Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	SETD1B PRDM6 PRDM2	4.53e-04	68	44	3	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	SETD1B PRDM6 PRDM2	4.73e-04	69	44	3	GO:0016278
GeneOntologyMolecularFunction	histone methyltransferase activity	SETD1B PRDM6 PRDM2	5.14e-04	71	44	3	GO:0042054
GeneOntologyMolecularFunction	protein methyltransferase activity	SETD1B PRDM6 PRDM2	1.51e-03	103	44	3	GO:0008276
GeneOntologyMolecularFunction	N-methyltransferase activity	SETD1B PRDM6 PRDM2	1.60e-03	105	44	3	GO:0008170
GeneOntologyCellularComponent	nuclear protein-containing complex	CCNT2 CHD8 TNKS SALL1 SETD1B INTS12 ARID4B CWC22 ZC3H3 RNPS1 CBX2	1.52e-04	1377	46	11	GO:0140513
Domain	Chromodomain-like	CHD8 ARID4B CBX2	6.17e-05	32	45	3	IPR016197
Domain	CHROMO	CHD8 ARID4B CBX2	6.78e-05	33	45	3	SM00298
Domain	Chromo/shadow_dom	CHD8 ARID4B CBX2	6.78e-05	33	45	3	IPR000953
Domain	WxxW_domain	MUC5B MUC5AC	8.46e-05	6	45	2	IPR025155
Domain	Mucin2_WxxW	MUC5B MUC5AC	8.46e-05	6	45	2	PF13330
Domain	SET	SETD1B PRDM6 PRDM2	1.31e-04	41	45	3	PF00856
Domain	SET	SETD1B PRDM6 PRDM2	1.85e-04	46	45	3	SM00317
Domain	SET_dom	SETD1B PRDM6 PRDM2	2.37e-04	50	45	3	IPR001214
Domain	SET	SETD1B PRDM6 PRDM2	2.37e-04	50	45	3	PS50280
Domain	TIL	MUC5B MUC5AC	3.69e-04	12	45	2	PF01826
Domain	C8	MUC5B MUC5AC	3.69e-04	12	45	2	PF08742
Domain	Unchr_dom_Cys-rich	MUC5B MUC5AC	4.35e-04	13	45	2	IPR014853
Domain	C8	MUC5B MUC5AC	4.35e-04	13	45	2	SM00832
Domain	TIL_dom	MUC5B MUC5AC	5.07e-04	14	45	2	IPR002919
Domain	Glyco_hormone_CN	MUC5B MUC5AC	5.84e-04	15	45	2	IPR006208
Domain	Cys_knot	MUC5B MUC5AC	5.84e-04	15	45	2	PF00007
Domain	VWFD	MUC5B MUC5AC	6.67e-04	16	45	2	PS51233
Domain	VWD	MUC5B MUC5AC	6.67e-04	16	45	2	SM00216
Domain	VWF_type-D	MUC5B MUC5AC	6.67e-04	16	45	2	IPR001846
Domain	VWD	MUC5B MUC5AC	6.67e-04	16	45	2	PF00094
Domain	CTCK_1	MUC5B MUC5AC	8.47e-04	18	45	2	PS01185
Domain	VWC_out	MUC5B MUC5AC	9.46e-04	19	45	2	SM00215
Domain	CT	MUC5B MUC5AC	1.27e-03	22	45	2	SM00041
Domain	Chromo_domain	CHD8 CBX2	1.51e-03	24	45	2	IPR023780
Domain	Cys_knot_C	MUC5B MUC5AC	1.64e-03	25	45	2	IPR006207
Domain	CTCK_2	MUC5B MUC5AC	1.64e-03	25	45	2	PS01225
Domain	Chromo	CHD8 CBX2	1.78e-03	26	45	2	PF00385
Domain	CHROMO_2	CHD8 CBX2	2.06e-03	28	45	2	PS50013
Domain	CHROMO_1	CHD8 CBX2	2.06e-03	28	45	2	PS00598
Domain	VWC	MUC5B MUC5AC	2.06e-03	28	45	2	PF00093
Domain	VWFC_1	MUC5B MUC5AC	3.39e-03	36	45	2	PS01208
Domain	VWC	MUC5B MUC5AC	3.78e-03	38	45	2	SM00214
Domain	VWFC_2	MUC5B MUC5AC	3.78e-03	38	45	2	PS50184
Domain	VWF_dom	MUC5B MUC5AC	4.60e-03	42	45	2	IPR001007
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	RANBP10 CHD8 SETD1B EDC4 GTF2IRD1 ZNF865 GGA1 RAI1 MPRIP CBX2	1.45e-06	1105	46	10	35748872
Pubmed	Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5).	MUC5B MUC5AC	1.71e-06	2	46	2	7513696
Pubmed	Mucin deficiency causes functional and structural changes of the ocular surface.	MUC5B MUC5AC	1.71e-06	2	46	2	23272068
Pubmed	Muc5b is mainly expressed and sialylated in the nasal olfactory epithelium whereas Muc5ac is exclusively expressed and fucosylated in the nasal respiratory epithelium.	MUC5B MUC5AC	1.71e-06	2	46	2	31030254
Pubmed	Younger patients with COME are more likely to have mucoid middle ear fluid containing mucin MUC5B.	MUC5B MUC5AC	1.71e-06	2	46	2	27729120
Pubmed	Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.	MUC5B MUC5AC	1.71e-06	2	46	2	34058148
Pubmed	The association between MUC5AC and MUC5B genes expression and remodeling progression in severe neutrophilic asthma: A direct relationship.	MUC5B MUC5AC	1.71e-06	2	46	2	37146737
Pubmed	The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium.	MUC5B MUC5AC	1.71e-06	2	46	2	23527003
Pubmed	MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions.	MUC5B MUC5AC	1.71e-06	2	46	2	14988081
Pubmed	Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric otitis media with effusion.	MUC5B MUC5AC	1.71e-06	2	46	2	16540890
Pubmed	Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions.	MUC5B MUC5AC	1.71e-06	2	46	2	15563276
Pubmed	De novo NUF2 variant in a novel inherited bone marrow failure syndrome including microcephaly and renal hypoplasia.	MUC5B MUC5AC	1.71e-06	2	46	2	36111525
Pubmed	p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA.	PPP1R12A MPRIP	1.71e-06	2	46	2	15545284
Pubmed	The expression of MUC5AC and MUC5B mucin genes in the mucosa of chronic rhinosinusitis and nasal polyposis.	MUC5B MUC5AC	1.71e-06	2	46	2	17621824
Pubmed	Muc5b is required for airway defence.	MUC5B MUC5AC	1.71e-06	2	46	2	24317696
Pubmed	Abnormalities in MUC5AC and MUC5B Protein in Airway Mucus in Asthma.	MUC5B MUC5AC	1.71e-06	2	46	2	27845589
Pubmed	Macrophages are related to goblet cell hyperplasia and induce MUC5B but not MUC5AC in human bronchus epithelial cells.	MUC5B MUC5AC	1.71e-06	2	46	2	22391959
Pubmed	C-Mannosylation of MUC5AC and MUC5B Cys subdomains.	MUC5B MUC5AC	1.71e-06	2	46	2	14718370
Pubmed	Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.	MUC5B MUC5AC	1.71e-06	2	46	2	35776514
Pubmed	Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease.	MUC5B MUC5AC	1.71e-06	2	46	2	27435107
Pubmed	The ocular surface phenotype of Muc5ac and Muc5b null mice.	MUC5B MUC5AC	1.71e-06	2	46	2	24327612
Pubmed	Mucins MUC5B and MUC5AC in Distal Airways and Honeycomb Spaces: Comparison among Idiopathic Pulmonary Fibrosis/Usual Interstitial Pneumonia, Fibrotic Nonspecific Interstitial Pneumonitis, and Control Lungs.	MUC5B MUC5AC	1.71e-06	2	46	2	26871672
Pubmed	Mucin production during prenatal and postnatal murine lung development.	MUC5B MUC5AC	1.71e-06	2	46	2	21653907
Pubmed	MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium.	MUC5B MUC5AC	1.71e-06	2	46	2	36427316
Pubmed	Increased Krüppel-like factor 12 in recurrent implantation failure impairs endometrial decidualization by repressing Nur77 expression.	KLF12 NR4A1	1.71e-06	2	46	2	28359310
Pubmed	Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin.	MUC5B MUC5AC	1.71e-06	2	46	2	32348677
Pubmed	In silico cloning of mouse Muc5b gene and upregulation of its expression in mouse asthma model.	MUC5B MUC5AC	1.71e-06	2	46	2	11587997
Pubmed	Gel-forming mucins form distinct morphologic structures in airways.	MUC5B MUC5AC	1.71e-06	2	46	2	28607090
Pubmed	Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis.	MUC5B MUC5AC	1.71e-06	2	46	2	24332705
Pubmed	Pathophysiological relevance of sputum MUC5AC and MUC5B levels in patients with mild asthma.	MUC5B MUC5AC	1.71e-06	2	46	2	34656442
Pubmed	Interleukin-33 induces mucin gene expression and goblet cell hyperplasia in human nasal epithelial cells.	MUC5B MUC5AC	5.13e-06	3	46	2	27776277
Pubmed	Autophagy of mucin granules contributes to resolution of airway mucous metaplasia.	MUC5B MUC5AC	5.13e-06	3	46	2	34158522
Pubmed	Resistin upregulates MUC5AC/B mucin gene expression in human airway epithelial cells.	MUC5B MUC5AC	5.13e-06	3	46	2	29604272
Pubmed	High-Mobility Group Box 1 Upregulates MUC5AC and MUC5B Expression in Primary Airway Epithelial Cells.	MUC5B MUC5AC	5.13e-06	3	46	2	29286856
Pubmed	IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells.	MUC5B MUC5AC	5.13e-06	3	46	2	19596978
Pubmed	Nebulized Menthol Impairs Mucociliary Clearance via TRPM8 and MUC5AC/MUC5B in Primary Airway Epithelial Cells.	MUC5B MUC5AC	5.13e-06	3	46	2	36675209
Pubmed	Regulation of neuregulin 1beta1-induced MUC5AC and MUC5B expression in human airway epithelium.	MUC5B MUC5AC	5.13e-06	3	46	2	19556605
Pubmed	Aquaporin 5 expression increases mucin production in lung adenocarcinoma.	MUC5B MUC5AC	5.13e-06	3	46	2	21455588
Pubmed	Th2 cytokines orchestrate the secretion of MUC5AC and MUC5B in IL-5-positive chronic rhinosinusitis with nasal polyps.	MUC5B MUC5AC	5.13e-06	3	46	2	29802623
Pubmed	Expression of leptin receptor in nasal polyps: leptin as a mucosecretagogue.	MUC5B MUC5AC	5.13e-06	3	46	2	20422702
Pubmed	Mucin gene polymorphisms in otitis media patients.	MUC5B MUC5AC	5.13e-06	3	46	2	19718741
Pubmed	Interaction network of human early embryonic transcription factors.	CHD8 SALL1 ARID4B PRDM6 PRDM2 RAI1	6.75e-06	351	46	6	38297188
Pubmed	CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma.	SYN2 CCNT2 RNPS1 CTTNBP2NL	7.48e-06	94	46	4	37468549
Pubmed	ILC2s mediate systemic innate protection by priming mucus production at distal mucosal sites.	MUC5B MUC5AC	1.03e-05	4	46	2	31582416
Pubmed	Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype.	MUC5B MUC5AC	1.03e-05	4	46	2	23807779
Pubmed	Inhibition of RhoA-mediated SRF activation by p116Rip.	PPP1R12A MPRIP	1.03e-05	4	46	2	16243315
Pubmed	Increased expression of MUC5AC and MUC5B promoting bacterial biofilm formation in chronic rhinosinusitis patients.	MUC5B MUC5AC	1.03e-05	4	46	2	25638393
Pubmed	Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells.	MUC5B MUC5AC	1.03e-05	4	46	2	17471237
Pubmed	MCP-1/CCR2B-dependent loop upregulates MUC5AC and MUC5B in human airway epithelium.	MUC5B MUC5AC	1.03e-05	4	46	2	21097527
Pubmed	Expression of MUC1, MUC2, MUC5AC and MUC5B in mucinous lesions of the breast.	MUC5B MUC5AC	1.03e-05	4	46	2	22269464
Pubmed	The mouse secreted gel-forming mucin gene cluster.	MUC5B MUC5AC	1.03e-05	4	46	2	14984930
Pubmed	TGF-β₂ decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells.	MUC5B MUC5AC	1.03e-05	4	46	2	23249391
Pubmed	Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse.	MUC5B MUC5AC	1.03e-05	4	46	2	12676567
Pubmed	Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells.	MUC5B MUC5AC	1.03e-05	4	46	2	29869461
Pubmed	Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways.	MUC5B MUC5AC	1.03e-05	4	46	2	18258655
Pubmed	Human transcription factor protein interaction networks.	KLF12 CHD8 SALL1 EDC4 INTS12 ARID4B ATXN7L1 PRDM2 MPRIP CBX2	1.40e-05	1429	46	10	35140242
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	CHD8 INTS12 ARID4B RNPS1 PRDM2 RAI1 CBX2	1.43e-05	608	46	7	36089195
Pubmed	Polymorphism of human mucin genes in chest disease: possible significance of MUC2.	MUC5B MUC5AC	1.71e-05	5	46	2	11062147
Pubmed	Differential expression of MUC genes in endometrial and cervical tissues and tumors.	MUC5B MUC5AC	1.71e-05	5	46	2	16188033
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	EDC4 ARID4B RNPS1 PPP1R12A RAI1 CBX2 NUFIP2	2.09e-05	645	46	7	25281560
Pubmed	Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.	MUC5B MUC5AC	2.56e-05	6	46	2	19110483
Pubmed	A germline-specific class of small RNAs binds mammalian Piwi proteins.	SYN2 ZC3H3 GGA1 RNPS1 RHOBTB2 MPRIP	2.74e-05	450	46	6	16751776
Pubmed	Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.	RASSF10 CWC22 RNPS1 CTTNBP2NL NAF1	2.87e-05	270	46	5	24366813
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	CHD8 SALL1 ARID4B CWC22 CDKN2AIP RAI1 CBX2 NUFIP2	3.22e-05	954	46	8	36373674
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	RANBP10 CHD8 TNKS EDC4 PPP1R12A RAI1 MPRIP NUFIP2	3.44e-05	963	46	8	28671696
Pubmed	MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH).	TNKS PPP1R12A	3.58e-05	7	46	2	19245366
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	CHD8 ARID4B CWC22 CTTNBP2NL PRDM2	3.65e-05	284	46	5	29459677
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	CHD8 TNKS SETD1B ARID4B RNPS1 NUFIP2	3.71e-05	475	46	6	31040226
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	CCNT2 NHS KLF12 CHD8 SALL1 SETD1B EDC4 ARID4B CDKN2AIP	5.14e-05	1327	46	9	32694731
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CCNT2 ARID4B GTF2IRD1 RNPS1 CTTNBP2NL PRDM2 NAF1	6.62e-05	774	46	7	15302935
Pubmed	Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.	MUC5B MUC5AC	9.34e-05	11	46	2	24429156
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CHD8 ARID4B ZC3H3 RNPS1 ATXN7L1 PPP1R12A RAI1 NAF1	9.68e-05	1116	46	8	31753913
Pubmed	HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.	TNKS CTTNBP2NL	1.32e-04	13	46	2	23277359
Pubmed	Pulmonary Fibrosis Predisposition Overview	MUC5B NAF1	1.32e-04	13	46	2	20301408
Pubmed	Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways.	MUC5B MUC5AC	1.54e-04	14	46	2	22797898
Pubmed	The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression.	CHD8 INTS12 RNPS1	1.91e-04	84	46	3	26299517
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	EDC4 RNPS1 CDKN2AIP PPP1R12A NAF1 MPRIP NUFIP2	2.12e-04	934	46	7	33916271
Pubmed	Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor.	SERTAD4 NR4A1 MPRIP	2.50e-04	92	46	3	20368287
Pubmed	Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.	MUC5B MUC5AC	2.58e-04	18	46	2	18834073
Pubmed	USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier.	CHD8 GTF2IRD1	2.58e-04	18	46	2	17846119
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	CHD8 SALL1 CTTNBP2NL CDKN2AIP NUFIP2	2.95e-04	444	46	5	34795231
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	RANBP10 GGA1 MUC5AC RNF126 PPP1R12A NAF1 MPRIP NUFIP2	3.06e-04	1321	46	8	27173435
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	CWC22 CDKN2AIP PPP1R12A NAF1 MPRIP NUFIP2	3.10e-04	701	46	6	30196744
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	RNPS1 PPP1R12A MPRIP NUFIP2	3.62e-04	255	46	4	15324660
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	CHD8 INTS12 RNPS1 RAI1	4.36e-04	268	46	4	33640491
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	CCNT2 CHD8 EDC4 INTS12 CDKN2AIP PRDM2 RAI1	5.75e-04	1103	46	7	34189442
Pubmed	Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes.	SALL1 NR4A1	6.33e-04	28	46	2	27076431
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	CCNT2 RANBP10 CHD8 CWC22 NAF1	6.77e-04	533	46	5	30554943
Pubmed	Biological insights from 108 schizophrenia-associated genetic loci.	RANBP10 CD46 EDC4 RAI1	6.91e-04	303	46	4	25056061
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CHD8 EDC4 INTS12 CTTNBP2NL CDKN2AIP PPP1R12A MPRIP NUFIP2	7.01e-04	1497	46	8	31527615
Pubmed	Identification of 14-3-3epsilon substrates from embryonic murine brain.	SYN2 DCLK2 MPRIP	7.20e-04	132	46	3	16944949
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	CD46 GTF2IRD1 TPBG NUFIP2	7.26e-04	307	46	4	37499664
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	CHD8 EDC4 PPP1R12A MPRIP NUFIP2	7.74e-04	549	46	5	38280479
Pubmed	ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.	EDC4 CWC22 CTTNBP2NL NUFIP2	7.98e-04	315	46	4	26777405
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	SALL1 INTS12 ARID4B PRDM6 PPP1R12A FOXF2	8.89e-04	857	46	6	25609649
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	NHS DCLK2 EDC4 INTS12 PPP1R12A MPRIP	9.11e-04	861	46	6	36931259
Pubmed	Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos.	CHD8 GTF2IRD1	9.35e-04	34	46	2	7490078
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	CCNT2 CHD8 TNKS CD46 RNPS1 TPBG NUFIP2	9.58e-04	1203	46	7	29180619
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	EDC4 CDKN2AIP PPP1R12A MPRIP	1.06e-03	340	46	4	24332808
Pubmed	A protein interaction framework for human mRNA degradation.	EDC4 GTF2IRD1 CWC22 RNPS1	1.14e-03	347	46	4	15231747
Interaction	PLCD3 interactions	RANBP10 CHD8 CWC22 RNPS1 PPP1R12A NAF1	3.18e-07	121	46	6	int:PLCD3
Interaction	PIP4K2A interactions	CHD8 SETD1B EDC4 CWC22 RNPS1 NAF1 NUFIP2	5.53e-07	216	46	7	int:PIP4K2A
Interaction	CT45A5 interactions	RANBP10 CHD8 EDC4 CWC22 NAF1	9.23e-07	78	46	5	int:CT45A5
Interaction	FAM9A interactions	INTS12 CWC22 RNPS1 NAF1	9.86e-06	59	46	4	int:FAM9A
Interaction	NUP43 interactions	CCNT2 CHD8 SETD1B ARID4B CWC22 RNPS1 CDKN2AIP PPP1R12A PRDM2	9.89e-06	625	46	9	int:NUP43
Interaction	UPF1 interactions	NR4A1 EDC4 ZC3H3 RNPS1 ATXN7L1 PPP1R12A RHOBTB2 NUFIP2	4.51e-05	581	46	8	int:UPF1
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETD1B PRDM6 PRDM2	2.38e-05	34	30	3	487
GeneFamily	Zinc fingers C2H2-type\|PR/SET domain family	PRDM6 PRDM2	3.56e-04	17	30	2	1197
GeneFamily	CD molecules\|Mucins	MUC5B MUC5AC	5.48e-04	21	30	2	648
Coexpression	GSE7509_UNSTIM_VS_FCGRIIB_STIM_MONOCYTE_DN	CCNT2 DCLK2 EDC4 ARID4B GTF2IRD1 PRDM2	4.48e-07	166	46	6	M6826
Coexpression	GSE37532_VISCERAL_ADIPOSE_TISSUE_VS_LN_DERIVED_PPARG_KO_TREG_CD4_TCELL_DN	RASSF10 RANBP10 SETD1B GGA1 RNF126	4.49e-06	139	46	5	M8948
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_emap-3087_top-relative-expression-ranked_1000	SERTAD4 SYN2 SHE SALL1 NR4A1 PRDM6 FOXF2 TPBG MPRIP NUFIP2	7.03e-06	827	45	10	gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_emap-30875_k-means-cluster#2_top-relative-expression-ranked_500	SERTAD4 FOXF2 TPBG NUFIP2	1.82e-05	74	45	4	gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_500_k2
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_emap-3087_top-relative-expression-ranked_500	SERTAD4 SYN2 SHE SALL1 NR4A1 FOXF2 NUFIP2	2.84e-05	424	45	7	gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_500
Drug	Thioperamide maleate [106243-16-7]; Up 200; 9.8uM; MCF7; HT_HG-U133A	SYN2 MUC5B SALL1 SETD1B NR4A1 AJAP1	2.28e-06	191	46	6	3392_UP
Disease	pulmonary fibrosis	MUC5B MUC5AC	1.30e-04	11	46	2	EFO_0009448
Disease	goiter	FAM227B SALL1	5.89e-04	23	46	2	EFO_0004283
Disease	wellbeing measurement	RASSF10 SYN2 TNKS KLHL1 NAF1 TPBG	6.86e-04	692	46	6	EFO_0007869
Disease	word list delayed recall measurement, memory performance	KLHL1 AJAP1	1.22e-03	33	46	2	EFO_0004874, EFO_0006805
Disease	COVID-19 symptoms measurement	MUC5B MUC5AC	1.37e-03	35	46	2	EFO_0600019
Disease	smoking status measurement, systolic blood pressure	RASSF10 TNKS AJAP1	1.86e-03	156	46	3	EFO_0006335, EFO_0006527
Disease	Alzheimer's disease biomarker measurement	CDKN2AIP RHOBTB2	2.56e-03	48	46	2	EFO_0006514
Disease	Myopia	KLHL1 AJAP1 TCP11L2 CDKN2AIP	3.02e-03	385	46	4	HP_0000545
Disease	idiopathic pulmonary fibrosis	MUC5B MUC5AC	3.59e-03	57	46	2	EFO_0000768
Disease	pancreatic ductal carcinoma (is_marker_for)	MUC5B MUC5AC	4.10e-03	61	46	2	DOID:3587 (is_marker_for)
Disease	chronic obstructive pulmonary disease	RASSF10 SYN2 RANBP10 FAM227B INTS12	4.23e-03	688	46	5	EFO_0000341
Disease	cystic fibrosis (is_marker_for)	MUC5B MUC5AC	4.24e-03	62	46	2	DOID:1485 (is_marker_for)
Disease	cholangiocarcinoma (is_marker_for)	MUC5B MUC5AC	4.51e-03	64	46	2	DOID:4947 (is_marker_for)
Disease	interstitial lung disease	MUC5B MUC5AC	4.93e-03	67	46	2	EFO_0004244
Disease	severe acute respiratory syndrome, COVID-19	KLF12 KLHL1 AJAP1 PRDM6	5.13e-03	447	46	4	EFO_0000694, MONDO_0100096
Disease	Intellectual Disability	CHD8 PPP1R12A RHOBTB2 RAI1	5.13e-03	447	46	4	C3714756

Protein segments in the cluster

Peptide	Gene	Start	Entry
SAATSSSSSSPSSSS	ARID4B	1271	Q4LE39
SSLSPSSTASSSLTS	CTTNBP2NL	411	Q9P2B4
SSTASSSLTSSPCSS	CTTNBP2NL	416	Q9P2B4
SLSSSSSSSPSSTDN	FAM227B	486	Q96M60
SKLSPSSSSSSSSSS	CHD8	2076	Q9HCK8
KSSKSSGSSSSSSSS	CCNT2	636	O60583
SSPSLASSSSSSSSA	AJAP1	126	Q9UKB5
KPQSSTSSSSSSSSS	ATXN7L1	646	Q9ULK2
ATTPTATSSKATSSS	MUC5B	4286	Q9HC84
STSSSTASSCSSSPR	RASSF10	201	A6NK89
KPSSSASSSSSSSSF	RAI1	1626	Q7Z5J4
PAPSSSSSSSSSSSS	RANBP10	406	Q6VN20
SPSSSSSGSSSSSSS	EDC4	611	Q6P2E9
TTSKTTSESSSSPSA	INTS12	416	Q96CB8
SSTSSSSATSPASAS	NR4A1	86	P22736
SSSSSSSSSIPSAEK	MPRIP	181	Q6WCQ1
VSTSSTTKSPASSAS	CD46	301	P15529
SSPSSSSSASSSSES	CWC22	666	Q9HCG8
SSQTSTSQLPSKSTS	CDKN2AIP	401	Q9NXV6
SSQLSTPKSTKSSSS	DCLK2	326	Q8N568
SSSSSFSISSSSSPS	CSNKA2IP	641	A0A1B0GTH6
KSSSCSSPSSSATSL	GGA1	461	Q9UJY5
PQTSKTSAATSSTTS	MUC5AC	3466	P98088
SSTPQTSKTSAATSS	MUC5AC	3896	P98088
STPASSSTSASSASS	PRDM6	81	Q9NQX0
PSKSKSSSSSSSSTS	CBX2	101	Q14781
SASSPSSTSTSSSSS	KLF12	106	Q9Y4X4
VSSSSSSSSSSSSNP	GTF2IRD1	911	Q9UHL9
STAPSSSSSSSSSSG	SALL1	146	Q9NSC2
SSSFSSSSSSSSPSP	PRDM2	1061	Q13029
APETTSSSSSSSSAS	FOXF2	41	Q12947
SSSSSSSSSSSAPQR	SYN2	486	Q92777
TSRSSSSSSSSGSPS	RNPS1	111	Q15287
ASDSSSKSSSPASTS	TCP11L2	41	Q8N4U5
SSSSSASSITSPSSN	NHS	1476	Q6T4R5
SSSAASSSSPSSSSA	RHOBTB2	711	Q9BYZ6
SSSSSSSSSSSPSNE	RNF126	291	Q9BV68
SSSASSSSGSSTTSP	SETD1B	1046	Q9UPS6
SSSGSSTTSPSSSAS	SETD1B	1051	Q9UPS6
AASSPSASSSSSSSS	SERTAD4	216	Q9NUC0
SPSSSKASSSSSSSS	ZC3H3	866	Q8IXZ2
KASSSSSSSSSPPAS	ZC3H3	871	Q8IXZ2
VPSSSSSSSSSSSSS	ZNF865	91	P0CJ78
SSSSSSSSSSSSQAK	ZNF865	106	P0CJ78
QNSSVSPTSSSSSSS	NUFIP2	371	Q7Z417
SSSSPTSSSSSSPSS	TNKS	131	O95271
SSPSSSSSTSSPSSS	TPRXL	81	Q17RH7
SPSSSSSSSSSSSPS	TPRXL	91	Q17RH7
SSSSSSSSPSSSNSS	TPRXL	96	Q17RH7
SSSPSSSNSSSSSSS	TPRXL	101	Q17RH7
SSNSSSSSSSSSPSS	TPRXL	106	Q17RH7
SSPSSSSSSSSSSPS	TPRXL	116	Q17RH7
SSSPSSSSSSPSSSS	TPRXL	126	Q17RH7
PSSSSSSSSSSPSSS	TPRXL	136	Q17RH7
SSSSSSPSSSSSSPS	TPRXL	141	Q17RH7
SPSSSSSSPSSSSSS	TPRXL	146	Q17RH7
SSSSSSSPSSSSPSS	TPRXL	161	Q17RH7
SSSNSSPSSSSSSPS	TPRXL	181	Q17RH7
SPSSSSSSPSSSSSS	TPRXL	186	Q17RH7
SSPSSSSSSTSSPST	TPRXL	206	Q17RH7
SSSSTSSPSTSSPSS	TPRXL	211	Q17RH7
SSSPTSSASSFSSSA	TPBG	31	Q13641
YPSSSSSSSSSSSSA	SHE	161	Q5VZ18
KPSSSSSSSSSPSSS	KLHL1	71	Q9NR64
SSSSSSPSSSSSSFN	KLHL1	76	Q9NR64
SSSSSSSSSSCISLP	NAF1	136	Q96HR8
SSTTPSSSLSTMSSS	PPP1R12A	776	O14974