Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cytoskeletal protein binding	MYH1 MYH4 KLHL5 MYL2 MYL9 MYO9A MYH14 SYNE1 DIAPH1 ARFGEF1 ROCK1 ACTN4 DLEC1 JAKMIP1 SNAP25 FYN MYL12B NEXN ADD2	1.99e-07	1099	87	19	GO:0008092
GeneOntologyMolecularFunction	actin filament binding	MYH1 MYH4 MYO9A MYH14 SYNE1 ACTN4 NEXN ADD2	6.66e-06	227	87	8	GO:0051015
GeneOntologyMolecularFunction	actin binding	MYH1 MYH4 KLHL5 MYL2 MYO9A MYH14 SYNE1 DIAPH1 ACTN4 NEXN ADD2	7.32e-06	479	87	11	GO:0003779
GeneOntologyMolecularFunction	microfilament motor activity	MYH1 MYH4 MYO9A MYH14	2.22e-05	38	87	4	GO:0000146
GeneOntologyMolecularFunction	myosin binding	MYL2 MYL9 ARFGEF1 SNAP25 MYL12B	3.49e-05	85	87	5	GO:0017022
GeneOntologyMolecularFunction	myosin heavy chain binding	MYL2 MYL9 MYL12B	5.20e-05	17	87	3	GO:0032036
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYH1 MYH4 MYO9A MYH14 DNAH1	1.66e-04	118	87	5	GO:0003774
GeneOntologyMolecularFunction	calcium ion binding	CAPN9 FAT2 TCHH MYL2 MYL9 PKD2L2 PCLO ACTN4 CALML5 MYL12B TBC1D9	4.02e-04	749	87	11	GO:0005509
GeneOntologyMolecularFunction	structural constituent of muscle	MYL2 MYL9 NEXN	8.69e-04	43	87	3	GO:0008307
GeneOntologyMolecularFunction	profilin binding	PCLO DIAPH1	1.42e-03	13	87	2	GO:0005522
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	MYO9A ARHGEF5 ASAP3 ARFGEF1 DEPDC5 HERC2 HERC1 TBC1D9	1.65e-03	507	87	8	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	MYO9A ARHGEF5 ASAP3 ARFGEF1 DEPDC5 HERC2 HERC1 TBC1D9	1.65e-03	507	87	8	GO:0030695
GeneOntologyCellularComponent	myosin complex	MYH1 MYH4 MYL2 MYL9 MYO9A MYH14 MYL12B	4.11e-09	59	85	7	GO:0016459
GeneOntologyCellularComponent	actin cytoskeleton	MYH1 MYH4 MYL2 MYL9 MYO9A MYH14 ARHGEF5 DIAPH1 ACTN4 LRRC7 SNAP25 FYN MYL12B NEXN ADD2	1.02e-08	576	85	15	GO:0015629
GeneOntologyCellularComponent	myosin II complex	MYH1 MYH4 MYL9 MYH14 MYL12B	9.01e-08	28	85	5	GO:0016460
GeneOntologyCellularComponent	supramolecular fiber	MYH1 COL6A3 MYH4 MYL2 MYL9 CFAP77 MYO9A MYH14 SYNE1 GRAMD2B DIAPH1 ACTN4 JAKMIP1 FYN MYL12B NEXN DNAH1	4.39e-06	1179	85	17	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	MYH1 COL6A3 MYH4 MYL2 MYL9 CFAP77 MYO9A MYH14 SYNE1 GRAMD2B DIAPH1 ACTN4 JAKMIP1 FYN MYL12B NEXN DNAH1	4.81e-06	1187	85	17	GO:0099081
GeneOntologyCellularComponent	perinuclear region of cytoplasm	TSNAXIP1 BPTF PDE4A PDE4C SYNE1 PCLO CEP250 ARFGEF1 DEPDC5 ACTN4 SNAP25 FYN GOLGA1 TP53BP2 EPG5	4.85e-06	934	85	15	GO:0048471
GeneOntologyCellularComponent	sarcomere	MYH1 MYH4 MYL2 MYL9 SYNE1 ACTN4 MYL12B NEXN	7.91e-06	249	85	8	GO:0030017
GeneOntologyCellularComponent	myofibril	MYH1 MYH4 MYL2 MYL9 SYNE1 ACTN4 MYL12B NEXN	1.54e-05	273	85	8	GO:0030016
GeneOntologyCellularComponent	contractile muscle fiber	MYH1 MYH4 MYL2 MYL9 SYNE1 ACTN4 MYL12B NEXN	2.38e-05	290	85	8	GO:0043292
GeneOntologyCellularComponent	muscle myosin complex	MYH1 MYH4 MYL9	3.50e-05	16	85	3	GO:0005859
GeneOntologyCellularComponent	myosin filament	MYH1 MYH4 MYH14	1.40e-04	25	85	3	GO:0032982
GeneOntologyCellularComponent	contractile actin filament bundle	MYL9 MYH14 ACTN4 MYL12B	9.56e-04	107	85	4	GO:0097517
GeneOntologyCellularComponent	stress fiber	MYL9 MYH14 ACTN4 MYL12B	9.56e-04	107	85	4	GO:0001725
GeneOntologyCellularComponent	actomyosin	MYL9 MYH14 ACTN4 MYL12B	1.33e-03	117	85	4	GO:0042641
GeneOntologyCellularComponent	actin filament bundle	MYL9 MYH14 ACTN4 MYL12B	1.37e-03	118	85	4	GO:0032432
GeneOntologyCellularComponent	ruffle	PDE4A ASAP3 DIAPH1 ROCK1 ABCA7	1.53e-03	206	85	5	GO:0001726
MousePheno	abnormal podocyte adhesion	MYO9A ACTN4	2.69e-05	2	73	2	MP:0011864
Domain	EF_HAND_2	CAPN9 TCHH MYL2 MYL9 EFCAB13 ACTN4 CALML5 MYL12B TBC1D9	1.06e-06	231	85	9	PS50222
Domain	-	CAPN9 TCHH MYL2 MYL9 EFCAB13 ACTN4 CALML5 MYL12B TBC1D9	2.89e-06	261	85	9	1.10.238.10
Domain	EF_HAND_1	CAPN9 TCHH MYL2 MYL9 EFCAB13 ACTN4 CALML5 MYL12B	4.14e-06	204	85	8	PS00018
Domain	EF-hand_1	CAPN9 TCHH MYL2 MYL9 ACTN4 CALML5 MYL12B	5.97e-06	152	85	7	PF00036
Domain	EF-hand-dom_pair	CAPN9 TCHH MYL2 MYL9 EFCAB13 ACTN4 CALML5 MYL12B TBC1D9	6.25e-06	287	85	9	IPR011992
Domain	EF_hand_dom	CAPN9 TCHH MYL2 MYL9 ACTN4 CALML5 MYL12B TBC1D9	1.06e-05	232	85	8	IPR002048
Domain	EF_Hand_1_Ca_BS	CAPN9 TCHH MYL2 MYL9 ACTN4 CALML5 MYL12B	1.50e-05	175	85	7	IPR018247
Domain	ARHGEF5_35	ARHGEF35 ARHGEF5	2.05e-05	2	85	2	PF15441
Domain	ARHGEF5/35_N	ARHGEF35 ARHGEF5	2.05e-05	2	85	2	IPR029212
Domain	EF-hand_6	MYL2 MYL9 MYL12B	2.52e-05	13	85	3	PF13405
Domain	Myosin_head_motor_dom	MYH1 MYH4 MYO9A MYH14	2.62e-05	38	85	4	IPR001609
Domain	MYOSIN_MOTOR	MYH1 MYH4 MYO9A MYH14	2.62e-05	38	85	4	PS51456
Domain	Myosin_head	MYH1 MYH4 MYO9A MYH14	2.62e-05	38	85	4	PF00063
Domain	MYSc	MYH1 MYH4 MYO9A MYH14	2.62e-05	38	85	4	SM00242
Domain	Myosin_N	MYH1 MYH4 MYH14	3.98e-05	15	85	3	PF02736
Domain	Myosin_N	MYH1 MYH4 MYH14	3.98e-05	15	85	3	IPR004009
Domain	Myosin_tail_1	MYH1 MYH4 MYH14	7.07e-05	18	85	3	PF01576
Domain	Myosin_tail	MYH1 MYH4 MYH14	7.07e-05	18	85	3	IPR002928
Domain	Myosin-like_IQ_dom	MYH1 MYH4 MYH14	8.36e-05	19	85	3	IPR027401
Domain	-	MYH1 MYH4 MYH14	8.36e-05	19	85	3	4.10.270.10
Domain	EFh	CAPN9 MYL2 MYL9 ACTN4 CALML5 MYL12B	8.40e-05	158	85	6	SM00054
Domain	IQ	MYH1 MYH4 MYO9A MYH14	3.08e-04	71	85	4	PF00612
Domain	IQ	MYH1 MYH4 MYO9A MYH14	5.09e-04	81	85	4	SM00015
Domain	IQ_motif_EF-hand-BS	MYH1 MYH4 MYO9A MYH14	7.58e-04	90	85	4	IPR000048
Domain	IQ	MYH1 MYH4 MYO9A MYH14	8.57e-04	93	85	4	PS50096
Domain	GRAM	GRAMD2B TBC1D9	2.36e-03	16	85	2	SM00568
Domain	Post-SET_dom	KMT2D ASH1L	2.36e-03	16	85	2	IPR003616
Domain	PostSET	KMT2D ASH1L	2.36e-03	16	85	2	SM00508
Domain	POST_SET	KMT2D ASH1L	2.36e-03	16	85	2	PS50868
Domain	PDEase	PDE4A PDE4C	3.33e-03	19	85	2	IPR023088
Domain	RCC1	HERC2 HERC1	3.69e-03	20	85	2	PF00415
Domain	PDEase_I	PDE4A PDE4C	4.06e-03	21	85	2	PF00233
Domain	RCC1_1	HERC2 HERC1	4.06e-03	21	85	2	PS00625
Domain	RCC1_2	HERC2 HERC1	4.06e-03	21	85	2	PS00626
Domain	RCC1_3	HERC2 HERC1	4.06e-03	21	85	2	PS50012
Domain	PDEASE_I	PDE4A PDE4C	4.06e-03	21	85	2	PS00126
Domain	PDEase_CS	PDE4A PDE4C	4.06e-03	21	85	2	IPR023174
Domain	Reg_chr_condens	HERC2 HERC1	4.46e-03	22	85	2	IPR000408
Domain	GRAM	GRAMD2B TBC1D9	4.46e-03	22	85	2	PF02893
Domain	GRAM	GRAMD2B TBC1D9	4.46e-03	22	85	2	IPR004182
Domain	-	HERC2 HERC1	4.46e-03	22	85	2	2.130.10.30
Domain	-	PDE4A PDE4C	4.46e-03	22	85	2	1.10.1300.10
Domain	Znf_FYVE_PHD	BPTF KMT2D PCLO ASH1L	4.55e-03	147	85	4	IPR011011
Domain	PHD	BPTF KMT2D ASH1L	4.85e-03	75	85	3	PF00628
Domain	Actinin_actin-bd_CS	SYNE1 ACTN4	4.87e-03	23	85	2	IPR001589
Domain	Spectrin	SYNE1 ACTN4	4.87e-03	23	85	2	PF00435
Domain	PDEase_catalytic_dom	PDE4A PDE4C	4.87e-03	23	85	2	IPR002073
Domain	ACTININ_2	SYNE1 ACTN4	4.87e-03	23	85	2	PS00020
Domain	ACTININ_1	SYNE1 ACTN4	4.87e-03	23	85	2	PS00019
Domain	RCC1/BLIP-II	HERC2 HERC1	4.87e-03	23	85	2	IPR009091
Domain	HDc	PDE4A PDE4C	5.29e-03	24	85	2	SM00471
Domain	HD/PDEase_dom	PDE4A PDE4C	5.29e-03	24	85	2	IPR003607
Pathway	KEGG_MEDICUS_PATHOGEN_SHIGELLA_IPAA_TO_ITGA_B_RHOGEF_RHOA_SIGNALING_PATHWAY	MYL2 MYL9 ROCK1 MYL12B	1.79e-07	11	70	4	M47721
Pathway	KEGG_TIGHT_JUNCTION	MYH1 MYH4 MYL2 MYL9 MYH14 ASH1L ACTN4 MYL12B	2.77e-07	132	70	8	M11355
Pathway	REACTOME_EPHA_MEDIATED_GROWTH_CONE_COLLAPSE	MYL9 MYH14 ROCK1 FYN MYL12B	2.83e-07	29	70	5	M27309
Pathway	BIOCARTA_ECM_PATHWAY	MYL2 DIAPH1 ROCK1 FYN	2.04e-06	19	70	4	M6355
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_ROCKS	MYL9 MYH14 ROCK1 MYL12B	2.04e-06	19	70	4	M27493
Pathway	REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE	MYL9 MYH14 ROCK1 MYL12B	2.54e-06	20	70	4	M18415
Pathway	BIOCARTA_ECM_PATHWAY	MYL2 DIAPH1 ROCK1 FYN	3.13e-06	21	70	4	MM1390
Pathway	BIOCARTA_RHO_PATHWAY	MYL2 ARHGEF5 DIAPH1 ROCK1	3.13e-06	21	70	4	M1001
Pathway	REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING	MYL9 MYH14 ROCK1 MYL12B	5.50e-06	24	70	4	M2243
Pathway	KEGG_FOCAL_ADHESION	COL6A3 MYL2 MYL9 DIAPH1 ROCK1 ACTN4 FYN MYL12B	6.11e-06	199	70	8	M7253
Pathway	KEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPB_TO_RHOA_SIGNALING_PATHWAY	MYL2 MYL9 MYL12B	1.37e-05	10	70	3	M47739
Pathway	REACTOME_SEMAPHORIN_INTERACTIONS	MYL9 MYH14 ROCK1 FYN MYL12B	1.59e-05	64	70	5	M7923
Pathway	REACTOME_RHOB_GTPASE_CYCLE	MYO9A ARHGEF5 DIAPH1 ROCK1 CAVIN1	2.29e-05	69	70	5	MM15596
Pathway	REACTOME_RHOB_GTPASE_CYCLE	MYO9A ARHGEF5 DIAPH1 ROCK1 CAVIN1	2.46e-05	70	70	5	M41806
Pathway	WP_FOCAL_ADHESION	MYL2 MYL9 DIAPH1 ROCK1 ACTN4 FYN MYL12B	5.68e-05	199	70	7	M39402
Pathway	KEGG_REGULATION_OF_ACTIN_CYTOSKELETON	MYL2 MYL9 MYH14 DIAPH1 ROCK1 ACTN4 MYL12B	8.72e-05	213	70	7	M18306
Pathway	REACTOME_EPH_EPHRIN_SIGNALING	MYL9 MYH14 ROCK1 FYN MYL12B	9.19e-05	92	70	5	M27201
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_CIT	MYL9 MYH14 MYL12B	1.07e-04	19	70	3	M27489
Pathway	BIOCARTA_RHO_PATHWAY	ARHGEF5 DIAPH1 ROCK1	1.26e-04	20	70	3	MM1476
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_PAKS	MYL9 MYH14 MYL12B	1.46e-04	21	70	3	M27494
Pathway	WP_SILDENAFIL_TREATMENT	PDE4A PDE4C GUCY1B2	1.93e-04	23	70	3	M46455
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_PAKS	MYL9 MYH14 MYL12B	1.93e-04	23	70	3	MM15222
Pathway	KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	MYL2 MYL9 ROCK1 ACTN4 MYL12B	2.73e-04	116	70	5	M2164
Pathway	REACTOME_RHOC_GTPASE_CYCLE	ARHGEF5 DIAPH1 ROCK1 CAVIN1	3.99e-04	70	70	4	MM15597
Pathway	KEGG_VIRAL_MYOCARDITIS	MYH1 MYH4 MYH14 FYN	3.99e-04	70	70	4	M12294
Pathway	REACTOME_RHOC_GTPASE_CYCLE	ARHGEF5 DIAPH1 ROCK1 CAVIN1	4.94e-04	74	70	4	M41807
Pathway	REACTOME_SMOOTH_MUSCLE_CONTRACTION	MYL9 GUCY1B2 MYL12B	6.85e-04	35	70	3	MM15114
Pathway	REACTOME_RHOA_GTPASE_CYCLE	MYO9A ARHGEF5 DIAPH1 ROCK1 CAVIN1	6.92e-04	142	70	5	MM15576
Pathway	REACTOME_RHOA_GTPASE_CYCLE	MYO9A ARHGEF5 DIAPH1 ROCK1 CAVIN1	8.59e-04	149	70	5	M41805
Pathway	WP_STRIATED_MUSCLE_CONTRACTION_PATHWAY	MYL2 MYL9 ACTN4	8.73e-04	38	70	3	M39549
Pathway	PID_ECADHERIN_STABILIZATION_PATHWAY	MYL2 DIAPH1 ROCK1	1.09e-03	41	70	3	M232
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	CKB MYL9 MYO9A MYH14 ARHGEF5 DIAPH1 NUP43 ROCK1 CAVIN1 MYL12B	1.30e-03	649	70	10	MM15690
Pathway	PID_RHOA_PATHWAY	MYL2 DIAPH1 ROCK1	1.43e-03	45	70	3	M12
Pathway	REACTOME_RHO_GTPASE_EFFECTORS	MYL9 MYH14 DIAPH1 NUP43 ROCK1 MYL12B	1.71e-03	257	70	6	MM14755
Pubmed	Functional proteomics mapping of a human signaling pathway.	KMT2D EVC2 CEP250 ASH1L USP25 DIAPH1 ROCK1 HERC2 HERC1 TP53BP2 EPG5	3.43e-07	591	89	11	15231748
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	MYH14 CPSF6 ACTN4 HSPBP1 USP54 FYN CNTROB TRIM22 GPAT4 CCDC136 TP53BP2	4.54e-07	608	89	11	16713569
Pubmed	Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis.	MYL2 MYL9 MYL12B	5.63e-07	7	89	3	8207020
Pubmed	A point mutation in Myh10 causes major defects in heart development and body wall closure.	MYL9 MYH14 ROCK1	1.92e-06	10	89	3	24825879
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	KLHL5 FAT2 KMT2D SYNE1 CEP250 DLST HERC1	2.46e-06	234	89	7	36243803
Pubmed	Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND.	MYL2 MYL9 MYL12B	2.63e-06	11	89	3	9171826
Pubmed	Human transcription factor protein interaction networks.	CKB TET2 BPTF KMT2D MYH14 TNIP2 SMCHD1 G3BP2 RLIM RBM6 USP54 HERC2 HERC1 CALML5 ARID3B	3.27e-06	1429	89	15	35140242
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	CKB MYL9 G3BP2 PCLO USP25 ROCK1 LRRC7 SNAP25 FYN ADD2	4.40e-06	621	89	10	22794259
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TET2 STX18 MYH14 MTIF2 SYNE1 ASH1L USP25 NUP43 DLST ACTN4 JAKMIP1 SNAP25 USP54 HERC2	4.73e-06	1285	89	14	35914814
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	G3BP2 PCLO TUT7 DIAPH1 RBM6 CAVIN1 PIPSL NEXN DNAH1	5.26e-06	496	89	9	31343991
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	MYL9 MYH14 CPSF6 SYNE1 G3BP2 RIOX1 ACTN4 CAVIN1 RIOK2 FYN MYL12B NEXN	5.49e-06	949	89	12	36574265
Pubmed	A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.	MYH14 DIAPH1 ACTN4 MYL12B	5.51e-06	45	89	4	22114352
Pubmed	ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts.	DIAPH1 ROCK1	6.48e-06	2	89	2	12021256
Pubmed	ROCK and Dia have opposing effects on adherens junctions downstream of Rho.	DIAPH1 ROCK1	6.48e-06	2	89	2	11992112
Pubmed	Osmotic stress transcription factor 1b (Ostf1b) promotes migration properties with the modulation of epithelial mesenchymal transition (EMT) phenotype in human embryonic kidney cell.	MYL2 ROCK1	6.48e-06	2	89	2	23732111
Pubmed	Interaction of the SH2 domain of Fyn with a cytoskeletal protein, beta-adducin.	FYN ADD2	6.48e-06	2	89	2	11526103
Pubmed	Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4.	PDE4A PDE4C	6.48e-06	2	89	2	23043089
Pubmed	Growth and muscle defects in mice lacking adult myosin heavy chain genes.	MYH1 MYH4	6.48e-06	2	89	2	9382868
Pubmed	Postnatal myosin heavy chain isoform expression in normal mice and mice null for IIb or IId myosin heavy chains.	MYH1 MYH4	6.48e-06	2	89	2	11150240
Pubmed	Somatic mutations in KMT2D and TET2 associated with worse prognosis in Epstein-Barr virus-associated T or natural killer-cell lymphoproliferative disorders.	TET2 KMT2D	6.48e-06	2	89	2	31311407
Pubmed	Skeletal muscle adaptations in response to voluntary wheel running in myosin heavy chain null mice.	MYH1 MYH4	6.48e-06	2	89	2	11744674
Pubmed	MusTRD can regulate postnatal fiber-specific expression.	MYH1 MYH4 MYL2	8.86e-06	16	89	3	16494860
Pubmed	GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.	MYL2 MYL9 MYL12B	8.86e-06	16	89	3	9136932
Pubmed	Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain endothelial cells.	MYL2 MYL9 MYL12B	8.86e-06	16	89	3	19794400
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	COL6A3 STX18 TUT7 GRAMD2B ASH1L DLST RIOX1 USP54 HERC2 MYL12B CNTROB TBC1D9 ADD2	1.30e-05	1215	89	13	15146197
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	MYO9A G3BP2 CEP250 ACTN4 LRRC7 HERC2 MYL12B ADD2	1.51e-05	430	89	8	32581705
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	CKB GUCY1B2 MYH14 CPSF6 SYNE1 SMCHD1 G3BP2 PCLO DIAPH1 POLRMT DLST ACTN4 HSPBP1 CALML5	1.52e-05	1425	89	14	30948266
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	ANKRD35 GALE CCDC9B MYH14 CPSF6 G3BP2 DIAPH1 RIOX1 ACTN4 FYN MYL12B TP53BP2 DNAH1	1.70e-05	1247	89	13	27684187
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	MYH14 G3BP2 TUT7 POLRMT RBM6 NUP43 USP54 HERC2	1.78e-05	440	89	8	34244565
Pubmed	LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression.	CKB MYL9 MYH14 G3BP2 DLST ACTN4 FYN MYL12B NEXN	1.82e-05	580	89	9	35676659
Pubmed	Transition of myosin heavy chain isoforms in human laryngeal abductors following denervation.	MYH1 MYH4	1.94e-05	3	89	2	26059207
Pubmed	Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice.	MYH1 MYH4	1.94e-05	3	89	2	36515178
Pubmed	Vascular smooth muscle cell glycocalyx mediates shear stress-induced contractile responses via a Rho kinase (ROCK)-myosin light chain phosphatase (MLCP) pathway.	MYL2 ROCK1	1.94e-05	3	89	2	28191820
Pubmed	mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety.	DIAPH1 ROCK1	1.94e-05	3	89	2	27880913
Pubmed	Proplatelet formation is regulated by the Rho/ROCK pathway.	MYL2 ROCK1	1.94e-05	3	89	2	17244674
Pubmed	Fyn Mediates High Glucose-Induced Actin Cytoskeleton Reorganization of Podocytes via Promoting ROCK Activation In Vitro.	ROCK1 FYN	1.94e-05	3	89	2	26881253
Pubmed	The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome.	TET2 KMT2D	1.94e-05	3	89	2	26551667
Pubmed	Targeting the metastasis suppressor, NDRG1, using novel iron chelators: regulation of stress fiber-mediated tumor cell migration via modulation of the ROCK1/pMLC2 signaling pathway.	MYL2 ROCK1	1.94e-05	3	89	2	23188716
Pubmed	Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells.	MYL9 MYL12B	1.94e-05	3	89	2	11942626
Pubmed	The tumor suppressor proteins ASPP1 and ASPP2 interact with C-Nap1 and regulate centrosome linker reassembly.	CEP250 TP53BP2	1.94e-05	3	89	2	25660448
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	MYH14 MTIF2 G3BP2 CEP250 TUT7 USP25 JAKMIP1 USP54 HERC2 GPAT4	2.35e-05	754	89	10	33060197
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	CKB STX18 CPSF6 TNIP2 SMCHD1 DLST ACTN4 HSPBP1 HERC2 CALML5 TBC1D9	2.38e-05	922	89	11	27609421
Pubmed	The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.	TSNAXIP1 MYL9 MTIF2 ACTN4 MYL12B NEXN	2.55e-05	225	89	6	25277244
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	CKB STX18 SDHAF3 CPSF6 MTIF2 SYNE1 G3BP2 PCLO TUT7 POLRMT DLST HERC2 HERC1 GPAT4	2.60e-05	1496	89	14	32877691
Pubmed	PML Recruits TET2 to Regulate DNA Modification and Cell Proliferation in Response to Chemotherapeutic Agent.	TET2 MYL9 MYH14 CALML5	2.71e-05	67	89	4	29735542
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	CKB COL6A3 MYH14 G3BP2 HSPBP1 HERC1	2.95e-05	231	89	6	36597993
Pubmed	Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner.	MYL9 G3BP2 PCLO LRRC7 MYL12B ADD2	3.10e-05	233	89	6	29518331
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	MYL9 DIAPH1 ACTN4 MYL12B NEXN GPAT4	3.25e-05	235	89	6	28378594
Pubmed	Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.	PDE4A MYL9 MYH14 G3BP2 POLRMT DLST ACTN4 HERC2 MYL12B	3.31e-05	626	89	9	33644029
Pubmed	Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.	MYH1 MYH4	3.87e-05	4	89	2	10388558
Pubmed	Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy.	ACTN4 LRRC7	3.87e-05	4	89	2	17968527
Pubmed	The mDial formin is required for neutrophil polarization, migration, and activation of the LARG/RhoA/ROCK signaling axis during chemotaxis.	DIAPH1 ROCK1	3.87e-05	4	89	2	19265163
Pubmed	Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.	PDE4A PDE4C	3.87e-05	4	89	2	9371714
Pubmed	Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine.	PDE4A PDE4C	3.87e-05	4	89	2	24732776
Pubmed	A human YAC transgene rescues craniofacial and neural tube development in PDGFRalpha knockout mice and uncovers a role for PDGFRalpha in prenatal lung growth.	MYH1 MYH4	3.87e-05	4	89	2	11023856
Pubmed	Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice.	PDE4A PDE4C	3.87e-05	4	89	2	34943270
Pubmed	beta-adducin (Add2) KO mice show synaptic plasticity, motor coordination and behavioral deficits accompanied by changes in the expression and phosphorylation levels of the alpha- and gamma-adducin subunits.	FYN ADD2	3.87e-05	4	89	2	19900187
Pubmed	BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity.	MYO9A ARFGEF1	3.87e-05	4	89	2	15644318
Pubmed	PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.	PDE4A PDE4C	3.87e-05	4	89	2	32738081
Pubmed	Three linked myosin heavy chain genes clustered within 370 kb of each other show independent transcriptional and post-transcriptional regulation during differentiation of a mouse muscle cell line.	MYH1 MYH4	3.87e-05	4	89	2	1985022
Pubmed	A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.	PDE4A PDE4C	3.87e-05	4	89	2	8413254
Pubmed	LAMB3 Promotes Myofibrogenesis and Cytoskeletal Reorganization in Endometrial Stromal Cells via the RhoA/ROCK1/MYL9 Pathway.	MYL9 ROCK1	3.87e-05	4	89	2	37801199
Pubmed	The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression.	MYH4 ASH1L	3.87e-05	4	89	2	30487570
Pubmed	Smooth muscle myosin light chain kinase expression in cardiac and skeletal muscle.	MYH1 MYH4	3.87e-05	4	89	2	11029314
Pubmed	ESCRT-0 Component Hrs Promotes Macropinocytosis of Kaposi's Sarcoma-Associated Herpesvirus in Human Dermal Microvascular Endothelial Cells.	ROCK1 ACTN4	3.87e-05	4	89	2	26819309
Pubmed	Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion.	PDE4A PDE4C	3.87e-05	4	89	2	22946044
Pubmed	Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma.	MYL2 ROCK1	3.87e-05	4	89	2	18648664
Pubmed	Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice.	PDE4A PDE4C	3.87e-05	4	89	2	33609559
Pubmed	Modulation of skeletal muscle fiber type by mitogen-activated protein kinase signaling.	MYH1 MYH4	3.87e-05	4	89	2	18417546
Pubmed	Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation.	MYH1 MYH4	3.87e-05	4	89	2	12547197
Pubmed	Aurora B but not rho/MLCK signaling is required for localization of diphosphorylated myosin II regulatory light chain to the midzone in cytokinesis.	MYL2 ROCK1	3.87e-05	4	89	2	23951055
Pubmed	Mouse myosin-19 is a plus-end-directed, high-duty ratio molecular motor.	MYL9 MYL12B	3.87e-05	4	89	2	24825904
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	MYO9A MYH14 SMCHD1 TUT7 DIAPH1 POLRMT DLST ACTN4 CAVIN1 HERC2 RIOK2 NEXN TP53BP2	3.97e-05	1353	89	13	29467282
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	MYL2 MYH14 CPSF6 SYNE1 PCLO ASH1L DIAPH1 ACTN4 EPG5 DNAH1	4.17e-05	807	89	10	30575818
Pubmed	NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.	TET2 BPTF ARID3B	4.53e-05	27	89	3	23395962
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CKB BPTF MYH14 SMCHD1 TUT7 POLRMT RBM6 ACTN4 HERC2	4.59e-05	653	89	9	22586326
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	MYL9 MYH14 G3BP2 ACTN4 CAVIN1 JAKMIP1 USP54 MYL12B	4.59e-05	503	89	8	36217030
Pubmed	Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.	KMT2D SMCHD1 DLST ARID3B	4.95e-05	78	89	4	28611094
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	MYH1 MYH4 TCHH MYL9 MYO9A MYH14 SYNE1 ACTN4 CALML5 MYL12B	6.06e-05	844	89	10	25963833
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	CKB KMT2D MYH14 ACTN4 USP54 MYL12B	6.20e-05	264	89	6	32814769
Pubmed	Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin.	ACTN4 LRRC7	6.44e-05	5	89	2	11160423
Pubmed	Detection of Gene and Protein Expression in Mouse Embryos and Tissue Sections.	MYH1 MYH4	6.44e-05	5	89	2	30737693
Pubmed	Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition.	DIAPH1 ROCK1	6.44e-05	5	89	2	15096506
Pubmed	The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice.	PDE4A PDE4C	6.44e-05	5	89	2	33944911
Pubmed	Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion.	DIAPH1 ROCK1	6.44e-05	5	89	2	19160018
Pubmed	Cullin-3-RING ubiquitin ligase activity is required for striated muscle function in mice.	MYH1 MYL2	6.44e-05	5	89	2	29653945
Pubmed	Sequential accumulation of mRNAs encoding different myosin heavy chain isoforms during skeletal muscle development in vivo detected with a recombinant plasmid identified as coding for an adult fast myosin heavy chain from mouse skeletal muscle.	MYH1 MYH4	6.44e-05	5	89	2	6196357
Pubmed	Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia.	DIAPH1 FYN	6.44e-05	5	89	2	18194650
Pubmed	A mouse homolog of dunce, a gene important for learning and memory in Drosophila, is preferentially expressed in olfactory receptor neurons.	PDE4A PDE4C	6.44e-05	5	89	2	8586960
Pubmed	Nip2/centrobin may be a substrate of Nek2 that is required for proper spindle assembly during mitosis in early mouse embryos.	CEP250 CNTROB	6.44e-05	5	89	2	19117032
Pubmed	Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro.	MYH1 MYH4	6.44e-05	5	89	2	3829126
Pubmed	Myosin heavy chain isoforms of the murine masseter muscle during pre- and post-natal development.	MYH1 MYH4	6.44e-05	5	89	2	12919077
Pubmed	Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6.	MYH1 MYH4 MYL2	6.91e-05	31	89	3	21985497
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	CKB MYO9A MYH14 SYNE1 G3BP2 PCLO DLST ACTN4 LRRC7 USP54 MYL12B ADD2 TP53BP2	7.03e-05	1431	89	13	37142655
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	CKB MYH1 MYL9 CPSF6 DIAPH1 ACTN4 MYL12B NEXN	7.34e-05	538	89	8	28524877
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	TET2 KMT2D PCLO DIAPH1 ROCK1 USP54 ARID3B	7.50e-05	398	89	7	35016035
Pubmed	Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development.	MYH1 MYH4 MYL2	8.36e-05	33	89	3	32094117
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	TET2 KMT2D GALE MYH14 CPSF6 SMCHD1 G3BP2 DIAPH1 DLST	8.79e-05	711	89	9	33022573
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	CKB G3BP2 CEP250 CAVIN1 HERC1 TBC1D9	9.44e-05	285	89	6	32838362
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	CKB MYL2 SYNE1 G3BP2 ROCK1 SNAP25 HERC2 HERC1 ADD2	9.56e-05	719	89	9	35337019
Interaction	PPP1R12A interactions	BPTF MYL9 TNIP2 G3BP2 RLIM ASH1L NUP43 ROCK1 ACTN4	1.26e-05	322	89	9	int:PPP1R12A
Interaction	KIF20A interactions	ANKRD35 MYL9 MYH14 SYNE1 TNIP2 G3BP2 PCLO POLRMT ACTN4 CAVIN1 USP54 HERC2 HERC1 SNAPC4 FYN MYL12B	1.31e-05	1052	89	16	int:KIF20A
Interaction	MYH14 interactions	TET2 MYL9 MYH14 RLIM DLST CAVIN1 MYL12B	2.06e-05	189	89	7	int:MYH14
GeneFamily	EF-hand domain containing	CAPN9 TCHH MYL2 MYL9 EFCAB13 CALML5 MYL12B TBC1D9	6.92e-07	219	61	8	863
GeneFamily	Myosin light chains\|EF-hand domain containing	MYL2 MYL9 MYL12B	1.30e-05	14	61	3	657
GeneFamily	Myosin heavy chains	MYH1 MYH4 MYH14	1.62e-05	15	61	3	1098
GeneFamily	WD repeat domain containing\|GRAM domain containing\|BEACH domain containing	GRAMD2B TBC1D9	8.53e-04	13	61	2	1146
GeneFamily	Phosphodiesterases	PDE4A PDE4C	2.95e-03	24	61	2	681
GeneFamily	PHD finger proteins	BPTF KMT2D ASH1L	3.49e-03	90	61	3	88
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	TET2 BPTF KLHL5 PCLO RLIM USP25 ARFGEF1 ROCK1 FYN	2.53e-10	199	89	9	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	BPTF SYNE1 SMCHD1 ASH1L ARFGEF1 HERC1 TRIM22	1.51e-07	199	89	7	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	(02)_MMP9/10+-(2)_GFP_FOXI1\|(02)_MMP9/10+ / shred by cell type by condition	BPTF KLHL5 MYL9 RLIM ROCK1 FYN NEXN	1.51e-07	199	89	7	18a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCell	AT1-AT2_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	CAPN9 CCDC9B MYL9 PCLO USP54 ABCA7	1.83e-06	183	89	6	6821dca076318115d360ff426eb1218cfe104063
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CKB ANO4 COL6A3 MYL9 SYNE1 NEXN	1.95e-06	185	89	6	e64e8c98dd88d91f6501d3fb10b60fd2f3c90af3
ToppCell	Substantia_nigra-Neuronal\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PCLO LRRC7 SNAP25 CHGB TBC1D9 ADD2	2.01e-06	186	89	6	3f889083fcffe516388e9b03a5e23af2010ced33
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CKB ANO4 COL6A3 MYL9 SYNE1 NEXN	2.14e-06	188	89	6	3177b2c1723268d330d3e9f24f9e24492ace6286
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	SMCHD1 ASH1L ARFGEF1 HERC1 TP53BP2 EPG5	2.14e-06	188	89	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	AT1-AT2_cells-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	CCDC9B MYL9 CAVIN1 USP54 NEXN ABCA7	2.14e-06	188	89	6	be710bc957118cf426dd71c2d57e6f1b41c9a467
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CKB ANO4 COL6A3 MYL9 SYNE1 NEXN	2.21e-06	189	89	6	7ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	COL6A3 SMCHD1 ASH1L ARFGEF1 HERC1 FYN	2.42e-06	192	89	6	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	390C-Fibroblasts-Fibroblast-K_(Pericytes)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CKB MYL9 ROCK1 ACTN4 CAVIN1 NEXN	3.06e-06	200	89	6	2bc7f462a551292de2501028164573935232f899
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TET2 BPTF SMCHD1 ASH1L ROCK1 TRIM22	3.06e-06	200	89	6	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	390C-Fibroblasts-Fibroblast-K_(Pericytes)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CKB MYL9 ROCK1 ACTN4 CAVIN1 NEXN	3.06e-06	200	89	6	8b80a65b69b36ed405214564b939452c90aa40d6
ToppCell	343B-Epithelial_cells-Epithelial-E_(AT2)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	ARHGEF35 CCDC9B PDE4C MYH14 NBPF10	1.08e-05	145	89	5	80684ec249fa445c1b35f94608a4a6824d53f2d9
ToppCell	343B-Epithelial_cells-Epithelial-E_(AT2)\|343B / Donor, Lineage, Cell class and subclass (all cells)	ARHGEF35 CCDC9B PDE4C MYH14 NBPF10	1.08e-05	145	89	5	cb534333fba44b241b14fb0d7b74e843f4e7f9f8
ToppCell	TCGA-Uterus-Primary_Tumor-Uterine_Carcinoma-Uterine_Carcinosarcoma-3\|TCGA-Uterus / Sample_Type by Project: Shred V9	ANKRD35 FAT2 ARHGEF35 TRIM22 TBC1D9	1.91e-05	163	89	5	d64dd39b077105c73e570ccef70f0e74a2c586ac
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CCDC9B ZSCAN30 USP25 ANKS4B RIOK2	2.14e-05	167	89	5	881f64db8dea3faa7588bf04d87c20924a4e5952
ToppCell	droplet-Liver-HEPATOCYTES-1m-Lymphocytic-NK/T\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP250 JAKMIP1 USP54 SNAPC4 CCDC136	2.40e-05	171	89	5	2e7cc311005958af52f39ca6c310c85b43a85aaf
ToppCell	droplet-Liver-HEPATOCYTES-1m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP250 JAKMIP1 USP54 SNAPC4 CCDC136	2.40e-05	171	89	5	4b599f953c8e5b947b2c8bbbf7fe6f9dc388e336
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-CX3CR1+_CD8_Tmem\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A3 SYNE1 SMCHD1 JAKMIP1 FYN	2.75e-05	176	89	5	6b06da40eb97ea2db09f3a769494738b3e5fe3fa
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYH1 CCDC9B PKD2L2 SNAP25 SBK2	2.83e-05	177	89	5	8abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNE1 SMCHD1 TUT7 ASH1L DIAPH1	2.91e-05	178	89	5	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	AT1_cells-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	CAPN9 CCDC9B MYL9 NEXN ABCA7	3.07e-05	180	89	5	e1964002681f80d8d62406b6ee52a01e1829ccf2
ToppCell	droplet-Kidney-nan-18m-Epithelial-Stroma____kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN9 COL6A3 MYL9 CAVIN1 NEXN	3.07e-05	180	89	5	b6f44fdedc33b7d93b0074e8e9c8cc32009d4c4d
ToppCell	droplet-Tongue-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BPTF ASH1L DIAPH1 ROCK1 ACTN4	3.77e-05	188	89	5	d62cc37e86b7b186e53aeb7f421c4e5ee28f23bd
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CKB ANO4 COL6A3 MYL9 NEXN	3.77e-05	188	89	5	293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	MYL2 DIAPH1 ACTN4 USP54 NEXN	3.87e-05	189	89	5	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BPTF COL6A3 KLHL5 G3BP2 FYN	3.97e-05	190	89	5	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	Mesenchymal_cells-Smooth_muscle\|World / Lineage and Cell class	CKB PDE4C MYL9 CAVIN1 NEXN	3.97e-05	190	89	5	5aa62a363a25f4a110136263b21289a11e8c1e6d
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANO4 COL6A3 MYL9 SYNE1 NEXN	4.07e-05	191	89	5	08042952431ca1a6fd7dfc13f36eb28643979598
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANO4 COL6A3 MYL9 SYNE1 NEXN	4.07e-05	191	89	5	7853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCLO JAKMIP1 SNAP25 CHGB ADD2	4.17e-05	192	89	5	fe9297cb65234d9f511bab1a5dbf2679d5a4cd15
ToppCell	E15.5-Mesenchymal-myocytic_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CKB COL6A3 MYL9 SYNE1 NEXN	4.27e-05	193	89	5	3316d6a39abb6a518d45b846254325fc7a8b2035
ToppCell	E15.5-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CKB COL6A3 MYL9 SYNE1 NEXN	4.27e-05	193	89	5	e787e618f6e8a1e22be366ce606bf78831b60a90
ToppCell	Posterior_cortex-Neuronal\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MYO9A G3BP2 SNAP25 HERC1 ADD2	4.27e-05	193	89	5	b4989e3436e84dbec3789b46057e0f7a0ebf09d4
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANO4 MYH1 COL6A3 MYL9 NEXN	4.38e-05	194	89	5	8fae8061b350336299aa81f378e07deadbd55123
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCLO JAKMIP1 SNAP25 CHGB ADD2	4.38e-05	194	89	5	15224fb3e7ca5bd1fb8c41f8275842f737014095
ToppCell	Hippocampus-Neuronal\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PDE4A PCLO SNAP25 HERC2 HERC1	4.38e-05	194	89	5	8aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANO4 MYH1 COL6A3 MYL9 NEXN	4.38e-05	194	89	5	4d7d24390fdb379f943ddcc70a63f23955e10163
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKB PCLO ASH1L ARFGEF1 HERC1	4.49e-05	195	89	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	(1)_T_cells-(1)_T_CD4_naive\|(1)_T_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)	BPTF SMCHD1 ASH1L RBM6 ADD2	4.49e-05	195	89	5	d3fa551bc6f5ee5890af1040415e61ecd5d46201
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKB PCLO ASH1L ARFGEF1 HERC1	4.49e-05	195	89	5	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	CV-Moderate-6\|CV / Virus stimulation, Condition and Cluster	BPTF PDE4A NBPF10 ROCK1 JAKMIP1	4.60e-05	196	89	5	7bced0cc2112697593c478fa291b8ed3941fb811
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-myocytic\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CKB COL6A3 MYL9 CAVIN1 NEXN	4.60e-05	196	89	5	20dc9b25ecc23b6e6e52bbab8b5a404f3245ca37
ToppCell	Brain_organoid-organoid_Velasco_nature-6_mon-Neuronal-CPNs\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	PCLO LRRC7 JAKMIP1 SNAP25 CHGB	4.60e-05	196	89	5	c9e7ac34993c873de4f198cdae77dcf099731532
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A3 MYL9 LRRC7 CAVIN1 NEXN	4.71e-05	197	89	5	398a66c06df63567b176ab2cc85e27837e94d0d9
ToppCell	ASK452-Epithelial-Type_1\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	MYL9 CAVIN1 USP54 NEXN ABCA7	4.71e-05	197	89	5	dc0a6dca4af6b216357b06f67203274f8b2a8bb0
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CKB COL6A3 MYL9 CAVIN1 NEXN	4.71e-05	197	89	5	94a7270ea6d4b586f58875c9e4071ce0f683ef7e
ToppCell	mild-Lymphocytic-CD8_T_cells\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	SYNE1 DIAPH1 ACTN4 JAKMIP1 FYN	4.71e-05	197	89	5	8b0e4012e25641c3bcd3e9911031e43d9dbbff21
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Neuronal-PNs\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	PCLO LRRC7 JAKMIP1 SNAP25 CHGB	4.71e-05	197	89	5	10e72b425a2bcba35e63a5b074d3dedcd49a762e
ToppCell	Tracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CKB MYL9 SYNE1 SNAP25 NEXN	4.71e-05	197	89	5	ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCell	AT1-AT2_cells\|World / lung cells shred on cell class, cell subclass, sample id	CAPN9 MYL9 CAVIN1 NEXN ABCA7	4.83e-05	198	89	5	a5b3617ea2ed4bffba59edcf6284799c2b3bbb29
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Neuronal\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	PCLO LRRC7 JAKMIP1 SNAP25 CHGB	4.83e-05	198	89	5	076c862f2a723f0361749377561cae902068b1a0
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ANO4 ANKRD35 PCLO SNAP25 CHGB	4.83e-05	198	89	5	d6812494874be0c14361ac2ac3e418b335bb8f55
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-cortical_neurons_1\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	PCLO LRRC7 JAKMIP1 SNAP25 CHGB	4.83e-05	198	89	5	d81f35c0066558ff96dd06f58fca72cd82e681e8
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-Neuronal\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	PCLO LRRC7 JAKMIP1 SNAP25 CHGB	4.83e-05	198	89	5	a0032e3ed259e39324a659490b9d340c5d9ba0fc
ToppCell	(00)_Basal-(2)_GFP_FOXI1\|(00)_Basal / shred by cell type by condition	BPTF KLHL5 MYL9 ROCK1 FYN	4.94e-05	199	89	5	19674e1eaeb51e4196d847cb62aa437c852951d3
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CKB ANO4 COL6A3 SYNE1 NEXN	4.94e-05	199	89	5	e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCell	(04)_Interm._basal>secr.-(2)_GFP_FOXI1\|(04)_Interm._basal>secr. / shred by cell type by condition	BPTF KLHL5 RLIM ROCK1 FYN	4.94e-05	199	89	5	53ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	BPTF KLHL5 RLIM ROCK1 FYN	4.94e-05	199	89	5	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	PCLO LRRC7 JAKMIP1 SNAP25 CHGB	4.94e-05	199	89	5	0cd3e4e0fba000c996feaf012ff32198e1048c9d
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Goblet\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CAPN9 GALE PDE4C MYH14 ABCA7	4.94e-05	199	89	5	e03bdc7cb825e287f41b834ec6061d23c1c03b04
ToppCell	(05)_Secretory-(2)_GFP_FOXI1\|(05)_Secretory / shred by cell type by condition	BPTF KLHL5 RLIM ROCK1 FYN	4.94e-05	199	89	5	d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3_mon-Neuronal\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	PCLO LRRC7 JAKMIP1 SNAP25 CHGB	4.94e-05	199	89	5	1029f3458b7fda464aa0e7ef06e081e2618c1388
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3_mon-Neuronal-PNs\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	PCLO LRRC7 JAKMIP1 SNAP25 CHGB	4.94e-05	199	89	5	8a04398653a1794921d73a6a950c1fb6fdf68c85
ToppCell	(01)_IL1RL1+-(2)_GFP_FOXI1\|(01)_IL1RL1+ / shred by cell type by condition	BPTF KLHL5 MYL9 ROCK1 FYN	4.94e-05	199	89	5	a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_basal-Suprabasal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FAT2 ARHGEF35 GALE PDE4C MYH14	5.06e-05	200	89	5	5f0f67958c9635db53e61f8370a92da6ea3e80fe
ToppCell	Striatum-Neuronal\|Striatum / BrainAtlas - Mouse McCarroll V32	G3BP2 PCLO SNAP25 CHGB HERC1	5.06e-05	200	89	5	c888fd487990cad482a4ca47601cdebc0ca3f3ce
ToppCell	mild-CD8+_Tem\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE1 SMCHD1 JAKMIP1 FYN TRIM22	5.06e-05	200	89	5	d8aec4904c9420b8f9d7508658ba1e36c66cdfcc
ToppCell	343B-Fibroblasts-Fibroblast-K_(Pericytes)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CKB MYL9 ACTN4 CAVIN1 NEXN	5.06e-05	200	89	5	4fb6fd703aca9a992924245105ad99163146a415
ToppCell	cellseq2-Mesenchymal\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CKB COL6A3 MYL9 CAVIN1 NEXN	5.06e-05	200	89	5	6b558cce0d6047c7e85f428adff80c5ca3084ea4
ToppCell	COVID-19-COVID-19_Convalescent-Lymphocyte-T/NK-CD8+_Tem\|COVID-19_Convalescent / Disease, condition lineage and cell class	SYNE1 ACTN4 JAKMIP1 FYN MYL12B	5.06e-05	200	89	5	7c8a5465b478f430495942151c36020023d9bac9
ToppCell	mLN-Macrophage-LYVE1_Macrophage\|Macrophage / Region, Cell class and subclass	BPTF PDE4A SMCHD1 RBM6 HERC1	5.06e-05	200	89	5	e3c15e0e1c2602b0cc9ab8cc50c978d265350c94
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	CKB ANO4 COL6A3 SYNE1 NEXN	5.06e-05	200	89	5	9d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	SYNE1 PCLO LRRC7 SNAP25 HERC1	5.06e-05	200	89	5	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CKB ANO4 COL6A3 SYNE1 NEXN	5.06e-05	200	89	5	87827041663013f5e7273168dc8709d69840e7ce
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-AT1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CKB CAPN9 MYL9 MYH14 ABCA7	5.06e-05	200	89	5	c6f211bbadd0c9be776c58807249e06764df47dc
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Cortical_neuron\|3m / Sample Type, Dataset, Time_group, and Cell type.	PCLO LRRC7 JAKMIP1 SNAP25 CHGB	5.06e-05	200	89	5	c248233b004f8ef0bab3c65ecfe295887966f2ee
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CKB ANO4 COL6A3 SYNE1 NEXN	5.06e-05	200	89	5	c596a53c0b63c9deaac7d99fcbdd94ecfa96b86c
ToppCell	distal-3-Epithelial-Alveolar_Epithelial_Type_1\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CKB CAPN9 MYL9 MYH14 ABCA7	5.06e-05	200	89	5	ff64454a08ae8d4cc6e8f0392558460020844bbc
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CKB ANO4 COL6A3 SYNE1 NEXN	5.06e-05	200	89	5	8988f113708eef7d9d2a6a6c1bcfd7c8f9804d3e
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CKB ANO4 COL6A3 SYNE1 NEXN	5.06e-05	200	89	5	08bf8c00eee6468215edb3611296bfc8784c4d56
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-AT1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CKB CAPN9 MYL9 MYH14 ABCA7	5.06e-05	200	89	5	5f7e8d8b05c90a10313775f9f126eb4ab0fe4f67
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic\|LPS_only / Treatment groups by lineage, cell group, cell type	CKB ANO4 COL6A3 SYNE1 NEXN	5.06e-05	200	89	5	02cae2c296a13ad4cbb53bca7a86d64629d67d66
ToppCell	distal-Epithelial-Alveolar_Epithelial_Type_1-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CKB CAPN9 MYL9 MYH14 ABCA7	5.06e-05	200	89	5	ccd0edd483728279fe15d64be3a39e8636bf2eeb
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	BPTF SMCHD1 G3BP2 DIAPH1 ROCK1	5.06e-05	200	89	5	7dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX-AT1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	CKB CAPN9 MYL9 MYH14 ABCA7	5.06e-05	200	89	5	e3a80626941363bfc9d97ef906d38c97080aecb1
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Neuronal\|6m / Sample Type, Dataset, Time_group, and Cell type.	PCLO LRRC7 JAKMIP1 SNAP25 CHGB	5.06e-05	200	89	5	cedbc47b1defb5973cf7ab6baaa2d6f2fd481f88
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Neuronal-Cortical_neuron\|6m / Sample Type, Dataset, Time_group, and Cell type.	PCLO LRRC7 JAKMIP1 SNAP25 CHGB	5.06e-05	200	89	5	6f7ff0533339fcc9d316f2c77334a79c1409ec4f
ToppCell	343B-Fibroblasts-Fibroblast-K_(Pericytes)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CKB MYL9 ACTN4 CAVIN1 NEXN	5.06e-05	200	89	5	b50de1f8c8f598e281951e4587f2d96c11aac836
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-cortical_neurons_2\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	PCLO LRRC7 JAKMIP1 SNAP25 CHGB	5.06e-05	200	89	5	0cb0755a101ec655359d051d6a8807408d727c55
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Reln_(Cajal-Retzius)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ANKRD35 PKD2L2 DLEC1 DNAH1	8.65e-05	116	89	4	1bfd3b0ec4cb5a04c6dfe7861a544eb277e473a3
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Reln_(Cajal-Retzius)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ANKRD35 PKD2L2 DLEC1 DNAH1	8.65e-05	116	89	4	a3dcd18807d14e207438f321be62797384fd3907
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ANKRD35 PKD2L2 DLEC1 DNAH1	8.65e-05	116	89	4	685484ea4cbefb5aff5f0cd999fdfadc5a5676e1
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	FAT2 ASH1L HERC1 GOLGA1	1.05e-04	122	89	4	1ed865f0ecfe304fb86313ff51c04e9052357270
ToppCell	TCGA-Peripheral_Nervous_System-Primary_Tumor-Paraganglioma-Paraganglioma-3\|TCGA-Peripheral_Nervous_System / Sample_Type by Project: Shred V9	KMT2D CPSF6 SYNE1 CHGB	1.55e-04	135	89	4	ac20133d4a36f48338b45bffb13e842cb66f83ad
ToppCell	3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	EVC2 SYNE1 SMCHD1 HERC1	1.55e-04	135	89	4	ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_immature_-_proliferative\|E16.5-samps / Age Group, Lineage, Cell class and subclass	CKB MYL9 DEPDC5 USP54	1.60e-04	136	89	4	96370f0e3abf1c9ec7a91595b5d0f97ac2ab4b78
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	KMT2D SMCHD1 ASH1L FYN	2.15e-04	147	89	4	94998bc40f5c08295cfe3bdcbe43f13b1e564b3d
Computational	Genes upregulated in subsets of cells of a given type within various tumors	BPTF SYNE1 SMCHD1 ROCK1 FYN	4.27e-06	49	54	5	GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_CHROMATIN
Drug	NSC339663	MYH1 MYH4 MYL2 MYL9 MYO9A MYH14 SYNE1 ROCK1 ACTN4 CAVIN1 SNAP25 MYL12B	2.32e-10	250	88	12	CID000003892
Drug	formycin triphosphate	MYH1 MYH4 MYL2 MYL9 MYO9A MYH14 MYL12B	1.02e-09	51	88	7	CID000122274
Drug	purealin	MYH1 MYH4 MYL2 MYL9 MYO9A MYH14 MYL12B	2.59e-09	58	88	7	CID006419303
Drug	blebbistatin	MYH1 MYH4 MYL2 MYL9 MYO9A MYH14 ROCK1 MYL12B	1.63e-08	116	88	8	CID003476986
Drug	B0683	MYH1 MYH4 MYL2 MYL9 MYO9A MYH14 ROCK1 MYL12B	1.74e-08	117	88	8	CID006398969
Drug	S-(-)-Etomoxir	MYH1 MYH4 MYL2 MYL9 MYO9A MYH14 MYL12B	1.21e-07	100	88	7	CID000060765
Drug	fast white	MYH1 MYH4 MYL2 MYL9 MYL12B	5.84e-07	42	88	5	CID000024008
Drug	Triflusal [322-79-2]; Down 200; 16.2uM; HL60; HG-U133A	R3HDM4 MYH14 TNIP2 G3BP2 DIAPH1 ROCK1 ACTN4 SNAP25	9.69e-07	197	88	8	1717_DN
Drug	clenbuterol	MYH1 MYH4 MYL2 MYL9 MYO9A MYH14 MYL12B	1.32e-06	142	88	7	CID000002783
Drug	eye gene	MYH1 MYH4 EVC2 MYL2 MYL9 MYO9A MYH14 TNIP2 ROCK1 MYL12B	1.63e-06	369	88	10	CID000004782
Drug	AC1L1IZ2	MYH1 MYH4 MYL2 MYL9 MYO9A MYH14 ROCK1 RIOK2 MYL12B	2.72e-06	304	88	9	CID000004795
Drug	NSC107658	MYH1 MYH4 MYL2 MYL9 MYO9A MYH14 TNIP2 ROCK1 MYL12B	2.87e-06	306	88	9	CID000002919
Drug	N-ethylmaleimide	CKB MYH1 MYH4 MYL2 MYL9 STX18 MYO9A MYH14 MTIF2 SNAP25 MYL12B	4.40e-06	511	88	11	CID000004362
Drug	oxovanadium	MYH1 MYH4 MYL2 MYL9 ARFGEF1 MYL12B	7.20e-06	120	88	6	CID000024411
Drug	Fluspirilen [1841-19-6]; Up 200; 8.4uM; HL60; HT_HG-U133A	PDE4C PCLO GRAMD2B ASAP3 SNAP25 TBC1D9 ADD2	1.00e-05	193	88	7	3086_UP
Drug	AC1NSVQS	MYL2 MYL9 MYL12B	1.20e-05	12	88	3	CID005317517
Drug	MAPTAM	MYL2 MYL9 ROCK1 MYL12B	1.25e-05	37	88	4	CID000123719
Drug	12-deoxyphorbol 13-isobutyrate	MYL2 MYL9 ROCK1 MYL12B	1.55e-05	39	88	4	CID000107855
Drug	hydroxystearic acid	MYL9 TNIP2 HERC2 TP53BP2	2.08e-05	42	88	4	CID000007789
Drug	SM-2	MYH1 MYH4 MYL2 MYL9 MYL12B	2.21e-05	87	88	5	CID000486033
Drug	trifluoperazine	MYH1 MYH4 MYL2 MYL9 MYO9A MYH14 MYL12B TBC1D9	3.69e-05	324	88	8	CID000005566
Drug	1 SA	MYL2 MYL9 MYL12B	6.06e-05	20	88	3	CID011987857
Drug	K-Cl	MYH1 MYH4 MYL2 MYL9 MYO9A MYH14 ROCK1 SNAP25 CHGB MYL12B	6.70e-05	567	88	10	CID000004873
Drug	MgCl2	MYH1 MYH4 MYL2 MYL9 MYO9A MYH14 DLST MYL12B	6.88e-05	354	88	8	CID000024584
Drug	AC1NAQNU	MYL2 SYNE1 MYL12B	7.06e-05	21	88	3	CID004456135
Drug	trichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A	PDE4A ASAP3 CAVIN1 SNAPC4 FYN ABCA7	8.53e-05	186	88	6	7499_UP
Drug	aescine	MYL2 MYL9 ROCK1 MYL12B	8.61e-05	60	88	4	CID004555259
Drug	Piclamilast	PDE4A PDE4C	8.82e-05	4	88	2	DB01791
Drug	arachidonic acid sodium salt; Down 200; 10uM; MCF7; HG-U133A	CAPN9 COL6A3 TCHH CAVIN1 DLEC1 CHGB	1.17e-04	197	88	6	441_DN
Drug	Sulfapyridine [144-83-2]; Up 200; 16uM; PC3; HT_HG-U133A	PDE4A SMCHD1 ASAP3 SNAPC4 FYN ABCA7	1.20e-04	198	88	6	7151_UP
Drug	Ofloxacin [82419-36-1]; Up 200; 11uM; MCF7; HT_HG-U133A	TCHH PCLO ACTN4 CAVIN1 ABCA7 ADD2	1.24e-04	199	88	6	2302_UP
Drug	4-chloroaniline	MYH1 MYH4 MYL2 MYL9 ROCK1 MYL12B	1.34e-04	202	88	6	CID000007812
Drug	Ibudilast	PDE4A PDE4C	1.47e-04	5	88	2	DB05266
Drug	1,7-naphthyridine	PDE4A PDE4C	1.47e-04	5	88	2	CID000009209
Drug	AC1LADJ6	MYH1 MYH4 MYL2 MYL9 MYL12B	1.51e-04	130	88	5	CID000486032
Drug	caged ATP	MYL2 MYL9 DLST MYL12B	1.57e-04	70	88	4	CID000123806
Disease	Malignant neoplasm of breast	MYH1 KMT2D SYNE1 G3BP2 EFCAB13 LRRC7 CAVIN1 DLEC1 USP54 HERC2 TP53BP2 EPG5	7.30e-05	1074	87	12	C0006142
Disease	familial hypertrophic cardiomyopathy (is_implicated_in)	MYL2 MYL9	3.05e-04	9	87	2	DOID:0080326 (is_implicated_in)
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH1 MYH4	3.81e-04	10	87	2	DOID:0110454 (implicated_via_orthology)
Disease	Peripheral T-Cell Lymphoma	TET2 FYN	3.81e-04	10	87	2	C0079774
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH1 MYH4	3.81e-04	10	87	2	DOID:0111269 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH1 MYH4	3.81e-04	10	87	2	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH1 MYH4	3.81e-04	10	87	2	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH1 MYH4	3.81e-04	10	87	2	DOID:3429 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH1 MYH4	3.81e-04	10	87	2	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH1 MYH4	3.81e-04	10	87	2	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH1 MYH4	3.81e-04	10	87	2	DOID:0111596 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH1 MYH4	5.56e-04	12	87	2	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH1 MYH4	5.56e-04	12	87	2	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH1 MYH4	6.56e-04	13	87	2	DOID:397 (implicated_via_orthology)
Disease	coronary artery disease	CKB TET2 COL6A3 MYL2 EFCAB13 LRRC7 CAVIN1 DLEC1 JAKMIP1 FYN EPG5	7.63e-04	1194	87	11	EFO_0001645
Disease	distal arthrogryposis (implicated_via_orthology)	MYH1 MYH4	8.80e-04	15	87	2	DOID:0050646 (implicated_via_orthology)
Disease	Colorectal Carcinoma	TET2 EVC2 CCDC9B CFAP77 SYNE1 ASAP3 ARFGEF1 JAKMIP1	1.11e-03	702	87	8	C0009402
Disease	muscular dystrophy (is_implicated_in)	COL6A3 SYNE1	1.14e-03	17	87	2	DOID:9884 (is_implicated_in)
Disease	Congenital Myasthenic Syndromes, Presynaptic	MYO9A SNAP25	1.42e-03	19	87	2	C0751884
Disease	Primary familial hypertrophic cardiomyopathy	MYL2 NEXN	1.91e-03	22	87	2	cv:C0949658
Disease	response to bronchodilator, FEV/FEC ratio	ANO4 TET2 FAT2 ARHGEF5 TNIP2 LRRC7 DLEC1 MYL12B	1.91e-03	766	87	8	EFO_0004713, GO_0097366
Disease	Intellectual Disability	BPTF GALE SYNE1 RLIM ASH1L DIAPH1	2.10e-03	447	87	6	C3714756
Disease	response to radiation	PDE4A SMCHD1 EPG5	2.27e-03	88	87	3	GO_0009314
Disease	Squamous cell carcinoma of esophagus	FAT2 KMT2D DLEC1	2.82e-03	95	87	3	C0279626
Disease	prostate carcinoma, breast carcinoma, ovarian carcinoma	TET2 ARHGEF5	2.88e-03	27	87	2	EFO_0000305, EFO_0001075, EFO_0001663
Disease	hair shape measurement	TCHH ADD2	2.88e-03	27	87	2	EFO_0007824
Disease	Sezary Syndrome	TET2 KMT2D	2.88e-03	27	87	2	C0036920
Disease	retinitis pigmentosa (implicated_via_orthology)	CEP250 EPG5	2.88e-03	27	87	2	DOID:10584 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
DAREKQGQQMREAQF	ARID3B	26	Q8IVW6
QMAQARRTNVDEDFI	EPG5	781	Q9HCE0
GEVVSEQEFRNRMIE	ASH1L	2176	Q9NR48
GEVAQDMQRERRIFQ	ASAP3	176	Q8TDY4
ENERLGVVRDSMFQN	CFAP77	46	Q6ZQR2
TQAQLEERQAEMEGA	CAVIN1	71	Q6NZI2
EERQAEMEGAVQSIQ	CAVIN1	76	Q6NZI2
AVDFDVRVDTQDQGM	ARFGEF1	1656	Q9Y6D6
QEQVQDVMLGRQGER	ARHGEF5	276	Q12774
VENDRQGEAEFNRIM	ACTN4	801	O43707
QEQVQDVMLGRQGER	ARHGEF35	276	A5YM69
AQAAEQERQASEMRG	ANKRD35	886	Q8N283
QERQASEMRGRSEQF	ANKRD35	891	Q8N283
EVFERNIRAEGLQME	ANO4	136	Q32M45
EDMRVQLNVFDEQGE	DIAPH1	356	O60610
FINGDVIMEDFNERN	BPTF	1591	Q12830
AMIREADVDQDGRVN	CALML5	121	Q9NZT1
VADNERMFDVLQRFG	TP53BP2	56	Q13625
NQAMADAFERLGDRQ	ABCA7	1706	Q8IZY2
DVMDLQFFDQERIVA	NUP43	76	Q8NFH3
DFMNRSGEEQERVLR	R3HDM4	121	Q96D70
FEEARRQMVNEDEEN	NEXN	281	Q0ZGT2
MDQNRDGFIDKNDLR	MYL2	36	P10916
RDEDGVQMTAQQVFE	DEPDC5	786	O75140
RRDEMDELEGFQQQE	GOLGA1	166	Q92805
LDEDNMEFQVGDRIV	MTIF2	696	P46199
IEMEQRLEQGQAIDD	CKB	361	P12277
EQRQQRMTVAFEFED	LRRC7	451	Q96NW7
EFDEQVAAVREGMAR	HERC2	4641	O95714
GVEDDQMAQIVERLF	HERC1	1971	Q15751
EIQEDRRQAEQGGMA	CCDC9B	86	Q6ZUT6
RQAQQDRDEMADEVA	MYH14	1721	Q7Z406
EAFNMIDQNRDGFID	MYL9	36	P24844
RQEEENGFMQQKGRE	PCLO	1976	Q9Y6V0
QVRAMDADRGVNAEV	FAT2	1576	Q9NYQ8
TDRIMAEFFQQGDRE	PDE4A	606	P27815
AEFFQQGDRERERGM	PDE4A	611	P27815
TDRIMAEFFQQGDRE	PDE4C	561	Q08493
ERVQRMEAQEGGFAQ	EVC2	951	Q86UK5
GVQDQHMDERDVRRF	JAKMIP1	276	Q96N16
IQGEMEDIIQEARNA	MYH1	1741	P12882
GQRNVMEVFREEEED	ANKS4B	226	Q8N8V4
AAMFTNDVREARQEE	KLHL5	246	Q96PQ7
RVFMEEQRQRQEEEA	PIPSL	706	A2A3N6
VIRNVEAMNFADIER	DLST	331	P36957
EFEEMDILDQGALQR	GALE	61	Q14376
AQQQRVERFMFEGVE	DNAH1	1656	Q9P2D7
EAEFEEIMNRNRAIS	CPSF6	411	Q16630
MTREADEDAVQFANR	GPAT4	391	Q86UL3
RGDMEQNDSDNRRII	G3BP2	311	Q9UN86
NNREVLEQVERGYRM	FYN	471	P06241
EGVNQDTFGRMRDVV	COL6A3	2411	P12111
ELSALRQDMQEAQGE	CEP250	1081	Q9BV73
SRNENGMVELDDFVN	EFCAB13	501	Q8IY85
FSDLDGVVQQRRQDM	GRAMD2B	251	Q96HH9
QRFRALFEQVAGEDM	CAPN9	521	O14815
ENERVMSQAGVQDLE	DLEC1	166	Q9Y238
NDFRDEQIGQLQELM	SDHAF3	91	Q9NRP4
ELQQGQEAARALEDM	SBK2	31	P0C263
FERRDNMNDNFLEGE	CHGB	536	P05060
AQVEVFRRQDAQRGM	POLRMT	961	O00411
EMAEREERQQQVAED	CNTROB	506	Q8N137
EAFNMIDQNRDGFID	MYL12B	36	O14950
QEAMSAAFRGQREEV	HSPBP1	76	Q9NZL4
QDREHSGMNVNRREE	RBM6	301	P78332
LNGQEQRMKIDREFA	SMCHD1	546	A6NHR9
EEIAGFEDRLNNLQM	SYNE1	3971	Q8NF91
VLEQQRVGFAFDMDE	NBPF10	906	Q6P3W6
LEQQRVGFAVDMDEI	NBPF10	1151	Q6P3W6
EQQRVGFAVDMDEIE	NBPF10	1396	Q6P3W6
RLQDSQGMERDQEAL	GUCY1B2	121	O75343
IQGEMEDIVQEARNA	MYH4	1741	Q9Y623
DLDSMLRNEEVQFGQ	RIOX1	246	Q9H6W3
DMGNEIDTQNRQIDR	SNAP25	166	P60880
FNGEMEQEADRINLQ	ADD2	261	P35612
ELLEDQRRMQEEQGQ	CCDC136	566	Q96JN2
EQLRRQEGGAAEAQM	TNIP2	76	Q8NFZ5
QEGGAAEAQMRQEIE	TNIP2	81	Q8NFZ5
QESQAFQERDGRMVA	ZSCAN30	176	Q86W11
TERDQIDQDAQIFMR	STX18	91	Q9P2W9
EIQMFEQENQRLIGE	STX18	231	Q9P2W9
EQIDNLAMRSFGEND	RLIM	551	Q9NVW2
IAMRQLLDNEGFEQD	TBC1D9	251	Q6ZT07
GEDREVNNGLIIMNE	USP25	946	Q9UHP3
REGFDENEIQNAEQM	PKD2L2	551	Q9NZM6
EFRPFRDEENVGAMN	RIOK2	461	Q9BVS4
EGQMRELQDQLEAEQ	ROCK1	836	Q13464
NREQQEELMRDLAGS	SNAPC4	111	Q5SXM2
NFGDVVPRRDFEMQE	TSNAXIP1	251	Q2TAA8
RLTINQREDEDGMAN	TUT7	861	Q5VYS8
NVAAIREIMEERFGQ	TET2	1156	Q6N021
KFMEDEQQLRRQEGQ	TCHH	1596	Q07283
GFNEMRVILDNEEQR	TRIM22	186	Q8IYM9
TFQDEQRFQLGIMDD	USP54	106	Q70EL1
GRQEDEREVAEFMEQ	KMT2D	5001	O14686
MNINDGGRRRFEDNE	MYO9A	1	B2RTY4