Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiongalactosylceramidase activity

GALC LCT GBA2 GBA3

3.39e-0851834GO:0004336
GeneOntologyMolecularFunctionbeta-glucosidase activity

LCT GBA2 GBA3 KL

1.01e-0761834GO:0008422
GeneOntologyMolecularFunctionhydrolase activity, hydrolyzing O-glycosyl compounds

GALC MANBA LCT GBA2 GBA3 KL OTOGL EDEM2 HYAL2

4.48e-071031839GO:0004553
GeneOntologyMolecularFunctionapyrase activity

ENTPD1 ENTPD3 ENTPD8

7.57e-0731833GO:0004050
GeneOntologyMolecularFunctionglucosylceramidase activity

LCT GBA2 GBA3

3.01e-0641833GO:0004348
GeneOntologyMolecularFunctioncarbohydrate binding

P4HA2 CRYBG2 MANBA ACR ADGRL1 BCAN PKD1L2 PGD PKD1 CRYBG1 C4A C4B ZG16

6.00e-0631018313GO:0030246
GeneOntologyMolecularFunctionhydrolase activity, acting on glycosyl bonds

GALC MANBA LCT GBA2 GBA3 KL OTOGL EDEM2 HYAL2

7.36e-061441839GO:0016798
GeneOntologyMolecularFunctionglucosidase activity

LCT GBA2 GBA3 KL

8.61e-06151834GO:0015926
GeneOntologyMolecularFunctionUDP phosphatase activity

ENTPD1 ENTPD3 ENTPD8

6.11e-0591833GO:0045134
GeneOntologyMolecularFunctionopsonin binding

ITGAM CFHR4 C4A C4B

7.43e-05251834GO:0001846
GeneOntologyMolecularFunctionglycosylceramidase activity

LCT GBA3

8.35e-0521832GO:0017042
GeneOntologyMolecularFunctionphosphoenolpyruvate carboxykinase activity

PCK1 PCK2

8.35e-0521832GO:0004611
GeneOntologyMolecularFunctionphosphoenolpyruvate carboxykinase (GTP) activity

PCK1 PCK2

8.35e-0521832GO:0004613
GeneOntologyMolecularFunctionGDP phosphatase activity

ENTPD1 ENTPD3 ENTPD8

1.57e-04121833GO:0004382
GeneOntologyMolecularFunctioncomplement binding

ITGAM CFHR4 C4A C4B

2.01e-04321834GO:0001848
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

TRPM6 TRPM4 SLC5A10 PKD1L1 SLC5A7 PKD1L2 RYR2 TFRC SLC6A9 SLC6A13 PKD1 SLC5A8 KCNK17

3.72e-0446518313GO:0046873
GeneOntologyMolecularFunctionsymporter activity

SLC5A10 SLC5A7 SLC45A4 SLC6A9 SLC6A13 SLC16A14 SLC5A8

4.74e-041501837GO:0015293
GeneOntologyMolecularFunctionN-acetylmuramoyl-L-alanine amidase activity

PGLYRP4 PGLYRP1

4.95e-0441832GO:0008745
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

GABRB1 TRPM6 GABRD SLC37A1 TRPM4 SLC5A10 PKD1L1 SLC5A7 PKD1L2 RYR2 SLC45A4 TFRC SLC6A9 SLC6A13 PKD1 SLC5A8 KCNK17

6.26e-0475818317GO:0015318
GeneOntologyMolecularFunctionpeptidoglycan binding

PGLYRP4 PGLYRP1 ZG16

6.59e-04191833GO:0042834
GeneOntologyMolecularFunctionnucleoside diphosphate phosphatase activity

ENTPD1 ENTPD3 ENTPD8

7.70e-04201833GO:0017110
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC5A10 SLC5A7 SLC45A4 SLC6A9 SLC6A13 SLC5A8

8.05e-041191836GO:0015294
GeneOntologyMolecularFunctionpeptidoglycan immune receptor activity

PGLYRP4 PGLYRP1

8.20e-0451832GO:0016019
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC5A10 SLC5A7 SLC6A9 SLC6A13 SLC5A8

8.93e-04811835GO:0015370
GeneOntologyMolecularFunctionphosphotyrosine residue binding

SOCS3 CBLC CBL PIK3R1

1.22e-03511834GO:0001784
GeneOntologyMolecularFunctioncalcium channel activity

TRPM6 TRPM4 PKD1L1 PKD1L2 RYR2 PKD1

1.22e-031291836GO:0005262
GeneOntologyMolecularFunctionNAD+-protein-arginine ADP-ribosyltransferase activity

ARF4 ART5

1.70e-0371832GO:0106274
GeneOntologyMolecularFunctionankyrin repeat binding

SHANK1 TNKS1BP1

1.70e-0371832GO:0071532
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

TRPM6 TRPM4 SLC5A10 PKD1L1 SLC5A7 PKD1L2 RYR2 SLC45A4 TFRC SLC6A9 SLC6A13 PKD1 SLC5A8 KCNK17

1.97e-0362718314GO:0022890
GeneOntologyMolecularFunctionaspartic endopeptidase activity, intramembrane cleaving

SPPL2A SPPL2C

2.26e-0381832GO:0042500
GeneOntologyMolecularFunctionprotein tyrosine kinase inhibitor activity

SOCS3 HYAL2

2.26e-0381832GO:0030292
GeneOntologyMolecularFunctionhyaluronic acid binding

BCAN ITIH4 HYAL2

2.32e-03291833GO:0005540
GeneOntologyBiologicalProcessglycosylceramide catabolic process

GALC LCT GBA2 GBA3

2.75e-06121824GO:0046477
GeneOntologyBiologicalProcessglycosylceramide metabolic process

GALC LCT GBA2 GBA3

3.79e-05221824GO:0006677
GeneOntologyBiologicalProcessglycosphingolipid catabolic process

GALC LCT GBA2 GBA3

5.43e-05241824GO:0046479
GeneOntologyBiologicalProcessceramide catabolic process

GALC LCT GBA2 GBA3

7.53e-05261824GO:0046514
GeneOntologyBiologicalProcesspropionate catabolic process

PCK1 PCK2

7.74e-0521822GO:0019543
GeneOntologyBiologicalProcessglycerol biosynthetic process from pyruvate

PCK1 PCK2

7.74e-0521822GO:0046327
GeneOntologyBiologicalProcessglycolipid catabolic process

GALC LCT GBA2 GBA3

8.78e-05271824GO:0019377
GeneOntologyCellularComponentside of membrane

ICOSLG ITGA11 SOCS3 BCAN ITGA2B LCT ITGAE ITGAM CD163 RYR2 CFHR4 TFRC CD1D SPPL2A NPTXR CD163L1 ENTPD1 GLIPR1L1 CD200R1L ALG6 SPPL2C HYAL2

1.36e-0587518822GO:0098552
GeneOntologyCellularComponentsymbiont cell surface

CFHR4 C4A C4B

3.88e-0581883GO:0106139
GeneOntologyCellularComponentother organism part

CFHR4 C4A C4B

5.78e-0591883GO:0044217
GeneOntologyCellularComponentintegrin complex

ITGA11 ITGA2B ITGAE ITGAM

1.87e-04321884GO:0008305
GeneOntologyCellularComponentprotein complex involved in cell adhesion

ITGA11 ITGA2B ITGAE ITGAM GLIPR1L1

1.88e-04591885GO:0098636
GeneOntologyCellularComponentexternal side of plasma membrane

ICOSLG ITGA11 ITGA2B LCT ITGAE ITGAM CD163 CFHR4 TFRC CD1D CD163L1 ENTPD1 CD200R1L HYAL2

2.65e-0451918814GO:0009897
GeneOntologyCellularComponentsomatodendritic compartment

GABRB1 CHL1 SHANK1 GABRD CNTNAP3B TRPM4 SRD5A2 RAPGEF4 CNTNAP3 SLC5A7 BACE1 BCAN GRM8 ARF4 CFHR4 DIP2A HMCN2 NPTXR ASL ENTPD1 C4A C4B C9orf72 KLHL17

2.84e-04122818824GO:0036477
GeneOntologyCellularComponentaxon

GABRD CNTNAP3B FKBP15 MYO9A RAPGEF4 INSRR CNTNAP3 SLC5A7 BACE1 ADGRL1 BCAN CBL CFHR4 HMCN2 NPTXR C4A C4B C9orf72 DYNC1I1

4.46e-0489118819GO:0030424
GeneOntologyCellularComponentneuronal cell body

GABRD CNTNAP3B TRPM4 SRD5A2 RAPGEF4 CNTNAP3 SLC5A7 BACE1 GRM8 CFHR4 HMCN2 NPTXR ASL ENTPD1 C4A C4B C9orf72 KLHL17

5.57e-0483518818GO:0043025
GeneOntologyCellularComponentGolgi-associated vesicle

ACR BACE1 SPPL2A AP1G1 PKD1 SPPL2C

5.83e-041141886GO:0005798
GeneOntologyCellularComponentcell body

GABRD CNTNAP3B TRPM4 SRD5A2 RAPGEF4 CNTNAP3 SLC5A7 BACE1 CCT7 GRM8 CFHR4 HMCN2 NPTXR ASL ENTPD1 C4A C4B C9orf72 KLHL17

7.38e-0492918819GO:0044297
GeneOntologyCellularComponent3M complex

OBSL1 FBXW8

7.90e-0451882GO:1990393
DomainWD_REPEATS_1

WDR64 WDR5B DYNC2I2 COP1 PIK3R4 FBXW8 NWD2 GTF3C2 CDC40 TULP4 KCTD3 TLE6 IFT80 CFAP57 HERC2 HERC1 DYNC1I1 RIC1 TBL1X SEC13

4.51e-1227818420PS00678
DomainWD_REPEATS_2

WDR64 WDR5B DYNC2I2 COP1 PIK3R4 FBXW8 NWD2 GTF3C2 CDC40 TULP4 KCTD3 TLE6 IFT80 CFAP57 HERC2 HERC1 DYNC1I1 RIC1 TBL1X SEC13

4.82e-1227918420PS50082
DomainWD_REPEATS_REGION

WDR64 WDR5B DYNC2I2 COP1 PIK3R4 FBXW8 NWD2 GTF3C2 CDC40 TULP4 KCTD3 TLE6 IFT80 CFAP57 HERC2 HERC1 DYNC1I1 RIC1 TBL1X SEC13

4.82e-1227918420PS50294
DomainWD40_repeat_dom

WDR64 WDR5B DYNC2I2 COP1 LRRK1 PIK3R4 FBXW8 NWD2 GTF3C2 CDC40 TULP4 KCTD3 TLE6 IFT80 CFAP57 HERC1 DYNC1I1 RIC1 TBL1X SEC13

1.51e-1129718420IPR017986
DomainWD40_repeat

WDR64 WDR5B DYNC2I2 COP1 PIK3R4 FBXW8 NWD2 GTF3C2 CDC40 TULP4 KCTD3 TLE6 IFT80 CFAP57 HERC2 HERC1 DYNC1I1 TBL1X SEC13

2.66e-1127218419IPR001680
DomainWD40

WDR64 WDR5B DYNC2I2 COP1 PIK3R4 FBXW8 NWD2 GTF3C2 CDC40 TULP4 KCTD3 TLE6 IFT80 CFAP57 HERC1 DYNC1I1 TBL1X SEC13

1.73e-1026818418SM00320
Domain-

WDR64 WDR5B DYNC2I2 COP1 PIK3R4 FBXW8 NWD2 GTF3C2 CDC40 TULP4 KCTD3 TLE6 IFT80 CFAP57 HERC1 DYNC1I1 RIC1 TBL1X SEC13

8.34e-10333184192.130.10.10
DomainWD40/YVTN_repeat-like_dom

WDR64 WDR5B DYNC2I2 COP1 PIK3R4 FBXW8 NWD2 GTF3C2 CDC40 TULP4 KCTD3 TLE6 IFT80 CFAP57 HERC1 DYNC1I1 RIC1 TBL1X SEC13

9.22e-1033518419IPR015943
DomainWD40

WDR64 WDR5B DYNC2I2 COP1 PIK3R4 FBXW8 GTF3C2 CDC40 TULP4 TLE6 IFT80 CFAP57 HERC1 DYNC1I1 TBL1X SEC13

6.23e-0925918416PF00400
DomainGlyco_hydro_1_N_CS

LCT GBA3 KL

3.74e-0641843IPR033132
DomainGlyco_hydro_1_AS

LCT GBA3 KL

3.74e-0641843IPR018120
DomainREJ

PKD1L1 PKD1L2 PKD1

3.74e-0641843PS51111
DomainREJ_dom

PKD1L1 PKD1L2 PKD1

3.74e-0641843IPR014010
DomainWD40_repeat_CS

WDR5B COP1 PIK3R4 FBXW8 NWD2 GTF3C2 CDC40 KCTD3 HERC1 TBL1X

5.34e-0616418410IPR019775
DomainGLYCOSYL_HYDROL_F1_1

LCT GBA3 KL

9.27e-0651843PS00572
DomainGlyco_hydro_1

LCT GBA3 KL

9.27e-0651843PF00232
DomainGLYCOSYL_HYDROL_F1_2

LCT GBA3 KL

9.27e-0651843PS00653
DomainGlyco_hydro_1

LCT GBA3 KL

9.27e-0651843IPR001360
DomainGlycoside_hydrolase_SF

GALC MANBA LCT GBA3 KL HYAL2

1.32e-05531846IPR017853
DomainPKD/REJ-like

PKD1L1 PKD1L2 PKD1

1.84e-0561843IPR002859
DomainREJ

PKD1L1 PKD1L2 PKD1

1.84e-0561843PF02010
Domain-

GALC MANBA LCT GBA3 KL

2.24e-053518453.20.20.80
DomainIntegrin_alpha-2

ITGA11 ITGA2B ITGAE ITGAM

2.50e-05181844IPR013649
DomainLH2

PKD1L1 PKD1L2 LOXHD1 PKD1

2.50e-05181844SM00308
DomainINTEGRIN_ALPHA

ITGA11 ITGA2B ITGAE ITGAM

2.50e-05181844PS00242
DomainIntegrin_alpha2

ITGA11 ITGA2B ITGAE ITGAM

2.50e-05181844PF08441
DomainIntegrin_alpha

ITGA11 ITGA2B ITGAE ITGAM

2.50e-05181844IPR000413
DomainInt_alpha

ITGA11 ITGA2B ITGAE ITGAM

3.15e-05191844SM00191
DomainInt_alpha_beta-p

ITGA11 ITGA2B ITGAE ITGAM

3.15e-05191844IPR013519
DomainGlyco_hydro_catalytic_dom

GALC MANBA LCT GBA3 KL

3.39e-05381845IPR013781
DomainRCC1

HERC2 HERC1 HERC4 HERC5

3.90e-05201844PF00415
Domain-

PKD1L1 PKD1L2 LOXHD1 PKD1

4.79e-052118442.60.60.20
DomainPLAT

PKD1L1 PKD1L2 LOXHD1 PKD1

4.79e-05211844PF01477
DomainPLAT/LH2_dom

PKD1L1 PKD1L2 LOXHD1 PKD1

4.79e-05211844IPR001024
DomainPLAT

PKD1L1 PKD1L2 LOXHD1 PKD1

4.79e-05211844PS50095
DomainRCC1_1

HERC2 HERC1 HERC4 HERC5

4.79e-05211844PS00625
DomainRCC1_2

HERC2 HERC1 HERC4 HERC5

4.79e-05211844PS00626
DomainRCC1_3

HERC2 HERC1 HERC4 HERC5

4.79e-05211844PS50012
DomainGDA1_CD39_NTPase

ENTPD1 ENTPD3 ENTPD8

5.08e-0581843IPR000407
DomainGDA1_CD39

ENTPD1 ENTPD3 ENTPD8

5.08e-0581843PF01150
DomainGDA1_CD39_NTPASE

ENTPD1 ENTPD3 ENTPD8

5.08e-0581843PS01238
Domain-

HERC2 HERC1 HERC4 HERC5

5.80e-052218442.130.10.30
DomainFG_GAP

ITGA11 ITGA2B ITGAE ITGAM

5.80e-05221844PS51470
DomainReg_chr_condens

HERC2 HERC1 HERC4 HERC5

5.80e-05221844IPR000408
DomainRCC1/BLIP-II

HERC2 HERC1 HERC4 HERC5

6.97e-05231844IPR009091
DomainFG-GAP

ITGA11 ITGA2B ITGAE ITGAM

8.30e-05241844PF01839
DomainFG-GAP

ITGA11 ITGA2B ITGAE ITGAM

8.30e-05241844IPR013517
DomainPEP_carboxykin_GTP_CS

PCK1 PCK2

9.65e-0521842IPR018091
DomainPEPCK

PCK1 PCK2

9.65e-0521842PF00821
DomainPEP_carboxykinase_GTP

PCK1 PCK2

9.65e-0521842IPR008209
DomainPEPCK_GTP

PCK1 PCK2

9.65e-0521842PS00505
DomainPEP_carboxykinase_N

PCK1 PCK2

9.65e-0521842IPR008210
DomainPEP_carboxykinase_C

PCK1 PCK2

9.65e-0521842IPR013035
Domain-

PCK1 PCK2

9.65e-05218423.90.228.20
Domain-

PCK1 PCK2

9.65e-05218423.40.449.10
DomainIntegrin_dom

ITGA11 ITGA2B ITGAE ITGAM

9.81e-05251844IPR032695
DomainHECT

HERC2 HERC1 HERC4 HERC5

1.34e-04271844PF00632
DomainHECTc

HERC2 HERC1 HERC4 HERC5

1.34e-04271844SM00119
DomainHECT_dom

HERC2 HERC1 HERC4 HERC5

1.34e-04271844IPR000569
DomainHECT

HERC2 HERC1 HERC4 HERC5

1.34e-04271844PS50237
DomainIntegrin_alpha

ITGA2B ITGAE ITGAM

1.46e-04111843PF00357
DomainPKD_channel

PKD1L1 PKD1L2 PKD1

1.46e-04111843PF08016
DomainPKD1_2_channel

PKD1L1 PKD1L2 PKD1

1.46e-04111843IPR013122
DomainVWFA

ITGA11 COL20A1 ITGAE ITGAM ITIH4 HMCN2

1.59e-04821846PS50234
DomainVWA

ITGA11 COL20A1 ITGAE ITGAM ITIH4 HMCN2

1.81e-04841846SM00327
DomainSSF

SLC5A10 SLC5A7 SLC5A8

1.94e-04121843PF00474
DomainNA_SOLUT_SYMP_2

SLC5A10 SLC5A7 SLC5A8

1.94e-04121843PS00457
DomainNa/solute_symporter

SLC5A10 SLC5A7 SLC5A8

1.94e-04121843IPR001734
DomainNA_SOLUT_SYMP_3

SLC5A10 SLC5A7 SLC5A8

1.94e-04121843PS50283
DomainVWA

ITGA11 COL20A1 ITGAE ITGAM ITIH4

2.23e-04561845PF00092
DomainAdaptor_Cbl_EF_hand-like

CBLC CBL

2.88e-0431842IPR014741
DomainAdaptor_Cbl_SH2-like

CBLC CBL

2.88e-0431842IPR014742
DomainAdaptor_Cbl

CBLC CBL

2.88e-0431842IPR024162
DomainCbl_PTB

CBLC CBL

2.88e-0431842IPR024159
DomainCbl_N2

CBLC CBL

2.88e-0431842PF02761
DomainCbl_N3

CBLC CBL

2.88e-0431842PF02762
DomainCbl_N

CBLC CBL

2.88e-0431842PF02262
DomainAdaptor_Cbl_N_hlx

CBLC CBL

2.88e-0431842IPR003153
DomainCBL_PTB

CBLC CBL

2.88e-0431842PS51506
Domain-

CBLC CBL

2.88e-04318421.20.930.20
DomainGPS

PKD1L1 ADGRL1 PKD1L2 PKD1

4.20e-04361844PS50221
DomainVWF_A

ITGA11 COL20A1 ITGAE ITGAM ITIH4 HMCN2

4.42e-04991846IPR002035
DomainGPS

PKD1L1 ADGRL1 PKD1L2 PKD1

4.67e-04371844IPR000203
DomainIntegrin_alpha_C_CS

ITGA2B ITGAE ITGAM

4.79e-04161843IPR018184
DomainAmidase_domain

PGLYRP4 PGLYRP1

5.72e-0441842IPR002502
DomainPGRP

PGLYRP4 PGLYRP1

5.72e-0441842SM00701
DomainAmidase_2

PGLYRP4 PGLYRP1

5.72e-0441842PF01510
DomainAmi_2

PGLYRP4 PGLYRP1

5.72e-0441842SM00644
Domain-

PGLYRP4 PGLYRP1

5.72e-04418423.40.80.10
DomainPGRP_domain_met/bac

PGLYRP4 PGLYRP1

5.72e-0441842IPR006619
DomainPGRP

PGLYRP4 PGLYRP1

5.72e-0441842IPR015510
DomainPA

TFRC SPPL2A SPPL2C

8.11e-04191843PF02225
DomainPA_domain

TFRC SPPL2A SPPL2C

8.11e-04191843IPR003137
DomainAnaphylatoxin_comp_syst

C4A C4B

9.47e-0451842IPR018081
DomainAnaphylatoxn_comp_syst_dom

C4A C4B

9.47e-0451842IPR001840
DomainPeptidase_A22B_SPP

SPPL2A SPPL2C

9.47e-0451842IPR007369
DomainGal_Lectin

ADGRL1 PKD1L2

9.47e-0451842PF02140
DomainLectin_gal-bd_dom

ADGRL1 PKD1L2

9.47e-0451842IPR000922
DomainSUEL_LECTIN

ADGRL1 PKD1L2

9.47e-0451842PS50228
DomainDMAP_binding

DIP2A DIP2C

9.47e-0451842PF06464
PathwayREACTOME_PHOSPHATE_BOND_HYDROLYSIS_BY_NTPDASE_PROTEINS

ENTPD1 ENTPD3 ENTPD8

4.96e-0581383M27737
PathwayREACTOME_PHOSPHATE_BOND_HYDROLYSIS_BY_NTPDASE_PROTEINS

ENTPD1 ENTPD3 ENTPD8

4.96e-0581383MM15486
PathwayKEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS

SOCS3 COP1 CBLC CBL FBXW8 HERC2 HERC1 HERC4

5.37e-051351388M15247
PathwayPID_INTEGRIN_CS_PATHWAY

ITGA11 ITGA2B ITGAE ITGAM

1.11e-04261384M47
PathwayREACTOME_GLUCONEOGENESIS

SLC37A1 GAPDH PCK1 PCK2

1.11e-04261384M13748
PathwayREACTOME_GLUCONEOGENESIS

SLC37A1 GAPDH PCK1 PCK2

1.11e-04261384MM15392
Pubmed

Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8.

ENTPD1 ENTPD3 ENTPD8

6.29e-074189318404504
Pubmed

Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists.

ENTPD1 ENTPD3 ENTPD8

6.29e-074189317727821
Pubmed

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

TRPM6 TRPM4 PKD1L1 PKD1L2 PKD1

9.43e-0733189519834762
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

SHANK1 RALGAPA1 GAPDH MYO9A ACO2 RAPGEF4 ADGRL1 CCT7 BCAN ARF4 ARF5 PIK3R4 DIP2A NWD2 AP1G1 SCAMP5 TRAPPC10 C4A TNKS1BP1 C4B DYNC1I1 ALDH7A1 SEC13 KPNA3

1.03e-0614311892437142655
Pubmed

A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis.

ITGAM C4A C4B

1.57e-06518939382884
Pubmed

The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects.

HERC1 HERC4 HERC5

1.57e-065189315676274
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TRPM4 CRYBG2 RAPGEF6 SOCS3 KDM3B IPP CBLC ADGRL1 LRRK1 GBA2 LPIN3 DIP2A TULP4 PKD1 DIP2C TNKS1BP1 HERC2 HERC1 RIC1 KLHL17

2.84e-0611051892035748872
Pubmed

Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation.

CBLC CBL PIK3R4 PIK3R1

3.07e-0619189431959764
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

ZNF609 RAPGEF6 OBSL1 KDM3B PIK3R4 LPIN3 DIP2A CDC40 AP1G1 TSR1 TLL1 BUB1B C4A C4B RIC1

3.07e-066501891538777146
Pubmed

Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H.

CFHR4 C4A C4B

3.12e-066189316849499
Pubmed

cbl-b inhibits epidermal growth factor receptor signaling.

CBLC CBL PIK3R1

3.12e-066189310086340
Pubmed

Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.

GAPDH ACO2 LCT PGD PCK1 PCK2 ALDH7A1

3.16e-06114189728245920
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

POLR2B RAPGEF4 TGM5 PIK3R4 DIP2A LOXHD1 PTPRB GRID2IP HPR C4A C4B HERC1 RIC1

3.75e-064971891336774506
Pubmed

Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.

TRPM6 TRPM4 PKD1L1 PKD1L2 PKD1

4.11e-0644189519322198
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

GABRD SLC37A1 TRPM4 NPTX1 CENPB GAPDH ACO2 OBSL1 BACE1 TCTA SLC45A4 TRAP1 PKD1 HERC2 SEC13

7.10e-066971891528298427
Pubmed

C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens.

ITGAM C4A C4B

8.67e-068189324474777
Pubmed

Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.

LRRK1 TG DUOX1 KL

1.15e-0526189433905568
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

FKBP15 P4HA2 ZNF609 GALC DYNC2I2 CENPB OBSL1 DGKE RABL3 LPIN3 ACSL3 TRAP1 NPHP3 GTF3C2 PIK3R1 KCTD3 TRAPPC10 TNKS1BP1 IFT80 PCK2 KPNA3

1.16e-0513211892127173435
Pubmed

TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin.

GAPDH CBL PIK3R1

1.30e-059189315107835
Pubmed

Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.

ITGA11 ITGA2B ITGAE ITGAM

1.34e-0527189431541017
Pubmed

Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells.

PKD1L1 PKD1L2 PKD1

1.84e-0510189316805797
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

CHL1 ICOSLG SLC5A10 PGLYRP1 GAPDH ITGAM PGD PLBD2 ITIH4 ARF5 KL SPPL2A HPR C4A C4B LRRN4 SLC5A8 ALDH7A1

2.42e-0510701891823533145
Pubmed

Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke.

BCAN CRYBG1 KCNK17

2.52e-0511189319910543
Pubmed

Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis.

CFHR4 C4A C4B

2.52e-0511189323204401
Pubmed

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.

RALGAPA1 NPTX1 DYNC2I2 MYO9A ADGRL1 DGKE ACSL3 NWD2 KCTD3 TRAPPC10 HERC2

2.60e-054301891132581705
Pubmed

Polycystin-1L2 is a novel G-protein-binding protein.

PKD1L1 PKD1L2

2.94e-052189215203210
Pubmed

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.

C4A C4B

2.94e-052189222737222
Pubmed

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

C4A C4B

2.94e-052189216565498
Pubmed

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

C4A C4B

2.94e-052189215998580
Pubmed

High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.

C4A C4B

2.94e-052189219062096
Pubmed

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

C4A C4B

2.94e-052189219933335
Pubmed

Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

C4A C4B

2.94e-05218922459207
Pubmed

Antigen-induced B cell apoptosis is independent of complement C4.

C4A C4B

2.94e-052189217645767
Pubmed

Anti-DNA autoreactivity in C4-deficient mice.

C4A C4B

2.94e-052189212207352
Pubmed

Cloning, genomic organization and expression pattern of a novel Drosophila gene, the disco-interacting protein 2 (dip2), and its murine homolog.

DIP2A DIP2C

2.94e-052189212137943
Pubmed

CBL mutations in myeloproliferative neoplasms are also found in the gene's proline-rich domain and in patients with the V617FJAK2.

CBLC CBL

2.94e-052189222315494
Pubmed

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

C4A C4B

2.94e-052189227758680
Pubmed

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

C4A C4B

2.94e-052189222387014
Pubmed

CD38-mediated growth suppression of B-cell progenitors requires activation of phosphatidylinositol 3-kinase and involves its association with the protein product of the c-cbl proto-oncogene.

CBL PIK3R1

2.94e-05218928695807
Pubmed

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.

C4A C4B

2.94e-052189223749435
Pubmed

Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.

C4A C4B

2.94e-052189223918728
Pubmed

Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.

C4A C4B

2.94e-05218923037333
Pubmed

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

C4A C4B

2.94e-052189211726230
Pubmed

Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.

C4A C4B

2.94e-05218924216347
Pubmed

Sequence determination of the thiolester site of the fourth component of human complement.

C4A C4B

2.94e-05218926950384
Pubmed

Dysregulation of phosphoenolpyruvate carboxykinase in cancers: A comprehensive analysis.

PCK1 PCK2

2.94e-052189238697449
Pubmed

Mouse CD11bhigh lung dendritic cells have more potent capability to induce IgA than CD103+ lung dendritic cells in vitro.

ITGAE ITGAM

2.94e-052189222268142
Pubmed

Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.

C4A C4B

2.94e-05218928660986
Pubmed

Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.

C4A C4B

2.94e-05218928428773
Pubmed

Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans.

LCT GBA3

2.94e-052189212594539
Pubmed

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.

C4A C4B

2.94e-052189224638111
Pubmed

Transcriptional repression of C4 complement by hepatitis C virus proteins.

C4A C4B

2.94e-052189221345967
Pubmed

Role of phosphoinositide 3-kinase and the Cbl adaptor protein in coupling the alpha4beta1 integrin to mitogen-activated protein kinase signalling.

CBL PIK3R1

2.94e-052189210620516
Pubmed

Assignment of CD163B, the gene encoding M160, a novel scavenger receptor, to human chromosome 12p13.3 by in situ hybridization and somatic cell hybrid analysis.

CD163 CD163L1

2.94e-052189211124526
Pubmed

c-Cbl is tyrosine-phosphorylated by interleukin-4 and enhances mitogenic and survival signals of interleukin-4 receptor by linking with the phosphatidylinositol 3'-kinase pathway.

CBL PIK3R1

2.94e-05218929414268
Pubmed

Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.

C4A C4B

2.94e-05218922572548
Pubmed

The complement component C4 of mammals.

C4A C4B

2.94e-05218922302180
Pubmed

Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis.

KL C9orf72

2.94e-052189232887666
Pubmed

Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early Phase of the Accelerated Rotarod Task.

CNTNAP3B CNTNAP3

2.94e-052189226807827
Pubmed

Association of a polymorphism in the gene encoding phosphoenolpyruvate carboxykinase 1 with high-density lipoprotein and triglyceride levels.

PCK1 PCK2

2.94e-052189216132948
Pubmed

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

C4A C4B

2.94e-052189222151770
Pubmed

C4d-positive chronic rejection: a frequent entity with a poor outcome.

C4A C4B

2.94e-052189218091514
Pubmed

Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.

C4A C4B

2.94e-052189229080553
Pubmed

Ras-dependent, Ca2+-stimulated activation of nuclear factor of activated T cells by a constitutively active Cbl mutant in T cells.

CBL PIK3R1

2.94e-05218928995243
Pubmed

Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.

C4A C4B

2.94e-05218926589636
Pubmed

C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.

C4A C4B

2.94e-052189225339671
Pubmed

A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.

C4A C4B

2.94e-052189217728371
Pubmed

Structure and organization of the C4 genes.

C4A C4B

2.94e-05218926149580
Pubmed

Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.

C4A C4B

2.94e-05218926149581
Pubmed

The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.

C4A C4B

2.94e-052189212115608
Pubmed

Biochemistry and biology of anaphylatoxins.

C4A C4B

2.94e-05218923542363
Pubmed

C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.

C4A C4B

2.94e-05218922387317
Pubmed

Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.

C4A C4B

2.94e-052189216908004
Pubmed

Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.

C4A C4B

2.94e-05218927365238
Pubmed

Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.

C4A C4B

2.94e-05218927391573
Pubmed

Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.

C4A C4B

2.94e-052189217971360
Pubmed

Clinical features of patients with homozygous complement C4A or C4B deficiency.

C4A C4B

2.94e-052189229928053
Pubmed

Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.

C4A C4B

2.94e-052189217971229
Pubmed

Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.

C4A C4B

2.94e-05218926881182
Pubmed

Shp-2 mediates v-Src-induced morphological changes and activation of the anti-apoptotic protein kinase Akt.

CBL PIK3R1

2.94e-052189210918571
Pubmed

The protein product of the proto-oncogene c-cbl forms a complex with phosphatidylinositol 3-kinase p85 and CD19 in anti-IgM-stimulated human B-lymphoma cells.

CBL PIK3R1

2.94e-05218928896416
Pubmed

Partial C4 deficiency in juvenile idiopathic arthritis patients.

C4A C4B

2.94e-052189217921792
Pubmed

Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.

C4A C4B

2.94e-052189221880985
Pubmed

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors.

ITGAE ENTPD1

2.94e-052189230006565
Pubmed

Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.

C4A C4B

2.94e-05218926978711
Pubmed

Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.

C4A C4B

2.94e-052189235898513
Pubmed

Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.

C4A C4B

2.94e-052189228873507
Pubmed

c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway.

CBL PIK3R1

2.94e-052189220133944
Pubmed

Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.

C4A C4B

2.94e-0521892276882
Pubmed

Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.

C4A C4B

2.94e-05218926832377
Pubmed

Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.

C4A C4B

2.94e-05218923794341
Pubmed

Cystic fibrosis remodels the regulation of purinergic signaling by NTPDase1 (CD39) and NTPDase3.

ENTPD1 ENTPD3

2.94e-052189220190036
Pubmed

CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden.

ITGAE ENTPD1

2.94e-052189236792124
Pubmed

Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.

C4A C4B

2.94e-052189222785613
Pubmed

Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.

C4A C4B

2.94e-052189232691186
Pubmed

Molecular cloning and expression of a novel klotho-related protein.

GBA3 KL

2.94e-052189211043382
Pubmed

The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.

C4A C4B

2.94e-05218928390682
Pubmed

Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).

C4A C4B

2.94e-05218923902619
Pubmed

Structural polymorphism of murine C4 and its linkage to H-2.

C4A C4B

2.94e-05218927373044
Pubmed

The chemical structure of the C4d fragment of the human complement component C4.

C4A C4B

2.94e-05218923696167
InteractionCCT2 interactions

P4HA2 PLB1 WDR5B DYNC2I2 GAPDH OBSL1 COP1 CCT7 LRRK1 ITGA2B PIK3R4 GBA3 FBXW8 CDC40 TSR1 HPR BUB1B C9orf72 PCK1 DYNC1I1

3.18e-0666618420int:CCT2
InteractionDNAJC7 interactions

GAPDH POLR2B OBSL1 PGD DIP2A GTF3C2 RSPH1 BUB1B FUNDC2 PLD5 HERC2 C9orf72 HERC4 DYNC1I1 HERC5

8.83e-0642518415int:DNAJC7
Cytoband21q22.3

SLC37A1 ICOSLG DIP2A RSPH1 TRAPPC10

1.97e-04128189521q22.3
Cytoband12p13.3

CD163 SLC6A13 CD163L1

2.57e-0430189312p13.3
GeneFamilyWD repeat domain containing

WDR64 WDR5B DYNC2I2 COP1 PIK3R4 FBXW8 GTF3C2 CDC40 TULP4 TLE6 IFT80 CFAP57 HERC1 DYNC1I1 TBL1X SEC13

4.65e-1126212716362
GeneFamilyCD molecules|Integrin alpha subunits

ITGA11 ITGA2B ITGAE ITGAM

6.58e-061812741160
GeneFamilyComplement system|Sushi domain containing

ITGAM CFHR4 C4A C4B

1.15e-04361274492
GeneFamilyBeta-gamma crystallin domain containing

CRYBG2 CRYBG1

1.46e-04312721360
GeneFamilySolute carriers

SLC37A1 SLC5A10 SLC5A7 SLC35G6 SLC45A4 SLC6A9 SLC6A13 SLC35G3 SLC16A14 SLC5A8

4.78e-0439512710752
GeneFamilyLong pentraxins

NPTX1 NPTXR

4.83e-04512721142
GeneFamilyFibronectin type III domain containing

CHL1 COL20A1 INSRR CMYA5 PTPRB LRRN4

9.37e-041601276555
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

C4A C4B

1.71e-03912721234
GeneFamilyADAM metallopeptidase domain containing|CD molecules

ICOSLG ITGA2B ITGAE ITGAM CD163 TFRC CD1D CD101 ENTPD1

1.87e-033941279471
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

BCAN PKD1L2 PKD1

2.97e-034112731298
GeneFamilyKelch like|BTB domain containing

IPP KLHL32 KLHL17

3.18e-03421273617
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder mesenchyme_emap-3087_k-means-cluster#2_top-relative-expression-ranked_500

RERG P4HA2 WNT2 RAPGEF4 SOCS3 RYR2 BUB1B PCK2

1.70e-051291848gudmap_developingLowerUrinaryTract_e13.5_bladder mesenchyme_500_k2
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder mesenchyme_emap-3087_top-relative-expression-ranked_500

GABRB1 CHL1 RERG P4HA2 WNT2 RAPGEF4 SOCS3 ANGPTL1 RYR2 PTPRB ENTPD1 BUB1B LRRN4 PCK2

1.89e-0542018414gudmap_developingLowerUrinaryTract_e13.5_bladder mesenchyme_500
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

TRPM6 HDAC9 CNTNAP3B ACR RAPGEF4 CNTNAP3 HIF3A PTPRB TLL1 ENTPD1 HYAL2

3.41e-101801891127e8bbee388e64dd79d70b160b76d45b1f398006
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HDAC9 CNTNAP3B RAPGEF4 CNTNAP3 HIF3A PKHD1L1 PTPRB TLL1 ENTPD1 FGF6 HYAL2

9.91e-10199189113a4deea6e11a0555d27497b7c9983350797aac69
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Bronchial_vessel|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

HDAC9 CNTNAP3B RAPGEF4 SOCS3 HIF3A PKHD1L1 PTPRB TLL1 ENTPD1 HYAL2

1.45e-081991891053b6a661d381b1ed3ea96e61e8bd1750de7d9fda
ToppCellParenchyma_Control_(B.)-Endothelial-TX-Bronchial_vessel|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

HDAC9 CNTNAP3B RAPGEF4 SOCS3 HIF3A PKHD1L1 PTPRB TLL1 ENTPD1 HYAL2

1.45e-08199189109c753043024871b1f1436fc39defac4da85e10cd
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Bronchial_vessel-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HDAC9 CNTNAP3B RAPGEF4 SOCS3 HIF3A PKHD1L1 PTPRB TLL1 ENTPD1 HYAL2

1.45e-0819918910d017dd91f9b10038f1f83753a766e534da2dbe89
ToppCellAdult-Endothelial-endothelial_cell_of_vein|Adult / Lineage, Cell type, age group and donor

HDAC9 CNTNAP3B ACR RAPGEF4 HIF3A PKHD1L1 PTPRB TLL1 HYAL2

6.68e-081761899043683c61c5d1a7f8a4666a612310246bd3d83a2
ToppCellControl-Endothelial_cells-Pulmonary_venous_endothelial_cells|Control / group, cell type (main and fine annotations)

HDAC9 CNTNAP3B RAPGEF4 HIF3A PKHD1L1 PTPRB TLL1 ENTPD1 HYAL2

9.33e-08183189946be9f96755c7b65aeac061d95d15abeb6466034
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein|Children_(3_yrs) / Lineage, Cell type, age group and donor

TRPM6 HDAC9 CNTNAP3B RAPGEF4 CNTNAP3 HIF3A PTPRB TLL1 ENTPD1

1.12e-071871899e35716f8b482be3bf5ab79f087a9caf67a9d197a
ToppCellPND07-28-samps-Mesenchymal-Mesenchymal_stem_cell|PND07-28-samps / Age Group, Lineage, Cell class and subclass

SHANK1 HDAC9 RAPGEF4 INSRR ITGAM GIPR DUOX1 KL

1.32e-071371898ed81624b9167255ce88dcf6ad7f1636376ea0525
ToppCellPND07-28-samps-Mesenchymal-Mesenchymal_stem_cell-Mesenchymal_fibroblast|PND07-28-samps / Age Group, Lineage, Cell class and subclass

SHANK1 HDAC9 RAPGEF4 INSRR ITGAM GIPR DUOX1 KL

1.32e-07137189847859aa25f32367461c1ec75ed9060bee430c6b7
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HDAC9 PLB1 LRRK1 ITGAM SFMBT2 CD163 CD163L1 ENTPD1 LOXL3

1.34e-071911899baa70781633a3fe5bf987f9d8dff3884f5167e7f
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

HDAC9 CNTNAP3B RAPGEF4 HIF3A PKHD1L1 PTPRB TLL1 ENTPD1 HYAL2

1.47e-0719318999ba688b35a9ead5d04691b3f3f15484f02dbbd0d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

HDAC9 CNTNAP3B RAPGEF4 HIF3A PKHD1L1 PTPRB TLL1 ENTPD1 HYAL2

1.47e-071931899287e756d5fd3bd2931c168da24beaa0d02a350ae
ToppCellEndothelial-endothelial_cell_of_vein|World / Lineage, Cell type, age group and donor

HDAC9 CNTNAP3B RAPGEF4 DGKE HIF3A PTPRB TLL1 ENTPD1 HYAL2

1.53e-0719418993cbd9622a68e89add90e589867d88c83c5a33476
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HDAC9 PLB1 LRRK1 ITGAM SFMBT2 CD163 CD163L1 ENTPD1 LOXL3

1.60e-07195189934a9462f4e843f3065cc58c17ad71c1b5b836ae1
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HDAC9 CNTNAP3B RAPGEF4 HIF3A PKHD1L1 PTPRB TLL1 ENTPD1 HYAL2

1.75e-071971899b0036cf3f7e6edf8e43f16cd2f0f0e80471d2576
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_bronchial_vessel|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

HDAC9 CNTNAP3B ACR RAPGEF4 DGKE PTPRB SLC16A14 CD101

2.15e-071461898df865558d1843f3857ebd1529cebc540d3554c59
ToppCellAdult-Endothelial-endothelial_cell_of_vein-D122|Adult / Lineage, Cell type, age group and donor

ACR RAPGEF4 HIF3A PKHD1L1 PTPRB NPTXR TLL1 HYAL2

4.32e-0716018980cfe130606af433b2aa90e0a20b6c44659dd6fd4
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

TRPM6 HDAC9 CNTNAP3B RAPGEF4 CNTNAP3 HIF3A PTPRB TLL1

5.99e-071671898d7fe24cdc4b55a9555ce9e20699f5036b88148e9
ToppCelldroplet-Heart-HEART-1m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PGLYRP1 WNT2 ACR PKHD1L1 SFMBT2 ACSL3 TLL1 ZG16

7.82e-0717318989dc7746a84f0e268a7c061e1bbcd5e31903034dc
ToppCellPCW_13-14-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CHL1 CNTNAP3B CNTNAP3 SLC45A4 KL PTPRB ENTPD1 CRYBG1

9.69e-071781898c227da59dc7beb73f84405bf13356bdeb59d9338
ToppCellwk_15-18-Mesenchymal-Mesothelial-intermediate_mesothelial|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

DSPP PKHD1L1 TGM5 TG SLC6A13 C4A LRRN4 MUCL3

1.01e-061791898b1f085e4c8d65d5cdbfaf2db80343638abb08979
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PGLYRP1 WNT2 PKHD1L1 PTPRB TLL1 ENTPD1 PLD5 HYAL2

1.10e-061811898cef034030e6b029a49ae56be37ea1fac1a5c350e
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

HDAC9 CNTNAP3B RAPGEF4 DGKE PTPRB TLL1 ENTPD1 HYAL2

1.10e-0618118982c660fcf0404c155955b67ab2958d6e6b0e30024
ToppCellCOVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

HDAC9 CNTNAP3B RAPGEF4 HIF3A PKHD1L1 PTPRB TLL1 HYAL2

1.40e-0618718982d20193a6cacdfa4877457c97b0077408942186c
ToppCellCOVID-19-lung-Vein_EC|lung / Disease (COVID-19 only), tissue and cell type

HDAC9 CNTNAP3B RAPGEF4 PKHD1L1 PTPRB TLL1 ENTPD1 HYAL2

1.46e-061881898d582b76fc2faac526c9bf97503041129e1a6a211
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel|Children_(3_yrs) / Lineage, Cell type, age group and donor

CNTNAP3B RAPGEF4 CNTNAP3 HIF3A PKHD1L1 PTPRB TLL1 DYNC1I1

1.46e-061881898c2805232618a7b6f844d34e37ad458a9923dbfe1
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CNTNAP3B RAPGEF4 CNTNAP3 HIF3A PTPRB HMCN2 SLC16A14 ENTPD1

1.52e-0618918986463890d8dbee4bc198f91628a5f784970de786a
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CNTNAP3B RAPGEF4 CNTNAP3 HIF3A PKHD1L1 PTPRB TLL1 DYNC1I1

1.58e-0619018986e6ce6dd549d1c38cfef5b3f8be06ab01ce344b7
ToppCellCOVID-19-lung-Vein_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

HDAC9 CNTNAP3B RAPGEF4 PKHD1L1 PTPRB TLL1 ENTPD1 HYAL2

1.58e-0619018981caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HDAC9 PLB1 LRRK1 ITGAM SFMBT2 CD163 CD163L1 LOXL3

1.58e-061901898788ff9d8888d2dd25b7e1d7e0e5d57751ce86f19
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel|Adult / Lineage, Cell type, age group and donor

CNTNAP3B RAPGEF4 CNTNAP3 HIF3A PKHD1L1 PTPRB TLL1 DYNC1I1

1.58e-06190189891bf3b7e9148589757436a53a4f58e0ebfe54400
ToppCell3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HDAC9 RAPGEF4 SOCS3 HIF3A PKHD1L1 PTPRB ENTPD1 HYAL2

1.78e-061931898682ce63b73a7d02eef240673db67058d7507f744
ToppCell3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HDAC9 RAPGEF4 SOCS3 HIF3A PKHD1L1 PTPRB ENTPD1 HYAL2

1.78e-061931898c0f0052c24b7fe9e21d2bc6c38047a8e755f87b6
ToppCellnucseq-Endothelial-Endothelial_Lymphatic-LEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CNTNAP3B CNTNAP3 HIF3A PKHD1L1 PTPRB TLL1 DYNC1I1 HYAL2

1.85e-061941898f772a9f9ef8635aeaeb8b022dbb94e9672b36ead
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HDAC9 PLB1 LRRK1 ITGAM SFMBT2 CD163 CD163L1 LOXL3

1.85e-0619418981dce6d4b6ac41f80677e3e4c335a4f383bd76f85
ToppCellnucseq-Endothelial-Endothelial_Lymphatic-LEC-LEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CNTNAP3B CNTNAP3 HIF3A PKHD1L1 PTPRB TLL1 DYNC1I1 HYAL2

1.85e-0619418983b73f2d305a7566f7ab567e5f18c82cd3d80e32c
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

HDAC9 CNTNAP3B RAPGEF4 DGKE PTPRB TLL1 ENTPD1 HYAL2

1.85e-061941898fc2e0081005c0c496e41197a2d06e4a37708221f
ToppCellnucseq-Endothelial-Endothelial_Lymphatic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CNTNAP3B CNTNAP3 HIF3A PKHD1L1 PTPRB TLL1 DYNC1I1 HYAL2

1.85e-0619418985d2b3ed5374e2ab10c1c7eb3a03139fc95036a48
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CNTNAP3B HIF3A PTPRB HMCN2 SLC16A14 ENTPD1 PLD5 HYAL2

1.92e-0619518986bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HDAC9 CNTNAP3B RAPGEF4 DGKE HIF3A PKHD1L1 PTPRB TLL1

1.92e-06195189881a98ebb0d43f416f9a8bba580531dc0cfea8f74
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CNTNAP3B RAPGEF4 HIF3A PKHD1L1 PTPRB TLL1 ENTPD1 HYAL2

1.99e-06196189822767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCellAdult-Immune-monocyte-D122|Adult / Lineage, Cell type, age group and donor

HDAC9 PLB1 MANBA ITGAM CD163 CD1D ENTPD1 LOXL3

1.99e-06196189816b0acb6157534938ca83d4e909471e33a7d3c52
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HDAC9 PLB1 LRRK1 ITGAM CD163 CD163L1 ENTPD1 LOXL3

1.99e-0619618984370473693d2dd4a8c451a4c477eb79baa33ae12
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CNTNAP3B ACR RAPGEF4 SOCS3 PKHD1L1 PTPRB SLC35G3 HYAL2

2.07e-0619718981a137af40697137bb9d2b5caf2b1ffda55f04461
ToppCellParenchyma_Control_(B.)-Endothelial-TX-Endothelial-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

CNTNAP3B ACR RAPGEF4 SOCS3 PKHD1L1 PTPRB SLC35G3 HYAL2

2.07e-061971898f969685dee212f33a6f09e54c0cd1fd24ffef546
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CNTNAP3B ACR RAPGEF4 SOCS3 PKHD1L1 PTPRB SLC35G3 HYAL2

2.07e-06197189896d63a8d00583e2aa0a38412e2ae27e23f399493
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HDAC9 RAPGEF4 SOCS3 HIF3A PKHD1L1 PTPRB ENTPD1 HYAL2

2.15e-0619818983ae1e2b4ca77b94eaa24a8c990780aff47dface6
ToppCellBronchial-NucSeq-Endothelial-Endothelia_lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CNTNAP3B CNTNAP3 HIF3A PKHD1L1 LOXHD1 PTPRB TLL1 DYNC1I1

2.15e-061981898fc4b7c3ad52bc5c8b40fa04a156bfbb58afa2872
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HDAC9 RAPGEF4 SOCS3 HIF3A PKHD1L1 PTPRB ENTPD1 HYAL2

2.15e-06198189871ee440b1ac566db63d0b415c50a0ad064d14f15
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HDAC9 PLB1 LRRK1 ITGAM SFMBT2 CD163 CD163L1 ENTPD1

2.15e-06198189896883ad8e189a46ed5b7eaafc0543e53682d26ed
ToppCellBronchial-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CNTNAP3B CNTNAP3 HIF3A PKHD1L1 LOXHD1 PTPRB TLL1 DYNC1I1

2.15e-061981898b3a020522e064bb61949d38e442f24026e339364
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HDAC9 RAPGEF4 SOCS3 HIF3A PKHD1L1 PTPRB ENTPD1 HYAL2

2.15e-061981898fb70a649e4e2edb32967328c1085dc5999c29a33
ToppCellPND07-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PGLYRP1 LCT ITGAM PGD SLC6A13 LOXHD1 CD101

2.32e-06140189790298cac4bcec614a48e60b5c139c86daa9f0321
ToppCellPND07-Immune-Immune_Myeloid-Granulocytic-Neutrophil|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PGLYRP1 LCT ITGAM PGD SLC6A13 LOXHD1 CD101

2.32e-061401897671ab1f5cbd8568bf93ebdf961c2a1ede06d2bcb
ToppCellPBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TRPM6 CNTNAP3B NPTX1 PGLYRP1 CNTNAP3 SLC45A4 PTPRB

2.55e-061421897191a13bba143ecdfc2bfd797c3ac191481388298
ToppCellPBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TRPM6 CNTNAP3B NPTX1 PGLYRP1 CNTNAP3 SLC45A4 PTPRB

2.67e-061431897b405dba9a83a99cc7b53ce71772bc52a0bbb0d4e
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_bronchial_vessel-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

HDAC9 CNTNAP3B ACR CNTNAP3 DGKE PTPRB SLC16A14

2.79e-061441897748f4efc59f7afbce6c497524f36d852b8b1d637
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

HDAC9 CNTNAP3B RAPGEF4 SOCS3 DGKE PTPRB TLL1

3.66e-0615018974f31867cb85253ff6d22f3b02ef972a42cb41123
ToppCelldroplet-Lung-LUNG-1m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PGLYRP4 PGLYRP1 LCT PGD SFMBT2 SLC6A13 CD101

5.16e-06158189730cceb73cf5e24b692da84d33342fd3b1ad5efe5
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PGLYRP4 PGLYRP1 LCT PGD SFMBT2 SLC6A13 CD101

5.16e-06158189747793463640f98ee5f680a1ee5786b453355fd57
ToppCelldroplet-Lung-1m-Hematologic-myeloid-neutrophil-neutrophil|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PGLYRP1 ITGAM PGD SLC6A13 CD101 ENTPD1 ENTPD3

5.38e-061591897be54b910ccb73e37eb81945bbad9a89d2bcec34b
ToppCelldroplet-Lung-1m-Hematologic-myeloid-neutrophil|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PGLYRP1 ITGAM PGD SLC6A13 CD101 ENTPD1 ENTPD3

5.38e-061591897178678173b005cb8225472306657f0d8289b133b
ToppCellThalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a7|Thalamus / BrainAtlas - Mouse McCarroll V32

SLC37A1 NPTX1 INSRR SLC5A7 DNAH1 NWD2 TLL1

5.60e-0616018977d34159363d274019e14549d1186c629ce990691
ToppCellThalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a7-Tac2|Thalamus / BrainAtlas - Mouse McCarroll V32

SLC37A1 NPTX1 INSRR SLC5A7 DNAH1 NWD2 TLL1

5.60e-061601897fe5fb0e7a79862f63529721f0a82f4f6d231d3ca
ToppCellfacs-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHANK1 WDR64 MYO9A ITIH4 RYR2 SLC6A9 ZG16

5.84e-061611897b9a17f41426bf715f30bf544a6795afaf37a3aa6
ToppCellfacs-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHANK1 WDR64 MYO9A ITIH4 RYR2 SLC6A9 ZG16

5.84e-061611897f7a89c481f789f624102857be722c95fbeb47595
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HDAC9 ITGA11 RAPGEF4 SLC5A7 TG ATP11C CD200R1L

5.84e-0616118971b805f77790aeb8a71b08bfac2fe2eed7343258f
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ACR SOCS3 PTPRB TLL1 ENTPD1 EDEM2 DYNC1I1

7.71e-06168189732e4d82efaccf336d347e4063253c3635a3ec672
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_IL7R|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRPM4 ITGA11 INSRR FBXW8 NWD2 CD163L1 PLD5

8.33e-0617018976af7dee9b8298d4499e05a82cf9cdfe3bd81d384
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D122|Adult / Lineage, Cell type, age group and donor

CNTNAP3B CNTNAP3 HIF3A PKHD1L1 PTPRB TLL1 DYNC1I1

9.34e-061731897dba09ba9748871e38a16449d500ae4d7b405c42f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_THTPA|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B TRPM4 RERG ITGA11 NWD2 CD163L1 TLL1

1.12e-051781897e4e11e4940c911c17806200c25096928153c684d
ToppCellhuman_hepatoblastoma-Tumor_cells-T6|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

CHL1 HDAC9 CNTNAP3B CNTNAP3 RYR2 ENTPD1 CFAP57

1.17e-05179189714fc8ccb6b215063d747643f47d780d2b237eb67
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHANK1 ZNF609 RYR2 NWD2 TLL1 PLD5 DYNC1I1

1.21e-051801897f6a2208960d0df1500c974cc44c3c054cd7475a9
ToppCell10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8|Liver / Manually curated celltypes from each tissue

RALGAPA1 RAPGEF6 TFRC AP1G1 CRYBG1 HERC1 HERC4

1.25e-051811897f2315414e714ac86211546a935660c4be6e85f1b
ToppCell10x5'v1-week_12-13-Myeloid_neutrophil-granulo-neutrophil-myelocyte|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TRPM6 CRYBG2 SLC5A10 PGLYRP1 ITGAM HPR CD101

1.30e-05182189752eac2f892ea7f26731e0b21c578fd2665a1657a
ToppCell5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

WNT2 CNTNAP3 HIF3A PKHD1L1 TLL1 DYNC1I1 HYAL2

1.35e-0518318972d0d3b486498a7903fa9a1f48b189291da49c430
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

HDAC9 RAPGEF4 DGKE PTPRB TLL1 ENTPD1 HYAL2

1.35e-051831897c1297d8eddfc7132e84ceef14f01b6281f9d0f6a
ToppCellPCW_10-12-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CHL1 CNTNAP3B CNTNAP3 SLC45A4 KL PTPRB ENTPD1

1.39e-051841897a809b0fa52df8a159f60f87eefcef61220af5e34
ToppCellCOPD-Epithelial-Mesothelial|World / Disease state, Lineage and Cell class

RERG PKHD1L1 HPR DIP2C C4A C4B PCK1

1.44e-05185189723579988036fc1925992c31919750f9b3fe9f790
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RERG OBSL1 CD163L1 ENTPD3 PLD5 SLC5A8 TBL1X

1.44e-0518518970b5a0df58ae2ad8261f40f152775747af4f3937a
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHANK1 GRM8 RYR2 NWD2 TLL1 PLD5 DYNC1I1

1.55e-0518718977b2cd0c618ed081223343f3bec2244c8723c9a31
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D175|Adult / Lineage, Cell type, age group and donor

CNTNAP3B RAPGEF4 CNTNAP3 HIF3A PKHD1L1 PTPRB TLL1

1.55e-0518718971e52d3d9d664c813d859b5b75e4c07b218818f95
ToppCellCOVID-19-lung-Artery_EC|lung / Disease (COVID-19 only), tissue and cell type

CHL1 CNTNAP3B RAPGEF4 HIF3A SLC45A4 PTPRB TLL1

1.60e-051881897eecd7482b3c97d7f49993cb17edfab30c61232fc
ToppCellEndothelial-endothelial_cell_of_lymph_vessel|World / Lineage, Cell type, age group and donor

CNTNAP3B RAPGEF4 CNTNAP3 PKHD1L1 PTPRB TLL1 HYAL2

1.60e-05188189780910dcbb51990f2baed240f319456c0d3fa2065
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CNTNAP3B HIF3A PKHD1L1 PTPRB TLL1 DYNC1I1 HYAL2

1.60e-051881897aeecbc057dc823f8fcea8a98f18d213bacc7f4db
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CNTNAP3B RAPGEF4 CNTNAP3 PKHD1L1 PTPRB SCAMP5 HYAL2

1.66e-0518918970d18ea72bd58d32a8ab9a61cf97f5786642f804b
ToppCellControl-Endothelial-VE_Venous|World / Disease state, Lineage and Cell class

CNTNAP3B RAPGEF4 HIF3A PKHD1L1 PTPRB TLL1 HYAL2

1.66e-051891897f83f7521e377ded1522639e9a35c98b3e2725bac
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CNTNAP3B RAPGEF4 CNTNAP3 PKHD1L1 PTPRB TLL1 HYAL2

1.66e-05189189755a1776a4ce049959b3f13a43744c7314bc1f00a
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CNTNAP3B RAPGEF4 PKHD1L1 PTPRB TLL1 ENTPD1 HYAL2

1.71e-051901897656483751e4bf137e4e4bfb2a03a478a8f7fcb63
ToppCellCOVID-19-lung-Artery_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

CHL1 RAPGEF4 HIF3A SLC45A4 PTPRB TLL1 ENTPD1

1.71e-05190189707b675befcd1d0a9c90cb17b5d22323468325d51
ToppCellIPF-Endothelial-Lymphatic|World / Disease state, Lineage and Cell class

CNTNAP3B RAPGEF4 HIF3A PKHD1L1 PTPRB TLL1 HYAL2

1.71e-051901897ac029e73da5995221c9b9af551d85e4b835e21d6
ToppCellControl-Endothelial-VE_Venous|Control / Disease state, Lineage and Cell class

CNTNAP3B RAPGEF4 HIF3A PKHD1L1 PTPRB TLL1 HYAL2

1.77e-051911897617546cf4883dedf3323e03a53ba5adec334cf8e
ToppCellCOVID-19-Heart-EC_(POSTN)|Heart / Disease (COVID-19 only), tissue and cell type

CNTNAP3B RAPGEF4 CNTNAP3 PKHD1L1 PTPRB TLL1 ENTPD1

1.83e-051921897c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCellLPS_only-Endothelial-Endothelial-Vein|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HDAC9 RAPGEF4 SFMBT2 PTPRB TLL1 ENTPD1 HYAL2

1.83e-05192189752acaecd3703166f5ce3b328aff7c82bd142fee4
ToppCellLPS-antiTNF-Endothelial-Endothelial-Vein|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HDAC9 RAPGEF4 SFMBT2 PTPRB TLL1 ENTPD1 HYAL2

1.83e-05192189781baf1c4063469bb0c03a8602b40e387ba7b0dfb
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CNTNAP3B RAPGEF4 DGKE PTPRB HMCN2 ENTPD1 HYAL2

1.83e-0519218973259cb89d6bcf0a3c6ff1f64d85e8a1f54124e91
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CNTNAP3B RAPGEF4 HIF3A PTPRB TLL1 ENTPD1 HYAL2

1.83e-05192189728eb3a5728e8901bcb5ba12f6b009f41b065fa37
ToppCellIPF-Endothelial-Lymphatic|IPF / Disease state, Lineage and Cell class

CNTNAP3B RAPGEF4 HIF3A PKHD1L1 PTPRB TLL1 HYAL2

1.83e-0519218972496edd8f3a41146d418879de9ee2ccc7857431f
ToppCellControl-Endothelial-Lymphatic|World / Disease state, Lineage and Cell class

CNTNAP3B RAPGEF4 HIF3A PKHD1L1 PTPRB TLL1 HYAL2

1.83e-051921897f95fb188aa642f3d0618242a770e7c4b70544adb
ComputationalGlycolysis and TCA cycle.

GAPDH ACO2 PCK1 PCK2

1.55e-04261154MODULE_306
ComputationalNeighborhood of CALM1

RALGAPA1 KDM3B GBA2 ACSL3 SCAMP5 HERC2 GPRASP2

1.71e-041101157GCM_CALM1
Drugdoxorubicinol

WNT2 ACO2 SOCS3 RYR2 TFRC

1.03e-06231865CID000083970
Drugcathenamine

GBA2 GBA3 C4A

2.13e-0641863CID000443361
DrugNSC-7616

WNT2 ACO2 ITIH4 TFRC SLC35G3 PCK2

3.23e-06501866CID000000309
Drugp-nitrophenyl-alpha-D-glucopyranoside

GALC MANBA DSPP LCT GBA2 GBA3 KL PCK2

5.11e-061161868CID000065115
Drugfagomine

MANBA LCT GBA2 GBA3

9.44e-06171864CID000072259
Drug5-amino-5-deoxy-D-mannopyranose

MANBA GBA2 GBA3

1.05e-0561863CID000124624
DrugAC1NSXES

GBA2 GBA3 SLC5A8

1.05e-0561863CID005318890
Drugriboxin

ENTPD1 ENTPD3 PCK1 PCK2 ENTPD8

1.06e-05361865CID000006831
Drugglucose-6-P

MANBA GAPDH ACO2 GBA2 PGD PLBD2 TFRC TG PIK3R4 GBA3 KL AP1G1 PCK2

1.06e-0536618613CID000000208
Drug4-methylumbelliferyl-beta-D-glucopyranoside

GALC MANBA LCT GBA2 GBA3

1.22e-05371865CID000087330
DrugLaevuflex

GAPDH ACR ITGA2B LCT GBA2 PGD GBA3 HPR HERC1 PCK1 PCK2

1.56e-0527218611CID000003426
DrugPlantagoside

MANBA GBA2 GBA3

1.83e-0571863CID000174157
Drugconvicine

GAPDH GBA2 GBA3

1.83e-0571863CID000088000
DrugDN-9693

ENTPD1 ENTPD3 ALDH7A1

1.83e-0571863CID000121868
Drugginsenoside Rb1

SLC5A7 GBA2 GBA3 PIK3R1 C4A

2.04e-05411865CID000073148
Drug1-deoxynojirimycin hydrochloride

GALC MANBA ADGRL1 LCT GBA2 ITIH4 GBA3

2.08e-051021867CID000001374
DrugAC1L3M3Y

GALC MANBA GAPDH GBA2 GBA3

2.30e-05421865CID000091455
DrugNSC624987

MANBA LCT GBA2 GBA3

2.81e-05221864CID000001472
DrugAC1LCZV5

GBA2 GBA3 C4A

2.92e-0581863CID000640056
Drugpyridoxine-5'-beta-D-glucoside

LCT GBA2 GBA3

2.92e-0581863CID000440188
Drugenantio-PAF-C16

PLB1 ITGAM PIK3R4 SLC6A13 KL ENTPD1 ENTPD3 C4A ART5 ALDH7A1

3.42e-0524418610CID000002499
Drugacetate

MANBA GAPDH ACR ACO2 GBA2 PGD PLBD2 DNAH1 GBA3 PTPRB PIK3R1 HPR SLC5A8 PCK1 PCK2 ALDH7A1

3.52e-0559918616CID000000175
DrugAC1L9HP3

DSPP ARF4 TG PIK3R4 ALG6 SEC13

3.73e-05761866CID000445265
DrugTetracaone hydrochloride [136-47-0]; Up 200; 13.2uM; MCF7; HT_HG-U133A

TRPM4 ICOSLG CRYBG2 NPTX1 DSPP GIPR SLC6A13 FGF6 MAGEC1

3.81e-0519818697473_UP
DrugAGEPC

GABRB1 GABRD PLB1 ITGA2B ITGAM GBA3 KL ENTPD1 ENTPD3 C4A ART5 ALDH7A1

3.88e-0535618612CID000461545
Drugrhamnose

GALC ACR BCAN LCT ITGAM GBA2 PGD ITIH4 TG GBA3 TSR1 HPR

3.88e-0535618612CID000000840
Drugpoly I

ACO2 POLR2B ITGAM DUOX1 HPR ASL ENTPD1 ENTPD3 SPPL2C ENTPD8

4.20e-0525018610CID000000797
DrugN-bromosuccinamide

MANBA GBA2 GBA3

4.35e-0591863CID009834204
Drugcppc

GAPDH PCK1 PCK2

4.35e-0591863CID000016521
Drugconduritol B

LCT GBA2 GBA3

4.35e-0591863CID000065317
DrugAC1L1IFV

TRPM6 P4HA2 GAPDH LCT KL ENTPD1

4.65e-05791866CID000004561
Drug62 p

DSPP ITGA2B ITGAM PIK3R4 ALDH7A1

4.91e-05491865CID006420118
Drugtrigalacturonate

TRPM6 MANBA GBA2 GBA3 HYAL2

5.42e-05501865CID000439239
Drug(2s,5s)-5-Carboxymethylproline

UIMC1 ITGA11 CENPB ITGA2B ITGAE ITGAM GRM8 TG PIK3R4 KL MAGEC1

5.80e-0531418611CID000447989
DrugAC1LCY75

LCT GBA3 C4A

6.17e-05101863CID000639298
DrugAC1MRQ63

GBA2 GBA3 ALDH7A1

6.17e-05101863CID003496897
DrugNSC106556

GBA2 GBA3

6.64e-0521862CID000267363
Drugallylacetylene

GBA2 GBA3

6.64e-0521862CID000522708
DrugR-G-P-G

ITIH4 C4A

6.64e-0521862CID000485269
Drugoxarbazole

DSPP C4A

6.64e-0521862CID000037184
DrugAC1L3ZSY

GBA2 GBA3

6.64e-0521862CID000098102
Drug1-hydroxy-3,7-dimethoxyxanthone

GBA2 GBA3

6.64e-0521862CID005488808
Drugbenzene-butanol

GBA2 GBA3

6.64e-0521862CID000076889
Drugtorvanol A

GBA2 GBA3

6.64e-0521862CID000639650
Drug8-Hydroxyquinoline-beta-D-glucoside

GBA2 GBA3

6.64e-0521862CID000152983
DrugCcris 6118

GBA2 GBA3

6.64e-0521862CID003085143
Drug3alpha-dihydrocadambine

GBA2 GBA3

6.64e-0521862CID000162138
Drugavenacoside B

GBA2 GBA3

6.64e-0521862CID000441878
Drugglucocheirolin

GBA2 GBA3

6.64e-0521862CID000656530
DrugAC1NSZ0V

GBA2 GBA3

6.64e-0521862CID005320067
Drugbalanitoside

GBA2 GBA3

6.64e-0521862CID000150711
Drug3-mat

GBA2 GBA3

6.64e-0521862CID006453430
DrugAC1LDLNP

GBA2 GBA3

6.64e-0521862CID000620782
DrugPurin-6-yl 6-deoxy-1-thio-beta-D-glucopyranoside

GBA2 GBA3

6.64e-0521862CID000130740
Drug3beta-isodihydrocadambine

GBA2 GBA3

6.64e-0521862CID000188431
Drugphenthoate oxon

GBA2 GBA3

6.64e-0521862CID000019398
DrugAmbap529-66-8

GBA2 GBA3

6.64e-0521862CID003083619
DrugDIMBOA-glucoside

GBA2 GBA3

6.64e-0521862CID000441563
Drugglucoside 1

GBA2 GBA3

6.64e-0521862CID006325268
Drugtheaspirane

GBA2 GBA3

6.64e-0521862CID000061953
Drugdimethylbellidifolin

GBA2 GBA3

6.64e-0521862CID005487856
Drug3,4,6-tri-O-methyl-D-glucose

GBA2 GBA3

6.64e-0521862CID000193713
Drugluteone

GBA2 GBA3

6.64e-0521862CID005281797
DrugGH 9

GBA2 GBA3 HYAL2

8.44e-05111863CID005488162
DrugCPPP

HPR ENTPD1 ENTPD3

8.44e-05111863CID000195490
Druglinalool

SOCS3 GBA2 GBA3 SLC5A8

8.73e-05291864CID000006549
DrugAMP group

RAPGEF6 GAPDH RAPGEF4 ADGRL1 DGKE TG ACSL3 ASL ENTPD1 ENTPD3 ART5 PCK2 DYNC1I1 ENTPD8 ALDH7A1

8.74e-0557918615CID000000224
Drugquercetin-4'-glucoside

LCT GBA2 GBA3

1.12e-04121863CID005320844
Drug8a beta-indolizidine-1 alpha, 2 alpha, 8 beta-triol

MANBA ADGRL1 LCT GBA2 ITIH4 GBA3

1.23e-04941866CID000005363
DrugNSC-614841

ITIH4 CD163 C4A

1.44e-04131863CID000357070
DrugMDL 25,637

LCT GBA2 GBA3

1.44e-04131863CID000128548
Drugcast 3

MANBA GBA2 GBA3

1.44e-04131863CID000072360
Drugmiglustat

LCT GBA2 ITIH4 TG GBA3 CD1D

1.46e-04971866CID000051634
Drugdaidzin

LCT GBA2 GBA3 ALDH7A1

1.47e-04331864CID000107971
DrugAC1OAGFB

TRPM4 COL20A1 RAPGEF4 CBLC DGKE CBL ARF4 ARF5 TFRC TG PIK3R1 HERC1 ART5 TBL1X

1.47e-0453918614CID006857345
DrugH S Q

GALC MANBA PGLYRP1 BCAN GBA2 ITIH4 TG GBA3 KL ALG6 HYAL2

1.55e-0435118611CID000000897
DrugRgd Peptide

CHL1 ITGA11 DSPP ITGA2B ITGAE ITGAM PIK3R4 ENTPD1 ENTPD3

1.61e-042391869CID000104802
Druglongum

MANBA LCT ITGAE GBA2 GBA3

1.65e-04631865CID000009047
Drugbaclofen

GABRB1 GABRD DSPP GRM8 RYR2 SLC6A13 PKD1 ART5

1.81e-041911868CID000002284
Drug2-chloro-4-nitrophenol

GAPDH GBA2 GBA3

1.83e-04141863CID000012074
DrugAC1NSXE4

GBA2 GBA3 SLC5A8

1.83e-04141863CID005318881
Drugindole-3-acetyl-l-valine

ITGA11 ITGA2B ITGAE ITGAM PIK3R4

1.91e-04651865CID000446641
DrugAC1L3VFE

LCT GBA2 GBA3 C4A ALDH7A1

1.91e-04651865CID000122880
DrugNSC103055

GBA2 GBA3

1.98e-0431862CID000266052
Drugthiophosphoenolpyruvate

PCK1 PCK2

1.98e-0431862CID000146003
DrugNSC-167733

SOCS3 TG

1.98e-0431862CID000062281
Drugtorvoside H

GBA2 GBA3

1.98e-0431862CID000639649
DrugNSC721382

GBA2 GBA3

1.98e-0431862CID000404838
Drug2',4'-dinitrophenyl beta-D-galactopyranoside

GBA2 GBA3

1.98e-0431862CID000152809
DrugAC1Q5X08

GBA2 GBA3

1.98e-0431862CID000125153
DrugFU-O-G

GBA2 GBA3

1.98e-0431862CID000125172
Drugprotogracillin

GBA2 GBA3

1.98e-0431862CID000441892
Drug2-aminothiophenol

C4A C4B

1.98e-0431862ctd:C005464
Drugbioside

GBA2 GBA3

1.98e-0431862CID003084119
DrugAC1L2O6A

GBA2 GBA3

1.98e-0431862CID000100152
Drug(5S,6R,7S,8R)-5-methylol-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-6,7,8-triol

MANBA GBA3

1.98e-0431862CID009990375
DrugCellobiose octaacetate

GBA2 GBA3

1.98e-0431862CID000104455
Drugphloroglucinaldehyde

GBA2 GBA3

1.98e-0431862CID000068099
Drug6-bromo-2-naphthyl-beta-d-glucoside

GBA2 GBA3

1.98e-0431862CID000084983
Drug3'-galactosyllactose

GBA2 GBA3

1.98e-0431862CID000189088
DiseaseSchizophrenia

GABRB1 CHL1 SHANK1 GABRD HDAC9 RAPGEF6 SRD5A2 BACE1 CMYA5 ITGAM GRM8 CD163 SLC6A9 EDEM2 MAGEC1 C9orf72 PCK1 KPNA3

9.17e-0688318118C0036341
DiseasePhosphoenolpyruvate carboxykinase deficiency

PCK1 PCK2

3.74e-0521812C0268194
Diseaseaspartate aminotransferase measurement

P4HA2 PLB1 RAPGEF6 SRD5A2 IPP LCT CD163 SLC45A4 GBA3 DGLUCY NPHP3 HMCN2 ERAP2 PIK3R1 HPR EDEM2 IFT80

4.52e-0590418117EFO_0004736
Diseaseautistic disorder (is_implicated_in)

GABRB1 RAPGEF4 GRM8 C4B

1.28e-04421814DOID:12849 (is_implicated_in)
DiseaseAutistic Disorder

GABRB1 SHANK1 WNT2 COP1 GRM8 SCAMP5 C4B PLD5

2.21e-042611818C0004352
Diseasekallikrein-7 measurement

CD163 CD163L1

3.70e-0451812EFO_0008195
DiseaseShort rib-polydactyly syndrome, Verma-Naumoff type

DYNC2I2 IFT80

3.70e-0451812C0432197
Diseaseeye colour measurement

HDAC9 RERG CNTNAP3 PLBD2 NWD2 CRYBG1 HERC2

4.14e-042181817EFO_0009764
Diseasecomplement factor H-related protein 2 measurement

CHL1 CFHR4 DYNC1I1

7.38e-04291813EFO_0600055
Diseaseautosomal recessive intellectual developmental disorder (implicated_via_orthology)

CNTNAP3B CNTNAP3

1.02e-0381812DOID:0060308 (implicated_via_orthology)
Diseasebody shape measurement

GRM8 TRAP1

1.02e-0381812EFO_0801227
DiseaseComplement deficiency disease

CFHR4 C4A C4B

1.08e-03331813C0272242
DiseaseLiver carcinoma

GABRD GAPDH ACO2 SOCS3 PGD CD163 GBA3 BUB1B PCK1 HERC5

1.22e-0350718110C2239176
Diseasealkaline phosphatase measurement

RALGAPA1 MANBA SRD5A2 ERMP1 ITIH4 CFHR4 NWD2 NPHP3 ASL EDEM2 PKD1 FGF6 PCK1 RIC1 KLHL17

1.55e-03101518115EFO_0004533
DiseaseCongenital myasthenic syndrome

MYO9A SLC5A7

1.63e-03101812cv:C0751882
Diseaseabdominal aortic calcification measurement

HDAC9 PIK3R4

1.63e-03101812EFO_0010272
DiseaseGraves' disease (is_implicated_in)

TG C4A C4B

1.76e-03391813DOID:12361 (is_implicated_in)
Diseaseplatelet-to-lymphocyte ratio

HDAC9 MANBA ACO2 PSMB9 ITGA2B CBL PGD TNKS1BP1

1.88e-033631818EFO_0008446
DiseaseJeune thoracic dystrophy

DYNC2I2 IFT80

1.98e-03111812C0265275
Diseaseosteosarcoma (is_marker_for)

CBL PTPRB

1.98e-03111812DOID:3347 (is_marker_for)
Diseasekidney disease (implicated_via_orthology)

LCT GBA3 KL

2.04e-03411813DOID:557 (implicated_via_orthology)
Diseaserespiratory system disease

ACO2 SOCS3 ERMP1 TFRC RIC1

2.05e-031451815EFO_0000684
DiseaseS-6-hydroxywarfarin to S-warfarin ratio measurement

SRD5A2 TFRC HERC4 PCK1

2.14e-03881814EFO_0803332
Diseaseserum metabolite measurement

GABRB1 RALGAPA1 PKD1L1 IPP ERMP1 PKD1L2 ITGAM SLC45A4 GBA3 SLC6A13 NWD2 ERAP2 DIP2C RIC1

2.16e-0394518114EFO_0005653
Diseasetype 2 diabetes mellitus (biomarker_via_orthology)

SOCS3 ITGAM KL PIK3R1 HPR

2.18e-031471815DOID:9352 (biomarker_via_orthology)
Diseaseobesity (biomarker_via_orthology)

GAPDH SOCS3 ITIH4 PIK3R1 HPR

2.18e-031471815DOID:9970 (biomarker_via_orthology)
Diseaseautoimmune thyroiditis (is_implicated_in)

PSMB9 TG

2.37e-03121812DOID:7188 (is_implicated_in)
DiseaseAnxiety States, Neurotic

SHANK1 GRM8 TG

2.50e-03441813C0376280
DiseaseAnxiety neurosis (finding)

SHANK1 GRM8 TG

2.50e-03441813C1279420
DiseaseAnxiety Disorders

SHANK1 GRM8 TG

2.50e-03441813C0003469
Diseaseautism spectrum disorder (implicated_via_orthology)

SHANK1 CNTNAP3B CNTNAP3 SCAMP5 GPRASP2

2.52e-031521815DOID:0060041 (implicated_via_orthology)
Diseasehypothyroidism (implicated_via_orthology)

TG DUOX1

2.79e-03131812DOID:1459 (implicated_via_orthology)
Diseaseprostate cancer (is_marker_for)

WNT2 SRD5A2 TFRC ACSL3 PIK3R1

2.81e-031561815DOID:10283 (is_marker_for)
Diseaseautosomal dominant polycystic kidney disease (implicated_via_orthology)

NPHP3 PKD1

3.24e-03141812DOID:898 (implicated_via_orthology)
Diseasetriacylglycerol 48:4 measurement

SFMBT2 PLD5

3.24e-03141812EFO_0010407
Diseasecongenital hypothyroidism (implicated_via_orthology)

TG DUOX1

3.24e-03141812DOID:0050328 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

CHL1 GRM8 SCAMP5 KCNK17 ALDH7A1

3.40e-031631815DOID:1826 (implicated_via_orthology)
Diseasecreatinine measurement

RERG P4HA2 MANBA GIPR SLC6A13 DUOX1 SPPL2A PIK3R1 EDEM2 DIP2C FGF6 CFAP57 PCK1 KPNA3

3.44e-0399518114EFO_0004518
Disease2-hydroxyglutarate measurement

DGLUCY PLD5

4.24e-03161812EFO_0021506
Diseasemyopia (is_implicated_in)

P4HA2 LOXL3

4.24e-03161812DOID:11830 (is_implicated_in)
Diseaseamygdala volume change measurement

GABRB1 PKD1L1

4.24e-03161812EFO_0021490
DiseaseAbnormal behavior

KDM3B SCAMP5

4.24e-03161812C0233514
Diseaseresponse to reverse transcriptase inhibitor, HIV-1 infection, peripheral neuropathy

HDAC9 HIF3A PTPRB

4.48e-03541813EFO_0000180, EFO_0003100, GO_0061479
DiseaseIschemic stroke, fibrinogen measurement

HDAC9 RAPGEF6 SPPL2A

4.71e-03551813EFO_0004623, HP_0002140
DiseaseRespiratory Distress Syndrome, Adult

GABRB1 ACO2 LCT

4.71e-03551813C0035222
DiseaseS-7-hydroxywarfarin measurement

TGM5 PIK3R1 FGF6 HERC4

4.77e-031101814EFO_0803329
DiseaseUnipolar Depression

HDAC9 SLC5A7 CMYA5 TG SLC6A13 KPNA3

5.41e-032591816C0041696
Diseasecreatine kinase measurement

SOCS3 CD163 CD163L1

5.74e-03591813EFO_0004534
Diseasebreast cancer (is_marker_for)

RERG WNT2 KDM3B TFRC ACSL3

5.79e-031851815DOID:1612 (is_marker_for)
Diseasecreatinine measurement, glomerular filtration rate

RERG MANBA SLC6A13 PIK3R1

5.93e-031171814EFO_0004518, EFO_0005208
DiseaseCongenital Myasthenic Syndromes, Presynaptic

MYO9A SLC5A7

5.97e-03191812C0751884
Diseasetype 1 diabetes mellitus (biomarker_via_orthology)

CBL HPR

5.97e-03191812DOID:9744 (biomarker_via_orthology)
DiseaseInsulin Resistance

ITGAM CD163 PIK3R1

6.01e-03601813C0021655
DiseaseInsulin Sensitivity

ITGAM CD163 PIK3R1

6.01e-03601813C0920563

Protein segments in the cluster

PeptideGeneStartEntry
GIGVSLAQFYISWAE

BUB1B

146

O60566
RWVVIGDENYGEGSS

ACO2

656

Q99798
YEGTVILWDGFTGQR

COP1

491

Q8NHY2
INGSNWEGILGLAYA

BACE1

171

P56817
VTAVATQGGYGSSDW

CNTNAP3

91

Q9BZ76
GQWAIGYVSSDGSIL

CBLC

271

Q9ULV8
AQETGDNLYWGSVTG

C4B

1221

P0C0L5
GLREENEGVYNGSWG

ALDH7A1

46

P49419
YNSVSLGFALWGVLG

ALG6

166

Q9Y672
ESAYVVVGITSWGVG

ACR

251

P10323
AVDENGLWVIYATEG

ADGRL1

271

O94910
TQGTGLYDGLDWLSH

ARF5

161

P84085
QWAGGGDSDKLSYSL

FAM220BP

16

B1ANY3
AGEIAGVNWESGYLV

FGF6

66

P10767
ATEFGWTLNYGGIAL

PGD

346

P52209
IEGWNGDTGKAETYG

DSPP

106

Q9NZW4
GSKGQTAGELYQRWE

GIPR

26

P48546
GFGNIDGEYWLGLEN

ANGPTL1

341

O95841
GNASTGYGKIWLDDV

CD163L1

636

Q9NR16
DSGIWINGFDYTGIS

ERMP1

706

Q7Z2K6
IISGQEEGVYGWITA

ENTPD3

176

O75355
VGGTLGQFYQEVLWG

ITIH4

871

Q14624
HTILADYFLGVWSGG

NWD2

756

Q9ULI1
AETSDGGVYWEGIDE

PCK1

361

P35558
YIELWDVGGSVGSAS

RABL3

61

Q5HYI8
EYGGLSLWSVFGAQL

RIC1

326

Q4ADV7
AIYALGGWVGAEIGN

IPP

391

Q9Y573
TRDGVWEAYQDGTQG

NPTX1

321

Q15818
AAWCIGEYGDLLVSG

AP1G1

476

O43747
ANQVTGWLDGSAIYG

DUOX1

166

Q9NRD9
EGVTGEWARGGVQLY

OBSL1

1566

O75147
GAEIATTGQLYAAWD

BCAN

281

Q96GW7
ADLTKGYLQWVSEGG

LPIN3

696

Q9BQK8
VNWTPGGGDVDSYTV

PTPRB

926

P23467
GAAGVILWGDAGYTT

HYAL2

321

Q12891
DTVWALSYLTDGGNE

KPNA3

261

O00505
NFGEQGITVGCWDLY

LOXL3

656

P58215
GTYASEEVIWDVLSG

MAGEC1

1011

O60732
AGLYDDISTQGWFIG

CHL1

1071

O00533
WQEGLLVTFDGGYLS

LRRK1

1086

Q38SD2
YTWGDNDEGQLGDGT

HERC2

4271

O95714
QAEGAFGWITVNYGL

ENTPD8

166

Q5MY95
SLWLENVETGDAGTY

HMCN2

4356

Q8NDA2
EVGRVGYVSGWGQSD

HPR

216

P00739
QYGALGGTARSSVDW

ASL

436

P04424
KLISGGTDGAVYEWN

CFAP57

526

Q96MR6
GTDGAVYEWNLSTGK

CFAP57

531

Q96MR6
VTEDGELYTWGEGDF

HERC1

526

Q15751
DVYAWGSNSEGQLGL

HERC1

4311

Q15751
YEVEIWTGDVGGAGT

LOXHD1

816

Q8IVV2
VVGGTYSGQIVLWDN

DYNC1I1

356

O14576
SHVAGGLYSGEVLVW

DYNC2I2

231

Q96EX3
VASGITVDWAYDSGI

CPA5

376

Q8WXQ8
WVAQDAGIGAGVDSY

EDEM2

246

Q9BV94
VGAFDWSGGALLYDT

ITGAE

421

P38570
EGSILATKQEYWGNG

CD200R1L

176

Q6Q8B3
GVVIAGYTSGDVRVW

FBXW8

221

Q8N3Y1
TNVAETSDGGVYWEG

PCK2

376

Q16822
AYLALGTGVFWTLEG

KCNK17

31

Q96T54
EDGLVYEGRGWNFTG

PGLYRP1

101

O75594
FLVGQDGAIYEGVGW

PGLYRP4

276

Q96LB8
DGAIYEGVGWNVQGS

PGLYRP4

281

Q96LB8
YAWGLDSDGQLGLVG

HERC4

106

Q5GLZ8
VGDSLEVAYTGWLFQ

FKBP15

196

Q5T1M5
YGVQGWAIVQFLGDA

KDM3B

1666

Q7LBC6
DFLWGVSSSAYQIEG

LCT

906

P09848
TDDIEFYWNGGEGAV

GABRB1

186

P18505
NDIGDYVGSNLEISW

GABRD

26

O14764
SGFWYILATATDAQG

LCN10

41

Q6JVE6
VEDGVLLGAVGAYDW

ITGA11

376

Q9UKX5
LLGAVGAYDWNGAVL

ITGA11

381

Q9UKX5
SEVVGYLGGRWDVNS

MPND

291

Q8N594
AGWDQREGGQVYGTL

PSMB9

121

P28065
EEIGWLNGYNETTGE

PIK3R1

51

P27986
ARIITGQEEGAYGWI

ENTPD1

166

P49961
TALGWNYVSTLASEG

GRM8

211

O00222
GLWSAYQDGELQGSG

NPTXR

391

O95502
LWIQVELDGGTGVTY

PKD1L2

371

Q7Z442
GTAVFWYNLLRSGEG

P4HA2

481

O15460
YAGAWAVSPETELTG

ICOSLG

286

O75144
WVSFSGEIGYDLGGV

HERC5

711

Q9UII4
GSGKSNVGTWGDYDD

POTEB3

111

A0JP26
SVGNILGSLIAGYWV

SLC37A1

201

P57057
AGEINYGGRVTDDWD

DNAH1

3876

Q9P2D7
WAQGVVEAGGSFGAY

CENPB

476

P07199
SVTWYLTQDGGGSQA

CD101

181

Q93033
AGRWNYEGTALVTVG

IFT80

111

Q9P2H3
SEGTIWGQLGEDSDY

GRID2IP

841

A4D2P6
DGWLYAVGGNDGSSS

KLHL17

576

Q6TDP4
QSDEVWVGVVYGLAA

GBA2

816

Q9HCG7
GFGWAAATAAYQVEG

GBA3

6

Q9H227
LEGQDIVLYWGGSYT

CD1D

286

P15813
WRESEGSGLGYLVQV

COL20A1

46

Q9P218
AVQAGALGQGETSWY

CMYA5

3966

Q8N3K9
LSGVWVAYQEVGFSG

CRYBG2

1301

Q8N1P7
GDTQTIWARTGYLGF

DIP2C

1406

Q9Y2E4
YGNTTGSIVCGEDGW

CFHR4

431

Q92496
TLRVWGGGIYEQDEF

MANBA

386

O00462
AGNGSWTDSVAFYIL

INSRR

896

P14616
SVGAQTTAGWNYLLE

ERAP2

796

Q6P179
LWAVGSAAYQTEGGW

KL

66

Q9UEF7
AAFEYVGENIWLGGI

GLIPR1L1

91

Q6UWM5
GQWAIGYVTADGNIL

CBL

301

P22681
SGGSWVVYDGENFTG

CRYBG1

1451

Q9Y4K1
LSNTLGWGTGYAGEI

DGKE

316

P52429
GDTQTIWARTGYLGF

DIP2A

1421

Q14689
GTGLGEGYNINIAWT

HDAC9

861

Q9UKV0
DFAVIAGVSNWGGYA

DGLUCY

511

Q7Z3D6
AGRLEVFYNGAWGTV

CD163

836

Q86VB7
ANGSYRVTGDLAGWI

GALC

601

P54803
YRGSGGSFSKAQEEW

SCAMP5

176

Q8TAC9
EEWGGNGVGDDLFSY

RYR2

711

Q92736
VSGNWIEIAYGTSSG

KCTD3

381

Q9Y597
AYLWDFGDGTVSLGS

PKD1L1

621

Q8TDX9
GNWNGDRSTYGLSII

C9orf72

101

Q96LT7
AQETGDNLYWGSVTG

C4A

1221

P0C0L4
VTAVATQGGYGSSDW

CNTNAP3B

91

Q96NU0
AEGWAGNQSVVGVIY

LRRN4

616

Q8WUT4
AGEIWNGGIDECTLY

OTOGL

1876

Q3ZCN5
ELAGGSGVVYTWSLE

PKD1

1741

P98161
FLGANAVWYGAVGDS

PKD1

3291

P98161
LLASWGAGATTFQEY

MUCL3

21

Q3MIW9
NGVAGQDYWAVLSGK

MS4A12

186

Q9NXJ0
YSVATQLFIGGVTGW

FUNDC2

81

Q9BWH2
TWVGGGYINGTAEAV

SLC5A7

61

Q9GZV3
DGAISLLTYTGEGQW

SEC13

126

P55735
GTVLFNQGEEGTSWY

RAPGEF4

381

Q8WZA2
GLWTLQEGTTGVYTA

SLC35G3

176

Q8N808
GDYAWGQTGLDAIVT

RNF115

176

Q9Y4L5
DGQELDSWYVILNGT

RAPGEF6

311

Q8TEU7
VYIGSAGLDWQSLGQ

PLD5

231

Q8N7P1
ASGIVFYGELWVCAG

TLL1

16

O43897
GGLVNSLGWVLSAYA

SLC16A14

106

Q7RTX9
GTQCEYWTGGALGSE

NPHP3

226

Q7Z494
GAIGGSAYWAEEKSS

GPRASP2

416

Q96D09
KWGDAGAEYVVESTG

GAPDH

86

P04406
GGYLWTQTQATVVSG

HIF3A

311

Q9Y2N7
SYVISGDGNGKLNIW

CDC40

521

O60508
FILAVGTVAAGGYWA

SPPL2C

191

Q8IUH8
SDGLKYSLATGNWGD

POLR2B

441

P30876
IIGGTFTWTSIYGVN

SLC5A8

246

Q8N695
GGTWYGVDINNEDIA

CCT7

471

Q99832
AETGSKYVGTWVNGQ

RSPH1

131

Q8WYR4
WGYSVAVGEFDGDLN

ITGA2B

266

P08514
LSTVGSYDWAGGVFL

ITGAM

366

P11215
DVLTQYRGLSWSVGG

PLB1

416

Q6P1J6
YRGLSWSVGGDENIG

PLB1

421

Q6P1J6
SEGAAEIAGYQTLWE

SERTAD4

16

Q9NUC0
GDFGSVGATEWLEGY

TFRC

456

P02786
GWIYLGLNSSGEELN

SYT14P1

151

Q58G82
WGEGFVLVYDITDRG

RERG

76

Q96A58
YLESVDEGGVAWRAG

SHANK1

701

Q9Y566
AGAGTISEVWDYNTG

ACSL3

481

O95573
TQGTGLYEGLDWLSN

ARF4

161

P18085
LEENGKVYGNWTFGT

ATP11C

986

Q8NB49
GEYTDIQGLEWSGNF

MORN2

51

Q502X0
VLAYATVNGSLVGWD

PIK3R4

1111

Q99570
YVLGGLDWTQTFLGS

SLC45A4

211

Q5BKX6
WNTNGTLLATGSYDG

TBL1X

296

O60907
GSYDGFARIWTEDGN

TBL1X

306

O60907
YEEGWLATGNGRGVV

TULP4

41

Q9NRJ4
SYGEFGNVTRWSLGI

RNFT1

311

Q5M7Z0
IFDWGGCSDNIDYGI

WNT2

151

P09544
GGKWIVSGSEDNLVY

WDR5B

266

Q86VZ2
GTSSYQAEWILDGGS

TSR1

396

Q2NL82
GYVNWAFSEGDETGV

TRPM6

1451

Q9BX84
GSQAYEDFVAGLGWE

RALGAPA1

1831

Q6GYQ0
LGIQLAWGFYGNTVT

TCTA

51

P57738
GGLAVAGFEWNATYV

SLC5A10

86

A0PJK1
SGNTIYFGEGSWLTV

TRBJ1-3

1

A0A0J9YWP8
ALGQYTSQGGVTAWR

SLC6A13

91

Q9NSD5
FTVALGGYWSGLVEL

SPPL2A

181

Q8TCT8
ERDWTSKYGQGAGEG

TNKS1BP1

771

Q9C0C2
GSSLEETGFNWGEYL

SFMBT2

36

Q5VUG0
ETGFNWGEYLEETGA

SFMBT2

41

Q5VUG0
YDSGDEWDIGVGNLI

ZNF609

21

O15014
VGYINGTFDLVWGNG

USP47

81

Q96K76
LTSVGYAVGLGNVWR

SLC6A9

111

P48067
GANFLGEIIEWIGYA

SRD5A2

191

P31213
LQESGFYWSAVTGGE

SOCS3

41

O14543
EWDGNSQVGIGDYRI

PKHD1L1

3706

Q86WI1
YTDGANPAEWTGSVA

TGM5

246

O43548
GLWTLQEGITGVYTA

SLC35G6

176

P0C7Q6
VWSDYVGGRNGDLEE

ZG16

71

O60844
SLGYQWLSDGSGVFE

TRAP1

226

Q12931
LDSYGWLVSGGQSGL

GTF3C2

846

Q8WUA4
TGWAFLELGTSGQYN

PLBD2

96

Q8NHP8
YVVNFGAGDGANWLT

TRAPPC10

256

P48553
TGEYARLQASGAGTW

TG

1111

P01266
GLQDTGGTVNYFWGI

UIMC1

266

Q96RL1
FLGVWLVAYGVATEG

TRPM4

936

Q8TD43
TGGYNLASVSVWDLA

TLE6

351

Q9H808
WGQYATDGIGNESVK

TMEM145

226

Q8NBT3
ATGAYNGTVRIWDFG

WDR64

516

B1ANS9
GLLWISGGVTNTAQY

KLHL32

446

Q96NJ5
LYWELNQAVRTGGGS

ART5

106

Q96L15
YGSLEIQGSDPSGWE

MYO9A

1181

B2RTY4