Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	adenylate cyclase activity	NPR2 ADCY7 ADCY9	2.72e-06	18	31	3	GO:0004016
GeneOntologyMolecularFunction	cyclase activity	NPR2 ADCY7 ADCY9	6.71e-06	24	31	3	GO:0009975
GeneOntologyMolecularFunction	phosphorus-oxygen lyase activity	NPR2 ADCY7 ADCY9	7.61e-06	25	31	3	GO:0016849
GeneOntologyMolecularFunction	xenobiotic transmembrane transporter activity	SLC22A6 ABCA8	1.27e-03	34	31	2	GO:0042910
GeneOntologyBiologicalProcess	cyclic nucleotide biosynthetic process	NPR2 ADCY7 ADCY9	5.33e-06	23	31	3	GO:0009190
GeneOntologyBiologicalProcess	cyclic purine nucleotide metabolic process	NPR2 ADCY7 ADCY9	3.90e-05	44	31	3	GO:0052652
GeneOntologyBiologicalProcess	cyclic nucleotide metabolic process	NPR2 ADCY7 ADCY9	4.18e-05	45	31	3	GO:0009187
GeneOntologyBiologicalProcess	cAMP biosynthetic process	ADCY7 ADCY9	1.19e-04	11	31	2	GO:0006171
GeneOntologyBiologicalProcess	organophosphate metabolic process	GMPS ENPP7 NPR2 SLC2A6 ABCA8 ADCY7 ADCY9 ALOX15	2.17e-04	1142	31	8	GO:0019637
Domain	A/G_cyclase_CS	NPR2 ADCY7 ADCY9	2.77e-06	17	31	3	IPR018297
Domain	Nucleotide_cyclase	NPR2 ADCY7 ADCY9	3.32e-06	18	31	3	IPR029787
Domain	-	NPR2 ADCY7 ADCY9	3.32e-06	18	31	3	3.30.70.1230
Domain	GUANYLATE_CYCLASE_2	NPR2 ADCY7 ADCY9	3.94e-06	19	31	3	PS50125
Domain	GUANYLATE_CYCLASE_1	NPR2 ADCY7 ADCY9	3.94e-06	19	31	3	PS00452
Domain	A/G_cyclase	NPR2 ADCY7 ADCY9	3.94e-06	19	31	3	IPR001054
Domain	CYCc	NPR2 ADCY7 ADCY9	3.94e-06	19	31	3	SM00044
Domain	Guanylate_cyc	NPR2 ADCY7 ADCY9	3.94e-06	19	31	3	PF00211
Domain	MFS	SLC22A6 MFSD1 SLC2A6	7.51e-04	108	31	3	PS50850
Domain	MFS_dom	SLC22A6 MFSD1 SLC2A6	1.40e-03	134	31	3	IPR020846
Domain	Sugar_tr	SLC22A6 SLC2A6	1.62e-03	36	31	2	PF00083
Domain	MFS_sugar_transport-like	SLC22A6 SLC2A6	1.62e-03	36	31	2	IPR005828
Pathway	REACTOME_CA_DEPENDENT_EVENTS	ADCY7 ADCY9 KPNA2	4.66e-05	37	27	3	M749
Pathway	REACTOME_DAG_AND_IP3_SIGNALING	ADCY7 ADCY9 KPNA2	6.36e-05	41	27	3	M512
Pathway	WP_ENVELOPE_PROTEINS_AND_THEIR_POTENTIAL_ROLES_IN_EDMD_PHYSIOPATHOLOGY	LEMD3 ADCY7 ADCY9	9.00e-05	46	27	3	M39828
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	ADCY7 ADCY9 KPNA2	1.46e-04	54	27	3	M26911
Pathway	REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY	ADCY7 ADCY9	1.57e-04	10	27	2	M19522
Pathway	REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY	ADCY7 ADCY9	1.57e-04	10	27	2	MM14668
Pathway	KEGG_PURINE_METABOLISM	GMPS NPR2 ADCY7 ADCY9	2.23e-04	159	27	4	M14314
Pathway	WP_PURINE_METABOLISM	GMPS NPR2 ADCY7 ADCY9	2.95e-04	171	27	4	MM15909
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	ADCY7 ADCY9	3.17e-04	14	27	2	MM14669
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	ADCY7 ADCY9	3.17e-04	14	27	2	M750
Pathway	KEGG_MEDICUS_REFERENCE_PTH_PTH1R_PKA_SIGNALING_PATHWAY	ADCY7 ADCY9	3.65e-04	15	27	2	M47504
Pathway	KEGG_MEDICUS_REFERENCE_EP_NE_ADRB_CAMP_SIGNALING_PATHWAY	ADCY7 ADCY9	3.65e-04	15	27	2	M47794
Pathway	PID_LPA4_PATHWAY	ADCY7 ADCY9	3.65e-04	15	27	2	M56
Pathway	KEGG_MEDICUS_REFERENCE_LHCGR_GNAS_PKA_SIGNALING_PATHWAY	ADCY7 ADCY9	4.17e-04	16	27	2	M47645
Pathway	KEGG_MEDICUS_REFERENCE_FSHR_GNAS_PKA_SIGNALING_PATHWAY	ADCY7 ADCY9	4.17e-04	16	27	2	M47650
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	ADCY7 ADCY9	4.17e-04	16	27	2	MM14492
Pathway	WP_MAJOR_RECEPTORS_TARGETED_BY_EPINEPHRINE_AND_NOREPINEPHRINE	ADCY7 ADCY9	4.17e-04	16	27	2	M39849
Pathway	KEGG_MEDICUS_REFERENCE_CX3CR1_GNAI_AC_PKA_SIGNALING_PATHWAY	ADCY7 ADCY9	4.72e-04	17	27	2	M47544
Pathway	REACTOME_PKA_ACTIVATION_IN_GLUCAGON_SIGNALLING	ADCY7 ADCY9	4.72e-04	17	27	2	M26995
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	ADCY7 ADCY9	6.57e-04	20	27	2	M759
Pathway	REACTOME_OPIOID_SIGNALLING	ADCY7 ADCY9 KPNA2	6.59e-04	90	27	3	M6467
Pathway	REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS	PRND MDGA1 TEX101	7.25e-04	93	27	3	M26985
Pathway	REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS	PRND MDGA1 TEX101	8.69e-04	99	27	3	MM14624
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY	ADCY7 ADCY9	9.50e-04	24	27	2	M47520
Pathway	REACTOME_CA_DEPENDENT_EVENTS	ADCY7 ADCY9	1.12e-03	26	27	2	MM14495
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAI_AC_PKA_SIGNALING_PATHWAY	ADCY7 ADCY9	1.12e-03	26	27	2	M47553
Pathway	KEGG_MEDICUS_REFERENCE_CRHR_PKA_ACTH_SIGNALING_PATHWAY	ADCY7 ADCY9	1.20e-03	27	27	2	M47518
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_RASD1_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY	ADCY7 ADCY9	1.20e-03	27	27	2	M47519
Pathway	KEGG_MEDICUS_REFERENCE_GHRHR_PKA_GH_SIGNALING_PATHWAY	ADCY7 ADCY9	1.29e-03	28	27	2	M47647
Pathway	KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION	NPR2 ADCY7 ADCY9	1.34e-03	115	27	3	M9387
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_ACTH_CORTISOL_SIGNALING_PATHWAY	ADCY7 ADCY9	1.39e-03	29	27	2	M47515
Pathway	KEGG_MEDICUS_REFERENCE_TSH_TG_SIGNALING_PATHWAY	ADCY7 ADCY9	1.39e-03	29	27	2	M47627
Pathway	KEGG_MEDICUS_VARIANT_CYP11B1_CYP11B2_FUSION_TO_ACTH_CORTISOL_SIGNALING_PATHWAY	ADCY7 ADCY9	1.59e-03	31	27	2	M47507
Pathway	KEGG_MEDICUS_REFERENCE_ACTH_CORTISOL_SIGNALING_PATHWAY	ADCY7 ADCY9	1.69e-03	32	27	2	M47506
Pathway	REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS	ADCY7 ADCY9	1.80e-03	33	27	2	MM15058
Pathway	REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION	ADCY7 ADCY9	1.80e-03	33	27	2	M11575
Pathway	KEGG_MEDICUS_REFERENCE_ADRB3_UCP1_SIGNALING_PATHWAY	ADCY7 ADCY9	2.02e-03	35	27	2	M47969
Pathway	REACTOME_SIGNALING_BY_HEDGEHOG	SYVN1 ADCY7 ADCY9	2.21e-03	137	27	3	MM15182
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC22A6 SLC36A1 SLC2A6 ABCA8 ADCY7 ADCY9	2.29e-03	736	27	6	M27287
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	ADCY7 ADCY9	2.51e-03	39	27	2	MM14496
Pathway	REACTOME_SIGNALING_BY_HEDGEHOG	SYVN1 ADCY7 ADCY9	2.86e-03	150	27	3	M27440
Pathway	REACTOME_VASOPRESSIN_REGULATES_RENAL_WATER_HOMEOSTASIS_VIA_AQUAPORINS	ADCY7 ADCY9	3.04e-03	43	27	2	M933
Pathway	REACTOME_ADORA2B_MEDIATED_ANTI_INFLAMMATORY_CYTOKINES_PRODUCTION	ADCY7 ADCY9	3.04e-03	43	27	2	M29837
Pathway	REACTOME_GABA_B_RECEPTOR_ACTIVATION	ADCY7 ADCY9	3.04e-03	43	27	2	M954
Pathway	KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION	DCTN1 ADCY9	3.18e-03	44	27	2	M9011
Pathway	REACTOME_GABA_B_RECEPTOR_ACTIVATION	ADCY7 ADCY9	3.18e-03	44	27	2	MM15709
Pathway	WP_VASOPRESSINREGULATED_WATER_REABSORPTION	DCTN1 ADCY9	3.18e-03	44	27	2	M42554
Pathway	REACTOME_GPER1_SIGNALING	ADCY7 ADCY9	3.32e-03	45	27	2	M45008
Pathway	REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS	ADCY7 ADCY9	3.77e-03	48	27	2	M10775
Pathway	REACTOME_IRE1ALPHA_ACTIVATES_CHAPERONES	SYVN1 DCTN1	4.09e-03	50	27	2	M27282
Pathway	REACTOME_AQUAPORIN_MEDIATED_TRANSPORT	ADCY7 ADCY9	4.42e-03	52	27	2	M920
Pathway	WP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION	ADCY7 ADCY9	4.93e-03	55	27	2	M39763
Pathway	REACTOME_GABA_RECEPTOR_ACTIVATION	ADCY7 ADCY9	5.84e-03	60	27	2	M976
Pathway	REACTOME_GABA_RECEPTOR_ACTIVATION	ADCY7 ADCY9	5.84e-03	60	27	2	MM15708
Pathway	PID_ENDOTHELIN_PATHWAY	ADCY7 ADCY9	6.42e-03	63	27	2	M8
Pathway	PID_LYSOPHOSPHOLIPID_PATHWAY	ADCY7 ADCY9	6.82e-03	65	27	2	M15
Pathway	REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION	ADCY7 ADCY9 KPNA2	6.85e-03	205	27	3	M752
Pubmed	Higher TNFα responses in young males compared to females are associated with attenuation of monocyte adenylyl cyclase expression.	ADCY7 ADCY9	2.31e-06	3	31	2	25959651
Pubmed	Ascorbic acid is a regulator of the intracellular cAMP concentration: old molecule, new functions?	ADCY7 ADCY9	4.61e-06	4	31	2	18835269
Pubmed	Role of the calcium modulated cyclases in the development of the retinal projections.	ADCY7 ADCY9	2.76e-05	9	31	2	17229090
Pubmed	Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.	ADCY7 ADCY9	2.76e-05	9	31	2	9417641
Pubmed	Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.	ADCY7 ADCY9	2.76e-05	9	31	2	12503609
Pubmed	Purification and characterization of a soluble form of mammalian adenylyl cyclase.	ADCY7 ADCY9	3.44e-05	10	31	2	8663304
Pubmed	Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.	ADCY7 ADCY9	3.44e-05	10	31	2	11884542
Pubmed	Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain.	ADCY7 ADCY9	3.44e-05	10	31	2	16615126
Pubmed	Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.	ADCY7 ADCY9	4.21e-05	11	31	2	10089566
Pubmed	gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.	ADCY7 ADCY9	4.21e-05	11	31	2	10808179
Pubmed	Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.	ADCY7 ADCY9	4.21e-05	11	31	2	11299302
Pubmed	Expression of adenylyl cyclase mRNAs in the denervated and in the developing mouse skeletal muscle.	ADCY7 ADCY9	5.05e-05	12	31	2	9611134
Pubmed	HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.	ADCY7 ADCY9	5.05e-05	12	31	2	10807185
Pubmed	Isoforms of mammalian adenylyl cyclase: multiplicities of signaling.	ADCY7 ADCY9	6.95e-05	14	31	2	14993377
Pubmed	cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes.	ADCY7 ADCY9	8.02e-05	15	31	2	2165385
Pubmed	Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.	ADCY7 ADCY9	9.16e-05	16	31	2	17567809
Pubmed	Glucagon and regulation of glucose metabolism.	ADCY7 ADCY9	3.52e-04	31	31	2	12626323
Pubmed	RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation.	MORF4L2 KPNA2	4.75e-04	36	31	2	17573780
Pubmed	Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).	MORF4L2 ADCY7	5.02e-04	37	31	2	7584028
Pubmed	Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.	MORF4L2 ADCY7	6.79e-04	43	31	2	7584026
Interaction	LPCAT3 interactions	SLC22A6 SYVN1 HCST TCTN2	4.38e-06	80	28	4	int:LPCAT3
Interaction	ZDHHC12 interactions	SYVN1 LEMD3 ADCY7 ADCY9	2.42e-05	123	28	4	int:ZDHHC12
Interaction	VAPB interactions	FLT4 SYVN1 MORF4L2 ADCY7 TCTN2 KPNA2	3.53e-05	464	28	6	int:VAPB
Interaction	PRND interactions	PRND TEX101	6.66e-05	9	28	2	int:PRND
Interaction	SRPRB interactions	FLT4 OSMR SYVN1 LEMD3 TCTN2	8.59e-05	333	28	5	int:SRPRB
Interaction	SEC63 interactions	FLT4 SYVN1 LEMD3 ADCY9 TCTN2	1.06e-04	348	28	5	int:SEC63
Interaction	ADCY4 interactions	ADCY7 ADCY9	1.22e-04	12	28	2	int:ADCY4
Interaction	ALG5 interactions	FLT4 SYVN1 ADCY9	1.24e-04	70	28	3	int:ALG5
Interaction	CLCC1 interactions	UBR2 FLT4 SYVN1 TCTN2	1.31e-04	190	28	4	int:CLCC1
Interaction	TMEM204 interactions	FLT4 OSMR	1.44e-04	13	28	2	int:TMEM204
Interaction	ADCY7 interactions	ADCY7 ADCY9	1.68e-04	14	28	2	int:ADCY7
Interaction	STIM1 interactions	FLT4 SYVN1 LEMD3 ADCY9 TCTN2	1.76e-04	388	28	5	int:STIM1
Cytoband	Ensembl 112 genes in cytogenetic band chr17q24	ABCA8 KPNA2	2.01e-03	98	31	2	chr17q24
Cytoband	Ensembl 112 genes in cytogenetic band chr20p13	PRND RSPO4	3.15e-03	123	31	2	chr20p13
Cytoband	Ensembl 112 genes in cytogenetic band chrXq22	XKRX MORF4L2	6.04e-03	172	31	2	chrXq22
Cytoband	Ensembl 112 genes in cytogenetic band chr3q25	GMPS MFSD1	6.60e-03	180	31	2	chr3q25
GeneFamily	Adenylate cyclases\|Deafness associated genes	ADCY7 ADCY9	7.55e-05	10	24	2	53
GeneFamily	Solute carriers	SLC22A6 SLC36A1 SLC2A6 SLC35F4	1.69e-03	395	24	4	752
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	FLT4 MDGA1	1.91e-02	161	24	2	593
GeneFamily	Immunoglobulin like domain containing	FLT4 MDGA1	2.68e-02	193	24	2	594
ToppCell	Cerebellum-Neuronal-Excitatory\|Cerebellum / BrainAtlas - Mouse McCarroll V32	MDGA1 MORF4L2 SLC2A6 SLC35F4	1.85e-06	128	31	4	c30ba14320e9b98c9af9e4cd5a8c55380bb9ffa9
Drug	AC1N2DGT	ADCY7 ADCY9 ALOX15	9.05e-06	30	31	3	CID004045015
Drug	glibenclamide	SLC22A6 NPR2 FLT4 ABCA8 ADCY7 ADCY9	1.11e-05	382	31	6	CID000003488
Drug	6,7-ADTN	NPR2 ADCY7 ADCY9	1.21e-05	33	31	3	CID000003153
Drug	tetraethylammonium	SLC22A6 NPR2 FLT4 ABCA8 HCST	1.56e-05	236	31	5	CID000005413
Drug	imidazole	GMPS ENPP7 SPAG17 ADCY7 ADCY9	1.76e-05	242	31	5	CID000000795
Drug	8-bromo-cAMP	GMPS NPR2 SLC36A1 ADCY7 ADCY9	2.68e-05	264	31	5	CID000001912
Drug	ethacrynic acid	SLC22A6 FLT4 ADCY7 ADCY9	3.58e-05	138	31	4	CID000003278
Drug	zaprinast	GMPS NPR2 ADCY7 ADCY9	3.89e-05	141	31	4	CID000005722
Drug	milrinone	ENPP7 NPR2 ADCY7 ADCY9	4.96e-05	150	31	4	CID000004197
Drug	AC1L1EV8	ADCY7 ADCY9	5.00e-05	8	31	2	CID000002964
Drug	AC1L1E2H	SLC22A6 ADCY7 ADCY9	5.72e-05	55	31	3	CID000002612
Drug	AC1NE2UB	DCTN1 LEMD3 KPNA2	6.03e-05	56	31	3	CID004635684
Drug	AC1MUNZL	ADCY7 ADCY9 ALOX15	6.03e-05	56	31	3	CID003643892
Drug	14,15-dihydroforskolin	ADCY7 ADCY9	6.42e-05	9	31	2	CID000194193
Drug	ipsapirone	SLC22A6 ADCY7 ADCY9	7.80e-05	61	31	3	CID000056971
Drug	p-Aminohippuric Acid	SLC22A6 ABCA8	8.02e-05	10	31	2	ctd:D010130
Drug	2',5'-dd3'-FSBA	ADCY7 ADCY9	8.02e-05	10	31	2	CID003081206
Drug	NC-5Z	ADCY7 ADCY9	8.02e-05	10	31	2	CID003035914
Drug	papaverine	ENPP7 NPR2 ADCY7 ADCY9	9.22e-05	176	31	4	CID000004680
Drug	AC1NY9KD	ADCY7 ADCY9	9.79e-05	11	31	2	CID005771741
Drug	AC1L40QM	ADCY7 ADCY9	9.79e-05	11	31	2	CID000099213
Drug	B-Mlvp	ADCY7 ADCY9	9.79e-05	11	31	2	CID000195648
Drug	OD-q	GMPS NPR2 ADCY7 ADCY9	9.85e-05	179	31	4	CID000001456
Drug	MDL-12330A	NPR2 ADCY7 ADCY9	9.87e-05	66	31	3	CID000004024
Drug	guanosine 3',5'-cyclic monophosphoric acid	GMPS SLC22A6 NPR2 ADCY7 ADCY9 ALOX15	1.11e-04	577	31	6	CID000000295
Drug	Rp-cAMPS	SLC22A6 NPR2 ADCY7 ADCY9	1.34e-04	194	31	4	CID006426631
Drug	Pd(OAc)2	SLC36A1 SPAG17	1.39e-04	13	31	2	CID000167845
Drug	FCE 23884	ADCY7 ADCY9	1.39e-04	13	31	2	CID000065898
Drug	AC1L1BJN	ADCY7 ADCY9	1.39e-04	13	31	2	CID000001467
Drug	nantradol hydrochloride	ADCY7 ADCY9	1.39e-04	13	31	2	CID000047652
Drug	sclareol glycol	ADCY7 ADCY9	1.39e-04	13	31	2	CID000091915
Drug	Methiazole; Down 200; 15uM; MCF7; HT_HG-U133A	NPR2 FLT4 OSMR ALOX15	1.40e-04	196	31	4	3878_DN
Drug	Pseudopelletierine hydrochloride [6164-62-1]; Up 200; 21uM; MCF7; HT_HG-U133A	NPR2 FLT4 OSMR SLC2A6	1.40e-04	196	31	4	7184_UP
Drug	CP-690334-01 [459212-38-5]; Down 200; 1uM; MCF7; HT_HG-U133A	FLT4 OSMR ADCY7 ALOX15	1.48e-04	199	31	4	4383_DN
Drug	buspirone	SLC22A6 ADCY7 ADCY9	1.75e-04	80	31	3	CID000002477
Drug	SKF 75670	ADCY7 ADCY9	1.86e-04	15	31	2	CID000173870
Drug	BMY 42393	ADCY7 ADCY9	1.86e-04	15	31	2	CID000131961
Drug	AC1L2AAS	ADCY7 ADCY9	1.86e-04	15	31	2	CID000068714
Drug	benzyl alcohol	DCTN1 ADCY7 ADCY9	1.95e-04	83	31	3	CID000000244
Drug	sodium	GMPS SLC22A6 FLT4 SLC36A1 DCTN1 ADCY7 ADCY9	2.26e-04	944	31	7	CID000000923
Drug	UTP-NA	GMPS NPR2 LEMD3 ADCY7 ADCY9	2.39e-04	420	31	5	CID000001181
Drug	U754	ADCY7 ADCY9	2.41e-04	17	31	2	CID000062824
Drug	fentanyl isothiocyanate	ADCY7 ADCY9	2.41e-04	17	31	2	CID000084008
Drug	San 21009	ADCY7 ADCY9	2.41e-04	17	31	2	CID000152662
Drug	NSC95943	GMPS ADCY7 ADCY9	2.56e-04	91	31	3	CID000003044
Drug	tienilic acid	SLC22A6 ADCY7 ADCY9	2.73e-04	93	31	3	CID000038409
Drug	1,3-DCG	NPR2 ADCY7 ADCY9	2.82e-04	94	31	3	CID000150911
Drug	AC1L3XQA	ADCY7 ADCY9	3.02e-04	19	31	2	CID000124009
Drug	Ro 41-9067	ADCY7 ADCY9	3.02e-04	19	31	2	CID000125800
Drug	SK&F 82958	ADCY7 ADCY9	3.02e-04	19	31	2	ctd:C071262
Drug	quinacrine	PRND ADCY7 ADCY9 ALOX15	3.18e-04	243	31	4	CID000000237
Drug	Apolar	GMPS SLC36A1 SPAG17	3.28e-04	99	31	3	CID000012536
Drug	Dvdavp	ADCY7 ADCY9	3.36e-04	20	31	2	CID006441676
Drug	YM435	ADCY7 ADCY9	3.36e-04	20	31	2	CID000132119
Drug	6-fluoronorepinephrine	ADCY7 ADCY9	3.71e-04	21	31	2	CID000001862
Drug	reproterol	ADCY7 ADCY9	3.71e-04	21	31	2	CID000025654
Drug	chloride	SLC22A6 NPR2 FLT4 SPAG17 DCTN1 ADCY7 ADCY9	3.82e-04	1029	31	7	CID000000312
Drug	mangrove	ENPP7 NPR2 ADCY7 ADCY9 ALOX15	3.92e-04	468	31	5	CID000000965
Drug	catechol	GMPS ADCY7 ADCY9 ALOX15	3.93e-04	257	31	4	CID000000289
Drug	GSK835726	ADCY7 ADCY9	4.07e-04	22	31	2	CID005311268
Drug	octopamine	GMPS ADCY7 ADCY9	4.35e-04	109	31	3	CID000004581
Drug	beta-CNA	ADCY7 ADCY9	4.46e-04	23	31	2	CID005486190
Drug	estrone sulfate	SLC22A6 ABCA8	4.46e-04	23	31	2	ctd:C017296
Drug	Scpb	ADCY7 ADCY9	4.46e-04	23	31	2	CID000123843
Drug	NAIN	ADCY7 ADCY9	4.86e-04	24	31	2	CID000195228
Drug	trimetoquinol	ADCY7 ADCY9	4.86e-04	24	31	2	CID000005581
Drug	TL-99	ADCY7 ADCY9	4.86e-04	24	31	2	CID000122132
Drug	AC1L8VEV	ADCY7 ADCY9	4.86e-04	24	31	2	CID000433433
Drug	DEPX	ADCY7 ADCY9	4.86e-04	24	31	2	CID000001328
Drug	furosemide	SLC22A6 FLT4 ADCY7 ADCY9	4.86e-04	272	31	4	CID000003440
Drug	AC1L1AL2	ADCY7 ADCY9 ALOX15	5.09e-04	115	31	3	CID000001035
Drug	PDEs	NPR2 ADCY7 ADCY9	5.22e-04	116	31	3	CID003036959
Drug	AC1L9NB5	ADCY7 ADCY9	5.28e-04	25	31	2	CID000449609
Drug	PD 81,723	ADCY7 ADCY9	5.28e-04	25	31	2	CID000122028
Drug	octimibate	ADCY7 ADCY9	5.28e-04	25	31	2	CID000065676
Drug	N-n-propylnorapomorphine	ADCY7 ADCY9	5.28e-04	25	31	2	CID000030137
Drug	manganese-ATP	ADCY7 ADCY9	5.28e-04	25	31	2	CID000124341
Drug	tiotidine	ADCY7 ADCY9	5.28e-04	25	31	2	CID000050287
Drug	NSC186061	ADCY7 ADCY9 ALOX15	5.49e-04	118	31	3	CID000004163
Drug	7B-forskolin	ADCY7 ADCY9	5.71e-04	26	31	2	CID000130638
Drug	AC1L3WDO	PRND ALOX15	5.71e-04	26	31	2	CID000123344
Drug	metaproterenol	ADCY7 ADCY9	5.71e-04	26	31	2	CID000004086
Drug	Pf-5	PRND SPAG17	5.71e-04	26	31	2	CID000024295
Drug	hydrochlorothiazide	SLC22A6 ADCY7 ADCY9	5.76e-04	120	31	3	CID000003639
Drug	U46619	NPR2 ADCY7 ADCY9 ALOX15	5.80e-04	285	31	4	CID000005618
Drug	gluconate	SLC22A6 FLT4 ADCY7 ADCY9	5.95e-04	287	31	4	CID000000604
Drug	AC1L4MJU	NPR2 ADCY7 ADCY9 ALOX15	6.03e-04	288	31	4	CID000159822
Drug	RU 24926	ADCY7 ADCY9	6.17e-04	27	31	2	CID000122203
Drug	SM-10906	ADCY7 ADCY9	6.17e-04	27	31	2	CID006442261
Drug	probenecid	SLC22A6 ADCY7 ADCY9	6.19e-04	123	31	3	CID000004911
Drug	prenalterol	ADCY7 ADCY9	6.63e-04	28	31	2	CID000042396
Drug	tetrahydrofurfuryl alcohol	ADCY7 ADCY9	6.63e-04	28	31	2	CID000007360
Drug	desacetylnantradol	ADCY7 ADCY9	6.63e-04	28	31	2	CID000125211
Drug	butoxamine	ADCY7 ADCY9	6.63e-04	28	31	2	CID000018026
Drug	Nocloprostum	ADCY7 ADCY9	6.63e-04	28	31	2	CID006435380
Drug	angiogenesis inhibitor	RSPO4 FLT4 ADCY7	6.95e-04	128	31	3	CID002812173
Drug	tolazoline	ADCY7 ADCY9	7.12e-04	29	31	2	CID000005504
Drug	motapizone	ADCY7 ADCY9	7.12e-04	29	31	2	CID000065819
Drug	difluorophosphine	OCA2 SPAG17	7.12e-04	29	31	2	CID000139636
Drug	etazolate	ADCY7 ADCY9	7.12e-04	29	31	2	CID000003277
Disease	cerebellum white matter volume change measurement, age at assessment	SYVN1 ABCA8	1.75e-04	20	29	2	EFO_0008007, EFO_0021498

Protein segments in the cluster

Peptide	Gene	Start	Entry
GDHDCVLVLLLMPRL	DCTN1	601	Q14203
ICGPLEMLHEILLQA	NPR2	226	P20594
CILLVHVLLMPRTAA	ADCY7	606	P51828
HMFIGICLVLLVCFP	OCA2	511	Q04671
LIHILLPMVFCVLLI	OSMR	741	Q99650
VTHRLLLLCLGVVMV	LEMD3	631	Q9Y2U8
MEVTCLLLLALIPFH	MDGA1	1	Q8NFP4
MRCLPSIHPIFKLII	ALOX15	376	P16050
PHLLRLFVRIGAMLA	MORF4L2	226	Q15014
HRLLVLLLMCFLGFG	MFSD1	41	Q9H3U5
IFLGCHMVAIVPDLL	MRGPRE	71	Q86SM8
HVCRPITVALLMRLL	SLC2A6	271	Q9UGQ3
LVHCGIIEPLMNLLT	KPNA2	416	P52292
ESLIFLARLIPRMCH	GMPS	541	P49915
RLIVMVAPALCFLLV	ADCY9	141	O60503
MIHLGHILFLLLLPV	HCST	1	Q9UBK5
HVYELMCRLLGIVPE	ENPP7	386	Q6UWV6
AMELLRCPTLRHLFL	SLC22A6	326	Q4U2R8
LVDIRLHRPMCLFLC	OR10G6	71	Q8NH81
LFHCRIVSLMFLLGI	SYVN1	136	Q86TM6
MRAPLCLLLLVAHAV	RSPO4	1	Q2I0M5
IIICIGFLLMLLPEE	SLC35F4	461	A4IF30
IREEFISVPLILHCM	SPAG17	436	Q6Q759
LLLILMAGFCPLLVE	ABCA8	866	O94911
PISLLIIGIVAVHCM	SLC36A1	81	Q7Z2H8
RVTMHQPVLLCLLAL	PRND	156	Q9UKY0
VLLLLIFCNMRRPAH	FLT4	791	P35916
MGTPRIQHLLILLVL	TEX101	1	Q9BY14
FMHLILLGPVIRCLE	XKRX	101	Q6PP77
PCILDIDMFHLLVGL	UBR2	1406	Q8IWV8
MCLDIPAHLSIRILI	TCTN2	556	Q96GX1