Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionNotch binding

JAG2 NOTCH1 NOTCH4

1.69e-0427803GO:0005112
GeneOntologyMolecularFunctionphospholipase C activity

SMPD1 PLCL1 PLCE1

2.10e-0429803GO:0004629
GeneOntologyBiologicalProcessapoptotic process involved in development

JAG2 CCN1 ENPP1 LRP5 NOTCH1

9.81e-0747795GO:1902742
GeneOntologyBiologicalProcessapoptotic process involved in morphogenesis

JAG2 CCN1 LRP5 NOTCH1

6.61e-0632794GO:0060561
DomainEGF_3

JAG2 STAB2 CELSR3 ATRAID LRP5 SSPOP SVEP1 NOTCH1 NOTCH4

8.05e-07235819PS50026
DomainEGF

JAG2 PCSK5 STAB2 CELSR3 ATRAID LRP5 SVEP1 NOTCH1 NOTCH4

8.05e-07235819SM00181
DomainEGF-like_Ca-bd_dom

JAG2 STAB2 CELSR3 LRP5 SVEP1 NOTCH1 NOTCH4

1.11e-06124817IPR001881
DomainEGF

JAG2 STAB2 CELSR3 LRP5 SVEP1 NOTCH1 NOTCH4

1.24e-06126817PF00008
DomainEGF-like_dom

JAG2 PCSK5 STAB2 CELSR3 ATRAID LRP5 SVEP1 NOTCH1 NOTCH4

1.30e-06249819IPR000742
DomainEGF_1

JAG2 STAB2 CELSR3 ATRAID LRP5 SSPOP SVEP1 NOTCH1 NOTCH4

1.59e-06255819PS00022
DomainEGF_2

JAG2 STAB2 CELSR3 ATRAID LRP5 SSPOP SVEP1 NOTCH1 NOTCH4

2.18e-06265819PS01186
DomainGrowth_fac_rcpt_

JAG2 PCSK5 STAB2 CCN1 SVEP1 NOTCH1 NOTCH4

5.13e-06156817IPR009030
DomainhEGF

JAG2 SVEP1 NOTCH1 NOTCH4

6.21e-0628814PF12661
DomainEGF_CA

JAG2 STAB2 CELSR3 SVEP1 NOTCH1 NOTCH4

1.49e-05122816SM00179
DomainEGF-like_CS

JAG2 STAB2 CELSR3 ATRAID LRP5 SVEP1 NOTCH1 NOTCH4

1.74e-05261818IPR013032
DomainOST-HTH/LOTUS_dom

TDRD7 MARF1

5.56e-053812IPR025605
DomainOST-HTH

TDRD7 MARF1

5.56e-053812PF12872
DomainHTH_OST

TDRD7 MARF1

5.56e-053812PS51644
DomainEGF_CA

JAG2 LRP5 SVEP1 NOTCH1 NOTCH4

7.04e-0599815PS01187
DomainASX_HYDROXYL

JAG2 CELSR3 SVEP1 NOTCH1 NOTCH4

7.39e-05100815PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

JAG2 CELSR3 SVEP1 NOTCH1 NOTCH4

9.74e-05106815IPR000152
DomainNotch

NOTCH1 NOTCH4

1.11e-044812IPR008297
DomainNODP

NOTCH1 NOTCH4

1.11e-044812PF07684
DomainNotch_NODP_dom

NOTCH1 NOTCH4

1.11e-044812IPR011656
DomainNotch_NOD_dom

NOTCH1 NOTCH4

1.11e-044812IPR010660
DomainNOD

NOTCH1 NOTCH4

1.11e-044812PF06816
DomainNOD

NOTCH1 NOTCH4

1.11e-044812SM01338
DomainNODP

NOTCH1 NOTCH4

1.11e-044812SM01339
DomainEGF_extracell

JAG2 STAB2 SVEP1 NOTCH1

1.33e-0460814IPR013111
DomainEGF_2

JAG2 STAB2 SVEP1 NOTCH1

1.33e-0460814PF07974
DomainLNR

NOTCH1 NOTCH4

1.84e-045812PS50258
DomainNotch_dom

NOTCH1 NOTCH4

3.85e-047812IPR000800
DomainNotch

NOTCH1 NOTCH4

3.85e-047812PF00066
DomainNL

NOTCH1 NOTCH4

3.85e-047812SM00004
DomainVWFC_1

JAG2 CCN1 SSPOP

5.06e-0436813PS01208
DomainEGF_CA

JAG2 SVEP1 NOTCH1 NOTCH4

5.32e-0486814PF07645
DomainVWC

JAG2 CCN1 SSPOP

5.94e-0438813SM00214
DomainVWFC_2

JAG2 CCN1 SSPOP

5.94e-0438813PS50184
DomainVWF_dom

JAG2 CCN1 SSPOP

7.99e-0442813IPR001007
DomainEGF_Ca-bd_CS

JAG2 SVEP1 NOTCH1 NOTCH4

8.38e-0497814IPR018097
Domain-

STAB2 SVEP1

9.96e-04118122.40.155.10
DomainGFP-like

STAB2 SVEP1

9.96e-0411812IPR023413
DomainPLipase_C_Pinositol-sp_Y

PLCL1 PLCE1

1.88e-0315812IPR001711
DomainEF-hand_like

PLCL1 PLCE1

1.88e-0315812PF09279
DomainPIPLC_Y_DOMAIN

PLCL1 PLCE1

1.88e-0315812PS50008
DomainPI-PLC_fam

PLCL1 PLCE1

1.88e-0315812IPR001192
DomainPLC_EF-hand-like

PLCL1 PLCE1

1.88e-0315812IPR015359
DomainPI-PLC-Y

PLCL1 PLCE1

1.88e-0315812PF00387
DomainPLCYc

PLCL1 PLCE1

1.88e-0315812SM00149
DomainCTCK_1

CCN1 SSPOP

2.72e-0318812PS01185
DomainPI-PLC-X

PLCL1 PLCE1

2.72e-0318812PF00388
DomainPLCXc

PLCL1 PLCE1

2.72e-0318812SM00148
Domainzf-C3HC4

TRIM72 RNF32 LNX2 MARCHF10 NFX1

2.85e-03223815PF00097
DomainZnf_RING

TRIM72 RNF32 RNF223 LNX2 MARCHF10 NFX1

2.92e-03326816IPR001841
DomainVWC_out

JAG2 SSPOP

3.03e-0319812SM00215
DomainPIPLC_X_DOMAIN

PLCL1 PLCE1

3.03e-0319812PS50007
DomainPLipase_C_PInositol-sp_X_dom

PLCL1 PLCE1

3.03e-0319812IPR000909
PathwayPID_NOTCH_PATHWAY

JAG2 RBBP8 SSPOP NOTCH1 NOTCH4

2.19e-0659515M17
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY

JAG2 NOTCH1 NOTCH4

1.24e-0513513M47423
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382

NFX1 NOTCH1 NOTCH4

1.24e-0513513M47534
PathwayKEGG_MEDICUS_VARIANT_NOTCH_OVEREXPRESSION_TO_NOTCH_SIGNALING_PATHWAY

JAG2 NOTCH1 NOTCH4

2.42e-0516513M47424
PathwayWP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING

JAG2 NOTCH1 NOTCH4

1.23e-0427513M39545
PathwayREACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3

NOTCH1 NOTCH4

1.27e-045512M27411
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

NOTCH1 NOTCH4

1.27e-045512MM14733
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM

NOTCH1 NOTCH4

1.91e-046512M27068
PathwayREACTOME_SIGNALING_BY_NOTCH1_T_7_9_NOTCH1_M1580_K2555_TRANSLOCATION_MUTANT

JAG2 NOTCH1

2.66e-047512M27199
PathwayREACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING

NOTCH1 NOTCH4

2.66e-047512MM14734
PathwayREACTOME_SIGNALING_BY_NOTCH

JAG2 NOTCH1 NOTCH4

3.72e-0439513MM14604
PathwayREACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS

JAG2 NOTCH1

5.67e-0410512MM14849
PathwayWP_NOTCH_SIGNALING_WP268

JAG2 NOTCH1 NOTCH4

5.69e-0445513M39571
PathwayWP_NOTCH_SIGNALING_PATHWAY

JAG2 NOTCH1 NOTCH4

6.07e-0446513MM15971
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

JAG2 NOTCH1 NOTCH4

6.47e-0447513M7946
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION

NOTCH1 NOTCH4

6.91e-0411512M47865
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380

NOTCH1 NOTCH4

8.28e-0412512M47532
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381

NOTCH1 NOTCH4

8.28e-0412512M47533
PathwayWP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES

JAG2 LRP5 NOTCH1 NOTCH4

8.61e-04118514M39852
PathwayWP_GPR40_PATHWAY

PLCL1 PLCE1

1.31e-0315512M39526
PathwayREACTOME_SIGNALING_BY_NOTCH1_HD_DOMAIN_MUTANTS_IN_CANCER

JAG2 NOTCH1

1.31e-0315512M27202
PathwayWP_NOTCH_SIGNALING_WP61

JAG2 NOTCH1 NOTCH4

1.38e-0361513M39540
PathwayWP_NOTCH1_REGULATION_OF_ENDOTHELIAL_CELL_CALCIFICATION

JAG2 NOTCH1

1.69e-0317512M39389
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

SSPOP NOTCH1 B3GAT3 NOTCH4

1.75e-03143514M27275
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

NOTCH1 NOTCH4

1.89e-0318512M614
PathwayREACTOME_SIGNALING_BY_NOTCH1

JAG2 NOTCH1

1.89e-0318512MM14775
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

SSPOP NOTCH1 NOTCH4

1.89e-0368513M27303
Pubmed

Human ligands of the Notch receptor.

JAG2 NOTCH1 NOTCH4

5.07e-07786310079256
Pubmed

The distribution of Notch receptors and their ligands during articular cartilage development.

JAG2 NOTCH1 NOTCH4

5.07e-07786312846471
Pubmed

Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.

JAG2 NOTCH1 NOTCH4

8.10e-0788639858718
Pubmed

Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system.

JAG2 NOTCH1 NOTCH4

1.21e-06986311118901
Pubmed

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.

JAG2 NOTCH1 NOTCH4

1.21e-06986316245338
Pubmed

Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad.

JAG2 NOTCH1 NOTCH4

1.21e-06986311944948
Pubmed

Notch signaling is essential for vascular morphogenesis in mice.

JAG2 NOTCH1 NOTCH4

1.21e-06986310837027
Pubmed

Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.

JAG2 NOTCH1 NOTCH4

1.73e-061086323665443
Pubmed

Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development.

JAG2 NOTCH1 NOTCH4

2.37e-061186316607638
Pubmed

Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators.

JAG2 NOTCH1 NOTCH4

2.37e-061186310878608
Pubmed

Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions.

JAG2 NOTCH1 NOTCH4

2.37e-061186312866128
Pubmed

Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.

JAG2 NOTCH1 NOTCH4

3.16e-061286315465494
Pubmed

Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

JAG2 NOTCH1 NOTCH4

4.10e-061386311578869
Pubmed

Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1.

JAG2 NOTCH1 NOTCH4

5.21e-061486318528438
Pubmed

Molecular Profiling of the Developing Lacrimal Gland Reveals Putative Role of Notch Signaling in Branching Morphogenesis.

JAG2 NOTCH1 NOTCH4

5.21e-061486328192800
Pubmed

Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.

JAG2 NOTCH1 NOTCH4

5.21e-061486314757642
Pubmed

Introduction to Notch signaling.

NOTCH1 NOTCH4

6.04e-06286225053477
Pubmed

Differential patterns of NOTCH1-4 receptor expression are markers of glioma cell differentiation.

NOTCH1 NOTCH4

6.04e-06286224305720
Pubmed

Notch signaling in cancer.

NOTCH1 NOTCH4

6.04e-06286212496471
Pubmed

Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease.

NPC1 SMPD1

6.04e-0628627670466
Pubmed

Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes.

JAG2 NOTCH1

6.04e-06286211700865
Pubmed

Niemann-Pick disease.

NPC1 SMPD1

6.04e-06286210608504
Pubmed

Comprehensive Evaluation of Plasma 7-Ketocholesterol and Cholestan-3β,5α,6β-Triol in an Italian Cohort of Patients Affected by Niemann-Pick Disease due to NPC1 and SMPD1 Mutations.

NPC1 SMPD1

6.04e-06286226790753
Pubmed

Inhibition of Notch pathway attenuates the progression of human immunodeficiency virus-associated nephropathy.

NOTCH1 NOTCH4

6.04e-06286223389453
Pubmed

Notch signaling: from the outside in.

NOTCH1 NOTCH4

6.04e-06286211112321
Pubmed

Clinicopathological significance of aberrant Notch receptors in intrahepatic cholangiocarcinoma.

NOTCH1 NOTCH4

6.04e-06286225031748
Pubmed

Thymosin beta4 induces angiogenesis through Notch signaling in endothelial cells.

NOTCH1 NOTCH4

6.04e-06286223749167
Pubmed

[Expression and significance of Notch-1 and Jagged-2 in patients with Hirschsprung disease].

JAG2 NOTCH1

6.04e-06286222030773
Pubmed

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling.

NPC1 SMPD1

6.04e-0628628181053
Pubmed

Biochemical, pathological, and clinical response to transplantation of normal bone marrow cells into acid sphingomyelinase-deficient mice.

NPC1 SMPD1

6.04e-0628629565090
Pubmed

Critical role of endothelial Notch1 signaling in postnatal angiogenesis.

NOTCH1 NOTCH4

6.04e-06286217158336
Pubmed

Notch-1 and Notch-4 biomarker expression in triple-negative breast cancer.

NOTCH1 NOTCH4

6.04e-06286222084425
Pubmed

Notch-1 and notch-4 receptors as prognostic markers in breast cancer.

NOTCH1 NOTCH4

6.04e-06286220444726
Pubmed

Human papillomavirus 16E6 and NFX1-123 potentiate Notch signaling and differentiation without activating cellular arrest.

NFX1 NOTCH1

6.04e-06286225723053
Pubmed

Mouse models of Niemann-Pick disease: mutation analysis and chromosomal mapping rule out the type A and B forms.

NPC1 SMPD1

6.04e-0628628288255
Pubmed

Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease).

NPC1 SMPD1

6.04e-0628627600574
Pubmed

Downregulation of Notch-1/Jagged-2 in human colon tissues from Hirschsprung disease patients.

JAG2 NOTCH1

6.04e-06286221892607
Pubmed

NFX1-123 and human papillomavirus 16E6 increase Notch expression in keratinocytes.

NFX1 NOTCH1

6.04e-06286224109236
Pubmed

Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells.

JAG2 NOTCH1

6.04e-06286223074278
Pubmed

Notch1 and Notch4 are markers for poor prognosis of hepatocellular carcinoma.

NOTCH1 NOTCH4

6.04e-06286223742774
Pubmed

Hepatitis B virus X protein activates Notch signaling by its effects on Notch1 and Notch4 in human hepatocellular carcinoma.

NOTCH1 NOTCH4

6.04e-06286226530164
Pubmed

Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.

JAG2 NOTCH1 NOTCH4

6.50e-061586312971992
Pubmed

Expression of Notch pathway components in fetal and adult mouse small intestine.

JAG2 NOTCH1 NOTCH4

7.99e-061686312617809
Pubmed

Notch gene expression during pancreatic organogenesis.

JAG2 NOTCH1 NOTCH4

7.99e-061686310842072
Pubmed

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

JAG2 NOTCH1 NOTCH4

7.99e-061686317273555
Pubmed

Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.

JAG2 NOTCH1 NOTCH4

9.68e-061786318694942
Pubmed

Segmental expression of Notch and Hairy genes in nephrogenesis.

JAG2 NOTCH1 NOTCH4

9.68e-061786315821257
Pubmed

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling.

JAG2 NOTCH1 NOTCH4

1.16e-051886318093989
Pubmed

RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells.

JAG2 NOTCH1 NOTCH4

1.16e-051886315689374
Pubmed

Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium.

JAG2 NOTCH1 NOTCH4

1.37e-051986316518823
Pubmed

Notch receptor expression in human brain arteriovenous malformations.

NOTCH1 NOTCH4

1.81e-05386225846406
Pubmed

Sequential expressions of Notch1, Jagged2 and Math1 in molar tooth germ of mouse.

JAG2 NOTCH1

1.81e-05386219181188
Pubmed

Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches.

NOTCH1 NOTCH4

1.81e-05386218593923
Pubmed

Characterization of Notch Signalling Pathway Members in Normal Prostate, Prostatic Intraepithelial Neoplasia (PIN) and Prostatic Adenocarcinoma.

NOTCH1 NOTCH4

1.81e-05386226341090
Pubmed

Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.

LMO2 NOTCH1

1.81e-05386221670468
Pubmed

ZEB2 alleviates Hirschsprung's-associated enterocolitis by promoting the proliferation and differentiation of enteric neural precursor cells via the Notch-1/Jagged-2 pathway.

JAG2 NOTCH1

1.81e-05386238485033
Pubmed

Differential expression of Notch genes in human osteoblastic cells.

NOTCH1 NOTCH4

1.81e-05386211836628
Pubmed

Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction.

JAG2 NOTCH1

1.81e-05386218458347
Pubmed

A lysosomal storage disorder in mice characterized by a dual deficiency of sphingomyelinase and glucocerebrosidase.

NPC1 SMPD1

1.81e-0538626257302
Pubmed

Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation.

NOTCH1 NOTCH4

1.81e-05386214988227
Pubmed

Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies.

LMO2 NOTCH1

1.81e-05386221427293
Pubmed

Delta-like 4/Notch pathway is differentially regulated in benign and malignant thyroid tissues.

NOTCH1 NOTCH4

1.81e-05386222066479
Pubmed

Unique patterns of Notch1, Notch4 and Jagged1 expression in ovarian vessels during folliculogenesis and corpus luteum formation.

NOTCH1 NOTCH4

1.81e-05386215939383
Pubmed

Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease.

NOTCH1 NOTCH4

1.81e-05386219546852
Pubmed

The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cells.

NPC1 SMPD1

1.81e-05386237407594
Pubmed

NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications.

NOTCH1 NOTCH4

1.81e-05386221679465
Pubmed

Tumor suppressor role of phospholipase C epsilon in Ras-triggered cancers.

PLCL1 PLCE1

1.81e-05386224591640
Pubmed

Notch signaling: cell fate control and signal integration in development.

NOTCH1 NOTCH4

1.81e-05386210221902
Pubmed

The Notch-mediated circuitry in the evolution and generation of new cell lineages: the tooth model.

JAG2 NOTCH1

1.81e-05386237330998
Pubmed

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.

NOTCH1 NOTCH4

1.81e-05386228871079
Pubmed

Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis.

NPC1 SMPD1

1.81e-05386216950136
Pubmed

Notch1 is pan-endothelial at the onset of flow and regulated by flow.

NOTCH1 NOTCH4

1.81e-05386225830332
Pubmed

Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception.

JAG2 NOTCH1 NOTCH4

1.88e-052186328656980
Pubmed

Conversion of biliary system to pancreatic tissue in Hes1-deficient mice.

JAG2 NOTCH1 NOTCH4

1.88e-052186314702043
Pubmed

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.

JAG2 NOTCH1 NOTCH4

2.49e-052386314701881
Pubmed

Rbpj regulates development of prosensory cells in the mammalian inner ear.

JAG2 NOTCH1 NOTCH4

2.85e-052486321420948
Pubmed

Prognostic roles of mRNA expression of notch receptors in non-small cell lung cancer.

NOTCH1 NOTCH4

3.61e-05486228061457
Pubmed

The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors.

NOTCH1 NOTCH4

3.61e-05486224145721
Pubmed

A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma.

NOTCH1 NOTCH4

3.61e-05486220069356
Pubmed

A mutation in the Lunatic fringe gene suppresses the effects of a Jagged2 mutation on inner hair cell development in the cochlea.

JAG2 NOTCH1

3.61e-05486210837254
Pubmed

ADAM10-Dependent Signaling Through Notch1 and Notch4 Controls Development of Organ-Specific Vascular Beds.

NOTCH1 NOTCH4

3.61e-05486227354212
Pubmed

Expression and clinical significance of Notch receptors in human renal cell carcinoma.

NOTCH1 NOTCH4

3.61e-05486219404845
Pubmed

Notch signaling pathway regulates the growth and the expression of inflammatory cytokines in mouse basophils.

NOTCH1 NOTCH4

3.61e-05486228669409
Pubmed

Notch signalling pathway mediates hair cell development in mammalian cochlea.

JAG2 NOTCH1

3.61e-05486210080181
Pubmed

Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor.

JAG2 NOTCH1

3.61e-0548629315665
Pubmed

Evolutionary analysis of vertebrate Notch genes.

NOTCH1 NOTCH4

3.61e-05486211466531
Pubmed

Abnormal expression pattern of Notch receptors, ligands, and downstream effectors in the dorsolateral prefrontal cortex and amygdala of suicidal victims.

NOTCH1 NOTCH4

3.61e-05486224151014
Pubmed

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin.

NOTCH1 NOTCH4

3.61e-05486217984306
Pubmed

Activation of Notch signaling in human tongue carcinoma.

JAG2 NOTCH1

3.61e-05486220819128
Pubmed

Characterization and developmental expression of the amphioxus homolog of Notch (AmphiNotch): evolutionary conservation of multiple expression domains in amphioxus and vertebrates.

NOTCH1 NOTCH4

3.61e-05486211401408
Pubmed

Notch as a mediator of cell fate determination in hematopoiesis: evidence and speculation.

NOTCH1 NOTCH4

3.61e-05486210194420
Pubmed

Functional conservation of mouse Notch receptor family members.

NOTCH1 NOTCH4

3.61e-0548628898100
Pubmed

Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties.

NOTCH1 NOTCH4

3.61e-05486236376768
Pubmed

Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members.

NOTCH1 NOTCH4

3.61e-05486211459941
Pubmed

Notch1 deficiency results in decreased inflammation during wound healing and regulates vascular endothelial growth factor receptor-1 and inflammatory cytokine expression in macrophages.

NOTCH1 NOTCH4

3.61e-05486220739676
Pubmed

Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias.

NOTCH1 NOTCH4

3.61e-05486218184405
Pubmed

Detection of Notch signaling molecules in cemento-ossifying fibroma of the jaws.

JAG2 NOTCH1

3.61e-05486220040020
Pubmed

Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and recurrence risk in ER-negative breast cancer.

NOTCH1 NOTCH4

3.61e-05486235543859
Pubmed

Notch signaling in the mammalian central nervous system: insights from mouse mutants.

NOTCH1 NOTCH4

3.61e-05486215917835
Pubmed

The Notch signalling pathway in hair growth.

JAG2 NOTCH1

3.61e-0548629858728
InteractionIGFL3 interactions

JAG2 PCSK5 UBR5 LRP5 NOTCH1 NXPE3

6.07e-0775826int:IGFL3
GeneFamilyRing finger proteins

TRIM72 RNF32 RNF223 LNX2 MARCHF10

5.25e-0427544558
GeneFamilyPhospholipases|C2 domain containing phospholipases

PLCL1 PLCE1

9.64e-0419442832
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

MARF1 PPP1R3F PLCL1 LMTK3

9.65e-04181444694
GeneFamilyAnkyrin repeat domain containing

DZANK1 ANKRD6 NOTCH1 NOTCH4

2.79e-03242444403
CoexpressionJIANG_TIP30_TARGETS_UP

PPARGC1B CCN1 ENPP1 RAD17

1.59e-0546864M12641
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

JAG2 NOTCH1 NOTCH4

1.85e-0516863MM1296
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

JAG2 NOTCH1 NOTCH4

1.85e-0516863M2207
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

JAG2 PCSK5 DHH LMO2 XAF1 NOTCH4

1.81e-061898666463890d8dbee4bc198f91628a5f784970de786a
ToppCellIIH-CD4-CD8_2|IIH / Condition, Cell_class and T cell subcluster

RNF32 DZANK1 CFAP92 MARCHF10 ZNF683

6.95e-061378655614a086f5f698e0965f3c7699cffefec5c3b87e
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TDRD7 CDAN1 CCN1 NOTCH1 NXPE3

1.61e-0516386563b0badaee3b2d827b1f4524510e3384d8f8fcde
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 DHH OAZ2 NOTCH1 NOTCH4

1.76e-051668657a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 DHH OAZ2 NOTCH1 NOTCH4

1.76e-05166865bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCellBronchial_Biopsy-Endothelial-Lymphatic|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

STAB2 SLC9A5 SGIP1 PMEL SSPOP

2.09e-05172865c41f5a66781bbf63afce7ca5d118cc6d8e0fe0bc
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-arterial_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

JAG2 PCSK5 DHH LMO2 NOTCH4

2.15e-051738653a9e9a09b3eeb37cbe56d650e112a8398879477f
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NUDT18 LNX2 STAB2 LMO2 NOTCH1

2.27e-0517586543be63976da5ad0764d24d90919a77ce46068f52
ToppCell3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JAG2 DHH CCN1 XAF1 NOTCH4

2.46e-05178865e2363810d77b6b245394a666eb51bacd345c43f7
ToppCellP03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK5 DHH OAZ2 NOTCH1 NOTCH4

3.12e-0518786566ebe1788d51b3e17bec6cdb219f709756b4e530
ToppCellP07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK5 DHH OAZ2 NOTCH1 NOTCH4

3.20e-051888655bc1537e079c7435196c163bff5f639ea392a33a
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

JAG2 CCN1 LMO2 XAF1 NOTCH4

3.20e-05188865a37edd8f9e4a4e336b5acbb0407d3d275975cee8
ToppCelldroplet-Kidney-KIDNEY-30m-Endothelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG2 DHH LMO2 XAF1 NOTCH4

3.36e-05190865cb8798839c27f307955fcc94a1ee40bca95b8e99
ToppCelldroplet-Kidney-KIDNEY-30m-Endothelial-kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG2 DHH LMO2 XAF1 NOTCH4

3.36e-051908655bf3d0beee69879c95265d07fba023626a7cc808
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

JAG2 PCSK5 DHH XAF1 NOTCH4

3.45e-05191865b2c86cde341fe350143658c8a8a4a9edbce3f19b
ToppCelldroplet-Kidney-nan-18m-Endothelial-kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG2 PCSK5 DHH LMO2 NOTCH4

3.54e-05192865144503af50274eaed5cf6effa892c640eab28663
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

JAG2 DHH LMO2 TBC1D1 NOTCH4

3.54e-051928653259cb89d6bcf0a3c6ff1f64d85e8a1f54124e91
ToppCelldroplet-Kidney-nan-18m-Endothelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG2 PCSK5 DHH LMO2 NOTCH4

3.54e-05192865c96736bb3a6bb052678b1b078f7823063ca69e6d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

JAG2 PCSK5 LMO2 XAF1 NOTCH4

3.54e-0519286556b021c297a21dff357531f21e2464f85186106d
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

JAG2 DHH LMO2 XAF1 NOTCH4

3.62e-05193865cc355b2ed6510619cad969ae074126d7c8db784d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

JAG2 DHH LMO2 XAF1 NOTCH4

3.62e-051938656a623acd1adad9a78eddc32ffedb16352ad3fdfa
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

JAG2 DHH LMO2 XAF1 NOTCH4

3.71e-05194865b0c15e7e4bcf30856fb628dedd7ba82df33489f5
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JAG2 PCSK5 DHH LMO2 NOTCH4

3.81e-05195865b0979c1b5e4576468b8fe4e9027650859e598b34
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

JAG2 DHH LMO2 NOTCH1 NOTCH4

3.90e-05196865a20a56d8997d6db2a10046c8801c619a379de83c
ToppCell(07)_Ionocytes-(0)_Reference|(07)_Ionocytes / shred by cell type by condition

TRIM72 HMGN2P46 CLCNKA SMPD1 OAZ2

3.90e-051968654ac33e7d11b8b0fff6ee2e9dacad49c21d63b818
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

JAG2 PCSK5 DHH LMO2 NOTCH4

4.09e-051988655e781583908c4ee107d986904a646a7c6b8e3591
ToppCell5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JAG2 DHH CCN1 LMO2 NOTCH4

4.09e-0519886558508a8df2714d769f137794c29441a7bd38b350
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JAG2 STAB2 LMO2 NOTCH1 NOTCH4

4.19e-05199865f0bf75bfae7b288ecb6801be458b03ebd0108ea7
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

JAG2 PCSK5 DHH LMO2 NOTCH4

4.29e-0520086593e13937ec74418a697c37d56f57509fb2154780
ToppCellLPS_only-Unknown-Endothelial|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC9A5 SGIP1 PMEL PLCE1

7.32e-05115864ad5298c2ad8bf94fa13c2e50b0799e929473ef59
ToppCellLPS_only-Unknown|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC9A5 SGIP1 PMEL PLCE1

7.32e-051158647a733f6987b40ec497a03734b79ed5355ad3a2fc
ToppCellLPS_only-Unknown-Endothelial-Pericyte_2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC9A5 SGIP1 PMEL PLCE1

7.32e-05115864c67145d3cd9243994a141749b426ff2a6dcc8d93
ToppCellNS-moderate-d_07-13-Epithelial-unknown_epithelial|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

RNF223 ZNF821 CCN1 ENPP1

1.18e-041308641491e8975520e99c527a5b5bee64875d124f7bf4
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|367C / Donor, Lineage, Cell class and subclass (all cells)

CDAN1 ZNF683 NOTCH1 NXPE3

1.21e-04131864cc5b5afab8622e98f673fa116a226d930c295327
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Stem_cells-neuroepithelial-like_cells|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

LMO2 ENPP1 LRRC69 NOTCH4

1.28e-04133864bdaba11e8d9868eca57c3c976e381ee096d39ddf
ToppCellPBMC-Severe-cDC_8|Severe / Compartment, Disease Groups and Clusters

RNF223 PPP1R3F PLCL1 NOTCH4

1.79e-0414586423a9a4fd1934c4a38d9259105c1fdbac459575cb
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AP4E1 MARCHF10 PMEL LMTK3

2.04e-0415086447ea08d7609e1d2382bf56ef9e5c767e3597cf93
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|390C / Donor, Lineage, Cell class and subclass (all cells)

C11orf21 ZNF683 SSPOP PABIR3

2.04e-04150864fdbfc8f743cf848978cf0488493f6df60be53982
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

LMO2 PIH1D2 XAF1 CLEC10A

2.49e-04158864216b3f482daa2d0d7fcaf5a8559e3ccbdb8e110d
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LMO2 PIH1D2 XAF1 CLEC10A

2.49e-041588649712bb8b1bacb8a38c99a22bc2babec5d5160e2a
ToppCellBronchial_Biopsy-Endothelial-Lymphatic|Endothelial / Tissue, Lineage and Cell class of Lung Cells from 10X

STAB2 SLC9A5 PMEL SSPOP

2.80e-04163864961c3a1303108afd680365466045f3460a30a7b0
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_3|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

RNF32 WDR3 ASPDH NXPE3

2.86e-04164864583dda853cee9491dbdcb228c23d8deadc20eb08
ToppCell390C-Lymphocytic-ILC|390C / Donor, Lineage, Cell class and subclass (all cells)

JAG2 CDAN1 ENPP1 ZNF683

2.86e-04164864b0fc63b72162b5cc4d1e0a271a12f3d3ab29398f
ToppCellAdult-Mesenchymal-chondrocyte-D231|Adult / Lineage, Cell type, age group and donor

SPATA2L REXO5 SGIP1 SVEP1

2.86e-041648642ba57dce5f69a88f0d1e450b9780425e2d9ca7d4
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

STAB2 LMO2 ANKRD6 PLCE1

2.93e-0416586450a8513d8d2630861499393a7f102b35366bad37
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

JAG2 LMO2 XAF1 NOTCH4

2.93e-04165864a74751e0ec857aa974bec04ccc747c004a8f6e01
ToppCellBAL-Mild-Myeloid-MoAM-MoAM5-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TRIM72 RNF223 CCN1 CLEC10A

3.00e-04166864006ced12f69ef13ddcba5a3891ddc7c18c384863
ToppCellBAL-Mild-Myeloid-MoAM-MoAM5|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TRIM72 RNF223 CCN1 CLEC10A

3.00e-04166864ac28c8cac1e94be0c47fb862c5809c92cdaa11f3
ToppCellBAL-Mild-Myeloid-MoAM-MoAM5-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TRIM72 RNF223 CCN1 CLEC10A

3.00e-041668646bb3410e65c971acc458c472015afcec6de6e310
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

JAG2 LMO2 PLCL1 NOTCH4

3.00e-041668648e2faca6a2e76a625de04d6098aa6f98911945c6
ToppCellBAL-Mild-Myeloid-MoAM-MoAM5|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

TRIM72 RNF223 CCN1 CLEC10A

3.00e-04166864823ec03714884cb860a1260410feac8c536b6d06
ToppCell10x5'-Lung-Lymphocytic_T_CD4/8-lo-Trm_Tgd|Lung / Manually curated celltypes from each tissue

JAG2 ZNF821 ZNF683 RAD17

3.07e-04167864dcbcc658082910838c8082d71a64917055086cc4
ToppCell390C-Lymphocytic-ILC-ILC-2|390C / Donor, Lineage, Cell class and subclass (all cells)

JAG2 CDAN1 ENPP1 ZNF683

3.14e-041688642781dd6b369427a94c5059b44b4c8f023f5f2988
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

JAG2 LMO2 XAF1 NOTCH4

3.21e-04169864c7fc3a8c44f07c557b60d469717b66e2f5863d38
ToppCellMild_COVID-19-Myeloid-MoAM5|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

TRIM72 RNF223 CCN1 CLEC10A

3.28e-04170864b2daf46ab5a49590ede8f75e4240bfe6e9d8b764
ToppCell390C-Lymphocytic-ILC|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

JAG2 CDAN1 ENPP1 ZNF683

3.36e-0417186470963f79711fe6088d6d01b29206b17ab89e5e73
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

TDRD7 CDAN1 NOTCH1 NXPE3

3.43e-04172864da959c1abadafd79b7a0088a25eb8ef8efa3a0c2
ToppCell390C-Lymphocytic-ILC-ILC-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

JAG2 CDAN1 ENPP1 ZNF683

3.43e-0417286484d16cd7f618c94888920680bdc9e7130d73fd75
ToppCellfacs-Heart-LV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPARGC1B TBC1D1 PLCL1 SSPOP

3.51e-04173864d78397e65e997ddb995111a810f0e2a4f67d0765
ToppCellfacs-Heart-LV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPARGC1B TBC1D1 PLCL1 SSPOP

3.51e-041738643c852ffe22f4a5b632463086b08c669310684e80
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

JAG2 DHH LMO2 NOTCH4

3.58e-041748643d4c05ea5719ca65e85d1f15198453034791087c
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 DHH LMO2 NOTCH4

3.74e-0417686496779273b94345250cf53ba671203345b43d9e00
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-like-AT1_Progenitor|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AP5Z1 ARHGEF9 LRRC61 SVEP1

3.82e-04177864164ffbbf798defa3728197deb1a14b661490e525
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

JAG2 PCSK5 DHH NOTCH4

3.82e-041778645ff8dcfb030312126695d53a026d2e104a401b83
ToppCell3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

STAB2 MARCHF10 CLCNKA TBC1D1

3.82e-041778646d89042bda8e244babb68929e84b25edcb545a77
ToppCell3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

STAB2 MARCHF10 CLCNKA TBC1D1

3.82e-04177864daaccf1249dcf816df4caca695a944f53078291a
ToppCell3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

STAB2 MARCHF10 CLCNKA TBC1D1

3.82e-04177864338bdda26796bf4e16072878c070212d1006cf57
ToppCelldroplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF821 LNX2 STAB2 LMTK3

3.82e-041778648ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCell3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

STAB2 MARCHF10 CLCNKA TBC1D1

3.82e-04177864c5a16f984c836dbf7d0faf061677844167ab612a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

JAG2 DHH LMO2 NOTCH4

3.91e-041788645f779a66aa42d1d8e8af17b4a08d5dcc733efd4c
ToppCellPCW_13-14-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

JAG2 DHH LMO2 NOTCH4

3.91e-04178864c227da59dc7beb73f84405bf13356bdeb59d9338
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

JAG2 PCSK5 LMO2 NOTCH4

3.99e-041798641ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SGIP1 CCN1 ENPP1 SVEP1

4.07e-04180864280ff5c8f292be1b88120db5ff1788b750644856
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SGIP1 CCN1 ENPP1 SVEP1

4.07e-04180864fdbd7c22044d9328a1e06e2f9a4451529d1df767
ToppCellPCW_05-06-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

JAG2 DHH LMO2 NOTCH4

4.07e-041808645861b44acfb8fe92c281c8355bf19c059b3dcd64
ToppCelldroplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF821 LNX2 STAB2 LMTK3

4.16e-041818644df7972f88117108698efd06b124b232f8588981
ToppCellfacs-Heart-LV-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SGIP1 TBC1D1 PLCL1 SSPOP

4.16e-041818641db1eb7d330a7e5090994007ae287e11f0a74450
ToppCellfacs-Heart-LV-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SGIP1 TBC1D1 PLCL1 SSPOP

4.16e-0418186406174ce9240c9261c0f51a1b0d875335d60722e5
ToppCelldroplet-Liver-hepatocytes-3m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF821 LNX2 STAB2 LMTK3

4.16e-04181864cbb530566893281289026bfd93adf721decd4ca3
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JAG2 PCSK5 DHH LMO2

4.16e-041818640ba91575fe8851788cebc4cf5a6d76680bf586c5
ToppCellASK454-Epithelial|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

CFAP92 CCN1 RBBP8 PLCE1

4.25e-04182864ab15316cff989b61ff397a866d7ca8b49c13e981
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JAG2 LMO2 NOTCH1 NOTCH4

4.25e-041828640346f81bbb1f309f3e9d063b20547d548d09472c
ToppCellIIH-Treg-proli_CD4|IIH / Condition, Cell_class and T cell subcluster

NUDT18 PARG ARHGEF9 SSH2

4.25e-041828645c7d02da9ca2bca49db9832704b6894dfaa08a71
ToppCellE16.5-samps-Endothelial-Immature_fetal_endothelial-Intermediate_Endothelial|E16.5-samps / Age Group, Lineage, Cell class and subclass

JAG2 STAB2 LMO2 NOTCH4

4.25e-04182864fec1caf867b1dc87b24504d895ee1a27df78062e
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 DHH NOTCH1 NOTCH4

4.34e-041838643427f3cbe6ea81709750e7dd3ff378f03ae65eab
ToppCellPCW_10-12-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

JAG2 DHH LMO2 NOTCH4

4.43e-04184864a809b0fa52df8a159f60f87eefcef61220af5e34
ToppCellmetastatic_Brain-Endothelial_cells-Stalk-like_ECs|metastatic_Brain / Location, Cell class and cell subclass

DHH CCN1 LMO2 NOTCH4

4.52e-04185864ad52970e88e8947ef256095bd4b40229b912d58a
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

REXO5 CFAP92 PIH1D2 RREB1

4.52e-0418586405bc89a566b0db90ae06506e067190a4739a0974
ToppCell343B-Endothelial_cells-Endothelial-E-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PPARGC1B ENPP1 XAF1 NOTCH4

4.61e-04186864dae6a98963c78bf7518ebab8dc02f173c3b0f7f7
ToppCell343B-Endothelial_cells-Endothelial-E|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PPARGC1B ENPP1 XAF1 NOTCH4

4.61e-04186864080e56113b89138277a2bd2eabddfa6cd1a18b61
ToppCellfacs-Heart-LA-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPARGC1B SGIP1 TBC1D1 PLCL1

4.70e-04187864a12f383b02b07af32cc53a154685df8dba8fbd3f
ToppCellfacs-Heart-LA-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPARGC1B SGIP1 TBC1D1 PLCL1

4.70e-04187864c40c152fa14e6afc9188549534b64ccbaded56b3
ToppCell3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JAG2 LMO2 NOTCH1 NOTCH4

4.70e-0418786425efb82afe863a853ecdd781ad89026c993aaa67
ToppCelldroplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG2 PCSK5 DHH NOTCH4

4.70e-04187864e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCellwk_08-11-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

JAG2 DHH LMO2 NOTCH4

4.70e-04187864a27aa97aa6508a3ffe92c2b6bb0511a95650a390
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

JAG2 DHH NOTCH1 NOTCH4

4.80e-04188864366a2d59b9c81d8a7659749f9c07efa46b49a39a
ToppCellP15-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK5 DHH NOTCH1 NOTCH4

4.80e-0418886450b27fc12347ca16bd62333baf345c83cb422a8f
ToppCellE17.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PCSK5 DHH LMO2 NOTCH1

4.80e-0418886459f276e23c8380bae57d7ecca3a8b83df4bc150b
ToppCellASK454-Epithelial-Type_1|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

CCN1 RBBP8 PPP1R3F PLCE1

4.80e-0418886413f8ce8f24ac7d7ed87f4ae3b8f4096de29383c2
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

JAG2 PCSK5 DHH NOTCH4

4.80e-04188864c2c51c6526defe2600302901159b8abbb58d7595
Drug2-propylpentanoic acid; Up 200; 500uM; MCF7; HT_HG-U133A_EA

JAG2 ZNF821 DZANK1 RPAP1 SCAPER ANKRD6 NXPE3

7.62e-061948471020_UP
DrugBoldine [476-70-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A

STAB2 CELSR3 LMO2 SCAPER NFX1 SMPD1 NOTCH1

8.14e-061968474122_DN
DrugAminophylline [317-34-0]; Down 200; 9.6uM; MCF7; HT_HG-U133A

NUDT18 GPR137 AP5Z1 SMPD1 ANKRD6 NOTCH1 NXPE3

8.14e-061968473374_DN
DrugSB 203580; Up 200; 1uM; MCF7; HT_HG-U133A

ZNF821 SPATA2L DZANK1 RPAP1 LMO2 AP5Z1 SMPD1

8.42e-061978477061_UP
DiseaseSphingomyelin/cholesterol lipidosis

NPC1 SMPD1

2.17e-053802cv:C0028064
DiseaseCarcinoma, Pancreatic Ductal

JAG2 NOTCH1 NOTCH4

3.73e-0524803C0887833
DiseaseNiemann-Pick disease (implicated_via_orthology)

NPC1 SMPD1

4.34e-054802DOID:14504 (implicated_via_orthology)
DiseaseLeukemia, T-Cell

LMO2 NOTCH1

7.22e-055802C0023492
Diseasehemangiopericytoma (is_marker_for)

NOTCH1 NOTCH4

2.58e-049802DOID:264 (is_marker_for)
Diseasegastric adenocarcinoma (is_implicated_in)

UBR5 PLCE1

3.93e-0411802DOID:3717 (is_implicated_in)
DiseaseMalignant lymphoma, lymphocytic, intermediate differentiation, diffuse

UBR5 NOTCH1

8.50e-0416802C0334634
Diseaseinflammatory bowel disease

PCSK5 CELSR3 TBC1D1 PLCL1 NOTCH1 NOTCH4

1.40e-03449806EFO_0003767
Diseaseorofacial cleft, sex interaction measurement

C11orf21 NOTCH4 PLCE1

1.67e-0386803EFO_0008343, MONDO_0000358
DiseaseObesity

NPC1 PPARGC1B ENPP1 TBC1D1

2.37e-03205804C0028754

Protein segments in the cluster

PeptideGeneStartEntry
QLGQPCDCLPPLRAA

B3GAT3

26

O94766
GEPCSQECIILQPLN

RBBP8

551

Q99708
LCNLLKIAPPAVCQS

SMPD1

121

P17405
IPLCPQELSLPNLGC

CCN1

131

O00622
LRCHECQQLLPSIPQ

APTX

331

Q7Z2E3
PACPEQLQVLCAAIL

AP5Z1

76

O43299
PLLAGTHCLPCSQQL

CFAP92

386

Q9ULG3
PAQLLEILCSQLCPH

CDAN1

911

Q8IWY9
QAPINGCRCEPLINK

ANKRD6

406

Q9Y2G4
PNSDCLCLGRPLQNR

ARHGEF9

86

O43307
NEGLLACQLLPSIPC

AP4E1

1086

Q9UPM8
LQIPPSLLTCGGCQQ

LMO2

21

P25791
QPLCLPLPVCKQLCT

RANBP2

511

P49792
CLPALCLQTQLLPYL

RAD17

551

O75943
QPTCFLLILPNCQKI

PABIR3

131

Q6P4D5
NNLIPKVCPELCNLT

LRRC69

46

Q6ZNQ3
TNGPILLAQTPICDC

NOL9

591

Q5SY16
DSSILPLSNCPQLQC

OAZ2

6

O95190
PLCLTPLDNACLTNP

NOTCH1

96

P46531
PLILPQELPCDLVCQ

NUDT18

176

Q6ZVK8
TPGQLQCLAGLPCLE

LRRC61

111

Q9BV99
LCQVCLPLLAQDPGG

GPR137

381

Q96N19
CLLAGQPEALSAQCP

JAG2

911

Q9Y219
QSLLACCQLPSRPGI

ASPDH

266

A6ND91
LLQNLLTCGEPPTCS

LRP5

1246

O75197
DDLVCHICLQPLLQP

LNX2

46

Q8N448
HICLQPLLQPLDTPC

LNX2

51

Q8N448
PNVLQCLGLCVETLP

LMTK3

191

Q96Q04
CREDPQGCLLNLLLQ

HMGN2P46

91

Q86SG4
PGAKNCTLCPANLVL

PCSK5

1681

Q92824
ALCLPNICTQPIPLL

PARG

601

Q86W56
NPLICSLQCQAALLP

PDYN

41

P01213
VRCCPCGQTPLSQLL

NFX1

591

Q12986
NAVLCCPPIALRNLI

CD200R1

56

Q8TD46
RDNLGCSCNPSILPI

ENPP1

621

P22413
CLTTQLPELNGCPKQ

HMGXB4

571

Q9UGU5
LGLQACKVQQCIPLP

IQCF5

131

A8MTL0
NLQLPLQFLSRCPSC

NPC1

86

O15118
QLLVCFLLLNSCPGG

RESP18

56

Q5W5W9
NLLPLCCLALLALPA

DHH

6

O43323
CTNSLHLNVVPPVCL

MARF1

251

Q9Y4F3
NPLLEPCGCVGSLQF

MARCHF10

671

Q8NA82
LLNPCQNQGSCRHLP

CELSR3

1986

Q9NYQ7
ICVVCEAPLALQLQP

DZANK1

266

Q9NVP4
QSLGPLPACDLCDQL

GUSBP1

86

Q15486
LGCLIANRPDGNCQP

SCAPER

1061

Q9BY12
TQLKEAQACIPPCGL

SPACA6

116

W5XKT8
ALPPACQLVQVALGC

SPATA2L

141

Q8IUW3
RCSPLGLLVLQNCPG

SSPOP

1721

A2VEC9
LSHQLCQDLPPCQPG

SSPOP

4446

A2VEC9
ETTECNVCLPGNLPL

NXPE3

221

Q969Y0
ENLILDDCGNCVPLP

PLCE1

206

Q9P212
LHALCPGCPLQQSLQ

PRORY

126

Q9H606
CLQDRGLQPPCLQSP

PPARGC1B

226

Q86YN6
RSLLQGDSVQPCPIC

RNF32

116

Q9H0A6
LASPPCNQAPILTCL

SLC9A5

801

Q14940
VPASCGQLLTQLLLC

OCSTAMP

41

Q9BR26
PQAIKCCLADLPQSI

TDRD7

766

Q8NHU6
CQPVLPSPACQLVLH

PMEL

541

P40967
SPLPCLNNGVCKDLV

SVEP1

1236

Q4LDE5
GQLCEVPLCAPNLCQ

NOTCH4

621

Q99466
LPEICTQCPGSVQNL

ATRAID

31

Q6UW56
PLQSLLQRLCSGPCH

CLEC10A

26

Q8IUN9
QCLQDILARGCPTEP

CLCNKA

616

P51800
CCLSLPGQLPLAIRL

C11orf21

91

Q9P2W6
LCLSGQLYLPNIPCT

NDUFV1-DT

96

Q8NBR9
VLCAATCQPPQFQLL

NDUFV1-DT

186

Q8NBR9
QCALKTGNLRCLPLP

RNF223

216

E7ERA6
GKQLCAAPEPQLCLQ

PIH1D2

41

Q8WWB5
PLILCLGNHCSLPQQ

PLCL1

486

Q15111
GLPVLQTQGLQCACP

SSH2

1371

Q76I76
LKCQLPQDPGCTNLL

RREB1

396

Q92766
LEHVLPNPQLLCCDN

SGIP1

621

Q9BQI5
NSLCPGTLCLILLPG

REXO5

731

Q96IC2
RCSQCGILLPLPILN

XAF1

266

Q6GPH4
KAPAQLCEGCPLQSL

TBC1D1

381

Q86TI0
ALLLGCLCQESPINV

WAPL

1126

Q7Z5K2
GLNCEPEQLPIDRCL

STAB2

2161

Q8WWQ8
LCLQQGQLCEPLPSL

NAPRT

476

Q6XQN6
CVCALPPQLRGPLTQ

PPP1R3F

751

Q6ZSY5
GLLHQELSCPLCLQL

TRIM72

6

Q6ZMU5
LCQPQVLPNLNLDCR

RPAP1

1186

Q9BWH6
SCGGQSPPVLCQLLD

nan

426

Q3C1V9
SDPLLELCQCPLCQL

ZNF821

111

O75541
LPHCQQTGTLKNCLP

TEX26

111

Q8N6G2
LQGLKQEVTCLCPSP

WDR3

61

Q9UNX4
CLQDLDLNLCTPQPA

ZNF683

76

Q8IZ20
LGLCLLQNELCPITL

UBR5

2536

O95071
LLLQNDPCLLPEVCL

ZC3HAV1L

156

Q96H79
QVLQCQPAACQALPL

LRRC14

11

Q15048