Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-19 ERVK-25 PGA3	2.59e-04	37	67	3	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-19 ERVK-25 PGA3	2.80e-04	38	67	3	GO:0070001
GeneOntologyBiologicalProcess	specification of loop of Henle identity	IRX3 IRX1 IRX2	1.43e-07	4	69	3	GO:0072086
GeneOntologyBiologicalProcess	specification of nephron tubule identity	IRX3 IRX1 IRX2	3.57e-07	5	69	3	GO:0072081
GeneOntologyBiologicalProcess	proximal/distal pattern formation involved in nephron development	IRX3 IRX1 IRX2	3.57e-07	5	69	3	GO:0072047
GeneOntologyBiologicalProcess	pattern specification involved in kidney development	IRX3 IRX1 IRX2	1.98e-06	8	69	3	GO:0061004
GeneOntologyBiologicalProcess	renal system pattern specification	IRX3 IRX1 IRX2	1.98e-06	8	69	3	GO:0072048
GeneOntologyBiologicalProcess	loop of Henle development	IRX3 IRX1 IRX2	4.23e-06	10	69	3	GO:0072070
GeneOntologyBiologicalProcess	proximal/distal pattern formation involved in metanephric nephron development	IRX1 IRX2	1.10e-05	2	69	2	GO:0072272
GeneOntologyBiologicalProcess	segment specification	IRX3 IRX1 IRX2	5.27e-05	22	69	3	GO:0007379
GeneOntologyBiologicalProcess	nephron tubule formation	IRX3 IRX1 IRX2	6.05e-05	23	69	3	GO:0072079
GeneOntologyBiologicalProcess	pattern specification involved in metanephros development	IRX1 IRX2	6.59e-05	4	69	2	GO:0072268
GeneOntologyBiologicalProcess	retina layer formation	AHI1 DSCAM IRX6	7.82e-05	25	69	3	GO:0010842
GeneOntologyBiologicalProcess	nephron tubule morphogenesis	AHI1 IRX3 IRX1 IRX2	2.07e-04	87	69	4	GO:0072078
GeneOntologyBiologicalProcess	nephron epithelium morphogenesis	AHI1 IRX3 IRX1 IRX2	2.26e-04	89	69	4	GO:0072088
GeneOntologyBiologicalProcess	retina morphogenesis in camera-type eye	AHI1 IRX5 DSCAM IRX6	2.36e-04	90	69	4	GO:0060042
GeneOntologyBiologicalProcess	nephron morphogenesis	AHI1 IRX3 IRX1 IRX2	2.46e-04	91	69	4	GO:0072028
GeneOntologyBiologicalProcess	proximal/distal pattern formation	IRX3 IRX1 IRX2	2.57e-04	37	69	3	GO:0009954
GeneOntologyBiologicalProcess	animal organ morphogenesis	FOXE1 AHI1 IRX5 DSCAM RIPPLY2 IRX3 IRX6 ADPRHL1 IRX1 MAPK1 IRX2 IRX4 RYR2	2.60e-04	1269	69	13	GO:0009887
GeneOntologyBiologicalProcess	renal tubule morphogenesis	AHI1 IRX3 IRX1 IRX2	2.68e-04	93	69	4	GO:0061333
GeneOntologyBiologicalProcess	nephron development	AHI1 IRX3 C5 IRX1 IRX2	2.93e-04	174	69	5	GO:0072006
GeneOntologyBiologicalProcess	neural retina development	AHI1 IRX5 DSCAM IRX6	3.81e-04	102	69	4	GO:0003407
GeneOntologyBiologicalProcess	nephron tubule development	AHI1 IRX3 IRX1 IRX2	5.07e-04	110	69	4	GO:0072080
GeneOntologyBiologicalProcess	kidney morphogenesis	AHI1 IRX3 IRX1 IRX2	5.25e-04	111	69	4	GO:0060993
GeneOntologyBiologicalProcess	renal tubule development	AHI1 IRX3 IRX1 IRX2	6.19e-04	116	69	4	GO:0061326
MousePheno	abnormal retina bipolar cell morphology	IRX5 DSCAM IRX6 CNGB1 AMIGO1	2.57e-07	37	53	5	MP:0006073
Domain	IRO	IRX5 IRX3 IRX6 IRX1 IRX2 IRX4	1.40e-15	6	65	6	SM00548
Domain	Iroquois_homeo	IRX5 IRX3 IRX6 IRX1 IRX2 IRX4	1.40e-15	6	65	6	IPR003893
Domain	Homeobox_KN	IRX5 MKX IRX3 IRX6 IRX1 IRX2 IRX4	8.39e-14	17	65	7	PF05920
Domain	Homeobox_KN_domain	IRX5 MKX IRX3 IRX6 IRX1 IRX2 IRX4	8.39e-14	17	65	7	IPR008422
Domain	Homeobox_CS	IRX5 MKX IRX3 IRX6 IRX1 IRX2 IRX4	3.71e-06	186	65	7	IPR017970
Domain	Homeobox	IRX5 MKX IRX3 IRX6 IRX1 IRX2 IRX4	1.66e-05	234	65	7	PF00046
Domain	HOMEOBOX_1	IRX5 MKX IRX3 IRX6 IRX1 IRX2 IRX4	1.76e-05	236	65	7	PS00027
Domain	HOX	IRX5 MKX IRX3 IRX6 IRX1 IRX2 IRX4	1.81e-05	237	65	7	SM00389
Domain	HOMEOBOX_2	IRX5 MKX IRX3 IRX6 IRX1 IRX2 IRX4	1.91e-05	239	65	7	PS50071
Domain	Homeobox_dom	IRX5 MKX IRX3 IRX6 IRX1 IRX2 IRX4	1.91e-05	239	65	7	IPR001356
Domain	-	IRX5 MKX IRX3 IRX6 IRX1 IRX2 IRX4	5.59e-05	283	65	7	1.10.10.60
Domain	Homeodomain-like	IRX5 MKX IRX3 IRX6 IRX1 IRX2 IRX4	1.51e-04	332	65	7	IPR009057
Domain	DUF4599	SPATA31D4 SPATA31D3	7.70e-04	12	65	2	PF15371
Domain	DUF4599	SPATA31D4 SPATA31D3	7.70e-04	12	65	2	IPR027970
Domain	Prot_kinase_dom	GUCY2C RPS6KA3 DCLK2 MAPK1 KIT CDK10 ITK	1.52e-03	489	65	7	IPR000719
Domain	PROTEIN_KINASE_DOM	GUCY2C RPS6KA3 DCLK2 MAPK1 KIT CDK10 ITK	1.59e-03	493	65	7	PS50011
Domain	Protein_kinase_ATP_BS	RPS6KA3 DCLK2 MAPK1 KIT CDK10 ITK	2.02e-03	379	65	6	IPR017441
Domain	Kinase-like_dom	GUCY2C RPS6KA3 DCLK2 MAPK1 KIT CDK10 ITK	2.71e-03	542	65	7	IPR011009
Domain	PROTEIN_KINASE_ATP	RPS6KA3 DCLK2 MAPK1 KIT CDK10 ITK	5.18e-03	459	65	6	PS00107
Domain	Ion_trans_dom	KCNU1 CNGB1 RYR2	7.35e-03	114	65	3	IPR005821
Domain	Ion_trans	KCNU1 CNGB1 RYR2	7.35e-03	114	65	3	PF00520
Pubmed	Comparison of Iroquois gene expression in limbs/fins of vertebrate embryos.	IRX5 IRX3 IRX6 IRX1 IRX2 IRX4	5.34e-17	6	70	6	20408909
Pubmed	Organization of mouse Iroquois homeobox genes in two clusters suggests a conserved regulation and function in vertebrate development.	IRX5 IRX3 IRX6 IRX1 IRX2 IRX4	5.34e-17	6	70	6	11042145
Pubmed	Iroquois homeobox 3 regulates odontoblast proliferation and differentiation mediated by Wnt5a expression.	IRX5 IRX3 IRX6 IRX1 IRX2 IRX4	5.34e-17	6	70	6	36773339
Pubmed	Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast.	IRX5 IRX3 IRX6 IRX1 IRX2 IRX4	5.34e-17	6	70	6	10370142
Pubmed	The prepattern transcription factor Irx3 directs nephron segment identity.	IRX5 IRX3 IRX6 IRX1 IRX2 IRX4	3.73e-16	7	70	6	17875669
Pubmed	The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice.	IRX5 IRX3 IRX6 IRX1 IRX2 IRX4	4.46e-15	9	70	6	14585979
Pubmed	Gene and cluster-specific expression of the Iroquois family members during mouse development.	IRX5 IRX3 IRX6 IRX1 IRX2 IRX4	4.46e-15	9	70	6	11520674
Pubmed	Sensitive nonradioactive detection of mRNA in tissue sections: novel application of the whole-mount in situ hybridization protocol.	IRX5 IRX3 IRX1 IRX2 IRX4	1.59e-12	8	70	5	11118473
Pubmed	Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart.	IRX5 IRX3 IRX1 IRX2 IRX4	1.31e-11	11	70	5	10926765
Pubmed	Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes.	IRX5 IRX6 IRX1 IRX2	1.50e-11	4	70	4	11435706
Pubmed	Iroquois genes influence proximo-distal morphogenesis during rat lung development.	IRX5 IRX3 IRX1 IRX2	7.51e-11	5	70	4	16299054
Pubmed	Expression of two novel mouse Iroquois homeobox genes during neurogenesis.	IRX5 IRX3 IRX1 IRX2	7.51e-11	5	70	4	10704856
Pubmed	Expression of Irx6 during mouse morphogenesis.	IRX5 IRX3 IRX6 IRX4	7.51e-11	5	70	4	11335133
Pubmed	Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity.	IRX5 IRF8 IRX3 IRX6 IRX1 IRX2	6.97e-10	49	70	6	35315772
Pubmed	Identification of a novel mouse Iroquois homeobox gene, Irx5, and chromosomal localisation of all members of the mouse Iroquois gene family.	IRX5 IRX3 IRX1 IRX2	1.05e-09	8	70	4	10822268
Pubmed	Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression.	IRX5 IRX3 IRX1 IRX2 IRX4	1.82e-09	26	70	5	11238910
Pubmed	Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system.	IRX3 IRX1 IRX2	7.81e-09	3	70	3	9486539
Pubmed	The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5 in Acute Myeloid Leukemia.	IRX5 IRX3 IRX1	7.81e-09	3	70	3	35328612
Pubmed	Wnt/β-catenin promotes gastric fundus specification in mice and humans.	IRX5 IRX3 IRX1 IRX2	4.51e-08	18	70	4	28052057
Pubmed	Primordial germ cell proliferation is impaired in Fused Toes mutant embryos.	IRX5 IRX3 IRX6 KIT	1.07e-07	22	70	4	20969841
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	ADAM18 RPS6KA3 GBGT1 PCSK7 CPM MAPK1 CDK10 DNASE2 PGA3 ITK CES2	2.27e-07	730	70	11	34857952
Pubmed	The mouse Fused toes (Ft) mutation is the result of a 1.6-Mb deletion including the entire Iroquois B gene cluster.	IRX5 IRX3 IRX6	4.34e-07	8	70	3	11956760
Pubmed	The fused toes locus is essential for somatic-germ cell interactions that foster germ cell maturation in developing gonads in mice.	IRX5 IRX3 IRX6	1.27e-06	11	70	3	21293032
Pubmed	Epithelial inactivation of Yy1 abrogates lung branching morphogenesis.	IRX5 IRX3 MAPK1 IRX2	1.75e-06	43	70	4	26329601
Pubmed	IRX3 and IRX5 Inhibit Adipogenic Differentiation of Hypertrophic Chondrocytes and Promote Osteogenesis.	IRX5 IRX3	3.99e-06	2	70	2	32662900
Pubmed	The Tec family kinase, IL-2-inducible T cell kinase, differentially controls mast cell responses.	KIT ITK	3.99e-06	2	70	2	18523250
Pubmed	The Iroquois homeobox proteins IRX3 and IRX5 have distinct roles in Wilms tumour development and human nephrogenesis.	IRX5 IRX3	3.99e-06	2	70	2	30246301
Pubmed	IRX2 activated by jumonji domain-containing protein 2A is crucial for cardiac hypertrophy and dysfunction in response to the hypertrophic stimuli.	KDM4A IRX2	3.99e-06	2	70	2	36181956
Pubmed	Linkage disequilibrium and the search for complex disease genes.	IRX5 IRX6	3.99e-06	2	70	2	11042143
Pubmed	Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease.	C5 KIT	3.99e-06	2	70	2	23071133
Pubmed	Loss of Iroquois homeobox transcription factors 3 and 5 in osteoblasts disrupts cranial mineralization.	IRX5 IRX3	3.99e-06	2	70	2	27453922
Pubmed	Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5.	IRX5 IRX3	3.99e-06	2	70	2	34083488
Pubmed	Canonical Wnt/β-catenin activity and differential epigenetic marks direct sexually dimorphic regulation of Irx3 and Irx5 in developing mouse gonads.	IRX5 IRX3	3.99e-06	2	70	2	32108023
Pubmed	A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host.	RPS6KA3 MAPK1	3.99e-06	2	70	2	35078976
Pubmed	A duplication on chromosome 16q12 affecting the IRXB gene cluster is associated with autosomal dominant cone dystrophy with early tritanopic color vision defect.	IRX5 IRX6	3.99e-06	2	70	2	33891002
Pubmed	Pax6 regulates the formation of the habenular nuclei by controlling the temporospatial expression of Shh in the diencephalon in vertebrates.	IRX3 IRX1 IRX2	6.23e-06	18	70	3	24528677
Pubmed	CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart.	IRX1 IRX2 IRX4	6.23e-06	18	70	3	28846746
Pubmed	The Iroquois homeobox gene, Irx5, is required for retinal cone bipolar cell development.	IRX5 IRX2 IRX4	7.39e-06	19	70	3	16182275
Pubmed	Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse.	IRX5 IRX3 IRX4	8.69e-06	20	70	3	11245568
Pubmed	Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules.	RPS6KA3 MAPK1 RYR2	8.69e-06	20	70	3	21421818
Pubmed	A Sall1-NuRD interaction regulates multipotent nephron progenitors and is required for loop of Henle formation.	IRX3 IRX1 IRX2	1.01e-05	21	70	3	28760814
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	CLN8 AHI1 GBP7 RPS6KA3 ITSN1 MKX FAM91A1 MAPK1 PFKL POGLUT2 MADD	1.03e-05	1084	70	11	11544199
Pubmed	Tie2 regulates endocardial sprouting and myocardial trabeculation.	IRX5 IRX3 IRX6 MAPK1	1.11e-05	68	70	4	31112136
Pubmed	Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning.	IRX3 IRX1 IRX2	1.17e-05	22	70	3	15789444
Pubmed	Altered ERK/MAPK signaling in the hippocampus of the mrsk2_KO mouse model of Coffin-Lowry syndrome.	RPS6KA3 MAPK1	1.20e-05	3	70	2	21838783
Pubmed	Toll-like receptor 7 mediates pruritus.	TLR7 KIT	1.20e-05	3	70	2	21037581
Pubmed	Characterization of the p90 ribosomal S6 kinase 2 carboxyl-terminal domain as a protein kinase.	RPS6KA3 MAPK1	1.20e-05	3	70	2	12016217
Pubmed	Expression of c-Kit, p-ERK and cyclin D1 in malignant melanoma: an immunohistochemical study and analysis of prognostic value.	MAPK1 KIT	1.20e-05	3	70	2	21454057
Pubmed	Molecular crosstalk between p70S6k and MAPK cell signaling pathways.	RPS6KA3 MAPK1	1.20e-05	3	70	2	12054624
Pubmed	Isobavachalcone exerts anti‑proliferative and pro‑apoptotic effects on human liver cancer cells by targeting the ERKs/RSK2 signaling pathway.	RPS6KA3 MAPK1	1.20e-05	3	70	2	30942462
Pubmed	IRX3 and IRX5 collaborate during ovary development and follicle formation to establish responsive granulosa cells in the adult mouse†.	IRX5 IRX3	1.20e-05	3	70	2	32507881
Pubmed	PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.	RPS6KA3 MAPK1	1.20e-05	3	70	2	22213050
Pubmed	FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.	IRX5 IRX3	1.20e-05	3	70	2	26287746
Pubmed	The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation.	MAPK1 IRX2	1.20e-05	3	70	2	15133517
Pubmed	Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.	RPS6KA3 MAPK1 CDK10 ITK	1.92e-05	78	70	4	17192257
Pubmed	Notch signaling is essential for ventricular chamber development.	IRX5 IRX3 IRX4	2.21e-05	27	70	3	17336907
Pubmed	Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation.	IRX5 IRX3 IRX4	2.21e-05	27	70	3	24335256
Pubmed	Differences between germ-line and rearranged immunoglobulin V kappa coding sequences suggest a localized mutation mechanism.	IGKV6D-21 IGKV6-21	2.39e-05	4	70	2	6264318
Pubmed	RSK2 Maintains Adult Estrogen Homeostasis by Inhibiting ERK1/2-Mediated Degradation of Estrogen Receptor Alpha.	RPS6KA3 MAPK1	2.39e-05	4	70	2	32697984
Pubmed	Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells.	IRF8 KIT	2.39e-05	4	70	2	25398936
Pubmed	Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury.	MAPK1 KIT	2.39e-05	4	70	2	27468693
Pubmed	MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes.	MAPK1 KIT	2.39e-05	4	70	2	9440696
Pubmed	Pathogenesis of B-cell superantigen-induced immune complex-mediated inflammation.	C5 KIT	2.39e-05	4	70	2	16428769
Pubmed	Coffin-Lowry syndrome: a role for RSK2 in mammalian neurogenesis.	RPS6KA3 MAPK1	2.39e-05	4	70	2	20832397
Pubmed	Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT.	MAPK1 KIT	2.39e-05	4	70	2	21084381
Pubmed	Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1.	RPS6KA3 MAPK1	2.39e-05	4	70	2	12529330
Pubmed	ERK1/2 regulates ANG II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1.	RPS6KA3 MAPK1	2.39e-05	4	70	2	16723511
Pubmed	Suppression of epithelial differentiation by Foxi3 is essential for molar crown patterning.	IRX5 IRX3 IRX2	3.05e-05	30	70	3	26450968
Pubmed	Sox11 gene disruption causes congenital anomalies of the kidney and urinary tract (CAKUT).	IRX3 IRX1 IRX2	3.37e-05	31	70	3	29459093
Pubmed	Tangential Intrahypothalamic Migration of the Mouse Ventral Premamillary Nucleus and Fgf8 Signaling.	IRX5 IRX3 IRX1	3.37e-05	31	70	3	34095148
Pubmed	Irx3 and Irx5 in Ins2-Cre+ cells regulate hypothalamic postnatal neurogenesis and leptin response.	IRX5 IRX3	3.98e-05	5	70	2	33859429
Pubmed	Identification of a domain on the beta-subunit of the rod cGMP-gated cation channel that mediates inhibition by calcium-calmodulin.	MAPK1 CNGB1	3.98e-05	5	70	2	9535905
Pubmed	Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease.	RPS6KA3 MAPK1	3.98e-05	5	70	2	11404397
Pubmed	Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo.	RPS6KA3 MAPK1	3.98e-05	5	70	2	9915826
Pubmed	Mast cells are crucial for early inflammation, migration of Langerhans cells, and CTL responses following topical application of TLR7 ligand in mice.	TLR7 KIT	3.98e-05	5	70	2	17446350
Pubmed	pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167.	RPS6KA3 MAPK1	3.98e-05	5	70	2	9528769
Pubmed	The p53 protein is a novel substrate of ribosomal S6 kinase 2 and a critical intermediary for ribosomal S6 kinase 2 and histone H3 interaction.	RPS6KA3 MAPK1	3.98e-05	5	70	2	15867353
Pubmed	Expression pattern of Irx1 and Irx2 during mouse digit development.	IRX1 IRX2	3.98e-05	5	70	2	11472848
Pubmed	Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis.	IRX1 IRX2 IRX4	4.08e-05	33	70	3	16870172
Pubmed	The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.	IRX5 ALYREF IRX3 IRX1 IRX2	4.30e-05	191	70	5	24146773
Pubmed	Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.	RPS6KA3 MAPK1	5.96e-05	6	70	2	12832467
Pubmed	Humanized mice for investigating sustained Plasmodium vivax blood-stage infections and transmission.	C5 KIT	5.96e-05	6	70	2	35840625
Pubmed	Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529.	RPS6KA3 MAPK1	5.96e-05	6	70	2	18156174
Pubmed	Functional Analysis of KIT Gene Structural Mutations Causing the Porcine Dominant White Phenotype Using Genome Edited Mouse Models.	MAPK1 KIT	5.96e-05	6	70	2	32194624
Pubmed	A genome-wide scan maps a novel high myopia locus to 5p15.	IRX1 IRX2	5.96e-05	6	70	2	18421076
Pubmed	Dynamic expression patterns of Irx3 and Irx5 during germline nest breakdown and primordial follicle formation promote follicle survival in mouse ovaries.	IRX5 IRX3	5.96e-05	6	70	2	30071018
Pubmed	The MAP kinase ERK5 binds to and phosphorylates p90 RSK.	RPS6KA3 MAPK1	5.96e-05	6	70	2	16626623
Pubmed	Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases.	RPS6KA3 MAPK1	5.96e-05	6	70	2	8939914
Pubmed	Irx1 and Irx2 expression in early lung development.	IRX1 IRX2	5.96e-05	6	70	2	11472847
Pubmed	HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2.	IRX3 IRX1 IRX2	7.31e-05	40	70	3	23362348
Pubmed	c-Kit mutants require hypoxia-inducible factor 1alpha to transform melanocytes.	MAPK1 KIT	8.33e-05	7	70	2	19802003
Pubmed	C1q governs deposition of circulating immune complexes and leukocyte Fcgamma receptors mediate subsequent neutrophil recruitment.	C5 KIT	8.33e-05	7	70	2	15466618
Pubmed	Ataxia telangiectasia mutated proteins, MAPKs, and RSK2 are involved in the phosphorylation of STAT3.	RPS6KA3 MAPK1	8.33e-05	7	70	2	12562765
Pubmed	Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry.	RPS6KA3 MAPK1	8.33e-05	7	70	2	11181841
Pubmed	Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions.	RPS6KA3 MAPK1	8.33e-05	7	70	2	11157753
Pubmed	A ERK/RSK-mediated negative feedback loop regulates M-CSF-evoked PI3K/AKT activation in macrophages.	RPS6KA3 MAPK1	8.33e-05	7	70	2	29046360
Pubmed	Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice.	IRF8 TLR7	8.33e-05	7	70	2	34376664
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXE1 IRX5 MKX IRF8 IRX3 IRX6 IRX1 IRX2 IRX4	8.47e-05	908	70	9	19274049
Pubmed	Steroidogenic factor 1 (SF-1; Nr5a1) regulates the formation of the ovarian reserve.	IRX5 IRX3 KIT	9.75e-05	44	70	3	37494420
Pubmed	Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation.	IRF8 KIT	1.11e-04	8	70	2	27412700
Interaction	IRX1 interactions	MKX IRX6 IRX1	5.51e-07	6	62	3	int:IRX1
Interaction	IRX6 interactions	MKX IRX6 IRX1	1.23e-05	15	62	3	int:IRX6
Interaction	MKX interactions	MKX IRX6 IRX1	2.19e-05	18	62	3	int:MKX
Interaction	DUX4L8 interactions	UBR3 KDM4A	5.57e-05	4	62	2	int:DUX4L8
Cytoband	16q12.2	IRX5 IRX3 IRX6	8.24e-06	26	69	3	16q12.2
Cytoband	5p15.3	IRX1 IRX4	9.94e-05	10	69	2	5p15.3
Cytoband	Ensembl 112 genes in cytogenetic band chr5p15	SLC6A18 IRX1 IRX2 IRX4	2.61e-04	204	69	4	chr5p15
Cytoband	9q21.32	SPATA31D4 SPATA31D3	3.74e-04	19	69	2	9q21.32
Cytoband	Ensembl 112 genes in cytogenetic band chr16q12	IRX5 IRX3 IRX6	5.16e-04	103	69	3	chr16q12
Cytoband	5p15.33	SLC6A18 IRX2	1.07e-03	32	69	2	5p15.33
GeneFamily	TALE class homeoboxes and pseudogenes	IRX5 MKX IRX3 IRX6 IRX1 IRX2 IRX4	3.73e-13	26	48	7	526
Coexpression	GSE32986_GMCSF_VS_GMCSF_AND_CURDLAN_HIGHDOSE_STIM_DC_DN	AHI1 ITSN1 ARMCX6 MAPK1 MADD DNAH1	8.97e-06	198	64	6	M8624
CoexpressionAtlas	breast	IRX5 IRX3 IRX1 ALDH3B2 IRX2 KIT	2.00e-06	124	64	6	breast
ToppCell	P15-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 C5 CPM IRX1 IRX2 DNASE2	7.76e-09	170	68	7	6c0619cbe2f01a6de18da0a137f92bda0cbdf075
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 C5 CPM IRX1 ALDH3B2 IRX2	1.34e-08	184	68	7	fa4915b0498f3069fd5ef497286445528f75187e
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 C5 IRX6 CPM IRX1 IRX2	1.50e-08	187	68	7	db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCell	PCW_05-06-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	IRX5 FAM111A IRX3 IRX6 CPM IRX1 IRX2	1.61e-08	189	68	7	c8b8f860aaf6c73863cd79941db6b469c830ef06
ToppCell	wk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_late\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 C5 IRX6 CPM IRX1 IRX2	2.07e-08	196	68	7	75e9e430a4f55ef10f2e3132afa690fc8bfaff83
ToppCell	wk_15-18-Epithelial-Distal_epithelial_progenitor\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 C5 IRX6 CPM IRX1 IRX2	2.07e-08	196	68	7	00bef0e47739932fd1da109cd607de0789d14ca5
ToppCell	Control_saline-Epithelial_alveolar-AT_2\|Control_saline / Treatment groups by lineage, cell group, cell type	EPHX1 IRX5 IRX3 C5 CPM IRX1 IRX2	2.14e-08	197	68	7	b8f62fcd6eb8f47b3cc41f616126f82c68a36e87
ToppCell	Control_saline-Epithelial_alveolar-AT_2-AT2\|Control_saline / Treatment groups by lineage, cell group, cell type	EPHX1 IRX5 IRX3 C5 CPM IRX1 IRX2	2.14e-08	197	68	7	f870a26f322668781e3d2832c5d9ef2c7c91011f
ToppCell	Control_saline-Epithelial_alveolar-AT_1-2_Progenitor-AT2_Progenitor\|Control_saline / Treatment groups by lineage, cell group, cell type	EPHX1 IRX5 IRX3 C5 CPM IRX1 IRX2	2.22e-08	198	68	7	030ef63e2fc5b3d601c1a48462d797aa19ee7ff5
ToppCell	Control_saline-Epithelial_alveolar-AT_1-2_Progenitor-Progenitor_AT1-AT2\|Control_saline / Treatment groups by lineage, cell group, cell type	EPHX1 IRX5 IRX3 C5 CPM IRX1 IRX2	2.22e-08	198	68	7	827aa9d919bf6d670961e5501e17d351676127e3
ToppCell	Control_saline-Epithelial_alveolar-AT_1-2_Progenitor\|Control_saline / Treatment groups by lineage, cell group, cell type	EPHX1 IRX5 IRX3 C5 CPM IRX1 IRX2	2.22e-08	198	68	7	cd8a26de6c1cb9c42635146bb7220dd1b41ee97d
ToppCell	Control_saline-Epithelial_alveolar\|Control_saline / Treatment groups by lineage, cell group, cell type	EPHX1 IRX5 IRX3 C5 CPM IRX1 IRX2	2.22e-08	198	68	7	532b7ef4ad46fe35ad2c6bdf89f70a17f1a2e2e2
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ADAM18 IRX6 IRX1 IRX2 IRX4	9.42e-08	73	68	5	562f2264476e5402eda1cf0c8b28c3d325cbc6f1
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ADAM18 IRX6 IRX1 IRX2 IRX4	9.42e-08	73	68	5	6b1971d4a50a1f644f70b3e08b9a825434cc6f0c
ToppCell	Thalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a7\|Thalamus / BrainAtlas - Mouse McCarroll V32	IRX5 GUCY2C IRX1 IRX2 IRX4 DNAH1	1.68e-07	160	68	6	7d34159363d274019e14549d1186c629ce990691
ToppCell	Thalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a7-Tac2\|Thalamus / BrainAtlas - Mouse McCarroll V32	IRX5 GUCY2C IRX1 IRX2 IRX4 DNAH1	1.68e-07	160	68	6	fe5fb0e7a79862f63529721f0a82f4f6d231d3ca
ToppCell	Thalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)\|Thalamus / BrainAtlas - Mouse McCarroll V32	AHI1 IRX5 IRX3 IRX1 IRX2 DNAH1	1.74e-07	161	68	6	0605134a342d74ae81f33700d6ddfcd6e03aeb7b
ToppCell	P28-Epithelial-epithelial_progenitor_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 C5 CPM IRX1 IRX2	2.24e-07	168	68	6	03c95ad3684caec7a6d581006b237cc5fa230685
ToppCell	P28-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 C5 CPM IRX1 IRX2	2.40e-07	170	68	6	d0ed3a8a7ad96c05641ec409b0a69c4fb094893c
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_A\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	CLN8 ECD IRF8 PCSK7 ITK	2.55e-07	89	68	5	d8832dbe69d3490ceaa05ccc99d7c81707803925
ToppCell	P03-Epithelial-epithelial_progenitor_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 C5 IRX1 IRX2 DNASE2	2.75e-07	174	68	6	23c7fdfc73170cfc5cdee5bb7fbee0c8bbbbca07
ToppCell	E17.5-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 C5 CPM IRX1 IRX2	2.75e-07	174	68	6	68914ec843f58ecff3e6412544a341daf8a01cac
ToppCell	P28-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 C5 CPM IRX1 IRX2	2.85e-07	175	68	6	8a4ed775ff973123dbcfe9c809959d11a62450c9
ToppCell	P03-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 C5 IRX1 IRX2 DNASE2	2.85e-07	175	68	6	a6d9ca35d3c4b4e3889d0a69b514f63ae630da6b
ToppCell	P15-Epithelial\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 C5 IRX1 IRX2 DNASE2	3.25e-07	179	68	6	869d3d203e2cb88636e2f0c4476c72571ae3b5ca
ToppCell	P03-Epithelial-alveolar_epithelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 C5 IRX1 IRX2 DNASE2	3.47e-07	181	68	6	c3dbf8850d3812fbb770798f4cf38908db8bb92b
ToppCell	P15-Epithelial-alveolar_epithelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 C5 IRX1 IRX2 DNASE2	3.47e-07	181	68	6	7033be0ba90556f7e5f7c0d4a9f7644afcb22c9b
ToppCell	P03-Epithelial\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 C5 IRX1 IRX2 DNASE2	3.47e-07	181	68	6	de0466072f5b2ab8db3d9bab31e3205d1ff7cfb7
ToppCell	Control-Epithelial_alveolar-AT_2-AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPHX1 IRX5 IRX3 C5 IRX1 IRX2	3.59e-07	182	68	6	e97681a4102f3095d5d9e90ad70f1dc46e90983a
ToppCell	P28-Epithelial\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 C5 CPM IRX1 IRX2	3.82e-07	184	68	6	05811d13bd8a602095a3fcf5e55345edadc7b8bf
ToppCell	Control-Epithelial_alveolar-AT_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPHX1 IRX5 IRX3 C5 IRX1 IRX2	3.82e-07	184	68	6	51e129b3fcc2df083eda05a3afe3717218b1e52b
ToppCell	Control-Epithelial_alveolar-AT_2-AT2_Progenitor\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPHX1 IRX5 IRX3 C5 IRX1 IRX2	3.95e-07	185	68	6	8ca1374501eca01d8468130b74d50abfd4329fbe
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 IRX6 CPM IRX1 IRX2	4.07e-07	186	68	6	bb0bfe9a015151be08a6ffc5d82896d0556d76de
ToppCell	E17.5-Epithelial-alveolar_epithelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 CPM IRX1 IRX2 DNASE2	4.07e-07	186	68	6	a7a2ef8392a045a62fa4d0983577711d5d397dc4
ToppCell	E17.5-Epithelial\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 CPM IRX1 IRX2 DNASE2	4.20e-07	187	68	6	fdabe716ce67f2eede90548198cbe20bbf693570
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 C5 CPM IRX1 IRX2	4.47e-07	189	68	6	5d9da836ce4308b8458bb3be3871a0aca734b6cd
ToppCell	E17.5-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 CPM IRX1 IRX2 DNASE2	4.61e-07	190	68	6	8e9ba1f1af520564a1a7dfa9ef74ef5f0d0bf0d5
ToppCell	droplet-Lung-nan-18m-Epithelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IRX5 IRX3 CPM IRX1 IRX2 DNAH1	4.61e-07	190	68	6	b057bea6e55cef872290893b6e439bbcdcee2f2e
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor-epi-stalk_early\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	IRX5 ALYREF IRX3 CPM IRX1 IRX2	4.61e-07	190	68	6	9f5f65869dad9a43ac94f81f9a19c72ffe5adc3c
ToppCell	E17.5-Epithelial-epithelial_progenitor_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 CPM IRX1 IRX2 DNASE2	4.76e-07	191	68	6	68b717fce7d9349ef56255ee0c5e57fc67e50fd8
ToppCell	wk_20-22-Epithelial-Distal_epithelial_progenitor\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	IRX5 C5 IRX6 CPM IRX1 IRX2	4.91e-07	192	68	6	fa2420d6117d4800f60ef6a24bcf8bf54593cd1f
ToppCell	wk_20-22-Epithelial-Distal_epithelial_progenitor-epi-tip_late\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	IRX5 C5 IRX6 CPM IRX1 IRX2	4.91e-07	192	68	6	87b60014202633a4f6d19b09a5dd9276c2edecfb
ToppCell	11.5-Airway-Epithelial-Bud_tip_progenitor\|Airway / Age, Tissue, Lineage and Cell class	IRX5 IRX3 IRX6 CPM IRX1 IRX2	5.06e-07	193	68	6	f0a07bb221a497a9f7cc706045d5205269be4515
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 CPM IRX1 IRX2 CNGB1	5.21e-07	194	68	6	c5ef4ff73b4e51530656002e3a2fb7264cdf533d
ToppCell	PCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 IRX6 CPM IRX1 IRX2	5.21e-07	194	68	6	c011cd59bb4ca4134331cba0f5d73bdbd7011d64
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 IRX6 CPM IRX1 IRX2	5.21e-07	194	68	6	c47fc3f716ab091a39c20d7639ac783029589ee5
ToppCell	PCW_10-12-Epithelial-Epithelial_airway-epi_intermediate_(1)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 C5 CPM IRX1 IRX2	5.37e-07	195	68	6	d67a2b489c29bfd575751c13d2a5b1efdec5240a
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 IRX6 CPM IRX1 IRX2	5.37e-07	195	68	6	98dd3b7d5ef587825dac052dea4d4ff883f6d4d6
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 IRX6 CPM IRX1 IRX2	5.37e-07	195	68	6	f08e41706680881ebd0afcd08a02f8ac0089f04e
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 IRX6 CPM IRX1 IRX2	5.37e-07	195	68	6	ce1ba5911e8a6ddb07434acc37147c38e94245ff
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 IRX6 CPM IRX1 IRX2	5.37e-07	195	68	6	62d369a8af2b76a2553bc8ff9cb89a133b060123
ToppCell	wk_15-18-Epithelial-Distal_epithelial-type_II_pneumocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 C5 CPM IRX1 IRX2	5.37e-07	195	68	6	0e3aac1b1a1fd483f5fb9a394eb90c0e1ce63542
ToppCell	11.5-Distal-Epithelial-Bud_tip_progenitor\|Distal / Age, Tissue, Lineage and Cell class	IRX5 IRX3 IRX6 CPM IRX1 IRX2	5.54e-07	196	68	6	42eae265e2f2082983d8c2607c7f6a53a526d124
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 IRX6 CPM IRX1 IRX2	5.54e-07	196	68	6	0a34a0009f479384f1994c6f977f942699a132c8
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 IRX6 CPM IRX1 IRX2	5.70e-07	197	68	6	22b26bac3a99b20c73bfa6e6f81026d064eaa9e8
ToppCell	Control_saline-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control_saline / Treatment groups by lineage, cell group, cell type	EPHX1 AHI1 IRX3 C5 CPM IRX1	5.70e-07	197	68	6	44a59dfb889577b3160a5b13ada1276771a00241
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2-AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	EPHX1 IRX5 IRX3 C5 IRX1 IRX2	5.70e-07	197	68	6	ad6f047d003c08413264f39a30ba0f7639a257cd
ToppCell	15-Distal-Epithelial-Bud_tip_progenitor\|Distal / Age, Tissue, Lineage and Cell class	IRX5 IRX3 IRX6 CPM IRX1 IRX2	5.70e-07	197	68	6	532635810f17199fa6c14b986f663884d5d05ab5
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 IRX6 CPM IRX1 IRX2	5.70e-07	197	68	6	6852a8ec1397811bbdd1fc625c52ed4fa75a931e
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	EPHX1 IRX5 IRX3 C5 IRX1 IRX2	5.70e-07	197	68	6	1638959d7aecb9fc5285eb7e4a3103ca437989e2
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 IRX6 CPM IRX1 IRX2	5.70e-07	197	68	6	2f91b3870a7058168093a143110954c07588cfe9
ToppCell	LPS-IL1RA-Epithelial_alveolar-Mes-Like-AT2_Progenitor\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KCNU1 IRX3 C5 IRX6 IRX1	5.83e-07	105	68	5	9ed5482b445eacf16d5769f79438098b0e71123a
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-2_Progenitor-Progenitor_AT1-AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	EPHX1 IRX5 IRX3 C5 IRX1 IRX2	5.87e-07	198	68	6	50852713c017217c79777c95857097103bcf2fbe
ToppCell	LPS_only-Epithelial_alveolar-AT_2\|LPS_only / Treatment groups by lineage, cell group, cell type	EPHX1 IRX5 IRX3 C5 IRX1 IRX2	5.87e-07	198	68	6	d087e738d69ca9853553fde46d4e7a8906439d32
ToppCell	wk_15-18-Epithelial-Airway_epithelial_progenitor-epi-stalk_late\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 C5 CPM IRX1 IRX2	5.87e-07	198	68	6	1851b7f4198b42c21c934e2fbda39dbd65e2625c
ToppCell	wk_15-18-Epithelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 C5 CPM IRX1 IRX2	5.87e-07	198	68	6	12bbe77c3d68bf1e545949dbb1eb49ed3641de3d
ToppCell	LPS_only-Epithelial_alveolar-AT_2-AT2\|LPS_only / Treatment groups by lineage, cell group, cell type	EPHX1 IRX5 IRX3 C5 IRX1 IRX2	5.87e-07	198	68	6	6b6572deeca98ccb015f2aa3c5ce27de44445f74
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2-AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	EPHX1 IRX5 IRX3 C5 IRX1 IRX2	5.87e-07	198	68	6	d12f37527399038a8f030b45b176bda5c7c8a7ad
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	EPHX1 IRX5 IRX3 C5 IRX1 IRX2	5.87e-07	198	68	6	c4e7512f0e1d115f2be8acae6048eda8b6b640b2
ToppCell	LPS_anti-TNF-Epithelial_alveolar\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	EPHX1 IRX5 IRX3 C5 IRX1 IRX2	5.87e-07	198	68	6	53e9ed1b19cb26be58da0f37057caca0cdfaabeb
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2-AT2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	EPHX1 IRX5 IRX3 C5 IRX1 IRX2	5.87e-07	198	68	6	d499dced27b0c0e21acfda2c20fa5c114f605085
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-2_Progenitor\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	EPHX1 IRX5 IRX3 C5 IRX1 IRX2	5.87e-07	198	68	6	f006d68e6c51923be7772eea118546a5762e8a5e
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	AHI1 IRX5 IRX3 C5 IRX1 IRX2	5.87e-07	198	68	6	aa80315395cb5dffc25927c8a77cd2037aea8772
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor-epi-stalk_intermediate\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 C5 CPM IRX1 IRX2	6.05e-07	199	68	6	debdd7dba774d9ccff7effc3f4c132393d203dfa
ToppCell	LPS_only-Epithelial_alveolar-AT_1-2_Progenitor-Progenitor_AT1-AT2\|LPS_only / Treatment groups by lineage, cell group, cell type	EPHX1 IRX5 IRX3 C5 IRX1 IRX2	6.05e-07	199	68	6	0447f8f53389fe7c6ddc04a97d86e74122ea16f4
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-2_Progenitor-Progenitor_AT1-AT2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	EPHX1 IRX5 IRX3 C5 IRX1 IRX2	6.05e-07	199	68	6	329c381404d4972871142dd7f7ee78fbcc365aa1
ToppCell	LPS_only-Epithelial_alveolar-AT_2-AT1-AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IRX5 IRX3 C5 IRX1 IRX2	8.04e-07	112	68	5	456278fb92dd41820fde8cf27c68fec45e15f972
ToppCell	Substantia_nigra\|World / BrainAtlas - Mouse McCarroll V32	IRX5 GUCY2C IRX3 IRX1 IRX2	9.16e-07	115	68	5	18174b8d57d444fab1e9d2b13d22939c83c958e0
ToppCell	P15-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 C5 IRX1 IRX2	3.07e-06	147	68	5	aba44c7057096483c4293a7ebcf8ccc8baed0231
ToppCell	wk_20-22-Epithelial-Airway_epithelial_progenitor\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	C5 IRX6 CPM IRX1 IRX2	5.56e-06	166	68	5	fcd0bd70b553789092249806ace324b77bd10481
ToppCell	wk_20-22-Epithelial-Airway_epithelial_progenitor-epi-stalk_late\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	C5 IRX6 CPM IRX1 IRX2	5.56e-06	166	68	5	b60954e5625743657d0fd9264b738b46e72fd8a6
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	IRX3 IRX6 CPM IRX1 IRX2	5.73e-06	167	68	5	25af48c640e67848594f5902867ba325fc105da4
ToppCell	P07-Epithelial-epithelial_progenitor_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 C5 IRX1 IRX2	6.07e-06	169	68	5	ec23caecbb0d969307e33e9df8499ddcd1420305
ToppCell	P07-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 C5 IRX1 IRX2	6.07e-06	169	68	5	53e863de064d44e1d36e21fb3dbba37ae020f6e9
ToppCell	P07-Epithelial-epithelial_progenitor_cell-epi_progenitor\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 C5 IRX1 IRX2	6.07e-06	169	68	5	1a47a4892a5e6a69555f5332308503526e5422a7
ToppCell	E12.5-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 C5 IRX1 IRX2	6.42e-06	171	68	5	a4d6b0f57eead11b01153688b06b2a45a3b488f2
ToppCell	P07-Epithelial\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 C5 IRX1 IRX2	6.80e-06	173	68	5	8b10087a917b825809d35a2b2b349c73a2782472
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-AT2_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IRX5 IRX3 C5 IRX1 IRX2	6.99e-06	174	68	5	d0e3d15731de6c19c232e3aa492c39d8151cf4ed
ToppCell	P07-Epithelial-alveolar_epithelial_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IRX5 IRX3 C5 IRX1 IRX2	6.99e-06	174	68	5	2739de68e0266054694f99807cfb1f07b6bbb371
ToppCell	droplet-Liver-Hepatocytes-21m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IRX5 ADAM18 IRX3 IRX1 IRX2	7.81e-06	178	68	5	4289e435d465b7a1490d13bf05278f4ed77d69cd
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IRX5 IRX3 C5 IRX1 IRX2	8.02e-06	179	68	5	7db6b97a1c4c7a163d5da4351ba36ac1785d9d7b
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IRX5 IRX3 C5 IRX1 IRX2	8.24e-06	180	68	5	b798a3fa2dd15b68aa4267f665559527043dcc07
ToppCell	LPS_only-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IRX5 IRX3 C5 IRX1 IRX2	8.46e-06	181	68	5	0513b9e6673ff7bf8e72ba123ca3794b65d10170
ToppCell	Control-Epithelial_alveolar-AT_1-AT1-AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IRX5 IRX3 C5 IRX1 IRX2	8.69e-06	182	68	5	a95956ce4adccb34cc0c47ebfa1878ce4617904e
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-AT1-AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPHX1 IRX5 IRX3 IRX1 IRX2	8.69e-06	182	68	5	cc79e0cc21e2fdc4ef77f052818d27b9f707aec1
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IRX5 IRX3 C5 IRX1 IRX2	8.69e-06	182	68	5	1e2149b222a3e9f64841aed45288a6f29394e7b0
ToppCell	LPS_only-Epithelial_alveolar-AT_2-AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IRX5 IRX3 C5 IRX1 IRX2	8.69e-06	182	68	5	d1a1feef318062f25493355d7beee8e5fb0e4206
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IRX5 IRX3 C5 IRX1 IRX2	8.69e-06	182	68	5	17ed11a7ea366dd3106400511d5e628d3f1a9c3e
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IRX5 IRX3 C5 IRX1 IRX2	8.93e-06	183	68	5	5f2db95d44b7de68779de098892892af540fd431
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	IRX5 IRX3 CPM IRX1 IRX2	8.93e-06	183	68	5	c5b10571599dc26476170b54b53f09c23e6b3117
Disease	Lung diseases	IRX5 IRX3 IRX1 IRX2 KIT	6.00e-07	78	61	5	C0024115
Disease	triacylglycerol 48:4 measurement	DSCAM SFMBT2	3.76e-04	14	61	2	EFO_0010407
Disease	alcohol use disorder (implicated_via_orthology)	KCNU1 ALYREF RYR2 MADD	7.19e-04	195	61	4	DOID:1574 (implicated_via_orthology)
Disease	Retinitis Pigmentosa	AHI1 IRX5 CNGB1	1.32e-03	104	61	3	C0035334
Disease	Malignant mesothelioma	EPHX1 KIT RYR2	1.51e-03	109	61	3	C0345967
Disease	cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement	PCSK7 MADD CES2 DNAH1	1.62e-03	243	61	4	EFO_0004612, EFO_0020944

Protein segments in the cluster

Peptide	Gene	Start	Entry
QKLPAWIKNGLYLHN	AMIGO1	206	Q86WK6
QPYDFKQLKSRLPEW	AHI1	406	Q8N157
NYSHIWQKDQPYKVP	ADAM18	156	Q9Y3Q7
KLKEIHYPPYTDWNQ	ALDH3B2	356	P48448
VPYIWQNQPFNLKYK	ECD	51	O95905
KQRPFPYEHKNTWSA	ARMCX6	101	Q7L4S7
NHKKQDPDVPFWRFL	EDC4	356	Q6P2E9
YELRQKKWSHIPPEN	GUCY2C	461	P25092
TLKAWLQEHRKNPYP	IRX4	156	P78413
WLNEHRKNPYPTKGE	IRX5	131	P78411
LKAWLNEHRKNPYPT	IRX6	161	P78412
RNYLLSLPHKNKVPW	MAPK1	261	P28482
IGDKPKWYAHQLQPI	MADD	576	Q8WXG6
KHRYQFWDTQPVPKL	NMT2	116	O60551
PKPEHQQWIYMNRTF	KIT	341	P10721
KHQPYKLGRQWPELL	FRMD8	91	Q9BZ67
SLHWYQQKPDQSPKL	IGKV6-21	51	A0A0C4DH24
DWNKLYRREIHPPFK	RPS6KA3	331	P51812
HNYPWNKLPANVRQS	FAM91A1	11	Q658Y4
PFRKVDYTKNINPNW	DCLK2	151	Q8N568
NDPKYPQQWHLNNRR	PCSK7	146	Q16549
FRIPWKHAGKQDYNQ	IRF8	36	Q02556
KQWLYKHRDNPYPTK	MKX	86	Q8IYA7
SLHWYQQKPDQSPKL	IGKV6D-21	51	A0A0A0MT36
NWNIYKLLAHQKPPK	PFKL	381	P17858
YEFQHQPSWLKNIRP	CES2	436	O00748
ELERKYWKNLTFNPP	KDM4A	116	O75164
NSNKPREWIRHFFPK	GBP7	216	Q8N8V2
QSHNKVYLPKIPSWN	KCNU1	451	A8MYU2
AWLNEHRKNPYPTKG	IRX2	131	Q9BZI1
NLNPARKYFPQWKAP	PGA3	46	P0DJD8
PYKKPFEQRINSWEN	DNAH1	1211	Q9P2D7
FDWKKQVEILNRYPH	EPHX1	101	P07099
PALWKAFQPLVKNYQ	DNASE2	331	O00115
KYPREEKLPSFWNNN	CPM	286	P14384
HYKREKPLQPVVWSQ	GBGT1	51	Q8N5D6
PYNNLKHKFPWLSEA	CDK10	281	Q15131
KQRHKPWYEEVFVNQ	FAM111A	586	Q96PZ2
NPPIYRFWKDNLQHK	C5	1221	P01031
LYPWRAKKDNHLNFN	ITSN1	921	Q15811
KPNNYLLAWHTPFNE	ADPRHL1	111	Q8NDY3
KWKPLNNPRNRDLFF	C2orf66	46	Q6UXQ4
FVDYNRAKWLKEPNP	RYR2	3376	Q92736
HNLNYWQLLRKEKVP	CROT	131	Q9UKG9
TLKAWLNEHRKNPYP	IRX3	141	P78415
RNNNSLVPKYHPNFW	ITK	111	Q08881
KWYKNSNLLPFNHRQ	DSCAM	536	O60469
AWKRFQHQVPLYLKG	TAS2R40	306	P59535
RFPFYRDNPKKWQNS	FOXE1	86	O00358
TLKAWLNEHRKNPYP	IRX1	141	P78414
KGKLEWQHIHQQPPY	SPATA31D4	471	Q6ZUB0
LKNWAANRPPNTYVK	SYT14P1	76	Q58G82
KAWNPKYELFPSRQE	SLC6A18	546	Q96N87
NPYWTHKKTQQLLNP	CLN8	246	Q9UBY8
YKWHKEPLQQCNPDG	CHST2	76	Q9Y4C5
PENWKENPQYKRPKH	CLCA4	81	Q14CN2
QPYLWARLDRKPNKQ	C12orf29	71	Q8N999
HRPWKKYQFPQSIDP	CNGB1	636	Q14028
NQLPVWIPTRHLKFY	ERVK-25	841	P63136
KGKLEWQHIHQQPPY	SPATA31D3	471	P0C874
KLYQFRHPVRLFWPK	RIPPLY2	71	Q5TAB7
PHWNFQEETLKAKYR	SFMBT2	591	Q5VUG0
VKWRQLEHKGPYFAP	TOP1MT	51	Q969P6
EIKNLFTKTHPQWYP	TECR	31	Q9NZ01
SLQHVPPRWFKNINK	TLR7	301	Q9NYK1
ELQPWKHYIPVKSNL	POGLUT2	401	Q6UW63
KWKLPHLLQLPENYN	UBR3	1741	Q6ZT12
NQLPVWIPTRHLKFY	ERVK-19	846	Q9WJR5
QWFQNHLDPQKKRYS	TMA16	56	Q96EY4
PYSRPKQLPDKWQHD	ALYREF	76	Q86V81
PRYHLQPKNFNWTGE	TTLL13	691	A6NNM8