Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNAL4 MYH6 KIF19	1.07e-04	118	16	3	GO:0003774
GeneOntologyMolecularFunction	ATP-dependent activity	DNAL4 CHD8 MYH6 KIF19	1.20e-03	614	16	4	GO:0140657
GeneOntologyMolecularFunction	microtubule motor activity	DNAL4 KIF19	1.41e-03	70	16	2	GO:0003777
GeneOntologyCellularComponent	supramolecular fiber	DNAL4 MYH6 RYR3 KIF19 CTNNB1 SMTN	1.56e-04	1179	16	6	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	DNAL4 MYH6 RYR3 KIF19 CTNNB1 SMTN	1.62e-04	1187	16	6	GO:0099081
GeneOntologyCellularComponent	Z disc	MYH6 RYR3 CTNNB1	1.93e-04	151	16	3	GO:0030018
GeneOntologyCellularComponent	I band	MYH6 RYR3 CTNNB1	2.55e-04	166	16	3	GO:0031674
GeneOntologyCellularComponent	sarcomere	MYH6 RYR3 CTNNB1	8.34e-04	249	16	3	GO:0030017
GeneOntologyCellularComponent	myofibril	MYH6 RYR3 CTNNB1	1.09e-03	273	16	3	GO:0030016
GeneOntologyCellularComponent	contractile muscle fiber	MYH6 RYR3 CTNNB1	1.29e-03	290	16	3	GO:0043292
Domain	ARM-type_fold	IPO5 TTI1 NBEAL2 RYR3 CTNNB1 NOC3L	2.35e-07	339	16	6	IPR016024
Domain	ARM-like	IPO5 TTI1 NBEAL2 CTNNB1 NOC3L	2.33e-06	270	16	5	IPR011989
Domain	-	IPO5 TTI1 CTNNB1	8.28e-04	222	16	3	1.25.10.10
Domain	P-loop_NTPase	GBP5 CHD8 MYH6 KIF19	4.96e-03	848	16	4	IPR027417
Domain	ConA-like_dom	NBEAL2 RYR3	1.47e-02	219	16	2	IPR013320
Pubmed	A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formation.	CHD8 CTNNB1	1.98e-07	2	16	2	10921920
Pubmed	CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes.	CHD8 CTNNB1	5.95e-07	3	16	2	18378692
Pubmed	Wild-type BRCA1, but not mutated BRCA1, regulates the expression of the nuclear form of beta-catenin.	CHD8 CTNNB1	5.95e-07	3	16	2	20215423
Pubmed	Nuclear localization of Duplin, a beta-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway.	CHD8 CTNNB1	1.98e-06	5	16	2	11744694
Pubmed	Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-β-catenin signaling pathway.	CHD8 CTNNB1	2.97e-06	6	16	2	22083958
Pubmed	Early embryonic death in mice lacking the beta-catenin-binding protein Duplin.	CHD8 CTNNB1	4.16e-06	7	16	2	15367660
Pubmed	Biophysical and functional study of CRL5Ozz, a muscle specific ubiquitin ligase complex.	MYH6 CTNNB1	7.13e-06	9	16	2	35551201
Pubmed	Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway.	MYH6 CTNNB1	1.31e-05	12	16	2	19690384
Pubmed	Differential effects of spinal motor neuron-derived and skeletal muscle-derived Rspo2 on acetylcholine receptor clustering at the neuromuscular junction.	CHAT CTNNB1	1.54e-05	13	16	2	30206360
Pubmed	β-Catenin Deletion in Regional Neural Progenitors Leads to Congenital Hydrocephalus in Mice.	CHAT CTNNB1	1.80e-05	14	16	2	34460072
Pubmed	Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects.	MYH6 CTNNB1	1.80e-05	14	16	2	17766470
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	IPO5 CHD8 CTNNB1 NOC3L	3.10e-05	410	16	4	26949251
Pubmed	TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction.	MYH6 CTNNB1	4.15e-05	21	16	2	20194497
Pubmed	Prokineticin receptor-1 signaling promotes Epicardial to Mesenchymal Transition during heart development.	MYH6 CTNNB1	4.15e-05	21	16	2	27150455
Pubmed	Cardiomyocyte Homeodomain-Interacting Protein Kinase 2 Maintains Basal Cardiac Function via Extracellular Signal-Regulated Kinase Signaling.	MYH6 CTNNB1	5.44e-05	24	16	2	31581792
Pubmed	APC controls asymmetric Wnt/β-catenin signaling and cardiomyocyte proliferation gradient in the heart.	MYH6 CTNNB1	6.41e-05	26	16	2	26493106
Pubmed	Phrenic-specific transcriptional programs shape respiratory motor output.	CHAT CTNNB1	6.92e-05	27	16	2	31944180
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	IPO5 TTI1 NBEAL2	7.63e-05	183	16	3	23956138
Pubmed	Reduced dosage of β-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndrome.	MYH6 CTNNB1	8.57e-05	30	16	2	28346476
Pubmed	Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.	CHD8 CTNNB1	1.10e-04	34	16	2	30894540
Pubmed	Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies.	MYH6 CTNNB1	1.17e-04	35	16	2	32179912
Pubmed	Axon guidance genes control hepatic artery development.	CTNNB1 SMTN	1.24e-04	36	16	2	37497580
Pubmed	Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals.	MYH6 CTNNB1	1.38e-04	38	16	2	21041481
Pubmed	Erk and MAPK signaling is essential for intestinal development through Wnt pathway modulation.	CHAT CTNNB1	2.12e-04	47	16	2	32747435
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	IPO5 CHD8 CTNNB1	2.73e-04	282	16	3	23667531
Pubmed	Mutation specific functions of EGFR result in a mutation-specific downstream pathway activation.	IPO5 SMTN	4.44e-04	68	16	2	25754235
Cytoband	Ensembl 112 genes in cytogenetic band chr20q11	TTI1 FAM83C	3.32e-03	248	16	2	chr20q11
Cytoband	Ensembl 112 genes in cytogenetic band chr14q11	CHD8 MYH6	5.85e-03	332	16	2	chr14q11
Coexpression	GSE17721_POLYIC_VS_CPG_4H_BMDC_DN	IPO5 CCNB3 MYH6 NOC3L	5.57e-06	200	16	4	M3942
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IPO5 MYH6 RYR3	2.91e-05	171	16	3	09e653973962fb884878089d281f0947f7a285f6
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IPO5 MYH6 RYR3	2.91e-05	171	16	3	82de2885c8ce4fb7776da6a0207b3355c0910121
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Monocytes,_Macrophages-Neutrophils\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IPO5 NBEAL2 NOC3L	3.23e-05	177	16	3	2dd6dd5193bda9ba1c6b299ec47890fdc92f88b1
Drug	Gabexate mesilate [56974-61-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A	IPO5 DNAL4 NBEAL2 SMTN	8.58e-06	194	16	4	4804_DN
Disease	Cardiomyopathy, Dilated	MYH6 CTNNB1	3.06e-04	48	16	2	C0007193
Disease	Cardiomyopathy, Familial Idiopathic	MYH6 CTNNB1	3.33e-04	50	16	2	C1449563
Disease	cancer (implicated_via_orthology)	IPO5 TTI1 CTNNB1	3.80e-04	268	16	3	DOID:162 (implicated_via_orthology)
Disease	Alzheimer's disease (biomarker_via_orthology)	CHAT CTNNB1	4.48e-04	58	16	2	DOID:10652 (biomarker_via_orthology)
Disease	common carotid intimal medial thickness	RYR3 NOC3L	5.97e-04	67	16	2	EFO_0004860
Disease	diabetic nephropathy	CHAT RYR3	2.94e-03	150	16	2	EFO_0000401
Disease	autism spectrum disorder (implicated_via_orthology)	CHD8 CTNNB1	3.02e-03	152	16	2	DOID:0060041 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
DPLMMMDEEISVIDG	CHD8	1711	Q9HCK8
EMMSICPELLDFQDM	CCNB3	541	Q8WWL7
DLMELDMAMEPDRKA	CTNNB1	6	P35222
DMPEEMRVETMELCV	DNAL4	26	O96015
MALEIHMSDPMCLIE	GBP5	1	Q96PP8
PQMLAMMVDLEEDED	IPO5	306	O00410
MVVLMDPMEDPDDIL	KIF19	41	Q2TAC6
VMDIFTDMELLCDLM	FAM83C	176	Q9BQN1
MELLDMVCMDPLVDD	C1orf112	136	Q9NSG2
ALPLDMMDEDDLQLM	NOC3L	86	Q8WTT2
SMLDAIPMMLACEDR	NBEAL2	306	Q6ZNJ1
EKPMGIMSILEEECM	MYH6	526	P13533
ARAMCKELPEMFMDE	CHAT	631	P28329
DDDEPDMKCDDMMTC	RYR3	4701	Q15413
LMELLVMHMEEPCFD	NRDC	936	O43847
VDCVPLVEVDDMMIM	SMTN	871	P53814
LETEEMGEELMMEHP	TTI1	576	O43156