HGDH SLC46A1	2.73e-03	86	95	3	C0013421
Disease	low affinity immunoglobulin gamma Fc region receptor II-b measurement	FCGR2C FCGR2B	2.93e-03	25	95	2	EFO_0021970
Disease	lysophosphatidylethanolamine 16:0 measurement	LIPC SLC28A1	3.17e-03	26	95	2	EFO_0010366

Protein segments in the cluster

Peptide	Gene	Start	Entry
NRLPVMVWIHGGGLM	CES1	131	P23141
VISHMAVSGVGIWIA	ARHGEF10	1111	O15013
MEHGTLLAQPGLWTR	GRIK1	1	P39086
GHMLLWTAVLFLAPV	FCGR2B	26	P31994
LRVEPGVMLGIWHTV	ABHD12B	101	Q7Z5M8
RSALMWFGVIFIRHG	AKTIP	101	Q9H8T0
LSPILAHGGVRFMWI	AP1M1	46	Q9BXS5
LAMGIWIKFRHSPGL	ABCB6	136	Q9NP58
ALEWVAIMHGLGALL	DNHD1	1241	Q96M86
AIMHGLGALLEVWLT	DNHD1	1246	Q96M86
QVHVGPMRGTSVGWL	CHDH	421	Q8NE62
RHGLMFEVVDLRWGI	NWD1	21	Q149M9
LGAGWRLGFLGLLHM	GUF1	396	Q8N442
DIKRALGIHLLWGTM	OR7A5	296	Q15622
MGIPGLEGLHTWISI	OR52Z1P	1	P0C646
LPWIMNLIGRFHRVS	ANO6	626	Q4KMQ2
TVLGLALWTGMHTIA	ANKFY1	591	Q9P2R3
AGMLASLLGGHWLRA	SLC46A1	191	Q96NT5
RHAILIMLGGWLFSS	LHCGR	481	P22888
AHVRRVLGAVWGLAM	NMUR1	176	Q9HB89
HWSRLLFLLGMLIIG	SLC24A1	21	O60721
LAWLLHSGVMGAVVA	GHITM	191	Q9H3K2
LGVHFTPRMDGSIWL	L2HGDH	311	Q9H9P8
WDDGLRHLVMLSFGP	CRB2	721	Q5IJ48
APMGALWGLVHDFVV	MMS19	11	Q96T76
GHMLLWTAVLFLAPV	FCGR2C	26	P31995
RLGTHWDIFLMIIAG	PCNX2	1216	A6NKB5
VWIAGGLSGLMHAAI	OR14J1	146	Q9UGF5
LLMGVVWMGGFLHAT	OR4C46	141	A6NHA9
GIMAVTWGIGFLHSV	OR4F5	136	Q8NH21
ALSWMGGFIHSIIQV	OR4M1	146	Q8NGD0
EIGGPAFRIMWAVHN	MAP3K7	231	O43318
GFNSSLPLVMIIHGW	LIPC	76	P11150
VLMGGLIWFLFQRHR	LY75	1681	O60449
HVFGPGSLSLRRGMW	ASIC3	31	Q9UHC3
VAPMRGGEITAHWLL	HEG1	446	Q9ULI3
SLGMWGFHDRDLVLR	OTUD7A	216	Q8TE49
GIMAVAWGIGFLHSV	OR4F17	136	Q8NGA8
VGLFLMGNHTTAWRR	DDX11	901	Q96FC9
GMWLTYALGVGLLHI	ORMDL1	21	Q9P0S3
MAGAHGLWMLLLGRT	SLC2A6	126	Q9UGQ3
MVVVSRWYGGILLGP	IMPACT	261	Q9P2X3
LGTHWLMGNILRLLF	PLA2G7	111	Q13093
LGWAIMHASPTGLLL	PEMT	151	Q9UBM1
LGFLGGVSWAMLVAR	PAPOLA	241	P51003
ARTLMGWGVRHITFV	ATG7	371	O95352
HRVTMGTAALGPVWA	C1QTNF6	16	Q9BXI9
LGMVGTLITTILPHW	CLDN14	16	O95500
IGPLISHGRFLWMGI	CYP19A1	56	P11511
LGIHMRPLAIWLFIF	CD19	71	P15391
WPLTVFMGHIGGHSL	FZD3	11	Q9NPG1
SHRMWGRLVGLVYIL	COX15	151	Q7KZN9
RPVMVWVHGGALITG	CES3	141	Q6UWW8
PWSFTGAVILMIAHG	MT-ND4	306	P03905
LIGIPGLEDFHMWIS	OR52J3	16	Q8NH60
MLVGVAWLGGFLHSL	OR4C3	141	Q8NH37
GIMAVAWGIGFLHSV	OR4F4	136	Q96R69
MAAAVLGQLGALWIH	MRPL22	1	Q9NWU5
LFIEWMAGGSVAHLL	MAP3K1	1321	Q13233
GISMGDHLWVARFIL	GLUL	211	P15104
GRVLLWDIGHGLMVG	TAF5	691	Q15542
GMAVAIILFGWIIGV	TMEM178B	176	H3BS89
VVLGHLRGPADSGWM	ACAA1	6	P09110
GVVGMISIHWKGPLR	PSEN1	206	P49768
LMIAFGLLWGHLLRI	TMCO3	361	Q6UWJ1
VARVMWHPSGRFLGT	PRPF4	326	O43172
VLGMVGTALLASLWH	SLC52A2	86	Q9HAB3
SIGAIMWHVIARDFG	SIPA1L2	851	Q9P2F8
PLSLAFLVLGGIWMH	IL1R2	356	P27930
GMRLVHLGTSSRWAV	SLC39A2	211	Q9NP94
QILVGSSLGGWLMLH	ABHD10	146	Q9NUJ1
MRLYHATGWGVPVGI	ADGRD2	761	Q7Z7M1
RMLLIWLHGVATAGE	ANKDD1A	461	Q495B1
WTSTLLQGLGHMLLG	CIDEB	181	Q9UHD4
MGLAWGLGVLFLMHV	THBS1	1	P07996
WMLFGLHGTITQIRI	NEURL1	431	O76050
GKGLAMLHVTRGVWG	TMEM143	11	Q96AN5
TVLLMAVGIFGHWRT	THAP9	321	Q9H5L6
GGLLVHFWIVFVMPR	TMPRSS7	171	Q7RTY8
GFWVVLARGVMLVGG	SLC5A5	201	Q92911
IHGLFGIKVWDGLME	PLCXD2	131	Q0VAA5
MARGLGAPHWVAVGL	SLC39A7	1	Q92504
TVYPGLMITAGLIHW	STT3B	141	Q8TCJ2
ADWQIRMVFVGHTGP	WDR97	321	A6NE52
VSVKGRLMWLHLEGL	SFMBT2	431	Q5VUG0
LLIPVDGSHWLSMLG	UGT1A1	31	P22309
GRTGARVWLFIGFML	TMEM50B	91	P56557
LVGHSMWLRSVLGLP	MYCBPAP	781	Q8TBZ2
SIWHMLIAGSVGFLL	TMEM8B	411	A6NDV4
DLMLRHGWRTGAIIP	NT5DC2	366	Q9H857
PFIRNIIMHEGSWGI	PIGN	71	O95427
REHMQLFRWIGTGLL	SLC28A1	76	O00337
ALPMTIRHSWEGGAI	nan	681	Q3C1V9
LLGLSWLHRGGAMGL	TMEM187	66	Q14656
TLIMWRRGHGPQSFI	TSPYL6	326	Q8N831
RTSGRGPWEMVLVVH	SLX1A	56	Q9BQ83
GVRWGMELLTLPHGR	SH2D3C	616	Q8N5H7
WHVTIPGSMLIITGL	TMEM72	111	A0PK05
TMVGHRTEVWGLVLL	WDR3	186	Q9UNX4
QMGADRGPHVVLWTL	TMEM169	151	Q96HH4
GLEGAMGHRTLVLPW	PVRIG	16	Q6DKI7
GPLGHTRRFGQFWMV	VWA7	556	Q9Y334
WVIELGGTGLQIAHM	WDR87	136	Q6ZQQ6
MGFLGTGTWILVLVL	SCG3	1	Q8WXD2
MWTGGCRRIPVLVFH	TTLL5	31	Q6EMB2
WVVGLLSRGMAEHAP	NAT8	16	Q9UHE5