Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninhibitory MHC class I receptor activity

LILRA2 LILRA4 LILRB4

2.17e-0612443GO:0032396
GeneOntologyMolecularFunctionMHC class Ib protein binding

KIR3DL3 LILRA2 KIR3DL2

5.48e-0616443GO:0023029
GeneOntologyMolecularFunctionMHC class I receptor activity

LILRA2 LILRA4 LILRB4

7.96e-0618443GO:0032393
GeneOntologyMolecularFunctionMHC class Ib receptor activity

KIR3DL3 LILRA2 KIR3DL2

9.44e-0619443GO:0032394
GeneOntologyMolecularFunctionimmune receptor activity

KIR3DL3 LILRA2 KIR3DL2 LILRA4 LILRB4

3.03e-05165445GO:0140375
GeneOntologyMolecularFunctioncalcium-independent phospholipase A2 activity

PLB1 PLA2G15

1.69e-049442GO:0047499
GeneOntologyMolecularFunctionphosphatidyl phospholipase B activity

PLB1 PLA2G15

2.58e-0411442GO:0102545
GeneOntologyMolecularFunctionIgM binding

LILRA2 LILRA4

2.58e-0411442GO:0001791
GeneOntologyMolecularFunctionMHC protein binding

KIR3DL3 LILRA2 KIR3DL2

2.83e-0458443GO:0042287
GeneOntologyMolecularFunctionphosphotransferase activity, for other substituted phosphate groups

CEPT1 SGMS1

1.07e-0322442GO:0016780
GeneOntologyMolecularFunctionlysophospholipase activity

PLB1 PLA2G15

1.86e-0329442GO:0004622
GeneOntologyMolecularFunctionimmunoglobulin binding

LILRA2 LILRA4

2.85e-0336442GO:0019865
GeneOntologyMolecularFunctionphospholipase A2 activity

PLB1 PLA2G15

3.01e-0337442GO:0004623
GeneOntologyBiologicalProcessimmune response-regulating signaling pathway

LAIR2 KIR3DL3 KIR2DL5A LILRA2 KIR3DX1 KIR2DL5B KIR3DL2 LILRA4 LILRB4

8.70e-06615479GO:0002764
GeneOntologyBiologicalProcessphosphatidylethanolamine catabolic process

PLB1 PLA2G15

3.04e-054472GO:0046338
GeneOntologyBiologicalProcessphosphatidylethanolamine metabolic process

PLB1 CEPT1 PLA2G15

4.31e-0530473GO:0046337
GeneOntologyCellularComponentFc-epsilon receptor I complex

LILRA2 LILRA4

1.69e-049462GO:0032998
GeneOntologyCellularComponentFc receptor complex

LILRA2 LILRA4

3.08e-0412462GO:0032997
Domainig

KIR3DL3 KIR2DL5A LILRA2 KIR3DL2 LILRA4 LILRB4

6.00e-06190456PF00047
DomainImmunoglobulin

KIR3DL3 KIR2DL5A LILRA2 KIR3DL2 LILRA4 LILRB4

6.00e-06190456IPR013151
DomainIg_2

LAIR2 LILRA2 LILRA4 LILRB4

2.83e-0573454PF13895
DomainIG

LAIR2 KIR3DL3 KIR2DL5A LILRA2 KIR3DL2 LILRA4 LILRB4

6.09e-05421457SM00409
DomainIg_sub

LAIR2 KIR3DL3 KIR2DL5A LILRA2 KIR3DL2 LILRA4 LILRB4

6.09e-05421457IPR003599
DomainA1B_glyco/leuk_Ig-like_rcpt

LILRA2 LILRA4

8.46e-056452IPR016332
DomainIG_LIKE

LAIR2 KIR3DL3 KIR2DL5A LILRA2 KIR3DL2 LILRA4 LILRB4

1.59e-04491457PS50835
DomainTIL

MUC5B SSPOP

3.69e-0412452PF01826
DomainC8

MUC5B SSPOP

3.69e-0412452PF08742
DomainUnchr_dom_Cys-rich

MUC5B SSPOP

4.35e-0413452IPR014853
DomainC8

MUC5B SSPOP

4.35e-0413452SM00832
DomainTIL_dom

MUC5B SSPOP

5.07e-0414452IPR002919
DomainVWFD

MUC5B SSPOP

6.67e-0416452PS51233
DomainVWD

MUC5B SSPOP

6.67e-0416452SM00216
DomainVWF_type-D

MUC5B SSPOP

6.67e-0416452IPR001846
DomainVWD

MUC5B SSPOP

6.67e-0416452PF00094
DomainCTCK_1

MUC5B SSPOP

8.47e-0418452PS01185
DomainVWC_out

MUC5B SSPOP

9.46e-0419452SM00215
DomainIg-like_dom

LAIR2 KIR2DL5A LILRA2 KIR3DL2 LILRA4 LILRB4

1.24e-03503456IPR007110
DomainIg-like_fold

LAIR2 KIR3DL3 KIR2DL5A LILRA2 KIR3DL2 LILRA4 LILRB4

1.39e-03706457IPR013783
DomainCys_knot_C

MUC5B SSPOP

1.64e-0325452IPR006207
DomainCTCK_2

MUC5B SSPOP

1.64e-0325452PS01225
DomainVWFC_1

MUC5B SSPOP

3.39e-0336452PS01208
DomainVWC

MUC5B SSPOP

3.78e-0338452SM00214
DomainVWFC_2

MUC5B SSPOP

3.78e-0338452PS50184
DomainVWF_dom

MUC5B SSPOP

4.60e-0342452IPR001007
Domain-

LAIR2 KIR2DL5A LILRA2 KIR3DL2 LILRA4 LILRB4

4.90e-036634562.60.40.10
PathwayREACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL

LAIR2 LILRA2 KIR3DL2 LILRA4 LILRB4

1.30e-04190375M8240
Pubmed

[Polymorphism of killer cell immunoglobulin-like receptors gene family in Zhejiang Han population].

KIR3DL3 KIR2DL5A KIR2DL5B KIR3DL2

5.74e-091648416403292
Pubmed

[Analysis of natural killer cell immunoglobulin-like receptor genes in Chinese].

KIR3DL3 KIR2DL5A KIR2DL5B KIR3DL2

7.50e-091748419218127
Pubmed

Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection.

KIR3DL3 KIR2DL5A KIR2DL5B KIR3DL2

7.50e-091748420878400
Pubmed

Killer cell immunoglobulin-like receptor gene diversity in the Tibetan ethnic minority group of China.

KIR3DL3 KIR2DL5A KIR2DL5B KIR3DL2

7.50e-091748420650299
Pubmed

Killer cell immunoglobulin-like receptor gene polymorphisms in patients with leukemia: possible association with susceptibility to the disease.

KIR3DL3 KIR2DL5A KIR2DL5B KIR3DL2

7.50e-091748419450876
Pubmed

Distribution of killer-cell immunoglobulin-like receptor genes in Eastern mainland Chinese Han and Taiwanese Han populations.

KIR3DL3 KIR2DL5A KIR2DL5B KIR3DL2

7.50e-091748419761533
Pubmed

Signatures of natural selection and coevolution between killer cell immunoglobulin-like receptors (KIR) and HLA class I genes.

KIR3DL3 KIR2DL5A KIR2DL5B KIR3DL2

9.63e-091848420200544
Pubmed

HLA and KIR frequencies in Sicilian Centenarians.

KIR3DL3 KIR2DL5A KIR2DL5B KIR3DL2

1.52e-082048420426625
Pubmed

Compound KIR-HLA genotype analyses in the Iranian population by a novel PCR-SSP assay.

KIR3DL3 KIR2DL5A KIR2DL5B KIR3DL2

1.52e-082048420193031
Pubmed

Distribution of KIR genes in the population of unrelated individuals homozygous for ancestral haplotype AH8.1 (HLA-A1B8DR3).

KIR3DL3 KIR2DL5A KIR2DL5B KIR3DL2

2.29e-082248420492596
Pubmed

Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis.

KIR3DL3 KIR2DL5A KIR2DL5B KIR3DL2

1.62e-073548419683555
Pubmed

Polymorphisms of killer cell immunoglobulin-like receptor gene: possible association with susceptibility to or clearance of hepatitis B virus infection in Chinese Han population.

KIR3DL3 KIR2DL5A KIR3DL2

2.06e-07948318074414
Pubmed

[Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia].

KIR3DL3 KIR2DL5A KIR3DL2

5.38e-071248317490516
Pubmed

Frequencies of killer immunoglobulin-like receptor genotypes influence susceptibility to spontaneous abortion.

KIR3DL3 KIR2DL5A KIR3DL2

8.88e-071448319875891
Pubmed

Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population.

KIR3DL3 KIR2DL5A KIR3DL2

8.88e-071448315896204
Pubmed

[Genotype and haplotype analysis of killer cell immunoglobulin-like receptors in ankylosing spondylitis].

KIR3DL3 KIR2DL5A KIR3DL2

8.88e-071448319489269
Pubmed

Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia.

KIR3DL3 KIR2DL5A KIR3DL2

8.88e-071448318945962
Pubmed

A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells.

LAIR2 LILRA2 LILRA4

1.11e-06154839144225
Pubmed

Killer cell immunoglobulin-like receptor gene diversity in a Caucasian population of southern Brazil.

KIR3DL3 KIR2DL5A KIR3DL2

1.11e-061548320082646
Pubmed

Inhibitory KIR and specific HLA-C gene combinations confer susceptibility to or protection against chronic hepatitis B.

KIR3DL3 KIR2DL5A KIR3DL2

1.11e-061548320643584
Pubmed

KIR genes polymorphism in Argentinean Caucasoid and Amerindian populations.

KIR3DL3 KIR2DL5A KIR3DL2

1.11e-061548317498266
Pubmed

Killer cell immunoglobulin-like receptor genotype and killer cell immunoglobulin-like receptor-human leukocyte antigen C ligand compatibility affect the severity of hepatitis C virus recurrence after liver transplantation.

KIR3DL3 KIR2DL5A KIR3DL2

1.11e-061548319326408
Pubmed

Disparate distribution of activating and inhibitory killer cell immunoglobulin-like receptor genes in patients with systemic lupus erythematosus.

KIR3DL3 KIR2DL5A KIR3DL2

1.11e-061548319926642
Pubmed

[Killer cell immunoglobin-like receptor and its ligand gene polymorphisms in Hunan Han patients with type 1 diabetes].

KIR3DL3 KIR2DL5A KIR3DL2

1.11e-061548320356536
Pubmed

Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada syndrome in Japanese individuals.

KIR3DL3 KIR2DL5A KIR3DL2

1.36e-061648319897003
Pubmed

Influence of activating and inhibitory killer immunoglobulin-like receptors on predisposition to recurrent miscarriages.

KIR3DL3 KIR2DL5A KIR3DL2

1.36e-061648319279038
Pubmed

No association of KIR genes with Behcet's disease.

KIR3DL3 KIR2DL5A KIR3DL2

1.36e-061648317868255
Pubmed

A study of the killer cell immunoglobulin-like receptor gene KIR2DS1 in a Caucasoid Brazilian population with psoriasis vulgaris.

KIR3DL3 KIR2DL5A KIR3DL2

1.36e-061648318643961
Pubmed

Distribution of killer cell immunoglobulin-like receptor (KIR) genotypes in patients with familial Mediterranean fever.

KIR3DL3 KIR2DL5A KIR3DL2

1.36e-061648319309280
Pubmed

Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Java, Kalimantan, Timor and Irian Jaya.

KIR3DL3 KIR2DL5A KIR3DL2

1.36e-061648319000141
Pubmed

Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Sumatra, Sulawesi and Moluccas Islands.

KIR3DL3 KIR2DL5A KIR3DL2

1.36e-061648320670355
Pubmed

Activating killer cell immunoglobulin-like receptor genes' association with recurrent miscarriage.

KIR3DL3 KIR2DL5A KIR3DL2

1.36e-061648319527230
Pubmed

Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA.

KIR3DL3 KIR2DL5A KIR3DL2

1.36e-061648320331834
Pubmed

Polymorphisms of KIR gene and HLA-C alleles: possible association with susceptibility to HLA-B27-positive patients with ankylosing spondylitis.

KIR3DL3 KIR2DL5A KIR3DL2

1.36e-061648320652381
Pubmed

Asian population frequencies and haplotype distribution of killer cell immunoglobulin-like receptor (KIR) genes among Chinese, Malay, and Indian in Singapore.

KIR3DL3 KIR2DL5A KIR3DL2

1.36e-061648318668235
Pubmed

HLA-DQA1*0505 sharing and killer immunoglobulin-like receptors in sub fertile couples: report from the 15th International Histocompatibility Workshop.

KIR3DL3 KIR2DL5A KIR3DL2

1.36e-061648320210919
Pubmed

Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation.

KIR3DL3 KIR2DL5A KIR3DL2

1.65e-061748319032228
Pubmed

The beneficial impact of missing KIR ligands and absence of donor KIR2DS3 gene on outcome following unrelated hematopoietic SCT for myeloid leukemia in the Chinese population.

KIR3DL3 KIR2DL5A KIR3DL2

1.65e-061748320173784
Pubmed

The role of killer immunoglobulin-like receptor haplotypes on the outcome of unrelated donor haematopoietic SCT for thalassaemia.

KIR3DL3 KIR2DL5A KIR3DL2

1.65e-061748320173792
Pubmed

Role of killer cell immunoglobulin-like receptor gene content and human leukocyte antigen-C group in susceptibility to human T-lymphotropic virus 1-associated myelopathy/tropical spastic paraparesis in Peru.

KIR3DL3 KIR2DL5A KIR3DL2

1.65e-061748320483367
Pubmed

[Effects of killer immunoglobulin-like receptor and human leukocyte antigen class I ligand on the prognosis of related donor hematopoietic stem cell transplantation].

KIR3DL3 KIR2DL5A KIR3DL2

1.65e-061748319968064
Pubmed

Association of KIR2DL5B gene with celiac disease supports the susceptibility locus on 19q13.4.

KIR2DL5A KIR2DL5B

1.87e-06248217215859
Pubmed

Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B.

KIR2DL5A KIR2DL5B

1.87e-06248212185535
Pubmed

Gene structure and promoter variation of expressed and nonexpressed variants of the KIR2DL5 gene.

KIR2DL5A KIR2DL5B

1.87e-06248211086080
Pubmed

Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians.

KIR3DL3 KIR2DL5A KIR3DL2

1.98e-061848319046302
Pubmed

Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infection.

KIR3DL3 KIR2DL5A KIR3DL2

1.98e-061848319846535
Pubmed

Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis.

KIR3DL3 KIR2DL5A KIR3DL2

1.98e-061848319630074
Pubmed

Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa.

KIR3DL3 KIR2DL5A KIR3DL2

1.98e-061848320519398
Pubmed

Association of killer cell immunoglobulin-like receptors and human leukocyte antigen-C genotypes in South Brazilian with type 1 diabetes.

KIR3DL3 KIR2DL5A KIR3DL2

1.98e-061848320580654
Pubmed

Distribution of killer cell immunoglobulin-like receptor genes in the mestizo population from Venezuela.

KIR3DL3 KIR2DL5A KIR3DL2

1.98e-061848320210918
Pubmed

Association between killer-cell immunoglobulin-like receptor genotypes and leprosy in Brazil.

KIR3DL3 KIR2DL5A KIR3DL2

2.35e-061948318778326
Pubmed

KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease.

KIR3DL3 KIR2DL5A KIR3DL2

2.35e-061948318571006
Pubmed

Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with solid tumors.

KIR3DL3 KIR2DL5A KIR3DL2

2.35e-061948320600442
Pubmed

Killer cell immunoglobulin-like receptor gene diversity in a Southern Brazilian population from the state of Paraná.

KIR3DL3 KIR2DL5A KIR3DL2

2.35e-061948318848853
Pubmed

Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis.

KIR3DL3 KIR2DL5A KIR3DL2

3.22e-062148319861144
Pubmed

The characteristics of allelic polymorphism in killer-immunoglobulin-like receptor framework genes in African Americans.

KIR3DL3 KIR3DL2

5.59e-06348221607693
Pubmed

Promoter variants of KIR2DL5 add to diversity and may impact gene expression.

KIR2DL5A KIR2DL5B

5.59e-06348218461314
Pubmed

Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7.

LILRA2 LILRA4

5.59e-06348212529506
Pubmed

Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform.

KIR3DL3 KIR2DL5A KIR3DL2

6.27e-062648336178190
Pubmed

Immunogenetic characteristics of patients with autoimmune gastritis.

KIR3DL3 KIR2DL5A KIR3DL2

8.79e-062948320082482
Pubmed

Killer-cell immunoglobulin-like receptors (KIR) in severe A (H1N1) 2009 influenza infections.

KIR2DL5A KIR2DL5B

1.12e-05448222652695
Pubmed

KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of Ig-like domains.

KIR2DL5A KIR2DL5B

1.12e-05448210820258
Pubmed

Plasticity in the organization and sequences of human KIR/ILT gene families.

LILRA2 LILRB4

1.12e-05448210781084
Pubmed

Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex.

LILRA4 LILRB4

1.12e-05448211491530
Pubmed

Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor complex.

KIR3DL3 LILRB4

1.12e-0544829862332
Pubmed

New assay to detect low-affinity interactions and characterization of leukocyte receptors for collagen including leukocyte-associated Ig-like receptor-1 (LAIR-1).

LAIR2 LILRB4

1.12e-05448219283782
Pubmed

Investigation of killer cell immunoglobulin-like receptor (KIR) gene diversity: KIR2DL2, KIR2DL5 and KIR2DS5.

KIR2DL5A KIR2DL5B

1.12e-05448218498296
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

HK3 CUBN SGMS1 PTCH1 ANK3 PLA2G15 ATG13 KIAA0753 CCSER2

1.51e-05108448911544199
Pubmed

The parathyroid hormone/parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation.

PTCH1 PTH1R

1.86e-0554829789035
Pubmed

Autophagic Flux Is Regulated by Interaction Between the C-terminal Domain of PATCHED1 and ATG101.

PTCH1 ATG13

1.86e-05548229453315
Pubmed

Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.

CEP152 ANK3 KIAA0753 ALG13 CCSER2

2.50e-0525148529778605
Pubmed

Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways.

LILRA2 LILRB4

2.79e-0564829079806
Pubmed

Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes.

LILRA2 LILRB4

3.90e-05748219658091
Pubmed

Expression of a killer cell receptor-like gene in plastic regions of the central nervous system.

KIR3DL3 KIR3DL2

3.90e-05748215748957
Pubmed

Targeted expression of SHH affects chondrocyte differentiation, growth plate organization, and Sox9 expression.

PTCH1 PTH1R

3.90e-05748215355563
Pubmed

Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells.

LILRA2 LILRB4

3.90e-05748217998301
Pubmed

PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps.

PTCH1 PTH1R

3.90e-05748212050144
Pubmed

Conditional deletion of Indian hedgehog from collagen type 2alpha1-expressing cells results in abnormal endochondral bone formation.

PTCH1 PTH1R

3.90e-05748216278811
Pubmed

Identification of the mouse killer immunoglobulin-like receptor-like (Kirl) gene family mapping to chromosome X.

KIR3DL3 KIR3DL2

3.90e-05748212618911
Pubmed

The diversity of KIR gene in Chinese Northern Han population and the impact of donor KIR and patient HLA genotypes on outcome following HLA-identical sibling allogeneic hematopoietic stem cell transplantation for hematological malignancy in Chinese people.

KIR3DL3 KIR3DL2

3.90e-05748218347914
Pubmed

A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.

LILRA2 LILRB4

5.19e-0584829548455
Pubmed

A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia.

KIR3DL3 KIR3DL2

5.19e-05848215730517
Pubmed

The CREB family of activators is required for endochondral bone development.

PTCH1 PTH1R

5.19e-05848211171337
Pubmed

Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes.

PTCH1 PTH1R

5.19e-05848220951345
Pubmed

Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development.

PTCH1 PTH1R

5.19e-05848211160153
Pubmed

Partial rescue of PTH/PTHrP receptor knockout mice by targeted expression of the Jansen transgene.

PTCH1 PTH1R

6.67e-05948211713230
Pubmed

Collagen XXVII organises the pericellular matrix in the growth plate.

PTCH1 PTH1R

6.67e-05948222206015
Pubmed

delta-EF1 is a negative regulator of Ihh in the developing growth plate.

PTCH1 PTH1R

6.67e-05948219948490
Pubmed

Distribution of KIR genes in the Czech population.

KIR3DL3 KIR3DL2

6.67e-05948218186800
Pubmed

Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3.

PTCH1 PTH1R

6.67e-0594829811582
Pubmed

Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh.

PTCH1 PTH1R

6.67e-05948222190639
Pubmed

In situ gene expression analysis during BMP2-induced ectopic bone formation in mice shows simultaneous endochondral and intramembranous ossification.

PTCH1 PTH1R

6.67e-05948212708796
Pubmed

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation.

PTCH1 PTH1R

8.33e-051048216284117
Pubmed

Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.

LILRA2 LILRB4

8.33e-051048218802077
Pubmed

Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus.

KIR3DL3 KIR2DL5B

8.33e-051048221206914
Pubmed

Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.

MUC5B KANSL1

1.02e-041148224429156
Pubmed

The fused toes locus is essential for somatic-germ cell interactions that foster germ cell maturation in developing gonads in mice.

SPAG9 IRX6

1.02e-041148221293032
Pubmed

Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival.

PTCH1 PTH1R

1.02e-041148214722611
Pubmed

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.

PTCH1 PTH1R

1.02e-041148210465785
Pubmed

A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos.

PTCH1 PTH1R

1.02e-041148210861287
InteractionRAVER2 interactions

SPATA20 BAG2 ALG13

9.18e-0619443int:RAVER2
Cytoband19q13.4

LAIR2 LILRA2 KIR3DL2 LILRA4 LILRB4

2.14e-087948519q13.4
CytobandEnsembl 112 genes in cytogenetic band chr19q13

LAIR2 KIR3DL3 KLK12 LILRA2 KIR3DX1 KIR3DL2 LILRA4 LILRB4

3.03e-051192488chr19q13
Cytoband17q21.33

SPATA20 SPAG9

8.55e-044148217q21.33
Cytoband19p13.3

KIR2DL5A PRSS57 KIR2DL5B

1.98e-0323748319p13.3
GeneFamilyCD molecules|Killer cell immunoglobulin like receptors

KIR3DL3 KIR2DL5A KIR3DX1 KIR2DL5B KIR3DL2

4.24e-1118275620
GeneFamilyADAM metallopeptidase domain containing|CD molecules

LAIR2 KIR3DL3 KIR2DL5A LILRA2 KIR3DL2 LILRA4 LILRB4

1.35e-06394277471
GeneFamilyCD molecules|Activating leukocyte immunoglobulin like receptors

LILRA2 LILRA4

3.21e-0562721181
GeneFamilyPhospholipases

PLB1 PLA2G15

1.78e-0342272467
GeneFamilySterile alpha motif domain containing

ARAP3 SGMS1

7.60e-0388272760
CoexpressionMARTENS_TRETINOIN_RESPONSE_UP

PPP1R26 KLK12 SPATA20 MUC5B CAMK1G IRX6 HK3 PTH1R LILRB4

1.49e-05855469M2098
ToppCellBL-critical-LOC-Lymphoid-NK|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

LAIR2 KIR3DX1 PRSS57 KIR3DL2 CCSER2

1.77e-06196465cfbeaabbeeb197f0cf8240a752d1f2995d59d7b7
ToppCellInfluenza-Influenza_Severe-Lymphocyte-T/NK-NK|Influenza_Severe / Disease, condition lineage and cell class

LAIR2 KIR3DX1 PRSS57 KIR3DL2 CCSER2

1.95e-0620046504ac14414d550b14dc46d682e7af9dd43982211a
ToppCellBiopsy_Control_(H.)-Immune-NK_cells|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

LAIR2 KIR3DL3 KIR3DX1 PRSS57 KIR3DL2

1.95e-06200465c93393d52ed1c238d539f254fd2a95eb101a6f65
ToppCellfacs-Spleen-nan-24m-Myeloid|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRSS57 ARAP3 HK3 LILRB4

2.03e-05156464034d4359359a44c205c6931f38a375271ac2752b
ToppCellfacs-Spleen-nan-24m-Myeloid-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRSS57 ARAP3 HK3 LILRB4

2.03e-051564642a4dac4100c0339aad4905b8eaca6e8fe806718b
ToppCellfacs-Spleen-nan-24m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRSS57 ARAP3 HK3 LILRB4

2.03e-0515646421267718d3a3dc19988663b6846aed8bb3eae836
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MUC5B PLB1 WDR17 CECR2

2.24e-05160464c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MUC5B PLB1 WDR17 CECR2

2.24e-0516046425c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

LAIR2 KIR3DX1 KIR3DL2 SGCD

2.29e-05161464bf4bfb416cb6ef43fc8cf0ffc2d7f0b6b42ab4da
ToppCelldroplet-Spleen-nan-21m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRSS57 ARAP3 HK3 LILRB4

2.65e-05167464cfcd72292c733cdb18c92fdb61b68f6806d22c8c
ToppCellNS-critical-LOC-Lymphoid-NK|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

LAIR2 KIR3DX1 KIR3DL2 CCSER2

2.90e-05171464adda76991d9b150bb8ccf3989b7cbbf41843cf0b
ToppCell343B-Myeloid-Dendritic-pDC|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

CECR2 CALCOCO1 LILRA4 LILRB4

3.18e-05175464b30589ff9dc18e745afe61f289e6d576c9c6c6b2
ToppCellmetastatic_Brain-B_lymphocytes-GrB-secreting_B_cells|B_lymphocytes / Location, Cell class and cell subclass

OVOS2 IQCN LILRA4 LILRB4

3.32e-0517746443e1d0d3cf8f0c02e67d91f8dd1761df23d59e07
ToppCell10x3'2.3-week_17-19-Lymphocytic_NK|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

LAIR2 KIR3DL3 KIR3DL2 CCSER2

3.55e-051804641c8398342d3fa4d5ca9a8a63626cc497c5291446
ToppCell10x3'2.3-week_17-19-Lymphocytic_NK-T_NK-CD56_bright_NK|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

LAIR2 KIR3DL3 KIR3DL2 CCSER2

3.55e-05180464ddbab26b05f057bd78b78773381cd447bd2e2726
ToppCell10x3'2.3-week_17-19-Lymphocytic_NK-T_NK|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

LAIR2 KIR3DL3 KIR3DL2 CCSER2

3.55e-051804640a98d21fec67a890e75ebf0e2d23adddd77da214
ToppCellwk_08-11-Hematologic-Myeloid-Non-cla._mono.|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

PLB1 LILRA2 HK3 LILRB4

3.86e-05184464324f91b70913bda3509e234aaf23b46fad91e076
ToppCelldroplet-Kidney-nan-18m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SARDH CUBN ANK3 PTH1R

3.86e-05184464e02859bbac36dbbd55d7ae8cb5e46b764d7c6381
ToppCelldroplet-Heart-nan-18m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARAP3 SGMS1 PRAG1 PTH1R

4.03e-0518646449ad01d216860a2bd4d63905a7064471b02f2b37
ToppCelldroplet-Kidney-nan-18m-Epithelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SARDH CUBN ANK3 PTH1R

4.11e-05187464236e9857729670e87eed30fad58f49e1f56e4a85
ToppCell5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Myeloid-MPO+_mono-neutrophil|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LILRA2 PRSS57 HK3 LILRB4

4.11e-0518746449c7ac6fa53ecc7395c2b02decd12dfe013e44e6
ToppCelldroplet-Heart-nan-18m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARAP3 SGMS1 PRAG1 PTH1R

4.20e-051884649dfa2e0b73640459cdf88277291e3ab9c33e0217
ToppCellwk_08-11-Hematologic-Myeloid-Promonocyte-like|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

LILRA2 PRSS57 HK3 LILRB4

4.20e-051884642ae945d96a011f246d04a42bcd6ef443232b03f4
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Neuron|GW09 / Sample Type, Dataset, Time_group, and Cell type.

ANK3 ASIC1 CECR2 CALCOCO1

4.29e-051894643717d1148e26ac78a26aea0ca1dbfbb9d3668877
ToppCell(1)_T_cells-(1)_T_CD8_gd|(1)_T_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)

KIR3DL3 KIR3DX1 PRSS57 KIR3DL2

4.38e-05190464268772d2adff34f7175b8474e95b67fd96dc1234
ToppCellmetastatic_Brain-T/NK_cells-NK|metastatic_Brain / Location, Cell class and cell subclass

LAIR2 KIR3DX1 PRSS57 KIR3DL2

4.38e-0519046450e937ba0600e1ac6215f056bb545dc1e8b28a76
ToppCell3'-GW_trimst-1-LargeIntestine-Hematopoietic-Myeloid-MPO+_mono-neutrophil|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LILRA2 PRSS57 HK3 LILRB4

4.38e-05190464bee9c9d0fc9cfba0a67dacc4569307cb326d489b
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-C|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SPATA20 LILRA2 LILRA4 LILRB4

4.38e-05190464259085b9731902ca0956233afafe1db6fc98e851
ToppCell10x5'v1-week_14-16-Lymphocytic_NK-T_NK-mature_NK|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

LAIR2 KIR3DL3 KIR3DL2 CCSER2

4.56e-05192464e48bbcb97c113f323ad4db96bd10d593b9206923
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-C|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LILRA2 PLA2G15 LILRA4 LILRB4

4.56e-051924644037b4c4fbb40541b8c424c36d3871a57891b8dd
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PLA2G15 CECR2 LILRA4 LILRB4

4.56e-0519246469758a256386a6ed3a6e2c94c55d59baa34892d7
ToppCellTracheal-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LAIR2 KIR3DL3 KIR3DX1 KIR3DL2

4.65e-0519346491a1c9b8390cbd881db8c49d8f34feca0d1067d6
ToppCellBac-SEP-Lymphocyte-T_NK-NK|Bac-SEP / Disease, Lineage and Cell Type

LAIR2 KIR3DL3 KIR3DX1 PRSS57

4.65e-051934648aa4ed2b11c6189d86e7de6bc68782fd156a37fb
ToppCellwk_20-22-Hematologic-Myeloid-DC3|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

PLB1 LILRA2 HK3 LILRB4

4.65e-0519346412d1e7ed0bcd1259d6dc8ae962aad69586e5d26b
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LILRA2 PLA2G15 LILRA4 LILRB4

4.65e-05193464697518bab1338dc441b2d93b410d957e692f20e6
ToppCellfacs-Marrow-B-cells-18m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL24 CAMK1G CECR2 CALCOCO1

4.75e-05194464ad1aacff97beb76f4211942676e1d5e84087d44e
ToppCellfacs-Marrow-B-cells-18m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL24 CAMK1G CECR2 CALCOCO1

4.75e-05194464fdd59b1e036b2d6d8877e1a920a0e56a91a2a882
ToppCell367C-Lymphocytic-NK_cells|367C / Donor, Lineage, Cell class and subclass (all cells)

KIR3DL3 KIR3DX1 PRSS57 KIR3DL2

4.75e-051944642e447de50b3f4b59e3b9928df83879955fed93cc
ToppCell3'-Distal_airway-Immune_Myeloid|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HK3 PLA2G15 LILRA4 LILRB4

4.84e-051954644df004b8ca7669a57d85c6dffef5b82b4ea1dfdf
ToppCellIIF-Lymphocyte-T_NK-NK|IIF / Disease, Lineage and Cell Type

LAIR2 KIR3DL3 PRSS57 KIR3DL2

4.84e-05195464464ce05cb52f78aee22d3baa6641b37bd53aae16
ToppCell390C-Myeloid-Monocyte|390C / Donor, Lineage, Cell class and subclass (all cells)

LILRA2 HK3 LILRA4 LILRB4

4.84e-051954646f09bfd6394c10c90c23d130a18941bf490e1a8f
ToppCellMonocytes-NUPR1+_Monocytes|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

LILRA2 HK3 PLA2G15 LILRB4

4.84e-051954645e12201ce7ba912e7faa123ca200e609252ba288
ToppCellwk_15-18-Hematologic-Myeloid-DC3|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PLB1 LILRA2 HK3 LILRB4

4.94e-0519646420808c2ce010e4fcda092ecce94487f0afff733b
ToppCelltumor_Lung-T/NK_cells-NK|tumor_Lung / Location, Cell class and cell subclass

LAIR2 KIR3DX1 PRSS57 KIR3DL2

4.94e-05196464006e630f3d8033f45c6b7e9154d77000c7b0cb70
ToppCellmetastatic_Lymph_Node-T/NK_cells-NK|metastatic_Lymph_Node / Location, Cell class and cell subclass

LAIR2 KIR3DX1 PRSS57 KIR3DL2

4.94e-05196464f69f53e2ac1818b4ad0161b0bd70655e98ef65f0
ToppCellCOVID-19_Severe-NK|World / disease group, cell group and cell class

LAIR2 KIR3DL3 KIR3DX1 KIR3DL2

4.94e-05196464f46ca7cc2d8407d0dcaa77c4b16a2c1f2a23734d
ToppCellInfluenza_Severe-NK|Influenza_Severe / Disease group and Cell class

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.04e-05197464d0f58ee4c02573d214deb210bb7efd3d6118f267
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_NK-NK_dim-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.04e-0519746476304df40f87224f8e415677e3ee8fb183fe0c03
ToppCellHealthy_donor-NK|World / disease group, cell group and cell class (v2)

LAIR2 KIR3DX1 KIR3DL2 SGCD

5.14e-051984644c9c40e91173836ad0df2eba635a4cb3385e80c6
ToppCellCOVID-19_Severe-NK|COVID-19_Severe / Disease condition and Cell class

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.14e-05198464742c4d6016cfa48444a5919a885ab8d02cad7e18
ToppCellURO-Lymphocyte-T_NK-NK|URO / Disease, Lineage and Cell Type

LAIR2 KIR3DL3 PRSS57 KIR3DL2

5.14e-051984642ccff882aafabf041df15b31d9abc50dcbc2696e
ToppCellmild_COVID-19_(asymptomatic)-NK|World / disease group, cell group and cell class (v2)

LAIR2 KIR3DX1 PRSS57 CCSER2

5.14e-051984647a0aac52d785037455e068e1b25de4b2bf0fff79
ToppCell390C-Lymphocytic-NK_cells|390C / Donor, Lineage, Cell class and subclass (all cells)

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.14e-05198464872ddb2738c5e0375830bb0e5b2c50383bf58738
ToppCellmild_COVID-19_(asymptomatic)-NK|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.14e-051984641e43181c13e054570046c7a973ddc1c586e259b0
ToppCellsevere_influenza-NK|severe_influenza / disease group, cell group and cell class (v2)

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.14e-05198464d431beb870ff5e165d98febfb27049d729e37dc8
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-NK|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.14e-05198464e39ef71f3a9e0591bc0300ae132036fe2f8d5716
ToppCell390C-Lymphocytic-NK_cells|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.14e-05198464623e5ada1a54cd42c32a1519b84dbe782384ee0c
ToppCellproximal-Hematologic-Natural_Killer|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.24e-05199464b7463dffca8b2a7f053bfecdabcb8429989cbc0f
ToppCellproximal-3-Hematologic-Natural_Killer|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.24e-05199464bbaf31cf35d1706c421bef54fe2f809fa6590a72
ToppCellBronchial-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.24e-05199464ed460ff7fb82d3f0eed689d56f50d40514f74b48
ToppCellnormal_Lung-T/NK_cells-NK|T/NK_cells / Location, Cell class and cell subclass

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.24e-05199464407ae8575bb4dec7fe10d48ceb8f32a03f5ac1bb
ToppCellmild_COVID-19-NK|mild_COVID-19 / disease group, cell group and cell class (v2)

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.24e-051994644854f25ee436e1cf577744373ffd87b1221d2b88
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-NK|T/NK_cells / Location, Cell class and cell subclass

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.24e-051994644e7be837fd23934a338864380fa24b00db007358
ToppCellproximal-Hematologic-Natural_Killer-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.24e-05199464e523ae54f34612c94cf7677309c11d351747bdf4
ToppCellBronchial-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.34e-05200464b4d956067eb292cf2855c674d1eb05a5f2d988f7
ToppCellBronchial-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.34e-05200464d1cfc4ef6ae75c486427e393d98b84a2a7ec67fe
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.34e-052004640a6fc7eff94e2f71af9f31a01779aafd2f4a6699
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.34e-05200464eda7a1d822e8663510662bc0ca34eaccc88d71ca
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.34e-052004640b65855617fb7730de48facf411e2a8980f9f780
ToppCellParenchymal-10x3prime_v2-Immune_Lymphocytic-NK-ILC-T_NK-NK|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.34e-0520046485bb2f4c97b03258615bc09279c70766c99ec942
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Monocytic-Monocyte_CD14|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

LILRA2 HK3 LILRA4 LILRB4

5.34e-052004647eb2662b0eafc3bf1096b5a34a21f65e3b7bf1a2
ToppCellBronchial-10x5prime-Immune_Lymphocytic-NK-ILC|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.34e-05200464c09bb5c994f098d86e873bd3f1d911b02563e6e2
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LILRA2 HK3 LILRA4 LILRB4

5.34e-0520046480e0483d5ab0c6213aae0ec62619f57e6ec0e4c2
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-NK-ILC|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.34e-052004644150170a135c37a7932bfb61acedac22dad01a3e
ToppCellBiopsy_Other_PF-Immune-NK_cells|Biopsy_Other_PF / Sample group, Lineage and Cell type

LAIR2 KIR3DX1 PRSS57 KIR3DL2

5.34e-05200464418d665b8431697fc9e516258c9fe374257750d9
ToppCellLV-03._Atrial_Cardiomyocyte|LV / Chamber and Cluster_Paper

IRX6 ANK3 SGCD

2.58e-041204633b77bd0e3630cdd45001cecf5e47660a90ebc92e
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

LAIR2 KLK12 HK3

3.57e-041344633b67c02b430b6d58467f36e606c478d3eea0063f
ToppCellClub_cells-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

KLK12 MUC5B KIR3DX1

3.89e-04138463133015953fc660d00339f47b415da5e9872313a2
ToppCellLPS-IL1RA+antiTNF-Myeloid-Dendritic_cells-Monocytes-Macrophages|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLB1 HK3 PLA2G15

4.59e-04146463b76110b159acd27a2c8d6a9f98336608ace1ec12
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1|368C / Donor, Lineage, Cell class and subclass (all cells)

LAIR2 KIR3DX1 KIR3DL2

4.68e-04147463743767abdb3b5ecad870b617f515b037ce280818
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Thalamus / BrainAtlas - Mouse McCarroll V32

SPATA20 CAMK1G SGCD

4.77e-04148463afebb64365c94b9476494bffe7c364677f19c8cf
ToppCellThalamus-Neuronal-Inhibitory|Thalamus / BrainAtlas - Mouse McCarroll V32

SPATA20 CAMK1G SGCD

4.77e-041484635f82e5ecacfd223020b8ee975c17d68c1fe6db38
ToppCellMild_COVID-19-Myeloid-TRAM2|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

LILRA2 WDR17 CECR2

5.36e-04154463ab648f6b29eb9e499e46cbdbaf3c5cf6b94d1f64
ToppCellfacs-Spleen-nan-3m-Myeloid|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARAP3 HK3 LILRB4

5.56e-04156463f532ef4e92ac7661b1a8a4f2e98d80ce8d4e3655
ToppCell367C-Lymphocytic-NK_cells-NK_cell_C|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

KIR3DL3 PRSS57 KIR3DL2

5.56e-04156463e6798d2b9c2c1fc6525c24f596f25aa85a375651
ToppCell367C-Lymphocytic-NK_cells-NK_cell_C|367C / Donor, Lineage, Cell class and subclass (all cells)

KIR3DL3 PRSS57 KIR3DL2

5.56e-04156463a1b9e7621b646d354c2ccd850ce6a4fa9ff8a026
ToppCellfacs-Spleen-nan-3m-Myeloid-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARAP3 HK3 LILRB4

5.56e-04156463da4f35353a84d919e683554932f110e29568df33
ToppCellfacs-Spleen-nan-3m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARAP3 HK3 LILRB4

5.56e-04156463f1e25ff85c5f2f8555f9fb5ae5daed7ddb418fd1
ToppCellfacs-Trachea-18m-Hematologic-myeloid-granulocyte-granulocyte_l8|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HK3 CECR2 LILRB4

5.67e-041574635098675f64342c41c5ca3551b24962d10c83e64d
ToppCellfacs-Marrow-B-cells-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARAP3 HK3 LILRB4

5.67e-041574630673c7161c25feceee8f1e5fd237171576c42c6b
ToppCellfacs-Marrow-B-cells-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARAP3 HK3 LILRB4

5.67e-04157463d307d0b48af35e0e1af41ecd3ebf91be8fd29dc0
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-pDCs|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

OVOS2 LILRA4 LILRB4

5.77e-041584632af7beb48272e5368d9ba6b80f08d47ab8556c08
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CUBN PTCH1 PRAG1

5.77e-041584636811dc4f101dfa9a9cc13d949760d43aa522bf3b
ToppCellSevere-Lymphoid-NK-|Severe / Condition, Lineage, Cell class and cell subclass

KIR3DX1 CUBN KIR3DL2

5.99e-04160463d276c6cb8317d5fb19e7b4fe5238abaf0272d4c6
ToppCellControl-B_intermediate-10|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ANK3 PRAG1 LILRA4

6.21e-04162463aa80452b972bb8ad3670ffaba4ce26fadb33b185
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRSS57 LILRA4 LILRB4

6.32e-041634633087224d3f16f5d3aecc3e1e4366220231afe31f
ToppCellILEUM-non-inflamed-(3)_pDC|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PRSS57 LILRA4 LILRB4

6.32e-04163463bc5411702badab39143905aa51676b4bbfad2041
ToppCell390C-Lymphocytic-NK_cells-NK_cell_B2|390C / Donor, Lineage, Cell class and subclass (all cells)

LAIR2 KIR3DL3 KIR3DL2

6.32e-04163463036e65de0f8fc391f3e4d299bf4c05ee5c3b5a37
ToppCellInt-URO-Myeloid-tDC|Int-URO / Disease, Lineage and Cell Type

OVOS2 LILRA4 LILRB4

6.55e-041654639803c3db6cdcf925bea7d9c382bf4fd05acf3509
ToppCellC_02|World / shred on cell type and cluster

OVOS2 PLB1 CUBN

6.55e-04165463a456c2c9ffe8dc91e17cac84ba87b88e016f8e6d
ComputationalNeighborhood of IL2RB

LAIR2 KIR3DL3 KIR3DL2

2.75e-0446303GNF2_IL2RB
DrugIL-T

LAIR2 LILRA2 KIR3DX1 KIR3DL2 LILRA4 LILRB4

1.90e-0956486CID000150551
DrugWY-14643; Down 200; 100uM; SKMEL5; HG-U133A

PPP1R26 KLK12 SPATA20 ASIC1 ATG13 CCSER2

3.74e-06199486495_DN
DrugAC1L1FCN

LILRA2 KIR3DX1 KIR3DL2

3.93e-0615483CID000003178
DrugC2(+)

KIR3DX1 KIR3DL2

1.30e-053482CID006857645
Drugwortmannin from Penicillium funiculosum; Up 200; 0.01uM; MCF7; HT_HG-U133A

KLHL24 MUC5B PTCH1 ANK3 CALCOCO1

4.11e-051834851668_UP
Drugwortmannin; Up 200; 0.01uM; MCF7; HT_HG-U133A_EA

KLHL24 PTCH1 ANK3 ATG13 CALCOCO1

4.79e-05189485911_UP
DrugBucladesine sodium salt [16980-89-5]; Down 200; 7.8uM; HL60; HT_HG-U133A

LILRA2 SGMS1 PTCH1 ALG13 CCSER2

5.42e-051944852741_DN
DrugEthamivan [304-84-7]; Down 200; 18uM; PC3; HT_HG-U133A

KLHL24 CEP152 ATG13 KIAA0753 CCSER2

5.42e-051944857260_DN
Drugcholine

PLB1 SPAG9 CEPT1 SARDH SGMS1 PTCH1

5.49e-05320486CID000000305
DrugPargyline hydrochloride [306-07-0]; Up 200; 20.4uM; HL60; HG-U133A

LAIR2 CEP152 CAMK1G ATG13 LILRB4

5.70e-051964851418_UP
DrugMethazolamide [554-57-4]; Down 200; 17uM; HL60; HT_HG-U133A

LILRA2 SGMS1 KIAA0753 ALG13 CCSER2

5.70e-051964852733_DN
Diseaseleukocyte immunoglobulin-like receptor subfamily B member 1 measurement

LILRA2 KIR3DX1 LILRB4

1.39e-0615443EFO_0008208
Diseasegranulocyte colony-stimulating factor measurement

LILRA2 KIR3DX1

1.18e-0334442EFO_0008142
DiseaseCOVID-19 symptoms measurement

MUC5B KANSL1

1.25e-0335442EFO_0600019
Diseasetumor necrosis factor-alpha measurement

LILRA2 KIR3DX1

2.44e-0349442EFO_0004684
Diseaseinterleukin 1 receptor antagonist measurement

LILRA2 KIR3DX1

2.85e-0353442EFO_0004754
Diseasebirth weight, parental genotype effect measurement

ARAP3 PTCH1 PTH1R

2.95e-03192443EFO_0004344, EFO_0005939

Protein segments in the cluster

PeptideGeneStartEntry
PSSSPMHPCNYRTAG

ATG13

221

O75143
TPGPSESGCMHITFR

CEP152

1511

O94986
HGGPSTMVPATSGYC

ALG13

751

Q9NP73
PTTGTVHIMDPGCLY

ARAP3

191

Q8WWN8
SSGYMRPPCKSAGHR

CECR2

856

Q9BXF3
YGHCPSTPATSSTAM

MUC5B

2411

Q9HC84
TMPPGVQLHCLYGTG

PLA2G15

321

Q8NCC3
MYPGPTVTKTAPHTC

IQCN

381

Q9H0B3
SAETGSPRLTMHYPC

IRX6

331

P78412
IMGPVTPAHAGTYRC

KIR3DL2

81

P43630
LMGPVTPAHAGTYRC

KIR2DL5A

81

Q8N109
VTPGTFIPYCSMAHA

SPAG9

1201

O60271
RMGPVTSAHVGTYRC

LILRA2

381

Q8N149
PMSPVTSAHAGTYRC

LILRA4

381

P59901
HYFITVMASGPSPCP

EYS

146

Q5T1H1
TCHGVYPGRITSNMV

KLK12

171

Q9UKR0
PMSPVTSVHGGTYRC

LILRB4

181

Q8NHJ6
LMGPVTPAHAGTYRC

KIR2DL5B

81

Q8NHK3
LMGPVTPAHAGTYRC

KIR3DL3

81

Q8N743
HYVLLDPSCSGSGMP

NSUN5P2

116

Q63ZY6
CGSGSINTMPPEIHY

KANSL1

636

Q7Z3B3
YGPMHSVPSRIACRG

OVOS2

691

Q6IE36
AVRMLPTYVGSTPHG

HK3

71

P52790
SMGPVTPAHAGAYRC

KIR3DX1

181

Q9H7L2
MSTACGTPGYVAPEV

CAMK1G

176

Q96NX5
MSLYSACSSEVPHGP

BAG2

136

O95816
GPGVTSTLGYRMVHP

CCSER2

306

Q9H7U1
YCGTDMPHPITSFSS

CUBN

1696

O60494
PESPVGFGHMSTTGC

CEPT1

16

Q9Y6K0
AAMPRPVSYHGCVTI

KLHL24

576

Q6TFL4
ITTTTRMVYHSPPGG

ANK3

2246

Q12955
ECHYTLPPGTMPSAS

CALCOCO1

31

Q9P1Z2
PGSHVTFMCRGPVGV

LAIR2

41

Q6ISS4
SGYCPSSTHVMPEEP

SSPOP

5081

A2VEC9
GGHEVTPHSRPYMAS

PRSS57

36

Q6UWY2
AMGSSVPGYCQPITT

PTCH1

1356

Q13635
TFHMGCGSPSFLTPS

PPP1R26

996

Q5T8A7
YGLTCHPSRPFTMAS

WDR17

656

Q8IZU2
VPPGMQHSIGDYCSR

KIAA0753

891

Q2KHM9
YFSPSVPMPVCHTGK

PLB1

116

Q6P1J6
PPGSTVYTCMLNHRG

SARDH

601

Q9UL12
PCESLRGHPAGMTYA

ASIC1

496

P78348
YGPMVSHTSVTNVGP

PTH1R

496

Q03431
YTHHRSTMPGSVGPQ

SGCD

6

Q92629
LMRTCYTGPGGTVEH

SPATA20

551

Q8TB22
YVTTLPVPGMHFNCS

SGMS1

231

Q86VZ5
GNSRCPPAYTMVGLH

PRAG1

151

Q86YV5
SFSNMVPCSHPYIGT

SLC30A9

46

Q6PML9