Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	Cul3-RING ubiquitin ligase complex	SPOPL KCTD5 KCTD2	1.64e-04	39	57	3	GO:0031463
GeneOntologyCellularComponent	alpha-beta T cell receptor complex	TRA TRAC	4.74e-04	12	57	2	GO:0042105
Domain	MARK/par1	MARK1 MARK2	5.66e-05	4	58	2	IPR033624
Domain	KA1_dom	MARK1 MARK2	9.42e-05	5	58	2	IPR001772
Domain	KA1	MARK1 MARK2	9.42e-05	5	58	2	PF02149
Domain	KA1	MARK1 MARK2	9.42e-05	5	58	2	PS50032
Domain	-	MARK1 MARK2	9.42e-05	5	58	2	3.30.310.80
Domain	Serpin_CS	SERPINE2 SERPINB13 SERPINB12	1.32e-04	32	58	3	IPR023795
Domain	Serpin_dom	SERPINE2 SERPINB13 SERPINB12	1.89e-04	36	58	3	IPR023796
Domain	KA1/Ssp2_C	MARK1 MARK2	1.97e-04	7	58	2	IPR028375
Domain	SERPIN	SERPINE2 SERPINB13 SERPINB12	2.05e-04	37	58	3	SM00093
Domain	SERPIN	SERPINE2 SERPINB13 SERPINB12	2.05e-04	37	58	3	PS00284
Domain	Serpin	SERPINE2 SERPINB13 SERPINB12	2.22e-04	38	58	3	PF00079
Domain	Serpin_fam	SERPINE2 SERPINB13 SERPINB12	2.40e-04	39	58	3	IPR000215
Domain	ERAP1-like_C_dom	ERAP1 LNPEP	2.62e-04	8	58	2	IPR024571
Domain	ERAP1_C	ERAP1 LNPEP	2.62e-04	8	58	2	PF11838
Domain	Peptidase_M1	ERAP1 LNPEP	6.13e-04	12	58	2	IPR001930
Domain	Peptidase_M1	ERAP1 LNPEP	7.23e-04	13	58	2	PF01433
Domain	Peptidase_M1_N	ERAP1 LNPEP	7.23e-04	13	58	2	IPR014782
Domain	UBA	MARK1 MARK2	3.90e-03	30	58	2	SM00165
Domain	-	KPNA7 RIF1 LRBA ECPAS	4.99e-03	222	58	4	1.25.10.10
Domain	UBA	MARK1 MARK2	5.58e-03	36	58	2	PF00627
Pubmed	Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis.	SERPINB13 SERPINB12	2.93e-06	2	60	2	14770295
Pubmed	A structural basis for immunodominant human T cell receptor recognition.	TRA TRAC	2.93e-06	2	60	2	12796775
Pubmed	Differential role for CD277 as a co-regulator of the immune signal in T and NK cells.	BTN3A2 BTN3A1	2.93e-06	2	60	2	21918970
Pubmed	The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies.	BTN3A2 BTN3A1	2.93e-06	2	60	2	22846996
Pubmed	CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells.	BTN3A2 BTN3A1	2.93e-06	2	60	2	21113407
Pubmed	Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2.	MARK1 MARK2	2.93e-06	2	60	2	16803889
Pubmed	Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1.	ERAP1 LNPEP	2.93e-06	2	60	2	20592285
Pubmed	TRAC variants associate with IgA nephropathy.	TRA TRAC	2.93e-06	2	60	2	19470682
Pubmed	The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia.	TRA TRAC	2.93e-06	2	60	2	3875483
Pubmed	Identification of 33 polymorphisms in the adipocyte-derived leucine aminopeptidase (ALAP) gene and possible association with hypertension.	ERAP1 LNPEP	8.77e-06	3	60	2	11857741
Pubmed	Regulation of the human leukocyte-derived arginine aminopeptidase/endoplasmic reticulum-aminopeptidase 2 gene by interferon-gamma.	ERAP1 LNPEP	8.77e-06	3	60	2	15691326
Pubmed	Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset.	BTN3A2 BTN3A1	8.77e-06	3	60	2	22767497
Pubmed	KCTD Proteins Have Redundant Functions in Controlling Cellular Growth.	KCTD5 KCTD2	8.77e-06	3	60	2	38732215
Pubmed	Cell-Specific and Variant-Linked Alterations in Expression of ERAP1, ERAP2, and LNPEP Aminopeptidases in Psoriasis.	ERAP1 LNPEP	8.77e-06	3	60	2	36716917
Pubmed	The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance.	TRA TRAC	8.77e-06	3	60	2	12429093
Pubmed	Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.	ERAP1 LNPEP	8.77e-06	3	60	2	21314638
Pubmed	MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption.	MARK1 MARK2	8.77e-06	3	60	2	9108484
Pubmed	The oxytocinase subfamily of M1 aminopeptidases.	ERAP1 LNPEP	8.77e-06	3	60	2	16054015
Pubmed	Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line.	TRA TRAC	8.77e-06	3	60	2	3873654
Pubmed	A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy.	ERAP1 LNPEP	1.75e-05	4	60	2	24957906
Pubmed	Prothrombotic gene polymorphisms and atherothrombotic cerebral infarction.	SERPINE2 F5	1.75e-05	4	60	2	12859287
Pubmed	Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2.	BTN3A2 BTN3A1	1.75e-05	4	60	2	39142074
Pubmed	Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells.	MARK1 MARK2	1.75e-05	4	60	2	10542369
Pubmed	Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure.	ERAP1 LNPEP	1.75e-05	4	60	2	17999179
Pubmed	Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex.	BTN3A2 BTN3A1	1.75e-05	4	60	2	9382921
Pubmed	Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology.	BTN3A2 BTN3A1	2.92e-05	5	60	2	29339503
Pubmed	Normal embryonic and germ cell development in mice lacking alpha 1,3-fucosyltransferase IX (Fut9) which show disappearance of stage-specific embryonic antigen 1.	MDN1 FUT9	2.92e-05	5	60	2	15121843
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	MARK1 RALGPS2 MARK2 PRAG1	3.00e-05	102	60	4	15778465
Pubmed	Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease.	MARK1 MARK2	4.37e-05	6	60	2	23666762
Pubmed	Update of the human and mouse SERPIN gene superfamily.	SERPINE2 SERPINB13 SERPINB12	5.73e-05	43	60	3	24172014
Pubmed	The cluster of BTN genes in the extended major histocompatibility complex.	BTN3A2 BTN3A1	6.11e-05	7	60	2	11170752
Pubmed	Association of defective HLA-I expression with antigen processing machinery and their association with clinicopathological characteristics in Kazak patients with esophageal cancer.	TAPBPL ERAP1	6.11e-05	7	60	2	21362330
Pubmed	Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions.	MARK1 MARK2	8.14e-05	8	60	2	22298430
Pubmed	High loading dose of clopidogrel is unable to satisfactorily inhibit platelet reactivity in patients with glycoprotein IIIA gene polymorphism: a genetic substudy of PRAGUE-8 trial.	MARK2 F5	8.14e-05	8	60	2	19530321
Pubmed	Identification of 14-3-3epsilon substrates from embryonic murine brain.	DLGAP3 PANK2 MARK1 MARK2	8.20e-05	132	60	4	16944949
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	DLGAP3 MARK1 ADGRL1 SYNPO MAP3K13 MARK2	9.83e-05	430	60	6	32581705
Pubmed	Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner.	CACNA1S LNPEP	1.05e-04	9	60	2	12080061
Pubmed	Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.	MARK1 LNPEP RALGPS2 MARK2 ECPAS SLC7A11	1.54e-04	467	60	6	30194290
Pubmed	Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus.	SERPINB13 SERPINB12	1.59e-04	11	60	2	15203215
Pubmed	Common variants on chromosome 6p22.1 are associated with schizophrenia.	BTN3A2 BTN3A1	1.59e-04	11	60	2	19571809
Pubmed	Human Multisubunit E3 Ubiquitin Ligase Required for Heterotrimeric G-Protein β-Subunit Ubiquitination and Downstream Signaling.	KCTD5 KCTD2	1.91e-04	12	60	2	34342229
Pubmed	LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.	MARK1 MARK2	3.03e-04	15	60	2	14976552
Pubmed	Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.	MAP3K13 MARK2	3.46e-04	16	60	2	8274451
Pubmed	Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease.	CACNA1S LNPEP	3.91e-04	17	60	2	22153077
Pubmed	Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.	ARRDC4 MARK1	3.91e-04	17	60	2	21897333
Pubmed	A 1.1-Mb transcript map of the hereditary hemochromatosis locus.	BTN3A2 BTN3A1	4.40e-04	18	60	2	9149941
Pubmed	A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development.	KCTD5 MUC19 KCTD2	4.67e-04	87	60	3	37495603
Pubmed	Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.	MARK1 MARK2	5.45e-04	20	60	2	18227155
Pubmed	The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.	ERAP1 LNPEP	6.02e-04	21	60	2	19578876
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	PANK2 MDN1 RAB3GAP2 C19orf47 RALGPS2 MARK2 PRAG1	6.87e-04	861	60	7	36931259
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	DLGAP3 UBE2O SERPINE2 MARK1 RAB3GAP2 ADGRL1 SYNPO SVOP	7.30e-04	1139	60	8	36417873
Pubmed	CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.	SERPINE2 KCTD5 SERPINB12 SYNPO ECPAS	7.77e-04	418	60	5	35338135
Pubmed	KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.	KCTD5 KCTD2	7.88e-04	24	60	2	23209302
Pubmed	Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.	TRA TRAC	7.88e-04	24	60	2	15489916
Pubmed	Adapters in lymphocyte signaling.	TRA TRAC	9.26e-04	26	60	2	11827988
Pubmed	14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.	MARK1 MARK2	1.23e-03	30	60	2	16306228
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	SCAP LNPEP TRAM1 RAB3GAP2 BTN3A2	1.28e-03	468	60	5	31056421
Pubmed	The mechanism of phospholipase C-gamma1 regulation.	TRA TRAC	1.32e-03	31	60	2	11048639
Pubmed	STK11 is required for the normal program of ciliated cell differentiation in airways.	MARK1 MARK2	1.32e-03	31	60	2	31636950
Pubmed	FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A.	KCTD5 KCTD2	1.32e-03	31	60	2	36159747
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	RIF1 MDN1 LRBA	1.46e-03	129	60	3	23022380
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	RIF1 MDN1 RAB3GAP2 MARK2	1.56e-03	288	60	4	23383273
Pubmed	Early embryonic expression of murine coagulation system components.	SERPINE2 F5	1.58e-03	34	60	2	11154109
Cytoband	1q25.2	CLEC20A RALGPS2	7.62e-04	31	60	2	1q25.2
Cytoband	5q15	ERAP1 LNPEP	1.27e-03	40	60	2	5q15
Cytoband	Ensembl 112 genes in cytogenetic band chr5q15	ERAP1 LNPEP	2.74e-03	59	60	2	chr5q15
Cytoband	1q41	MARK1 RAB3GAP2	3.41e-03	66	60	2	1q41
GeneFamily	Serpin peptidase inhibitors	SERPINE2 SERPINB13 SERPINB12	7.40e-05	37	40	3	739
GeneFamily	Butyrophilins\|V-set domain containing\|C2-set domain containing	BTN3A2 BTN3A1	4.92e-04	15	40	2	458
GeneFamily	Aminopeptidases\|CD molecules	ERAP1 LNPEP	6.36e-04	17	40	2	104
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	ARID4B SPOPL ARRDC4 RALGPS2 SP110	3.65e-06	173	60	5	d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCell	Mild-CD8+_T_activated\|World / Disease group and Cell class	LNPEP TRAC SP110 BTN3A2 BTN3A1	6.70e-06	196	60	5	79632190e44fcef9d7c11d9b9e37f2ebf0e6e255
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ATP13A4 SERPINE2 FUT9 TMC3 SLC7A11	7.39e-06	200	60	5	7a8160e6477708f22e48c609bf8f43f3715dcb03
Drug	Benzylpenicillin sodium [69-57-8]; Down 200; 11.2uM; MCF7; HT_HG-U133A	UBE2O SLC35C1 RALGPS2 KCTD2 DDX43 SLC7A11	1.00e-05	191	59	6	6839_DN
Drug	Enoxacin [74011-58-8]; Up 200; 12.4uM; MCF7; HT_HG-U133A	RAB3GAP2 RALGPS2 MC5R FUT9 MARK2 F5	1.16e-05	196	59	6	5251_UP
Drug	Florfenicol [73231-34-2]; Up 200; 11.2uM; MCF7; HT_HG-U133A	ERAP1 MARK1 RAB3GAP2 ADGRL1 MARK2 F5	1.23e-05	198	59	6	6460_UP
Disease	visual impairment and progressive phthisis bulbi (implicated_via_orthology)	MARK1 MARK2	2.27e-05	4	58	2	DOID:0070356 (implicated_via_orthology)
Disease	endoplasmic reticulum aminopeptidase 1 measurement	ERAP1 LNPEP	7.92e-05	7	58	2	EFO_0008119
Disease	severe pre-eclampsia (is_marker_for)	ERAP1 LNPEP	1.06e-04	8	58	2	DOID:13129 (is_marker_for)
Disease	renal sinus adipose tissue measurement	GLT1D1 L3MBTL3	2.92e-04	13	58	2	EFO_0004864
Disease	interferon gamma measurement, platelet-derived growth factor BB measurement, interleukin 4 measurement, interleukin 10 measurement, stromal cell-derived factor 1 alpha measurement, interleukin-6 measurement, interleukin 12 measurement, interleukin 17 measurement, vascular endothelial growth factor measurement, fibroblast growth factor basic measurement, granulocyte colony-stimulating factor measurement	SERPINE2 F5	4.48e-04	16	58	2	EFO_0004750, EFO_0004753, EFO_0004762, EFO_0004810, EFO_0008130, EFO_0008142, EFO_0008165, EFO_0008174, EFO_0008184, EFO_0008264, EFO_0008293
Disease	inflammatory biomarker measurement	SERPINE2 F5	1.20e-03	26	58	2	EFO_0004872

Protein segments in the cluster

Peptide	Gene	Start	Entry
KWSFQMSDLENMTSA	ARID4B	1216	Q4LE39
ITCMKVSDMFAAWSD	CSMD2	381	Q7Z408
ETMVSVTMATSEWIQ	C19orf47	36	Q8N9M1
PTMSAETMELKWVSS	BTN3A1	56	O00481
KMFEATTWEMAFSGD	ATP13A4	551	Q4VNC1
WKDMNATEQVHTATM	ADGRL1	636	O94910
SSIASQFSMDMSWLT	ARRDC4	326	Q8NCT1
EMENVKKATATTTWM	L3MBTL3	51	Q96JM7
MMWNTFLVKRFSAAT	RAB3GAP2	1056	Q9H2M9
ADSFTFNPSKWMMVH	HDC	296	P19113
EAVWMVANFATGATM	KPNA7	386	A9QM74
MFMSFWSSTVTTNPE	MDN1	3016	Q9NU22
ISSMLWTNMAISSVA	MDN1	3111	Q9NU22
MASVMAVTEPKWVSV	FICD	6	Q9BVA6
WIFSPMESASSVLKM	FUT9	36	Q9Y231
AMTSIWNALVTDKSM	ECPAS	1141	Q5VYK3
HQEGVDVKTMMNTWT	ERAP1	511	Q9NZ08
STSSMPKMLAIFWFN	OR51E1	76	Q8TCB6
MSITKAWNSSSVTMF	OR5A1	1	Q8NGJ0
EKTSQAFANSWEMMS	MUC19	971	Q7Z5P9
QMWRSHSTKTVMDFV	LRBA	1331	P50851
STTAMKLFDDWMASN	LNPEP	836	Q9UIQ6
HISTKTIDSWMSIMV	SERPINE2	271	P07093
KNWTQVTEFVMMGFA	OR6Q1	6	Q8NGQ2
WAVASSFGNMMSKEK	PANK2	466	Q9BZ23
DKSTKMSFAGTVAWM	MAP3K13	306	O43283
EETKSFLWWTSNMMV	SLC35C1	316	Q96A29
VAFTESMKEMAQAQW	GLT1D1	111	Q96MS3
SVFQVLTGEDWTSMM	CACNA1S	606	Q13698
SVKRSAWHTMMVSQG	DLGAP3	326	O95886
PTMSAETMELKWVSS	BTN3A2	56	P78410
RFTWSMKTTSSMDPN	MARK1	701	Q9P0L2
TWSMKTTSSMEPNEM	MARK2	696	Q7KZI7
ADMLVSMSSAWETIT	MC5R	81	P33032
MVSTMSDGWKFEQLV	KCTD5	171	Q9NXV2
SSESWSIMKNMATEL	SCAP	386	Q12770
VSVFANMLVTNFWMS	CLDN18	136	P56856
EEKWSHMQTFLQSMS	DDX43	471	Q9NXZ2
STSNKNVSVIGWMVM	RALGPS2	511	Q86X27
ELTQMVSTMSDGWKF	KCTD2	196	Q14681
FATEKMFRMLTNIWT	TAS2R14	76	Q9NYV8
TSVVFVGMMSSSTLW	SVOP	126	Q8N4V2
MSIEEMATKNNTSHW	TMC3	421	Q7Z5M5
MTETTVKTAAWFMAN	TAPBPL	131	Q9BX59
VKTAAWFMANMQVSG	TAPBPL	136	Q9BX59
VTVTMDNVGTWMLTS	F5	651	P12259
SAQFWNATFAKVMML	RIF1	931	Q5UIP0
QDWDVVKAGQMMTAS	SYNPO	106	Q8N3V7
DSTWNSEVMMRVQKA	SP110	401	Q9HB58
MVAWSSSENMSEESV	SERPINB12	281	Q96P63
MRSMDFKSNSAVAWS	TRAC	51	P01848
WIGASIMTSMSSFKQ	ACTRT1	341	Q8TDG2
FWDKKMQSRVTFDTM	CNBD2	61	Q96M20
GQTFMRFDQVMTWSS	CLEC20A	161	Q6ZU45
VMVLNSMSVSWSARI	SLC7A11	176	Q9UPY5
FWMNKSTSKSVQMMT	SERPINB13	201	Q9UIV8
MRSMDFKSNSAVAWS	TRA	186	P0DTU3
QATDIMETSGWKSMI	SPOPL	346	Q6IQ16
MSGWIATSKTRMQDF	STAG3L4	1	Q8TBR4
VEVVTTMTSADVMWQ	UBE2O	546	Q9C0C9
VKPTMMSSEASDVWT	PRAG1	86	Q86YV5
LASICVTQAFMMWKF	TRAM1	301	Q15629