Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	axon hillock	MAP2 TPX2	1.54e-04	9	44	2	GO:0043203
GeneOntologyCellularComponent	eukaryotic translation initiation factor 3 complex, eIF3m	EIF3C EIF3CL	1.54e-04	9	44	2	GO:0071541
GeneOntologyCellularComponent	eukaryotic translation initiation factor 3 complex	EIF3C EIF3CL	5.10e-04	16	44	2	GO:0005852
GeneOntologyCellularComponent	endoplasmic reticulum lumen	RCN2 HSP90B1 SPP1 SDC2 PROC	6.41e-04	332	44	5	GO:0005788
GeneOntologyCellularComponent	eukaryotic 48S preinitiation complex	EIF3C EIF3CL	6.48e-04	18	44	2	GO:0033290
GeneOntologyCellularComponent	eukaryotic 43S preinitiation complex	EIF3C EIF3CL	7.24e-04	19	44	2	GO:0016282
GeneOntologyCellularComponent	translation preinitiation complex	EIF3C EIF3CL	8.03e-04	20	44	2	GO:0070993
HumanPheno	Absent earlobe	ESCO2 CENPE RBBP8	2.81e-05	20	16	3	HP:0000387
Domain	EIF3C_N_dom	EIF3C EIF3CL	4.70e-06	2	41	2	IPR008905
Domain	eIF-3c_N	EIF3C EIF3CL	4.70e-06	2	41	2	PF05470
Domain	EIF3C	EIF3C EIF3CL	4.70e-06	2	41	2	IPR027516
Domain	UmuC	ESCO2 REV1	7.01e-05	6	41	2	IPR001126
Domain	PINT	EIF3C EIF3CL	5.53e-04	16	41	2	SM00088
Domain	PCI	EIF3C EIF3CL	6.26e-04	17	41	2	PF01399
Domain	PCI_dom	EIF3C EIF3CL	6.26e-04	17	41	2	IPR000717
Domain	Nucleotide-bd_a/b_plait	SAFB RBM48 DDX50 RBM27	2.41e-03	258	41	4	IPR012677
Domain	ER_TARGET	RCN2 HSP90B1	4.77e-03	47	41	2	PS00014
Pathway	REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS	HSP90B1 SPP1 SDC2 PROC	1.01e-04	120	29	4	MM14982
Pathway	REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS	HSP90B1 SPP1 SDC2 PROC	1.14e-04	124	29	4	M27285
Pathway	WP_OSTEOPONTIN_SIGNALING	SPP1 ITGB3	3.14e-04	13	29	2	M39603
Pathway	REACTOME_SYNDECAN_INTERACTIONS	ITGB3 SDC2	3.66e-04	14	29	2	MM14923
Pathway	WP_OSTEOCLAST_SIGNALING	SPP1 ITGB3	3.66e-04	14	29	2	MM15987
Pathway	WP_OSTEOCLAST_SIGNALING	SPP1 ITGB3	4.82e-04	16	29	2	M39694
Pathway	KEGG_ECM_RECEPTOR_INTERACTION	SPP1 ITGB3 SDC2	6.67e-04	84	29	3	M7098
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	ZNF740 XRN2 SAFB EIF3C RBM27 NIPBL PHF3 BCLAF1 EIF3CL TPX2	7.43e-10	503	45	10	16964243
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	XRN2 SAFB EIF3C USP42 RBBP8 NIPBL PHF3 BCLAF1 TBC1D9 EIF3CL TPX2	3.15e-09	774	45	11	15302935
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	EVPL HSP90B1 XRN2 SAFB EIF3C DDX50 RBM27 PHF3 BCLAF1 RSRC1 TPX2	7.99e-09	847	45	11	35850772
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ANKRD11 ZNF740 XRN2 SAFB DDX50 USP42 RBM27 NIPBL PHF3 BCLAF1 RSRC1 TPX2	6.17e-08	1294	45	12	30804502
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	RCN2 HSP90B1 XRN2 SAFB EIF3C DDX50 MAP2 USP42 RBM27 NIPBL BCLAF1	9.67e-08	1082	45	11	38697112
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	RCN2 ARHGDIA HSP90B1 PNPLA8 XRN2 SAFB EIF3C DDX50 NIPBL BCLAF1 PCLO EIF3CL	1.75e-07	1425	45	12	30948266
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	C1orf52 ARHGDIA HSP90B1 SAFB EIF3C DDX50 RBM27 NIPBL BCLAF1 TPX2	2.53e-07	934	45	10	33916271
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	RCN2 ZNF740 XRN2 SAFB EIF3C DDX50 SDC2	3.16e-07	349	45	7	25665578
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	HSP90B1 XRN2 SAFB EIF3C DDX50 USP42 RBM27 PHF3 BCLAF1 TPX2	4.27e-07	989	45	10	36424410
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	RCN2 EVPL HSP90B1 XRN2 SAFB DDX50 RBM27 PHF3 BCLAF1 EIF3CL TPX2	4.31e-07	1257	45	11	36526897
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	XRN2 SAFB RBM27 BCLAF1 TPX2	1.39e-06	148	45	5	32538781
Pubmed	The involvement of osteopontin and β3 integrin in implantation and endometrial receptivity in an early mouse pregnancy model.	SPP1 ITGB3	1.64e-06	2	45	2	23870190
Pubmed	[Expression of integrin beta3 and osteopontin in endometrium of patients with adenomyosis].	SPP1 ITGB3	1.64e-06	2	45	2	19573311
Pubmed	EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis.	EIF3C EIF3CL	1.64e-06	2	45	2	36157221
Pubmed	Beta(3) integrin expression increases breast carcinoma cell responsiveness to the malignancy-enhancing effects of osteopontin.	SPP1 ITGB3	1.64e-06	2	45	2	14517343
Pubmed	Association between the hypomethylation of osteopontin and integrin β3 promoters and vascular smooth muscle cell phenotype switching in great saphenous varicose veins.	SPP1 ITGB3	1.64e-06	2	45	2	25329616
Pubmed	Expression of integrin β3 and osteopontin in the eutopic endometrium of adenomyosis during the implantation window.	SPP1 ITGB3	1.64e-06	2	45	2	24021319
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	EVPL HSP90B1 SAFB DDX50 RBBP8 NIPBL BCLAF1 TPX2	1.71e-06	652	45	8	31180492
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	ANKRD11 RCN2 AUTS2 C1orf52 HSP90B1 XRN2 BCLAF1 SDC2 TBC1D9	2.34e-06	922	45	9	27609421
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	HSP90B1 XRN2 SAFB EIF3C RBM27 RSRC1 EIF3CL REV1	2.92e-06	701	45	8	30196744
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	HSP90B1 XRN2 SAFB EIF3C DDX50 BCLAF1 SDC2 EIF3CL TPX2	2.96e-06	949	45	9	36574265
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	ANKRD11 XRN2 SAFB DDX50 RBM27 NIPBL PHF3 BCLAF1 TPX2	3.09e-06	954	45	9	36373674
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	RCN2 ARHGDIA HSP90B1 XRN2 SAFB EIF3C DDX50 BCLAF1	3.34e-06	714	45	8	28302793
Pubmed	RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.	ESCO2 HSP90B1 SAFB RBM27 PHF3	3.93e-06	183	45	5	28186131
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	HSP90B1 XRN2 SAFB EIF3C DDX50 RBM27 BCLAF1 RSRC1	3.98e-06	731	45	8	29298432
Pubmed	Abrogation of the interaction between osteopontin and alphavbeta3 integrin reduces tumor growth of human lung cancer cells in mice.	SPP1 ITGB3	4.91e-06	3	45	2	17482311
Pubmed	Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin α(V)β(3) engagement and PI3K/pAkt/NFκB signaling.	SPP1 ITGB3	4.91e-06	3	45	2	21953216
Pubmed	The 10q26 Risk Haplotype of Age-Related Macular Degeneration Aggravates Subretinal Inflammation by Impairing Monocyte Elimination.	HTRA1 SPP1	4.91e-06	3	45	2	32814029
Pubmed	Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation.	SPP1 ITGB3	4.91e-06	3	45	2	12377945
Pubmed	Molecular dynamics and docking simulation of a natural variant of Activated Protein C with impaired protease activity: implications for integrin-mediated antiseptic function.	ITGB3 PROC	4.91e-06	3	45	2	24251463
Pubmed	Integrin β3 and CD44 levels determine the effects of the OPN-a splicing variant on lung cancer cell growth.	SPP1 ITGB3	4.91e-06	3	45	2	27487131
Pubmed	Osteopontin and alphavbeta3 integrin expression in the endometrium of infertile and fertile women.	SPP1 ITGB3	4.91e-06	3	45	2	18549690
Pubmed	Infertile women with isolated polycystic ovaries are deficient in endometrial expression of osteopontin but not alphavbeta3 integrin during the implantation window.	SPP1 ITGB3	4.91e-06	3	45	2	18353318
Pubmed	The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro.	SPP1 ITGB3	4.91e-06	3	45	2	7532190
Pubmed	Osteopontin and alphavbeta3 integrin as markers of endometrial receptivity: the effect of different hormone therapies.	SPP1 ITGB3	4.91e-06	3	45	2	20638909
Pubmed	Mechanistic Insight on the Interaction between OPN and Integrin ανβ3 in Osteoarthritis.	SPP1 ITGB3	4.91e-06	3	45	2	33134374
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	EVPL HSP90B1 SAFB ITGB3 NIPBL BCLAF1	6.84e-06	360	45	6	33111431
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	SAFB DDX50 CENPE PHF3 BCLAF1 REV1	6.95e-06	361	45	6	26167880
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	ZNF740 XRN2 EIF3C DDX50 PHF3 BCLAF1 TPX2	9.37e-06	583	45	7	29844126
Pubmed	Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis.	SPP1 ITGB3	9.81e-06	4	45	2	19017937
Pubmed	Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.	EIF3C EIF3CL	9.81e-06	4	45	2	10504338
Pubmed	Substrate specificity of alpha(v)beta(3) integrin-mediated cell migration and phosphatidylinositol 3-kinase/AKT pathway activation.	SPP1 ITGB3	9.81e-06	4	45	2	10835423
Pubmed	Hypoxia-driven paracrine osteopontin/integrin αvβ3 signaling promotes pancreatic cancer cell epithelial-mesenchymal transition and cancer stem cell-like properties by modulating forkhead box protein M1.	SPP1 ITGB3	9.81e-06	4	45	2	30367545
Pubmed	Overexpression of osteopontin, αvβ3 and Pim-1 associated with prognostically important clinicopathologic variables in non-small cell lung cancer.	SPP1 ITGB3	9.81e-06	4	45	2	23119061
Pubmed	MFG-E8 attenuates intestinal inflammation in murine experimental colitis by modulating osteopontin-dependent alphavbeta3 integrin signaling.	SPP1 ITGB3	9.81e-06	4	45	2	19454719
Pubmed	Osteopontin promotes a cancer stem cell-like phenotype in hepatocellular carcinoma cells via an integrin-NF-κB-HIF-1α pathway.	SPP1 ITGB3	9.81e-06	4	45	2	25749383
Pubmed	Milk osteopontin promotes intestinal development by up-regulating the expression of integrin αvβ3 and CD44.	SPP1 ITGB3	9.81e-06	4	45	2	37219531
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	XRN2 DDX50 CENPE BCLAF1 TPX2	1.30e-05	234	45	5	36243803
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	HSP90B1 XRN2 EIF3C DDX50 NIPBL TPX2	1.43e-05	410	45	6	26949251
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	RCN2 C1orf52 EIF3C CENPE NIPBL BCLAF1 RSRC1 EIF3CL TPX2	1.44e-05	1155	45	9	20360068
Pubmed	Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.	ESCO2 CENPE TOPAZ1 BCLAF1	1.57e-05	116	45	4	21282530
Pubmed	Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9.	SPP1 ITGB3	1.63e-05	5	45	2	27264390
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	XRN2 SAFB DDX50 PHF3 SDC2	1.82e-05	251	45	5	28077445
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	RCN2 XRN2 SAFB EIF3C DDX50 RBM27 TPX2	1.95e-05	653	45	7	33742100
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	XRN2 DDX50 RBM27 PHF3 BCLAF1 TPX2	2.13e-05	440	45	6	34244565
Pubmed	Ethanol increases fetal human neurosphere size and alters adhesion molecule gene expression.	SPP1 ITGB3	2.45e-05	6	45	2	18162078
Pubmed	Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology.	MAP2 SDC2	2.45e-05	6	45	2	21555464
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	HSP90B1 XRN2 SAFB RBM27 BCLAF1	2.76e-05	274	45	5	34244482
Pubmed	SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.	RCN2 ARHGDIA HSP90B1 SAFB EIF3C TPX2	2.83e-05	463	45	6	34901782
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	ESCO2 C1orf52 ARHGDIA SAFB PHF3 RSRC1	3.15e-05	472	45	6	38943005
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	DDX50 RBM27 PHF3 BCLAF1 TPX2	3.22e-05	283	45	5	30585729
Pubmed	Osteopontin increases migration and MMP-9 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells.	SPP1 ITGB3	3.42e-05	7	45	2	19475568
Pubmed	CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins.	SAFB BCLAF1	3.42e-05	7	45	2	12890497
Pubmed	The in vivo brain interactome of the amyloid precursor protein.	RCN2 HSP90B1 PLPP1	3.80e-05	50	45	3	17934213
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	HSP90B1 XRN2 SAFB DDX50 USP42 RBM27 NIPBL RSRC1 EIF3CL	4.05e-05	1318	45	9	30463901
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	ARHGDIA XRN2 SAFB RBM27 NIPBL PHF3 BCLAF1 TPX2	4.20e-05	1014	45	8	32416067
Pubmed	WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation.	ANKRD11 USP42 ITGB3	4.28e-05	52	45	3	30655611
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	ARHGDIA HSP90B1 XRN2 SAFB EIF3C DDX50 NIPBL BCLAF1	4.50e-05	1024	45	8	24711643
Pubmed	Distinct structural requirements for binding of the integrins alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 to osteopontin.	SPP1 ITGB3	4.56e-05	8	45	2	16005200
Pubmed	The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.	EIF3C EIF3CL	5.86e-05	9	45	2	21292980
Pubmed	The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control.	EIF3C EIF3CL	5.86e-05	9	45	2	24003236
Pubmed	Global phosphoproteome of HT-29 human colon adenocarcinoma cells.	EIF3C BCLAF1 EIF3CL	6.25e-05	59	45	3	16083285
Pubmed	A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.	RCN2 ARHGDIA HSP90B1 SAFB EIF3C RBM27 BCLAF1	6.30e-05	786	45	7	29128334
Pubmed	mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.	EIF3C EIF3CL	7.32e-05	10	45	2	16286006
Pubmed	Conservation and diversity of eukaryotic translation initiation factor eIF3.	EIF3C EIF3CL	7.32e-05	10	45	2	8995409
Pubmed	The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence.	ITGB3 SDC2	7.32e-05	10	45	2	7690138
Pubmed	Evolutionary history and genome organization of DUF1220 protein domains.	NBPF12 NBPF1	7.32e-05	10	45	2	22973535
Pubmed	Human transcription factor protein interaction networks.	RCN2 AUTS2 XRN2 EIF3C DDX50 RBM27 NIPBL RSRC1 TPX2	7.57e-05	1429	45	9	35140242
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	C1orf52 ARHGDIA XRN2 SAFB RBM27 NIPBL BCLAF1 TPX2	7.58e-05	1103	45	8	34189442
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	ARHGDIA HSP90B1 SAFB HTRA1 EIF3C MAP2 BCLAF1 PCLO EIF3CL	7.65e-05	1431	45	9	37142655
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	HSP90B1 SAFB DDX50 CCDC57 RBBP8 NIPBL BCLAF1 PCLO RETREG1	8.11e-05	1442	45	9	35575683
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	XRN2 EIF3C DDX50 RBM27	9.14e-05	182	45	4	32239614
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	HSP90B1 SAFB EIF3C KCNQ5 MAP2 BCLAF1 PCLO EIF3CL	9.48e-05	1139	45	8	36417873
Pubmed	DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis.	ARHGDIA EIF3C EIF3CL	1.04e-04	70	45	3	34255829
Pubmed	Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3.	EIF3C EIF3CL	1.07e-04	12	45	2	14519125
Pubmed	Reconstitution reveals the functional core of mammalian eIF3.	EIF3C EIF3CL	1.07e-04	12	45	2	17581632
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ANKRD11 RCN2 EIF3C DDX50 RBM27 NIPBL PHF3 RSRC1 TPX2	1.08e-04	1497	45	9	31527615
Pubmed	Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F.	EIF3C BCLAF1 EIF3CL	1.28e-04	75	45	3	31527668
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	AUTS2 ZNF740 HSP90B1 SAFB USP42 RBM27 PHF3 BCLAF1	1.38e-04	1203	45	8	29180619
Pubmed	Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.	PHF3 BCLAF1	1.47e-04	14	45	2	28263302
Pubmed	Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.	EIF3C EIF3CL	1.47e-04	14	45	2	18599441
Pubmed	Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.	RCN2 HSP90B1 XRN2 SAFB DDX50 BCLAF1	1.49e-04	626	45	6	33644029
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	CENPE NIPBL BCLAF1 TPX2	1.59e-04	210	45	4	16565220
Pubmed	Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry.	EIF3C EIF3CL	1.70e-04	15	45	2	17322308
Pubmed	The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.	NIPBL PHF3 TPX2	1.92e-04	86	45	3	37253089
Pubmed	GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.	XRN2 EIF3C DDX50 BCLAF1	1.93e-04	221	45	4	29991511
Pubmed	Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.	XRN2 EIF3C DDX50 BCLAF1	1.99e-04	223	45	4	20020773
Pubmed	Rho-associated protein kinase-dependent moesin phosphorylation is required for PD-L1 stabilization in breast cancer.	ARHGDIA HSP90B1 DDX50 TPX2	2.03e-04	224	45	4	32941674
Pubmed	Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.	C1orf52 ARHGDIA SAFB NIPBL PCLO	2.17e-04	425	45	5	24999758
Pubmed	Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c.	EIF3C EIF3CL	2.20e-04	17	45	2	34752747
Interaction	DOT1L interactions	EVPL HSP90B1 XRN2 SAFB EIF3C DDX50 RBM27 PHF3 RSRC1 TPX2	8.95e-06	807	45	10	int:DOT1L
Interaction	CSNK2A1 interactions	ANKRD11 AUTS2 HSP90B1 XRN2 SAFB EIF3C SPP1 BCLAF1 RSRC1 EIF3CL	3.86e-05	956	45	10	int:CSNK2A1
Interaction	NAA40 interactions	C1orf52 ARHGDIA HSP90B1 SAFB EIF3C DDX50 RBM27 NIPBL BCLAF1 TPX2	4.68e-05	978	45	10	int:NAA40
Interaction	CIT interactions	RCN2 HSP90B1 PNPLA8 XRN2 SAFB DDX50 RBM27 NIPBL BCLAF1 PCLO EIF3CL TPX2	5.68e-05	1450	45	12	int:CIT
Interaction	DDX23 interactions	ANKRD11 XRN2 SAFB DDX50 PHF3 BCLAF1 RSRC1	8.63e-05	480	45	7	int:DDX23
Interaction	BMI1 interactions	EVPL ZNF740 XRN2 EIF3C PHF3 BCLAF1 RSRC1 EIF3CL	9.26e-05	659	45	8	int:BMI1
Interaction	MECP2 interactions	RCN2 HSP90B1 XRN2 SAFB EIF3C DDX50 MAP2 USP42 RBM27 NIPBL BCLAF1	9.33e-05	1287	45	11	int:MECP2
Interaction	CSNK2A3 interactions	AUTS2 EIF3C BCLAF1 EIF3CL	1.05e-04	110	45	4	int:CSNK2A3
Interaction	AIM2 interactions	RCN2 ZNF740 SAFB DDX50	1.05e-04	110	45	4	int:AIM2
Interaction	CLK1 interactions	SAFB CENPE PHF3 BCLAF1 REV1	1.24e-04	219	45	5	int:CLK1
Interaction	PYHIN1 interactions	RCN2 XRN2 SAFB DDX50 PHF3 SDC2	1.37e-04	358	45	6	int:PYHIN1
Interaction	CSNK2A2 interactions	AUTS2 HSP90B1 EIF3C SPP1 BCLAF1 SDC2 RSRC1 EIF3CL	1.67e-04	718	45	8	int:CSNK2A2
Interaction	TERF2IP interactions	ANKRD11 C1orf52 XRN2 RBM27 NIPBL PHF3 TPX2	2.05e-04	552	45	7	int:TERF2IP
Interaction	TNIP2 interactions	ANKRD11 RCN2 AUTS2 C1orf52 HSP90B1 XRN2 BCLAF1 SDC2 TBC1D9	2.15e-04	952	45	9	int:TNIP2
Interaction	CYCS interactions	ARHGDIA SAFB RBM27 PHF3 RSRC1	2.17e-04	247	45	5	int:CYCS
Interaction	UQCR11 interactions	ESCO2 PHF3 RSRC1	2.25e-04	53	45	3	int:UQCR11
Interaction	DHX40 interactions	ANKRD11 XRN2 SAFB RBM27 BCLAF1	2.26e-04	249	45	5	int:DHX40
Interaction	SAA1 interactions	SAFB PHF3 RSRC1	2.38e-04	54	45	3	int:SAA1
Interaction	STMN3 interactions	ANKRD11 TXLNB MAP2	2.52e-04	55	45	3	int:STMN3
Interaction	MYO10 interactions	ARHGDIA HSP90B1 ITGB3 BCLAF1	2.74e-04	141	45	4	int:MYO10
Interaction	EIF3C interactions	HSP90B1 EIF3C MAP2 PCLO EIF3CL	2.91e-04	263	45	5	int:EIF3C
Interaction	SMC5 interactions	ANKRD11 XRN2 SAFB DDX50 RBM27 NIPBL PHF3 BCLAF1 TPX2	3.10e-04	1000	45	9	int:SMC5
Interaction	SNIP1 interactions	XRN2 EIF3C DDX50 NIPBL BCLAF1 TPX2	3.12e-04	417	45	6	int:SNIP1
Interaction	C18orf54 interactions	ANKRD11 TXLNB	3.17e-04	12	45	2	int:C18orf54
Interaction	KLF16 interactions	RCN2 HSP90B1 XRN2 EIF3C NIPBL TPX2	3.45e-04	425	45	6	int:KLF16
Interaction	BTF3 interactions	RCN2 HSP90B1 XRN2 SAFB EIF3C TXLNB DDX50 BCLAF1	3.45e-04	799	45	8	int:BTF3
Interaction	RBM39 interactions	RCN2 ARHGDIA HSP90B1 XRN2 SAFB EIF3C DDX50 BCLAF1 RSRC1	4.19e-04	1042	45	9	int:RBM39
Interaction	CSNK2B interactions	ANKRD11 AUTS2 HTRA1 EIF3C BCLAF1 RSRC1 PROC	4.34e-04	625	45	7	int:CSNK2B
Interaction	RECQL interactions	ESCO2 HSP90B1 SAFB RBM27 PHF3	4.48e-04	289	45	5	int:RECQL
Cytoband	Ensembl 112 genes in cytogenetic band chr17q25	ARHGDIA EVPL CCDC57	3.41e-03	307	45	3	chr17q25
Cytoband	17q25.3	ARHGDIA CCDC57	4.46e-03	101	45	2	17q25.3
GeneFamily	Neuroblastoma breakpoint family	NBPF12 NBPF1	6.15e-04	23	29	2	662
GeneFamily	RNA binding motif containing	SAFB RBM48 RBM27	4.70e-03	213	29	3	725
Coexpression	HAMAI_APOPTOSIS_VIA_TRAIL_UP	RCN2 HSP90B1 CENPE RBM27 SPP1 RBBP8 NIPBL PHF3 BCLAF1 TBC1D9 RETREG1	1.04e-08	656	45	11	M18979
Coexpression	GSE13547_CTRL_VS_ANTI_IGM_STIM_BCELL_2H_UP	ESCO2 EIF3C CENPE RBBP8 TPX2	1.53e-05	183	45	5	M2993
Coexpression	GSE29617_CTRL_VS_DAY3_TIV_FLU_VACCINE_PBMC_2008_UP	ANKRD11 C1orf52 USP42 PHF3 BCLAF1	2.13e-05	196	45	5	M4928
Coexpression	MENON_FETAL_KIDNEY_4_PODOCYTES	ANKRD11 HSP90B1 HTRA1 SDC2 RETREG1	2.70e-05	206	45	5	M39254
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3	ANKRD11 SAFB EIF3C CENPE RBM27 RBBP8 NIPBL PHF3 BCLAF1 PCLO TPX2	8.00e-09	532	44	11	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500	ESCO2 AUTS2 KCNQ5 MAP2 USP42 CENPE RBM27 SPP1 RBBP8 NIPBL PHF3 BCLAF1 RSRC1 TPX2	7.97e-07	1459	44	14	facebase_RNAseq_e10.5_Emin_LatNas_2500
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3	ESCO2 AUTS2 USP42 CENPE RBM27 SPP1 RBBP8 NIPBL PHF3 BCLAF1 RSRC1 TPX2	6.32e-06	1257	44	12	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_2500_k-means-cluster#1	ANKRD11 EIF3C CENPE RBBP8 NIPBL BCLAF1 TPX2	4.63e-05	469	44	7	Facebase_RNAseq_e8.5_Floor Plate_2500_K1
CoexpressionAtlas	facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4	ESCO2 AUTS2 C1orf52 MAP2 CENPE NIPBL PHF3 BCLAF1 TBC1D9 TPX2 REV1	8.21e-05	1370	44	11	facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4
CoexpressionAtlas	alpha beta T cells, NKT.44+NK1.1-.Th, aGC CD1d tet CD3 CD44, Thymus, avg-3	ESCO2 KCNQ5 MAP2 CENPE ITGB3 TPX2	1.49e-04	392	44	6	GSM538335_500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_1000	ANKRD11 SAFB MAP2 CENPE RBM27 RBBP8 BCLAF1 PCLO TPX2	1.54e-04	983	44	9	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_1000
CoexpressionAtlas	alpha beta T cells, NKT.44-NK1.1-.Th, aGC CD1d tet CD3e, Thymus, avg-2	ESCO2 KCNQ5 MAP2 CENPE ITGB3 TPX2	1.61e-04	398	44	6	GSM538338_500
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_1000_k-means-cluster#1	ANKRD11 RBBP8 NIPBL PHF3 PCLO	1.91e-04	259	44	5	Facebase_RNAseq_e8.5_Floor Plate_1000_K1
ToppCell	droplet-Lung-3m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ESCO2 CENPE SPP1 TOPAZ1 TBC1D9 TPX2	3.18e-08	185	45	6	57c1eb50a4456d20953e48d5dc3b0ea3d0d81b6d
ToppCell	Control-Neu_4\|Control / 5 Neutrophil clusters in COVID-19 patients	C1orf52 HSP90B1 EIF3C DDX50 CENPE TPX2	4.48e-08	196	45	6	b8b7b54ca17a08fa775507bb22b1c7248ada8f40
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	ANKRD11 NIPBL PHF3 BCLAF1 KRCC1 PCLO	4.90e-08	199	45	6	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	Control-B_intermediate-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NBPF12 EIF3C PLPP1 NBPF1 EIF3CL	7.19e-07	167	45	5	948504367ecf58144d9dd74d2ec531358fc4b309
ToppCell	10x5'-Lung-Myeloid_Dendritic-Cycling_Dendritic\|Lung / Manually curated celltypes from each tissue	ESCO2 ZNF594 EIF3C CENPE TPX2	8.56e-07	173	45	5	62e0c18cfed9645e34a9d7029c94a8554f773714
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ESCO2 CCDC57 CENPE SPP1 TPX2	1.10e-06	182	45	5	21dcab170ffeef89faa9fee5008568cb6e15c694
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKRD11 XRN2 NIPBL PHF3 BCLAF1	1.16e-06	184	45	5	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ESCO2 HTRA1 CENPE SDC2 TPX2	1.29e-06	188	45	5	95d0a796d62ce6d121e2028c378faffc14b35275
ToppCell	P07-Mesenchymal-developing_mesenchymal_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KCNQ5 CENPE SDC2 TPX2 RETREG1	1.39e-06	191	45	5	ddbc5f97f2aef19be4ad93db4139876c939b848e
ToppCell	P07-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ESCO2 HTRA1 CENPE SDC2 TPX2	1.43e-06	192	45	5	5ef79faddb433c09ff36660d8bf7a3af5a67bf1d
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ESCO2 HTRA1 CENPE SDC2 TPX2	1.47e-06	193	45	5	a332dfdcc48c405020014e644aa4d14fda98cc86
ToppCell	droplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ESCO2 CENPE SPP1 TBC1D9 TPX2	1.54e-06	195	45	5	c1435e61e4f0cf457f26ae436936048932ceb0db
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ESCO2 HTRA1 CENPE SDC2 TPX2	1.66e-06	198	45	5	148f5fee19ea8dff7f2de4ca69c3b03e5221985d
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like_Prolif-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ESCO2 RCN2 MAP2 CENPE TPX2	1.66e-06	198	45	5	36897e17de2e22ee6b23920ee6e60931903f3e5c
ToppCell	(2)_B_cell-(24)_B_cell_cycling\|(2)_B_cell / shred on Cell_type and subtype	ESCO2 CENPE SPP1 SDC2 TPX2	1.70e-06	199	45	5	d5a9a8a71c4de8cbcef947943f60838731bc640b
ToppCell	(02)_MMP9/10+-(2)_GFP_FOXI1\|(02)_MMP9/10+ / shred by cell type by condition	ANKRD11 RBM27 NIPBL PHF3 BCLAF1	1.70e-06	199	45	5	18a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCell	Sigmoid-Dendritic_cell-cycling_DCs\|Dendritic_cell / Region, Cell class and subclass	ESCO2 ANKRD11 CENPE RBBP8 TPX2	1.75e-06	200	45	5	372fe9018481a4e9ac6ab3af43705a48238c4376
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Stem_cells\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	ESCO2 CENPE RBBP8 SDC2 TPX2	1.75e-06	200	45	5	31dd81df9aa754a1e69b905bf9b8ce73ff8175aa
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	ANKRD11 HSP90B1 NIPBL PHF3 BCLAF1	1.75e-06	200	45	5	7dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Stem_cells-Neuroepithelial_cell\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	ESCO2 CENPE RBBP8 SDC2 TPX2	1.75e-06	200	45	5	54174a485a82480726fa06efa6e050ddea77cb3c
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_E\|368C / Donor, Lineage, Cell class and subclass (all cells)	ZNF740 CENPE NIPBL PCLO	2.54e-05	169	45	4	0d96c0b4fd26fbc0bf44ff7bed2936eebcc55b74
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ESCO2 MAP2 CENPE TPX2	2.84e-05	174	45	4	41eb0a214a8b4015a26311f77061c8147144f0e7
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ESCO2 HTRA1 CENPE TPX2	2.84e-05	174	45	4	7b2f35add804981c7d588a996bdbca6ec11a1ca5
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ESCO2 MAP2 CENPE TPX2	2.91e-05	175	45	4	15c69dd5635c9251c535f1e22467712e9667ae92
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KCNQ5 CENPE SDC2 TPX2	2.91e-05	175	45	4	fa16c6ba08dc0cc22e8cf049db0577811d080df6
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSP90B1 PNPLA8 HTRA1 TXLNB	2.97e-05	176	45	4	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HSP90B1 CENPE SPP1 TBC1D9	3.04e-05	177	45	4	67cc3a6461db5e0678f96b18224aeb83ad34b0f4
ToppCell	368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ESCO2 CENPE RBBP8 TPX2	3.04e-05	177	45	4	844017225e9039d1bc621a9630a30c2e9a51b36d
ToppCell	368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ESCO2 CENPE RBBP8 TPX2	3.04e-05	177	45	4	26c25d10aa511b64cc7db43a8deea7b5d31bca96
ToppCell	droplet-Lung-nan-18m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CENPE SPP1 TBC1D9 TPX2	3.25e-05	180	45	4	43fd5c498a87bb078d101298b472656f3294686a
ToppCell	Lymphoid-Lymphoid-T_cells_(cycle)\|Lymphoid / shred on cell class and cell subclass (v4)	ESCO2 CENPE RBBP8 TPX2	3.32e-05	181	45	4	b6b41cd5d43543fe7a093033dae52a789199db0e
ToppCell	COVID-19_Mild-CD4+_T_activated\|COVID-19_Mild / Disease condition and Cell class	EIF3C NBPF1 EIF3CL RETREG1	3.39e-05	182	45	4	877b6e611626628e709568747512f2827ebb2795
ToppCell	droplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ESCO2 CENPE TBC1D9 TPX2	3.46e-05	183	45	4	e91f00b75d43ee6293fdd4a129b789cd95f8d11a
ToppCell	P28-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KCNQ5 SPP1 SDC2 RETREG1	3.54e-05	184	45	4	23c24ab5786af33d605bc445d06117b9da6c6331
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESCO2 CENPE SPP1 PCLO	3.54e-05	184	45	4	16aa8e88bdd51b1d132d5cf33c29963b384a8bae
ToppCell	Control-T_cells-Cycling_NK/T_cells\|Control / group, cell type (main and fine annotations)	ESCO2 KCNQ5 CENPE TPX2	3.61e-05	185	45	4	9766216b41ee62bbac4caa25cb98ec5627a24075
ToppCell	droplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ESCO2 CENPE SPP1 PCLO	3.61e-05	185	45	4	b4af9ae4c358b48357cb135b740266e1652d886a
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KCNQ5 SPP1 SDC2 RETREG1	3.61e-05	185	45	4	b1e84228c95be8ccf7c3c1afb66b71ffb93cf61e
ToppCell	Dividing_Macrophages-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	ESCO2 CENPE SPP1 TPX2	3.69e-05	186	45	4	0067eb78d4c7e32b9563550d9fcaf13445ee6a48
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KCNQ5 SPP1 SDC2 RETREG1	3.69e-05	186	45	4	db9b67066fc003c7995ec205d15176bf40c97add
ToppCell	10x5'-Liver-Lymphocytic_NK-Cycling_NK\|Liver / Manually curated celltypes from each tissue	ESCO2 CENPE RBBP8 TPX2	3.85e-05	188	45	4	5eb94e652a734c6f15c68a178e9d05f0febcf34c
ToppCell	367C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ESCO2 LRRC42 RBBP8 TPX2	3.85e-05	188	45	4	f5102e8d95506c25c675094b86162a6a50087b64
ToppCell	MS-mono3\|MS / Condition, Cell_class and T cell subcluster	HTRA1 SPP1 SDC2 PCLO	3.85e-05	188	45	4	a50a766c2f02e776c8e5c6e0833ec241c61831c4
ToppCell	P28-Mesenchymal-developing_mesenchymal_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KCNQ5 SPP1 SDC2 RETREG1	3.85e-05	188	45	4	e7681efb4d2de7f1d8a89552fff76a829376bf1b
ToppCell	MS-mono3-\|MS / Condition, Cell_class and T cell subcluster	HTRA1 SPP1 SDC2 PCLO	3.85e-05	188	45	4	e8c1c2941ca4919e0097a65b692b7af8018e8886
ToppCell	E15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ESCO2 CENPE SDC2 TPX2	3.93e-05	189	45	4	d049f33115610bda4489968759f754730698b9cd
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KCNQ5 MAP2 SDC2 RETREG1	4.01e-05	190	45	4	7e4d80a3a7f83b6a50f1d0fe82fb6c242c39d5b0
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-immature_NKT_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESCO2 CENPE RBBP8 TPX2	4.01e-05	190	45	4	b99271d139c8d01e20feb95d99f79c9b2756b4cb
ToppCell	Endothelial-D_(cycle)\|World / shred on cell class and cell subclass (v4)	ESCO2 PLPP1 CENPE TPX2	4.09e-05	191	45	4	49a4d8f181558e3be9527a8ff9a178f3bb01323c
ToppCell	P03-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ESCO2 HTRA1 CENPE TPX2	4.09e-05	191	45	4	b978afe76754cc56e1672abca27be289bb56375b
ToppCell	COVID-19-kidney-Proliferating_T_cell\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ESCO2 KCNQ5 CENPE TPX2	4.09e-05	191	45	4	bae388e0e9447d576e68465d73d8313ef6925ffa
ToppCell	Mild-T/NK_proliferative\|World / Disease group and Cell class	ESCO2 CENPE RBBP8 TPX2	4.09e-05	191	45	4	9dba5526fd5ea8065ad305feb2ee562335f887c6
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ESCO2 CENPE SDC2 TPX2	4.09e-05	191	45	4	f764cc21fef87ebad765011098f647ae1bdf6158
ToppCell	droplet-Spleen-SPLEEN-30m-Lymphocytic-immature_NKT_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESCO2 CENPE SDC2 TPX2	4.09e-05	191	45	4	c8b99bd3a30c81ee4deba9cbf0196920ab3ab550
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KCNQ5 MAP2 SDC2 RETREG1	4.18e-05	192	45	4	158cc5736f154da1cb3186ffbf186eae10483e48
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KCNQ5 MAP2 SDC2 RETREG1	4.18e-05	192	45	4	f4ff62ac9c53eafbe917706de9af8b2d4bded4d4
ToppCell	P07-Endothelial-proliferative_endothelial_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ESCO2 PLPP1 CENPE TPX2	4.26e-05	193	45	4	1e95ef29357969ee385b4717c0b5a497390ac260
ToppCell	wk_15-18-Hematologic_Lymphocytic-T_&_ILC-Cycling_T\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ESCO2 CENPE TPX2 RETREG1	4.26e-05	193	45	4	bec113472c40c0106a9427248cbcf54548797596
ToppCell	P07-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ESCO2 PLPP1 CENPE TPX2	4.26e-05	193	45	4	0f21fb8b35f89f4c1c8109d1a4d3d08a452f9edd
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ESCO2 MAP2 CENPE TPX2	4.35e-05	194	45	4	7a66bd7d4fc9c6db861cedd2487f241e406869d1
ToppCell	E15.5-Mesenchymal-developing_mesenchymal_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ESCO2 CENPE SDC2 TPX2	4.35e-05	194	45	4	d840c1949c328779426c9172e02da09e968f0567
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESCO2 SPP1 TBC1D9 TPX2	4.35e-05	194	45	4	effd38e51062b225ecabc7e1c50154e65495d559
ToppCell	COVID-19-T_cells-Cycling_NK/T_cells\|COVID-19 / group, cell type (main and fine annotations)	ESCO2 KCNQ5 CENPE TPX2	4.44e-05	195	45	4	764ed100c28d9bc93ee5ecabc5291c8f184d78da
ToppCell	(1)_T_cells-(1)_T_cells_Dividing\|(1)_T_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	ESCO2 CENPE RBBP8 TPX2	4.44e-05	195	45	4	cf00a0b4f341f0487d5b37810abe2952fdd3f6f2
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Proliferating-Cycling_Progenitors\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	ESCO2 HTRA1 CENPE TPX2	4.53e-05	196	45	4	5905f0e3061a6b98b7a33d64c782c3dda2cd51ef
ToppCell	Control-T/NK_proliferative\|Control / Disease condition and Cell class	ESCO2 CENPE RBBP8 TPX2	4.53e-05	196	45	4	7b7bc25aef49bfd64f79303a92d527bf8188f7a6
ToppCell	mild-Lymphocytic-Prol._cells\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	ESCO2 CENPE RBBP8 TPX2	4.53e-05	196	45	4	b1d9866d5dfaefdb8bedaf01a750d97987acb3d1
ToppCell	control-Lymphocytic-Prol._cells\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	ESCO2 CENPE RBBP8 TPX2	4.53e-05	196	45	4	886f7c865b086d6ebb4a1746865c30af6bbed345
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HTRA1 CENPE SDC2 TPX2	4.62e-05	197	45	4	29b0a5927f80455eef7b793feabef69fba1a3df1
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-B_lymphocytic-plasma_cell\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ESCO2 HSP90B1 CENPE TPX2	4.62e-05	197	45	4	6fe013f98c64b3c5a4e61002254717fb411f8e59
ToppCell	COVID-19_Severe-T/NK_proliferative\|COVID-19_Severe / Disease condition and Cell class	ESCO2 CENPE RBBP8 TPX2	4.62e-05	197	45	4	718a84e9a8248080f2d964e7c6a3ba183ece9592
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ESCO2 PLPP1 CENPE TPX2	4.62e-05	197	45	4	1c89d6836eed30c50c765f7dde9cc8ee15c363d2
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ESCO2 PLPP1 CENPE TPX2	4.62e-05	197	45	4	a41420d4b6d502c2f594c054c7efbb5d4eac83ff
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasmablast\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ESCO2 KCNQ5 CENPE TPX2	4.71e-05	198	45	4	cfbe0bae21b6cd9cd15d3e659b618b44cfe3eaec
ToppCell	Caecum-B_cell-B_cell_cycling\|Caecum / Region, Cell class and subclass	ESCO2 CENPE SPP1 TPX2	4.71e-05	198	45	4	61294fe99a5641ad359796022c3d038470076b3c
ToppCell	normal_Lymph_Node-T/NK_cells-Undetermined\|T/NK_cells / Location, Cell class and cell subclass	ESCO2 CENPE RBBP8 TPX2	4.71e-05	198	45	4	47d572b9db2843aeb2079f33a852babf67270be4
ToppCell	Caecum-B_cell-B_cell_cycling\|B_cell / Region, Cell class and subclass	ESCO2 CENPE SPP1 TPX2	4.71e-05	198	45	4	d2def132f3efe9305a5501a96ec82efb1f02c3f7
ToppCell	severe-Lymphocytic-Prol._cells\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	ESCO2 CENPE RBBP8 TPX2	4.71e-05	198	45	4	4d8591eabb543ed789f963b507a07c560c76a7c9
ToppCell	(0)_NK_cells-(0)_NK_Dividing\|(0)_NK_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	ESCO2 CENPE RBBP8 TPX2	4.71e-05	198	45	4	d9cdbc7d420472cb1ffb36ad9c8e53a61b7dbdeb
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like_Prolif\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ESCO2 RCN2 MAP2 TPX2	4.71e-05	198	45	4	06888fe2d42ac66ac12157608becd42764e0d034
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like_Prolif-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ESCO2 RCN2 MAP2 TPX2	4.71e-05	198	45	4	cd876fba12ff30b74aa507286cb1f3a867011a92
ToppCell	(2)_Fibroblasts-(23)_Fibro-4\|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis	HSP90B1 HTRA1 KCNQ5 SPP1	4.71e-05	198	45	4	e0ef49ec0f87cc87b45efa297b9ff6c35b7a2ba9
ToppCell	Caecum-(2)_B_cell-(24)_B_cell_cycling\|Caecum / shred on region, Cell_type, and subtype	ESCO2 CENPE SPP1 TPX2	4.71e-05	198	45	4	568d47770cd20c6569ca84ea1eafde367642d68b
ToppCell	PBMC-Severe-Lymphocyte-B-Plasmablast-Plasmablast-Developping_Plasmablast\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ESCO2 HSP90B1 CENPE TPX2	4.71e-05	198	45	4	2d8d4eb21b4fe3cc178b3518b3ea39c2d9650f24
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Prolif_T-F_2\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ESCO2 CENPE RBBP8 TPX2	4.71e-05	198	45	4	bcfe7b6d91f2e2f145cb2660b65fd2a6c1134b86
ToppCell	T_cells-GZMK+GZMB+_T_cells\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	ESCO2 CENPE RBBP8 TPX2	4.71e-05	198	45	4	085ba270f9defbf5ef45108c6d870e1d7c428479
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ESCO2 CENPE RBBP8 TPX2	4.80e-05	199	45	4	123fbf2122aa221d8cbf3aef9361ba0982c07695
ToppCell	Non-neuronal-Dividing-IPC-IPC-div1-28\|World / Primary Cells by Cluster	ESCO2 HSP90B1 CENPE TPX2	4.80e-05	199	45	4	787688b68ae5d8768c0a24673ae07ab07616764a
ToppCell	COVID-19_Mild-T/NK_proliferative\|COVID-19_Mild / Disease condition and Cell class	ESCO2 CENPE RBBP8 TPX2	4.80e-05	199	45	4	9f9a88d2b099646c1e1a7ee3f8d39cb1a2498ad7
ToppCell	Fibroblasts-CD34+_Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	HTRA1 PLPP1 SDC2 RETREG1	4.80e-05	199	45	4	13ff7409e200a0b46cdb7924d15ef33639693622
ToppCell	(10)_Ciliated-(2)_GFP_FOXI1\|(10)_Ciliated / shred by cell type by condition	ANKRD11 NIPBL BCLAF1 KRCC1	4.80e-05	199	45	4	61b1ed2db71b96157b92b7535d1955a4033098da
ToppCell	Mild/Remission-Developping_Plasmablast\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	ESCO2 HSP90B1 CENPE TPX2	4.80e-05	199	45	4	58c772ec763109a4009f52424fbb214fc23d0c09
ToppCell	COVID-19_Severe-Lymphoid_T/NK-T/NK_proliferative\|COVID-19_Severe / Disease group, lineage and cell class	ESCO2 CENPE RBBP8 TPX2	4.80e-05	199	45	4	ddae7fe7633661f15d3c79f5187415ffbfecce67
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RCN2 HTRA1 PLPP1 SDC2	4.80e-05	199	45	4	84545ced0c792bc77980a50d65e484eab648d47e
ToppCell	Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	HTRA1 PLPP1 SDC2 RETREG1	4.80e-05	199	45	4	40de6d4a31cf22efa2864f79e4ec8e2b7bfc9d4a
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	ESCO2 CENPE RBBP8 TPX2	4.80e-05	199	45	4	e98ff036d04fc78dffef156bdc0d644532274067
ToppCell	VE-cycling\|VE / Condition, Cell_class and T cell subcluster	ESCO2 CENPE RBBP8 TPX2	4.80e-05	199	45	4	47c47ebc318a0b98841ca2656837bbd068899559
ToppCell	Severe\|World / Disease group and Cell class	CENPE SPP1 RBBP8 TPX2	4.80e-05	199	45	4	b73ae402b258fcc17e6cd6d6045244eccfe38ef8
ToppCell	VE-cycling-\|VE / Condition, Cell_class and T cell subcluster	ESCO2 CENPE RBBP8 TPX2	4.80e-05	199	45	4	c0a67149a19b65b3069dbc5261d81f658e6e39a2
ToppCell	normal_Pleural_Fluid-T/NK_cells-Undetermined\|T/NK_cells / Location, Cell class and cell subclass	ESCO2 CENPE RBBP8 TPX2	4.80e-05	199	45	4	a0c20b97cb38e493b47a06e9501fc165a78c61b2
Disease	vital capacity	AUTS2 HTRA1 NBPF12 KCNQ5 MAP2 RBBP8 PCLO RSRC1 PROC	4.93e-05	1236	42	9	EFO_0004312
Disease	alcohol consumption measurement	ESCO2 ANKRD11 AUTS2 DDX50 RBM27 TOPAZ1 PCLO RSRC1	3.17e-04	1242	42	8	EFO_0007878
Disease	Seckel syndrome	CENPE RBBP8	4.49e-04	22	42	2	C0265202
Disease	Cerebral Hemorrhage	SPP1 ITGB3	7.30e-04	28	42	2	C2937358
Disease	lung adenocarcinoma (is_implicated_in)	ESCO2 HTRA1	2.23e-03	49	42	2	DOID:3910 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SFREEKDRSNKAEKE	ANKRD11	731	Q6UB99
DKEHSKERKSSRSAD	ANKRD11	1261	Q6UB99
KRKKTEEESEHEVSC	RBBP8	446	Q99708
LESDDEKDEHTSKKR	C1orf52	156	Q8N6N3
DAEEESFRKLHLKDK	RCN2	141	Q14257
VEHRERSKFKSERND	RBM27	196	Q9P2N5
KKLVTEHKDTEDFRQ	RBM48	156	Q5RL73
SKEEDKHLKFRISHE	SPP1	291	P10451
TSDKKSREKITAEHE	KCNQ5	581	Q9NR82
KDHKEKSEFVDDITT	PCLO	1491	Q9Y6V0
EKKELSEDIRRTHDA	EVPL	886	Q92817
SDEAFESSRKRHKKD	NIPBL	1096	Q6KC79
DKRDSSVSKDDKERE	AUTS2	831	Q8WXX7
EKDKPKERERDHSES	AUTS2	886	Q8WXX7
KERERDHSESRKDLA	AUTS2	891	Q8WXX7
DDTARKEKTDHFIFT	LRRC42	61	Q9Y546
HRKTKITFEEDKVDS	NBPF1	766	Q3BBV0
EKKRSHLKRDTEDQE	PROC	191	P04070
VKFDESEKTKESREA	HSP90B1	596	P14625
SEKTKESREAVEKEF	HSP90B1	601	P14625
KHDRKSKRLDEEEED	EIF3C	281	Q99613
KHDRKSKRLDEEEEE	EIF3CL	281	B5ME19
TSSKAKELKDRHRDF	HTRA1	391	Q92743
SIKSRFTDDDKTDHL	ARHGDIA	176	P52565
HKNLDAREKSTFREE	BCLAF1	516	Q9NYF8
EKESKKEREEEFKTH	BCLAF1	766	Q9NYF8
LSDEFSKSHKSRRKD	DDX50	81	Q9BQ39
KEEETFKRKHEELDR	CCDC57	276	Q2TAC2
IKDSSDDRVSSKEHK	ESCO2	286	Q56NI9
TIHDRKEFAKFEEER	ITGB3	746	P05106
SEEERSKHKRKKSCE	KRCC1	171	Q9NPI7
ETDKEKVHLSDSERK	SDC2	106	P34741
EKDKLFSEVVHKESR	CENPE	776	Q02224
ENEHFRDKSELEDKK	PNPLA8	226	Q9NP80
HRKTKITFEEDKVDS	NBPF12	766	Q5TAG4
RERSEADKEKSHKDD	RETREG1	266	Q9H6L5
KERTSFKERKEEDSH	PLPP1	251	O14494
DKVKEPRKSRDSESH	SAFB	606	Q15424
KRHSRKSEDFVKDSE	USP42	1241	Q9H9J4
AKKSTEEEHKEVFRA	REV1	861	Q9UBZ9
DSIFKKRKDDEDSFR	XRN2	401	Q9H0D6
DDTEKFKEAIVKFHR	TBC1D9	136	Q6ZT07
DRDRKSREEGHKDKE	PHF3	1956	Q92576
SDTEEESRSKRKKKH	RSRC1	6	Q96IZ7
EKAEKEARRSSLEKH	MAP2	1411	P11137
DLDEKHRFTDKVITK	TOPAZ1	981	Q8N9V7
TFSKDEELRKEQRTH	ZNF594	741	Q96JF6
AREEEEKRKEITSHF	TXLNB	236	Q8N3L3
RKDSDKSRSRKDDDS	ZNF740	56	Q8NDX6
IQERESKKKTEDEHF	TPX2	441	Q9ULW0
SKKKTEDEHFEFHSR	TPX2	446	Q9ULW0