| Category | Name | IntersectionWithQuery | PValue | GenesInTerm | GenesInQuery | GenesInTermInQuery | ID |
|---|---|---|---|---|---|---|---|
| GeneOntologyMolecularFunction | DNA-binding transcription factor activity, RNA polymerase II-specific | HOXA11 HOXB1 MYPOP HOXC11 HOXC12 HOXD1 HOXD11 HOXD12 MNX1 DBX2 PDX1 EVX1 DLX2 IRX6 IRX2 EVX2 MEOX1 HOXA1 | 4.79e-10 | 1412 | 45 | 18 | GO:0000981 |
| GeneOntologyMolecularFunction | RNA polymerase II cis-regulatory region sequence-specific DNA binding | HOXA11 HOXB1 MYPOP HOXC11 HOXD1 HOXD11 PDX1 KDM2B EVX1 DLX2 IRX6 IRX2 TOP1 EVX2 MEOX1 HOXA1 | 5.41e-09 | 1244 | 45 | 16 | GO:0000978 |
| GeneOntologyMolecularFunction | cis-regulatory region sequence-specific DNA binding | HOXA11 HOXB1 MYPOP HOXC11 HOXD1 HOXD11 PDX1 KDM2B EVX1 DLX2 IRX6 IRX2 TOP1 EVX2 MEOX1 HOXA1 | 7.35e-09 | 1271 | 45 | 16 | GO:0000987 |
| GeneOntologyMolecularFunction | RNA polymerase II transcription regulatory region sequence-specific DNA binding | HOXA11 HOXB1 MYPOP HOXC11 HOXD1 HOXD11 PDX1 KDM2B EVX1 DLX2 IRX6 IRX2 TOP1 EVX2 MEOX1 HOXA1 | 5.15e-08 | 1459 | 45 | 16 | GO:0000977 |
| GeneOntologyMolecularFunction | DNA-binding transcription activator activity, RNA polymerase II-specific | 1.52e-03 | 560 | 45 | 6 | GO:0001228 | |
| GeneOntologyMolecularFunction | DNA-binding transcription activator activity | 1.61e-03 | 566 | 45 | 6 | GO:0001216 | |
| GeneOntologyBiologicalProcess | pattern specification process | HOXA11 HOXB1 HOXC11 HOXD11 HOXD12 MNX1 CFAP45 KDM2B DLX2 IRX2 MEOX1 HOXA1 | 8.93e-10 | 526 | 45 | 12 | GO:0007389 |
| GeneOntologyBiologicalProcess | embryo development | HOXA11 HOXB1 HOXC11 HOXD1 HOXD11 HOXD12 MNX1 PDX1 KDM2B CHD8 EVX1 DLX2 CPLANE1 IRX2 TOP1 MEOX1 HOXA1 | 3.31e-09 | 1437 | 45 | 17 | GO:0009790 |
| GeneOntologyBiologicalProcess | regionalization | HOXA11 HOXB1 HOXC11 HOXD11 MNX1 CFAP45 KDM2B DLX2 IRX2 MEOX1 HOXA1 | 4.60e-09 | 478 | 45 | 11 | GO:0003002 |
| GeneOntologyBiologicalProcess | proximal/distal pattern formation | 1.63e-08 | 37 | 45 | 5 | GO:0009954 | |
| GeneOntologyBiologicalProcess | embryonic skeletal system development | 3.07e-08 | 148 | 45 | 7 | GO:0048706 | |
| GeneOntologyBiologicalProcess | embryonic skeletal system morphogenesis | 1.31e-07 | 109 | 45 | 6 | GO:0048704 | |
| GeneOntologyBiologicalProcess | embryonic morphogenesis | HOXA11 HOXB1 HOXC11 HOXD11 HOXD12 PDX1 KDM2B DLX2 CPLANE1 IRX2 HOXA1 | 2.71e-07 | 713 | 45 | 11 | GO:0048598 |
| GeneOntologyBiologicalProcess | embryo development ending in birth or egg hatching | HOXA11 HOXB1 HOXC11 HOXD1 HOXD11 MNX1 KDM2B CHD8 EVX1 DLX2 MEOX1 HOXA1 | 4.72e-07 | 929 | 45 | 12 | GO:0009792 |
| GeneOntologyBiologicalProcess | embryonic digit morphogenesis | 5.66e-07 | 74 | 45 | 5 | GO:0042733 | |
| GeneOntologyBiologicalProcess | anterior/posterior pattern specification | 9.99e-07 | 247 | 45 | 7 | GO:0009952 | |
| GeneOntologyBiologicalProcess | embryonic skeletal joint morphogenesis | 2.73e-06 | 13 | 45 | 3 | GO:0060272 | |
| GeneOntologyBiologicalProcess | chordate embryonic development | HOXA11 HOXB1 HOXC11 HOXD1 HOXD11 MNX1 KDM2B CHD8 DLX2 MEOX1 HOXA1 | 2.84e-06 | 906 | 45 | 11 | GO:0043009 |
| GeneOntologyBiologicalProcess | appendage morphogenesis | 2.92e-06 | 185 | 45 | 6 | GO:0035107 | |
| GeneOntologyBiologicalProcess | limb morphogenesis | 2.92e-06 | 185 | 45 | 6 | GO:0035108 | |
| GeneOntologyBiologicalProcess | skeletal system development | 5.96e-06 | 615 | 45 | 9 | GO:0001501 | |
| GeneOntologyBiologicalProcess | embryonic skeletal joint development | 6.46e-06 | 17 | 45 | 3 | GO:0072498 | |
| GeneOntologyBiologicalProcess | limb development | 8.77e-06 | 224 | 45 | 6 | GO:0060173 | |
| GeneOntologyBiologicalProcess | appendage development | 8.77e-06 | 224 | 45 | 6 | GO:0048736 | |
| GeneOntologyBiologicalProcess | embryonic organ morphogenesis | 1.01e-05 | 351 | 45 | 7 | GO:0048562 | |
| GeneOntologyBiologicalProcess | positive regulation of chondrocyte development | 1.39e-05 | 3 | 45 | 2 | GO:1902761 | |
| GeneOntologyBiologicalProcess | rhombomere 4 development | 1.39e-05 | 3 | 45 | 2 | GO:0021570 | |
| GeneOntologyBiologicalProcess | facial nucleus development | 1.39e-05 | 3 | 45 | 2 | GO:0021754 | |
| GeneOntologyBiologicalProcess | embryonic limb morphogenesis | 1.72e-05 | 148 | 45 | 5 | GO:0030326 | |
| GeneOntologyBiologicalProcess | embryonic appendage morphogenesis | 1.72e-05 | 148 | 45 | 5 | GO:0035113 | |
| GeneOntologyBiologicalProcess | organ induction | 2.44e-05 | 26 | 45 | 3 | GO:0001759 | |
| GeneOntologyBiologicalProcess | rhombomere 5 development | 2.78e-05 | 4 | 45 | 2 | GO:0021571 | |
| GeneOntologyBiologicalProcess | skeletal system morphogenesis | 2.92e-05 | 277 | 45 | 6 | GO:0048705 | |
| GeneOntologyBiologicalProcess | regulation of animal organ formation | 4.60e-05 | 32 | 45 | 3 | GO:0003156 | |
| GeneOntologyBiologicalProcess | metanephros development | 5.44e-05 | 95 | 45 | 4 | GO:0001656 | |
| GeneOntologyBiologicalProcess | hindbrain development | 8.75e-05 | 208 | 45 | 5 | GO:0030902 | |
| GeneOntologyBiologicalProcess | specification of animal organ identity | 9.76e-05 | 41 | 45 | 3 | GO:0010092 | |
| GeneOntologyBiologicalProcess | positive regulation of animal organ morphogenesis | 9.76e-05 | 41 | 45 | 3 | GO:0110110 | |
| GeneOntologyBiologicalProcess | developmental induction | 9.76e-05 | 41 | 45 | 3 | GO:0031128 | |
| GeneOntologyBiologicalProcess | regulation of chondrocyte development | 1.29e-04 | 8 | 45 | 2 | GO:0061181 | |
| GeneOntologyBiologicalProcess | kidney development | 1.49e-04 | 372 | 45 | 6 | GO:0001822 | |
| GeneOntologyBiologicalProcess | rhombomere development | 1.66e-04 | 9 | 45 | 2 | GO:0021546 | |
| GeneOntologyBiologicalProcess | renal system development | 1.82e-04 | 386 | 45 | 6 | GO:0072001 | |
| GeneOntologyBiologicalProcess | embryonic organ development | 1.96e-04 | 561 | 45 | 7 | GO:0048568 | |
| GeneOntologyBiologicalProcess | facial nerve structural organization | 2.07e-04 | 10 | 45 | 2 | GO:0021612 | |
| GeneOntologyBiologicalProcess | anatomical structure formation involved in morphogenesis | HOXA11 HOXB1 HOXC11 HOXD11 KDM2B KLHL41 IRX6 CCDC38 IRX2 MEOX1 HOXA1 | 2.66e-04 | 1483 | 45 | 11 | GO:0048646 |
| GeneOntologyBiologicalProcess | facial nerve morphogenesis | 3.03e-04 | 12 | 45 | 2 | GO:0021610 | |
| GeneOntologyBiologicalProcess | facial nerve development | 3.03e-04 | 12 | 45 | 2 | GO:0021561 | |
| GeneOntologyBiologicalProcess | animal organ morphogenesis | 3.30e-04 | 1269 | 45 | 10 | GO:0009887 | |
| GeneOntologyBiologicalProcess | metencephalon development | 3.42e-04 | 153 | 45 | 4 | GO:0022037 | |
| GeneOntologyBiologicalProcess | cranial nerve structural organization | 3.58e-04 | 13 | 45 | 2 | GO:0021604 | |
| GeneOntologyBiologicalProcess | pons development | 4.80e-04 | 15 | 45 | 2 | GO:0021548 | |
| GeneOntologyBiologicalProcess | animal organ formation | 6.58e-04 | 78 | 45 | 3 | GO:0048645 | |
| GeneOntologyBiologicalProcess | positive regulation of transcription by RNA polymerase II | 6.79e-04 | 1390 | 45 | 10 | GO:0045944 | |
| GeneOntologyBiologicalProcess | negative regulation of DNA-templated transcription | 7.14e-04 | 1399 | 45 | 10 | GO:0045892 | |
| GeneOntologyBiologicalProcess | negative regulation of RNA biosynthetic process | 7.71e-04 | 1413 | 45 | 10 | GO:1902679 | |
| GeneOntologyBiologicalProcess | preganglionic parasympathetic fiber development | 7.77e-04 | 19 | 45 | 2 | GO:0021783 | |
| GeneOntologyBiologicalProcess | nephron tubule morphogenesis | 9.05e-04 | 87 | 45 | 3 | GO:0072078 | |
| GeneOntologyBiologicalProcess | anatomical structure arrangement | 9.52e-04 | 21 | 45 | 2 | GO:0048532 | |
| GeneOntologyBiologicalProcess | nephron epithelium morphogenesis | 9.67e-04 | 89 | 45 | 3 | GO:0072088 | |
| GeneOntologyBiologicalProcess | nephron morphogenesis | 1.03e-03 | 91 | 45 | 3 | GO:0072028 | |
| GeneOntologyBiologicalProcess | parasympathetic nervous system development | 1.05e-03 | 22 | 45 | 2 | GO:0048486 | |
| GeneOntologyBiologicalProcess | segment specification | 1.05e-03 | 22 | 45 | 2 | GO:0007379 | |
| GeneOntologyBiologicalProcess | renal tubule morphogenesis | 1.10e-03 | 93 | 45 | 3 | GO:0061333 | |
| GeneOntologyBiologicalProcess | positive regulation of chondrocyte differentiation | 1.25e-03 | 24 | 45 | 2 | GO:0032332 | |
| GeneOntologyBiologicalProcess | dorsal/ventral pattern formation | 1.64e-03 | 107 | 45 | 3 | GO:0009953 | |
| GeneOntologyBiologicalProcess | nerve development | 1.73e-03 | 109 | 45 | 3 | GO:0021675 | |
| GeneOntologyBiologicalProcess | regulation of animal organ morphogenesis | 1.78e-03 | 110 | 45 | 3 | GO:2000027 | |
| GeneOntologyBiologicalProcess | nephron tubule development | 1.78e-03 | 110 | 45 | 3 | GO:0072080 | |
| GeneOntologyBiologicalProcess | negative regulation of transcription by RNA polymerase II | 1.80e-03 | 1053 | 45 | 8 | GO:0000122 | |
| GeneOntologyBiologicalProcess | kidney morphogenesis | 1.83e-03 | 111 | 45 | 3 | GO:0060993 | |
| GeneOntologyBiologicalProcess | sexual reproduction | 1.83e-03 | 1312 | 45 | 9 | GO:0019953 | |
| GeneOntologyBiologicalProcess | renal tubule development | 2.07e-03 | 116 | 45 | 3 | GO:0061326 | |
| GeneOntologyBiologicalProcess | morphogenesis of an epithelium | 2.15e-03 | 619 | 45 | 6 | GO:0002009 | |
| GeneOntologyBiologicalProcess | cranial nerve morphogenesis | 2.21e-03 | 32 | 45 | 2 | GO:0021602 | |
| GeneOntologyBiologicalProcess | brain development | 2.41e-03 | 859 | 45 | 7 | GO:0007420 | |
| GeneOntologyBiologicalProcess | motor neuron axon guidance | 2.65e-03 | 35 | 45 | 2 | GO:0008045 | |
| GeneOntologyBiologicalProcess | nephron epithelium development | 2.74e-03 | 128 | 45 | 3 | GO:0072009 | |
| GeneOntologyBiologicalProcess | positive regulation of cartilage development | 2.80e-03 | 36 | 45 | 2 | GO:0061036 | |
| GeneOntologyBiologicalProcess | embryonic forelimb morphogenesis | 2.95e-03 | 37 | 45 | 2 | GO:0035115 | |
| GeneOntologyBiologicalProcess | head development | 3.52e-03 | 919 | 45 | 7 | GO:0060322 | |
| GeneOntologyBiologicalProcess | chondrocyte development | 3.62e-03 | 41 | 45 | 2 | GO:0002063 | |
| GeneOntologyCellularComponent | chromatin | HOXB1 HOXC11 HOXD1 HOXD11 HOXD12 MNX1 DBX2 PDX1 CHD8 EVX1 PAWR DLX2 IRX6 IRX2 EVX2 MEOX1 HOXA1 | 6.26e-09 | 1480 | 46 | 17 | GO:0000785 |
| MousePheno | abnormal carpal bone morphology | 2.57e-06 | 36 | 38 | 4 | MP:0000554 | |
| MousePheno | short metacarpal bones | 6.61e-06 | 14 | 38 | 3 | MP:0004634 | |
| MousePheno | facial paralysis | 2.15e-05 | 3 | 38 | 2 | MP:0030141 | |
| MousePheno | absent facial nuclei | 2.15e-05 | 3 | 38 | 2 | MP:0000843 | |
| MousePheno | absent facial nerve | 4.30e-05 | 4 | 38 | 2 | MP:0004561 | |
| MousePheno | increased lumbar vertebrae number | 4.30e-05 | 4 | 38 | 2 | MP:0004650 | |
| MousePheno | abnormal radius morphology | 6.97e-05 | 82 | 38 | 4 | MP:0000552 | |
| MousePheno | small facial motor nucleus | 7.16e-05 | 5 | 38 | 2 | MP:0000910 | |
| MousePheno | abnormal ulna morphology | 7.66e-05 | 84 | 38 | 4 | MP:0005108 | |
| MousePheno | abnormal facial nerve morphology | 9.56e-05 | 33 | 38 | 3 | MP:0001071 | |
| MousePheno | abnormal rhombomere 4 morphology | 1.07e-04 | 6 | 38 | 2 | MP:0012796 | |
| MousePheno | abnormal metacarpal bone morphology | 1.35e-04 | 37 | 38 | 3 | MP:0003073 | |
| MousePheno | abnormal forelimb zeugopod morphology | 1.63e-04 | 102 | 38 | 4 | MP:0003855 | |
| MousePheno | increased presacral vertebrae number | 5.51e-04 | 13 | 38 | 2 | MP:0000464 | |
| MousePheno | right aortic arch | 5.70e-04 | 60 | 38 | 3 | MP:0004158 | |
| MousePheno | abnormal facial motor nucleus morphology | 6.41e-04 | 14 | 38 | 2 | MP:0000909 | |
| MousePheno | fused carpal bones | 6.41e-04 | 14 | 38 | 2 | MP:0008915 | |
| MousePheno | abnormal pancreatic delta cell morphology | 8.43e-04 | 16 | 38 | 2 | MP:0005218 | |
| MousePheno | sacral vertebral transformation | 8.43e-04 | 16 | 38 | 2 | MP:0004617 | |
| MousePheno | small middle ear ossicles | 9.54e-04 | 17 | 38 | 2 | MP:0030123 | |
| MousePheno | abnormal rhombomere morphology | 9.54e-04 | 17 | 38 | 2 | MP:0000933 | |
| Domain | Homeobox_metazoa | HOXA11 HOXB1 HOXC11 HOXC12 HOXD1 HOXD11 HOXD12 MNX1 DBX2 PDX1 EVX1 DLX2 EVX2 MEOX1 HOXA1 | 2.34e-24 | 90 | 46 | 15 | IPR020479 |
| Domain | Homeobox_CS | HOXA11 HOXB1 HOXC11 HOXC12 HOXD1 HOXD11 HOXD12 MNX1 DBX2 PDX1 EVX1 DLX2 IRX6 IRX2 EVX2 MEOX1 HOXA1 | 6.03e-23 | 186 | 46 | 17 | IPR017970 |
| Domain | - | HOXA11 HOXB1 MYPOP HOXC11 HOXC12 HOXD1 HOXD11 HOXD12 MNX1 DBX2 PDX1 EVX1 DLX2 IRX6 IRX2 EVX2 MEOX1 HOXA1 | 1.98e-21 | 283 | 46 | 18 | 1.10.10.60 |
| Domain | Homeobox | HOXA11 HOXB1 HOXC11 HOXC12 HOXD1 HOXD11 HOXD12 MNX1 DBX2 PDX1 EVX1 DLX2 IRX6 IRX2 EVX2 MEOX1 HOXA1 | 3.26e-21 | 234 | 46 | 17 | PF00046 |
| Domain | HOMEOBOX_1 | HOXA11 HOXB1 HOXC11 HOXC12 HOXD1 HOXD11 HOXD12 MNX1 DBX2 PDX1 EVX1 DLX2 IRX6 IRX2 EVX2 MEOX1 HOXA1 | 3.77e-21 | 236 | 46 | 17 | PS00027 |
| Domain | HOX | HOXA11 HOXB1 HOXC11 HOXC12 HOXD1 HOXD11 HOXD12 MNX1 DBX2 PDX1 EVX1 DLX2 IRX6 IRX2 EVX2 MEOX1 HOXA1 | 4.06e-21 | 237 | 46 | 17 | SM00389 |
| Domain | Homeobox_dom | HOXA11 HOXB1 HOXC11 HOXC12 HOXD1 HOXD11 HOXD12 MNX1 DBX2 PDX1 EVX1 DLX2 IRX6 IRX2 EVX2 MEOX1 HOXA1 | 4.69e-21 | 239 | 46 | 17 | IPR001356 |
| Domain | HOMEOBOX_2 | HOXA11 HOXB1 HOXC11 HOXC12 HOXD1 HOXD11 HOXD12 MNX1 DBX2 PDX1 EVX1 DLX2 IRX6 IRX2 EVX2 MEOX1 HOXA1 | 4.69e-21 | 239 | 46 | 17 | PS50071 |
| Domain | Homeodomain-like | HOXA11 HOXB1 MYPOP HOXC11 HOXC12 HOXD1 HOXD11 HOXD12 MNX1 DBX2 PDX1 EVX1 DLX2 IRX6 IRX2 EVX2 MEOX1 HOXA1 | 3.56e-20 | 332 | 46 | 18 | IPR009057 |
| Domain | HTH_motif | 3.28e-10 | 69 | 46 | 7 | IPR000047 | |
| Domain | DUF3528 | 1.40e-08 | 3 | 46 | 3 | PF12045 | |
| Domain | DUF3528 | 1.40e-08 | 3 | 46 | 3 | IPR021918 | |
| Domain | ANTENNAPEDIA | 3.30e-07 | 24 | 46 | 4 | PS00032 | |
| Domain | IRO | 8.85e-05 | 6 | 46 | 2 | SM00548 | |
| Domain | Iroquois_homeo | 8.85e-05 | 6 | 46 | 2 | IPR003893 | |
| Domain | Homeobox_KN | 7.88e-04 | 17 | 46 | 2 | PF05920 | |
| Domain | Homeobox_KN_domain | 7.88e-04 | 17 | 46 | 2 | IPR008422 | |
| Pathway | REACTOME_KIDNEY_DEVELOPMENT | 2.93e-06 | 46 | 31 | 4 | M48243 | |
| Pathway | REACTOME_FORMATION_OF_THE_URETERIC_BUD | 1.25e-05 | 21 | 31 | 3 | M48244 | |
| Pubmed | A census of human transcription factors: function, expression and evolution. | HOXA11 HOXB1 MYPOP HOXC11 HOXC12 HOXD1 HOXD11 HOXD12 MNX1 DBX2 PDX1 EVX1 DLX2 IRX6 IRX2 EVX2 MEOX1 HOXA1 | 1.45e-16 | 908 | 49 | 18 | 19274049 |
| Pubmed | 4.03e-16 | 38 | 49 | 8 | 15042701 | ||
| Pubmed | 4.03e-16 | 38 | 49 | 8 | 11857506 | ||
| Pubmed | 5.06e-16 | 39 | 49 | 8 | 33257809 | ||
| Pubmed | Quantification of Hox and surfactant protein-B transcription during murine lung development. | 6.32e-16 | 40 | 49 | 8 | 19204410 | |
| Pubmed | 1.19e-15 | 43 | 49 | 8 | 22701719 | ||
| Pubmed | 1.45e-15 | 44 | 49 | 8 | 1973146 | ||
| Pubmed | 2.57e-15 | 47 | 49 | 8 | 1358459 | ||
| Pubmed | New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice. | 4.37e-15 | 50 | 49 | 8 | 28188179 | |
| Pubmed | Impact of cytosine methylation on DNA binding specificities of human transcription factors. | HOXA11 HOXB1 HOXC11 HOXC12 HOXD1 HOXD11 HOXD12 MNX1 PDX1 EVX1 DLX2 EVX2 MEOX1 HOXA1 | 1.82e-14 | 544 | 49 | 14 | 28473536 |
| Pubmed | 1.53e-13 | 41 | 49 | 7 | 32479258 | ||
| Pubmed | 2.64e-12 | 29 | 49 | 6 | 2574852 | ||
| Pubmed | 3.54e-12 | 12 | 49 | 5 | 8978061 | ||
| Pubmed | 5.54e-12 | 118 | 49 | 8 | 16971476 | ||
| Pubmed | 8.92e-12 | 14 | 49 | 5 | 9342041 | ||
| Pubmed | Multiple enhancers regulate Hoxd genes and the Hotdog LncRNA during cecum budding. | 2.75e-11 | 17 | 49 | 5 | 24075990 | |
| Pubmed | Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs. | 1.16e-10 | 22 | 49 | 5 | 26283362 | |
| Pubmed | 2.42e-10 | 8 | 49 | 4 | 11511348 | ||
| Pubmed | Reshuffling genomic landscapes to study the regulatory evolution of Hox gene clusters. | 4.36e-10 | 9 | 49 | 4 | 21670281 | |
| Pubmed | Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1. | 7.25e-10 | 10 | 49 | 4 | 11060466 | |
| Pubmed | Structural and functional differences in the long non-coding RNA hotair in mouse and human. | 7.25e-10 | 10 | 49 | 4 | 21637793 | |
| Pubmed | 7.25e-10 | 10 | 49 | 4 | 11544178 | ||
| Pubmed | Targeted disruption of Hotair leads to homeotic transformation and gene derepression. | 7.25e-10 | 10 | 49 | 4 | 24075995 | |
| Pubmed | 1.71e-09 | 12 | 49 | 4 | 18519639 | ||
| Pubmed | An atlas of combinatorial transcriptional regulation in mouse and man. | HOXA11 HOXB1 HOXC11 HOXC12 HOXD1 HOXD12 KDM2B PAWR DLX2 IRX6 MEOX1 HOXA1 | 2.40e-09 | 877 | 49 | 12 | 20211142 |
| Pubmed | 2.46e-09 | 13 | 49 | 4 | 35017475 | ||
| Pubmed | Hoxa11 and Hoxd11 regulate branching morphogenesis of the ureteric bud in the developing kidney. | 3.44e-09 | 14 | 49 | 4 | 11493536 | |
| Pubmed | Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. | 4.69e-09 | 15 | 49 | 4 | 19938081 | |
| Pubmed | Distal Limb Patterning Requires Modulation of cis-Regulatory Activities by HOX13. | 6.25e-09 | 16 | 49 | 4 | 27974206 | |
| Pubmed | 9.54e-09 | 191 | 49 | 7 | 24146773 | ||
| Pubmed | 1.05e-08 | 18 | 49 | 4 | 12874134 | ||
| Pubmed | 1.05e-08 | 4 | 49 | 3 | 7915637 | ||
| Pubmed | 1.33e-08 | 19 | 49 | 4 | 11567614 | ||
| Pubmed | Hox gene expression in limbs: colinearity by opposite regulatory controls. | 2.62e-08 | 5 | 49 | 3 | 10075849 | |
| Pubmed | A global control region defines a chromosomal regulatory landscape containing the HoxD cluster. | 2.62e-08 | 5 | 49 | 3 | 12732147 | |
| Pubmed | 2.62e-08 | 5 | 49 | 3 | 9521905 | ||
| Pubmed | Generation and expression of a Hoxa11eGFP targeted allele in mice. | 2.62e-08 | 5 | 49 | 3 | 18942146 | |
| Pubmed | 2.62e-08 | 5 | 49 | 3 | 34010606 | ||
| Pubmed | An enhancer-titration effect induces digit-specific regulatory alleles of the HoxD cluster. | 2.62e-08 | 5 | 49 | 3 | 12679098 | |
| Pubmed | Synpolydactyly in mice with a targeted deficiency in the HoxD complex. | 2.62e-08 | 5 | 49 | 3 | 8900279 | |
| Pubmed | 2.62e-08 | 5 | 49 | 3 | 9391088 | ||
| Pubmed | 2.62e-08 | 5 | 49 | 3 | 12217321 | ||
| Pubmed | 5.08e-08 | 26 | 49 | 4 | 8646877 | ||
| Pubmed | The winged helix transcription factor Fkh10 is required for normal development of the inner ear. | 5.24e-08 | 6 | 49 | 3 | 9843211 | |
| Pubmed | 5.24e-08 | 6 | 49 | 3 | 9733096 | ||
| Pubmed | 5.24e-08 | 6 | 49 | 3 | 27977683 | ||
| Pubmed | Rnf220 cooperates with Zc4h2 to specify spinal progenitor domains. | 8.05e-08 | 29 | 49 | 4 | 30177510 | |
| Pubmed | 8.55e-08 | 263 | 49 | 7 | 20932939 | ||
| Pubmed | A dual role for Hox genes in limb anterior-posterior asymmetry. | 9.16e-08 | 7 | 49 | 3 | 15192229 | |
| Pubmed | 9.16e-08 | 7 | 49 | 3 | 19716816 | ||
| Pubmed | 9.16e-08 | 7 | 49 | 3 | 21195707 | ||
| Pubmed | Mesomelic dysplasias associated with the HOXD locus are caused by regulatory reallocations. | 9.16e-08 | 7 | 49 | 3 | 34408147 | |
| Pubmed | Ectopic Hoxa-1 induces rhombomere transformation in mouse hindbrain. | 9.16e-08 | 7 | 49 | 3 | 7956823 | |
| Pubmed | Ndrg2 regulates vertebral specification in differentiating somites. | 1.21e-07 | 32 | 49 | 4 | 22819676 | |
| Pubmed | 1.46e-07 | 8 | 49 | 3 | 20978074 | ||
| Pubmed | Modeling Hox gene regulation in digits: reverse collinearity and the molecular origin of thumbness. | 1.46e-07 | 8 | 49 | 3 | 18245448 | |
| Pubmed | Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton. | 1.46e-07 | 8 | 49 | 3 | 12869760 | |
| Pubmed | 1.46e-07 | 8 | 49 | 3 | 10364522 | ||
| Pubmed | 1.46e-07 | 8 | 49 | 3 | 1688181 | ||
| Pubmed | Hox11 paralogous genes are essential for metanephric kidney induction. | 1.46e-07 | 8 | 49 | 3 | 12050119 | |
| Pubmed | 1.46e-07 | 8 | 49 | 3 | 10319820 | ||
| Pubmed | Tetrapod axial evolution and developmental constraints; Empirical underpinning by a mouse model. | 1.46e-07 | 8 | 49 | 3 | 26238020 | |
| Pubmed | Control of Hoxd genes' collinearity during early limb development. | 1.46e-07 | 8 | 49 | 3 | 16399081 | |
| Pubmed | A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly. | 1.46e-07 | 8 | 49 | 3 | 11778160 | |
| Pubmed | A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus. | 1.46e-07 | 8 | 49 | 3 | 27198226 | |
| Pubmed | AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. | 1.46e-07 | 8 | 49 | 3 | 9343407 | |
| Pubmed | 2.19e-07 | 9 | 49 | 3 | 8102800 | ||
| Pubmed | A regulatory archipelago controls Hox genes transcription in digits. | 2.19e-07 | 9 | 49 | 3 | 22118467 | |
| Pubmed | Anterior-posterior differences in HoxD chromatin topology in limb development. | 2.19e-07 | 9 | 49 | 3 | 22872084 | |
| Pubmed | Development of the vertebrate ear: insights from knockouts and mutants. | 3.13e-07 | 10 | 49 | 3 | 10354604 | |
| Pubmed | Molecular Analysis of the HOXA2-Dependent Degradation of RCHY1. | 3.13e-07 | 10 | 49 | 3 | 26496426 | |
| Pubmed | 3.13e-07 | 10 | 49 | 3 | 16322559 | ||
| Pubmed | 4.30e-07 | 11 | 49 | 3 | 14597572 | ||
| Pubmed | Orientation of the Hoxa complex and placement of the Hd locus distal to Hoxa2 on mouse chromosome 6. | 5.73e-07 | 12 | 49 | 3 | 8833244 | |
| Pubmed | 5.73e-07 | 12 | 49 | 3 | 10529420 | ||
| Pubmed | 5.73e-07 | 12 | 49 | 3 | 26633036 | ||
| Pubmed | ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling. | 5.73e-07 | 12 | 49 | 3 | 31336385 | |
| Pubmed | 5.73e-07 | 709 | 49 | 9 | 22988430 | ||
| Pubmed | Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity. | 7.03e-07 | 49 | 49 | 4 | 35315772 | |
| Pubmed | Hox gene function in vertebrate gut morphogenesis: the case of the caecum. | 7.44e-07 | 13 | 49 | 3 | 17942481 | |
| Pubmed | 9.46e-07 | 14 | 49 | 3 | 9834182 | ||
| Pubmed | 9.46e-07 | 14 | 49 | 3 | 18485340 | ||
| Pubmed | 9.46e-07 | 14 | 49 | 3 | 1348361 | ||
| Pubmed | A distinct Hox code for the branchial region of the vertebrate head. | 1.18e-06 | 15 | 49 | 3 | 1682814 | |
| Pubmed | 1.18e-06 | 15 | 49 | 3 | 9226455 | ||
| Pubmed | Hoxd and Gli3 interactions modulate digit number in the amniote limb. | 1.18e-06 | 15 | 49 | 3 | 17714700 | |
| Pubmed | Loss of the Tg737 protein results in skeletal patterning defects. | 1.45e-06 | 16 | 49 | 3 | 12701101 | |
| Pubmed | 1.45e-06 | 16 | 49 | 3 | 11239429 | ||
| Pubmed | 1.45e-06 | 16 | 49 | 3 | 22219351 | ||
| Pubmed | A Hox Code Defines Spinocerebellar Neuron Subtype Regionalization. | 1.45e-06 | 16 | 49 | 3 | 31747609 | |
| Pubmed | 1.45e-06 | 16 | 49 | 3 | 12431380 | ||
| Pubmed | 1.45e-06 | 16 | 49 | 3 | 21795281 | ||
| Pubmed | 1.76e-06 | 17 | 49 | 3 | 17626057 | ||
| Pubmed | Sall genes regulate region-specific morphogenesis in the mouse limb by modulating Hox activities. | 1.76e-06 | 17 | 49 | 3 | 19168674 | |
| Pubmed | 1.94e-06 | 2 | 49 | 2 | 11278854 | ||
| Pubmed | 1.94e-06 | 2 | 49 | 2 | 16890163 | ||
| Pubmed | 1.94e-06 | 2 | 49 | 2 | 1684419 | ||
| Pubmed | Fitness Assays Reveal Incomplete Functional Redundancy of the HoxA1 and HoxB1 Paralogs of Mice. | 1.94e-06 | 2 | 49 | 2 | 26447130 | |
| Pubmed | A region of the human HOXD cluster that confers polycomb-group responsiveness. | 1.94e-06 | 2 | 49 | 2 | 20085705 | |
| Pubmed | Mouse fitness measures reveal incomplete functional redundancy of Hox paralogous group 1 proteins. | 1.94e-06 | 2 | 49 | 2 | 28380068 | |
| Interaction | MEIS1 interactions | 2.47e-09 | 52 | 48 | 6 | int:MEIS1 | |
| Interaction | TLX2 interactions | 2.17e-05 | 142 | 48 | 5 | int:TLX2 | |
| Interaction | PBX1 interactions | 4.98e-05 | 85 | 48 | 4 | int:PBX1 | |
| Interaction | IRF4 interactions | 4.98e-05 | 85 | 48 | 4 | int:IRF4 | |
| Interaction | HOXD1 interactions | 5.53e-05 | 5 | 48 | 2 | int:HOXD1 | |
| Cytoband | 2q31.1 | 3.25e-08 | 84 | 49 | 5 | 2q31.1 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr2q31 | 3.80e-08 | 178 | 49 | 6 | chr2q31 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr7p15 | 1.77e-04 | 101 | 49 | 3 | chr7p15 | |
| Cytoband | 7p15.2 | 9.80e-04 | 43 | 49 | 2 | 7p15.2 | |
| GeneFamily | HOXL subclass homeoboxes | HOXA11 HOXB1 HOXC11 HOXC12 HOXD1 HOXD11 HOXD12 MNX1 PDX1 EVX1 EVX2 MEOX1 HOXA1 | 1.18e-26 | 52 | 29 | 13 | 518 |
| GeneFamily | TALE class homeoboxes and pseudogenes | 7.88e-04 | 26 | 29 | 2 | 526 | |
| GeneFamily | NKL subclass homeoboxes and pseudogenes | 5.15e-03 | 67 | 29 | 2 | 519 | |
| Coexpression | MEISSNER_BRAIN_HCP_WITH_H3K27ME3 | HOXA11 HOXC11 HOXC12 HOXD1 HOXD11 HOXD12 MNX1 PDX1 EVX1 IRX6 IRX2 | 1.98e-12 | 272 | 48 | 11 | M1938 |
| Coexpression | MEISSNER_BRAIN_HCP_WITH_H3K27ME3 | HOXA11 HOXC11 HOXC12 HOXD1 HOXD11 HOXD12 MNX1 PDX1 EVX1 IRX6 IRX2 | 2.92e-12 | 282 | 48 | 11 | MM822 |
| Coexpression | MEISSNER_NPC_HCP_WITH_H3K27ME3 | 3.38e-07 | 79 | 48 | 5 | M1932 | |
| Coexpression | MEISSNER_NPC_HCP_WITH_H3K27ME3 | 3.60e-07 | 80 | 48 | 5 | MM817 | |
| Coexpression | GSE27092_WT_VS_HDAC7_PHOSPHO_DEFICIENT_CD8_TCELL_DN | 1.72e-06 | 200 | 48 | 6 | M8204 | |
| Coexpression | BENPORATH_EED_TARGETS | HOXB1 HOXC11 HOXC12 HOXD1 HOXD11 HOXD12 MNX1 PDX1 EVX1 DLX2 HOXA1 | 2.54e-06 | 1059 | 48 | 11 | M7617 |
| Coexpression | BENPORATH_SUZ12_TARGETS | 1.47e-05 | 1035 | 48 | 10 | M9898 | |
| Coexpression | BENPORATH_PRC2_TARGETS | 2.15e-05 | 650 | 48 | 8 | M8448 | |
| Coexpression | GRESHOCK_CANCER_COPY_NUMBER_UP | 2.65e-05 | 323 | 48 | 6 | M9150 | |
| Coexpression | BENPORATH_ES_WITH_H3K27ME3 | 2.79e-05 | 1115 | 48 | 10 | M10371 | |
| Coexpression | DESCARTES_ORGANOGENESIS_LIMB_MESENCHYME | 3.03e-05 | 33 | 48 | 3 | MM3669 | |
| Coexpression | MIKKELSEN_NPC_HCP_WITH_H3K27ME3 | 3.83e-05 | 345 | 48 | 6 | M2009 | |
| Coexpression | MIKKELSEN_NPC_HCP_WITH_H3K27ME3 | 3.96e-05 | 347 | 48 | 6 | MM860 | |
| Coexpression | NIKOLSKY_BREAST_CANCER_7P15_AMPLICON | 1.79e-04 | 11 | 48 | 2 | M18241 | |
| Coexpression | ZHOU_PANCREATIC_EXOCRINE_PROGENITOR | 1.79e-04 | 11 | 48 | 2 | MM1245 | |
| Coexpression | ZHOU_PANCREATIC_EXOCRINE_PROGENITOR | 1.79e-04 | 11 | 48 | 2 | M1860 | |
| Coexpression | SHIN_B_CELL_LYMPHOMA_CLUSTER_1 | 2.53e-04 | 13 | 48 | 2 | M1383 | |
| CoexpressionAtlas | gudmap_RNAseq_e11.5_Ureteric_stalks_2500_K2 | 3.57e-06 | 441 | 45 | 8 | gudmap_RNAseq_e11.5_Ureteric_stalks_2500_K2 | |
| CoexpressionAtlas | kidney_P1_CapMes_Crym_k-means-cluster#4_top-relative-expression-ranked_100 | 1.03e-04 | 43 | 45 | 3 | gudmap_kidney_P1_CapMes_Crym_k4_100 | |
| CoexpressionAtlas | DevelopingKidney_e11.5_metaneph mesench_emap-3843_k-means-cluster#1_top-relative-expression-ranked_200 | 1.72e-04 | 51 | 45 | 3 | gudmap_developingKidney_e11.5_metaneph mesench_200_k1 | |
| CoexpressionAtlas | DevelopingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_emap-30875_top-relative-expression-ranked_1000 | 2.45e-04 | 800 | 45 | 8 | gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_1000 | |
| CoexpressionAtlas | DevelopingKidney_e11.5_metaneph mesench_emap-3843_top-relative-expression-ranked_500 | 2.81e-04 | 431 | 45 | 6 | gudmap_developingKidney_e11.5_metaneph mesench_500 | |
| CoexpressionAtlas | DevelopingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_emap-30875_k-means-cluster#3_top-relative-expression-ranked_1000 | 2.86e-04 | 276 | 45 | 5 | gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_1000_k3 | |
| CoexpressionAtlas | kidney_P1_CapMes_Crym_top-relative-expression-ranked_100 | 3.08e-04 | 62 | 45 | 3 | gudmap_kidney_P1_CapMes_Crym_100 | |
| CoexpressionAtlas | kidney_P0_CapMes_Crym_top-relative-expression-ranked_100 | 3.23e-04 | 63 | 45 | 3 | gudmap_kidney_P0_CapMes_Crym_100 | |
| CoexpressionAtlas | DevelopingKidney_e11.5_metaneph mesench_emap-3843_top-relative-expression-ranked_200 | 3.64e-04 | 160 | 45 | 4 | gudmap_developingKidney_e11.5_metaneph mesench_200 | |
| CoexpressionAtlas | DevelopingKidney_e11.5_metaneph mesench_emap-3843_top-relative-expression-ranked_1000 | 3.69e-04 | 850 | 45 | 8 | gudmap_developingKidney_e11.5_metaneph mesench_1000 | |
| ToppCell | CV-Mild-6|Mild / Virus stimulation, Condition and Cluster | 1.26e-06 | 175 | 48 | 5 | c4d530dbb37942427c9cd0a1533faeb6a3a45381 | |
| ToppCell | Substantia_nigra-Macroglia-POLYDENDROCYTE-P3-Tnr|Substantia_nigra / BrainAtlas - Mouse McCarroll V32 | 2.38e-06 | 87 | 48 | 4 | 8ca87e4a332ef6f035b13e80dcc0110f32172c9a | |
| ToppCell | Substantia_nigra-Macroglia-POLYDENDROCYTE-P3|Substantia_nigra / BrainAtlas - Mouse McCarroll V32 | 2.38e-06 | 87 | 48 | 4 | 4ec3a9489981ed69061c1ca363271edf6a3635d2 | |
| ToppCell | TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular-5|TCGA-Stomach / Sample_Type by Project: Shred V9 | 8.84e-06 | 121 | 48 | 4 | 392700c5032b83d4d4e191fea9bcd170e4567b9d | |
| Drug | glyphosate | 5.83e-06 | 215 | 48 | 6 | CID000003496 | |
| Disease | Limb Deformities, Congenital | 2.37e-06 | 17 | 46 | 3 | C0206762 | |
| Disease | Congenital neurologic anomalies | 1.06e-04 | 10 | 46 | 2 | C0497552 | |
| Disease | Cranioschisis | 1.06e-04 | 10 | 46 | 2 | C0265541 | |
| Disease | Neonatal diabetes mellitus | 6.97e-04 | 25 | 46 | 2 | C0158981 | |
| Disease | Autistic Disorder | 7.29e-04 | 261 | 46 | 4 | C0004352 | |
| Disease | fasting blood glucose measurement | 1.04e-03 | 287 | 46 | 4 | EFO_0004465 | |
| Disease | unipolar depression, systolic blood pressure | 1.29e-03 | 34 | 46 | 2 | EFO_0003761, EFO_0006335 | |
| Disease | Craniofacial Abnormalities | 1.86e-03 | 156 | 46 | 3 | C0376634 | |
| Disease | urinary bladder carcinoma | 2.46e-03 | 47 | 46 | 2 | MONDO_0004986 | |
| Disease | systemic lupus erythematosus, COVID-19 | 3.72e-03 | 58 | 46 | 2 | MONDO_0007915, MONDO_0100096 | |
| Disease | Endometrial Neoplasms | 3.72e-03 | 58 | 46 | 2 | C0014170 | |
| Disease | BMI-adjusted waist-hip ratio, physical activity measurement | 5.22e-03 | 69 | 46 | 2 | EFO_0007788, EFO_0008002 | |
| Disease | Endometrial Carcinoma | 5.67e-03 | 72 | 46 | 2 | C0476089 | |
| Disease | smoking behavior, BMI-adjusted waist-hip ratio | 8.00e-03 | 86 | 46 | 2 | EFO_0004318, EFO_0007788 | |
| Disease | Kidney Diseases | 8.36e-03 | 88 | 46 | 2 | C0022658 |
| Peptide | Gene | Start | Entry |
|---|---|---|---|
| YMEDRRKQKWQRCKK | 2356 | Q9HCK8 | |
| KSKKREERWMRASKR | 1336 | Q7Z7A1 | |
| SWQRKMKERQERKLA | 266 | Q9H6F5 | |
| FRKKKREQELREMAW | 281 | O00481 | |
| MVKVNFQRKKWRTED | 706 | Q99965 | |
| TIKVWFQNRRMKDKR | 226 | P49640 | |
| TIKVWFQNRRMKDKR | 231 | Q03828 | |
| VKIWFQNRRSKFKKM | 196 | Q07687 | |
| EEWKAKREKMRAKQN | 21 | Q96IZ0 | |
| WFANARRRLKKENKM | 196 | P78412 | |
| KVWFQNRRMKWKRVK | 216 | P50221 | |
| QQVKIWFQNRRMKKK | 256 | P31275 | |
| RQKYCKEWRKRKRMA | 166 | Q9P2W1 | |
| WFQNRRMKQKKRERE | 276 | Q9GZZ0 | |
| KIWFQNRRMKWKRSK | 286 | P50219 | |
| NRRMKWKRSKKAKEQ | 291 | P50219 | |
| WMNQRQRKRLKAKRE | 96 | Q9BRT6 | |
| DFDEKTMQKARRKQW | 356 | P55107 | |
| EWRRKEKENARKKME | 401 | Q9UL16 | |
| NRRMKWKKEEDKKRG | 196 | P52945 | |
| MKWVRTDKENRVKNL | 201 | O60662 | |
| KIREQEKKMWRQEEK | 431 | Q8N7Z2 | |
| KKIRKQEEKMWRQEE | 286 | Q8N9W4 | |
| WFQNRRMKQKKREKE | 276 | P49639 | |
| KIWFQNRRMKEKKIN | 286 | P31270 | |
| ANARRRLKKENKMTW | 166 | Q9BZI1 | |
| QKKQNAKRFKRRWMV | 236 | Q9UMY1 | |
| RREQQWMEKKKRQEE | 346 | Q5T2D3 | |
| RLWLKKKHEEQMKER | 416 | Q5TID7 | |
| QVKIWFQNRRMKQKK | 246 | P14653 | |
| RKKRRSWKNAEDRMA | 866 | Q8NHM5 | |
| KERREIQAWMKRKRK | 2891 | Q9H799 | |
| RSWEQKLEEMRKKEK | 96 | Q16543 | |
| NRRMKWRNSKEKEVL | 236 | Q6ZNG2 | |
| KIWFQNRRMKEKKLN | 311 | P31277 | |
| VKIWFQNRRMKKKRV | 246 | P35452 | |
| VKIWFQNRRMKEKKL | 276 | O43248 | |
| VEAIERMKQKEWRQK | 481 | Q502W7 | |
| RMKQKEWRQKFRDEK | 486 | Q502W7 | |
| EWRQKFRDEKMKEKQ | 491 | Q502W7 | |
| VKEIRKEKQQRKMEW | 166 | A0A1B0GTZ2 | |
| MNRKWEAKLKQIEER | 1 | Q96LW4 | |
| REEWDRKKKMKVKRE | 176 | P82675 | |
| KKWVEEMREKQQAAR | 61 | Q9NVN8 | |
| RMLKRFRQEKAVWIK | 1716 | Q14690 | |
| REEKERRKKQQWEIM | 371 | Q86UC2 | |
| WEKDIKQKDMELRRQ | 31 | Q9H6T3 | |
| KRRKSMSRWLNKQED | 101 | A6NJ88 | |
| RLQMRRFKKNWKCDL | 1266 | Q8N9V7 | |
| YREDWKSKEMKVRQR | 461 | P11387 | |
| KRKRSRWNQDTMEQK | 16 | Q15637 | |
| VQKRWNDFKRRTKEK | 76 | Q86VE0 |