Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	S100_CABP	FLG S100A16	4.20e-03	27	67	2	PS00303
Domain	S_100	FLG S100A16	4.20e-03	27	67	2	PF01023
Domain	S100_Ca-bd_sub	FLG S100A16	4.51e-03	28	67	2	IPR013787
Domain	S100/CaBP-9k_CS	FLG S100A16	4.51e-03	28	67	2	IPR001751
Domain	S_100	FLG S100A16	4.51e-03	28	67	2	SM01394
Domain	BRCT_dom	DBF4 SMARCC1	4.51e-03	28	67	2	IPR001357
Domain	Myb_DNA-binding	SMARCC1 TTF1	6.99e-03	35	67	2	PF00249
Pubmed	VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN.	GPSM2 CDH5	3.66e-06	2	67	2	28712573
Pubmed	ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin.	ADAM10 CDH5	3.66e-06	2	67	2	18420943
Pubmed	Interaction of calcium binding protein S100A16 with myosin-9 promotes cytoskeleton reorganization in renal tubulointerstitial fibrosis.	MYH9 S100A16	3.66e-06	2	67	2	32094322
Pubmed	A genome-wide association study in Caucasian women points out a putative role of the STXBP5L gene in facial photoaging.	STXBP5L POLQ	1.10e-05	3	67	2	23223146
Pubmed	Nonmuscle myosin II isoforms interact with sodium channel alpha subunits.	MYH9 SCN2A	1.10e-05	3	67	2	29956586
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	BPTF EIF2D PAXBP1 S100A16 RBBP6 DBF4 ZNF638 SMARCC1 PRDM2	1.73e-05	774	67	9	15302935
Pubmed	Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome.	WHRN GPSM2	2.19e-05	4	67	2	28387217
Pubmed	ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration.	ADAM10 CDH5	2.19e-05	4	67	2	28600292
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	BPTF PAXBP1 RBBP6 FRG1 ZNF638 SMARCC1 AMZ2	3.36e-05	469	67	7	27634302
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	BPTF MYH9 PAXBP1 TCERG1 RBBP6 FRG1 ZNF638 SMARCC1 UBN2 TTF1 PRDM2	3.44e-05	1294	67	11	30804502
Pubmed	CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility.	CEP350 AKAP3	3.64e-05	5	67	2	27965440
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	FLG BPTF MYH9 PAXBP1 UPF2 TCERG1 RBBP6 FRG1 ZNF638 SMARCC1	4.04e-05	1082	67	10	38697112
Pubmed	Secreted frizzled related proteins modulate pathfinding and fasciculation of mouse retina ganglion cell axons by direct and indirect mechanisms.	SFRP2 ADAM10	5.46e-05	6	67	2	25788689
Pubmed	RABL2 interacts with the intraflagellar transport-B complex and CEP19 and participates in ciliary assembly.	CEP350 IFT81	7.63e-05	7	67	2	28428259
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	BPTF CCDC59 UPF2 TCERG1 RBBP6 FRG1 AGGF1 TTF1	1.04e-04	759	67	8	35915203
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	BPTF MYH9 TCERG1 RBBP6 POLQ	1.24e-04	250	67	5	33536335
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	BPTF PAXBP1 RBBP6 ZNF638 SMARCC1	1.26e-04	251	67	5	31076518
Pubmed	GPSM2-GNAI Specifies the Tallest Stereocilia and Defines Hair Bundle Row Identity.	WHRN GPSM2	1.30e-04	9	67	2	30827920
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	TCERG1 ZNF638 SECISBP2 TMEM131 CRYBG3	1.57e-04	263	67	5	34702444
Pubmed	Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis.	SYCP2 TEX15	1.63e-04	10	67	2	18283110
Pubmed	Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K and AKT and disrupts vascular integrity by activating VE-cadherin.	AGGF1 CDH5	1.63e-04	10	67	2	27522498
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	BPTF MYH9 TCERG1 ZNF638 SMARCC1	1.80e-04	271	67	5	32433965
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	BPTF MYH9 TCERG1 RBBP6 ZNF638	2.20e-04	283	67	5	30585729
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	BPTF CCDC59 KIF27 TCERG1 IFT81 AGGF1 SMARCC1 TTF1	2.38e-04	857	67	8	25609649
Pubmed	The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.	CEP350 IFT81	2.38e-04	12	67	2	28625565
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	CEP350 RNASEH2B CCDC59 FRG1 IFT81 ZNF638 UBN2	2.42e-04	645	67	7	25281560
Pubmed	Sfrp1 and Sfrp2 are required for normal male sexual development in mice.	SFRP2 RXFP2	2.81e-04	13	67	2	19100252
Pubmed	Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling.	MYH9 CDH5	3.28e-04	14	67	2	21396893
Pubmed	VGLL4 plays a critical role in heart valve development and homeostasis.	CCN1 CDH5	3.28e-04	14	67	2	30789911
Pubmed	Genetic Hearing Loss Overview	WHRN MYH9 GPSM2	3.41e-04	70	67	3	20301607
Pubmed	RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells.	WHRN GPSM2	3.78e-04	15	67	2	36260679
Pubmed	Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.	EIF2D TGS1	4.31e-04	16	67	2	12097419
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	MYH9 NRBP2 PAXBP1 UPF2 RBBP6 FRG1 ZNF638	4.43e-04	713	67	7	29802200
Pubmed	SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis.	SFRP2 ADAM10	4.88e-04	17	67	2	21478884
Pubmed	Screening E3 substrates using a live phage display library.	RBBP6 PRDM2	4.88e-04	17	67	2	24124579
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	BPTF UPF2 RBBP6 FRG1 ZNF638	5.17e-04	341	67	5	32971831
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	CEP350 VPS13C ZNF638 AKAP3 SECISBP2 TMEM131 TGS1	5.22e-04	733	67	7	34672954
Pubmed	Chloride intracellular channel 4 is required for maturation of the cerebral collateral circulation.	ADAM10 CDH5	5.48e-04	18	67	2	26276819
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	RNASEH2B WHRN MYH9 PIK3CB SECISBP2 SCIMP WDR37 AMZ2 POLR3F	6.10e-04	1242	67	9	30973865
Pubmed	Cerebrovascular defects in Foxc1 mutants correlate with aberrant WNT and VEGF-A pathways downstream of retinoic acid from the meninges.	SFRP2 CDH5	6.12e-04	19	67	2	27671872
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	BPTF TCERG1 FRG1 SMARCC1	6.48e-04	203	67	4	22083510
Pubmed	Oxidized thioredoxin-1 restrains the NLRP1 inflammasome.	IFT81 DPP8	7.50e-04	21	67	2	36332009
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	STXBP5L WDR37 ZKSCAN5	1.02e-03	102	67	3	10231032
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	PAXBP1 RXFP2 ZNF638 SMARCC1 TMEM131 UBN2 PRDM2 TGS1	1.11e-03	1084	67	8	11544199
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	CEP350 MYH9 CCDC59 PAXBP1 UPF2 TCERG1 FRG1 SMARCC1 TTF1	1.22e-03	1371	67	9	36244648
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	XIRP2 RBBP6 IGSF9B ZKSCAN5 ZMYM5	1.45e-03	430	67	5	35044719
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	EIF2D UPF2 TCERG1 ZNF638 SMARCC1 CRYBG3	1.58e-03	650	67	6	38777146
Pubmed	Human transcription factor protein interaction networks.	FLG BPTF CCDC59 TCERG1 RBBP6 ZNF638 SMARCC1 UBN2 PRDM2	1.63e-03	1429	67	9	35140242
Pubmed	Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models.	SYCP2 TEX15	1.75e-03	32	67	2	27739607
Pubmed	ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.	FLG MYH9 VPS13C GBP1	1.81e-03	268	67	4	33024031
Cytoband	2q24.3	XIRP2 SCN2A	2.48e-04	16	67	2	2q24.3
Cytoband	15q22	DPP8 ADAM10	8.30e-04	29	67	2	15q22
Cytoband	3q13.33	STXBP5L POLQ	8.89e-04	30	67	2	3q13.33
Coexpression	BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP	CEP350 SYCP2 CCDC59 RBBP6 DBF4 SMARCC1 GBP1 ZMYM5	6.65e-06	389	67	8	M6520
Coexpression	GSE1460_DP_THYMOCYTE_VS_NAIVE_CD4_TCELL_CORD_BLOOD_UP	PAXBP1 IFT81 ZNF638 SECISBP2 GPSM2 POLQ	1.24e-05	200	67	6	M3459
Coexpression	HAMAI_APOPTOSIS_VIA_TRAIL_UP	CEP350 BPTF CCDC59 DBF4 VPS13C ZNF638 AGGF1 DPP8 POLQ	4.27e-05	656	67	9	M18979
Coexpression	NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP	CEP350 CCDC59 UPF2 RBBP6 DBF4 SMARCC1 TMEM131 DPP8 WDR37 TTF1 ADAM10 PRDM2	5.26e-05	1215	67	12	M41122
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	CEP350 BPTF CCN1 UPF2 DBF4 ZNF638 TMEM131 CRYBG3 WDR37 ADAM10	6.02e-05	856	67	10	M4500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_2500_k-means-cluster#5	CEP350 NRBP2 SFRP2 RBBP6 STXBP5L DBF4 VPS13C GPSM2 POLQ TTF1 TGS1	4.29e-06	654	65	11	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_2500_K5
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3	CEP350 BPTF UPF2 TCERG1 RBBP6 DBF4 IFT81 SMARCC1 GPSM2 UBN2 TTF1 ZMYM5 POLR3F TGS1	2.14e-05	1257	65	14	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_2500_k-means-cluster#1	FMO5 UPF2 TCERG1 ZNF638 SMARCC1 TMEM131 ZKSCAN5 TGS1	8.94e-05	469	65	8	Facebase_RNAseq_e8.5_Floor Plate_2500_K1
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500	CEP350 BPTF UPF2 TCERG1 RBBP6 DBF4 IFT81 SMARCC1 GPSM2 UBN2 TTF1 ZMYM5 POLR3F TGS1	1.08e-04	1459	65	14	facebase_RNAseq_e10.5_Emin_LatNas_2500
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP350 PAXBP1 XIRP2 VPS13C ZNF638 PNPLA8	2.69e-07	176	67	6	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	CEP350 SYCP2 UPF2 RBBP6 ZNF638 TTF1	5.22e-07	197	67	6	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	CEP350 BPTF RBBP6 VPS13C SECISBP2 TGS1	5.37e-07	198	67	6	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CEP350 BPTF PAXBP1 VPS13C GBP1 PRDM2	5.70e-07	200	67	6	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	facs-Lung-Endomucin-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	S100A16 CCN1 STXBP5L AGGF1 ADAM10	8.08e-06	182	67	5	aa113a0d2c1d28bda24cbb1221afd21b5628dc6d
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	BPTF MYH9 RBBP6 VPS13C PRDM2	1.27e-05	200	67	5	7dec470c379cd89f05a0f37c8628b21f136e52f0
Disease	sensorineural hearing loss (is_implicated_in)	WHRN MYH9 GPSM2	4.61e-05	33	62	3	DOID:10003 (is_implicated_in)
Disease	phenylacetylglutamine measurement	SYCP2 RXFP2	2.83e-04	12	62	2	EFO_0021013
Disease	acute graft vs. host disease, donor genotype effect measurement	AGGF1 TMEM131	4.48e-04	15	62	2	EFO_0004599, EFO_0007892
Disease	Nonsyndromic genetic hearing loss	WHRN MYH9 GPSM2	5.57e-04	76	62	3	cv:C5680182
Disease	spermatogenic failure (is_implicated_in)	KCNU1 AKAP3	1.07e-03	23	62	2	DOID:0111910 (is_implicated_in)
Disease	bipolar disorder	WHRN KCNU1 IFT81 SCN2A TMEM131 IGSF9B	1.32e-03	577	62	6	MONDO_0004985
Disease	calcium measurement	ASIC2 STXBP5L IFT81 TMEM131 POLQ ZMYM5	2.03e-03	628	62	6	EFO_0004838

Protein segments in the cluster

Peptide	Gene	Start	Entry
KKKKKSSNREYETLA	TTF1	221	Q15361
KSKIKECISFQSKKT	AGBL3	791	Q8NEM8
QLDIKKSSYKKLSKF	EIF2D	306	P41214
KLEKKSSSYRKKENI	CRYBG3	1036	Q68DQ2
KSKLYSDGKKKSLNT	ADAM10	346	O14672
VYSSLKKGKKCSKTK	CCN1	276	O00622
YPTSSTKQSKDKKLK	AGGF1	261	Q8N302
KSTLLYKLKLAKDIT	ARL14	26	Q8N4G2
GKVKKLKKTSSSDYS	AMZ2	216	Q86W34
KQYSKKDKNTDTLSK	FLG	16	P20930
SYKKKTKSSKLDGLL	BPTF	1176	Q12830
QKKKELYLLKKSSTS	DBF4	181	Q9UBU7
IKSSVSRKNAKYLLK	CDH5	71	P33151
KTSAKYLEKKFNKSE	ASIC2	381	Q16515
SSVYLKEIAKKKNDK	RAD51AP2	271	Q09MP3
YSSTPKQKSKTESKK	INSYN2A	456	Q6ZSG2
VSSGSLKQFLKKTKK	NRBP2	126	Q9NSY0
KGKKYKTNSSTKVLQ	GPSM2	451	P81274
KSVSKQYSLKVTKLE	KIF27	751	Q86VH2
KKAKGKASTLATLKY	PER2	126	O15055
YLTYSLKLKKGTSQK	GBP1	201	P32455
KTSESKKTYNSISKI	GABRA5	411	P31644
SLDKVTLKRTGKSKY	KCNU1	696	A8MYU2
VKSKYKASITALEAK	MYH9	1801	P35579
KVKKSSYSKKIVKLL	PAXBP1	121	Q9Y5B6
KKDYSKDVKSEKLTT	RBBP6	1111	Q7Z6E9
YVKSTKLVLKGTKTK	FRG1	6	Q14331
KKLYSLVSEKKSALA	IFT81	491	Q8WYA0
KLDLITKYNKSKFKQ	FAM83C	726	Q9BQN1
DSVKVVKNKISLYKK	FMO5	341	P49326
QTKSSYKKLTSKNKS	POLQ	926	O75417
KITSILKESKYKRSS	DPP8	481	Q6V1X1
SEIKEIEYTKLKKSK	CEP350	2256	Q5VT06
KEKSVYLSSKLKQLL	PRDM2	681	Q13029
SSLKKNTAFVKKLKT	UPF2	166	Q9HAU5
KQAIKSLKKYSDKSA	PNPLA8	151	Q9NP80
KIILETKSKTIYKLN	SFRP2	211	Q96HF1
IQASTKKFSLEKLYK	TCAIM	426	Q8N3R3
TYSLVNKVKNKKTVS	SCIMP	106	Q6UWF3
RKSIFKIKKKSLSTS	RXFP2	711	Q8WXD0
NKKKKEKSTSKYEVL	SECISBP2	381	Q96T21
SYKKLLRKEKKAQTS	CCDC59	66	Q9P031
IKAVKSVAASKKKVY	POLR3F	136	Q9H1D9
KALKGSKKLVLSVYS	WHRN	206	Q9P202
VKTKKSTKTINPSKY	PIK3CB	411	P42338
LRTDIYSKKTLAKSK	SMARCC1	601	Q92922
LYKLKTSKVFEKQKV	STXBP5L	486	Q9Y2K9
NLKYKSTLKIKESTK	AKAP3	211	O75969
GIYSLKSKRISTKKI	C12orf40	456	Q86WS4
QTFTKKQYLKTKKTE	XIRP2	2566	A4UGR9
LKQIYKTTKNEKIKI	UNC45B	466	Q8IWX7
SEKKKKRYKDSLSLA	UBN2	311	Q6ZU65
DYTKFNTKDLKTEKK	RNASEH2B	261	Q5TBB1
TLLKETKFITYRSKK	TCERG1	1021	O14776
ELSLYKKTKRAISSK	IGSF9B	816	Q9UPX0
KKTKRAISSKKYSVA	IGSF9B	821	Q9UPX0
RKATKTKKNYKDLSN	SYCP2	1016	Q9BX26
KYVSKYSLVKNKISK	S100A16	21	Q96FQ6
GKITVKAKEKSYSKL	TMEM131	406	Q92545
LKQKVKKVSSIYKKD	SCN2A	1921	Q99250
KSYKIAYKNKLTQSK	VPS13C	406	Q709C8
KLKTTYKASTSKIVS	WDR37	121	Q9Y2I8
NSVKYSKLKSDLKKN	ZMYM5	631	Q9UJ78
IKKKKISTVDYILTN	TAS2R8	36	Q9NYW2
FKKSKILSKVEKFLT	TGS1	506	Q96RS0
SEIKKLLKKSKYFIS	TEX15	2166	Q9BXT5
GISKSTFYDIKKNKK	TIGD7	36	Q6NT04
KKTLESKKVSASTLK	ZNF638	761	Q14966
KNTKLSVKKKISEYS	ZKSCAN5	466	Q9Y2L8