Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR7G1 OR4K2 OR2T33 OR7D2 OR52E4 OR13G1 OR2T12 OR13C7 OR13C6P	2.99e-05	431	74	9	GO:0004984
GeneOntologyMolecularFunction	dynein light intermediate chain binding	HOOK3 DNAH10 DNAH1	1.50e-04	28	74	3	GO:0051959
GeneOntologyMolecularFunction	dynein intermediate chain binding	HOOK3 DNAH10 DNAH1	3.47e-04	37	74	3	GO:0045505
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR7G1 PDE1C OR4K2 OR2T33 OR7D2 OR52E4 OR13G1 OR2T12 OR13C7 OR13C6P ITPR3	3.32e-06	547	73	11	GO:0007606
GeneOntologyBiologicalProcess	sensory perception of smell	OR7G1 PDE1C OR4K2 OR2T33 OR7D2 OR52E4 OR13G1 OR2T12 OR13C7 OR13C6P	5.37e-06	465	73	10	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR7G1 OR4K2 OR2T33 OR7D2 OR52E4 OR13G1 OR2T12 TLR6 OR13C7 OR13C6P	1.52e-05	524	73	10	GO:0009593
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR7G1 OR4K2 OR2T33 OR7D2 OR52E4 OR13G1 OR2T12 OR13C7 OR13C6P	2.12e-05	432	73	9	GO:0050911
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR7G1 OR4K2 OR2T33 OR7D2 OR52E4 OR13G1 OR2T12 OR13C7 OR13C6P	5.21e-05	485	73	9	GO:0050907
GeneOntologyBiologicalProcess	macroautophagy	ADCY10 IRGM PLAA LRRK2 WDFY3 LRBA RB1CC1 EPG5	5.22e-05	374	73	8	GO:0016236
GeneOntologyBiologicalProcess	vacuolar transport	IRGM HOOK3 LRRK2 VPS13A DENND3 EPG5	5.27e-05	187	73	6	GO:0007034
GeneOntologyBiologicalProcess	sensory perception	OR7G1 PDE1C OR4K2 LCTL OR2T33 OR7D2 OR52E4 ZFHX2 OR13G1 OR2T12 OR13C7 OR13C6P ITPR3	8.84e-05	1072	73	13	GO:0007600
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	ADCY10 OR7G1 PDE4B OR4K2 OR2T33 OR7D2 LRRK2 TENM1 OR52E4 ARHGEF12 OR13G1 OR2T12 OR13C7 OR13C6P ITPR3	9.20e-05	1395	73	15	GO:0007186
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR7G1 OR4K2 OR2T33 OR7D2 OR52E4 OR13G1 OR2T12 OR13C7 OR13C6P	2.07e-04	582	73	9	GO:0050906
GeneOntologyBiologicalProcess	detection of stimulus	OR7G1 OR4K2 OR2T33 OR7D2 OR52E4 OR13G1 OR2T12 TLR6 OR13C7 OR13C6P	2.20e-04	722	73	10	GO:0051606
Domain	ARM-type_fold	IPO5 PDS5B PLAA LRRK2 ZNFX1 WDFY3 LRBA ARMH3	4.27e-05	339	71	8	IPR016024
Domain	WD40_repeat_dom	PLAA WDR87 LRRK2 WDFY3 LRBA DENND3 SON	1.33e-04	297	71	7	IPR017986
Domain	DUF4704	WDFY3 LRBA	1.41e-04	5	71	2	IPR031570
Domain	DUF4704	WDFY3 LRBA	1.41e-04	5	71	2	PF15787
Domain	PH_BEACH	WDFY3 LRBA	2.12e-04	6	71	2	PF14844
Domain	-	PLAA WDR87 LRRK2 WDFY3 LRBA DENND3 SON	2.69e-04	333	71	7	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	PLAA WDR87 LRRK2 WDFY3 LRBA DENND3 SON	2.79e-04	335	71	7	IPR015943
Domain	PH-BEACH_dom	WDFY3 LRBA	3.93e-04	8	71	2	IPR023362
Domain	-	WDFY3 LRBA	3.93e-04	8	71	2	2.30.29.40
Domain	PH_BEACH	WDFY3 LRBA	3.93e-04	8	71	2	PS51783
Domain	BEACH_dom	WDFY3 LRBA	5.04e-04	9	71	2	IPR000409
Domain	BEACH	WDFY3 LRBA	5.04e-04	9	71	2	PS50197
Domain	Beach	WDFY3 LRBA	5.04e-04	9	71	2	PF02138
Domain	-	WDFY3 LRBA	5.04e-04	9	71	2	1.10.1540.10
Domain	Beach	WDFY3 LRBA	5.04e-04	9	71	2	SM01026
Domain	WD40	PLAA WDR87 LRRK2 WDFY3 LRBA DENND3	5.42e-04	268	71	6	SM00320
Domain	ARM-like	IPO5 PDS5B PLAA LRRK2 WDFY3 LRBA	5.63e-04	270	71	6	IPR011989
Domain	WD40_repeat	PLAA WDR87 LRRK2 WDFY3 LRBA DENND3	5.85e-04	272	71	6	IPR001680
Domain	Olfact_rcpt	OR7G1 OR4K2 OR2T33 OR7D2 OR52E4 OR13G1 OR2T12	7.24e-04	393	71	7	IPR000725
Domain	Dynein_heavy_chain_D4_dom	DNAH10 DNAH1	1.26e-03	14	71	2	IPR024317
Domain	Dynein_HC_stalk	DNAH10 DNAH1	1.26e-03	14	71	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH10 DNAH1	1.26e-03	14	71	2	IPR013602
Domain	DHC_N2	DNAH10 DNAH1	1.26e-03	14	71	2	PF08393
Domain	MT	DNAH10 DNAH1	1.26e-03	14	71	2	PF12777
Domain	AAA_8	DNAH10 DNAH1	1.26e-03	14	71	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH10 DNAH1	1.26e-03	14	71	2	IPR011704
Domain	AAA_5	DNAH10 DNAH1	1.26e-03	14	71	2	PF07728
Domain	DHC_fam	DNAH10 DNAH1	1.45e-03	15	71	2	IPR026983
Domain	Dynein_heavy_dom	DNAH10 DNAH1	1.45e-03	15	71	2	IPR004273
Domain	Dynein_heavy	DNAH10 DNAH1	1.45e-03	15	71	2	PF03028
Domain	-	IPO5 PDS5B LRRK2 WDFY3 LRBA	1.56e-03	222	71	5	1.25.10.10
Domain	PDEase	PDE1C PDE4B	2.34e-03	19	71	2	IPR023088
Domain	PDEase_I	PDE1C PDE4B	2.86e-03	21	71	2	PF00233
Domain	-	PMS1 GALK2	2.86e-03	21	71	2	3.30.230.10
Domain	PDEASE_I	PDE1C PDE4B	2.86e-03	21	71	2	PS00126
Domain	PDEase_CS	PDE1C PDE4B	2.86e-03	21	71	2	IPR023174
Domain	TIR	TLR7 TLR6	2.86e-03	21	71	2	SM00255
Domain	WD40	PLAA WDR87 WDFY3 LRBA DENND3	3.05e-03	259	71	5	PF00400
Domain	Ribosomal_S5_D2-typ_fold_subgr	PMS1 GALK2	3.13e-03	22	71	2	IPR014721
Domain	TIR	TLR7 TLR6	3.13e-03	22	71	2	PF01582
Domain	-	PDE1C PDE4B	3.13e-03	22	71	2	1.10.1300.10
Domain	PDEase_catalytic_dom	PDE1C PDE4B	3.42e-03	23	71	2	IPR002073
Domain	-	TLR7 TLR6	3.42e-03	23	71	2	3.40.50.10140
Domain	HDc	PDE1C PDE4B	3.73e-03	24	71	2	SM00471
Domain	HD/PDEase_dom	PDE1C PDE4B	3.73e-03	24	71	2	IPR003607
Domain	TIR	TLR7 TLR6	3.73e-03	24	71	2	PS50104
Domain	TIR_dom	TLR7 TLR6	4.04e-03	25	71	2	IPR000157
Domain	WD_REPEATS_1	PLAA WDR87 WDFY3 LRBA DENND3	4.12e-03	278	71	5	PS00678
Domain	WD_REPEATS_2	PLAA WDR87 WDFY3 LRBA DENND3	4.19e-03	279	71	5	PS50082
Domain	WD_REPEATS_REGION	PLAA WDR87 WDFY3 LRBA DENND3	4.19e-03	279	71	5	PS50294
Domain	LRRCT	TLR7 TLR6	6.57e-03	32	71	2	PF01463
Domain	Ribosomal_S5_D2-typ_fold	PMS1 GALK2	7.39e-03	34	71	2	IPR020568
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR7G1 PDE1C OR4K2 OR2T33 OR7D2 OR52E4 OR13G1 OR2T12	7.05e-05	389	51	8	M14091
Pubmed	Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.	OR4K2 OR7D2 OR13G1 OR2T12	3.04e-06	46	75	4	32126975
Pubmed	Toll receptors instruct axon and dendrite targeting and participate in synaptic partner matching in a Drosophila olfactory circuit.	TLR7 TLR6	4.59e-06	2	75	2	25741726
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ARHGAP32 PDE4B HOOK3 KDM5A PRRC2C HECTD4 ARHGEF12 SPATA20 ZNFX1 WDFY3 CAMSAP2	6.74e-06	963	75	11	28671696
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR7G1 OR4K2 OR2T33 OR52E4 OR13G1 OR2T12 OR13C7	9.01e-06	340	75	7	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR7G1 OR4K2 OR2T33 OR52E4 OR13G1 OR2T12 OR13C7	9.01e-06	340	75	7	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR7G1 OR4K2 OR2T33 OR52E4 OR13G1 OR2T12 OR13C7	9.53e-06	343	75	7	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR7G1 OR4K2 OR2T33 OR52E4 OR13G1 OR2T12 OR13C7	1.01e-05	346	75	7	14611657
Pubmed	Upregulation of Toll-like receptors (TLRs) 6, 7, and 8 in keloid scars.	TLR7 TLR6	1.37e-05	3	75	2	21677671
Pubmed	Gene Polymorphism of Toll-Like Receptors and Lung Function at Five to Seven Years of Age after Infant Bronchiolitis.	TLR7 TLR6	1.37e-05	3	75	2	26741133
Pubmed	Chorein, the protein responsible for chorea-acanthocytosis, interacts with β-adducin and β-actin.	VPS13A ADD2	1.37e-05	3	75	2	24129186
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	ARHGAP32 CNOT11 ARHGEF12 CAMSAP2 ADD2 NIN	1.77e-05	251	75	6	29778605
Pubmed	H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1.	KDM5A STAT4	2.75e-05	4	75	2	27050510
Pubmed	Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides.	TLR7 TLR6	2.75e-05	4	75	2	11970999
Pubmed	Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion.	TLR7 TLR6	4.57e-05	5	75	2	24014382
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	PDS5B VPS13A DIP2C WDFY3	7.22e-05	102	75	4	10231032
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	PRRC2C ZFHX2 CAMSAP2 SON	7.79e-05	104	75	4	10470851
Pubmed	Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response.	TLR7 TLR6	1.27e-04	8	75	2	20100933
Pubmed	CFAP43 modulates ciliary beating in mouse and Xenopus.	AKAP3 DNAH1	1.27e-04	8	75	2	31884020
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	IPO5 ARHGAP32 HECTD4 RB1CC1 EPHA7 NIN	1.36e-04	363	75	6	14691545
Pubmed	Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors.	TLR7 TLR6	1.64e-04	9	75	2	24091496
Pubmed	Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming.	TLR7 TLR6	1.64e-04	9	75	2	34559989
Pubmed	The role of Eya1 and Eya2 in the taste system of mice from embryonic stage to adulthood.	POU2F3 ITPR3	1.64e-04	9	75	2	37181748
Pubmed	The human olfactory receptor gene family.	OR7G1 OR4K2 OR2T33 OR7D2 OR52E4 OR13G1 OR2T12	1.69e-04	541	75	7	14983052
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	ARHGAP32 UFSP2 VPS13A TENM1 ZFHX2 ARMH3 DENND3	1.91e-04	552	75	7	10737800
Pubmed	[Expression of toll-like receptors in human epidermal keratinocytes].	TLR7 TLR6	2.04e-04	10	75	2	18686608
Pubmed	Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis.	RB1CC1 EPG5	2.04e-04	10	75	2	26764600
Pubmed	Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation.	TLR7 TLR6	2.04e-04	10	75	2	20227302
Pubmed	Toll-like receptors.	TLR7 TLR6	2.04e-04	10	75	2	11782555
Pubmed	A family of human receptors structurally related to Drosophila Toll.	TLR7 TLR6	2.04e-04	10	75	2	9435236
Pubmed	Evidence for a gender-specific protective role of innate immune receptors in a model of perinatal brain injury.	TLR7 TLR6	2.49e-04	11	75	2	23843525
Pubmed	Identification of a key pathway required for the sterile inflammatory response triggered by dying cells.	TLR7 TLR6	2.49e-04	11	75	2	17572686
Pubmed	Toll-like receptors.	TLR7 TLR6	2.49e-04	11	75	2	18394314
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PDS5B PRRC2C ARHGEF12 CAMSAP2 SON EPG5	2.52e-04	407	75	6	12693553
Pubmed	Organization and evolutionary relatedness of OR37 olfactory receptor genes in mouse and human.	OR13C7 OR13C6P	2.99e-04	12	75	2	12906860
Pubmed	Pathogen recognition in the innate immune response.	TLR7 TLR6	2.99e-04	12	75	2	19382893
Pubmed	Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides.	POU2F3 ITPR3	2.99e-04	12	75	2	32294408
Pubmed	TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.	TLR7 TLR6	2.99e-04	12	75	2	26831104
Pubmed	Murine cerebral malaria development is independent of toll-like receptor signaling.	TLR7 TLR6	2.99e-04	12	75	2	17456769
Pubmed	The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling.	TLR7 TLR6	2.99e-04	12	75	2	20495560
Pubmed	EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.	VPS13A WDFY3 RB1CC1 EPG5	3.18e-04	150	75	4	32423001
Pubmed	Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling.	TLR7 TLR6	4.11e-04	14	75	2	14625308
Pubmed	YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes.	TLR7 TLR6	4.11e-04	14	75	2	34206257
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH10 DNAH1	4.11e-04	14	75	2	9373155
Pubmed	MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals.	TLR7 TLR6	4.11e-04	14	75	2	16886064
Pubmed	Inhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytes.	PDE1C PDE4B	4.11e-04	14	75	2	25852085
Pubmed	Polymorphisms of innate pattern recognition receptors, response to interferon-beta and development of neutralizing antibodies in multiple sclerosis patients.	TLR7 TLR6	4.11e-04	14	75	2	20595247
Pubmed	Mast cells as sensors of cell injury through IL-33 recognition.	TLR7 TLR6	4.11e-04	14	75	2	21239713
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	TLCD1 HOOK3 PTPRA VPS13A PEX13 WDFY3 LRBA RB1CC1 CAMSAP2	4.57e-04	1061	75	9	33845483
Pubmed	Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium.	POU2F3 ITPR3	4.73e-04	15	75	2	24428937
Pubmed	Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth.	IPO5 PLAA ARHGEF12 ARMH3	5.11e-04	170	75	4	36470425
Pubmed	Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice.	SPATA20 WDFY3	5.40e-04	16	75	2	16096065
Pubmed	Expression of Toll-like receptors in the developing brain.	TLR7 TLR6	5.40e-04	16	75	2	22666391
Pubmed	Natural selection in the TLR-related genes in the course of primate evolution.	TLR7 TLR6	5.40e-04	16	75	2	18810425
Pubmed	A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling.	TLR7 TLR6	5.40e-04	16	75	2	16024789
Pubmed	Binding specificity of Toll-like receptor cytoplasmic domains.	TLR7 TLR6	7.66e-04	19	75	2	16482509
Pubmed	Toll-like receptor signaling pathway variants and prostate cancer mortality.	TLR7 TLR6	7.66e-04	19	75	2	19505919
Pubmed	Hydroxypropyl-β-cyclodextrin spikes local inflammation that induces Th2 cell and T follicular helper cell responses to the coadministered antigen.	TLR7 TLR6	7.66e-04	19	75	2	25681338
Pubmed	Genome-wide association study reveals genetic risk underlying Parkinson's disease.	MMRN1 LRRK2	8.50e-04	20	75	2	19915575
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	IPO5 PRRC2C ZNFX1 ITPR3	9.73e-04	202	75	4	33005030
Pubmed	Toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors.	TLR7 TLR6	1.03e-03	22	75	2	31729371
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	CNOT11 PTPRA RB1CC1 SON EPHA7	1.08e-03	358	75	5	32460013
Pubmed	Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human.	PMS1 WDFY3	1.23e-03	24	75	2	17452356
Pubmed	Overview of PDEs and their regulation.	PDE1C PDE4B	1.33e-03	25	75	2	17307970
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	PTPRA TLR7 ITPR3	1.38e-03	101	75	3	23382219
Pubmed	TLR5 Supports Development of Placental Labyrinthine Zone in Mice.	TLR7 TLR6	1.44e-03	26	75	2	34395439
Pubmed	The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.	PDS5B HOOK3 PLAA RB1CC1	1.57e-03	230	75	4	35449600
Pubmed	Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.	ANGPT2 EPHA7	1.67e-03	28	75	2	24483146
Pubmed	Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.	IRGM LRRK2	1.67e-03	28	75	2	18587394
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PMS1 ARHGAP32 PTPRA VPS13A RB1CC1 ADD2 ITPR3 NIN	1.89e-03	1049	75	8	27880917
Pubmed	Phosphoproteomic analysis of the developing mouse brain.	PDS5B ARHGEF12 CAMSAP2 ADD2	2.00e-03	246	75	4	15345747
Pubmed	Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis.	IRGM LRRK2	2.05e-03	31	75	2	21072187
Interaction	OR2T12 interactions	OR2T33 OR2T12	1.19e-05	2	70	2	int:OR2T12
Cytoband	1q44	OR2T33 OR13G1 OR2T12	7.97e-04	110	75	3	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2T33 OR13G1 OR2T12	1.23e-03	128	75	3	chr1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q24	ADCY10 PRRC2C STYXL2	1.26e-03	129	75	3	chr1q24
Cytoband	12q23.3	TTC41P TCP11L2	1.51e-03	35	75	2	12q23.3
GeneFamily	Olfactory receptors, family 13	OR13G1 OR13C7 OR13C6P	3.39e-05	23	50	3	162
GeneFamily	WD repeat domain containing\|BEACH domain containing	WDFY3 LRBA	2.67e-04	9	50	2	1230
GeneFamily	CD molecules\|Toll like receptors	TLR7 TLR6	3.33e-04	10	50	2	948
GeneFamily	WD repeat domain containing	PLAA WDR87 WDFY3 LRBA DENND3	7.65e-04	262	50	5	362
GeneFamily	Dyneins, axonemal	DNAH10 DNAH1	9.93e-04	17	50	2	536
GeneFamily	Phosphodiesterases	PDE1C PDE4B	1.99e-03	24	50	2	681
Coexpression	GSE11961_UNSTIM_VS_ANTI_IGM_AND_CD40_STIM_6H_FOLLICULAR_BCELL_DN	ARHGAP32 ARHGEF12 RO60 PARVB TLR7 TLR6	2.04e-05	200	73	6	M9335
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	PMS1 PDS5B GALK2 PTPRA KDM5A PRRC2C VPS13A WDFY3 RB1CC1 CAMSAP2 SON	2.37e-05	856	73	11	M4500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_top-relative-expression-ranked_500	HOOK3 PRR5L PLAA TENM1 MKX PEX13 RO60 SON EPHA7	7.82e-06	429	67	9	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_k-means-cluster#4_top-relative-expression-ranked_500	HOOK3 PLAA TENM1 MKX PEX13 RO60 SON	1.27e-05	247	67	7	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_500_k4
CoexpressionAtlas	kidney_adult_Podocyte_MafB_top-relative-expression-ranked_1000	ARHGAP32 PDE4B LCTL TCP11L2 VPS13A ARHGEF12 TLR7 WDFY3 LRBA RB1CC1 ABCA9	5.77e-05	838	67	11	gudmap_kidney_adult_Podocyte_MafB_1000
CoexpressionAtlas	kidney_adult_Podocyte_MafB_top-relative-expression-ranked_500	ARHGAP32 PDE4B LCTL VPS13A ARHGEF12 TLR7 LRBA ABCA9	7.72e-05	445	67	8	gudmap_kidney_adult_Podocyte_MafB_500
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE1C DNAH10 TENM1 DNAH1 EPHA7	1.39e-05	184	74	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE1C DNAH10 TENM1 DNAH1 EPHA7	1.39e-05	184	74	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE1C DNAH10 TENM1 DNAH1 EPHA7	1.39e-05	184	74	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOOK3 PTPRA PRRC2C TLR7 ABCA9	1.75e-05	193	74	5	06b65110db974f4ef90d3511ff34428976a52c9c
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOOK3 PTPRA PRRC2C TLR7 ABCA9	1.75e-05	193	74	5	9c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCell	facs-Brain_Myeloid-Hippocampus-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOOK3 PTPRA PRRC2C TLR7 ABCA9	1.75e-05	193	74	5	a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	TCP11L2 KDM5A PRRC2C LRBA RB1CC1	1.75e-05	193	74	5	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOOK3 PTPRA PRRC2C TLR7 ABCA9	1.75e-05	193	74	5	b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-skeletal_muscle_satellite_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IPO5 PDE1C PDE4B TCP11L2 PRRC2C	1.93e-05	197	74	5	5bc11aff92da2a0aca8473f997fe7a99f3cae75d
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PRRC2C VPS13A TENM1 LRBA STAT4	1.93e-05	197	74	5	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PRRC2C VPS13A TENM1 LRBA STAT4	2.02e-05	199	74	5	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	LPS_IL1RA\|World / Treatment groups by lineage, cell group, cell type	ANGPT2 PRRC2C ARHGEF12 ZNFX1 PARVB	2.07e-05	200	74	5	a02fa5b3c4723a6eaa3c685588666c710478dd25
Drug	Nifenazone [2139-47-1]; Down 200; 13uM; PC3; HT_HG-U133A	GALK2 KDM5A ARHGEF12 DIP2C WDFY3 TMEM231 ARMH3	2.79e-06	195	72	7	2122_DN
Disease	polymyositis (is_implicated_in)	PMS1 STAT4	1.61e-05	3	69	2	DOID:0080745 (is_implicated_in)
Disease	dermatomyositis (is_implicated_in)	PMS1 STAT4	1.61e-05	3	69	2	DOID:10223 (is_implicated_in)
Disease	autism spectrum disorder (implicated_via_orthology)	ARHGAP32 KDM5A WDFY3 LRBA ITPR3	2.93e-05	152	69	5	DOID:0060041 (implicated_via_orthology)
Disease	interleukin 25 measurement	ARHGEF12 POU2F3	1.92e-04	9	69	2	EFO_0008182
Disease	anti-centromere-antibody-positive systemic scleroderma	PARVB STAT4	1.92e-04	9	69	2	EFO_0008536
Disease	intracerebral hemorrhage	OR52E4 PARVB	6.33e-04	16	69	2	EFO_0005669
Disease	low density lipoprotein cholesterol measurement, body fat percentage	DNAH10 UGT1A5	7.16e-04	17	69	2	EFO_0004611, EFO_0007800
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR7 TLR6	7.16e-04	17	69	2	DOID:8677 (biomarker_via_orthology)
Disease	parental longevity	PDE4B TCP11L2 VPS13A HECTD4 PARVB EPHA7	1.05e-03	494	69	6	EFO_0007796
Disease	Colorectal Carcinoma	VPS13A TENM1 DIP2C AKAP3 CAMSAP2 ABCA9 EPHA7	1.26e-03	702	69	7	C0009402
Disease	obesity (implicated_via_orthology)	DNAH10 ZFHX2 STAT4 ITPR3	1.64e-03	215	69	4	DOID:9970 (implicated_via_orthology)
Disease	tuberculosis (is_implicated_in)	IRGM TLR6	1.96e-03	28	69	2	DOID:399 (is_implicated_in)
Disease	IgA glomerulonephritis (is_implicated_in)	ADD2 STAT4	2.25e-03	30	69	2	DOID:2986 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
TRHMALSSLFMEVLM	EPG5	2261	Q9HCE0
LSPMATMAAVQMQHM	CELF3	226	Q5SZQ8
RDHLQTMMESVIMTI	CENPQ	81	Q7L2Z9
TMMESVIMTILSNSI	CENPQ	86	Q7L2Z9
HSVMEQLMSVTGVHM	ABCA9	196	Q8IUA7
LMETVNNLLTMMSTS	ANGPT2	251	O15123
AVLDLMVEFIVTHMM	ARMH3	446	Q5T2E6
AHLAVMMQMNTALET	ADCY10	1231	Q96PN6
SIMVMKMNGSLHQEL	DENND3	1051	A2RUS2
LIDMLTETMARMHLL	CBY3	186	A6NI87
SNILVMDHMIMTPEM	ARHGEF12	1351	Q9NZN5
QKVHMHMVDLMSSII	PDS5B	171	Q9NTI5
GHMMSTMVLSRKQSV	ITPR3	921	Q14573
SMMSVQENIHMLSEE	RB1CC1	1441	Q8TDY2
IHMFTGMETVLLVVM	OR52E4	106	Q8NGH9
LILMTVSNSHLHMPM	OR13C6P	46	Q8NH95
LILMTVSNSHLHMPM	OR13C7	46	P0DN81
TIMNHHMCVALLSMV	OR13G1	131	Q8NGZ3
HMCVALLSMVMAIAV	OR13G1	136	Q8NGZ3
LSQLSLMDMMLVSTT	OR2T12	61	Q8NG77
QSLMMLQMFEDLHIQ	MMRN1	556	Q13201
IMVASAQFSMNHVML	IRGM	116	A1A4Y4
LRHVMATNTTMMGKT	MKX	231	Q8IYA7
MLAAEPLLSHMQMVT	LCTL	526	Q6UWM7
MGVMHSMSQVIFALT	OR4K2	151	Q8NGD2
TLVIEMVMATDMSCH	PDE1C	331	Q14123
IDMVLATDMSKHMSL	PDE4B	511	Q07343
MVQLLGELMNQSHMS	GALK2	356	Q01415
NTIHLISQVMDNMVM	LRBA	1356	P50851
VMLSMLMHSSSKEVF	LRRK2	401	Q5S007
VLLMLFHTMAQIMAE	LAMP5	16	Q9UJQ1
LSQLSLMDMMLVSTT	OR2T33	61	Q8NG76
MHPNLQTLIMADALM	HECTD4	551	Q9Y4D8
MMEESVQHVVMTAIQ	HOOK3	141	Q86VS8
SELLMIIQMETQSSM	IPO5	91	O00410
TRMMESKMIAAIHSS	ARHGAP32	1416	A7KAX9
KIMSSIQTMRAQMLH	EPHA7	976	Q15375
MVNLESMHTDIKMSG	POU2F3	1	Q9UKI9
MHSLRAANLAKMTMV	KDM5A	1141	P29375
HISEELTTTTEMMMG	PARVB	221	Q9HBI1
HSDIQLLAMATMMHS	PRR5L	296	Q6MZQ0
MSTMDALVQSLMVLQ	OR7G1	151	Q8NGA0
VPTMDTVQMSHLLDM	DNAH1	2201	Q9P2D7
ILHVDEMMMHVQQLS	DBF4B	181	Q8NFT6
EMMMHVQQLSLASLC	DBF4B	186	Q8NFT6
GILTSVMNMMHVISI	DIP2C	551	Q9Y2E4
VVQMFETMLTRHTTM	DNAH10	2096	Q8IVF4
HKMALMSVLGTAVMN	PMS1	206	P54277
IQMSAHLAMIDTLMM	CAMSAP2	131	Q08AD1
HLAMIDTLMMAYTVE	CAMSAP2	136	Q08AD1
TFVVIDAMLDMMHTE	PTPRA	451	P18433
HVLDLMQMDMANFTI	TCP11L2	216	Q8N4U5
LKAMMHDLQITCSEM	NIN	1491	Q8N4C6
HSMIATTGKMSEMEL	PRRC2C	2646	Q9Y520
MIAVIMAALMSSLTS	SLC5A9	386	Q2M3M2
MPSMVRHSLQTMLSV	TENM1	1916	Q9UKZ4
IGVMTSLLHISLMMH	OR7D2	151	Q96RA2
IVHAFASVSMMMDAT	PEX13	136	Q92968
TDMTLQQVLMAMSQI	RO60	426	P10155
SGQMVEHLMNSVMKL	AKAP3	666	O75969
SMNVSMMTPINDLHT	ADD2	106	P35612
SVLVNMDMSLHSMEV	CNOT11	396	Q9UKZ1
MDMSLHSMEVVNRLT	CNOT11	401	Q9UKZ1
MHQIVNIDLMLEMST	UFSP2	111	Q9NUQ7
FTHVMINKTDMLMIT	VPS13A	3076	Q96RL7
IMMFMEEHLHSTTVT	WDFY3	1671	Q8IZQ1
IHMTSEKHMQNVLML	ZFHX2	586	Q9C0A1
MTQIIHETDLLMNTM	STAT4	216	Q14765
MIFHNMAILEALMTV	STYXL2	241	Q5VZP5
SRAQQMALHTLKMMA	SPATA20	291	Q8TB22
MMSQRESLMSHAIEL	PLAA	676	Q9Y263
SRRMAIMNNMSLIIH	UGT1A5	111	P35504
MLVQSQSMTDMLLKV	TTC41P	846	Q6P2S7
SISVSLFLMVMMTAS	TLR7	846	Q9NYK1
MNIMMLTISDTPFIH	TLR6	331	Q9Y2C9
LTIRMMMKISNAQDH	TLCD1	151	Q96CP7
MSIMTQMKESEQELH	ZNFX1	716	Q9P2E3
HRMATLVMQSMAFLQ	TMEM231	146	Q9H6L2
EITINSMIETMLNIM	WDR87	876	Q6ZQQ6
SMIETMLNIMVHASL	WDR87	881	Q6ZQQ6
METHILASNTMDSQM	SON	721	P18583