Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium ion binding	CRELD2 HSPG2 PEF1 HEG1 LTBP3 HRNR CUBN FAT3	4.49e-05	749	36	8	GO:0005509
HumanPheno	Elbow dislocation	HSPG2 ARID1B GLI3 PITX1	4.39e-05	84	13	4	HP:0003042
HumanPheno	Upper extremity joint dislocation	HSPG2 ARID1B GLI3 PITX1	7.44e-05	96	13	4	HP:0030310
HumanPheno	Bifid epiglottis	FOXE1 GLI3	1.25e-04	7	13	2	HP:0010564
HumanPheno	Absent tibia	GLI3 PITX1	1.67e-04	8	13	2	HP:0009556
HumanPheno	Distichiasis	HSPG2 FOXC2	1.67e-04	8	13	2	HP:0009743
HumanPheno	Multiple rows of eyelashes	HSPG2 FOXC2	1.67e-04	8	13	2	HP:0008496
MousePheno	embryonic lethality during organogenesis, incomplete penetrance	HSPG2 HMGCL HEG1 GLI3 PITX1 TNRC6A FOXC2	2.45e-06	268	33	7	MP:0011108
MousePheno	abnormal orbit morphology	LTBP3 GLI3 FOXC2	9.55e-06	18	33	3	MP:0010030
MousePheno	prenatal lethality prior to heart atrial septation, incomplete penetrance	HSPG2 HMGCL HEG1 GLI3 PITX1 TNRC6A FOXC2	3.92e-05	410	33	7	MP:0031660
MousePheno	embryonic lethality, incomplete penetrance	HSPG2 HMGCL HEG1 GLI3 PITX1 TNRC6A FOXC2	3.92e-05	410	33	7	MP:0011102
MousePheno	abnormal middle ear morphology	HSPG2 PITX1 HAPLN1 FOXC2	6.21e-05	92	33	4	MP:0000049
MousePheno	abnormal sphenoid bone morphology	HSPG2 LTBP3 GLI3 FOXC2	7.04e-05	95	33	4	MP:0000104
MousePheno	abnormal long bone metaphysis morphology	HSPG2 LTBP3 HAPLN1	1.03e-04	39	33	3	MP:0000133
MousePheno	increased width of hypertrophic chondrocyte zone	HSPG2 LTBP3 PITX1	1.03e-04	39	33	3	MP:0003408
MousePheno	flat face	HSPG2 HAPLN1	1.13e-04	7	33	2	MP:0012175
MousePheno	increased diameter of humerus	HSPG2 GLI3	1.13e-04	7	33	2	MP:0008160
MousePheno	abnormal cartilage morphology	HSPG2 LTBP3 GLI3 PITX1 HAPLN1 FOXC2	1.18e-04	336	33	6	MP:0000163
MousePheno	abnormal Meckel's cartilage morphology	PITX1 HAPLN1 FOXC2	1.20e-04	41	33	3	MP:0005587
MousePheno	abnormal long bone hypertrophic chondrocyte zone	HSPG2 LTBP3 PITX1 HAPLN1	1.38e-04	113	33	4	MP:0000165
MousePheno	increased curvature of hairs	FOXE1 KRT25	1.50e-04	8	33	2	MP:0000396
MousePheno	small mandible	HSPG2 PITX1 HAPLN1 FOXC2	1.53e-04	116	33	4	MP:0004592
MousePheno	abnormal basicranium morphology	LTBP3 GLI3 HAPLN1 FOXC2	1.92e-04	123	33	4	MP:0010029
MousePheno	middle ear ossicle hypoplasia	HAPLN1 FOXC2	1.93e-04	9	33	2	MP:0030124
MousePheno	abnormal jaw morphology	HSPG2 LTBP3 KLK4 GLI3 PITX1 HAPLN1 FOXC2	1.96e-04	530	33	7	MP:0000454
MousePheno	abnormal cranial cartilage morphology	PITX1 HAPLN1 FOXC2	2.18e-04	50	33	3	MP:0030464
MousePheno	short basicranium	LTBP3 HAPLN1	2.40e-04	10	33	2	MP:0030420
MousePheno	absent neurocranium	HSPG2 GLI3	2.93e-04	11	33	2	MP:0000075
MousePheno	lymphangiectasis	HEG1 FOXC2	2.93e-04	11	33	2	MP:0004038
MousePheno	abnormal middle ear ossicle morphology	PITX1 HAPLN1 FOXC2	3.05e-04	56	33	3	MP:0005105
MousePheno	abnormal basisphenoid bone morphology	LTBP3 GLI3 FOXC2	3.22e-04	57	33	3	MP:0000106
MousePheno	abnormal inner ear development	HSPG2 GLI3	3.51e-04	12	33	2	MP:0011238
MousePheno	abnormal lymph circulation	HEG1 FOXC2	3.51e-04	12	33	2	MP:0003659
MousePheno	abnormal viscerocranium morphology	HSPG2 LTBP3 KLK4 GLI3 PITX1 HAPLN1 FOXC2	3.89e-04	593	33	7	MP:0005274
MousePheno	abnormal gonial bone morphology	PITX1 FOXC2	4.15e-04	13	33	2	MP:0008380
MousePheno	abnormal craniofacial development	FOXE1 LTBP3 GLI3 PITX1 HAPLN1 FOXC2	4.20e-04	425	33	6	MP:0003935
MousePheno	abnormal ear development	HSPG2 GLI3 FOXC2	4.74e-04	65	33	3	MP:0003938
MousePheno	abnormal vertebral body morphology	HSPG2 HAPLN1 FOXC2	4.96e-04	66	33	3	MP:0000141
MousePheno	cleft palate	FOXE1 HSPG2 GLI3 PITX1 FOXC2	5.39e-04	289	33	5	MP:0000111
MousePheno	oral cleft	FOXE1 HSPG2 GLI3 PITX1 FOXC2	5.56e-04	291	33	5	MP:0021164
MousePheno	polysyndactyly	GLI3 PITX1	5.57e-04	15	33	2	MP:0004083
MousePheno	decreased tympanic ring size	PITX1 FOXC2	5.57e-04	15	33	2	MP:0006020
MousePheno	abnormal cartilage development	HSPG2 LTBP3 PITX1 HAPLN1	6.85e-04	172	33	4	MP:0000164
MousePheno	abnormal long bone epiphyseal plate morphology	HSPG2 LTBP3 PITX1 HAPLN1	6.85e-04	172	33	4	MP:0003055
MousePheno	small middle ear ossicles	HAPLN1 FOXC2	7.19e-04	17	33	2	MP:0030123
MousePheno	abnormal mandible morphology	HSPG2 PITX1 HAPLN1 FOXC2	7.47e-04	176	33	4	MP:0000458
MousePheno	embryonic lethality during organogenesis	HSPG2 HMGCL HEG1 CUBN GLI3 PITX1 TNRC6A FOXC2	7.84e-04	876	33	8	MP:0006207
MousePheno	abnormal mouth morphology	FOXE1 HSPG2 LTBP3 KLK4 GLI3 PITX1 FOXC2	8.07e-04	670	33	7	MP:0000452
MousePheno	absent middle ear ossicles	PITX1 FOXC2	8.08e-04	18	33	2	MP:0000040
MousePheno	abnormal palate morphology	FOXE1 HSPG2 GLI3 PITX1 FOXC2	8.66e-04	321	33	5	MP:0003755
MousePheno	abnormal epiphyseal plate morphology	HSPG2 LTBP3 PITX1 HAPLN1	9.00e-04	185	33	4	MP:0006395
MousePheno	abnormal otic vesicle development	GLI3 FOXC2	1.00e-03	20	33	2	MP:0006030
MousePheno	abnormal facial morphology	FOXE1 HSPG2 LTBP3 KLK4 GLI3 PITX1 HAPLN1 FOXC2	1.01e-03	910	33	8	MP:0003743
MousePheno	abnormal iris morphology	LTBP3 CUBN GLI3 FOXC2	1.03e-03	192	33	4	MP:0001322
MousePheno	abnormal cartilaginous joint morphology	HSPG2 LTBP3 GLI3	1.04e-03	85	33	3	MP:0030875
MousePheno	waved hair	FOXE1 KRT25	1.10e-03	21	33	2	MP:0000410
MousePheno	abnormal face shape	HSPG2 HAPLN1	1.10e-03	21	33	2	MP:0030071
MousePheno	osteoarthritis	HSPG2 LTBP3	1.10e-03	21	33	2	MP:0003560
MousePheno	abnormal pelvic girdle bone morphology	HSPG2 GLI3 PITX1	1.11e-03	87	33	3	MP:0004509
MousePheno	abnormal anterior uvea morphology	LTBP3 CUBN GLI3 FOXC2	1.18e-03	199	33	4	MP:0005194
MousePheno	abnormal pubis morphology	GLI3 PITX1	1.21e-03	22	33	2	MP:0004506
MousePheno	enlarged lymphatic vessel	HEG1 FOXC2	1.21e-03	22	33	2	MP:0010200
MousePheno	abnormal occipital bone morphology	HSPG2 LTBP3 FOXC2	1.43e-03	95	33	3	MP:0005269
MousePheno	abnormal radial glial cell morphology	HSPG2 GLI3	1.44e-03	24	33	2	MP:0003648
MousePheno	wide cranial sutures	HSPG2 GLI3	1.44e-03	24	33	2	MP:0030029
MousePheno	abnormal thoracic cage shape	LTBP3 CSMD1	1.44e-03	24	33	2	MP:0010099
MousePheno	prenatal lethality, incomplete penetrance	HSPG2 HMGCL HEG1 GLI3 PITX1 TNRC6A FOXC2	1.53e-03	747	33	7	MP:0011101
MousePheno	abnormal vertebrae morphology	HSPG2 LTBP3 GLI3 PITX1 HAPLN1 FOXC2	1.56e-03	546	33	6	MP:0000137
MousePheno	premature bone ossification	LTBP3 GLI3	1.70e-03	26	33	2	MP:0003416
MousePheno	short facial bone	HSPG2 LTBP3 PITX1	1.86e-03	104	33	3	MP:0030384
MousePheno	abnormal palatine bone horizontal plate morphology	GLI3 FOXC2	1.97e-03	28	33	2	MP:0004537
MousePheno	abnormal cardinal vein morphology	HSPG2 GLI3	1.97e-03	28	33	2	MP:0004783
MousePheno	short limbs	HSPG2 GLI3 PITX1	2.24e-03	111	33	3	MP:0000547
MousePheno	abnormal long bone epiphysis morphology	HSPG2 HAPLN1	2.26e-03	30	33	2	MP:0000131
MousePheno	abnormal uvea morphology	LTBP3 CUBN GLI3 FOXC2	2.38e-03	241	33	4	MP:0005197
MousePheno	abnormal multipotent stem cell morphology	GLI3 FOXC2	2.41e-03	31	33	2	MP:0002400
MousePheno	abnormal cranium morphology	HSPG2 LTBP3 KLK4 GLI3 PITX1 HAPLN1 FOXC2	2.48e-03	813	33	7	MP:0000438
MousePheno	decreased length of long bones	HSPG2 LTBP3 GLI3 PITX1 HAPLN1	2.53e-03	409	33	5	MP:0004686
MousePheno	abnormal tympanic ring morphology	PITX1 FOXC2	2.73e-03	33	33	2	MP:0000030
MousePheno	abnormal craniofacial bone morphology	HSPG2 LTBP3 KLK4 GLI3 PITX1 HAPLN1 FOXC2	2.73e-03	827	33	7	MP:0002116
MousePheno	abnormal basioccipital bone morphology	LTBP3 FOXC2	2.89e-03	34	33	2	MP:0000079
MousePheno	abnormal malleus morphology	PITX1 FOXC2	2.89e-03	34	33	2	MP:0000029
Domain	EGF_CA	CRELD2 HSPG2 HEG1 LTBP3 CUBN FAT3	1.35e-07	122	37	6	SM00179
Domain	EGF-like_Ca-bd_dom	CRELD2 HSPG2 HEG1 LTBP3 CUBN FAT3	1.49e-07	124	37	6	IPR001881
Domain	EGF_CA	CRELD2 HEG1 LTBP3 CUBN FAT3	7.14e-07	86	37	5	PF07645
Domain	EGF_Ca-bd_CS	CRELD2 HEG1 LTBP3 CUBN FAT3	1.30e-06	97	37	5	IPR018097
Domain	EGF_CA	CRELD2 HEG1 LTBP3 CUBN FAT3	1.44e-06	99	37	5	PS01187
Domain	ASX_HYDROXYL	CRELD2 HEG1 LTBP3 CUBN FAT3	1.51e-06	100	37	5	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	CRELD2 HEG1 LTBP3 CUBN FAT3	2.02e-06	106	37	5	IPR000152
Domain	EGF_3	CRELD2 HSPG2 HEG1 LTBP3 CUBN FAT3	6.24e-06	235	37	6	PS50026
Domain	EGF	CRELD2 HSPG2 HEG1 LTBP3 CUBN FAT3	6.24e-06	235	37	6	SM00181
Domain	EGF-like_dom	CRELD2 HSPG2 HEG1 LTBP3 CUBN FAT3	8.69e-06	249	37	6	IPR000742
Domain	EGF_1	CRELD2 HSPG2 HEG1 LTBP3 CUBN FAT3	9.96e-06	255	37	6	PS00022
Domain	EGF-like_CS	CRELD2 HSPG2 HEG1 LTBP3 CUBN FAT3	1.14e-05	261	37	6	IPR013032
Domain	EGF_2	CRELD2 HSPG2 HEG1 LTBP3 CUBN FAT3	1.24e-05	265	37	6	PS01186
Domain	Growth_fac_rcpt_	CRELD2 HSPG2 LTBP3 CUBN	2.50e-04	156	37	4	IPR009030
Domain	AT_hook	PRR12 BAZ2A	4.50e-04	16	37	2	PF02178
Domain	AT_hook	PRR12 BAZ2A	1.30e-03	27	37	2	SM00384
Domain	AT_hook_DNA-bd_motif	PRR12 BAZ2A	1.30e-03	27	37	2	IPR017956
Domain	HMGI/Y_DNA-bd_CS	PRR12 BAZ2A	1.71e-03	31	37	2	IPR000637
Domain	EGF	HSPG2 HEG1 CUBN	1.97e-03	126	37	3	PF00008
Domain	LAM_G_DOMAIN	HSPG2 FAT3	2.57e-03	38	37	2	PS50025
Domain	Laminin_EGF	CRELD2 HSPG2	2.57e-03	38	37	2	IPR002049
Domain	Laminin_G_2	HSPG2 FAT3	2.84e-03	40	37	2	PF02210
Domain	Keratin_I	KRT25 KRT37	3.43e-03	44	37	2	IPR002957
Domain	LamG	HSPG2 FAT3	3.43e-03	44	37	2	SM00282
Domain	TF_fork_head_CS_2	FOXE1 FOXC2	3.74e-03	46	37	2	IPR030456
Domain	TF_fork_head_CS_1	FOXE1 FOXC2	3.90e-03	47	37	2	IPR018122
Domain	FORK_HEAD_3	FOXE1 FOXC2	4.24e-03	49	37	2	PS50039
Domain	FH	FOXE1 FOXC2	4.24e-03	49	37	2	SM00339
Domain	FORK_HEAD_1	FOXE1 FOXC2	4.24e-03	49	37	2	PS00657
Domain	FORK_HEAD_2	FOXE1 FOXC2	4.24e-03	49	37	2	PS00658
Domain	Forkhead	FOXE1 FOXC2	4.24e-03	49	37	2	PF00250
Domain	Fork_head_dom	FOXE1 FOXC2	4.24e-03	49	37	2	IPR001766
Domain	CUB	CUBN CSMD1	4.24e-03	49	37	2	PF00431
Domain	CUB	CUBN CSMD1	4.41e-03	50	37	2	SM00042
Domain	-	CUBN CSMD1	4.76e-03	52	37	2	2.60.120.290
Domain	CUB	CUBN CSMD1	4.94e-03	53	37	2	PS01180
Domain	CUB_dom	CUBN CSMD1	5.69e-03	57	37	2	IPR000859
Domain	Laminin_G	HSPG2 FAT3	5.89e-03	58	37	2	IPR001791
Domain	UBA-like	USP5 TNRC6A	7.13e-03	64	37	2	IPR009060
Domain	Filament	KRT25 KRT37	8.71e-03	71	37	2	SM01391
Domain	IF	KRT25 KRT37	8.95e-03	72	37	2	PS00226
Domain	Filament	KRT25 KRT37	9.19e-03	73	37	2	PF00038
Domain	IGv	HSPG2 HAPLN1	9.68e-03	75	37	2	SM00406
Pubmed	Advances in the molecular genetics of non-syndromic polydactyly.	GLI3 PITX1	6.60e-06	4	37	2	26515020
Pubmed	Foxc2CreERT2 knock-in mice mark stage-specific Foxc2-expressing cells during mouse organogenesis.	FOXE1 FOXC2	6.60e-06	4	37	2	27783871
Pubmed	Arteries define the position of the thyroid gland during its developmental relocalisation.	FOXE1 GLI3	6.60e-06	4	37	2	16968815
Pubmed	Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.	CRELD2 TNKS LTBP3 PIM1	2.47e-05	159	37	4	24927181
Pubmed	Interaction network of human early embryonic transcription factors.	KPRP PRR12 ARID1B HRNR PITX1	3.40e-05	351	37	5	38297188
Pubmed	The BAF chromatin complex component SMARCC1 does not mediate GLI transcriptional repression of Hedgehog target genes in limb buds.	ARID1B GLI3	3.95e-05	9	37	2	37805104
Pubmed	Pitx1 determines the morphology of muscle, tendon, and bones of the hindlimb.	GLI3 PITX1	4.93e-05	10	37	2	16989801
Pubmed	Genetic analysis of the role of Alx4 in the coordination of lower body and external genitalia formation.	GLI3 PITX1	4.93e-05	10	37	2	23942202
Pubmed	Sonic hedgehog regulation of Foxf2 promotes cranial neural crest mesenchyme proliferation and is disrupted in cleft lip morphogenesis.	FOXE1 FOXC2	6.02e-05	11	37	2	28506991
Pubmed	The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain.	KRT25 KRT37	7.22e-05	12	37	2	15617563
Pubmed	Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye.	GLI3 FOXC2	7.22e-05	12	37	2	18582859
Pubmed	Motor phenotypes and molecular networks associated with germline deficiency of Ciz1.	CRELD2 PSAT1	7.22e-05	12	37	2	27163549
Pubmed	A data set of human endogenous protein ubiquitination sites.	UCK2 PSAT1	8.53e-05	13	37	2	20972266
Pubmed	Gene Regulatory and Expression Differences between Mouse and Pig Limb Buds Provide Insights into the Evolutionary Emergence of Artiodactyl Traits.	GLI3 PITX1	9.94e-05	14	37	2	32268095
Pubmed	Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.	TNKS NLRX1	9.94e-05	14	37	2	35733260
Pubmed	Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome.	HSPG2 GLI3	9.94e-05	14	37	2	19783738
Pubmed	USP25 regulates Wnt signaling by controlling the stability of tankyrases.	TNKS HRNR	1.31e-04	16	37	2	28619731
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PRR12 HSPG2 HEG1 LTBP3 NLRX1 PICK1 PITX1	1.43e-04	1105	37	7	35748872
Pubmed	Directed Bmp4 expression in neural crest cells generates a genetic model for the rare human bony syngnathia birth defect.	PITX1 FOXC2	1.48e-04	17	37	2	24785830
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	UCK2 ARID1B CSMD1 BAZ2A GLI3 FAT3 TNRC6A	1.52e-04	1116	37	7	31753913
Pubmed	Pitx1 and Pitx2 are required for development of hindlimb buds.	GLI3 PITX1	1.67e-04	18	37	2	12441290
Pubmed	Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois.	GLI3 PITX1	1.67e-04	18	37	2	12736212
Pubmed	Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the β-catenin pathway.	GLI3 PITX1	1.67e-04	18	37	2	24424161
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	PRR12 ARID1B HEG1	1.82e-04	103	37	3	10574462
Pubmed	Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia.	PITX1 FOXC2	1.86e-04	19	37	2	15107405
Pubmed	Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.	UCK2 PITX1	1.86e-04	19	37	2	23666240
Pubmed	Meta-analysis identifies four new loci associated with testicular germ cell tumor.	UCK2 LIPG	2.07e-04	20	37	2	23666239
Pubmed	Sonic hedgehog regulates growth and morphogenesis of the tooth.	GLI3 PITX1	2.28e-04	21	37	2	11044393
Pubmed	Suppressor of Fused restraint of Hedgehog activity level is critical for osteogenic proliferation and differentiation during calvarial bone development.	GLI3 FOXC2	2.28e-04	21	37	2	28794157
Pubmed	Twist plays an essential role in FGF and SHH signal transduction during mouse limb development.	GLI3 PITX1	2.28e-04	21	37	2	12142027
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	FOXE1 EGR4 GLI3 PITX1 FOXC2	2.65e-04	544	37	5	28473536
Pubmed	Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis.	HSPG2 GLI3	2.75e-04	23	37	2	30814516
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	USP5 PSAT1 ARID1B DENND1B HRNR CSMD1 PITX1	2.93e-04	1242	37	7	30973865
Pubmed	Intracisternal A-type particle elements as genetic markers: detection by repeat element viral element amplified locus-PCR.	HMGCL PIM1	2.99e-04	24	37	2	7873878
Pubmed	FOXC1 and FOXC2 regulate growth plate chondrocyte maturation towards hypertrophy in the embryonic mouse limb skeleton.	GLI3 FOXC2	2.99e-04	24	37	2	39012257
Pubmed	Delineating the early transcriptional specification of the mammalian trachea and esophagus.	FOXE1 PITX1	3.25e-04	25	37	2	32515350
Pubmed	Large-scale analysis of the human ubiquitin-related proteome.	UCK2 PSAT1 PEF1 TNRC6A	3.36e-04	313	37	4	16196087
Pubmed	Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis.	GLI3 PITX1	3.52e-04	26	37	2	23754280
Pubmed	Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.	FOXE1 GLI3 PITX1 FOXC2	4.15e-04	331	37	4	20634891
Pubmed	Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.	HSPG2 LTBP3 HAPLN1	5.07e-04	146	37	3	27068509
Pubmed	The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.	ARID1B FOXC2	5.69e-04	33	37	2	19336002
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	PRR12 PEF1 TNRC6A	5.70e-04	152	37	3	38360978
Pubmed	Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo.	GLI3 PITX1	6.05e-04	34	37	2	12086465
Pubmed	Large-scale identification of genes implicated in kidney glomerulus development and function.	HSPG2 FOXC2	6.05e-04	34	37	2	16498405
Pubmed	Human transcription factor protein interaction networks.	PRR12 HSPG2 ARID1B HRNR GLI3 PITX1 TNRC6A	6.79e-04	1429	37	7	35140242
Pubmed	Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.	HSPG2 HAPLN1	7.16e-04	37	37	2	32201365
Pubmed	ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia.	USP5 HRNR TNRC6A	7.36e-04	166	37	3	35687106
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	USP5 HRNR TNRC6A	7.89e-04	170	37	3	23314748
Pubmed	Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling.	FOXE1 GLI3	8.37e-04	40	37	2	17199044
Pubmed	Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis.	CUBN LIPG	8.80e-04	41	37	2	19878569
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	PRR12 HRNR TNRC6A	9.92e-04	184	37	3	32908313
Pubmed	Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.	FOXE1 CSMD1	1.01e-03	44	37	2	20200978
Pubmed	Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1.	HSPG2 HRNR	1.01e-03	44	37	2	31273033
Pubmed	Knockout mice with pituitary malformations help identify human cases of hypopituitarism.	PSAT1 ARID1B	1.06e-03	45	37	2	38822427
GeneFamily	Keratins, type I	KRT25 KRT37	7.35e-04	28	26	2	608
GeneFamily	Forkhead boxes	FOXE1 FOXC2	1.73e-03	43	26	2	508
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-OMD+_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	HSPG2 HEG1 LTBP3 FOXC2	1.61e-05	179	38	4	8c9ed247e1c4d655b81ce2f24a9936a7cade718a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	CUBN CSMD1 FAT3 TNRC6A	1.68e-05	181	38	4	c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell	10x3'2.3-week_14-16-Mesenchymal_fibro-stroma-endosteal_fibroblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	CSMD1 KRT25 GLI3 HAPLN1	1.95e-05	188	38	4	0e2d1b21f0a7ee306e7dae16fc8c19d16a467883
ToppCell	343B-Endothelial_cells-Endothelial-B_(Artery)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	HSPG2 HEG1 CUBN LIPG	2.08e-05	191	38	4	1dfcff08e01e6a695953334342bcfde04ba005ad
ToppCell	343B-Endothelial_cells-Endothelial-B_(Artery)\|343B / Donor, Lineage, Cell class and subclass (all cells)	HSPG2 HEG1 CUBN LIPG	2.08e-05	191	38	4	27a532a35d9e8822014f581fd56c4ca62e39f8fe
ToppCell	(6)_Endothelial-B_(Artery)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	HSPG2 HEG1 CUBN LIPG	2.21e-05	194	38	4	0cf4e67d4024652794b5bfdd4a71a7d98900b4c8
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG-25\|World / Primary Cells by Cluster	PSAT1 HEG1 LIPG GLI3	2.34e-05	197	38	4	9d4ffa3680f92c91d0a081f9a8ec5ebfec6bdcf6
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG\|World / Primary Cells by Cluster	PSAT1 HEG1 LIPG GLI3	2.34e-05	197	38	4	61749ccafeb938c310cff1de5ff924a1c794325a
ToppCell	Non-neuronal-Dividing-Radial_Glia-vRG-20\|World / Primary Cells by Cluster	PSAT1 HEG1 LIPG GLI3	2.39e-05	198	38	4	bce0bc1e3f2257e0f42a1fa6e5b57cf71e4514ba
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteoblast_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	GLI3 FAT3 HAPLN1 FOXC2	2.39e-05	198	38	4	bc9c9f2c87282b5ef8514773e065d2a6b5dde338
ToppCell	metastatic_Brain-Endothelial_cells-Tumor_ECs\|metastatic_Brain / Location, Cell class and cell subclass	HSPG2 HEG1 CUBN HAPLN1	2.39e-05	198	38	4	5e274f29cc796dae7d64d6035e904816c25f9914
ToppCell	metastatic_Brain-Endothelial_cells\|metastatic_Brain / Location, Cell class and cell subclass	HSPG2 HEG1 CUBN HAPLN1	2.39e-05	198	38	4	97ef7946ef11ac93318c1dd46b548dc01e5a6aba
ToppCell	10x5'v1-week_17-19-Mesenchymal_osteo-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	KLK4 FAT3 HAPLN1 FOXC2	2.48e-05	200	38	4	3c898e81444b001835c3f1bbc68183078701b135
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	KLK4 GLI3 FAT3 HAPLN1	2.48e-05	200	38	4	780d47f8eff630020dfae32218de495a7e9dbad6
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo-stroma\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	KLK4 GLI3 FAT3 HAPLN1	2.48e-05	200	38	4	28dd127787a57276253548d1f030814b1af64481
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	LTBP3 KLK4 HAPLN1 FOXC2	2.48e-05	200	38	4	ad3fb8ef0be45032369d1325024787fbe1dfb8d6
ToppCell	10x5'v1-week_17-19-Mesenchymal_osteo\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	KLK4 FAT3 HAPLN1 FOXC2	2.48e-05	200	38	4	3eca8ffeb41b664fbdbbd70b375c5d953503ab29
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Radial_glial\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	PSAT1 LIPG GLI3 HAPLN1	2.48e-05	200	38	4	ed4a41cb6782541d8fc928aaa12cf03bc1c630a2
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Radial_glial-gliogenic/outer_RGCs_and_astrocytes\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	PSAT1 LIPG GLI3 HAPLN1	2.48e-05	200	38	4	792fef1f3e47ce5c131fedfad55075fc254aeead
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic-Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRR12 HAPLN1 FOXC2	1.57e-04	123	38	3	87401764a073c1808f214642a9c84299c78f7ec7
ToppCell	LPS-IL1RA+antiTNF-Unknown-Endothelial-Pericyte_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CMPK2 CUBN LIPG	2.25e-04	139	38	3	2fb51abb3ce88c21726c026d6365b2582e2e79f6
ToppCell	normal_Lung-Endothelial_cells-Tumor_ECs\|Endothelial_cells / Location, Cell class and cell subclass	HSPG2 PSAT1 ZNF516-DT	3.04e-04	154	38	3	afdc385397c7b13c9348eeef95f109f2363057ae
ToppCell	PND28-Immune-Immune_Myeloid-Granulocytic-Basophil\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CAMTA2 PIM1 FAT3	3.21e-04	157	38	3	8c42af7aa1f1b6f4fe2f8d00a8b4a800f121e804
ToppCell	PND28-Immune-Immune_Myeloid-Granulocytic\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CAMTA2 PIM1 FAT3	3.21e-04	157	38	3	ee1be3c756b72fceac6b4ccb416dd4bd031a2193
ToppCell	PND28-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CAMTA2 PIM1 FAT3	3.21e-04	157	38	3	008f938a338f43c3251dcac574f1b4f689926c71
ToppCell	facs-Aorta-Heart-24m-Myeloid\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UCK2 PIM1 PITX1	3.34e-04	159	38	3	443f6df4a88fa8755adcde4cc12575dff614ecb4
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 HEG1 KLK4	3.52e-04	162	38	3	5428c9fdb816f564395ebb4520448e5f3a42b025
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-Tuft-related-Tuft\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAMTA2 CSMD1 LIPG	3.52e-04	162	38	3	80619a93c57fe16daf91dc571874ef9ac888953d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 HEG1 PITX1	3.59e-04	163	38	3	73c03e29a6d7a6863c5e9aa5e8b963ef691f1ddb
ToppCell	normal_Lung-Fibroblasts-Myofibroblasts\|Fibroblasts / Location, Cell class and cell subclass	ZNF516-DT EGR4 LIPG	3.65e-04	164	38	3	9b4a6007abae992db871d9f6f731d5af724de30d
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 HEG1 GLI3	3.78e-04	166	38	3	9d4b44eb56ad38c26aed73444edf389abca6bdf6
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FAT3 PITX1 HAPLN1	3.78e-04	166	38	3	d1c61270c7b39bb365020eeafe298a8f88aa887e
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HSPG2 HEG1 LIPG	3.78e-04	166	38	3	f7926ee266dcbf10df375cd921f1db5a2fa604f8
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CSMD1 LIPG FAT3	3.92e-04	168	38	3	8072d0496b7b730c4601009eaa69ec5366d26d73
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CMPK2 HSPG2 HEG1	3.99e-04	169	38	3	c7fc3a8c44f07c557b60d469717b66e2f5863d38
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FOXE1 CSMD1 GLI3	4.06e-04	170	38	3	2d880223d01bde4bf777bd6f50b7d2768489075f
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HSPG2 LIPG FAT3	4.06e-04	170	38	3	5570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FOXE1 CSMD1 GLI3	4.06e-04	170	38	3	0cc20322cb3e3e7bbd4daad8785c99f80e355c16
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CMPK2 HSPG2 HEG1	4.06e-04	170	38	3	55fe16d98ea284d05fb899888e4569c685644c7b
ToppCell	Endothelial-A-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	HSPG2 HEG1 LIPG	4.20e-04	172	38	3	a3201773a25832e92dd113fad165f1ecd37f5e91
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-epithelial_cell_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 KRTAP7-1 LIPG	4.27e-04	173	38	3	a5172dee859bf6c2eed46c48bd64dfef0ff9f28f
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Lgr5-_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 KRTAP7-1 LIPG	4.27e-04	173	38	3	639b5b0b33ce5aa0bc26363c059717012ddc14c0
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 HEG1 KLK4	4.27e-04	173	38	3	3877cead288ce9509e6cccf57e55ec5e1bd7ce18
ToppCell	droplet-Kidney-nan-18m-Lymphocytic-CD45____plasma_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRELD2 UCK2 PIM1	4.27e-04	173	38	3	60e427f6c7d953cef5f692043670ff0b49cdce72
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HSPG2 HAPLN1 FOXC2	4.34e-04	174	38	3	6b5ff1cc5fe6705f7ea70b5a892dfbf91e32288d
ToppCell	droplet-Kidney-nan-18m-Lymphocytic-plasma_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRELD2 UCK2 PIM1	4.34e-04	174	38	3	c92eec5a14ca5269673582dd115ead8516e64c3e
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-Myeloid-CLC+_Mast_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CMPK2 DENND1B EGR4	4.34e-04	174	38	3	36080fa12497faa752ff07ae52cd3864053eafef
ToppCell	Monocytes-IFN-activated_Monocytes\|Monocytes / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	CMPK2 BAZ2A PIM1	4.49e-04	176	38	3	6a4b403ee3e4dc4f23fbd7a154011e41fd429a9e
ToppCell	wk_20-22-Endothelial-Blood_vessel_endothelial-OMD+_endo\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	HSPG2 LTBP3 FOXC2	4.49e-04	176	38	3	52af8f717dbd3b59eeb868b8b7b256a8f3e57d7a
ToppCell	droplet-Spleen-SPLEEN-1m-Lymphocytic-plasma_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRELD2 LTBP3 CUBN	4.64e-04	178	38	3	b902059c3f861108fc64cbdc05e6f44378f5be2c
ToppCell	10x3'2.3-week_12-13-Mesenchymal_osteo-stroma-early_osteoblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	KLK4 FAT3 FOXC2	4.64e-04	178	38	3	e32f5ed7a492edfa7073416008b1fcfae6b854ad
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HSPG2 CSMD1 LIPG	4.72e-04	179	38	3	d2db9e70b780643f1e004c41a70464d0abe26088
ToppCell	Control-Myeloid-DC1\|Control / Condition, Lineage and Cell class	HSPG2 UCK2 DENND1B	4.87e-04	181	38	3	5a2a1f017ad23baed9972c68b4a46f4c618ef21a
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSPG2 PSAT1 CSMD1	4.95e-04	182	38	3	a1c0e4090a9e7aa4941a40c817d178de144888b6
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CMPK2 UCK2 DENND1B	5.03e-04	183	38	3	d1bf3abf42eb9d7facf775becf1338d1faadd647
ToppCell	10x3'2.3-week_17-19-Mesenchymal_osteo-stroma-early_osteoblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	KLK4 FAT3 HAPLN1	5.03e-04	183	38	3	27a57cd8ea924420e182f3d72f5b29b00dea8fa0
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CMPK2 UCK2 DENND1B	5.03e-04	183	38	3	bd78e5c2670e67b4363078e3ca5a5b7081d24b7e
ToppCell	metastatic_Brain-Endothelial_cells-Stalk-like_ECs\|metastatic_Brain / Location, Cell class and cell subclass	HSPG2 HEG1 CUBN	5.19e-04	185	38	3	ad52970e88e8947ef256095bd4b40229b912d58a
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HEG1 PICK1 FOXC2	5.19e-04	185	38	3	87151ab95530e70d61328b336518df58db584acb
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HSPG2 HEG1 CSMD1	5.19e-04	185	38	3	a7ae76058b2082020cadec49d63b9f4e24d21734
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 HEG1 PITX1	5.36e-04	187	38	3	a555a4af7946dec14a6b176ace4a4c2ecfd7f59e
ToppCell	Endothelial-A-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	HSPG2 HEG1 FOXC2	5.36e-04	187	38	3	febe0b99a6a815ce687160a0e7af55228b1d5beb
ToppCell	10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-muscle_stem_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	HSPG2 FAT3 FOXC2	5.44e-04	188	38	3	de6f4889e0c5f39fbbaefd85526f645c6afa09d5
ToppCell	Endothelial-Endothelial-E\|Endothelial / shred on cell class and cell subclass (v4)	HSPG2 HEG1 LTBP3	5.44e-04	188	38	3	2777eb7689b271c199021fe7d9db88ccebff14de
ToppCell	COPD-Epithelial-Mesothelial\|Epithelial / Disease state, Lineage and Cell class	UCK2 HEG1 PIM1	5.44e-04	188	38	3	159d63ecc3653a7449fc6acefd6ef0464845260e
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HSPG2 HEG1 CSMD1	5.52e-04	189	38	3	b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCell	Endothelial-endothelial_cell_of_artery\|World / Lineage, Cell type, age group and donor	HSPG2 HEG1 CSMD1	5.52e-04	189	38	3	fdd89c71113ac99b7c800c6def8888e512ff1128
ToppCell	COVID-19-Heart-EC_(POSTN)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	HSPG2 HEG1 CSMD1	5.52e-04	189	38	3	7346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HSPG2 HEG1 CSMD1	5.52e-04	189	38	3	c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-oRG/Astrocyte-7\|World / Primary Cells by Cluster	PSAT1 LIPG HAPLN1	5.61e-04	190	38	3	8f1c490dd8e5f80382f5294fd1aa8cba4c3c647f
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HSPG2 HEG1 CSMD1	5.61e-04	190	38	3	f6c38d197fd9d69a4f97cb2e72cd4747984c1a86
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-oRG/Astrocyte\|World / Primary Cells by Cluster	PSAT1 LIPG HAPLN1	5.61e-04	190	38	3	7dbfd543398c63cbe1e68b54bcb5e2291f521935
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HSPG2 HEG1 CUBN	5.61e-04	190	38	3	06bfb62b94b0faf467ef93d5bc5d08924c770098
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Artery\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HSPG2 HEG1 CSMD1	5.61e-04	190	38	3	aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-AEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	HSPG2 HEG1 CSMD1	5.69e-04	191	38	3	50601ef0a5a8f2c2120922989e08e85bf2d9b4ab
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Artery\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HSPG2 HEG1 CSMD1	5.69e-04	191	38	3	4b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 HEG1 HAPLN1	5.78e-04	192	38	3	25cb6cc6cbf8dc20139d938adfc02ed7a8c3dfb6
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	TNKS ARID1B TNRC6A	5.78e-04	192	38	3	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-Early_cap\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	HSPG2 LIPG HAPLN1	5.78e-04	192	38	3	4986ef70a665fdfa1df86f7f8a15117487eae159
ToppCell	Control-Endothelial-VE_Arterial\|Endothelial / Disease state, Lineage and Cell class	HSPG2 HEG1 CSMD1	5.78e-04	192	38	3	7e89b9125e8b85f6be85eeccef5c8644647ab0e1
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LTBP3 CSMD1 LIPG	5.78e-04	192	38	3	dc4b4e16e6eb212e45fb70695afd1c7e91027407
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	ARID1B CUBN TNRC6A	5.78e-04	192	38	3	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HSPG2 HEG1 LIPG	5.87e-04	193	38	3	c0f0052c24b7fe9e21d2bc6c38047a8e755f87b6
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LTBP3 CUBN CSMD1	5.87e-04	193	38	3	2b80991e7ba7640f7ab2139d30e4c54d8e533862
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-myofibroblast_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LTBP3 CUBN CSMD1	5.87e-04	193	38	3	90cfc34c2d0d7c70f071703d35db1d6037961481
ToppCell	3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HSPG2 HEG1 LIPG	5.87e-04	193	38	3	682ce63b73a7d02eef240673db67058d7507f744
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	TNKS ARID1B TNRC6A	5.87e-04	193	38	3	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	droplet-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 PIM1 PITX1	5.87e-04	193	38	3	2d891c00b8f0aace17d4c300b63e2341dcffa199
ToppCell	10x5'v1-week_17-19-Mesenchymal_osteo-stroma-early_osteoblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	KLK4 GLI3 FOXC2	5.87e-04	193	38	3	5e46a9f65e85aca78f825fdef88a95b97eec8743
ToppCell	Non-neuronal-Non-dividing\|World / Primary Cells by Cluster	PSAT1 LIPG GLI3	5.96e-04	194	38	3	0add09d97192b34bd506209ab5f1a77182f498fc
ToppCell	facs-Kidney-nan-3m-Endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMPK2 HSPG2 HEG1	5.96e-04	194	38	3	5fa2dfca32cca4abfda0af90b83f2b2a826f9b6e
ToppCell	facs-Kidney-nan-3m-Endothelial-fenestrated_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMPK2 HSPG2 HEG1	5.96e-04	194	38	3	04df35246287815bdd28adaf885bdb98cf49524e
ToppCell	distal-3-Hematologic-Plasma\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CRELD2 PSAT1 PIM1	5.96e-04	194	38	3	d6e2e17732ad75604525fd65b2a3171e86cd01c7
ToppCell	Non-neuronal-Non-dividing-Radial_Glia\|World / Primary Cells by Cluster	PSAT1 LIPG GLI3	5.96e-04	194	38	3	1445b7611c2b1ab9b320f330d17d70117892cc28
ToppCell	facs-Kidney-nan-3m-Endothelial-Pecam____fenestrated_capillary_endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMPK2 HSPG2 HEG1	5.96e-04	194	38	3	90928d6c96c6304ae35dcc0275f7889de93da100
ToppCell	343B-Endothelial_cells-Endothelial-B_(Artery)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	HSPG2 CUBN LIPG	5.96e-04	194	38	3	582db7f7fa9aa08027ae18ed607945b5d1dc908a
ToppCell	10x3'2.3-week_17-19-Mesenchymal_fibro-stroma-endosteal_fibroblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	GLI3 PITX1 HAPLN1	5.96e-04	194	38	3	69362e13158033de44f90f3773db6c0f27de8cb3
ToppCell	343B-Endothelial_cells-Endothelial-B_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	HSPG2 CUBN LIPG	5.96e-04	194	38	3	bda89111386398a072b70e8153b2a762298a047a
ToppCell	3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HSPG2 HEG1 LIPG	6.05e-04	195	38	3	53b83e16b350100b1d5791a9c42bd98e37cbc0af
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-Plasma_cell-B_c06-MKI67\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CRELD2 UCK2 PSAT1	6.05e-04	195	38	3	533818e89d809f01fbb5c4b57932b76aa5c8f30e
Disease	testicular carcinoma	UCK2 LIPG PITX1	1.88e-05	40	38	3	EFO_0005088
Disease	Craniofacial Abnormalities	HSPG2 LTBP3 HAPLN1 FOXC2	4.82e-05	156	38	4	C0376634
Disease	cortical thickness	HSPG2 ARID1B DENND1B GLI3 FAT3 PICK1 TNRC6A FOXC2	7.13e-05	1113	38	8	EFO_0004840
Disease	Amphetamine-Related Disorders	CUBN CSMD1 PICK1	1.25e-04	75	38	3	C0236733
Disease	Amphetamine Abuse	CUBN CSMD1 PICK1	1.25e-04	75	38	3	C0236807
Disease	Amphetamine Addiction	CUBN CSMD1 PICK1	1.25e-04	75	38	3	C0236804
Disease	physical activity	PSAT1 CSMD1 LIPG	2.00e-04	88	38	3	EFO_0003940
Disease	Congenital hernia of foramen of Morgagni	PIM1 FOXC2	2.72e-04	19	38	2	C0265699
Disease	Congenital hernia of foramen of Bochdalek	PIM1 FOXC2	2.72e-04	19	38	2	C0265700
Disease	Congenital diaphragmatic hernia	PIM1 FOXC2	3.34e-04	21	38	2	C0235833
Disease	emphysema	CSMD1 GLI3	9.35e-04	35	38	2	EFO_0000464
Disease	cognitive function measurement, self reported educational attainment	PRR12 PEF1 ARID1B TNRC6A	1.10e-03	355	38	4	EFO_0004784, EFO_0008354

Protein segments in the cluster

Peptide	Gene	Start	Entry
CNAPCGGQYTGSEGV	CSMD1	1621	Q96PZ7
FSGGQYPLNGILGGS	BAZ2A	116	Q9UIF9
LNSPQRGQTYGGGQG	CAMTA2	381	O94983
AGYGVLSSPRQQGGG	ARID1B	446	Q8NFD5
GYVGNPSVQGGQCLP	HSPG2	1656	P98160
DSGGPLICNGYLQGL	KLK4	206	Q9Y5K2
GGYQTLGENSNPYGG	GLI3	1211	P10071
PGNIGICGAYGKNTL	KRT37	86	O76014
GRGQCGSGSGQSPNY	HRNR	191	Q86YZ3
GNTGGGNPCAGFTVN	KRT25	56	Q7Z3Z0
IYPNGGDFQPGCGLN	LIPG	241	Q9Y5X9
PCAQGLEAGAAGGYQ	FOXC2	316	Q99958
VGAPGNCGSQGDYQA	EGR4	316	Q05215
GLGGLNCGNPYQLIT	HEG1	1236	Q9ULI3
LNQPYCGYAVGGSGV	NLRX1	326	Q86UT6
SSYGAQQPGLYGQGG	PEF1	96	Q9UBV8
GYTGNGYGPNGCVQL	CUBN	381	O60494
YSIAQCGGRVPGQSG	CUBN	2331	O60494
SFRQTLGPQQGCGGY	CUBN	3146	O60494
LGPQQGCGGYLTGSN	CUBN	3151	O60494
LCYCPGGQAGGAQQG	CMPK2	116	Q5EBM0
QHGGSCTGLPSGGYQ	FAT3	4031	Q8TDW7
GPGRGICMNTGGSYN	LTBP3	626	Q9NS15
GPSSYNQGQESGAGC	KPRP	531	Q5T749
FGGSNINNLGGCYGG	KRTAP7-1	56	Q8IUC3
GTYGPDCLACQGGSQ	CRELD2	131	Q6UXH1
ITSGGFCGGNPRSYQ	DENND1B	406	Q6P3S1
CGGQNTVPGVRNYGF	HAPLN1	226	P10915
SQYQVGPLLGSGGFG	PIM1	36	P11309
GYGGLQGPASGLNAC	PITX1	296	P78337
GQFGALGACYNPGGQ	FOXE1	331	O00358
LGACYNPGGQLGGAS	FOXE1	336	O00358
AGLGGCPYAQGASGN	HMGCL	261	P35914
QGGGCGQFSAVPLNL	PSAT1	76	Q9Y617
GQPQGLLGPQAYGQG	PRR12	446	Q9ULL5
LLGPQAYGQGFGGGQ	PRR12	451	Q9ULL5
LIGTNINGNPYGLGS	C12orf29	196	Q8N999
SNQYVYGIGGGTGCP	TNKS	1221	O95271
GGPSKRQTNGCLNGY	UCK2	231	Q9BZX2
SNQRCNPGGYLSGGV	ZNF516-DT	56	Q6ZTR6
NLIGISIGGGAQYCP	PICK1	31	Q9NRD5
GIFGGQGNSLLCSYG	WDR87	476	Q6ZQQ6
GSNYSGDKCSGPNGQ	TNRC6A	526	Q8NDV7
FGPGYTGIRNLGNSC	USP5	321	P45974