Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	serpin family protein binding	CTSL CTSV	1.76e-06	2	27	2	GO:0097655
GeneOntologyMolecularFunction	cysteine-type endopeptidase activator activity involved in apoptotic process	CTSL CTSV CTSS	7.87e-06	29	27	3	GO:0008656
GeneOntologyMolecularFunction	cysteine-type carboxypeptidase activity	CTSL CTSV	1.05e-05	4	27	2	GO:0016807
GeneOntologyMolecularFunction	peptidase activator activity involved in apoptotic process	CTSL CTSV CTSS	1.07e-05	32	27	3	GO:0016505
GeneOntologyMolecularFunction	kininogen binding	CTSL CTSV	1.76e-05	5	27	2	GO:0030984
GeneOntologyMolecularFunction	fibronectin binding	CTSL CTSV CTSS	1.80e-05	38	27	3	GO:0001968
GeneOntologyMolecularFunction	proteoglycan binding	CTSL CTSV CTSS	4.40e-05	51	27	3	GO:0043394
GeneOntologyMolecularFunction	cysteine-type endopeptidase regulator activity involved in apoptotic process	CTSL CTSV CTSS	5.22e-05	54	27	3	GO:0043028
GeneOntologyMolecularFunction	cysteine-type exopeptidase activity	CTSL CTSV	7.87e-05	10	27	2	GO:0070004
GeneOntologyMolecularFunction	peptidase activator activity	CTSL CTSV CTSS	1.14e-04	70	27	3	GO:0016504
GeneOntologyMolecularFunction	collagen binding	CTSL CTSV CTSS	1.75e-04	81	27	3	GO:0005518
GeneOntologyMolecularFunction	enzyme activator activity	ARAP3 RALGAPA2 CTSL CTSV CTSS TBC1D5	2.02e-04	656	27	6	GO:0008047
GeneOntologyMolecularFunction	cysteine-type endopeptidase activity	CTSL CTSV CTSS	2.09e-04	86	27	3	GO:0004197
GeneOntologyMolecularFunction	enzyme regulator activity	ARAP3 HERC1 RALGAPA2 MYCBP2 CTSL CTSV CTSS TBC1D5	4.15e-04	1418	27	8	GO:0030234
GeneOntologyMolecularFunction	GTPase regulator activity	ARAP3 HERC1 RALGAPA2 MYCBP2 TBC1D5	5.26e-04	507	27	5	GO:0030695
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	ARAP3 HERC1 RALGAPA2 MYCBP2 TBC1D5	5.26e-04	507	27	5	GO:0060589
GeneOntologyMolecularFunction	aminopeptidase activity	CTSL CTSV	1.54e-03	43	27	2	GO:0004177
GeneOntologyMolecularFunction	4 iron, 4 sulfur cluster binding	RTEL1 SDHB	1.83e-03	47	27	2	GO:0051539
GeneOntologyMolecularFunction	carboxypeptidase activity	CTSL CTSV	1.99e-03	49	27	2	GO:0004180
GeneOntologyMolecularFunction	cysteine-type peptidase activity	CTSL CTSV CTSS	2.16e-03	192	27	3	GO:0008234
GeneOntologyMolecularFunction	peptidase regulator activity	CTSL CTSV CTSS	4.91e-03	257	27	3	GO:0061134
GeneOntologyMolecularFunction	iron-sulfur cluster binding	RTEL1 SDHB	4.96e-03	78	27	2	GO:0051536
GeneOntologyMolecularFunction	molecular function activator activity	ARAP3 RALGAPA2 CTSL CTSV CTSS TBC1D5	5.28e-03	1233	27	6	GO:0140677
GeneOntologyMolecularFunction	histone binding	TDRD3 CTSL CTSV	5.34e-03	265	27	3	GO:0042393
GeneOntologyMolecularFunction	metal cluster binding	RTEL1 SDHB	5.60e-03	83	27	2	GO:0051540
GeneOntologyMolecularFunction	GTPase activator activity	ARAP3 RALGAPA2 TBC1D5	6.16e-03	279	27	3	GO:0005096
GeneOntologyMolecularFunction	voltage-gated potassium channel activity	KCNK12 KCNA6	8.35e-03	102	27	2	GO:0005249
GeneOntologyMolecularFunction	peptide binding	CTSL CTSV GALR2	8.82e-03	318	27	3	GO:0042277
GeneOntologyMolecularFunction	exopeptidase activity	CTSL CTSV	9.65e-03	110	27	2	GO:0008238
GeneOntologyBiologicalProcess	antigen processing and presentation of exogenous peptide antigen via MHC class II	CTSL CTSV CTSS	9.67e-06	32	27	3	GO:0019886
GeneOntologyBiologicalProcess	antigen processing and presentation of peptide antigen via MHC class II	CTSL CTSV CTSS	1.39e-05	36	27	3	GO:0002495
GeneOntologyBiologicalProcess	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	CTSL CTSV CTSS	1.64e-05	38	27	3	GO:0002504
GeneOntologyBiologicalProcess	antigen processing and presentation	RFTN1 CTSL CTSV CTSS	3.07e-05	139	27	4	GO:0019882
GeneOntologyBiologicalProcess	antigen processing and presentation of exogenous peptide antigen	CTSL CTSV CTSS	3.33e-05	48	27	3	GO:0002478
GeneOntologyBiologicalProcess	positive regulation of hydrolase activity	ARAP3 RALGAPA2 CTSL CTSV CTSS TBC1D5	3.74e-05	499	27	6	GO:0051345
GeneOntologyBiologicalProcess	collagen catabolic process	CTSL CTSV CTSS	4.49e-05	53	27	3	GO:0030574
GeneOntologyBiologicalProcess	antigen processing and presentation of exogenous antigen	CTSL CTSV CTSS	5.88e-05	58	27	3	GO:0019884
GeneOntologyBiologicalProcess	catagen	CTSL CTSV	5.91e-05	9	27	2	GO:0042637
GeneOntologyBiologicalProcess	elastin catabolic process	CTSL CTSV	7.38e-05	10	27	2	GO:0060309
GeneOntologyBiologicalProcess	antigen processing and presentation of peptide antigen	CTSL CTSV CTSS	1.32e-04	76	27	3	GO:0048002
GeneOntologyBiologicalProcess	elastin metabolic process	CTSL CTSV	1.49e-04	14	27	2	GO:0051541
GeneOntologyBiologicalProcess	hair cycle phase	CTSL CTSV	4.10e-04	23	27	2	GO:0044851
GeneOntologyBiologicalProcess	thyroid hormone generation	CTSL CTSV	4.86e-04	25	27	2	GO:0006590
GeneOntologyBiologicalProcess	auditory receptor cell stereocilium organization	TRIOBP TECTA	5.26e-04	26	27	2	GO:0060088
GeneOntologyBiologicalProcess	hair follicle maturation	CTSL CTSV	6.56e-04	29	27	2	GO:0048820
GeneOntologyBiologicalProcess	negative regulation of keratinocyte proliferation	CTSL CTSV	6.56e-04	29	27	2	GO:0010839
GeneOntologyBiologicalProcess	auditory receptor cell morphogenesis	TRIOBP TECTA	7.50e-04	31	27	2	GO:0002093
GeneOntologyBiologicalProcess	CD4-positive, alpha-beta T cell lineage commitment	CTSL CTSV	7.50e-04	31	27	2	GO:0043373
GeneOntologyBiologicalProcess	regulation of hydrolase activity	ARAP3 RALGAPA2 CTSL CTSV CTSS TBC1D5	8.03e-04	878	27	6	GO:0051336
GeneOntologyBiologicalProcess	decidualization	CTSL CTSV	8.50e-04	33	27	2	GO:0046697
GeneOntologyBiologicalProcess	alpha-beta T cell lineage commitment	CTSL CTSV	8.50e-04	33	27	2	GO:0002363
GeneOntologyBiologicalProcess	thyroid hormone metabolic process	CTSL CTSV	9.02e-04	34	27	2	GO:0042403
GeneOntologyBiologicalProcess	collagen metabolic process	CTSL CTSV CTSS	9.33e-04	148	27	3	GO:0032963
GeneOntologyBiologicalProcess	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	CTSL CTSV	9.56e-04	35	27	2	GO:0043369
GeneOntologyBiologicalProcess	auditory receptor cell development	TRIOBP TECTA	1.25e-03	40	27	2	GO:0060117
GeneOntologyBiologicalProcess	hair follicle morphogenesis	CTSL CTSV	1.25e-03	40	27	2	GO:0031069
GeneOntologyBiologicalProcess	organic hydroxy compound metabolic process	PLB1 ARV1 CTSL CTSV GALR2	1.31e-03	641	27	5	GO:1901615
GeneOntologyBiologicalProcess	epithelial tube branching involved in lung morphogenesis	CTSL CTSV	1.31e-03	41	27	2	GO:0060441
GeneOntologyBiologicalProcess	glycoprotein catabolic process	CTSL CTSV	1.31e-03	41	27	2	GO:0006516
GeneOntologyBiologicalProcess	T cell lineage commitment	CTSL CTSV	1.38e-03	42	27	2	GO:0002360
GeneOntologyBiologicalProcess	positive regulation of apoptotic signaling pathway	CTSL CTSV CTSS	1.49e-03	174	27	3	GO:2001235
GeneOntologyBiologicalProcess	maternal placenta development	CTSL CTSV	1.51e-03	44	27	2	GO:0001893
GeneOntologyBiologicalProcess	epidermis morphogenesis	CTSL CTSV	1.65e-03	46	27	2	GO:0048730
GeneOntologyBiologicalProcess	positive regulation of catalytic activity	ARAP3 RALGAPA2 CTSL CTSV CTSS TBC1D5	1.81e-03	1028	27	6	GO:0043085
GeneOntologyBiologicalProcess	positive regulation of molecular function	ARAP3 RALGAPA2 CTSL CTSV GALR2 CTSS TBC1D5	1.97e-03	1430	27	7	GO:0044093
GeneOntologyBiologicalProcess	positive regulation of peptidase activity	CTSL CTSV CTSS	1.97e-03	192	27	3	GO:0010952
GeneOntologyBiologicalProcess	inner ear receptor cell stereocilium organization	TRIOBP TECTA	2.18e-03	53	27	2	GO:0060122
GeneOntologyBiologicalProcess	positive T cell selection	CTSL CTSV	2.18e-03	53	27	2	GO:0043368
GeneOntologyBiologicalProcess	biological phase	CTSL CTSV	2.18e-03	53	27	2	GO:0044848
GeneOntologyBiologicalProcess	positive regulation of cation channel activity	GALR2 CTSS	2.43e-03	56	27	2	GO:2001259
GeneOntologyBiologicalProcess	regulation of keratinocyte proliferation	CTSL CTSV	2.43e-03	56	27	2	GO:0010837
GeneOntologyCellularComponent	endolysosome lumen	CTSL CTSS	1.60e-05	5	27	2	GO:0036021
GeneOntologyCellularComponent	lysosomal lumen	CTSL CTSV CTSS	2.69e-04	98	27	3	GO:0043202
GeneOntologyCellularComponent	endolysosome	CTSL CTSS	6.83e-04	30	27	2	GO:0036019
GeneOntologyCellularComponent	endosome lumen	CTSL CTSS	1.40e-03	43	27	2	GO:0031904
GeneOntologyCellularComponent	vacuolar lumen	CTSL CTSV CTSS	1.53e-03	178	27	3	GO:0005775
HumanPheno	Expressive language delay	KMT2C HERC1 SDHB	6.78e-05	56	8	3	HP:0002474
HumanPheno	Language delay	KMT2C HERC1 SDHB	6.78e-05	56	8	3	HP:0002336
HumanPheno	Severe expressive language delay	KMT2C HERC1	1.41e-04	12	8	2	HP:0006863
MousePheno	periodontal ligament necrosis	CTSL CTSV	2.59e-06	2	23	2	MP:0030515
MousePheno	abnormal lymph node medullary sinus morphology	CTSL CTSV	2.59e-06	2	23	2	MP:0011222
MousePheno	dilated lymph node medullary sinus	CTSL CTSV	2.59e-06	2	23	2	MP:0011223
MousePheno	insulitis	CTSL CTSV CTSS	9.87e-06	26	23	3	MP:0004031
MousePheno	folliculitis	CTSL CTSV	2.58e-05	5	23	2	MP:0000376
MousePheno	dental pulp necrosis	CTSL CTSV	2.58e-05	5	23	2	MP:0013251
MousePheno	hair follicle outer root sheath hyperplasia	CTSL CTSV	2.58e-05	5	23	2	MP:0010688
MousePheno	enlarged thymus cortex	CTSL CTSV	2.58e-05	5	23	2	MP:0013593
MousePheno	salivary gland inflammation	CTSL CTSV CTSS	3.16e-05	38	23	3	MP:0001870
MousePheno	decreased susceptibility to autoimmune diabetes	CTSL CTSV CTSS	5.28e-05	45	23	3	MP:0004804
MousePheno	mitral valve regurgitation	CTSL CTSV	5.41e-05	7	23	2	MP:0006045
MousePheno	abnormal R wave	CTSL CTSV	5.41e-05	7	23	2	MP:0011919
MousePheno	dilated piliary canal	CTSL CTSV	7.21e-05	8	23	2	MP:0030571
MousePheno	sparse vibrissae	CTSL CTSV	7.21e-05	8	23	2	MP:0001283
MousePheno	abnormal hair cycle catagen phase	CTSL CTSV	9.26e-05	9	23	2	MP:0008859
MousePheno	abnormal T wave	CTSL CTSV	9.26e-05	9	23	2	MP:0010505
MousePheno	increased heart left atrium size	CTSL CTSV	9.26e-05	9	23	2	MP:0008726
MousePheno	hypergranulosis	CTSL CTSV	9.26e-05	9	23	2	MP:0009600
MousePheno	focal dorsal hair loss	CTSL CTSV	9.26e-05	9	23	2	MP:0010202
MousePheno	abnormal salivary gland physiology	CTSL CTSV CTSS	1.13e-04	58	23	3	MP:0005310
MousePheno	abnormal lymph node medulla morphology	CTSL CTSV	1.16e-04	10	23	2	MP:0002348
MousePheno	abnormal susceptibility to autoimmune disorder	MUC19 RFTN1 CTSL CTSV CTSS	1.20e-04	307	23	5	MP:0002425
MousePheno	abnormal merocrine gland physiology	CTSL CTSV CTSS	1.25e-04	60	23	3	MP:0013557
MousePheno	abnormal piliary canal morphology	CTSL CTSV	1.69e-04	12	23	2	MP:0030570
MousePheno	thick epidermis stratum granulosum	CTSL CTSV	1.69e-04	12	23	2	MP:0009599
MousePheno	lymph node inflammation	CTSL CTSV	1.69e-04	12	23	2	MP:0003865
MousePheno	abnormal dental pulp morphology	CTSL CTSV	1.69e-04	12	23	2	MP:0013250
MousePheno	abnormal CD4-positive T cell differentiation	RFTN1 CTSL CTSV	1.90e-04	69	23	3	MP:0008076
MousePheno	decreased susceptibility to autoimmune disorder	RFTN1 CTSL CTSV CTSS	1.94e-04	180	23	4	MP:0005351
MousePheno	aortic valve regurgitation	CTSL CTSV	2.00e-04	13	23	2	MP:0006047
MousePheno	atrioventricular valve regurgitation	CTSL CTSV	2.00e-04	13	23	2	MP:0006046
MousePheno	abnormal periodontal ligament morphology	CTSL CTSV	2.00e-04	13	23	2	MP:0003668
MousePheno	increased circulating glucose level	TRIOBP HERC1 CTSL CTSV CTSS SDHB	2.12e-04	553	23	6	MP:0005559
MousePheno	pancreas inflammation	CTSL CTSV CTSS	2.15e-04	72	23	3	MP:0001869
MousePheno	abnormal vibrissa morphology	TRIOBP ARAP3 CTSL CTSV	2.16e-04	185	23	4	MP:0002098
MousePheno	excessive scratching	CTSL CTSV	2.68e-04	15	23	2	MP:0001412
MousePheno	absent vibrissae	TRIOBP CTSL CTSV	3.05e-04	81	23	3	MP:0001284
MousePheno	abnormal hair follicle outer root sheath morphology	CTSL CTSV	3.06e-04	16	23	2	MP:0010684
MousePheno	abnormal dental pulp cavity morphology	CTSL CTSV	3.06e-04	16	23	2	MP:0002819
MousePheno	orthokeratosis	CTSL CTSV	3.06e-04	16	23	2	MP:0009675
MousePheno	short hair	CTSL CTSV	3.06e-04	16	23	2	MP:0000417
MousePheno	abnormal thymus corticomedullary boundary morphology	CTSL CTSV	3.47e-04	17	23	2	MP:0009543
MousePheno	greasy coat	CTSL CTSV	3.47e-04	17	23	2	MP:0003849
MousePheno	semilunar valve regurgitation	CTSL CTSV	3.90e-04	18	23	2	MP:0006049
MousePheno	autoimmune response	MUC19 RFTN1 CTSL CTSV CTSS	4.02e-04	398	23	5	MP:0001844
MousePheno	abnormal self tolerance	MUC19 RFTN1 CTSL CTSV CTSS	4.11e-04	400	23	5	MP:0005005
MousePheno	abnormal immune tolerance	MUC19 RFTN1 CTSL CTSV CTSS	4.30e-04	404	23	5	MP:0005000
MousePheno	abnormal external auditory canal morphology	CTSL CTSV	4.35e-04	19	23	2	MP:0006033
MousePheno	abnormal hair follicle orientation	CTSL CTSV	4.35e-04	19	23	2	MP:0000383
MousePheno	delayed hair appearance	CTSL CTSV	4.35e-04	19	23	2	MP:0000422
MousePheno	short vibrissae	CTSL CTSV	4.83e-04	20	23	2	MP:0001282
MousePheno	underdeveloped hair follicles	CTSL CTSV	5.34e-04	21	23	2	MP:0000382
MousePheno	thick dermal layer	CTSL CTSV	5.86e-04	22	23	2	MP:0001245
MousePheno	abnormal heart left atrium morphology	CTSL CTSV	5.86e-04	22	23	2	MP:0003923
MousePheno	enlarged sebaceous gland	CTSL CTSV	6.42e-04	23	23	2	MP:0000652
MousePheno	hyperglycemia	CTSL CTSV CTSS	6.54e-04	105	23	3	MP:0001559
MousePheno	shiny skin	CTSL CTSV	6.99e-04	24	23	2	MP:0001196
MousePheno	rough coat	CTSL CTSV	6.99e-04	24	23	2	MP:0010179
MousePheno	increased central memory CD4-positive, alpha-beta T cell number	CTSL CTSV	6.99e-04	24	23	2	MP:0010841
MousePheno	cardiac valve regurgitation	CTSL CTSV	8.22e-04	26	23	2	MP:0009384
MousePheno	increased keratinocyte proliferation	CTSL CTSV	8.86e-04	27	23	2	MP:0009583
MousePheno	abnormal central memory CD4-positive, alpha-beta T cell number	CTSL CTSV	1.10e-03	30	23	2	MP:0012771
MousePheno	abnormal central memory CD4-positive, alpha-beta T cell morphology	CTSL CTSV	1.10e-03	30	23	2	MP:0010840
MousePheno	abnormal heart valve physiology	CTSL CTSV	1.10e-03	30	23	2	MP:0011926
MousePheno	lymph node hyperplasia	CTSL CTSV	1.33e-03	33	23	2	MP:0008102
MousePheno	abnormal periodontium morphology	CTSL CTSV	1.41e-03	34	23	2	MP:0030131
MousePheno	increased central memory CD8 positive, alpha-beta T cell number	CTSL CTSV	1.49e-03	35	23	2	MP:0010847
MousePheno	amyloidosis	CTSL CTSV	1.49e-03	35	23	2	MP:0000604
MousePheno	abnormal amyloid deposition	CTSL CTSV	1.49e-03	35	23	2	MP:0021152
MousePheno	granulomatous inflammation	CTSL CTSV	1.58e-03	36	23	2	MP:0002500
MousePheno	abnormal CD8-positive, alpha-beta T cell differentiation	CTSL CTSV	1.67e-03	37	23	2	MP:0008080
MousePheno	abnormal epidermis stratum basale morphology	CTSL CTSV	1.67e-03	37	23	2	MP:0001231
MousePheno	abnormal brain interneuron morphology	TARDBP MYCBP2	1.67e-03	37	23	2	MP:0004101
MousePheno	abnormal cochlear hair cell physiology	TRIOBP TECTA	1.94e-03	40	23	2	MP:0004432
MousePheno	abnormal keratinocyte proliferation	CTSL CTSV	2.04e-03	41	23	2	MP:0009582
MousePheno	increased effector memory CD4-positive, alpha-beta T cell number	CTSL CTSV	2.04e-03	41	23	2	MP:0010844
MousePheno	abnormal central memory CD8-positive, alpha-beta T cell number	CTSL CTSV	2.14e-03	42	23	2	MP:0012772
MousePheno	abnormal central memory CD8 positive, alpha-beta T cell morphology	CTSL CTSV	2.14e-03	42	23	2	MP:0010846
MousePheno	acanthosis	CTSL CTSV	2.24e-03	43	23	2	MP:0001874
MousePheno	focal hair loss	CTSL CTSV	2.24e-03	43	23	2	MP:0000418
MousePheno	abnormal circulating glucose level	TRIOBP HERC1 ARV1 CTSL CTSV CTSS SDHB	2.29e-03	1188	23	7	MP:0000188
MousePheno	decreased long bone epiphyseal plate size	CTSL CTSV	2.35e-03	44	23	2	MP:0006396
MousePheno	epidermis stratum spinosum hyperplasia	CTSL CTSV	2.46e-03	45	23	2	MP:0009611
MousePheno	increased heart atrium size	CTSL CTSV	2.56e-03	46	23	2	MP:0008725
MousePheno	abnormal effector memory CD4-positive, alpha-beta T cell number	CTSL CTSV	2.79e-03	48	23	2	MP:0012770
MousePheno	abnormal effector memory CD4-positive, alpha-beta T cell morphology	CTSL CTSV	2.79e-03	48	23	2	MP:0010843
MousePheno	hearing/vestibular/ear phenotype	TRIOBP HERC1 TECTA ARV1 CTSL CTSV	2.82e-03	905	23	6	MP:0005377
MousePheno	abnormal hair cell physiology	TRIOBP TECTA	2.91e-03	49	23	2	MP:0003879
MousePheno	abnormal heart echocardiography feature	CTSL CTSV	2.91e-03	49	23	2	MP:0011925
MousePheno	abnormal ligament morphology	CTSL CTSV	2.91e-03	49	23	2	MP:0005504
MousePheno	cardiac interstitial fibrosis	CTSL CTSV	3.02e-03	50	23	2	MP:0005608
MousePheno	abnormal lymph node cortex morphology	CTSL CTSV	3.02e-03	50	23	2	MP:0002343
MousePheno	decreased thyroxine level	CTSL CTSV	3.14e-03	51	23	2	MP:0005471
MousePheno	thick skin	CTSL CTSV	3.27e-03	52	23	2	MP:0001200
MousePheno	abnormal thymus cortex morphology	CTSL CTSV	3.27e-03	52	23	2	MP:0002371
Domain	Inhibitor_I29	CTSL CTSV CTSS	9.39e-08	7	27	3	PF08246
Domain	Prot_inhib_I29	CTSL CTSV CTSS	9.39e-08	7	27	3	IPR013201
Domain	Inhibitor_I29	CTSL CTSV CTSS	9.39e-08	7	27	3	SM00848
Domain	Pept_asp_AS	CTSL CTSV CTSS	3.21e-07	10	27	3	IPR025661
Domain	Pept_his_AS	CTSL CTSV CTSS	4.41e-07	11	27	3	IPR025660
Domain	Pept_C1	CTSL CTSV CTSS	7.63e-07	13	27	3	SM00645
Domain	Peptidase_C1A_C	CTSL CTSV CTSS	7.63e-07	13	27	3	IPR000668
Domain	Peptidase_C1	CTSL CTSV CTSS	7.63e-07	13	27	3	PF00112
Domain	Peptidase_C1A	CTSL CTSV CTSS	7.63e-07	13	27	3	IPR013128
Domain	THIOL_PROTEASE_CYS	CTSL CTSV CTSS	6.85e-06	26	27	3	PS00139
Domain	THIOL_PROTEASE_ASN	CTSL CTSV CTSS	7.70e-06	27	27	3	PS00640
Domain	THIOL_PROTEASE_HIS	CTSL CTSV CTSS	7.70e-06	27	27	3	PS00639
Domain	Pept_cys_AS	CTSL CTSV CTSS	8.62e-06	28	27	3	IPR000169
Domain	TIL	MUC19 TECTA	1.32e-04	12	27	2	PF01826
Domain	C8	MUC19 TECTA	1.32e-04	12	27	2	PF08742
Domain	Unchr_dom_Cys-rich	MUC19 TECTA	1.55e-04	13	27	2	IPR014853
Domain	C8	MUC19 TECTA	1.55e-04	13	27	2	SM00832
Domain	TIL_dom	MUC19 TECTA	1.81e-04	14	27	2	IPR002919
Domain	VWFD	MUC19 TECTA	2.39e-04	16	27	2	PS51233
Domain	VWD	MUC19 TECTA	2.39e-04	16	27	2	SM00216
Domain	VWF_type-D	MUC19 TECTA	2.39e-04	16	27	2	IPR001846
Domain	VWD	MUC19 TECTA	2.39e-04	16	27	2	PF00094
Domain	VWC_out	MUC19 TECTA	3.39e-04	19	27	2	SM00215
Domain	RCC1	HERC1 MYCBP2	3.76e-04	20	27	2	PF00415
Domain	RCC1_3	HERC1 MYCBP2	4.16e-04	21	27	2	PS50012
Domain	RCC1_1	HERC1 MYCBP2	4.16e-04	21	27	2	PS00625
Domain	RCC1_2	HERC1 MYCBP2	4.16e-04	21	27	2	PS00626
Domain	Reg_chr_condens	HERC1 MYCBP2	4.57e-04	22	27	2	IPR000408
Domain	-	HERC1 MYCBP2	4.57e-04	22	27	2	2.130.10.30
Domain	RCC1/BLIP-II	HERC1 MYCBP2	5.00e-04	23	27	2	IPR009091
Domain	VWC	MUC19 TECTA	1.37e-03	38	27	2	SM00214
Domain	VWFC_2	MUC19 TECTA	1.37e-03	38	27	2	PS50184
Domain	VWF_dom	MUC19 TECTA	1.67e-03	42	27	2	IPR001007
Domain	SAM	BFAR ARAP3	7.14e-03	88	27	2	SM00454
Domain	SAM_DOMAIN	BFAR ARAP3	8.27e-03	95	27	2	PS50105
Domain	SAM	BFAR ARAP3	8.61e-03	97	27	2	IPR001660
Domain	ZF_RING_2	KMT2C BFAR MYCBP2	8.86e-03	298	27	3	PS50089
Pathway	REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY	CTSL CTSV CTSS	4.67e-07	11	21	3	M525
Pathway	REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR	CTSL CTSV CTSS	8.07e-07	13	21	3	M593
Pathway	REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR	CTSL CTSV CTSS	8.07e-07	13	21	3	MM14659
Pathway	KEGG_LYSOSOME	NAGPA CTSL CTSV CTSS	2.76e-05	121	21	4	M11266
Pathway	REACTOME_ASSEMBLY_OF_COLLAGEN_FIBRILS_AND_OTHER_MULTIMERIC_STRUCTURES	CTSL CTSV CTSS	5.34e-05	50	21	3	MM14796
Pathway	REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_KERATINOCYTES	CTSL CTSV	5.89e-05	8	21	2	M27796
Pathway	REACTOME_ASSEMBLY_OF_COLLAGEN_FIBRILS_AND_OTHER_MULTIMERIC_STRUCTURES	CTSL CTSV CTSS	9.70e-05	61	21	3	M27103
Pathway	REACTOME_COLLAGEN_FORMATION	CTSL CTSV CTSS	1.87e-04	76	21	3	MM14573
Pathway	REACTOME_COLLAGEN_FORMATION	CTSL CTSV CTSS	3.08e-04	90	21	3	M631
Pathway	REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION	CTSL CTSV CTSS	4.98e-04	106	21	3	M518
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	CTSL CTSV CTSS	6.16e-04	114	21	3	MM14571
Pathway	REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION	CTSL CTSV CTSS	6.48e-04	116	21	3	MM14855
Pathway	REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION	CTSL CTSV CTSS	8.24e-04	126	21	3	M705
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	CTSL CTSV CTSS	1.12e-03	140	21	3	M587
Pathway	REACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES	CTSL CTSV	1.44e-03	38	21	2	MM14611
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_CASCADES	CTSL CTSV CTSS	1.50e-03	155	21	3	MM14665
Pathway	REACTOME_TOLL_LIKE_RECEPTOR_CASCADES	CTSL CTSV CTSS	1.95e-03	170	21	3	M7494
Pathway	REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION	HERC1 CTSL CTSV CTSS	2.18e-03	381	21	4	M1066
Pathway	WP_ENDOCHONDRAL_OSSIFICATION	CTSL CTSV	4.28e-03	66	21	2	MM15875
Pubmed	A role for cathepsin L and cathepsin S in peptide generation for MHC class II presentation.	CTSL CTSV CTSS	4.67e-10	3	28	3	11884425
Pubmed	Cathepsins L and S are not required for activation of dipeptidyl peptidase I (cathepsin C) in mice.	CTSL CTSV CTSS	4.67e-10	3	28	3	16895486
Pubmed	Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation.	CTSL CTSV CTSS	1.87e-09	4	28	3	31932607
Pubmed	Redundancy between Cysteine Cathepsins in Murine Experimental Autoimmune Encephalomyelitis.	CTSL CTSV CTSS	1.87e-09	4	28	3	26075905
Pubmed	Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis.	CTSL CTSV CTSS	1.87e-09	4	28	3	19640986
Pubmed	Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse.	CTSL CTSV CTSS	1.87e-09	4	28	3	19664906
Pubmed	Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological disease.	CTSL CTSV CTSS	1.87e-09	4	28	3	16508006
Pubmed	Protease cleavage sites in HIV-1 gp120 recognized by antigen processing enzymes are conserved and located at receptor binding sites.	CTSL CTSV CTSS	1.87e-09	4	28	3	19939935
Pubmed	Lack of cathepsin activities alter or prevent the development of lung granulomas in a mouse model of sarcoidosis.	CTSL CTSV CTSS	1.87e-09	4	28	3	21251246
Pubmed	Cathepsin expression during skeletal development.	CTSL CTSV CTSS	4.67e-09	5	28	3	10395917
Pubmed	Distinct roles for cysteine cathepsin genes in multistage tumorigenesis.	CTSL CTSV CTSS	4.67e-09	5	28	3	16481467
Pubmed	Multiple sites on SARS-CoV-2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V.	CTSL CTSV CTSS	4.67e-09	5	28	3	33786919
Pubmed	Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation.	CTSL CTSV CTSS	4.67e-09	5	28	3	12186844
Pubmed	Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice.	CTSL CTSV CTSS	4.67e-09	5	28	3	15905550
Pubmed	Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo.	CTSL CTSV CTSS	4.67e-09	5	28	3	15308097
Pubmed	Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages.	CTSL CTSV CTSS	4.67e-09	5	28	3	10748235
Pubmed	DM, but not cathepsin L, is required to control an aerosol infection with Mycobacterium tuberculosis.	CTSL CTSV CTSS	9.33e-09	6	28	3	18591414
Pubmed	Mouse cathepsin M, a placenta-specific lysosomal cysteine protease related to cathepsins L and P.	CTSL CTSV CTSS	9.33e-09	6	28	3	10760593
Pubmed	IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion.	CTSL CTSV CTSS	9.33e-09	6	28	3	20080943
Pubmed	Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo.	CTSL CTSV CTSS	9.33e-09	6	28	3	24145449
Pubmed	TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors.	CTSL CTSV CTSS	1.63e-08	7	28	3	27477282
Pubmed	Asparagine endopeptidase controls anti-influenza virus immune responses through TLR7 activation.	CTSL CTSV CTSS	2.61e-08	8	28	3	22916010
Pubmed	Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.	CTSL CTSV CTSS	3.91e-08	9	28	3	29909986
Pubmed	Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation.	CTSL CTSV CTSS	5.59e-08	10	28	3	28087651
Pubmed	The genes of the lysosomal cysteine proteinases cathepsin B, H, L, and S map to different mouse chromosomes.	CTSL CTSV CTSS	1.02e-07	12	28	3	9096102
Pubmed	Identification of a membrane-associated cysteine protease with possible dual roles in the endoplasmic reticulum and protein storage vacuole.	CTSL CTSV	6.25e-07	2	28	2	11022031
Pubmed	B-cell lymphopoiesis is regulated by cathepsin L.	CTSL CTSV	6.25e-07	2	28	2	23585893
Pubmed	Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus.	CTSL CTSV	6.25e-07	2	28	2	9545226
Pubmed	Cathepsin L gene expression and promoter activation in rodent granulosa cells.	CTSL CTSV	6.25e-07	2	28	2	14563703
Pubmed	Cathepsin L is crucial for the development of early experimental diabetic nephropathy.	CTSL CTSV	6.25e-07	2	28	2	27575559
Pubmed	Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions.	CTSL CTSV	6.25e-07	2	28	2	19801522
Pubmed	Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L.	CTSL CTSV	6.25e-07	2	28	2	11972068
Pubmed	Identification of procathepsin L (pCTS-L)-neutralizing monoclonal antibodies to treat potentially lethal sepsis.	CTSL CTSV	6.25e-07	2	28	2	36735789
Pubmed	Cathepsin L plays an active role in involution of the mouse mammary gland.	CTSL CTSV	6.25e-07	2	28	2	12815617
Pubmed	Cathepsin L promotes Vascular Intimal Hyperplasia after Arterial Injury.	CTSL CTSV	6.25e-07	2	28	2	28332696
Pubmed	Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8(+) T cell activity.	CTSL CTSV	6.25e-07	2	28	2	20877570
Pubmed	Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.	CTSL CTSV	6.25e-07	2	28	2	19900452
Pubmed	Impaired turnover of autophagolysosomes in cathepsin L deficiency.	CTSL CTSV	6.25e-07	2	28	2	20536383
Pubmed	Response to comment on "Cathepsin-L influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number".	CTSL CTSV	6.25e-07	2	28	2	16621972
Pubmed	Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer Progression.	CTSL CTSV	6.25e-07	2	28	2	25957406
Pubmed	Cathepsin L regulates pathogenicCD4 T cells in experimental autoimmune encephalomyelitis.	CTSL CTSV	6.25e-07	2	28	2	33540247
Pubmed	Expression of cathepsins V and S in thymic epithelial tumors.	CTSV CTSS	6.25e-07	2	28	2	27771373
Pubmed	The protease cathepsin L regulates Th17 cell differentiation.	CTSL CTSV	6.25e-07	2	28	2	26343333
Pubmed	Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice.	CTSL CTSV	6.25e-07	2	28	2	16636100
Pubmed	Cloning, genomic organization, and chromosomal localization of human cathepsin L.	CTSL CTSV	6.25e-07	2	28	2	8419312
Pubmed	Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation.	CTSL CTSV	6.25e-07	2	28	2	31010818
Pubmed	Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages.	CTSL CTSV	6.25e-07	2	28	2	20338168
Pubmed	Thymocyte expression of cathepsin L is essential for NKT cell development.	CTSL CTSV	6.25e-07	2	28	2	12368909
Pubmed	Cloning and characterization of a mouse cysteine proteinase.	CTSL CTSV	6.25e-07	2	28	2	3533924
Pubmed	Surface activation of pro-cathepsin L.	CTSL CTSV	6.25e-07	2	28	2	1482371
Pubmed	Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation.	CTSL CTSV	6.25e-07	2	28	2	12163394
Pubmed	Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice.	CTSL CTSV	6.25e-07	2	28	2	20347002
Pubmed	Cathepsin L coexists with Cytotoxic T-lymphocyte Antigen-2 alpha in distinct regions of the mouse brain.	CTSL CTSV	6.25e-07	2	28	2	27586811
Pubmed	Cathepsin L-deficient mice exhibit abnormal skin and bone development and show increased resistance to osteoporosis following ovariectomy.	CTSL CTSV	6.25e-07	2	28	2	15154914
Pubmed	Cathepsin-L ameliorates cardiac hypertrophy through activation of the autophagy-lysosomal dependent protein processing pathways.	CTSL CTSV	6.25e-07	2	28	2	23608608
Pubmed	Autophagy and cathepsin L are involved in the antinociceptive effect of DMBC in a mouse acetic acid-writhing model.	CTSL CTSV	6.25e-07	2	28	2	23912553
Pubmed	Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs.	CTSL CTSS	6.25e-07	2	28	2	12748383
Pubmed	Developmental expression of cathepsin L and c-rasHa in the mouse placenta.	CTSL CTSV	6.25e-07	2	28	2	1751032
Pubmed	Inhibition of cathepsin L alleviates the microglia-mediated neuroinflammatory responses through caspase-8 and NF-κB pathways.	CTSL CTSV	6.25e-07	2	28	2	29154036
Pubmed	Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity.	MUC19 CTSS	6.25e-07	2	28	2	12163455
Pubmed	Peripheral cathepsin L inhibition induces fat loss in C. elegans and mice through promoting central serotonin synthesis.	CTSL CTSV	6.25e-07	2	28	2	31771567
Pubmed	Cathepsin L Helps to Defend Mice from Infection with Influenza A.	CTSL CTSV	6.25e-07	2	28	2	27716790
Pubmed	The radiation-induced nackt (nkt) allele is a loss-of-function mutation of the mouse cathepsin L gene.	CTSL CTSV	6.25e-07	2	28	2	16393949
Pubmed	Cathepsin L in bone marrow-derived cells is required for retinal and choroidal neovascularization.	CTSL CTSV	6.25e-07	2	28	2	20304958
Pubmed	Characterization and comparative mapping of the porcine CTSL gene indicates a novel synteny between HSA9q21-->q22 and SSC10q11-->q12.	CTSL CTSV	6.25e-07	2	28	2	11978977
Pubmed	Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels.	CTSL CTSV	6.25e-07	2	28	2	2275556
Pubmed	Evolution of placentally expressed cathepsins.	CTSL CTSV	6.25e-07	2	28	2	12054558
Pubmed	The CD4 T cell-deficient mouse mutation nackt (nkt) involves a deletion in the cathepsin L (CtsI) gene.	CTSL CTSV	6.25e-07	2	28	2	11398968
Pubmed	Cathepsin L is involved in proliferation and invasion of breast cancer cells.	CTSL CTSV	6.25e-07	2	28	2	26639231
Pubmed	A variant of pulmonary alveolar microlithiasis in nackt mice.	CTSL CTSV	6.25e-07	2	28	2	12014504
Pubmed	An alternate targeting pathway for procathepsin L in mouse fibroblasts.	CTSL CTSV	6.25e-07	2	28	2	11929604
Pubmed	Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis.	CTSL CTSV	6.25e-07	2	28	2	20023699
Pubmed	Cathepsin L protects mice from mycoplasmal infection and is essential for airway lymphangiogenesis.	CTSL CTSV	6.25e-07	2	28	2	23600672
Pubmed	Mice that express enzymatically inactive cathepsin L exhibit abnormal spermatogenesis.	CTSL CTSV	6.25e-07	2	28	2	12533435
Pubmed	Impaired cathepsin L gene expression in skeletal muscle is associated with type 2 diabetes.	CTSL CTSV	6.25e-07	2	28	2	12941783
Pubmed	The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling.	CTSL CTSV	6.25e-07	2	28	2	12000732
Pubmed	Cathepsin L was involved in vascular aging by mediating phenotypic transformation of vascular cells.	CTSL CTSV	6.25e-07	2	28	2	36206719
Pubmed	Cathepsin-L influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number.	CTSL CTSV	6.25e-07	2	28	2	15905545
Pubmed	Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice.	CTSL CTSV	6.25e-07	2	28	2	12466121
Pubmed	Sequence and expression of the cDNA for MEP (major excreted protein), a transformation-regulated secreted cathepsin.	CTSL CTSV	6.25e-07	2	28	2	3689328
Pubmed	Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly.	CTSL CTSV	6.25e-07	2	28	2	10516062
Pubmed	Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling.	CTSL CTSV	6.25e-07	2	28	2	19096818
Pubmed	Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling.	CTSL CTSV	6.25e-07	2	28	2	11023992
Pubmed	Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease.	CTSL CTSV	6.25e-07	2	28	2	17671649
Pubmed	Close relationship of the major excreted protein of transformed murine fibroblasts to thiol-dependent cathepsins.	CTSL CTSV	6.25e-07	2	28	2	3755373
Pubmed	[Effect of bushen tiaojing recipe and xiaoyao pill on expression of cathepsin-L mRNA in gonadotropin-primed mice].	CTSL CTSV	6.25e-07	2	28	2	21434350
Pubmed	Alterations during positive selection in the thymus of nackt CD4-deficient mice.	CTSL CTSV	6.25e-07	2	28	2	11119260
Pubmed	Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts.	CTSL CTSV	6.25e-07	2	28	2	21972973
Pubmed	Cell type-specific functions of the lysosomal protease cathepsin L in the heart.	CTSL CTSV	6.25e-07	2	28	2	17942402
Pubmed	Cathepsin L stabilizes the histone modification landscape on the Y chromosome and pericentromeric heterochromatin.	CTSL CTSV	6.25e-07	2	28	2	16705169
Pubmed	Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels.	CTSL CTSV	6.25e-07	2	28	2	18469859
Pubmed	Cortical Thymocytes Along With Their Selecting Ligands Are Required for the Further Thymic Maturation of NKT Cells in Mice.	CTSL CTSV	6.25e-07	2	28	2	32457751
Pubmed	The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles.	CTSL CTSV	6.25e-07	2	28	2	15679121
Pubmed	Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts.	CTSL CTSV	6.25e-07	2	28	2	2835398
Pubmed	Cloning and expression of the gene for the major excreted protein of transformed mouse fibroblasts. A secreted lysosomal protease regulated by transformation.	CTSL CTSV	6.25e-07	2	28	2	2826441
Pubmed	Inhibition of cysteine protease cathepsin L increases the level and activity of lysosomal glucocerebrosidase.	CTSL CTSV	6.25e-07	2	28	2	38329128
Pubmed	Identification on melanoma cells of p39, a cysteine proteinase that cleaves C3, the third component of complement: amino-acid-sequence identities with procathepsin L.	CTSL CTSV	6.25e-07	2	28	2	8554545
Pubmed	Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies.	CTSL CTSV	6.25e-07	2	28	2	19589362
Pubmed	Cathepsin L is essential for onset of autoimmune diabetes in NOD mice.	CTSL CTSV	6.25e-07	2	28	2	16184198
Pubmed	The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling.	CTSL CTSV	6.25e-07	2	28	2	16079282
Interaction	CST3 interactions	CTSL CTSV CTSS	7.66e-06	29	27	3	int:CST3
Interaction	D2HGDH interactions	ARAP3 HERC1 RTEL1 SDHB	4.07e-05	146	27	4	int:D2HGDH
Cytoband	3p24.3	RFTN1 TBC1D5	1.25e-04	27	28	2	3p24.3
Cytoband	1p36.22	TARDBP C1orf167	2.36e-04	37	28	2	1p36.22
Cytoband	Ensembl 112 genes in cytogenetic band chr3p24	RFTN1 TBC1D5	2.18e-03	113	28	2	chr3p24
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	TARDBP C1orf167 SDHB	8.08e-03	681	28	3	chr1p36
GeneFamily	Cathepsins	CTSL CTSV CTSS	5.22e-07	15	20	3	470
GeneFamily	Sterile alpha motif domain containing	BFAR ARAP3	4.20e-03	88	20	2	760
GeneFamily	Actins\|Deafness associated genes	TRIOBP TECTA	6.84e-03	113	20	2	1152
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	TRIOBP ARAP3	2.15e-02	206	20	2	682
Coexpression	LIAN_NEUTROPHIL_GRANULE_CONSTITUENTS	CTSL CTSV CTSS	2.79e-06	26	28	3	MM639
Coexpression	LAKE_ADULT_KIDNEY_C21_COLLECTING_DUCT_INTERCALATED_CELLS_TYPE_B	KMT2C HERC1 RALGAPA2 TBC1D5	4.28e-06	103	28	4	M39240
Coexpression	NADLER_OBESITY_UP	CTSL CTSV CTSS	5.00e-05	67	28	3	MM1007
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUC19 KLF18 PLB1 TECTA	2.95e-06	160	28	4	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MUC19 KLF18 PLB1 TECTA	2.95e-06	160	28	4	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MUC19 KMT2C DACH2 CTSS	5.36e-06	186	28	4	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Pi16_(Pi16)\|Thalamus / BrainAtlas - Mouse McCarroll V32	TARDBP PLB1 ARAP3	9.52e-05	142	28	3	58bfff3284ae21150e4619511bd58622c16c5dde
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Pi16_(Pi16)--\|Thalamus / BrainAtlas - Mouse McCarroll V32	TARDBP PLB1 ARAP3	9.52e-05	142	28	3	5fd737c1fee9d97aee8955f1bf378ead3fce138d
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Pi16_(Pi16)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	TARDBP PLB1 ARAP3	9.52e-05	142	28	3	16f9945e835c3506b12d904778560d065a50f059
ToppCell	facs-Aorta-Heart-24m-Myeloid-nan\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLF18 BFAR CTSS	1.16e-04	152	28	3	525d65c5c8e5580947367afdb1f6e68b49e9e5bb
ToppCell	E16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NAGPA MYCBP2 CTSS	1.41e-04	162	28	3	9d6931619f5eb847c79d00ff5ae031fef30fd55c
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage_4\|356C / Donor, Lineage, Cell class and subclass (all cells)	PLB1 CTSL CTSS	1.73e-04	174	28	3	75b3a852140fb726025c3c987143d67944afde2d
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RFTN1 CTSL CTSS	1.89e-04	179	28	3	1757b9f3f4c634277a67c4f5a39d27d6b4937073
ToppCell	facs-Lung-Endomucin-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DACH2 RTEL1 CTSS	1.89e-04	179	28	3	de3245e1ee269e422de0308d0dd3623e4e9eb182
ToppCell	facs-Lung-Endomucin-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DACH2 RTEL1 CTSS	1.89e-04	179	28	3	c41c11171dfb40e5ddea6bf97d9373eb03a2321b
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RFTN1 CTSL CTSS	1.92e-04	180	28	3	64f01494a4052186773720e10b4e7c724ff94547
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-2\|TCGA-Skin / Sample_Type by Project: Shred V9	TDRD3 BFAR SDHB	1.95e-04	181	28	3	9d5b331cabc5524f0a9fd8b571e87be4c447c7d4
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RFTN1 CTSL CTSS	1.98e-04	182	28	3	33afbb7c4352b03266501b1f4f0e751c12c7350d
ToppCell	droplet-Marrow-nan-21m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RFTN1 CTSL CTSS	2.08e-04	185	28	3	65dcb0a7ee64990a34a87c167b44497107f035ee
ToppCell	LV-10._Endothelium_II\|World / Chamber and Cluster_Paper	ARAP3 TECTA RALGAPA2	2.14e-04	187	28	3	7876dcb4800c2e54874df3d933efb79307a64a97
ToppCell	(2)_5-FU-(1)_VE-Cad+_vascular_cells\|(2)_5-FU / Stress and Cell class	ARAP3 RALGAPA2 CTSL	2.21e-04	189	28	3	0f169b17bb26a812a5b0dcd6e29a3ca8415fd197
ToppCell	droplet-Marrow-nan-21m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNK12 NAGPA CTSS	2.25e-04	190	28	3	6c6d3259e23ec90c08756f500ae8a7aff8b8a5b3
ToppCell	(2)_5-FU-(1)_VE-Cad+_vascular_cells\|World / Stress and Cell class	ARAP3 RALGAPA2 CTSL	2.25e-04	190	28	3	6b391b8a3ffcbdec3acaf242bc52fc3fc9da77c8
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+-Alveolar_macrophage_CCL3+_L.1.0.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CTSL CTSS SDHB	2.35e-04	193	28	3	2653f83bc0289abdb4270c176ebdc24242600f9a
ToppCell	Control-Endothelial-Endothelial-Gen_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARAP3 RALGAPA2 DACH2	2.35e-04	193	28	3	e1d546165dcc2392f540162206852c4717d7306f
ToppCell	(4)_Endothelial_cells-(42)_EC-sinusoidal\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	ARAP3 RALGAPA2 CTSL	2.39e-04	194	28	3	4428b472c2042f88eae028b1770767512a515b75
ToppCell	LV-10._Endothelium_II\|LV / Chamber and Cluster_Paper	ARAP3 TECTA RALGAPA2	2.39e-04	194	28	3	b6cc849fa08599bff9839ef382d190cc964e273e
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	RFTN1 HERC1 MYCBP2	2.42e-04	195	28	3	4b9663509cc5e3f409f6d0d37640cb301a827d98
ToppCell	LA-09._Endothelium_I\|World / Chamber and Cluster_Paper	RFTN1 ARAP3 RALGAPA2	2.42e-04	195	28	3	fc95457a298b5d0dab687d9ee7e225a7f7b9a0d4
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMT2C HERC1 MYCBP2	2.42e-04	195	28	3	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	(1)_Control_(PBS)-(1)_VE-Cad+_vascular_cells\|World / Stress and Cell class	ARAP3 RALGAPA2 CTSL	2.42e-04	195	28	3	6b5d3ecec0c00ebfc889dc6235390ff53b5c0b6a
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMT2C HERC1 MYCBP2	2.42e-04	195	28	3	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	distal-Hematologic-Plasma-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KCNK12 TECTA GALR2	2.46e-04	196	28	3	8201aded3c7109fae5e6ca12bac2076acc7bf070
ToppCell	CV-Moderate-6\|CV / Virus stimulation, Condition and Cluster	RFTN1 KMT2C CTSS	2.46e-04	196	28	3	7bced0cc2112697593c478fa291b8ed3941fb811
ToppCell	remission-Non-classical_Monocyte\|remission / disease stage, cell group and cell class	PLB1 CTSL CTSS	2.46e-04	196	28	3	049d995986c20ce066bd64fcc2d2f1c2f8899883
ToppCell	distal-1-Hematologic-Plasma\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KCNK12 TECTA GALR2	2.50e-04	197	28	3	f5499bfa9dbc111f12563b7006bc45c2423ad0cd
ToppCell	wk_08-11-Hematologic-Myeloid-APOE+_Mac1\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CTSL CTSS SDHB	2.50e-04	197	28	3	121ec3f6d978de2f6c2cc397f7327d2e5587ab8b
ToppCell	remission-Non-classical_Monocyte\|World / disease stage, cell group and cell class	PLB1 CTSL CTSS	2.54e-04	198	28	3	1c170655070acca00520b7cf9c510a04c0a90a8f
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	KMT2C HERC1 TBC1D5	2.57e-04	199	28	3	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PLB1 CTSL CTSS	2.57e-04	199	28	3	df946601b295be5419c09befbfa73f4314eef116
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	KMT2C ARAP3 RALGAPA2	2.61e-04	200	28	3	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
Computational	Neighborhood of CDC16	TARDBP MYCBP2 SDHB	6.86e-05	75	12	3	MORF_CDC16
Computational	Neighborhood of PTPN11	TARDBP PPID SDHB	2.03e-04	108	12	3	MORF_PTPN11
Computational	Neighborhood of MAX	TARDBP MYCBP2	5.22e-04	31	12	2	GCM_MAX
Drug	Z-Phe-Phe-CHN2	CTSL CTSV CTSS	3.31e-06	24	28	3	CID005486921
Drug	cimaterol	CTSL CTSV CTSS	5.96e-06	29	28	3	CID000002755
Drug	Zfrn-mec	CTSL CTSV CTSS	6.61e-06	30	28	3	CID000125187
Drug	E64A	CTSL CTSV CTSS	7.32e-06	31	28	3	CID000173548
Drug	desmedipham	CTSL CTSV CTSS	7.32e-06	31	28	3	CID000024743
Drug	benzyloxycarbonyl-phenylalanylarginine-4-methylcoumaryl-7-amide	CTSL CTSS	8.74e-06	4	28	2	ctd:C021159
Drug	Zfa-fmk	CTSL CTSV CTSS	3.74e-05	53	28	3	CID000122019
Drug	dicyclohexyl phthalate	TARDBP RFTN1 ARAP3 CTSV GALR2 CTSS SDHB	5.29e-05	836	28	7	ctd:C036042
Drug	AC1NBIRU	CTSL CTSV CTSS	6.00e-05	62	28	3	CID004468718
Drug	glycolaldehyde	CTSL CTSS	6.52e-05	10	28	2	ctd:C010972
Drug	Chlorpromazine hydrochloride [69-09-0]; Down 200; 11.2uM; PC3; HT_HG-U133A	NAGPA RTEL1 CTSV TBC1D5	8.91e-05	194	28	4	1822_DN
Drug	AC1NR9X9	CTSL CTSS	9.55e-05	12	28	2	CID000657093
Drug	Neot	CTSL SDHB	9.55e-05	12	28	2	CID000410270
Drug	Etodolac [41340-25-4]; Down 200; 14uM; MCF7; HT_HG-U133A	TRIOBP RFTN1 TDRD3 NAGPA	9.65e-05	198	28	4	7006_DN
Drug	AC1NRA23	CTSL CTSV CTSS	9.78e-05	73	28	3	CID005287657
Drug	I-o-T	TECTA NAGPA	1.52e-04	15	28	2	CID000447122
Disease	otitis media (biomarker_via_orthology)	CTSL CTSV	1.17e-04	17	28	2	DOID:10754 (biomarker_via_orthology)
Disease	nephrotic syndrome (biomarker_via_orthology)	CTSL CTSV	2.37e-04	24	28	2	DOID:1184 (biomarker_via_orthology)
Disease	hyperthyroidism (biomarker_via_orthology)	CTSL CTSV	3.23e-04	28	28	2	DOID:7998 (biomarker_via_orthology)
Disease	muscular atrophy (biomarker_via_orthology)	CTSL CTSV	3.47e-04	29	28	2	DOID:767 (biomarker_via_orthology)
Disease	resting heart rate, chronic obstructive pulmonary disease	PLB1 HERC1	3.72e-04	30	28	2	EFO_0000341, EFO_0004351
Disease	pancreatitis (biomarker_via_orthology)	CTSL CTSV	6.30e-04	39	28	2	DOID:4989 (biomarker_via_orthology)
Disease	hepatocellular carcinoma (implicated_via_orthology)	CTSL CTSV	9.93e-04	49	28	2	DOID:684 (implicated_via_orthology)
Disease	Nonsyndromic Hearing Loss and Deafness, Autosomal Recessive	TRIOBP TECTA	1.08e-03	51	28	2	cv:CN043650
Disease	Nonsyndromic genetic hearing loss	TRIOBP TECTA	2.37e-03	76	28	2	cv:C5680182
Disease	dilated cardiomyopathy (implicated_via_orthology)	CTSL CTSV	2.62e-03	80	28	2	DOID:12930 (implicated_via_orthology)
Disease	Parkinson disease	MUC19 MYCBP2 TBC1D5	3.42e-03	321	28	3	MONDO_0005180
Disease	cerebral amyloid deposition measurement	MUC19 ARAP3	3.67e-03	95	28	2	EFO_0007707
Disease	hearing impairment	TRIOBP TECTA	3.90e-03	98	28	2	C1384666
Disease	brain ischemia (biomarker_via_orthology)	CTSL CTSV	4.22e-03	102	28	2	DOID:2316 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
GACGLGAVGQAQGQQ	C1orf167	756	Q5SNV9
AAGGGGTGLQEQQMS	ARAP3	901	Q8WWN8
RPQGNQGCNGGFMAR	CTSV	171	O60911
GGGGRGNTNTNECRM	DACH2	56	Q96NX9
MGNCVSGQQQEGGVS	RFTN1	491	Q14699
QTLGAQMQGGFGCGN	KMT2C	3821	Q8NEZ4
QMQGGFGCGNQLPKT	KMT2C	3826	Q8NEZ4
NNSMGQCGQGNSTGP	HERC1	691	Q15751
QNGFSGGVGALGIMN	KCNK12	406	Q9HB15
GQEGFGINEIGGNGM	MUC19	331	Q7Z5P9
CGFMGGLQRNGSTGQ	RALGAPA2	1691	Q2PPJ7
MNVSGCPGAGNASQA	GALR2	1	O43603
GGGGQNGQQAMSLAI	KCNA6	326	P17658
PNTGRANQQMGGGFF	BFAR	131	Q9NZS9
MGNGGRSGLQQGKGN	ARV1	1	Q9H2C2
GGQMTTSTGNQNLCG	KLF18	431	A0A0U1RQI7
GNKGCNGGFMTTAFQ	CTSS	176	P25774
MKGQGGAGGQFLSGQ	RTEL1	666	Q9NZ71
GGGGGGARSNLNMNA	TDRD3	151	Q9H7E2
NNQGSNMGGGMNFGA	TARDBP	301	Q13148
MIQGGDFSNQNGTGG	PPID	81	Q08752
QNGGFFRMNSGECLG	NAGPA	136	Q9UK23
GVNNKGQCGRDTGAM	MYCBP2	706	O75592
GQCGRDTGAMNQGGK	MYCBP2	711	O75592
QGQGGKCAMLAAQNN	PLB1	1261	Q6P1J6
FIASQGMGNGCGRSN	TRIOBP	2261	Q9H2D6
GPQGNEGCNGGLMDY	CTSL	171	P07711
GLGGVMAQAGFNGGN	TECTA	201	O75443
GQGRGQGQSVQMSGA	TBC1D5	681	Q92609
GICGSCAMNINGGNT	SDHB	96	P21912