Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion binding	LPCAT1 PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 ACTN4 ACTN3 PCDHB16 PCDHB18P TGM2 PCDHGA12	1.70e-05	749	98	14	GO:0005509
GeneOntologyMolecularFunction	H3K9me3 modified histone binding	KDM4C DPF2	1.42e-04	4	98	2	GO:0062072
GeneOntologyMolecularFunction	nuclear receptor coactivator activity	NCOA2 KDM4C ACTN4 NCOA7	2.30e-04	61	98	4	GO:0030374
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHB18P PCDHGA12	1.53e-08	187	95	10	GO:0007156
GeneOntologyBiologicalProcess	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHGA12	1.57e-07	53	95	6	GO:0016339
GeneOntologyBiologicalProcess	cell-cell adhesion via plasma-membrane adhesion molecules	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 ADGRL1 PCDHB16 PCDHB18P PCDHGA12	2.07e-07	313	95	11	GO:0098742
GeneOntologyBiologicalProcess	cell junction assembly	GABRB3 MYCBP2 PCDHB5 WNT11 PCDHB13 PCDHB8 PCDHB3 ADGRL1 ACTN4 ACTN3 PCDHB16 CAPRIN1	1.18e-05	569	95	12	GO:0034329
GeneOntologyBiologicalProcess	synapse assembly	GABRB3 MYCBP2 PCDHB5 PCDHB13 PCDHB8 PCDHB3 ADGRL1 PCDHB16 CAPRIN1	1.25e-05	308	95	9	GO:0007416
GeneOntologyBiologicalProcess	double-strand break repair via break-induced replication	MCM4 CDC7 CDC45	2.02e-05	12	95	3	GO:0000727
GeneOntologyBiologicalProcess	cell junction organization	GABRB3 MYCBP2 PCDHB5 WNT11 PCDHB13 PCDHB8 PCDHB3 ADGRL1 ACTN4 ACTN3 SHISA7 PCDHB16 GPR158 PRMT3 CAPRIN1	3.72e-05	974	95	15	GO:0034330
GeneOntologyBiologicalProcess	synapse organization	GABRB3 MYCBP2 PCDHB5 PCDHB13 PCDHB8 PCDHB3 ADGRL1 SHISA7 PCDHB16 GPR158 PRMT3 CAPRIN1	7.19e-05	685	95	12	GO:0050808
GeneOntologyCellularComponent	pseudopodium	ACTN4 ACTN3 MAPK3	7.51e-05	18	97	3	GO:0031143
GeneOntologyCellularComponent	9+0 motile cilium	ODAD4 DNAH11	3.16e-04	6	97	2	GO:0097728
Domain	Cadherin_C	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHGA12	6.01e-13	42	95	9	IPR032455
Domain	Cadherin_C_2	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHGA12	6.01e-13	42	95	9	PF16492
Domain	Cadherin_2	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHGA12	3.91e-11	65	95	9	PF08266
Domain	Cadherin_N	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHGA12	3.91e-11	65	95	9	IPR013164
Domain	Cadherin_CS	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHGA12	4.35e-09	109	95	9	IPR020894
Domain	CADHERIN_1	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHGA12	5.99e-09	113	95	9	PS00232
Domain	Cadherin	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHGA12	5.99e-09	113	95	9	PF00028
Domain	CADHERIN_2	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHGA12	6.47e-09	114	95	9	PS50268
Domain	-	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHGA12	6.47e-09	114	95	9	2.60.40.60
Domain	CA	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHGA12	6.99e-09	115	95	9	SM00112
Domain	Cadherin-like	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHGA12	7.55e-09	116	95	9	IPR015919
Domain	Cadherin	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHGA12	8.78e-09	118	95	9	IPR002126
Domain	Cadherin_tail	PCDHGB6 PCDHGA4 PCDHGA3 PCDHGA12	3.65e-05	37	95	4	PF15974
Domain	Cadherin_CBD	PCDHGB6 PCDHGA4 PCDHGA3 PCDHGA12	3.65e-05	37	95	4	IPR031904
Domain	EF-hand_Ca_insen	ACTN4 ACTN3	3.79e-04	6	95	2	IPR014837
Domain	EFhand_Ca_insen	ACTN4 ACTN3	3.79e-04	6	95	2	PF08726
Domain	TPR	SH3TC2 ODAD4 TTC1 IFIT2 LONRF3	5.13e-04	129	95	5	SM00028
Domain	TPR_repeat	SH3TC2 ODAD4 TTC1 IFIT2 LONRF3	5.89e-04	133	95	5	IPR019734
Domain	-	SH3TC2 ODAD4 TTC1 RMDN2 IFIT2 LONRF3	6.60e-04	207	95	6	1.25.40.10
Domain	TPR-contain_dom	SH3TC2 ODAD4 TTC1 IFIT2 LONRF3	1.01e-03	150	95	5	IPR013026
Domain	TPR-like_helical_dom	SH3TC2 ODAD4 TTC1 RMDN2 IFIT2 LONRF3	1.22e-03	233	95	6	IPR011990
Domain	TPR_REGION	SH3TC2 ODAD4 TTC1 IFIT2 LONRF3	1.55e-03	165	95	5	PS50293
Domain	TPR	SH3TC2 ODAD4 TTC1 IFIT2 LONRF3	1.55e-03	165	95	5	PS50005
Domain	TPR_8	ODAD4 TTC1 IFIT2	2.48e-03	53	95	3	PF13181
Domain	DH_1	NET1 ARHGEF5 ARHGEF17	4.06e-03	63	95	3	PS00741
Domain	RhoGEF	NET1 ARHGEF5 ARHGEF17	5.03e-03	68	95	3	SM00325
Domain	RhoGEF	NET1 ARHGEF5 ARHGEF17	5.46e-03	70	95	3	PF00621
Domain	DH_2	NET1 ARHGEF5 ARHGEF17	5.46e-03	70	95	3	PS50010
Domain	GRAM	TBC1D8 NCOA7	5.53e-03	22	95	2	PF02893
Domain	GRAM	TBC1D8 NCOA7	5.53e-03	22	95	2	IPR004182
Domain	DH-domain	NET1 ARHGEF5 ARHGEF17	5.68e-03	71	95	3	IPR000219
Domain	-	NET1 ARHGEF5 ARHGEF17	5.68e-03	71	95	3	1.20.900.10
Domain	Actinin_actin-bd_CS	ACTN4 ACTN3	6.04e-03	23	95	2	IPR001589
Domain	Spectrin	ACTN4 ACTN3	6.04e-03	23	95	2	PF00435
Domain	ACTININ_2	ACTN4 ACTN3	6.04e-03	23	95	2	PS00020
Domain	ACTININ_1	ACTN4 ACTN3	6.04e-03	23	95	2	PS00019
Domain	Metal_Hydrolase	ADA TATDN3	6.57e-03	24	95	2	IPR032466
Domain	Spectrin_repeat	ACTN4 ACTN3	9.51e-03	29	95	2	IPR002017
Domain	SH3_2	SH3TC2 ARHGEF5 MIA2	9.62e-03	86	95	3	IPR011511
Domain	SH3_2	SH3TC2 ARHGEF5 MIA2	9.62e-03	86	95	3	PF07653
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHB18P PCDHGA12	5.00e-15	68	98	10	11230163
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHB18P PCDHGA12	9.14e-15	72	98	10	10380929
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHB18P PCDHGA12	1.22e-14	74	98	10	10817752
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHB18P PCDHGA12	1.85e-14	77	98	10	10835267
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHB18P PCDHGA12	2.75e-14	80	98	10	10716726
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHB18P PCDHGA12	6.18e-14	57	98	9	32633719
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHB18P	5.07e-12	58	98	8	30377227
Pubmed	The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number.	PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHB18P	1.61e-11	20	98	6	11322959
Pubmed	Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice.	PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16	1.54e-10	28	98	6	33523829
Pubmed	Protocadherins.	PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16	2.03e-10	13	98	5	12231349
Pubmed	Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin.	MCM4 CDC7 CDC45	2.17e-08	3	98	3	17046832
Pubmed	A unique role of cohesin-SA1 in gene regulation and development.	PCDHB13 PCDHB8 PCDHB16 PCDHB18P	1.05e-07	16	98	4	22415368
Pubmed	Postsynaptic and differential localization to neuronal subtypes of protocadherin beta16 in the mammalian central nervous system.	PCDHB5 PCDHB13 PCDHB8 PCDHB3	1.37e-07	17	98	4	18279309
Pubmed	Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome.	PCDHB13 PCDHB8 PCDHB16 PCDHB18P	2.22e-07	19	98	4	23920377
Pubmed	Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.	RPS6KA2 BCOR CDC45 CSNK2A2 NAT10 MAPK3 MORC3	3.72e-07	160	98	7	31678930
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	NCOA2 MYCBP2 MCM4 ACTN4 DPF2 PFKM BCOR DNTTIP1 STRAP PRRC2C CSNK2A2 SYK CTPS1 CAPRIN1 ZMYM4	4.69e-07	1103	98	15	34189442
Pubmed	Differential expression of individual gamma-protocadherins during mouse brain development.	PCDHGA4 PCDHGA3 PCDHGA12	7.53e-07	7	98	3	15964765
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	MCM4 DPF2 CNTROB CACTIN STRAP PRRC2C CSNK2A2 HTATSF1 MORC3 ZMYM4	8.78e-07	469	98	10	27634302
Pubmed	Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems.	PCDHB13 PCDHB8 PCDHB3	2.57e-06	10	98	3	22969705
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NCOA2 MYCBP2 RPS6KA2 BCOR SHISA7 STRAP GPR158 PRRC2C CSNK2A2 NAT10 DIAPH2 MAPK3 CAPRIN1	3.18e-06	963	98	13	28671696
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	NCOA2 MYCBP2 RPS6KA2 UVSSA ADGRL1 E2F3 ARHGAP35 PCDHB16 DNTTIP1 TATDN3 SYNJ2 GPR158 NAT10 ADI1 ABLIM2 ZMYM4	4.05e-06	1489	98	16	28611215
Pubmed	Maturation of postnatally generated olfactory bulb granule cells depends on functional γ-protocadherin expression.	PCDHGA4 PCDHGA3 PCDHGA12	9.63e-06	15	98	3	23515096
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	LPCAT1 WNT11 MCM4 ACTN4 PFKM ARHGAP35 MIA2 STRAP PRRC2C CSNK2A2 HTATSF1 ADI1 NME1 CTPS1 CAPRIN1	9.85e-06	1415	98	15	28515276
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	GABRB3 ADGRL1 ACTN4 ACTN3 PFKM ARHGAP35 ARHGEF17 PIK3R4 PRRC2C CSNK2A2 MAPK3 ABLIM2 CAPRIN1 HSDL1 DNAH11	1.13e-05	1431	98	15	37142655
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	MCM4 PFKM ARHGAP35 BCOR TTC1 STRAP PRRC2C NAT10 HTATSF1 NCOA7 NME1 CTPS1	1.28e-05	934	98	12	33916271
Pubmed	Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures.	MCM4 CDC7 CDC45	2.03e-05	19	98	3	15226314
Pubmed	Contribution of casein kinase 2 and spleen tyrosine kinase to CFTR trafficking and protein kinase A-induced activity.	CSNK2A2 SYK	2.35e-05	3	98	2	21930781
Pubmed	α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse.	ACTN4 ACTN3	2.35e-05	3	98	2	21784188
Pubmed	Transglutaminase 2 and nucleoside diphosphate kinase activity are correlated in epithelial membranes and are abnormal in cystic fibrosis.	TGM2 NME1	2.35e-05	3	98	2	19619546
Pubmed	The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells.	ACTN4 ACTN3	2.35e-05	3	98	2	10656685
Pubmed	Biochemical activities associated with mouse Mcm2 protein.	MCM4 CDC7	2.35e-05	3	98	2	11568184
Pubmed	Suppression of Spleen Tyrosine Kinase (Syk) by Histone Deacetylation Promotes, Whereas BAY61-3606, a Synthetic Syk Inhibitor Abrogates Colonocyte Apoptosis by ERK Activation.	SYK MAPK3	2.35e-05	3	98	2	27293079
Pubmed	Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase.	CDC7 CDC45	2.35e-05	3	98	2	19054765
Pubmed	Activation of human neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin.	ACTN4 ACTN3	2.35e-05	3	98	2	8104223
Pubmed	Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.	MCM4 CDC7 CDC45	2.39e-05	20	98	3	12614612
Pubmed	Defining the membrane proteome of NK cells.	LPCAT1 MYCBP2 MCM4 PIK3R4 SERPINB9 MIA2 PRRC2C NAT10 APOL3 NME1 CTPS1 CAPRIN1 CYB5R1	2.47e-05	1168	98	13	19946888
Pubmed	Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.	ACTN4 CDC45 IVNS1ABP STRAP HTATSF1 MAPK3 NME1 CTPS1	2.50e-05	418	98	8	32552912
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	NCOA2 MYCBP2 ARHGAP35 BCOR STRAP PRRC2C NAT10 CTPS1 ZMYM4	2.58e-05	549	98	9	38280479
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	NET1 MYCBP2 ARHGEF5 RPS6KA2 ARHGEF17 PIK3R4 IVNS1ABP SYNJ2 PRRC2C NCOA7 MORC3	3.18e-05	861	98	11	36931259
Pubmed	DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system.	MCM4 CDC7 CDC45	3.21e-05	22	98	3	15707391
Pubmed	Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.	PCDHGA3 PCDHB5 PCDHB3	4.21e-05	24	98	3	24698270
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	NCOA2 E2F3 BCOR CDC7 TBC1D8 PRRC2C MORC3 ZMYM4 TOP3A	4.40e-05	588	98	9	38580884
Pubmed	Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex.	MCM4 CDC7	4.70e-05	4	98	2	20421204
Pubmed	Clustering of Genetic Anomalies of Cilia Outer Dynein Arm and Central Apparatus in Patients with Transposition of the Great Arteries.	ODAD4 DNAH11	4.70e-05	4	98	2	36140829
Pubmed	Syk is required for BCR-mediated activation of p90Rsk, but not p70S6k, via a mitogen-activated protein kinase-independent pathway in B cells.	SYK MAPK3	4.70e-05	4	98	2	9218456
Pubmed	Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network.	ACTN4 ACTN3	4.70e-05	4	98	2	1629252
Pubmed	Disruption of alpha-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis.	ACTN4 ACTN3	4.70e-05	4	98	2	16807302
Pubmed	The tyrosine kinase Syk promotes phagocytosis of Francisella through the activation of Erk.	SYK MAPK3	4.70e-05	4	98	2	18295889
Pubmed	Severity of Demyelinating and Axonal Neuropathy Mouse Models Is Modified by Genes Affecting Structure and Function of Peripheral Nodes.	SH3TC2 SCN8A	4.70e-05	4	98	2	28355569
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	MYCBP2 MCM4 CDC7 STRAP COG1 PRRC2C NME1 CAPRIN1 HSDL1	5.54e-05	606	98	9	36538041
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	MCM4 ACTN4 STRAP PRRC2C CSNK2A2 HTATSF1 NME1 CTPS1 CAPRIN1	5.61e-05	607	98	9	39147351
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ARHGEF5 E2F3 BCOR DNTTIP1 CACTIN CSNK2A2 NAT10 MORC3 ZMYM4	5.68e-05	608	98	9	36089195
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	MYCBP2 PCDHB5 ODAD4 PIK3R4 CACTIN STRAP CSNK2A2 NAT10 HTATSF1 ADI1 CTPS1 CAPRIN1 HSDL1	6.51e-05	1284	98	13	17353931
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	NCOA2 MYCBP2 KDM4C E2F3 ACTN4 MOAP1 MSTO1 PIK3R4 MIA2 COG1 MORC3 CAPRIN1 ZMYM4	6.56e-05	1285	98	13	35914814
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHGA4 PCDHGA3 PCDHGA12	6.75e-05	28	98	3	15347688
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MYCBP2 MCM4 DPF2 ARHGAP35 BCOR CACTIN CSNK2A2 MAPK3 CTPS1 ZMYM4	6.76e-05	774	98	10	15302935
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	MYCBP2 PDSS1 PFKM TTC1 RMDN2 CDC45 MIA2 MTRFR NAT10 NME1 CAPRIN1 HSDL1 TOP3A CYB5R1	7.75e-05	1496	98	14	32877691
Pubmed	STRAP and NME1 Mediate the Neurite Growth-Promoting Effects of the Neurotrophic Factor GDF5.	STRAP NME1	7.82e-05	5	98	2	32853992
Pubmed	Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis.	LPCAT1 MAPK3	7.82e-05	5	98	2	37875967
Pubmed	Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo.	RPS6KA2 MAPK3	7.82e-05	5	98	2	9915826
Pubmed	Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner.	ACTN4 ACTN3	7.82e-05	5	98	2	15841212
Pubmed	A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination.	CSNK2A2 HTATSF1	7.82e-05	5	98	2	35597237
Pubmed	The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery.	MCM4 CDC7	7.82e-05	5	98	2	27757957
Pubmed	Melanoma antigen gene protein-A11 (MAGE-11) F-box links the androgen receptor NH2-terminal transactivation domain to p160 coactivators.	NCOA2 MAPK3	7.82e-05	5	98	2	19828458
Pubmed	The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin.	ACTN4 ACTN3	7.82e-05	5	98	2	12837758
Pubmed	Cell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interaction.	ACTN4 ACTN3	7.82e-05	5	98	2	19943616
Pubmed	Stimulation of macrophage Fc gamma RIIIA activates the receptor-associated protein tyrosine kinase Syk and induces phosphorylation of multiple proteins including p95Vav and p62/GAP-associated protein.	ARHGAP35 SYK	7.82e-05	5	98	2	8189062
Pubmed	Activation of extracellular signal-regulated kinase through B-cell antigen receptor in B-cell chronic lymphocytic leukemia.	SYK MAPK3	7.82e-05	5	98	2	12095152
Pubmed	Self-assembling protein microarrays.	MCM4 CDC7 CDC45	8.33e-05	30	98	3	15232106
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	NCOA2 PCDHB13 PCDHB8 XPA BCOR NAT10 CAPRIN1	8.94e-05	371	98	7	15747579
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	LPCAT1 MCM4 ACTN4 ACTN3 TGM2 STRAP PRRC2C NME1 CTPS1	9.12e-05	647	98	9	26618866
Pubmed	Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome.	RARG CDC45 THAP12	9.21e-05	31	98	3	15778864
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	MCM4 ACTN3 BCOR SYNJ2 PRRC2C CSNK2A2 NAT10 CTPS1 CAPRIN1	1.12e-04	665	98	9	30457570
Pubmed	Phosphorylation of HIV-1 Rev protein: implication of protein kinase CK2 and pro-directed kinases.	CSNK2A2 MAPK3	1.17e-04	6	98	2	8806671
Pubmed	Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.	ACTN4 ACTN3	1.17e-04	6	98	2	18425115
Pubmed	Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.	RPS6KA2 MAPK3	1.17e-04	6	98	2	12832467
Pubmed	CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components.	ODAD4 DNAH11	1.17e-04	6	98	2	33347437
Pubmed	The Alström syndrome protein, ALMS1, interacts with α-actinin and components of the endosome recycling pathway.	ACTN4 ACTN3	1.17e-04	6	98	2	22693585
Pubmed	The MAP kinase ERK5 binds to and phosphorylates p90 RSK.	RPS6KA2 MAPK3	1.17e-04	6	98	2	16626623
Pubmed	Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases.	RPS6KA2 MAPK3	1.17e-04	6	98	2	8939914
Pubmed	Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.	MCM4 CDC7 CDC45	1.22e-04	34	98	3	12791985
Pubmed	Functional significance of isoform diversification in the protocadherin gamma gene cluster.	PCDHGA4 PCDHGA3 PCDHGA12	1.22e-04	34	98	3	22884324
Pubmed	STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells.	CDC7 MIA2 STRAP	1.45e-04	36	98	3	33230114
Pubmed	Subdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylation.	CDC45 MAPK3	1.64e-04	7	98	2	14625311
Pubmed	Syk kinases are required for spinal commissural axon repulsion at the midline via the ephrin/Eph pathway.	SYK MAPK3	1.64e-04	7	98	2	27122172
Pubmed	Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication.	CDC7 CDC45	1.64e-04	7	98	2	30392930
Pubmed	Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion.	SYK MAPK3	1.64e-04	7	98	2	18356083
Pubmed	Hyperphosphorylation of the retinoid X receptor alpha by activated c-Jun NH2-terminal kinases.	RARG MAPK3	1.64e-04	7	98	2	10383391
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	CCDC28A XPA TTC1 CNTROB DNTTIP1 CDC7 PIK3R4 STRAP CSNK2A2 GSTCD PRMT3	1.67e-04	1038	98	11	26673895
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	MYCBP2 ARHGEF5 ARHGEF17 SYNJ2	2.04e-04	102	98	4	15778465
Pubmed	Neogenin regulates skeletal myofiber size and focal adhesion kinase and extracellular signal-regulated kinase activities in vivo and in vitro.	RPS6KA2 MAPK3	2.18e-04	8	98	2	19812254
Pubmed	The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism.	CDC7 CDC45	2.18e-04	8	98	2	16912045
Pubmed	Mice deficient in alpha-actinin-4 have severe glomerular disease.	ACTN4 ACTN3	2.18e-04	8	98	2	12782671
Pubmed	Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.	MCM4 CDC7	2.18e-04	8	98	2	16899510
Pubmed	CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function.	ACTN4 ACTN3	2.18e-04	8	98	2	20215401
Pubmed	Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction.	WNT11 MAPK3	2.18e-04	8	98	2	15691764
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	MCM4 ACTN4 PFKM TTC1 IVNS1ABP TGM2 STRAP CSNK2A2 HTATSF1 NCOA7 PRMT3 NME1 CTPS1	2.24e-04	1455	98	13	22863883
Pubmed	The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety.	NCOA2 BCOR NAT10	2.47e-04	43	98	3	26487511
Pubmed	A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-gamma gene cluster.	PCDHGA4 PCDHGA3 PCDHGA12	2.64e-04	44	98	3	19029045
Pubmed	P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons.	RPS6KA2 MAPK3	2.79e-04	9	98	2	19555761
Cytoband	5q31	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHB18P PCDHGA12	7.59e-14	115	98	10	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHB18P PCDHGA12	9.67e-10	298	98	10	chr5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr11q13	WNT11 ACTN3 DPF2 ARHGEF17 LTO1 THAP12	4.42e-04	454	98	6	chr11q13
Cytoband	11q13.5	WNT11 THAP12	9.22e-04	21	98	2	11q13.5
Cytoband	10p12.1	PDSS1 GPR158	2.15e-03	32	98	2	10p12.1
GeneFamily	Clustered protocadherins	PCDHGB6 PCDHGA4 PCDHGA3 PCDHB5 PCDHB13 PCDHB8 PCDHB3 PCDHB16 PCDHB18P PCDHGA12	3.67e-14	64	68	10	20
GeneFamily	Actinins	ACTN4 ACTN3	8.32e-05	4	68	2	1112
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	SH3TC2 ODAD4 TTC1 IFIT2	9.25e-04	115	68	4	769
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	NET1 ARHGEF5 ARHGEF17	1.97e-03	66	68	3	722
Coexpression	LEE_BMP2_TARGETS_DN	PDSS1 MCM4 E2F3 MOAP1 CDC45 CACTIN SERPINB9 STRAP NAT10 GSTCD PRMT3 ADI1 NME1 CTPS1	6.75e-06	904	98	14	M2325
Coexpression	LEE_BMP2_TARGETS_DN	PDSS1 MCM4 E2F3 MOAP1 CDC45 CACTIN SERPINB9 STRAP NAT10 GSTCD PRMT3 ADI1 NME1 CTPS1	8.44e-06	922	98	14	MM1068
Coexpression	GSE7460_CTRL_VS_TGFB_TREATED_ACT_TCONV_UP	PCDHB13 PRXL2A MIA2 CNGA1 HSDL1 TOP3A CYB5R1	1.01e-05	199	98	7	M5694
Coexpression	BERENJENO_TRANSFORMED_BY_RHOA_UP	NET1 MCM4 ACTN4 IFIT2 CDC7 CDC45 IVNS1ABP CSNK2A2 NME1 CTPS1	4.09e-05	550	98	10	M16189
Coexpression	GSE6259_FLT3L_INDUCED_33D1_POS_DC_VS_CD4_TCELL_DN	NET1 MCM4 DNTTIP1 TBC1D8 GSTCD CTPS1	4.38e-05	170	98	6	M6747
Coexpression	BERENJENO_TRANSFORMED_BY_RHOA_UP	NET1 MCM4 ACTN4 IFIT2 CDC7 CDC45 IVNS1ABP CSNK2A2 NME1 CTPS1	5.59e-05	571	98	10	MM1100
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	NCOA2 MYCBP2 KDM4C RPS6KA2 E2F3 ARHGAP35 PIK3R4 MIA2 SYNJ2 PRRC2C PRMT3 ZMYM4	8.43e-05	856	98	12	M4500
Coexpression	GSE21927_SPLENIC_C26GM_TUMOROUS_VS_4T1_TUMOR_MONOCYTES_DN	NET1 BCOR HTATSF1 LONRF3 CAPRIN1 THAP12	9.63e-05	196	98	6	M7590
Coexpression	GAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_10DY_UP	MCM4 ADA IFIT2 APOL3 NCOA7 NME1	9.63e-05	196	98	6	M41141
Coexpression	GSE28726_NAIVE_VS_ACTIVATED_CD4_TCELL_DN	MCM4 ACTN4 PFKM CDC45 NME1 CTPS1	1.05e-04	199	98	6	M8314
Coexpression	GSE22886_UNSTIM_VS_IL2_STIM_NKCELL_DN	PDSS1 MCM4 CDC45 PRMT3 NME1 CTPS1	1.08e-04	200	98	6	M4531
Coexpression	GSE36078_UNTREATED_VS_AD5_INF_IL1R_KO_MOUSE_LUNG_DC_DN	RMDN2 PCDHB16 TGM2 NAT10 THAP12 ALOX15	1.08e-04	200	98	6	M9296
Coexpression	GSE40666_NAIVE_VS_EFFECTOR_CD8_TCELL_WITH_IFNA_STIM_90MIN_DN	ADGRL1 E2F3 PFKM NCOA7 CTPS1 ZMYM4	1.08e-04	200	98	6	M9211
Coexpression	GSE10239_MEMORY_VS_DAY4.5_EFF_CD8_TCELL_DN	MCM4 E2F3 CDC7 STRAP CSNK2A2 CTPS1	1.08e-04	200	98	6	M3074
Coexpression	MANALO_HYPOXIA_DN	PDSS1 MCM4 CDC7 NAT10 NME1 CTPS1 TOP3A	1.15e-04	292	98	7	M18562
Coexpression	ZENG_GU_ICB_CONTROL_METAGENE_42_PRECICTIVE_ICB_RESISTANCE	XPA DPF2 MOAP1 TATDN3 LTO1 ADI1	1.20e-04	204	98	6	MM17085
Coexpression	PUJANA_CHEK2_PCC_NETWORK	WNT11 MCM4 ADA CDC7 CDC45 PRRC2C SYK PRMT3 NME1 CTPS1 THAP12	1.30e-04	761	98	11	M11961
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_UP	NCOA2 NET1 PDSS1 TTC1 IFIT2 IVNS1ABP SERPINB9 STRAP HTATSF1	1.53e-04	523	98	9	M12707
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_UP	NCOA2 NET1 PDSS1 TTC1 IFIT2 IVNS1ABP SERPINB9 STRAP HTATSF1	1.78e-04	534	98	9	MM1054
Coexpression	ONKEN_UVEAL_MELANOMA_UP	NCOA2 RPS6KA2 ADGRL1 MCM4 ACTN4 BCOR PRRC2C NAT10 DIAPH2 ADI1 CTPS1	1.80e-04	790	98	11	M12490
Computational	Nucleotide (purine) biosynthesis.	ADA NME1 CTPS1	1.50e-04	19	60	3	MODULE_102
Computational	Genes in the cancer module 57.	MCM4 E2F3 CDC7 CDC45	2.59e-04	56	60	4	MODULE_57
Computational	Genes in the cancer module 219.	ADA NME1 CTPS1	4.40e-04	27	60	3	MODULE_219
Drug	Alfuzosin hydrochloride [81403-68-1]; Down 200; 9.4uM; MCF7; HT_HG-U133A	RARG RPS6KA2 ADGRL1 ARHGAP35 TGM2 CACTIN MIA2 TOP3A	2.29e-06	198	98	8	5242_DN
Disease	mental development measurement	PCDHGB6 PCDHGA4 PCDHGA3	6.42e-05	25	92	3	EFO_0008230
Disease	childhood trauma measurement, alcohol consumption measurement	PCDHGB6 PCDHGA4 PCDHGA3 PCDHGA12	7.33e-05	71	92	4	EFO_0007878, EFO_0007979
Disease	focal segmental glomerulosclerosis 1 (implicated_via_orthology)	ACTN4 ACTN3	9.56e-05	5	92	2	DOID:0111128 (implicated_via_orthology)
Disease	Pancreatic Ductal Adenocarcinoma	ADA ABLIM2	5.19e-04	11	92	2	C1335302
Disease	temporal pole volume measurement	DNTTIP1 GPR158	6.22e-04	12	92	2	EFO_0010334
Disease	age at onset, smoking initiation	NCOA2 MYCBP2	1.59e-03	19	92	2	EFO_0004847, EFO_0005670
Disease	colorectal carcinoma (is_implicated_in)	NCOA2 STRAP	2.13e-03	22	92	2	DOID:0080199 (is_implicated_in)
Disease	progranulin measurement	NCOA2 ADGRL1	2.13e-03	22	92	2	EFO_0004625
Disease	Sarcosine measurement	PCDHGA4 PCDHGA3	2.33e-03	23	92	2	EFO_0021668

Protein segments in the cluster

Peptide	Gene	Start	Entry
PEDEKRELLDLLYKA	ADA	336	P00813
LEDLDRYNKARKDPD	CFAP61	491	Q8NHU2
QLYELDADPKRKEFL	ARID3C	106	A6NKF2
AEIELLYKALEEPLL	ADGRL1	1331	O94910
YKPRENDELALEKAD	ARHGEF5	1521	Q12774
RPELIEYDKLRKDDP	ACTN4	206	O43707
KKEIDPLELDFLLRF	DNAH11	3796	Q96DT5
EILDYRDLAALPKSK	ABLIM2	306	Q6H8Q1
EKYRDILKFPEELEH	DIAPH2	886	O60879
DKLVYVDLLREEPDA	BCOR	801	Q6W2J9
EELSLLDEFYKLVDP	CAPRIN1	181	Q14444
YPELVLDKALDREER	PCDHB5	191	Q9Y5E4
DKLQEPLLEALRLYA	RARG	351	P13631
YPELVLKRALDREEK	PCDHGA12	191	O60330
YPELSLEKLLDREEQ	PCDHGB6	191	Q9Y5F9
LKLRDSDEGRKYPEL	PCDHB18P	126	Q96TA0
KYPELVLDQSLDREK	PCDHB18P	136	Q96TA0
IDKLEYLDEKQRDPR	NET1	366	Q7Z628
YELLVKDLLKHTPED	ARHGEF17	1216	Q96PE2
KYPELVLERALDREE	PCDHGA4	221	Q9Y5G9
VELLKELSRKPDIYE	MCM4	446	P33991
KYPELVLDKALDREE	PCDHB13	191	Q9Y5F0
LGLKPEKLEKDLDRY	LPCAT1	341	Q8NF37
EEEEFLKLPRLKLEV	IVNS1ABP	166	Q9Y6Y0
PEDIRDELKKLYAQL	GPR158	711	Q5T848
EEIRPKEVYLDRKLL	SYK	356	P43405
LELYGELEELPEDKR	CCDC28A	221	Q8IWP9
DEEKLSAYVLRLEPL	MOAP1	261	Q96BY2
DFEKDKYDIRIPEDL	MORC3	211	Q14149
VLKEPKYQEELEDRL	MSTO1	201	Q9BUK6
RPILKILAKYEIDLD	PFKM	746	P08237
EDIYTLDEELPKRVK	KDM4C	981	Q9H3R0
KLYDLPVDERFLEDK	ALOX15	156	P16050
VDKLLKGYDIRLRPD	GABRB3	41	P28472
ELDDLPKERLKELIF	MAPK3	351	P27361
EELEALFLPYDLKRL	NAT10	811	Q9H0A0
DILPLTLEEKENKEY	THAP12	151	O43422
KLLSLLPDEEKDEVY	PASD1	76	Q8IV76
LALKLLDEDEIRGYK	HTATSF1	196	O43719
YPELVLERALDREKK	PCDHGA3	191	Q9Y5H0
RDGRKYPELVLDKEL	PCDHB16	186	Q9NRJ7
KLLIKQDDDLEVPAY	CDC45	116	O75419
DLFDAYDLEKLPLVE	E2F3	446	O00716
KVKLDDLLAYLPSDD	COG1	526	Q8WTW3
EKEEYLKPVLEDDLL	PRMT3	116	O60678
NEVPDEAYDLLDKLL	CDC7	536	O00311
RDLKGLYEDIRKELL	PDSS1	101	Q5T2R2
PRDEADALYEALKKL	APOL3	116	O95236
PEALDLLDKLLRYDH	CSNK2A2	296	P19784
LEEKLYKDPRLGELQ	DRC7	856	Q8IY82
FYRRKDEPDKAIELL	IFIT2	256	P09913
DPTYDKLHEDLDKIR	LTO1	96	Q8WV07
KPIDLLAKYISAEDD	CACTIN	306	Q8WUQ7
EIYLPIREALKDKDV	HSDL1	131	Q3SXM5
SYEADPLKKELLELL	GSTCD	116	Q8NEC7
ALPAEDLLLYLKRLE	CNTROB	821	Q8N137
RDGRKYPELVLDKAL	PCDHB3	186	Q9Y5E6
KYPELVLDKALDREE	PCDHB8	191	Q9UN66
LKFELLEKDPYALDV	MIA2	1101	Q96PC5
SPKDLARYLQELDKD	FUT5	311	Q11128
LELVLRKYKELDIEP	UVSSA	371	Q2YD98
KDLDVALPIIENYKD	TATDN3	86	Q17R31
PTYKDDADLVELKRE	SYNJ2	1066	O15056
LADPEAEKERIRIYK	LIAT1	176	Q6ZQX7
PLELLKDEGLQYLER	LRRC28	31	Q86X40
DLLKEHYVDLKDRPF	NME1	46	P15531
EYDKLPDADLARKAL	NCOA7	186	Q8NI08
DLEIAKEYDLPDAKS	ODAD4	346	Q96NG3
RLLEKPYVRDDDKAK	PRRC2C	1316	Q9Y520
ELYPALKLEAELDTE	SPATA32	76	Q96LK8
KLEIKYIDSADLEPI	CTPS1	331	P17812
AEKDLDEAYLKRRPL	SHISA7	326	A6NL88
LKEAIPKLEEYIQDE	RMDN2	96	Q96LZ7
KSEEPLLALKLYEEA	SH3TC2	1076	Q8TF17
VLKDLLDPIKELYED	MYCBP2	4486	O75592
LDPIKELYEDVRRKA	MYCBP2	4491	O75592
LDPNEKYLLRLLDKT	CYB5R1	41	Q9UHQ9
ELFYELELDAKPSKE	ARHGAP35	501	Q9NRY4
PQKAALEYLEDIDLK	PRXL2A	41	Q9BRX8
DKLLRIYDLNKPEAE	STRAP	121	Q9Y3F4
RPDLIDYAKLRKDDP	ACTN3	201	Q08043
EKEVLKYLPDKLRAE	CNGA1	446	P29973
RYLLDKDDTKDIGLP	NCOA2	746	Q15596
REPDKRLEAEDYLKQ	PIK3R4	296	Q99570
LLAERDLYLENPEIK	TGM2	576	P21980
KKDYPALLSLDENEL	MTRFR	46	Q9H3J6
YARKELSLLVLLPDD	SERPINB9	221	P50453
DDYRGCLDLKLEELK	DNTTIP1	281	Q9H147
SILPEDLEELYDLFK	TBC1D8	811	O95759
KLDASILEDRDKPYA	DPF2	196	Q92785
READEVKPLDELYEK	SCN8A	1026	Q9UQD0
KPDLRAELEADLKLI	TOP3A	581	Q13472
PDILKAYEDDVLLID	TOPAZ1	851	Q8N9V7
QEYLLKDCDLEKREP	XPA	146	P23025
KDLDIRPVKDSELVY	WNT11	261	O96014
DEALEDYKSILEKDP	TTC1	206	Q99614
NIRIKEEPLDDEYDK	ZMYM4	246	Q5VZL5
LDADKYENDPELEKI	ADI1	41	Q9BV57
IYRDLKPENILLDEE	RPS6KA2	181	Q15349
LPEELKERRKLYEEE	LONRF3	531	Q496Y0