Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesscell cycle process

HORMAD2 NCAPD3 ATR HUS1 BTBD18 RTTN APEX1 MED1 ZNF365 ZNF503 FANCA ESCO2 CCNG2 MEI4 NEK1 LATS1 KLHDC3 RAD1 SVIL TTL CDC25B ESPL1 PLK4 DYNC1H1 HTT TBCE CDK6

2.50e-06144114527GO:0022402
GeneOntologyCellularComponentmicrotubule organizing center

HORMAD2 FLII RTTN APEX1 ZNF365 CEP350 EFHC2 DNAAF2 NEK1 LATS1 UBN1 NLRC5 CDC25B ESPL1 PLK4 DYNC1H1 HTT CDK6

8.27e-0591914718GO:0005815
GeneOntologyCellularComponentcentrosome

HORMAD2 FLII RTTN APEX1 ZNF365 CEP350 NEK1 LATS1 UBN1 NLRC5 CDC25B ESPL1 PLK4 DYNC1H1 CDK6

3.54e-0477014715GO:0005813
GeneOntologyCellularComponentcondensed nuclear chromosome

HORMAD2 NCAPD3 HUS1 MEI4 RAD1

4.60e-04911475GO:0000794
GeneOntologyCellularComponentcheckpoint clamp complex

HUS1 RAD1

4.84e-0451472GO:0030896
GeneOntologyCellularComponentXY body

ATR ESCO2 PLK4

5.44e-04231473GO:0001741
HumanPhenoAbnormality of the musculature of the limbs

GPHN SH3TC2 NCAPD3 LRSAM1 CAPN1 KAT6A AK9 REV3L SLC1A2 LYST ITPR1 NEK1 SBF1 IGHMBP2 PACS2 KIF5A FAR1 DYNC1H1 TBCE

1.64e-056585319HP:0009127
MousePhenoinduced chromosome breakage

ATR HUS1 FANCA FANCG

5.68e-05251204MP:0004030
MousePhenoabnormal apoptosis

HORMAD2 PRAMEF33 ILF3 PRAMEF10 ATR HUS1 ABHD2 BTBD18 BAX ARFGEF1 APEX1 REV3L MED1 FBXO47 CCDC159 FANCA DNAAF2 UNC5A MEI4 PACS2 FAR1 PLK4 DYNC1H1 HTT CDK6 MPI

6.60e-05135312026MP:0001648
MousePhenoabsent gametes

HORMAD2 PRAMEF33 PRAMEF10 ATR BTBD18 BAX FBXO47 MEI4 SBF1 FAR1

7.06e-0525612010MP:0001117
MousePhenoabnormal programmed cell death

HORMAD2 PRAMEF33 ILF3 PRAMEF10 ATR HUS1 ABHD2 BTBD18 BAX ARFGEF1 APEX1 REV3L MED1 FBXO47 CCDC159 FANCA DNAAF2 UNC5A MEI4 PACS2 FAR1 PLK4 DYNC1H1 HTT CDK6 MPI

7.19e-05136012026MP:0014355
MousePhenodecreased germ cell number

HORMAD2 PRAMEF33 PRAMEF10 ATR CES5A HSPA4L BTBD18 BAX APOB FBXO47 FANCA MEI4 SBF1 TAF7L FAR1 SPAG17 PLK4

7.73e-0568712017MP:0002209
MousePhenodecreased testis weight

HORMAD2 PRAMEF33 PRAMEF10 ATR BTBD18 BAX FANCA MEI4 FANCG TAF7L FAR1 PLK4

7.98e-0537012012MP:0004852
MousePhenoabnormal gametogenesis

HORMAD2 PRAMEF33 PRAMEF10 ATR CES5A HSPA4L BTBD18 BAX APOB PKDREJ FBXO47 CCDC159 FANCA MEI4 FANCG NEK1 SBF1 TAF7L FAR1 SPAG17 CDC25B PLK4

1.01e-04107012022MP:0001929
MousePhenospontaneous chromosome breakage

ATR REV3L FANCA FANCG

1.04e-04291204MP:0004029
MousePhenoincreased apoptosis

PRAMEF33 ILF3 PRAMEF10 ATR HUS1 ABHD2 BTBD18 BAX ARFGEF1 APEX1 REV3L FBXO47 CCDC159 FANCA DNAAF2 MEI4 FAR1 DYNC1H1 HTT CDK6 MPI

1.24e-04100812021MP:0006042
MousePhenoincreased motor neuron number

GPHN BAX UNC5A

1.28e-04121203MP:0005192
MousePhenoabnormal testis weight

HORMAD2 PRAMEF33 PRAMEF10 ATR BTBD18 BAX FANCA MEI4 FANCG TAF7L FAR1 PLK4

1.34e-0439112012MP:0004850
MousePhenoincreased cell death

PRAMEF33 ILF3 PRAMEF10 ATR HUS1 ABHD2 BTBD18 BAX ARFGEF1 APEX1 REV3L FBXO47 CCDC159 FANCA DNAAF2 MEI4 FAR1 DYNC1H1 HTT CDK6 MPI

1.44e-04101912021MP:0012556
MousePhenoabnormal cell cycle

HORMAD2 ATR HUS1 BAX MED1 FBXO47 FANCA ESCO2 MEI4 LATS1 CDC25B GCN1 PLK4 DYNC1H1

1.46e-0452012014MP:0003077
MousePhenochromosome breakage

ATR HUS1 REV3L FANCA FANCG

1.88e-04621205MP:0004028
MousePhenoazoospermia

HORMAD2 PRAMEF33 PRAMEF10 BTBD18 BAX FBXO47 MEI4 SBF1 FAR1

2.52e-042441209MP:0005159
MousePhenoabnormal spermatogenesis

HORMAD2 PRAMEF33 PRAMEF10 CES5A HSPA4L BTBD18 BAX APOB PKDREJ FBXO47 CCDC159 FANCA MEI4 FANCG NEK1 SBF1 TAF7L FAR1 SPAG17

2.64e-0491012019MP:0001156
MousePhenomotor neuron degeneration

GPHN IGHMBP2 DYNC1H1 TBCE

3.04e-04381204MP:0000938
MousePhenoabnormal motor neuron morphology

GPHN BAX UNC5A IGHMBP2 KIF5A DYNC1H1 TBCE

3.21e-041511207MP:0000937
MousePhenoembryonic lethality between implantation and placentation

NCAPD3 DNAJC13 ATR APEX1 REV3L MED1 PIKFYVE DNAAF2 ZFR ESPL1 DDX24 PLK4 DYNC1H1 HTT

3.43e-0456512014MP:0009850
MousePhenodecreased male germ cell number

HORMAD2 PRAMEF33 PRAMEF10 CES5A HSPA4L BTBD18 BAX APOB FBXO47 MEI4 SBF1 TAF7L FAR1 SPAG17 PLK4

3.77e-0464012015MP:0004901
MousePhenoembryonic lethality between implantation and placentation, complete penetrance

NCAPD3 DNAJC13 ATR APEX1 REV3L PIKFYVE DNAAF2 ZFR ESPL1 DDX24 PLK4 DYNC1H1 HTT

4.01e-0450612013MP:0011095
MousePhenoabnormal germ cell morphology

HORMAD2 PRAMEF33 PRAMEF10 ATR CES5A HSPA4L BTBD18 BAX APOB FBXO47 CCDC159 FANCA MEI4 SBF1 TAF7L FAR1 SPAG17 CDC25B PLK4

4.30e-0494612019MP:0002208
MousePhenoincreased mature ovarian follicle number

ABHD2 BAX

4.34e-0441202MP:0008870
MousePhenohippocampus pyramidal cell degeneration

TRIB2 SLC1A2

4.34e-0441202MP:0010014
MousePhenoabnormal foam cell morphology

HORMAD2 PRAMEF33 PRAMEF10 ATR CES5A HSPA4L BTBD18 BAX APOB FBXO47 CCDC159 FANCA MEI4 SBF1 TAF7L FAR1 SPAG17 CDC25B PLK4

4.77e-0495412019MP:0009840
MousePhenoabnormal mature ovarian follicle morphology

ABHD2 BAX FANCA LATS1 CDK6

5.49e-04781205MP:0009364
MousePhenoabnormal ovarian folliculogenesis

ATR ABHD2 BAX FANCA FANCG LATS1

5.82e-041201206MP:0001130
MousePhenoabnormal spinal cord morphology

GPHN ATR BAX PIKFYVE UNC5A IGHMBP2 KIF5A DYNC1H1 TBCE

6.52e-042781209MP:0000955
DomainARM-type_fold

USP34 NCAPD3 DNAJC13 CAND2 ATR RTTN ARFGEF1 APOB BTAF1 HEATR1 LYST ITPR1 FOCAD UPF2 IFRD2 UTP20 GCN1 UNC79 HTT

1.21e-1133914219IPR016024
DomainHEAT

NCAPD3 CAND2 ATR BTAF1 HEATR1 UTP20 GCN1 HTT

2.67e-09481428PF02985
DomainHEAT

NCAPD3 CAND2 ATR BTAF1 HEATR1 UTP20 GCN1 HTT

1.27e-08581428IPR000357
DomainHEAT_REPEAT

NCAPD3 CAND2 ATR BTAF1 HEATR1 UTP20 GCN1 HTT

5.81e-08701428PS50077
Domain-

NCAPD3 DNAJC13 CAND2 ATR RTTN ARFGEF1 BTAF1 HEATR1 IFRD2 UTP20 GCN1 HTT

1.32e-07222142121.25.10.10
DomainARM-like

NCAPD3 DNAJC13 CAND2 ATR RTTN ARFGEF1 BTAF1 HEATR1 TAF7L IFRD2 UTP20 GCN1 HTT

1.50e-0727014213IPR011989
PathwayBIOCARTA_ATRBRCA_PATHWAY

ATR HUS1 FANCA FANCG RAD1

2.12e-07191045MM1478
PathwayBIOCARTA_ATRBRCA_PATHWAY

ATR HUS1 FANCA FANCG RAD1

4.73e-07221045M9703
PathwayPID_FANCONI_PATHWAY

ATR HUS1 FANCA FANCG RAD1

2.38e-05471045M1
PathwayWP_DNA_REPAIR_PATHWAYS_FULL_NETWORK

ATR POLM APEX1 REV3L FANCA FANCG GTF2H2

2.92e-051201047M40049
PathwayWP_ATR_SIGNALING

ATR HUS1 RAD1

6.17e-05111043M39507
PathwayKEGG_MEDICUS_REFERENCE_ATR_SIGNALING

ATR HUS1 RAD1

8.18e-05121043M47841
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MTA2 USP34 FLII RTTN KAT6A HECTD4 BTAF1 REV3L LYST ZNF503 FANCA FOCAD PIKFYVE SH3PXD2B UBN1 SBF1 IFRD2 NLRC5 ESPL1 GCN1 SMURF2 CRAMP1 DYNC1H1 HTT

6.51e-1111051492435748872
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

DIP2B FLII NCAPD3 DNAJC13 ILF3 ATR BTAF1 ARHGAP39 MED1 EIF2D LATS1 UBN1 FAM13A SVIL ZBTB21 PACS2 UTP20 ESPL1 DDX24

1.04e-097741491915302935
Pubmed

Defining the membrane proteome of NK cells.

MTA2 DIP2B NCAPD3 DNAJC13 ILF3 BAX DGKA LRRC59 HEATR1 MED1 ANKRD27 TUFM ITPR1 CEP350 MED15 PIGT FAM120A IGHMBP2 KIF5A DDX24 GCN1 DYNC1H1

6.02e-0911681492219946888
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

MTA2 FLII DNAJC13 ILF3 LRSAM1 CAPN1 EXOSC3 HEATR1 ANKRD27 TUFM ASAP1 EIF2D FAM120A UBN1 SBF1 UPF2 RPF2 UTP20 ZFR FAR1 DDX24 GCN1 DYNC1H1

1.76e-0813531492329467282
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

MTA2 GPHN ILF3 LRRC59 HEATR1 MED1 TUFM ASAP1 ESCO2 DNAAF2 SH3PXD2B RPF2 CRYBG3 HDGFL2

1.82e-084721491438943005
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

FLII NCAPD3 DNAJC13 ATR BTAF1 MED1 TUFM SBF1 UTP20 GCN1

1.89e-082021491033005030
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

DIP2B NCAPD3 ATR DGKA BTAF1 ANKRD27 DENND3 TUFM ITPR1 FANCA EIF2D FAM120A SBF1 UPF2 CRYBG3 CDC25B

2.27e-086501491638777146
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

MTA2 FLII NCAPD3 DNAJC13 KAT6A EXOSC3 HEATR1 MED1 FAM120A UPF2 IGHMBP2 UTP20 ZFR FAR1 ESPL1 DDX24 GCN1

3.18e-087591491735915203
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

GPHN DIP2B ARHGEF17 LYST ANKRD27 CEP350 NEK1 SH3PXD2B LATS1 FAM13A SBF1 SVIL ZBTB21 MIEF1 CRYBG3 CDC25B PLK4 DOP1A

3.46e-088611491836931259
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

GPHN DIP2B FLII DLGAP1 DNAJC13 ILF3 NHSL2 HECTD4 ARHGAP39 SLC1A2 SH3PXD2B FAM120A SBF1 SVIL ZBTB21 ZFR KIF5A UNC79 DYNC1H1

3.48e-089631491928671696
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

USP34 DNAJC13 BTBD18 EXOSC3 MUC16 APEX1 APOB BTAF1 TUFM SBF1 ZFR CDC25B DOP1A

3.66e-084201491328065597
Pubmed

ATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway function.

ATR FANCA FANCG

7.71e-083149319109555
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

FLII DNAJC13 ILF3 CAPN1 EXOSC3 LRRC59 MED1 CEP350 SH3PXD2B FAM120A SBF1 UPF2 ZFR ESPL1 DDX24 GCN1

9.93e-087241491636232890
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

MTA2 DIP2B DNAJC13 ILF3 HECTD4 APEX1 LRRC59 ARHGAP39 MED1 TUFM TRMT10C SBF1 UPF2 RPF2 USP12 ALB DDX24 GCN1 DYNC1H1

2.11e-0710821491938697112
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

MTA2 GPHN FLII DLGAP1 DNAJC13 ILF3 HSPA4L LRRC59 ARHGAP39 ARHGEF17 SLC1A2 TUFM ASAP1 FAM120A SBF1 UPF2 SVIL PLXNA4 PACS2 ALB PLPPR2 DYNC1H1

2.12e-0714311492237142655
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

MTA2 USP34 NCAPD3 CAND2 HSPA4L EXOSC3 LRRC59 BTAF1 HEATR1 COG3 TUFM ITPR1 TRMT10C PIGT FAM120A UBN1 RPF2 ZFR FAR1 DDX24 GCN1 DYNC1H1

2.36e-0714401492230833792
Pubmed

Nucleolar proteome dynamics.

NCAPD3 ILF3 ATR APEX1 TUFM GTF2H2 RPF2 UTP20 ZFR DDX24 GCN1 DYNC1H1

2.87e-074191491215635413
Pubmed

Differential Dynamics of ATR-Mediated Checkpoint Regulators.

ATR HUS1 RAD1

3.07e-074149320847938
Pubmed

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

NCAPD3 ARFGEF1 BTAF1 ITPR1 FANCA FAR1 HTT

3.45e-07104149731240132
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

FLII NCAPD3 ILF3 CAND2 CAPN1 EXOSC3 HEATR1 TUFM UPF2 UTP20 ZFR DDX24 GCN1 DYNC1H1 CDK6

4.05e-077041491529955894
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

DIP2B DNAJC13 ABHD2 CAPN1 KAT6A HECTD4 EXOSC3 BTAF1 ARHGAP39 COG3 SEC22A TASOR2 CCNG2 GTF2H2 FAM120A FAM13A RPF2 NLRC5 SMURF2 CRAMP1 HTT DOP1A

4.15e-0714891492228611215
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

MTA2 GPHN HEATR1 MED1 TUFM MED15 NEK1 SH3PXD2B LATS1 ZFR GCN1 DYNC1H1 HTT

7.78e-075491491338280479
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

MTA2 USP34 CAPN1 HEATR1 TUFM TASOR2 FAM120A SBF1 RPF2 UTP20 ZFR DDX24 GCN1 DYNC1H1

9.35e-076531491422586326
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

MTA2 GPHN USP34 DIP2B NCAPD3 CAND2 HSPA4L NAP1L5 HEATR1 TRMT10C FAM120A SBF1 KIF5A FAR1 CDC25B ESPL1 GCN1

1.05e-069741491728675297
Pubmed

Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin.

KIF5A DYNC1H1 HTT

1.53e-066149319525941
Pubmed

SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9-Rad1-Hus1 checkpoint clamp.

HUS1 APEX1 RAD1

1.53e-066149326063178
Pubmed

Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress.

HUS1 BAX RAD1

1.53e-066149310921903
Pubmed

Knockdown of mu-calpain in Fanconi anemia, FA-A, cells by siRNA restores alphaII spectrin levels and corrects chromosomal instability and defective DNA interstrand cross-link repair.

CAPN1 FANCA FANCG

1.53e-066149320518497
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

MTA2 FLII ILF3 CAPN1 EXOSC3 LRRC59 HEATR1 TUFM TASOR2 TRMT10C FAM120A UPF2 SVIL RPF2 UTP20 ZFR ALB DDX24 DYNC1H1

1.98e-0612571491936526897
Pubmed

Charcot-Marie-Tooth Hereditary Neuropathy Overview

SH3TC2 LRSAM1 SBF1 IGHMBP2 DYNC1H1

1.99e-0648149520301532
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

MTA2 FLII ILF3 LRRC59 BTAF1 HEATR1 TUFM CEP350 SVIL RPF2 ZBTB21 UTP20 ZFR ALB FAR1 GCN1 DYNC1H1

2.07e-0610241491724711643
Pubmed

Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.

ATR HUS1 MED1 FANCA FANCG RAD1

2.42e-0689149618950845
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

MTA2 FLII NCAPD3 ILF3 ATR HSPA4L APOB LRRC59 HEATR1 TUFM TRMT10C FAM120A RPF2 UTP20 ZFR KIF3C FAR1 DDX24 GCN1 DYNC1H1

3.19e-0614251492030948266
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

ILF3 HSPA4L NHSL2 DGKA APOB LRRC59 HEATR1 LYST TUFM TASOR2 LATS1 RPF2 ZBTB21 PLXNA4 ZFR KIF5A SPAG17 HDGFL2 SMURF2 DOP1A

3.81e-0614421492035575683
Pubmed

ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis.

ATR HUS1 RAD1

4.25e-068149318162465
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

USP34 NCAPD3 ILF3 ATR HUS1 MED1 FANCA MED15 FANCG RAD1 ZFR

4.47e-064531491129656893
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

DIP2B FLII ILF3 HSPA4L BAX LRRC59 HEATR1 RMDN2 TUFM ITPR1 PIKFYVE TRMT10C FAM120A UPF2 RPF2 MIEF1 ZFR CRYBG3 ESPL1 DDX24

6.57e-0614961492032877691
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

MTA2 FLII ILF3 KBTBD8 APOB LRRC59 MED1 TUFM ESCO2 CEP350 TRMT10C GTF2H2 FAM120A UPF2 SVIL USP12 MIEF1 GCN1 DYNC1H1

6.88e-0613711491936244648
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

USP34 DNAJC13 BAX ARFGEF1 MUC16 APOB TUFM TASOR2 CEP350 MIEF1 ZFR ALB GCN1 DYNC1H1

6.93e-067771491435844135
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

FLII ILF3 HSPA4L CAPN1 BAX APEX1 LRRC59 MED1 TUFM MED15 EIF2D LATS1 FAM120A IGHMBP2 SVIL DDX24 GCN1 DYNC1H1

7.07e-0612471491827684187
Pubmed

A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.

USP34 ATR MED1

9.05e-0610149317478428
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

HUS1 HSPA4L NAP1L5 LRRC59 HEATR1 TUFM EIF2D KLHDC3 RPF2 ZBTB21 FAR1 CDC25B DDX24 GCN1 UNC79 HDGFL2 DYNC1H1 CDK6

1.05e-0512841491817353931
Pubmed

Activator-Mediator binding regulates Mediator-cofactor interactions.

MED1 MED15 GCN1

1.24e-0511149320534441
Pubmed

Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.

NLRP11 ATR BAX REV3L ESCO2 RAD1 CDK6

1.29e-05179149719074885
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

NCAPD3 CAND2 HSPA4L BAX ARFGEF1 LRRC59 BTAF1 HEATR1 TUFM FANCA UTP20 FAR1 ESPL1 GCN1 DYNC1H1

1.39e-059421491531073040
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

MTA2 ILF3 HSPA4L LRRC59 HEATR1 ANKRD27 TUFM TRMT10C GTF2H2 FAM120A UPF2 IFRD2 RPF2 ALB FAR1 DDX24 GCN1 DYNC1H1

1.49e-0513181491830463901
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

MTA2 GPHN DNAJC13 CAND2 HEATR1 MED1 MED15 EFHC2 DNAAF2 NEK1 PIGT ZBTB21 KIF3C CDC25B DDX24 GCN1 DYNC1H1 TBCE

1.53e-0513211491827173435
Pubmed

ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.

MTA2 FLII HEATR1 TUFM TASOR2 FANCG EIF2D GTF2H2 ZFR ALB FAR1 DDX24

1.71e-056241491233729478
Pubmed

A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers.

FLII NCAPD3 DDX24 GCN1 DYNC1H1 CDK6

1.72e-05125149621654808
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

USP34 PRAMEF33 PRAMEF10 CAND2 ABHD2 KBTBD8 DGKA APOB HEATR1 ASAP1 ITPR1 ESCO2 SH3PXD2B KLHDC3 ESPL1 CDK6

1.80e-0510841491611544199
Pubmed

A cytoplasmic serine protein kinase binds and may regulate the Fanconi anemia protein FANCA.

FANCA FANCG

1.82e-052149211739169
Pubmed

Regulation of the glutamate transporter EAAT2 by PIKfyve.

SLC1A2 PIKFYVE

1.82e-052149219910676
Pubmed

The fanconi anemia proteins FANCA and FANCG stabilize each other and promote the nuclear accumulation of the Fanconi anemia complex.

FANCA FANCG

1.82e-052149211050007
Pubmed

Functional analysis of the putative peroxidase domain of FANCA, the Fanconi anemia complementation group A protein.

FANCA FANCG

1.82e-052149211161829
Pubmed

Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells.

FANCA FANCG

1.82e-052149224799500
Pubmed

Clinical and Genetic Features of Patients With Fanconi Anemia in Lebanon and Report on Novel Mutations in the FANCA and FANCG Genes.

FANCA FANCG

1.82e-052149232947577
Pubmed

FANCA Promotes DNA Double-Strand Break Repair by Catalyzing Single-Strand Annealing and Strand Exchange.

FANCA FANCG

1.82e-052149230057198
Pubmed

Chemosensitizing tumor cells by targeting the Fanconi anemia pathway with an adenovirus overexpressing dominant-negative FANCA.

FANCA FANCG

1.82e-052149215192709
Pubmed

Evidence for complete epistasis of null mutations in murine Fanconi anemia genes Fanca and Fancg.

FANCA FANCG

1.82e-052149222036606
Pubmed

Characterization, expression and complex formation of the murine Fanconi anaemia gene product Fancg.

FANCA FANCG

1.82e-052149211918676
Pubmed

Knockdown of REV3 synergizes with ATR inhibition to promote apoptosis induced by cisplatin in lung cancer cells.

ATR REV3L

1.82e-052149228075014
Pubmed

Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicity.

CAPN1 HTT

1.82e-052149219036965
Pubmed

Oxidative stress/damage induces multimerization and interaction of Fanconi anemia proteins.

FANCA FANCG

1.82e-052149215138265
Pubmed

Deubiquitinating Enzyme USP12 Regulates the Pro-Apoptosis Protein Bax.

BAX USP12

1.82e-052149236361894
Pubmed

Investigation of Fanconi anemia protein interactions by yeast two-hybrid analysis.

FANCA FANCG

1.82e-052149210652215
Pubmed

Resistance to mitomycin C requires direct interaction between the Fanconi anemia proteins FANCA and FANCG in the nucleus through an arginine-rich domain.

FANCA FANCG

1.82e-052149210567393
Pubmed

Novel mutations of the FANCG gene causing alternative splicing in Japanese Fanconi anemia.

FANCA FANCG

1.82e-052149210807541
Pubmed

Multiple TPR motifs characterize the Fanconi anemia FANCG protein.

FANCA FANCG

1.82e-052149214697762
Pubmed

FANCA and FANCG are the major Fanconi anemia genes in the Korean population.

FANCA FANCG

1.82e-052149223067021
Pubmed

Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation.

SLC1A2 HTT

1.82e-052149212135980
Pubmed

Necessity of inositol (1,4,5)-trisphosphate receptor 1 and mu-calpain in NO-induced osteoclast motility.

CAPN1 ITPR1

1.82e-052149217690304
Pubmed

A physical complex of the Fanconi anemia proteins FANCG/XRCC9 and FANCA.

FANCA FANCG

1.82e-052149210468606
Pubmed

Rare germinal unequal crossing-over leading to recombinant gene formation and gene duplication in Arabidopsis thaliana.

FANCA FANCG

1.82e-052149210468603
Pubmed

Human hRad1 but not hRad9 protects hHus1 from ubiquitin-proteasomal degradation.

HUS1 RAD1

1.82e-052149215122316
Pubmed

Bax and calpain mediate excitotoxic oligodendrocyte death induced by activation of both AMPA and kainate receptors.

CAPN1 BAX

1.82e-052149221414921
Pubmed

Molecular characterization of three novel Fanconi anemia mutations in Israeli Arabs.

FANCA FANCG

1.82e-052149215059067
Pubmed

Fanconi anemia protein, FANCG, is a phosphoprotein and is upregulated with FANCA after TNF-alpha treatment.

FANCA FANCG

1.82e-052149211181053
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

EXOSC3 DGKA REV3L ARHGEF17 TUFM FANCA FOCAD RANBP3L PLXNA4 UTP20 ALB DYNC1H1 FBXO34

1.84e-057361491329676528
Pubmed

A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.

ATR HUS1 RAD1

2.14e-0513149321659603
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

GPHN FLII CAPN1 EXOSC3 HEATR1 ZNF503 CEP350 PIGT LATS1 IGHMBP2 UTP20 ZFR GCN1

2.37e-057541491333060197
Pubmed

Identification of host proteins required for HIV infection through a functional genomic screen.

FLII DLGAP1 EXOSC3 HEATR1 COG3 EFHC2 IGHMBP2 KIF3C

2.43e-05272149818187620
Pubmed

Genetic and physical delineation of the region overlapping the progressive motor neuropathy (pmn) locus on mouse chromosome 13.

HEATR1 LYST TBCE

2.71e-0514149311472062
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

MTA2 ILF3 LRRC59 TUFM ASAP1 FAM120A KLHDC3 RPF2 UTP20 ZFR DDX24 GCN1

2.74e-056551491235819319
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

NCAPD3 DNAJC13 ILF3 HEATR1 UPF2 RPF2 GCN1

2.81e-05202149724639526
Pubmed

Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.

POLM APEX1 REV3L FANCA FANCG

3.17e-0584149519237606
Pubmed

Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.

ATR HSPA4L BTAF1 FAM120A UTP20 ZFR GCN1 HTT

3.38e-05285149832838362
Pubmed

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

DIP2B DLGAP1 ARHGAP39 PIKFYVE SH3PXD2B LATS1 FAR1

4.56e-05218149733378226
Pubmed

Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.

NCAPD3 ILF3 LRRC59 TUFM SH3PXD2B UPF2 IGHMBP2 RPF2 FAR1 DDX24

5.01e-054861491030940648
Pubmed

Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation.

ITPR1 ART3 DYNC1H1

5.01e-0517149320395553
Pubmed

ATG5 is required for B cell polarization and presentation of particulate antigens.

MTA2 DIP2B MED1 TUFM ITPR1 MED15 EIF2D GTF2H2 FAM120A RPF2 ALB GCN1

5.27e-057011491230196744
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

MTA2 GPHN USP34 FLII HSPA4L LRSAM1 CAPN1 NAP1L5 APEX1 XPNPEP1 COG3 TUFM ZNF503 GCN1 HDGFL2 DYNC1H1 HTT TBCE

5.42e-0514551491822863883
Pubmed

Crystal structure of the human rad9-hus1-rad1 clamp.

HUS1 RAD1

5.45e-053149219464297
Pubmed

Phosphorylation of fanconi anemia (FA) complementation group G protein, FANCG, at serine 7 is important for function of the FA pathway.

FANCA FANCG

5.45e-053149215299017
Pubmed

Fanconi anemia group A and C double-mutant mice: functional evidence for a multi-protein Fanconi anemia complex.

FANCA FANCG

5.45e-053149212135664
Pubmed

Iron induces B cell pyroptosis through Tom20-Bax-caspase-gasdermin E signaling to promote inflammation post-spinal cord injury.

BAX GSDME

5.45e-053149237480037
Pubmed

Reconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complex.

HUS1 RAD1

5.45e-053149211340080
Pubmed

Physical interactions among human checkpoint control proteins HUS1p, RAD1p, and RAD9p, and implications for the regulation of cell cycle progression.

HUS1 RAD1

5.45e-053149210777662
Pubmed

The Rad9 protein enhances survival and promotes DNA repair following exposure to ionizing radiation.

HUS1 RAD1

5.45e-053149216814252
Pubmed

Carboxy terminal region of the Fanconi anemia protein, FANCG/XRCC9, is required for functional activity.

FANCA FANCG

5.45e-053149210961856
Pubmed

Tri-cistronic cloning, overexpression and purification of human Rad9, Rad1, Hus1 protein complex.

HUS1 RAD1

5.45e-053149217493829
InteractionSCN2B interactions

CAND2 ATR HUS1 SPPL3 HEATR1 COG3 FOCAD GSDME UTP20 GCN1

1.63e-099514510int:SCN2B
InteractionNPTN interactions

CAND2 ATR ARFGEF1 BTAF1 HEATR1 COG3 FANCA FOCAD PIKFYVE FANCG UTP20 GCN1 HTT DOP1A

1.42e-0827814514int:NPTN
InteractionYWHAH interactions

DIP2B DLGAP1 ILF3 NHSL2 HECTD4 SPPL3 MED1 ARHGEF17 LYST ANKRD27 CEP350 NEK1 SH3PXD2B LATS1 FAM13A SBF1 SVIL ZBTB21 USP12 MIEF1 PACS2 KIF5A CRYBG3 CDC25B PLK4 HTT DOP1A

1.92e-08110214527int:YWHAH
InteractionYWHAQ interactions

DLGAP1 ILF3 HUS1 CAPN1 HECTD4 BAX MED1 LYST CEP350 NEK1 LATS1 FAM13A SBF1 SVIL ZBTB21 MIEF1 PACS2 ALB KIF5A CDC25B DDX24 GCN1 UNC79 PLK4 DYNC1H1 HTT DOP1A

2.59e-08111814527int:YWHAQ
InteractionTOP3B interactions

MTA2 USP34 FLII RTTN KAT6A HECTD4 APOB BTAF1 REV3L LYST TUFM ZNF503 FANCA FOCAD PIKFYVE SH3PXD2B FAM120A UBN1 SBF1 UPF2 SVIL IFRD2 NLRC5 ZFR ESPL1 GCN1 SMURF2 CRAMP1 DYNC1H1 HTT

1.62e-07147014530int:TOP3B
InteractionOPALIN interactions

NCAPD3 CAND2 ATR RTTN ARFGEF1 BTAF1 HEATR1 SBF1 USP12 UTP20 GCN1

3.45e-0720914511int:OPALIN
InteractionNPY2R interactions

CAND2 ARFGEF1 APEX1 BTAF1 FANCA GCN1 HTT

4.71e-07661457int:NPY2R
InteractionYWHAB interactions

DLGAP1 NCAPD3 KAT6A HECTD4 BAX RMDN2 ARHGEF17 LYST CEP350 NEK1 LATS1 FAM13A SVIL ZBTB21 USP12 MIEF1 PACS2 KIF5A CDC25B DDX24 PLK4 DYNC1H1 HTT

9.59e-07101414523int:YWHAB
InteractionGPR17 interactions

CAND2 ATR SPPL3 ARFGEF1 BTAF1 HEATR1 COG3 FANCA FANCG UTP20 HTT DOP1A

1.00e-0628314512int:GPR17
InteractionLRRC31 interactions

FLII NCAPD3 DNAJC13 ATR BTAF1 MED1 TUFM SBF1 UTP20 GCN1

2.38e-0620514510int:LRRC31
InteractionSFN interactions

BAX LRRC59 ARHGEF17 LYST CEP350 PIGT LATS1 FAM13A SVIL ZBTB21 MIEF1 PACS2 CRYBG3 CDC25B DDX24 PLK4 HTT DOP1A

2.51e-0669214518int:SFN
InteractionCTDP1 interactions

NCAPD3 ARFGEF1 APEX1 BTAF1 MED1 ITPR1 FANCA MED15 FAR1 HTT

2.60e-0620714510int:CTDP1
InteractionBCL2L14 interactions

MTA2 NCAPD3 CAND2 BAX HEATR1 TUFM GCN1 HDGFL2

3.85e-061271458int:BCL2L14
InteractionGPR182 interactions

NCAPD3 CAND2 ATR SPPL3 ARFGEF1 BTAF1 HEATR1 COG3 FANCA FOCAD FANCG UTP20 GCN1 HTT

5.40e-0645514514int:GPR182
InteractionSPTAN1 interactions

GPHN DLGAP1 NCAPD3 CAPN1 APOB FANCA FANCG GSDME LATS1 FAM120A SVIL ALB DDX24 HTT

1.43e-0549614514int:SPTAN1
InteractionCCDC8 interactions

FLII ILF3 APOB LRRC59 BTAF1 HEATR1 TUFM CEP350 SVIL ZBTB21 UTP20 ZFR ALB FAR1 GCN1 DYNC1H1

2.08e-0565614516int:CCDC8
InteractionYWHAG interactions

GPHN DLGAP1 NHSL2 HECTD4 ARHGEF17 LYST CEP350 NEK1 LATS1 FAM13A SBF1 SVIL ZBTB21 USP12 MIEF1 PACS2 ALB KIF5A CDC25B PLK4 DYNC1H1 HTT DOP1A

2.90e-05124814523int:YWHAG
InteractionFAAP24 interactions

ATR APEX1 FANCA FANCG

3.40e-05261454int:FAAP24
InteractionGPR45 interactions

NCAPD3 ATR SPPL3 ARFGEF1 BTAF1 HEATR1 COG3 FANCA GSDME GCN1

6.46e-0530014510int:GPR45
InteractionYWHAZ interactions

DLGAP1 NCAPD3 KAT6A HECTD4 LYST ANKRD27 TUFM ITPR1 NEK1 LATS1 FAM13A SBF1 SVIL ZBTB21 MIEF1 PACS2 KIF5A CDC25B DDX24 PLK4 DYNC1H1 HTT SENP7

6.79e-05131914523int:YWHAZ
InteractionMUTYH interactions

ATR HUS1 LRSAM1 APEX1

6.95e-05311454int:MUTYH
InteractionOPRM1 interactions

ATR SPPL3 COG3 SEC22A FANCA GCN1 HTT

8.34e-051441457int:OPRM1
InteractionRAD9B interactions

HUS1 APEX1 RAD1

9.90e-05131453int:RAD9B
InteractionCOMTD1 interactions

NCAPD3 APEX1 BTAF1 HEATR1 COG3 GSDME UPF2 GCN1

1.02e-042001458int:COMTD1
InteractionP2RY10 interactions

CAND2 SPPL3 HEATR1 COG3 FANCA MPI

1.18e-041061456int:P2RY10
InteractionCD6 interactions

DIP2B NCAPD3 KBTBD8 XPNPEP1 GTF2H2 SBF1 USP12

1.27e-041541457int:CD6
InteractionTP53BP1 interactions

MTA2 USP34 ILF3 ATR HUS1 SPPL3 APEX1 MED1 MED15 NEK1 RAD1 ZFR SMURF2

1.29e-0453314513int:TP53BP1
InteractionBTNL9 interactions

USP34 NCAPD3 CAND2 BTAF1 FOCAD GSDME SBF1

1.38e-041561457int:BTNL9
InteractionMEN1 interactions

MTA2 NCAPD3 DNAJC13 ILF3 EXOSC3 ARFGEF1 APEX1 BTAF1 HEATR1 MED1 ARHGEF17 FANCA FAM120A UPF2 RPF2 UTP20 ZFR FAR1 DDX24

1.50e-04102914519int:MEN1
InteractionSIRT6 interactions

MTA2 ILF3 HUS1 HSPA4L HECTD4 EXOSC3 APEX1 MED1 TASOR2 ITPR1 FANCA SBF1 RAD1 ESPL1

1.80e-0462814514int:SIRT6
GeneFamilyCheckpoint clamp complex

HUS1 RAD1

7.00e-0538821339
GeneFamilyGelsolin/villins

FLII SVIL

6.43e-048882950
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

USP34 DNAJC13 ATR KAT6A ARFGEF1 BTAF1 REV3L MED1 ITPR1 CEP350 PIKFYVE NEK1 UPF2 USP12 UTP20 CRYBG3 SMURF2 FOXD1

1.90e-0685614918M4500
CoexpressionPATIL_LIVER_CANCER

ILF3 CAPN1 ARFGEF1 ARHGAP39 ANKRD27 ASAP1 ESCO2 FANCG SH3PXD2B RAD1 CDC25B ESPL1 PLK4 DYNC1H1 TBCE

5.76e-0666014915M1195
CoexpressionPUJANA_BRCA2_PCC_NETWORK

ILF3 ATR BAX BTAF1 FANCA PIKFYVE FANCG GTF2H2 RAD1 CDC25B ESPL1 PLK4

6.22e-0642614912M9516
CoexpressionSAGIV_CD24_TARGETS_UP

USP34 DNAJC13 ARFGEF1 PLPPR2

6.77e-06221494M4144
CoexpressionKAUFFMANN_DNA_REPAIR_GENES

ATR HUS1 POLM APEX1 REV3L FANCA FANCG GTF2H2 RAD1

7.10e-062301499M11563
CoexpressionBROWNE_HCMV_INFECTION_14HR_DN

CAND2 BAX REV3L ARHGEF17 DENND3 NEK1 ZFR CDC25B MPI

4.43e-052901499M13251
CoexpressionAtlasdev gonad_e13.5_F_MeioticGermCell_Oct_k-means-cluster#3_top-relative-expression-ranked_1000

HORMAD2 LYST FBXO47 TASOR2 PIKFYVE NEK1 TAF7L HTT DOP1A

5.69e-061871459gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_k3_1000
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

USP34 DIP2B ATR MED1 TASOR2 CEP350 LATS1 FAM120A CRYBG3 DYNC1H1

1.09e-0919314910abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l48|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

POLM DGKA NEK1 IGHMBP2 MIEF1 NLRC5 KIF3C CDC25B

1.11e-071701498070d8683d1a5cc7d594ff0453c961a9bf982c2d0
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Papillary_Renal_Cell_Carcinoma|TCGA-Kidney / Sample_Type by Project: Shred V9

FLII DLGAP1 ARHGAP40 CAPN1 ARHGAP39 TUFM IFRD2

3.04e-06185149746f4f6f20b1e152922f6f2ba1244c56e48a49b79
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

USP34 ARFGEF1 BTAF1 TASOR2 ITPR1 FAM13A DYNC1H1

3.38e-061881497ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellControl-Neu_4|Control / 5 Neutrophil clusters in COVID-19 patients

APEX1 XPNPEP1 HEATR1 TUFM ARSD HTT CDK6

4.45e-061961497b8b7b54ca17a08fa775507bb22b1c7248ada8f40
ToppCellfacs-Liver-Non-hepatocytes-3m-Myeloid-neutrophil|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NHSL2 CAPN1 TMC4 LYST FANCA C5AR1

1.91e-0516414968e6dbddacd56a07769163813e3ebfad13302bb62
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOXD2 CAND2 PIKFYVE EIF2D PLK4 TBCE

2.58e-05173149612f779b8dce79431b2d1002ba524dd3f9566aeb0
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HIGD1B LRRC9 ESCO2 ART3 CDC25B PLK4

2.75e-05175149615c69dd5635c9251c535f1e22467712e9667ae92
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCAPD3 NHSL2 FANCA ESCO2 GSDME PLK4

3.33e-051811496566249e04dd491e6287ad2101b7b1ab11031ed8b
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCAPD3 NHSL2 FANCA ESCO2 GSDME PLK4

3.33e-051811496db9528dc7cb0230e4c36cb27da69102c588c7ee9
ToppCellControl-Neu_4|World / 5 Neutrophil clusters in COVID-19 patients

ABHD2 XPNPEP1 MED15 ARSD HDGFL2 HTT

3.65e-051841496ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCell15-Trachea-Epithelial-Multiciliated_precursor|Trachea / Age, Tissue, Lineage and Cell class

HSPA4L RTTN CEP350 ZBTB21 SPAG17 PLK4

3.76e-0518514969a8b8360d99375b726ca8e3c9a3f9b08919892d7
ToppCell368C-Lymphocytic-NK_cells-Proliferating_NK_cell|368C / Donor, Lineage, Cell class and subclass (all cells)

DENND3 FANCA ESCO2 RAD1 CRAMP1 FBXO34

4.23e-05189149631d34bc75d4457fca197e1766922e987dbd5f8a9
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

FMO4 LRSAM1 NAP1L5 AK9 DYNC1H1 HTT

4.49e-051911496cadb7a9de16f4bb21606de0e25cddd2d748c7f0b
ToppCellImmune_cells-small_pre-B.|Immune_cells / Lineage and Cell class

NCAPD3 TRIB2 POLM ESCO2 CCNG2 CDC25B

4.90e-0519414966a440c09805110b1e48e5959a3a9e094c6716bfb
ToppCellsevere_influenza-T/NK_proliferative|severe_influenza / disease group, cell group and cell class (v2)

NCAPD3 ESCO2 FANCG CDC25B ESPL1 PLK4

5.64e-051991496638b1491c47f2884daf1c1d38a779ad8e0f59c52
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

USP34 RTTN ARFGEF1 BTAF1 NLRC5 DDX24

5.64e-051991496f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellsevere_influenza-T/NK_proliferative|World / disease group, cell group and cell class (v2)

NCAPD3 ESCO2 FANCG CDC25B ESPL1 PLK4

5.64e-0519914961541f655f7d12c650added3683d07e5417a68dfb
ToppCellFrontal_cortex-Neuronal|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

USP34 DLGAP1 HECTD4 ZFR KIF5A DDX24

5.64e-051991496f88039d862f3bfa01dc39d2de4f3f548dc5a0e61
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma|TCGA-Liver / Sample_Type by Project: Shred V9

POLM EIF2D PIGT HDGFL2 PLPPR2 TBCE

5.80e-0520014969cff8be6e566f342fc8b45e93106d033b14759ee
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-T/NK_proliferative|COVID-19_Mild / Disease, condition lineage and cell class

NCAPD3 FANCA ESCO2 FANCG ESPL1 PLK4

5.80e-0520014966126a3bbafe2110fba0c1c4493035df4e8193d22
ToppCellTCGA-Liver-Primary_Tumor|TCGA-Liver / Sample_Type by Project: Shred V9

POLM EIF2D PIGT HDGFL2 PLPPR2 TBCE

5.80e-052001496b667168081393433597f6ca8baeddba1d1906d40
ToppCellInfluenza-Influenza_Severe-Lymphocyte-T/NK-T/NK_proliferative|Influenza_Severe / Disease, condition lineage and cell class

TMEM121 ESCO2 FANCG CDC25B ESPL1 PLK4

5.80e-052001496e1c266525ce6b42a4451b6a3b0cabf41ff5e2ee7
Drugnaringenin

BAX APOB MED1 LYST MED15 PIKFYVE GSDME KLHDC3

3.08e-061361488CID000000932
DrugClomiphene citrate (Z,E) [50-41-9]; Up 200; 6.6uM; HL60; HT_HG-U133A

USP34 ABHD2 BAX LYST ASAP1 NEK1 KLHDC3 PLK4 CDK6

4.99e-0619314891269_UP
DrugAzaguanine-8 [134-58-7]; Down 200; 26.2uM; MCF7; HT_HG-U133A

USP34 ABHD2 ARFGEF1 PIKFYVE CCNG2 NEK1 PIGT PLK4 TBCE

5.42e-0619514897444_DN
DiseaseCharcot-Marie-Tooth disease

SH3TC2 SBF1 IGHMBP2 DYNC1H1

4.86e-05421414cv:C0007959
DiseaseGrowth retardation, pre- and postnatal

FANCA FANCG

6.78e-0531412C2750866
Diseaseovarian cancer (is_implicated_in)

MUC16 APEX1 APOB FANCA

1.51e-04561414DOID:2394 (is_implicated_in)
DiseaseLarge cell carcinoma of lung

ATR NEK1 LATS1

4.79e-04321413C0345958
Diseaselevel of Phosphatidylinositol (16:0_18:2) in blood serum

TMC4 RMDN2

6.23e-0481412OBA_2045153
Diseasetumor necrosis factor receptor superfamily member 19L measurement

ARHGEF17 PIKFYVE

6.23e-0481412EFO_0008309
Diseaseneurodegenerative disease (implicated_via_orthology)

SLC1A2 LATS1 KIF5A DYNC1H1 HTT

6.76e-041451415DOID:1289 (implicated_via_orthology)
Diseasecysteine measurement

FMO4 TTL

7.98e-0491412EFO_0021000
DiseaseIgG bisecting N-acetyl glucosamine measurement

TMEM121 KIF3C

7.98e-0491412EFO_0008426
DiseaseFanconi anemia (is_implicated_in)

FANCA FANCG

9.95e-04101412DOID:13636 (is_implicated_in)
Diseasecytochrome p450 3a4 measurement

APOB PIKFYVE

1.21e-03111412EFO_0020303
Diseasehearing impairment

FANCA FANCG SH3PXD2B GSDME

1.27e-03981414C1384666
Diseasehigh density lipoprotein particle size measurement

APOB INTS10 PIGT FAM13A NLRC5

1.38e-031701415EFO_0008592
DiseaseAlzheimer's disease (is_marker_for)

ATR CAPN1 BAX ITPR1 C5AR1 DYNC1H1

1.52e-032571416DOID:10652 (is_marker_for)
Diseasereticulocyte measurement

GPHN USP34 ATR HSPA4L KBTBD8 HECTD4 SPPL3 DENND3 PIKFYVE RANBP3L IFRD2 HDGFL2 FBXO34

1.66e-03105314113EFO_0010700
DiseaseCharcot-Marie-Tooth disease type 4

SH3TC2 SBF1

1.71e-03131412cv:C4082197
Diseasemyeloid white cell count

USP34 DNAJC13 TRIB2 HECTD4 SPPL3 FAM13A NLRC5 KIF3C SPAG17 FBXO34 HTT CDK6

1.85e-0393714112EFO_0007988
Diseaseaspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement

TRIB2 FANCA UBN1 FAM13A UNC79 HTT SENP7

1.89e-033641417EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
DiseaseFanconi anemia

FANCA FANCG

1.99e-03141412cv:C0015625
Diseaseplatelet crit

DIP2B TRIB2 NHSL2 RTTN BAX APOB TMC4 FBXO47 SVIL HDGFL2 SENP7 CDK6

2.11e-0395214112EFO_0007985
DiseaseFEV/FEC ratio

USP34 CES5A ARHGEF17 SLC1A2 DENND3 ASAP1 ITPR1 MED15 CCNG2 FAM13A SVIL C5AR1 PLPPR2 SMURF2

2.31e-03122814114EFO_0004713
Diseasecholesterol to total lipids in large HDL percentage

APOB INTS10 FAM13A

2.34e-03551413EFO_0022234
Diseasetriglycerides to total lipids in medium HDL percentage

APOB INTS10 NLRC5

2.46e-03561413EFO_0022333
Diseasecholesteryl esters to total lipids in medium HDL percentage

APOB INTS10 NLRC5

2.46e-03561413EFO_0022251
Diseasebody fat percentage

TRIB2 TUFM FANCA UBN1 FAM13A UNC79 HTT SENP7

2.47e-034881418EFO_0007800
Diseasemean corpuscular hemoglobin concentration

DNAJC13 ATR HSPA4L LRSAM1 RTTN HECTD4 XPNPEP1 FOCAD FANCG KIF3C HDGFL2 PLK4 SENP7

2.52e-03110514113EFO_0004528
Diseasediastolic blood pressure, body mass index

EFHC2 GLP1R

2.60e-03161412EFO_0004340, EFO_0006336
Diseasepancreatic ductal carcinoma (is_implicated_in)

HEATR1 CDK6

2.60e-03161412DOID:3587 (is_implicated_in)
DiseaseHuntington's disease (biomarker_via_orthology)

BAX ITPR1

2.60e-03161412DOID:12858 (biomarker_via_orthology)
Diseasecholesterol in medium HDL measurement

APOB INTS10 NLRC5

2.86e-03591413EFO_0021903
Diseasehair colour measurement

FLII ILF3 KBTBD8 REV3L LYST ANKRD27 FANCA FAM13A IGHMBP2

2.88e-036151419EFO_0007822
DiseaseCharcot-Marie-Tooth disease type 2

IGHMBP2 DYNC1H1

2.94e-03171412cv:C0270914
Diseasetriglycerides to total lipids in large HDL percentage

APOB INTS10 NLRC5

3.00e-03601413EFO_0022330
Diseasecholesterol to total lipids in medium HDL percentage

APOB INTS10 NLRC5

3.00e-03601413EFO_0022237
Diseasefree cholesterol in HDL measurement

APOB INTS10 NLRC5

3.14e-03611413EFO_0022264
Diseasetriglycerides:total lipids ratio, high density lipoprotein cholesterol measurement

APOB INTS10 PIGT FAM13A NLRC5

3.17e-032061415EFO_0004612, EFO_0020947
DiseaseAdenocarcinoma of lung (disorder)

ATR APEX1 NEK1 LATS1 ALB

3.17e-032061415C0152013
DiseaseBone marrow hypocellularity

FANCA FANCG

3.30e-03181412C1855710
DiseaseMalignant Neoplasms

ATR CAPN1 GLP1R CDK6

3.37e-031281414C0006826
Diseasetotal lipids in HDL measurement

APOB INTS10 NLRC5

3.44e-03631413EFO_0022307
Diseasethrombin activatable fibrinolysis inhibitor activation peptide measurement

KBTBD8 ITPR1

3.68e-03191412EFO_0008582
Diseasetotal lipids in very large HDL measurement

APOB PIGT NLRC5

3.92e-03661413EFO_0022312
Diseasephospholipids in very large HDL measurement

APOB PIGT NLRC5

3.92e-03661413EFO_0022298
Diseasecholesterol in very large HDL measurement

APOB PIGT NLRC5

4.45e-03691413EFO_0022229
Diseasereticulocyte count

USP34 ATR KBTBD8 HECTD4 SPPL3 EXOSC3 DENND3 PIKFYVE RANBP3L IFRD2 HDGFL2 FBXO34

4.46e-03104514112EFO_0007986

Protein segments in the cluster

PeptideGeneStartEntry
PLKVFIDLCLKESTL

PRAMEF33

146

A0A0G2JMD5
LLFLCLLLKTCEPKT

ARSD

21

P51689
LKCRVKKADLPLLTS

EIF2D

276

P41214
ADKAACLLPKLDELR

ALB

196

P02768
LGSLKRVLKDCSIPE

CRYBG3

2376

Q68DQ2
LSRFLLKSCPLLTKE

ABHD2

51

P08910
LSLRKKGLECLVSIL

ARFGEF1

606

Q9Y6D6
LKDSKVFPLLLCITL

GSDME

471

O60443
IFRLLPTKSLVALKC

FBXO34

586

Q9NWN3
NLLCKSPTLLITVRD

ABHD12B

341

Q7Z5M8
LIFSKAKPSVLALCL

CCNG2

196

Q16589
PLCASRNSKAKLRAL

BTBD11

781

A6QL63
LKDECALVPRTLATK

DLGAP1

81

O14490
DSLRLCSKILSKVQP

DOP1A

531

Q5JWR5
LLLKCLTFNPAKRIS

CDK6

276

Q00534
LLPALCDSKIRSKAL

APEX1

291

P27695
SSPTFLLLKKLDSLC

C5AR1

271

P21730
CNLTPDALKSRTIRK

CAPN1

351

P07384
SLKDCLSCLLALLKP

DENND3

121

A2RUS2
LLTFCRAASVLKALP

POLM

176

Q9NP87
IKAECSIRLPKAAKT

MTA2

491

O94776
SLLKPSTKALVLSCK

RAD1

226

O60671
LVLTKQKCPERFLSL

ARHGAP39

371

Q9C0H5
SPKKRLTLSEICEFI

FOXD1

141

Q16676
IIKARLSCDVKLDPR

GPHN

656

Q9NQX3
KGSDLKLLPCTSKAI

INTS10

546

Q9NVR2
KELTNLTRLPCLKDL

LRRC9

181

Q6ZRR7
RKLASSKSCLDPEFL

ARHGEF17

1471

Q96PE2
RLKETPLKCALNSKI

ANKRD27

596

Q96NW4
CRLTLLRPKKDGAAT

MUC16

13531

Q8WXI7
LAICRKLKLDPFLTP

nan

941

O00370
LLEKLLRSCPKVNSV

FAR1

26

Q8WVX9
LTSLPSAICKLSKLK

FLII

281

Q13045
CVSEKLLRKTRESPL

HIGD1B

16

Q9P298
KMLRTCSLPDLSKLF

NEK1

1046

Q96PY6
PSICEFLTKESKLRI

ITPR1

2221

Q14643
EVTRKLLCLDSRKPD

DNAAF2

301

Q9NVR5
KLSPEASDLIIKLCR

LATS1

976

O95835
AALPKATILDLSCNK

LRRC59

36

Q96AG4
LPKSCSLLSLATIKV

LRSAM1

71

Q6UWE0
KLLESLISPDCVLKV

NLRP11

936

P59045
KCRLAKSTLTLIPLL

GLP1R

346

P43220
LSLKILREDKKCPGS

HORMAD2

66

Q8N7B1
KASEALKVVARCRPL

KIF3C

6

O14782
TKDIKRLCKSSRLPL

EFHC2

656

Q5JST6
PKCTKLKCSSLRLIE

F13B

206

P05160
LKVKDIPCSSALLTI

PLXNA4

386

Q9HCM2
CPLQSKKLRKSLICE

CSTL1

101

Q9H114
EALLRCLRTKPSKEL

CES5A

286

Q6NT32
CLRTKPSKELLTLSQ

CES5A

291

Q6NT32
PVLLASLLLICKSSL

FMO4

521

P31512
ILKTCVPDLSDKRLE

DGKA

641

P23743
ALALTSEVCLKGLPK

DIP2B

456

Q9P265
DILTDPSKRCPLKTL

MED15

571

Q96RN5
FLLKSPIAPCSLDKR

CDC25B

466

P30305
LLDALTDPSRKTQKC

GCN1

1581

Q92616
LPLLCRGLAVEAKKT

TUFM

36

P49411
LLKASREKTPLIDLC

FAM120A

811

Q9NZB2
LCEELLSRTSSLLPK

FANCG

416

O15287
SLCLKILKAICKSTP

MIEF1

361

Q9NQG6
SCVPRLCSLTLKKLV

PACS2

36

Q86VP3
QLLLKSKVTAPLECS

CYHR1

286

Q6ZMK1
SKVTAPLECSFLLLK

CYHR1

291

Q6ZMK1
LSQPACVSKLLSLLL

HECTD4

1401

Q9Y4D8
CVSKLLSLLLDQRPS

HECTD4

1406

Q9Y4D8
CSAASLLKLFLRELP

FAM13A

111

O94988
LKLTEPKDLLIFRAC

MPI

406

P34949
LKVDSPDVKRCLNAL

HDGFL2

486

Q7Z4V5
FLLANTLSLCPRVKK

NLRC5

1181

Q86WI3
TLSLCPRVKKVDLRS

NLRC5

1186

Q86WI3
LSKPSLLRARIGCKL

KBTBD8

371

Q8NFY9
AALLPLVTAFCRKLS

SBF1

646

O95248
KGSRLVKPSLCLALL

PLPPR2

231

Q96GM1
LKKSPEALKCRLTEG

KAT6A

951

Q92794
PLLRLACTNTKKLEE

OR6S1

186

Q8NH40
LSGTLLLKRKARACP

BTBD18

201

B2RXH4
SSCIKNPKILLLKCS

PIKFYVE

696

Q9Y2I7
RNLKLSLPDFKELCT

APOB

3311

P04114
TRLTDKLLELCNKPV

ATR

2216

Q13535
VTPLKAKIASLVRKC

C4orf50

71

Q6ZRC1
CLEALKLTTKLQIPR

ESPL1

1011

Q14674
DCIPLLRKTLKDESS

HTT

806

P42858
KECKAVTLAVQPRLL

BTAF1

741

O14981
ILVRQCKSSLPRASK

C4orf45

156

Q96LM5
PTSKLDELLEKLCVS

COG3

391

Q96JB2
RLCDKLGKNLLLTLT

SLC1A2

36

P43004
LLEVEGPLCKKLSLS

FANCA

61

O15360
VLKALCTKVPELIRT

BAX

121

Q07812
SCLLKLISTEVNPKL

CRAMP1

731

Q96RY5
ELVLLCKEKPTTALL

ILF3

111

Q12906
ASEKLCTPLLDLLTR

CEP350

2711

Q5VT06
ECLKLLLRSKPTVDI

ASAP1

651

Q9ULH1
LPKVKRLLSDSTCLP

DNAJC13

1071

O75165
LLRIFLEKSPCTKIL

LYST

1361

Q99698
PLERKLIKESRSTCL

ESCO2

96

Q56NI9
PVLLLDATALKACKV

IFRD2

461

Q12894
SISCIKRLSGLLKVL

DDX24

596

Q9GZR7
FKRCTLLLPTKERLK

FBXO47

121

Q5MNV8
VRLSCLPAFKDLIAK

DYNC1H1

3936

Q14204
CELPKLEKRLRATAE

KIF5A

856

Q12840
ILDFSPSLKTLCKLA

KLHDC3

331

Q9BQ90
TKIPSLIKDGLSCLI

HEATR1

291

Q9H583
AKCIAALISSRPDLL

CAND2

356

O75155
SRKLAQLPDRCTLKT

SEC22A

41

Q96IW7
KVTLGLIRKLLAPDC

EXOSC3

201

Q9NQT5
PDSQKLLRCELESLK

CCDC159

26

P0C7I6
LSPKLSCDTRPLILK

FOCAD

651

Q5VW36
CLETLQKALKVTSLP

MED1

61

Q15648
LKSLPREVSLLQCLK

LRRC30

106

A6NM36
ISDTLELLRPKIKLC

UPF2

976

Q9HAU5
LQSPKKRLTLSEICE

FOXD2

141

O60548
SKLALALAIIRSKPA

MEI4

11

A8MW99
LALKLLQCLKVTDAP

RTTN

1241

Q86VV8
LKPNRLTCTLKLLEY

GTF2H2C;

76

Q6P1K8
LPCVIESLRTLDKKT

TAF7L

156

Q5H9L4
TLSELKSRFPKCAEL

AK9

1711

Q5TCS8
ANLPSILLKVCALLK

UTP20

1841

O75691
KRPCILILDSLKAAS

SENP7

931

Q9BQF6
KLCKTIYPLADLLAR

SVIL

2151

O95425
ALPKDQRPKSLCLSL

NHSL2

591

Q5HYW2
ESLPNSVKCRVLALK

NAP1L5

71

Q96NT1
KKARVVCLPVSLLQL

PKDREJ

1051

Q9NTG1
LAKTCTLRISPDKLN

HUS1

26

O60921
CNLALLLPTVTKEDK

RMDN2

381

Q96LZ7
QAKKALDVLEPLLCS

SH3TC2

811

Q8TF17
SLKDCLPKSAQLLKS

PLK4

876

O00444
LLKKSGCRTPRIELE

RPF2

201

Q9H7B2
SLLPSLCLSEREKKN

SPAG17

486

Q6Q759
DRCLDKAPTVRSKAL

NCAPD3

451

P42695
PVKLRLTVLCAKNLV

SMURF2

11

Q9HAU4
SSCLPEDLSLSKQLK

ZBTB21

861

Q9ULJ3
ILSELKALCADLSPR

XPNPEP1

271

Q9NQW7
RTLLTKCSLFPSLKD

ZNF365

56

Q70YC5
RKVPSLALIELTALC

ARHGAP40

231

Q5TG30
KLLPCSSKAGLSVLL

PIGT

191

Q969N2
DSCPAVSKILERSLK

REV3L

2861

O60673
ALSCLRNPLTKEDKE

TBCE

336

Q15813
LKPNRLTCTLKLLEY

GTF2H2

76

Q13888
KVKSIDLPIQSSLCR

HSPA4L

576

O95757
SLKELQSRGVCLLKL

IGHMBP2

36

P38935
VDICNLRSKLRPAKS

SH3PXD2B

661

A1X283
VRLPSLKVSCLLLSG

SPPL3

181

Q8TCT6
TLSPKAKCLIRSILR

TRIB2

276

Q92519
SQPSRKCLLEKIDVI

RANBP3L

276

Q86VV4
LKKLTLFSTCSPAAR

TMC4

566

Q7Z404
DPVARKALTLLLSVC

TMEM121

106

Q9BTD3
KSQPRKKESLLTCLA

USP12

71

O75317
PLKVFIDLCLKESTL

PRAMEF10

146

O60809
KRLKLLLFAPVACTS

UNC5A

591

Q6ZN44
LDAKKSPLALLAQTC

ZNF503

106

Q96F45
VNLVLLCSEKPSKTL

ZFR

806

Q96KR1
LCSEKPSKTLLSRIA

ZFR

811

Q96KR1
SFLPCSKDALLKRAR

UBN1

416

Q9NPG3
CALLETKKSLPEERI

TASOR2

186

Q5VWN6
KALSDKQSLPLRVVC

USP34

1201

Q70CQ2
AEKRACFKKLPRILS

USP34

2071

Q70CQ2
ALIPTLQELLSKCRT

USP34

3311

Q70CQ2
LCRKASLVKLIKTSP

TTL

71

Q8NG68
AKRLNLATECLPLDK

TRMT10C

326

Q7L0Y3
SCGSPLTLKQKRDLL

UNC79

1736

Q9P2D8
PITRLCSLKEQSILK

nan

156

Q96M85
LQLLRKPCEASSKTV

ART3

146

Q13508