Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesspositive regulation of nuclear-transcribed mRNA poly(A) tail shortening

TNRC6B TNRC6C

8.92e-0514212GO:0060213
GeneOntologyBiologicalProcesspositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

TNRC6B TNRC6C

1.17e-0416212GO:1900153
GeneOntologyBiologicalProcessregulation of nuclear-transcribed mRNA poly(A) tail shortening

TNRC6B TNRC6C

1.17e-0416212GO:0060211
MousePhenoabnormal auditory tube morphology

GAS2L2 CHD7

5.61e-059182MP:0003330
MousePhenobiliary cyst

GAS2L2 AUTS2

8.55e-0511182MP:0003266
MousePhenoabnormal Mullerian duct topology

GAS2L2 AUTS2

1.41e-0414182MP:0013852
MousePhenoabnormal artery morphology

GAS2L2 AUTS2 BCAS3 CHD7 FN1

1.84e-04440185MP:0002191
MousePhenoembryo tumor

GAS2L2 AUTS2

2.11e-0417182MP:0014018
DomainAgo_hook

TNRC6B TNRC6C

3.61e-063212PF10427
DomainTNRC6_PABC-bd

TNRC6B TNRC6C

3.61e-063212IPR032226
DomainArgonaute_hook_dom

TNRC6B TNRC6C

3.61e-063212IPR019486
DomainTNRC6-PABC_bdg

TNRC6B TNRC6C

3.61e-063212PF16608
DomainRRM

TNRC6B DAZL TNRC6C

2.08e-03230213PS50102
DomainUBA-like

TNRC6B TNRC6C

2.33e-0364212IPR009060
Domain-

TNRC6B DAZL TNRC6C

2.46e-032442133.30.70.330
DomainNucleotide-bd_a/b_plait

TNRC6B DAZL TNRC6C

2.88e-03258213IPR012677
PathwayREACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS

TNRC6B TNRC6C

2.53e-057162M46421
PathwayREACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION

TNRC6B TNRC6C

4.33e-059162M27810
PathwayREACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION

TNRC6B TNRC6C

4.33e-059162M46436
PathwayREACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS

TNRC6B TNRC6C

5.41e-0510162M48013
PathwayREACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION

TNRC6B TNRC6C

9.35e-0513162M46434
PathwayREACTOME_SIGNALING_BY_ALK_IN_CANCER

RNF213 TNRC6C FN1

1.46e-0493163M42521
PathwayREACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY

TNRC6B TNRC6C

1.63e-0417162M27788
PathwayREACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_APOPTOSIS

TNRC6B TNRC6C

2.04e-0419162M48238
PathwayREACTOME_TGFBR3_EXPRESSION

TNRC6B TNRC6C

4.49e-0428162M48253
PathwayREACTOME_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION

TNRC6B TNRC6C

5.87e-0432162M48012
PathwayREACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY

TNRC6B TNRC6C

5.87e-0432162M27900
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_NPAS4

TNRC6B TNRC6C

6.63e-0434162M46422
PathwayREACTOME_ONCOGENE_INDUCED_SENESCENCE

TNRC6B TNRC6C

7.03e-0435162M27190
PathwayREACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX

TNRC6B TNRC6C

7.86e-0437162M29790
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_VENTX

TNRC6B TNRC6C

9.65e-0441162M29748
PathwayREACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING

TNRC6B TNRC6C

1.27e-0347162M29777
PathwayREACTOME_SIGNALING_BY_TGFBR3

TNRC6B TNRC6C

1.38e-0349162M48250
PathwayREACTOME_ADHERENS_JUNCTIONS_INTERACTIONS

TNRC6B TNRC6C

1.92e-0358162M11980
PathwayREACTOME_CA2_PATHWAY

TNRC6B TNRC6C

2.20e-0362162M27321
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1

AUTS2 TNRC6B TNRC6C

2.23e-03237163M27786
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_MECP2

TNRC6B TNRC6C

2.27e-0363162M27862
PathwayREACTOME_TP53_REGULATES_METABOLIC_GENES

TNRC6B TNRC6C

3.99e-0384162M27495
Pubmed

Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.

TNRC6B TNRC6C

1.25e-06323234108231
Pubmed

Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.

TNRC6B TNRC6C

1.25e-06323216880270
Pubmed

Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.

TNRC6B TNRC6C

1.25e-06323231670606
Pubmed

Proximity labeling reveals dynamic changes in the SQSTM1 protein network.

AUTS2 TNRC6B BCAS3 FAM222B TNRC6C

1.94e-0632223539098523
Pubmed

Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing.

TNRC6B TNRC6C

2.51e-06423221063388
Pubmed

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

AUTS2 TNRC6B FAM222B TNRC6C

2.91e-0615223438360978
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

AUTS2 TNRC6B BABAM2 RNF213 ZNF793 BCAS3 TNRC6C EHF

3.05e-06148923828611215
Pubmed

Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps.

TNRC6B TNRC6C

4.18e-06523219838187
Pubmed

The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.

TNRC6B TNRC6C

8.77e-06723219383768
Pubmed

Functional dissection of the human TNRC6 (GW182-related) family of proteins.

TNRC6B TNRC6C

8.77e-06723219470757
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

AUTS2 TNRC6B CHD7 TNRC6C

1.37e-0522523412168954
Pubmed

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.

TNRC6B TNRC6C

3.79e-051423219716330
Pubmed

GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.

TNRC6B TNRC6C

4.37e-051523221981923
Pubmed

High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.

CR2 TNRC6B FAM222B TNRC6C

4.62e-0530723437499664
Pubmed

Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing.

AUTS2 TNRC6B

6.36e-051823230111840
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

TNRC6B BCAS3 CHD7 FN1

8.83e-0536323414691545
Pubmed

Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm.

TNRC6B TNRC6C

9.59e-052223222187428
Pubmed

Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung.

TNRC6B TNRC6C

1.05e-042323228811219
Pubmed

Structure and evolution of the Smith-Magenis syndrome repeat gene clusters, SMS-REPs.

CCDC144A CCDC144CP

1.68e-042923211997339
Pubmed

The sperm-associated antigen 6 interactome and its role in spermatogenesis.

BABAM2 DAZL NUFIP1

3.00e-0419923331146259
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

RNF213 BCAS3 FN1

3.71e-0421423322199357
Cytoband17q25.3

RNF213 TNRC6C

1.18e-0310123217q25.3
Cytoband17p11.2

CCDC144A CCDC144CP

2.87e-0315923217p11.2
CytobandEnsembl 112 genes in cytogenetic band chr17p11

CCDC144A CCDC144CP

4.63e-03203232chr17p11
CytobandEnsembl 112 genes in cytogenetic band chr17q25

RNF213 TNRC6C

1.03e-02307232chr17q25
GeneFamilyAtaxins|Trinucleotide repeat containing

TNRC6B TNRC6C

1.65e-0425142775
CoexpressionGSE33424_CD161_INT_VS_NEG_CD8_TCELL_UP

RNF213 SCAMP2 CHD7 NUFIP1

2.60e-05200234M8554
Diseaselymphocyte count

AUTS2 TNRC6B BCAS3 CHD7 NUFIP1 FN1

7.18e-041464236EFO_0004587
Diseasesystemic scleroderma

CR2 CHD7

1.99e-0385232EFO_0000717
DiseaseUterine leiomyoma

TNRC6B BABAM2

2.28e-0391232HP_0000131
Diseaseprostate carcinoma

TNRC6B RNF213 CHD7 EHF

4.63e-03891234EFO_0001663
Diseasebilirubin measurement

BCAS3 ROM1 FAM222B

4.73e-03442233EFO_0004570
Diseaseessential tremor

BABAM2 FAM222B

5.01e-03136232EFO_0003108
Diseasegait measurement

AUTS2 SPATA31E1

6.06e-03150232EFO_0007680
Diseaseautism spectrum disorder (implicated_via_orthology)

SCAMP2 CHD7

6.21e-03152232DOID:0060041 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
SLPQNNNPDWHPTNL

CCDC144CP

131

Q8IYA2
QWNELQPPFNANHPL

BCAS3

661

Q9H6U6
PWAQLHPSPQNTPQK

CHD7

536

Q9P2D1
QPLWNNILPTPNSDS

FAM222B

451

Q8WU58
PSVQNFSNPHEPWNR

AUTS2

781

Q8WXX7
PQSQCQSDHQWNPPL

CR2

951

P20023
PSALQNLASWNPSNP

BABAM2

96

Q9NXR7
MNNLNDPPNWNIRPN

CCDC127

1

Q96BQ5
SQPNSHPIQWNAPQP

FN1

621

P02751
PQPPEGLQPHWLNQA

GAS2L2

856

Q8NHY3
LNPGNNLLHQPPAWT

EHF

11

Q9NZC4
SLPQNNNPDWHPTNL

CCDC144B

131

Q3MJ40
TQWTPPPQNHLGNKN

ASIC5

486

Q9NY37
FNHPPPPQFQNVWTN

DAZL

131

Q92904
SLPQNNNPDWHPTNL

CCDC144A

131

A2RUR9
INLNLNPNANPAAWP

TNRC6C

96

Q9HCJ0
PQVPHLNQNAWNNLE

ENDOG

166

Q14249
ANLHVRQNNWPPLPS

SCAMP2

111

O15127
AQPQHFTPAWPQSQP

SPATA31E1

501

Q6ZUB1
PWPQDTALPHSQAQQ

RNF213

126

Q63HN8
PSNWNPCGKNLNHNL

ZNF793

136

Q6ZN11
SQPQPSGQPWNFHAS

NUFIP1

101

Q9UHK0
HPLFDPRQPNQNLWA

ROM1

236

Q03395
NFNPNSNPSAWPALV

TNRC6B

301

Q9UPQ9