Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionintracellularly cAMP-activated cation channel activity

HCN3 HCN2

2.52e-0410482GO:0005222
GeneOntologyMolecularFunctionintracellularly cyclic nucleotide-activated monoatomic cation channel activity

HCN3 HCN2

4.34e-0413482GO:0005221
GeneOntologyMolecularFunctioncyclic nucleotide-activated monoatomic ion channel activity

HCN3 HCN2

4.34e-0413482GO:0043855
GeneOntologyCellularComponentHCN channel complex

HCN3 HCN2

2.96e-054472GO:0098855
DomainIon_trans_N

HCN3 HCN2

3.87e-054482PF08412
DomainIon_trans_N

HCN3 HCN2

3.87e-054482IPR013621
DomainK_chnl_volt-dep_EAG/ELK/ERG

HCN3 HCN2

5.77e-0414482IPR003938
DomainATPase_dyneun-rel_AAA

MDN1 DNAH11

5.77e-0414482IPR011704
DomainAAA_5

MDN1 DNAH11

5.77e-0414482PF07728
DomainCNMP_BINDING_1

HCN3 HCN2

3.05e-0332482PS00888
DomainCNMP_BINDING_2

HCN3 HCN2

3.05e-0332482PS00889
DomaincNMP

HCN3 HCN2

3.44e-0334482SM00100
DomaincNMP_binding

HCN3 HCN2

3.44e-0334482PF00027
DomaincNMP-bd_dom

HCN3 HCN2

3.65e-0335482IPR000595
DomainCNMP_BINDING_3

HCN3 HCN2

3.65e-0335482PS50042
DomaincNMP-bd-like

HCN3 HCN2

4.29e-0338482IPR018490
DomainAAA+_ATPase

MDN1 ABCC12 DNAH11

6.02e-03144483IPR003593
DomainAAA

MDN1 ABCC12 DNAH11

6.02e-03144483SM00382
Domain-

HCN3 HCN2

6.77e-03484822.60.120.10
DomainRmlC-like_jellyroll

HCN3 HCN2

7.61e-0351482IPR014710
Pubmed

Hyperpolarization-activated cyclic nucleotide-modulated 'HCN' channels confer regular and faster rhythmicity to beating mouse embryonic stem cells.

HCN3 HCN2

1.94e-06249218033814
Pubmed

HCN3 ion channels: roles in sensory neuronal excitability and pain.

HCN3 HCN2

1.94e-06249231290157
Pubmed

A family of hyperpolarization-activated mammalian cation channels.

HCN3 HCN2

5.83e-0634929634236
Pubmed

Functional expression of the human HCN3 channel.

HCN3 HCN2

1.16e-05449216043489
Pubmed

Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia.

HCN3 HCN2

1.16e-05449225042871
Pubmed

Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder.

HCN3 HCN2

1.16e-05449222748890
Pubmed

Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons.

HCN3 HCN2

1.16e-05449226966193
Pubmed

Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.

HCN3 HCN2

1.16e-0544929630217
Pubmed

Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.

HCN3 HCN2

1.16e-0544929405696
Pubmed

Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.

HCN3 HCN2

1.16e-05449212928435
Pubmed

Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases.

HCN3 HCN2

1.16e-05449221615589
Pubmed

Hyperpolarization-activated and cyclic nucleotide-gated channels are differentially expressed in juxtaglomerular cells in the olfactory bulb of mice.

HCN3 HCN2

1.16e-05449220140458
Pubmed

Genome-wide association study of lung function decline in adults with and without asthma.

AGL PCDH15 CHD7

1.27e-053249322424883
Pubmed

Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice.

HCN3 HCN2

1.94e-05549234429357
Pubmed

Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction.

HCN3 HCN2

1.94e-05549215564593
Pubmed

Functional coupling of Tmem74 and HCN1 channels regulates anxiety-like behavior in BLA neurons.

HCN3 HCN2

1.94e-05549230886335
Pubmed

Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts.

HCN3 HCN2

4.07e-05749227956497
Pubmed

Transcription profiling of HCN-channel isotypes throughout mouse cardiac development.

HCN3 HCN2

4.07e-05749219421833
Pubmed

CHD7, the gene mutated in CHARGE syndrome, regulates genes involved in neural crest cell guidance.

SEMA3D CHD7

4.07e-05749224728844
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

MDN1 CUL9 MECOM CHD7 LGALS3BP

4.82e-0528249523667531
Pubmed

International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.

HCN3 HCN2

8.69e-051049216382102
Pubmed

Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.

HCN3 HCN2

1.75e-041449229107716
Pubmed

A critical role for the chromatin remodeller CHD7 in anterior mesoderm during cardiovascular development.

SEMA3D CHD7

2.61e-041749226102480
Pubmed

The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.

MECOM DNAH11

2.61e-041749223502783
Pubmed

Analysis of the asymmetrically expressed Ablim1 locus reveals existence of a lateral plate Nodal-independent left sided signal and an early, left-right independent role for nodal flow.

F10 DNAH11

3.64e-042049220487527
Pubmed

Co-adaptor driven assembly of a CUL3 E3 ligase complex.

AGL LNPK

4.41e-042249235120648
Pubmed

Human transcription factor protein interaction networks.

SEC24A BCORL1 CUL9 MECOM CHD7 SNRNP70 LGALS3BP NPAT

8.00e-04142949835140242
Pubmed

Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico.

CHD7 HMX1

1.39e-033949225859222
GeneFamilyCyclic nucleotide gated channels

HCN3 HCN2

1.44e-0410332250
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

GARIN5B TPTE2P1 PCDH15 MUC5B

2.18e-05149494c5eedb54ef2e0f131aa6730612c921bc19479632
ToppCellCOVID-19_Severe-B_cell|World / disease group, cell group and cell class

TUT4 MDN1 CHD7 ARHGAP20

2.18e-051494949a9fcbf7e8a6811958f3fd2d36315e19ab2b1127
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_granulocytic|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

GARIN5B TPTE2P1 PCDH15 MUC5B

2.18e-05149494a22417286de8606f0cc94f86b70bce17aeefb9c2
ToppCell5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA3D PCDH15 SLC35F6 LENEP

4.37e-051784944b3ea0921bc598ebb9f63780ecdf8ad4349f3666
ToppCell10x3'2.3-week_12-13-Myeloid_macrophage-stroma-erythroid_macrophage|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SEMA3D MRGPRF ARHGAP20 F10

4.46e-05179494c17ae394b855f01f8ca1765c416fd8b34a96e60b
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEMA3D PCDH15 ARHGAP20 SLC16A12

4.66e-051814949e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCelldroplet-Spleen-nan-24m-Lymphocytic-immature_NKT_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASF1B SKIDA1 HCN2 DNAH11

4.97e-05184494b998803180322a5ea2b567928dea531c26816c3c
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-OPC|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCDH15 CHD7 HMX1 DNAH11

5.29e-05187494daff7ccd3f1924cf2b34d3aca3eccde245aaf371
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCDH15 CHD7 HMX1 DNAH11

5.29e-051874945b7a1edee602e55d3400dc17dbb6b8aaa26defc0
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEMA3D PCDH15 ARHGAP20 SLC16A12

5.51e-051894942a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SEMA3D PCDH15 ARHGAP20 SLC16A12

6.10e-0519449460622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCellParenchymal-10x3prime_v2-Stromal-Mesofibroblastic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TRAF3IP2 MRGPRF SKIDA1 F10

6.60e-051984940cd930e374c2c48d1991b51c025f9801b22ecee7
ToppCellParenchymal-10x3prime_v2-Stromal-Mesofibroblastic-Mesothelia|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TRAF3IP2 MRGPRF SKIDA1 F10

6.60e-05198494e0df6d6ff2a9c41d813f84a2a5ee7cb5f6fc3e30
ToppCellBronchus_Control_(B.)-Stromal-TX-Mesothelial-2|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

MRGPRF EXTL1 F10 SLC16A12

6.73e-0519949460a653100aff31f7f96796ff2ec634798bfb4b0d
Diseaseprostate cancer, disease progression measurement

HCN2 F10

5.87e-0424442EFO_0008336, MONDO_0008315
DiseaseCongenital small ears

CHD7 HMX1

1.72e-0341442C0152423

Protein segments in the cluster

PeptideGeneStartEntry
CFPAAQAPAMQKVPL

BCORL1

421

Q5H9F3
APFFQAQMILLPPEI

DNAH11

941

Q96DT5
FLPLLMTNHPAPNLF

POLE2

106

P56282
LRCPVFMSFLPLPNR

ASB14

551

A6NK59
NPLAFNPFLLSTMAP

CHD7

2886

Q9P2D1
PPQPLCDLMLSQVFA

MUC5B

5286

Q9HC84
LNQLFPEAIFPMCPE

PTPN3

611

P26045
SVPSMFNFRAPPNAL

MECOM

886

Q03112
MPLTAPVCNRSIPQF

NPAT

971

Q14207
FLSRIFQVPPGQMPN

DNAJC14

646

Q6Y2X3
TPNPNFRLFLSMDPV

MDN1

2281

Q9NU22
MQPRTQPLAQTLPFF

LENEP

1

Q9Y5L5
LFAILLPQDPSFQMP

LGALS3BP

246

Q08380
PTPRFCRKPIYLMNN

KRT39

61

Q6A163
FPAAASVPFLRAQMP

HMX1

331

Q9NP08
PMVLLDFPPLACFLN

COG8

426

Q96MW5
GCLQFLVPMLQDFPP

HCN3

266

Q9P1Z3
ILMLPFPFCGPNTLD

OR4D6

161

Q8NGJ1
MPAPTQLFFPLIRNC

PDP1

1

Q9P0J1
LGPMFLPCVLVPNTR

PCDH15

261

Q96QU1
MFVFQADAPNPSLIP

ASF1B

71

Q9NVP2
FSMPPPVVCRLLYQE

DMRTC2

186

Q8IXT2
MPPLAPQLCRAVFLV

LLCFC1

1

Q96L11
PLRRTFPNIQLCFML

LLCFC1

106

Q96L11
IGLCFPNRLPQLMLQ

CUL9

1621

Q8IWT3
IVCAPMFKLSPQFPN

EIF2B2

266

P49770
PITFRMNVAPACLPE

F10

331

P00742
MSFCPQVARPLVGPL

HCN2

736

Q9UL51
NLLKFPICNPTPYRM

NOA1

386

Q8NC60
TPFNLQEPFLMEQLP

ARHGAP20

286

Q9P2F6
MTQFLPPNLLALFAP

SNRNP70

1

P08621
CLPMLQSLPLLVPFS

SLC16A12

366

Q6ZSM3
LPPPAVMNYIFLLLC

MRGPRF

41

Q96AM1
QQPGLMVPFSLRLFP

SEC24A

886

O95486
FMANFPCPPSLIIGR

SKIDA1

846

Q1XH10
LFCPLPATIPILMVF

ABCC12

236

Q96J65
PAPCPRTFQLGQAMV

EXTL1

166

Q92935
LKCPFDPQQPFASVM

SEMA3D

181

O95025
PQFEPQRYPACAQML

TRAF3IP2

246

O43734
QMMLGFPPPLFFQIC

SLC6A9

561

P48067
FNPLLFLPPALCDMT

SLC35F6

86

Q8N357
PFAPPICFLKPTANM

UEVLD

81

Q8IX04
MPAAFPCVFPPQSLQ

TPTE2P1

1

Q5T6R2
PCVFPPQSLQVFPQM

TPTE2P1

6

Q5T6R2
FLCRKPVFIMPQRPQ

ZNF382

276

Q96SR6
VMFFLQQRKPPLLPC

TUT4

526

Q5TAX3
VRFDPFNFLSLPLPM

USP32

901

Q8NFA0
NRPSLFGMPLIVPCT

USP32

1096

Q8NFA0
MTAPSCAFPVQFRQP

DUSP18

1

Q8NEJ0
LPLRPLPMFESNFVQ

GARIN5B

36

Q8N5Q1
VGSFVQPCLRPLMPA

AGL

601

P35573
CFFLNPARKTRPQAP

LNPK

301

Q9C0E8