Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF729 ZNF355P ZNF611 ZNF93 ZNF808 ZNF85 ZNF99 ZNF257 ZNF652 SMYD3 ZNF283	1.40e-06	1244	31	11	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF729 ZNF355P ZNF611 ZNF93 ZNF808 ZNF85 ZNF99 ZNF257 ZNF652 SMYD3 ZNF283	1.72e-06	1271	31	11	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF729 ZNF355P ZNF611 ZBTB47 ZNF93 ZNF808 ZNF85 ZNF99 ZNF257 ZNF652 ZNF283	4.80e-06	1412	31	11	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF729 ZNF355P ZNF611 ZNF93 ZNF808 ZNF85 ZNF99 ZNF257 ZNF652 SMYD3 ZNF283	6.58e-06	1459	31	11	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZNF729 ZNF93 ZNF85 ZNF99	1.45e-03	320	31	4	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	ZNF729 ZNF93 ZNF85 ZNF99	1.55e-03	326	31	4	GO:0001217
GeneOntologyMolecularFunction	histone methyltransferase activity	EED SMYD3	5.42e-03	71	31	2	GO:0042054
GeneOntologyBiologicalProcess	transposable element silencing	ZNF729 ZNF93 ZNF99	4.47e-05	46	31	3	GO:0010526
GeneOntologyBiologicalProcess	retrotransposition	ZNF729 ZNF93 ZNF99	5.08e-05	48	31	3	GO:0032197
GeneOntologyBiologicalProcess	transposition	ZNF729 ZNF93 ZNF99	5.74e-05	50	31	3	GO:0032196
Domain	zf-C2H2_6	ZNF729 ZNF611 ZBTB47 ZNF93 ZNF808 ZNF85 ZNF99 ZNF652 ZNF283	1.00e-09	314	30	9	PF13912
Domain	-	ZNF729 ZNF611 ZBTB47 ZNF93 ZNF808 ZNF85 ZNF99 ZNF257 ZNF652 ZNF283	5.87e-08	679	30	10	3.30.160.60
Domain	KRAB	ZNF729 ZNF611 ZNF93 ZNF808 ZNF85 ZNF99 ZNF257 ZNF283	6.83e-08	358	30	8	PS50805
Domain	KRAB	ZNF729 ZNF611 ZNF93 ZNF808 ZNF85 ZNF99 ZNF257 ZNF283	6.83e-08	358	30	8	PF01352
Domain	zf-C2H2	ZNF729 ZNF611 ZBTB47 ZNF93 ZNF808 ZNF85 ZNF99 ZNF257 ZNF652 ZNF283	7.11e-08	693	30	10	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF729 ZNF611 ZBTB47 ZNF93 ZNF808 ZNF85 ZNF99 ZNF257 ZNF652 ZNF283	7.20e-08	694	30	10	IPR013087
Domain	KRAB	ZNF729 ZNF611 ZNF93 ZNF808 ZNF85 ZNF99 ZNF257 ZNF283	8.61e-08	369	30	8	SM00349
Domain	KRAB	ZNF729 ZNF611 ZNF93 ZNF808 ZNF85 ZNF99 ZNF257 ZNF283	8.80e-08	370	30	8	IPR001909
Domain	ZINC_FINGER_C2H2_2	ZNF729 ZNF611 ZBTB47 ZNF93 ZNF808 ZNF85 ZNF99 ZNF257 ZNF652 ZNF283	2.02e-07	775	30	10	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF729 ZNF611 ZBTB47 ZNF93 ZNF808 ZNF85 ZNF99 ZNF257 ZNF652 ZNF283	2.07e-07	777	30	10	PS00028
Domain	Znf_C2H2-like	ZNF729 ZNF611 ZBTB47 ZNF93 ZNF808 ZNF85 ZNF99 ZNF257 ZNF652 ZNF283	2.58e-07	796	30	10	IPR015880
Domain	Znf_C2H2	ZNF729 ZNF611 ZBTB47 ZNF93 ZNF808 ZNF85 ZNF99 ZNF257 ZNF652 ZNF283	2.87e-07	805	30	10	IPR007087
Domain	ZnF_C2H2	ZNF729 ZNF611 ZBTB47 ZNF93 ZNF808 ZNF85 ZNF99 ZNF257 ZNF652 ZNF283	2.97e-07	808	30	10	SM00355
Domain	C-type_lectin_CS	MRC1 REG1B LY75	4.42e-05	43	30	3	IPR018378
Domain	FN_type2_col-bd	MRC1 LY75	2.24e-04	14	30	2	IPR000562
Domain	FN2_2	MRC1 LY75	2.24e-04	14	30	2	PS51092
Domain	fn2	MRC1 LY75	2.24e-04	14	30	2	PF00040
Domain	FN2_1	MRC1 LY75	2.24e-04	14	30	2	PS00023
Domain	FN2	MRC1 LY75	2.24e-04	14	30	2	SM00059
Domain	C_TYPE_LECTIN_1	MRC1 REG1B LY75	2.83e-04	80	30	3	PS00615
Domain	Lectin_C	MRC1 REG1B LY75	3.26e-04	84	30	3	PF00059
Domain	CLECT	MRC1 REG1B LY75	3.26e-04	84	30	3	SM00034
Domain	C_TYPE_LECTIN_2	MRC1 REG1B LY75	3.38e-04	85	30	3	PS50041
Domain	C-type_lectin-like	MRC1 REG1B LY75	3.50e-04	86	30	3	IPR001304
Domain	zf-MYND	ANKMY1 SMYD3	5.14e-04	21	30	2	PF01753
Domain	C-type_lectin-like/link	MRC1 REG1B LY75	5.29e-04	99	30	3	IPR016186
Domain	Znf_MYND	ANKMY1 SMYD3	5.65e-04	22	30	2	IPR002893
Domain	ZF_MYND_1	ANKMY1 SMYD3	5.65e-04	22	30	2	PS01360
Domain	ZF_MYND_2	ANKMY1 SMYD3	5.65e-04	22	30	2	PS50865
Domain	CTDL_fold	MRC1 REG1B LY75	6.63e-04	107	30	3	IPR016187
Domain	RICIN	MRC1 LY75	9.19e-04	28	30	2	SM00458
Domain	RICIN_B_LECTIN	MRC1 LY75	9.19e-04	28	30	2	PS50231
Domain	Ricin_B_lectin	MRC1 LY75	1.06e-03	30	30	2	IPR000772
Domain	Kringle-like	MRC1 LY75	1.20e-03	32	30	2	IPR013806
Domain	-	MRC1 REG1B	1.06e-02	97	30	2	3.10.100.10
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	ZNF729 ZNF355P ZNF93 ZNF808 EED ZNF85 ZNF99	8.22e-05	768	21	7	MM14851
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	ZNF729 ZNF355P ZNF93 ZNF808 EED ZNF85 ZNF99	4.86e-04	1022	21	7	MM15436
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF729 ZNF355P ZNF93 ZNF85 ZNF99	4.69e-11	29	31	5	14563677
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF729 ZNF355P ZNF93 ZNF99	7.00e-10	15	31	4	15885501
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF729 ZNF355P ZNF85 ZNF99	1.06e-07	49	31	4	9630514
Pubmed	Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.	ZNF93 ZNF85 ZNF99	3.56e-07	16	31	3	8467795
Pubmed	CD44 binds to macrophage mannose receptor on lymphatic endothelium and supports lymphocyte migration via afferent lymphatics.	MRC1 LY75	4.61e-06	4	31	2	23603511
Pubmed	The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons.	ZNF355P ZNF93	1.15e-05	6	31	2	30846446
Pubmed	Intronic RNAs mediate EZH2 regulation of epigenetic targets.	EED SMYD3	1.61e-05	7	31	2	22659877
Pubmed	The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.	ZNF93 ZNF85	2.15e-05	8	31	2	2023909
Pubmed	Functional analysis of the SRY-KRAB interaction in mouse sex determination.	ZNF729 ZNF99	3.44e-05	10	31	2	18588511
Pubmed	Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.	ZNF729 ZNF99	4.21e-05	11	31	2	15469996
Pubmed	Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.	ZNF729 ZNF99	5.96e-05	13	31	2	19850934
Pubmed	Genome-wide and candidate gene association study of cigarette smoking behaviors.	ZNF93 MAOA	5.96e-05	13	31	2	19247474
Pubmed	Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.	TENM3 ZNF652	1.30e-04	19	31	2	14671302
Pubmed	Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.	ZNF355P ZNF93	1.45e-04	20	31	2	2542606
Pubmed	Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.	ZNF355P ZNF93	1.45e-04	20	31	2	7479878
Pubmed	A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.	ASPM UTP6 ZNF85 LTN1	5.05e-04	419	31	4	28700943
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF611 ZNF93 ZNF257	5.60e-04	181	31	3	37372979
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF729 ZNF93 ZNF85 ZNF99 ZNF257	2.32e-08	122	32	5	chr19p12
Cytoband	19p12	ZNF729 ZNF93 ZNF85 ZNF99	4.76e-07	90	32	4	19p12
Cytoband	21q22.11	IL10RB LTN1	8.67e-04	62	32	2	21q22.11
Cytoband	19q13.41	ZNF611 ZNF808	1.37e-03	78	32	2	19q13.41
Cytoband	Ensembl 112 genes in cytogenetic band chr7q21	CALCR PTTG1IP2	6.87e-03	178	32	2	chr7q21
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF729 ZNF611 ZBTB47 ZNF93 ZNF808 ZNF85 ZNF99 ZNF257 ZNF652 ZNF283	1.08e-08	718	24	10	28
GeneFamily	Zinc fingers MYND-type	ANKMY1 SMYD3	3.49e-04	21	24	2	87
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	MRC1 LY75	5.81e-04	27	24	2	1253
GeneFamily	C-type lectin domain family	MRC1 LY75	1.76e-03	47	24	2	494
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	IL10RB MRC1 LY75	1.48e-02	394	24	3	471
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Papillary_Adenocarcinoma-4\|TCGA-Lung / Sample_Type by Project: Shred V9	ZNF729 REG1B CALCR ZNF99	1.20e-06	111	32	4	bcecf3498a5fbd52dcdf56e68858b2da39d96ba9
Disease	oropharynx cancer	TENM3 STK31	9.40e-04	46	29	2	EFO_1001931
Disease	longitudinal BMI measurement	CALCR ZNF257	2.95e-03	82	29	2	EFO_0005937
Disease	telomere length	ZNF729 TENM3 ZNF257	3.52e-03	313	29	3	EFO_0004505
Disease	smoking behavior	ZNF93 EED MAOA	4.47e-03	341	29	3	EFO_0004318
Disease	lifestyle measurement, depressive symptom measurement	CALCR SMYD3	4.78e-03	105	29	2	EFO_0007006, EFO_0010724
Disease	Cocaine Dependence	MAOA TENM3	8.23e-03	139	29	2	C0600427
Disease	myocardial infarction (biomarker_via_orthology)	REG1B MDK	1.08e-02	160	29	2	DOID:5844 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QIDEYFSKCVSKKCW	AKAP14	81	Q86UN6
EKVTKYCDEKGVWFK	CALCR	106	P30988
LDIYRKKCVWKSKCG	AASDH	881	Q4L235
YLCKVKAACKIQAWY	ASPM	2951	Q8IZT6
TCKKKFHSACLYKWF	LTN1	1736	O94822
KEAFWKKKDYCGCMI	MAOA	311	P21397
WKKEFGADCKYKFEN	MDK	76	P21741
DKKYLYRACKFAEWC	LANCL2	386	Q9NS86
YCKKKVWTKAASQCM	PDZD8	856	Q8NEN9
QWKVQSCEEKLKYVC	LY75	471	O60449
GKWKSKKCKYSFKCV	EED	71	O75530
EDKKCVWCSEEKACK	PTTG1IP2	61	P0DTF9
YCKTKAWTEFHKKDC	ANKMY1	906	Q9P2S6
CFALLWCVYKKTKYA	IL10RB	241	Q08334
FKKWKDESCEKKFSF	REG1B	146	P48304
LWDVLKCDEKAKFVC	MRC1	611	P22897
KCDEKAKFVCKHWAE	MRC1	616	P22897
WKCYITFCLERFTKK	UTP6	326	Q9NYH9
AKFTKAAKDYCATKW	ENTPD4	451	Q9Y227
RVAKYCSAKCQKKAW	SMYD3	66	Q9H7B4
SDEILKKFYDWKCDK	STK31	491	Q9BXU1
KKFYDWKCDKREEFT	STK31	496	Q9BXU1
KKHYKCEECGKAFIW	ZNF93	366	P35789
YKCEECGKAFKWSSK	ZNF99	481	A8MXY4
EKSYKCKVCDKAFVC	ZNF808	676	Q8N4W9
FKFKKSSKYCSWKCT	TENM3	296	Q9P273
AEKKFSCEICEKKFY	ZBTB47	516	Q9UFB7
EKSYKCKVCDKAFVW	ZNF611	451	Q8N823
YKCEECDKAFKWSSV	ZNF85	566	Q03923
LYESVDKQKWCDVCK	TTC37	106	Q6PGP7
KLYKCEECGKAFKWS	ZNF355P	361	Q9NSJ1
EKKFSCEICEKKFYT	ZNF652	326	Q9Y2D9
YKCEECGKAFKWSSK	ZNF729	376	A6NN14
YKCEECGKAFKWSSK	ZNF729	796	A6NN14
VKSYKCKECGKAFFW	ZNF283	316	Q8N7M2
KYDECCKAFKWSSAL	ZNF257	286	Q9Y2Q1