Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	GTPase activator activity	AGAP5 LRRK2 AGAP9 AGAP7P AGAP4 AGAP6	1.55e-04	279	58	6	GO:0005096
GeneOntologyMolecularFunction	GTPase activity	AGAP5 LRRK2 AGAP9 AGAP7P AGAP4 AGAP6	4.55e-04	341	58	6	GO:0003924
GeneOntologyMolecularFunction	enzyme activator activity	AGAP5 LRRK2 AGAP9 AGAP7P MAPK9 AGAP4 AGAP6 CCNYL2	5.85e-04	656	58	8	GO:0008047
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	AGAP5 LRRK2 DOCK7 AGAP9 AGAP7P AGAP4 AGAP6	6.40e-04	507	58	7	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	AGAP5 LRRK2 DOCK7 AGAP9 AGAP7P AGAP4 AGAP6	6.40e-04	507	58	7	GO:0030695
GeneOntologyMolecularFunction	E-box binding	OLIG3 HIF1A NEUROD2	7.43e-04	61	58	3	GO:0070888
GeneOntologyMolecularFunction	GTP binding	AGAP5 LRRK2 AGAP9 AGAP7P AGAP4 AGAP6	1.01e-03	397	58	6	GO:0005525
GeneOntologyMolecularFunction	phospholipid binding	AGAP5 PTAFR AGAP9 AGAP7P AGAP4 AGAP6 ITPR1	1.01e-03	548	58	7	GO:0005543
GeneOntologyMolecularFunction	guanyl ribonucleotide binding	AGAP5 LRRK2 AGAP9 AGAP7P AGAP4 AGAP6	1.68e-03	439	58	6	GO:0032561
GeneOntologyMolecularFunction	guanyl nucleotide binding	AGAP5 LRRK2 AGAP9 AGAP7P AGAP4 AGAP6	1.68e-03	439	58	6	GO:0019001
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	AGAP5 KIF2B LRRK2 AGAP9 AGAP7P AGAP4 AGAP6 MOV10	1.71e-03	775	58	8	GO:0017111
GeneOntologyMolecularFunction	lipid binding	AGAP5 TEX2 DGKB PTAFR AGAP9 AGAP7P AGAP4 AGAP6 ITPR1	2.05e-03	988	58	9	GO:0008289
GeneOntologyMolecularFunction	pyrophosphatase activity	AGAP5 KIF2B LRRK2 AGAP9 AGAP7P AGAP4 AGAP6 MOV10	2.80e-03	839	58	8	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	AGAP5 KIF2B LRRK2 AGAP9 AGAP7P AGAP4 AGAP6 MOV10	2.82e-03	840	58	8	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	AGAP5 KIF2B LRRK2 AGAP9 AGAP7P AGAP4 AGAP6 MOV10	2.82e-03	840	58	8	GO:0016818
GeneOntologyBiologicalProcess	activation of GTPase activity	AGAP5 DOCK7 AGAP9 AGAP7P AGAP4 AGAP6	6.14e-07	109	58	6	GO:0090630
GeneOntologyBiologicalProcess	regulation of GTPase activity	AGAP5 LRRK2 DOCK7 AGAP9 AGAP7P AGAP4 AGAP6	4.14e-05	335	58	7	GO:0043087
GeneOntologyBiologicalProcess	positive regulation of GTPase activity	AGAP5 DOCK7 AGAP9 AGAP7P AGAP4 AGAP6	6.24e-05	244	58	6	GO:0043547
GeneOntologyBiologicalProcess	organelle assembly	FSIP2 HIF1A CEP85 CCNB2 CEP295NL LRRK2 DOCK7 AP1M1 CFAP61 MAPK9 SPAG5 SPICE1	6.32e-05	1138	58	12	GO:0070925
GeneOntologyBiologicalProcess	regulation of organelle assembly	HIF1A CEP295NL LRRK2 MAPK9 SPAG5 SPICE1	1.33e-04	280	58	6	GO:1902115
GeneOntologyBiologicalProcess	organelle localization	HIF1A KIF2B ATCAY LRRK2 DOCK7 RIMS2 CHAMP1 SPAG5 SPICE1	1.41e-04	703	58	9	GO:0051640
GeneOntologyBiologicalProcess	microtubule-based process	FSIP2 HIF1A CEP85 KIF2B CCNB2 CEP295NL TTC29 DOCK7 CFAP61 SPAG5 SPICE1	1.52e-04	1058	58	11	GO:0007017
GeneOntologyCellularComponent	keratohyalin granule	FLG FLG2	7.53e-05	5	58	2	GO:0036457
GeneOntologyCellularComponent	eukaryotic translation initiation factor 3 complex, eIF3m	EIF3C EIF3CL	2.69e-04	9	58	2	GO:0071541
MousePheno	fused cornea and lens	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	1.56e-08	24	48	5	MP:0001307
MousePheno	abnormal skin coloration	AGAP5 POLH DOCK7 AGAP9 AGAP7P AGAP4 AGAP6	2.65e-06	182	48	7	MP:0011239
MousePheno	abnormal iris morphology	AGAP5 TEX2 AGAP9 AGAP7P AGAP4 AGAP6 ITPR1	3.78e-06	192	48	7	MP:0001322
MousePheno	abnormal anterior uvea morphology	AGAP5 TEX2 AGAP9 AGAP7P AGAP4 AGAP6 ITPR1	4.79e-06	199	48	7	MP:0005194
MousePheno	abnormal lens development	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	6.74e-06	78	48	5	MP:0005545
MousePheno	persistence of hyaloid vascular system	AGAP5 TMCC2 YLPM1 AGAP9 AGAP7P AGAP4 AGAP6	1.01e-05	223	48	7	MP:0001289
MousePheno	absent pinna reflex	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	1.29e-05	89	48	5	MP:0006358
MousePheno	cornea opacity	AGAP5 NEUROD2 AGAP9 AGAP7P AGAP4 AGAP6	1.63e-05	159	48	6	MP:0001314
MousePheno	abnormal uvea morphology	AGAP5 TEX2 AGAP9 AGAP7P AGAP4 AGAP6 ITPR1	1.67e-05	241	48	7	MP:0005197
MousePheno	abnormal pinna reflex	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	2.38e-05	101	48	5	MP:0001485
MousePheno	increased circulating potassium level	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	5.69e-05	121	48	5	MP:0005627
MousePheno	abnormal hallux morphology	EIF3C EIF3CL	1.15e-04	5	48	2	MP:0009049
MousePheno	abnormal circulating potassium level	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	2.89e-04	171	48	5	MP:0002668
MousePheno	belly spot	DOCK7 EIF3C EIF3CL	3.70e-04	41	48	3	MP:0000373
MousePheno	head spot	EIF3C EIF3CL	5.11e-04	10	48	2	MP:0002939
MousePheno	abnormal potassium level	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	5.41e-04	196	48	5	MP:0020887
MousePheno	abnormal potassium ion homeostasis	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	5.66e-04	198	48	5	MP:0011978
MousePheno	abnormal vitreous body morphology	AGAP5 TMCC2 YLPM1 AGAP9 AGAP7P AGAP4 AGAP6	6.06e-04	429	48	7	MP:0002699
MousePheno	white spotting	DOCK7 EIF3C EIF3CL	6.65e-04	50	48	3	MP:0002938
MousePheno	hearing/vestibular/ear phenotype	AGAP5 POLH EIF3C SLITRK6 PTAFR AGAP9 AGAP7P AGAP4 AGAP6 EIF3CL	8.44e-04	905	48	10	MP:0005377
Domain	ArfGap	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	2.27e-08	29	56	5	SM00105
Domain	ARFGAP	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	2.27e-08	29	56	5	PS50115
Domain	ArfGAP	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	2.27e-08	29	56	5	IPR001164
Domain	ArfGap	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	2.27e-08	29	56	5	PF01412
Domain	EIF3C_N_dom	EIF3C EIF3CL	8.83e-06	2	56	2	IPR008905
Domain	eIF-3c_N	EIF3C EIF3CL	8.83e-06	2	56	2	PF05470
Domain	EIF3C	EIF3C EIF3CL	8.83e-06	2	56	2	IPR027516
Domain	Filaggrin	FLG FLG2	8.83e-06	2	56	2	IPR003303
Domain	Ankyrin_rpt-contain_dom	AGAP5 LRRK2 ANKRD17 AGAP9 AGAP7P AGAP4 AGAP6	1.04e-05	254	56	7	IPR020683
Domain	-	AGAP5 LRRK2 ANKRD17 AGAP9 AGAP4 AGAP6	9.61e-05	248	56	6	1.25.40.20
Domain	ANK_REP_REGION	AGAP5 ANKRD17 AGAP9 AGAP7P AGAP4 AGAP6	1.10e-04	254	56	6	PS50297
Domain	Ankyrin_rpt	AGAP5 LRRK2 ANKRD17 AGAP7P AGAP4 AGAP6	1.30e-04	262	56	6	IPR002110
Domain	PH	AGAP5 TEX2 AGAP9 AGAP7P AGAP4 AGAP6	1.79e-04	278	56	6	SM00233
Domain	PH_domain	AGAP5 TEX2 AGAP9 AGAP7P AGAP4 AGAP6	1.86e-04	280	56	6	IPR001849
Domain	ANK	AGAP5 ANKRD17 AGAP7P AGAP4 AGAP6	9.20e-04	251	56	5	SM00248
Domain	ANK_REPEAT	AGAP5 ANKRD17 AGAP7P AGAP4 AGAP6	9.54e-04	253	56	5	PS50088
Domain	PINT	EIF3C EIF3CL	1.03e-03	16	56	2	SM00088
Domain	PCI	EIF3C EIF3CL	1.17e-03	17	56	2	PF01399
Domain	PCI_dom	EIF3C EIF3CL	1.17e-03	17	56	2	IPR000717
Domain	PH_DOMAIN	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	1.47e-03	279	56	5	PS50003
Domain	S100_CABP	FLG FLG2	2.95e-03	27	56	2	PS00303
Domain	S_100	FLG FLG2	2.95e-03	27	56	2	PF01023
Domain	S100_Ca-bd_sub	FLG FLG2	3.17e-03	28	56	2	IPR013787
Domain	S100/CaBP-9k_CS	FLG FLG2	3.17e-03	28	56	2	IPR001751
Domain	S_100	FLG FLG2	3.17e-03	28	56	2	SM01394
Domain	Ank_2	AGAP5 ANKRD17 AGAP4 AGAP6	3.93e-03	215	56	4	PF12796
Domain	HLH	OLIG3 HIF1A NEUROD2	4.50e-03	111	56	3	PF00010
Domain	HLH	OLIG3 HIF1A NEUROD2	5.09e-03	116	56	3	SM00353
Domain	BHLH	OLIG3 HIF1A NEUROD2	5.22e-03	117	56	3	PS50888
Domain	bHLH_dom	OLIG3 HIF1A NEUROD2	5.34e-03	118	56	3	IPR011598
Domain	PH_dom-like	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	8.87e-03	426	56	5	IPR011993
Pathway	REACTOME_PTK6_PROMOTES_HIF1A_STABILIZATION	HIF1A LRRK2	6.98e-05	6	31	2	M27754
Pathway	REACTOME_PTK6_PROMOTES_HIF1A_STABILIZATION	HIF1A LRRK2	6.98e-05	6	31	2	MM15500
Pubmed	GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	1.36e-12	9	58	5	12640130
Pubmed	AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	2.71e-12	10	58	5	20664521
Pubmed	AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	4.96e-12	11	58	5	15381706
Pubmed	The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	1.38e-11	13	58	5	27713690
Pubmed	GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	2.14e-11	14	58	5	22453919
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	AGAP5 CEP85 AP1M1 AGAP9 AGAP7P PRAG1 AGAP4 AGAP6	3.07e-09	218	58	8	33378226
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	AGAP5 WASHC4 TEX2 ANKRD17 AGAP9 AGAP7P RIMS2 CHAMP1 AGAP4 AGAP6	1.65e-08	529	58	10	14621295
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	BRD8 WASHC4 CCNB2 YLPM1 CTNNBL1 EIF3C CHAMP1 SPAG5 MOV10 EIF3CL SPICE1 ITPR1	3.70e-07	1155	58	12	20360068
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	AGAP5 AGAP9 AGAP7P RIMS2 PRAG1 AGAP4 AGAP6	4.41e-07	281	58	7	28706196
Pubmed	Proximity interactions among centrosome components identify regulators of centriole duplication.	CEP85 CCNB2 DOCK7 SPAG5 SPICE1	7.58e-07	101	58	5	24613305
Pubmed	Knockdown of RNA N6-methyladenosine methyltransferase METTL3 represses Warburg effect in colorectal cancer via regulating HIF-1α.	METTL3 HIF1A	2.73e-06	2	58	2	33637677
Pubmed	Hypoxia-inducible factor-dependent regulation of platelet-activating factor receptor as a route for gram-positive bacterial translocation across epithelia.	HIF1A PTAFR	2.73e-06	2	58	2	20032301
Pubmed	Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage.	HIF1A LRRK2	2.73e-06	2	58	2	30420654
Pubmed	Pneumococcal infection of respiratory cells exposed to welding fumes; Role of oxidative stress and HIF-1 alpha.	HIF1A PTAFR	2.73e-06	2	58	2	28278175
Pubmed	The requirement of c-Jun N-terminal kinase 2 in regulation of hypoxia-inducing factor-1α mRNA stability.	HIF1A MAPK9	2.73e-06	2	58	2	22910906
Pubmed	Transcriptional regulation of mouse type 1 inositol 1,4,5-trisphosphate receptor gene by NeuroD-related factor.	NEUROD2 ITPR1	2.73e-06	2	58	2	10098882
Pubmed	EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis.	EIF3C EIF3CL	2.73e-06	2	58	2	36157221
Pubmed	Expression of filaggrin-2 protein in the epidermis of human skin diseases: a comparative analysis with filaggrin.	FLG FLG2	2.73e-06	2	58	2	24813994
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	AGAP5 CEP85 TEX2 AGAP9 AGAP7P AGAP4 AGAP6 ITPR1	2.94e-06	536	58	8	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	AGAP5 CEP85 TEX2 AGAP9 AGAP7P AGAP4 AGAP6 ITPR1	3.03e-06	538	58	8	10512203
Pubmed	HBXIP drives metabolic reprogramming in hepatocellular carcinoma cells via METTL3-mediated m6A modification of HIF-1α.	METTL3 HIF1A	8.19e-06	3	58	2	33305825
Pubmed	Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.	FLG FLG2	8.19e-06	3	58	2	23403047
Pubmed	GATA3 regulates FLG and FLG2 expression in human primary keratinocytes.	FLG FLG2	8.19e-06	3	58	2	28928464
Pubmed	Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.	FLG FLG2	8.19e-06	3	58	2	32437351
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	FLG APOOL YLPM1 SUPT16H DOCK7 CTNNBL1 EIF3C FLG2 CHAMP1 ZNF292	1.10e-05	1082	58	10	38697112
Pubmed	CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity.	KIF2B SPAG5	1.64e-05	4	58	2	20852589
Pubmed	Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.	EIF3C EIF3CL	1.64e-05	4	58	2	10504338
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	WASHC4 SUPT16H CTNNBL1 ANKRD17 AP1M1 EIF3C CHAMP1 MOV10	2.13e-05	704	58	8	29955894
Pubmed	Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype.	FLG FLG2	4.08e-05	6	58	2	27304082
Pubmed	Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.	AGAP5 AGAP9 AGAP4 AGAP6	4.34e-05	116	58	4	30652415
Pubmed	The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.	CTNNBL1 ANKRD17 EIF3C SPAG5 EIF3CL	5.63e-05	245	58	5	19521500
Pubmed	The chromatin-targeting protein Brd2 is required for neural tube closure and embryogenesis.	OLIG3 SLITRK6	5.71e-05	7	58	2	19362612
Pubmed	Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.	AGAP5 DGKB AGAP9 AGAP7P AGAP4 AGAP6	5.83e-05	405	58	6	38187761
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	YLPM1 DOCK7 CTNNBL1 EIF3C CHAMP1 MOV10	6.24e-05	410	58	6	26949251
Pubmed	The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer.	HIF1A LRRK2	7.60e-05	8	58	2	26751287
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	AGAP5 DGKB AGAP9 AGAP7P AGAP4 AGAP6	8.11e-05	430	58	6	32581705
Pubmed	The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.	EIF3C EIF3CL	9.77e-05	9	58	2	21292980
Pubmed	The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control.	EIF3C EIF3CL	9.77e-05	9	58	2	24003236
Pubmed	Human transcription factor protein interaction networks.	FLG BRD8 CEP85 DIS3L POLH YLPM1 ANKRD17 EIF3C FLG2 MOV10	1.15e-04	1429	58	10	35140242
Pubmed	mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.	EIF3C EIF3CL	1.22e-04	10	58	2	16286006
Pubmed	Conservation and diversity of eukaryotic translation initiation factor eIF3.	EIF3C EIF3CL	1.22e-04	10	58	2	8995409
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	APOOL YLPM1 SUPT16H CTNNBL1 EIF3C EIF3CL ITPR1	1.62e-04	701	58	7	30196744
Pubmed	Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice.	HIF1A MAPK9	1.78e-04	12	58	2	28436940
Pubmed	Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3.	EIF3C EIF3CL	1.78e-04	12	58	2	14519125
Pubmed	Reconstitution reveals the functional core of mammalian eIF3.	EIF3C EIF3CL	1.78e-04	12	58	2	17581632
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	CEP85 DIS3L YLPM1 DOCK7 ANKRD17 MOV10 ZNF292	1.97e-04	724	58	7	36232890
Pubmed	Global gene expression analysis in fetal mouse ovaries with and without meiosis and comparison of selected genes with meiosis in the testis.	ANKRD17 C6orf136	2.11e-04	13	58	2	17431699
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	RIMS2 SPICE1 ZNF292	2.32e-04	71	58	3	33541421
Pubmed	Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.	EIF3C EIF3CL	2.46e-04	14	58	2	18599441
Pubmed	Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.	EIF3C EIF3CL	2.83e-04	15	58	2	17322308
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	BRD8 YLPM1 ANKRD17 EIF3C CHAMP1 EIF3CL SPICE1	2.95e-04	774	58	7	15302935
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	CEP85 WASHC4 DIS3L CCNB2 DOCK7 AP1M1 EIF3C SPICE1	3.13e-04	1038	58	8	26673895
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	HIF1A YLPM1 SUPT16H RIMS2 MOV10	3.29e-04	358	58	5	32460013
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	CEP85 CCNB2 YLPM1 SUPT16H EIF3C MAPK9 SPICE1 ITPR1	3.36e-04	1049	58	8	27880917
Pubmed	Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c.	EIF3C EIF3CL	3.66e-04	17	58	2	34752747
Pubmed	The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.	ANKRD17 EIF3C SPAG5 EIF3CL	3.74e-04	203	58	4	35012549
Pubmed	Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain.	MAPK9 ITPR1	4.11e-04	18	58	2	16606357
Pubmed	Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.	YLPM1 DOCK7 MOV10	4.22e-04	87	58	3	17148452
Pubmed	Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.	EIF3C EIF3CL UBFD1	4.97e-04	92	58	3	10493829
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	SUPT16H DOCK7 EIF3C FLG2 MOV10	5.45e-04	400	58	5	35013556
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	FSIP2 TEX2 DOCK7 ANKRD17 AP1M1 PRAG1 SPICE1	5.58e-04	861	58	7	36931259
Pubmed	The key features of SARS-CoV-2 leader and NSP1 required for viral escape of NSP1-mediated repression.	EIF3C MOV10	5.62e-04	21	58	2	35232816
Pubmed	Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.	FLG FLG2	5.62e-04	21	58	2	19601998
Pubmed	Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation.	OLIG3 HIF1A NEUROD2	5.98e-04	98	58	3	18557763
Pubmed	m6A epitranscriptomic modification regulates neural progenitor-to-glial cell transition in the retina.	METTL3 ZNF292	6.18e-04	22	58	2	36459087
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	POLH DOCK7 ANKRD17 CHAMP1 SPAG5	6.65e-04	418	58	5	34709266
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	FLG YLPM1 SUPT16H AP1M1 EIF3C FLG2	6.87e-04	641	58	6	36057605
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	METTL3 BRD8 SUPT16H DOCK7 SPAG5 SPICE1	7.10e-04	645	58	6	25281560
Pubmed	Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.	BRD8 CEP85 SUPT16H CTNNBL1 UBFD1	7.16e-04	425	58	5	24999758
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	CEP85 DOCK7 ANKRD17 AP1M1 SPAG5 ITPR1	7.39e-04	650	58	6	38777146
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	YLPM1 DOCK7 AP1M1 EIF3C SPAG5 MOV10	7.57e-04	653	58	6	33742100
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	WASHC4 CCNB2 SUPT16H EIF3C MAPK9 PRAG1 EIF3CL	7.73e-04	910	58	7	36736316
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	YLPM1 SUPT16H DOCK7 CTNNBL1 EIF3C FLG2	8.00e-04	660	58	6	32780723
Pubmed	A chemical tool for blue light-inducible proximity photo-crosslinking in live cells.	CEP85 ANKRD17	8.00e-04	25	58	2	35211260
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	YLPM1 SUPT16H ANKRD17 MOV10 ITPR1	8.37e-04	440	58	5	34244565
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	HIF1A TMEM54 LRRK2 EIF3C RIMS2 CHAMP1 ITPRIPL1 ITPR1	8.82e-04	1215	58	8	15146197
Pubmed	Genetic loci influencing natural variations in femoral bone morphometry in mice.	EIF3C EIF3CL	9.34e-04	27	58	2	11518254
Pubmed	Unconventional myosin VI in the heart: Involvement in cardiac dysfunction progressing with age.	HIF1A MAPK9	9.34e-04	27	58	2	37169038
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	AGAP5 BRD8 APOOL CFAP61 AGAP9 AGAP7P AGAP4 AGAP6	1.02e-03	1242	58	8	30973865
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	BRD8 POLH YLPM1 CHAMP1	1.06e-03	268	58	4	33640491
Pubmed	Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord.	OLIG3 NEUROD2	1.08e-03	29	58	2	30846445
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	METTL3 SUPT16H DOCK7 ANKRD17 AP1M1 FLG2 MOV10 EIF3CL	1.10e-03	1257	58	8	36526897
Pubmed	POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.	FLG CEP85 WASHC4 SPAG5	1.19e-03	277	58	4	30745168
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	FLG SUPT16H EIF3C FLG2 MOV10	1.20e-03	477	58	5	31300519
Pubmed	Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage.	DOCK7 AP1M1 EIF3C	1.39e-03	131	58	3	28031328
Pubmed	Expression of genes involved in mammalian meiosis during the transition from egg to embryo.	METTL3 CCNB2	1.40e-03	33	58	2	11389549
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	NEUROD2 CTNNBL1 SLC28A3 MAPK9 ZNF582 ITPRIPL1	1.40e-03	736	58	6	29676528
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	METTL3 BRD8 YLPM1 SUPT16H CTNNBL1 CHAMP1 UBFD1	1.45e-03	1014	58	7	32416067
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	METTL3 BRD8 EIF3C CHAMP1 EIF3CL	1.51e-03	503	58	5	16964243
Pubmed	Mettl14-mediated m6A modification ensures the cell-cycle progression of late-born retinal progenitor cells.	METTL3 ZNF292	1.57e-03	35	58	2	37269288
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	FLG TEX2 CTNNBL1 RIMS2 MOV10 ITPR1	1.58e-03	754	58	6	35906200
Pubmed	Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC.	EIF3C EIF3CL	1.66e-03	36	58	2	16097034
Cytoband	Ensembl 112 genes in cytogenetic band chr10q11	AGAP9 AGAP7P AGAP4 AGAP6 CCNYL2	4.20e-06	188	58	5	chr10q11
Cytoband	10q11.23	AGAP7P AGAP6	8.08e-04	33	58	2	10q11.23
Cytoband	10q11.22	AGAP9 AGAP4	1.25e-03	41	58	2	10q11.22
Cytoband	17q22	C17orf67 KIF2B	1.43e-03	44	58	2	17q22
GeneFamily	ArfGAPs	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	3.95e-09	33	34	5	395
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	AGAP5 AGAP9 AGAP4 AGAP6	2.44e-08	17	34	4	1291
GeneFamily	Ankyrin repeat domain containing	AGAP5 ANKRD17 AGAP9 AGAP7P AGAP4 AGAP6	5.31e-06	242	34	6	403
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	3.89e-05	206	34	5	682
GeneFamily	EF-hand domain containing\|S100 fused type protein family	FLG FLG2	7.17e-05	7	34	2	1350
GeneFamily	Basic helix-loop-helix proteins	OLIG3 HIF1A NEUROD2	1.14e-03	110	34	3	420
GeneFamily	Cyclins	CCNB2 CCNYL2	1.26e-03	28	34	2	473
GeneFamily	EF-hand domain containing	FLG DGKB FLG2	7.96e-03	219	34	3	863
Coexpression	THEODOROU_MAMMARY_TUMORIGENESIS	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	1.84e-08	37	58	5	MM1121
Coexpression	GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_DN	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	4.52e-08	44	58	5	MM485
CoexpressionAtlas	dev gonad_e12.5_F_GermCellOvary_Oct_k-means-cluster#4_top-relative-expression-ranked_1000	CEP85 KHDC1L TEX2 RIMS2 C6orf136 SPICE1	4.70e-05	243	57	6	gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_k4_1000
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000	OLIG3 CEP85 KHDC1L TEX2 CCNB2 SUPT16H CFAP61 RIMS2 C6orf136 SPICE1	5.81e-05	820	57	10	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_M-2fold-vs-F_top305_305	WASHC4 APOOL SUPT16H SLITRK6 ZNF292 UBFD1	7.76e-05	266	57	6	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_250_M-vs-F-2X
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	POLH AGAP9 AGAP4 C6orf136 ZNF292	2.67e-06	168	58	5	8697b40b2ec2cce68ef3beb4792eb3eff29be053
ToppCell	ASK452-Immune-B_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	MZB1 DOCK7 EIF3C AGAP4 SPAG5	3.64e-06	179	58	5	c3cf49c069e66db16d2fce1de4c52a4c4fe7e832
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	WASHC4 LRRK2 EIF3C PTAFR EIF3CL	4.99e-06	191	58	5	c9f3bdb5c0a90268cab24a0fe4c3a8290fcedeb8
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	WASHC4 LRRK2 EIF3C PTAFR EIF3CL	5.12e-06	192	58	5	b86476037ddf8904c1d8a6b3763af7242c031cf3
ToppCell	distal-Hematologic-Plasmacytoid_Dendritic-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NEUROD2 MZB1 CHAMP1 PRAG1 FAM221B	5.66e-06	196	58	5	170629b9ae82e9a911b93e8739dcd38176fbecb4
ToppCell	Tracheal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	HIF1A APOOL DGKB RIMS2 SPICE1	5.95e-06	198	58	5	cbb63b255bdc92a557c5db1f08f7766ed9346607
Disease	cerebral palsy (implicated_via_orthology)	AGAP5 AGAP9 AGAP7P AGAP4 AGAP6	3.85e-12	10	53	5	DOID:1969 (implicated_via_orthology)
Disease	acute kidney failure (implicated_via_orthology)	HIF1A PTAFR	1.08e-03	27	53	2	DOID:3021 (implicated_via_orthology)
Disease	platelet measurement	TMCC2 LRRK2 DOCK7 MOV10	2.47e-03	315	53	4	EFO_0005036
Disease	transient cerebral ischemia (biomarker_via_orthology)	HIF1A PTAFR ITPR1	2.85e-03	157	53	3	DOID:224 (biomarker_via_orthology)
Disease	systolic blood pressure change measurement	OLIG3 SLC28A3	3.25e-03	47	53	2	EFO_0006944

Protein segments in the cluster

Peptide	Gene	Start	Entry
EQMEHPDMSLEIHYK	CEP295NL	521	Q96MC4
DLHMHHVRDREMPEA	AGAP4	61	Q96P64
EDHDDLMPIFMRYDT	CFAP61	191	Q8NHU2
DPSMEEHLSVMYERL	C6orf136	141	Q5SQH8
GEDLHMHQVRDREMP	AGAP9	201	Q5VTM2
IQEMHVVATMPDLYH	CTNNBL1	121	Q8WYA6
DHHVYHMAVEMRQEV	BRD8	1186	Q9H0E9
YRGDVDMSEVEHFMP	AP1M1	21	Q9BXS5
PDMVDVFMDHLDIDH	FLG	51	P20930
YTPLMEAAREGHEEM	ANKRD17	501	O75179
DLHMHHVRDREMPEA	AGAP6	61	Q5VW22
CQVIHMELDHERMSY	MAPK9	116	P45984
PDTVDVIMHMLDRDH	FLG2	51	Q5D862
ERDRMDENSPLMYHI	ITPR1	1371	Q14643
THPCDHEEMREMLTH	HIF1A	136	Q16665
EQEHRIDLHMIRPYM	ATCAY	161	Q86WG3
HTLDPMCDIAEDMVH	FSIP2	811	Q5CZC0
GLHMHHICEREMPED	CCNYL2	61	Q5T2Q4
MEAHEIIEEPHITMD	FAM221B	1	A6H8Z2
EDGHFPAHREVMLSM	LRRK2	391	Q5S007
HMELPYGTLTDDEMR	METTL3	401	Q86U44
RASSPDMDEMYLRDH	OLIG3	11	Q7RTU3
MDRHRVMDDHYSPDR	RIMS2	1061	Q9UQ26
YVVHHPLMVSDRMDL	ITPRIPL1	21	Q6GPH6
MLLEIPYMAAHESDA	EIF3C	691	Q99613
AMLLEIPYMAAHESD	EIF3CL	691	B5ME19
EHQEDPEMLIDLMYR	DOCK7	1661	Q96N67
MELTLIDYDMVHYHP	CCNB2	291	O95067
IHMGTIHPEFCDEMD	CHAMP1	31	Q96JM3
YHHCQDRMPIVMVTE	DIS3L	151	Q8TF46
SAMMETLYSDPHHRV	CEP85	191	Q6P2H3
FPDEPMREYMHHLLA	C17orf67	46	Q0P5P2
NPILHEMMEEIDYDH	DGKB	196	Q9Y6T7
DLHMHHVRDREMPEA	AGAP7P	61	Q5VUJ5
HSPMVFHMEEDQEEL	KHDC1L	21	Q5JSQ8
EIMHMIEEYRRHLDS	KIF2B	186	Q8N4N8
MDHGQSHPEDIDMYS	APOOL	251	Q6UXV4
EHGAMEEREMRFPTH	SPAG5	271	Q96R06
MEAHYPGAHEELKLM	SLITRK6	786	Q9H5Y7
SPEMHRVSYAMSLHD	TMCC2	126	O75069
MEHDIRHYDLESVPM	MOV10	351	Q9HCE1
MEPHDSSHMDSEFRY	PTAFR	1	P25105
DMPEHMDYHFALELQ	POLH	646	Q9Y253
HLMAKYEHRIDEMLS	SLC28A3	146	Q9HAS3
HMHDRDDLYAEQMER	SUPT16H	756	Q9Y5B9
HMIHEVEHEMEEYER	SPICE1	336	Q8N0Z3
DLHMHHIRDQEMPEA	AGAP5	61	A6NIR3
SEPIEGHEDYHMMAF	UBFD1	261	O14562
HHMMRENPELVEGRD	TMEM54	196	Q969K7
QHYMKLHEMTPEEIE	ZNF292	2191	O60281
VMAAHPEEDHRTIYL	PRAG1	476	Q86YV5
YPSDVDRHSPMAEHM	YLPM1	1406	P49750
DRHFHQMIIRHEEMP	ZNF582	136	Q96NG8
EAEAHMHMGLLYEED	TTC29	181	Q8NA56
VPAMMHARHLESYEI	WASHC4	641	Q2M389
DDVYITIMHSAMDPR	TEX2	1096	Q8IWB9
DEEMYSAHMPAHLRC	MZB1	36	Q8WU39
YDMHLHHDRGPMYEE	NEUROD2	361	Q15784