Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR8I2 PDGFRB ADGRB3 OR5K4 PPARD PPARG OR52P1 PGR ADGRG6 OR11H6 OR8G1 OR51F2 OR4S1 OR52N5 OR8G5 OR5AP2	2.39e-05	884	109	16	GO:0004930
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF449 ZNF211 ZNF562 ZNF175 NSD1 ZBTB12 MYNN PPARD PPARG ZNF568 HNRNPU PGR ZNF248 ZNF71 ZNF419 ZNF836 ZNF716 ZNF547 EHMT2 ZNF735 ZNF844	3.59e-05	1459	109	21	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF449 ZNF211 ZNF562 ZNF175 NSD1 ZBTB12 MYNN PPARD PPARG ZNF568 HNRNPU PGR ZNF71 ZNF419 ZNF836 ZNF716 ZNF547 ZNF735 ZNF844	4.04e-05	1244	109	19	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF449 ZNF211 ZNF562 ZNF175 NSD1 ZBTB12 MYNN PPARD PPARG ZNF568 HNRNPU PGR ZNF71 ZNF419 ZNF836 ZNF716 ZNF547 ZNF735 ZNF844	5.41e-05	1271	109	19	GO:0000987
GeneOntologyMolecularFunction	olfactory receptor activity	OR8I2 OR5K4 OR52P1 OR11H6 OR8G1 OR51F2 OR4S1 OR52N5 OR8G5 OR5AP2	1.26e-04	431	109	10	GO:0004984
GeneOntologyMolecularFunction	proteoglycan binding	SLIT2 NF1 PTPRC CTSS	1.72e-04	51	109	4	GO:0043394
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF449 HIC1 ZNF211 ZNF562 ZNF175 ZBTB12 MYNN PPARD PPARG ZNF568 PGR ZNF248 ZNF71 ZNF419 ZNF836 ZNF716 ZNF547 ZNF735 ZNF844	2.15e-04	1412	109	19	GO:0000981
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR8I2 PDGFRB ADGRB3 OR5K4 PPARD PPARG OR52P1 CHRNB2 PGR ADGRG6 OR11H6 OR8G1 OR51F2 OR4S1 PTPRC OR52N5 OR8G5 OR5AP2	3.69e-04	1353	109	18	GO:0004888
GeneOntologyMolecularFunction	odorant binding	OR8I2 OR5K4 OR8G1 OR8G5 OR5AP2	6.63e-04	127	109	5	GO:0005549
GeneOntologyMolecularFunction	laminin binding	ADGRG6 SLIT2 CTSS	8.37e-04	34	109	3	GO:0043236
GeneOntologyMolecularFunction	transcription coregulator binding	PPARD PPARG ZNF568 PGR EHMT2	1.03e-03	140	109	5	GO:0001221
GeneOntologyBiologicalProcess	regulation of smooth muscle cell migration	PDGFRB PPARD PPARG PGR ARPC2 SLIT2 NF1	7.17e-06	134	109	7	GO:0014910
GeneOntologyBiologicalProcess	smooth muscle cell migration	PDGFRB PPARD PPARG PGR ARPC2 SLIT2 NF1	1.20e-05	145	109	7	GO:0014909
GeneOntologyBiologicalProcess	muscle cell migration	PDGFRB PPARD PPARG PGR ARPC2 SLIT2 NF1	2.37e-05	161	109	7	GO:0014812
Domain	zf-C2H2	ZNF449 HIC1 ZNF211 ZNF562 ZNF175 ZBTB12 MYNN DZIP1 ZNF688 ZNF568 ZNF248 ZNF71 ZNF419 ZNF836 ZNF716 ZNF547 ZNF735 ZNF844 ZNF687 ZNF222	2.55e-09	693	108	20	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF449 HIC1 ZNF211 ZNF562 ZNF175 ZBTB12 MYNN DZIP1 ZNF688 ZNF568 ZNF248 ZNF71 ZNF419 ZNF836 ZNF716 ZNF547 ZNF735 ZNF844 ZNF687 ZNF222	2.61e-09	694	108	20	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF449 HIC1 ZNF211 ZNF562 ZNF175 DZIP1L ZBTB12 MYNN DZIP1 ZNF688 ZNF568 ZNF248 ZNF71 ZNF419 ZNF836 ZNF716 ZNF547 ZNF735 ZNF844 ZNF687 ZNF222	2.95e-09	775	108	21	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF449 HIC1 ZNF211 ZNF562 ZNF175 DZIP1L ZBTB12 MYNN DZIP1 ZNF688 ZNF568 ZNF248 ZNF71 ZNF419 ZNF836 ZNF716 ZNF547 ZNF735 ZNF844 ZNF687 ZNF222	3.09e-09	777	108	21	PS00028
Domain	Znf_C2H2-like	ZNF449 HIC1 ZNF211 ZNF562 ZNF175 DZIP1L ZBTB12 MYNN DZIP1 ZNF688 ZNF568 ZNF248 ZNF71 ZNF419 ZNF836 ZNF716 ZNF547 ZNF735 ZNF844 ZNF687 ZNF222	4.73e-09	796	108	21	IPR015880
Domain	Znf_C2H2	ZNF449 HIC1 ZNF211 ZNF562 ZNF175 DZIP1L ZBTB12 MYNN DZIP1 ZNF688 ZNF568 ZNF248 ZNF71 ZNF419 ZNF836 ZNF716 ZNF547 ZNF735 ZNF844 ZNF687 ZNF222	5.77e-09	805	108	21	IPR007087
Domain	ZnF_C2H2	ZNF449 HIC1 ZNF211 ZNF562 ZNF175 DZIP1L ZBTB12 MYNN DZIP1 ZNF688 ZNF568 ZNF248 ZNF71 ZNF419 ZNF836 ZNF716 ZNF547 ZNF735 ZNF844 ZNF687 ZNF222	6.16e-09	808	108	21	SM00355
Domain	-	ZNF449 HIC1 ZNF211 ZNF562 ZNF175 ZBTB12 MYNN DZIP1 ZNF688 ZNF568 ZNF248 ZNF71 ZNF419 ZNF836 ZNF716 ZNF547 ZNF735 ZNF844 ZNF222	1.11e-08	679	108	19	3.30.160.60
Domain	KRAB	ZNF211 ZNF562 ZNF175 ZNF862 ZNF688 ZNF568 ZNF248 ZNF419 ZNF836 ZNF716 ZNF547 ZNF735 ZNF844 ZNF222	1.92e-08	358	108	14	PS50805
Domain	KRAB	ZNF211 ZNF562 ZNF175 ZNF862 ZNF688 ZNF568 ZNF248 ZNF419 ZNF836 ZNF716 ZNF547 ZNF735 ZNF844 ZNF222	1.92e-08	358	108	14	PF01352
Domain	KRAB	ZNF211 ZNF562 ZNF175 ZNF862 ZNF688 ZNF568 ZNF248 ZNF419 ZNF836 ZNF716 ZNF547 ZNF735 ZNF844 ZNF222	2.81e-08	369	108	14	SM00349
Domain	KRAB	ZNF211 ZNF562 ZNF175 ZNF862 ZNF688 ZNF568 ZNF248 ZNF419 ZNF836 ZNF716 ZNF547 ZNF735 ZNF844 ZNF222	2.91e-08	370	108	14	IPR001909
Domain	zf-C2H2_6	ZNF449 HIC1 ZNF211 ZNF562 MYNN ZNF568 ZNF71 ZNF419 ZNF836 ZNF735 ZNF844	2.06e-06	314	108	11	PF13912
Domain	Dzip-like_N	DZIP1L DZIP1	3.31e-05	2	108	2	PF13815
Domain	DZIP1_N	DZIP1L DZIP1	3.31e-05	2	108	2	IPR032714
Domain	1Cnucl_rcpt	PPARD PPARG	9.90e-05	3	108	2	IPR003074
Domain	Olfact_rcpt	OR8I2 OR5K4 OR11H6 OR8G1 OR51F2 OR4S1 OR52N5 OR8G5 OR5AP2	4.61e-04	393	108	9	IPR000725
Domain	GPS	PKD1L1 ADGRB3 ADGRG6	1.17e-03	36	108	3	PS50221
Domain	GPS	PKD1L1 ADGRB3 ADGRG6	1.27e-03	37	108	3	IPR000203
Domain	Laminin_G_1	SLIT2 EYS	1.76e-03	11	108	2	PF00054
Domain	zf-C4	PPARD PPARG PGR	2.38e-03	46	108	3	PF00105
Domain	Znf_hrmn_rcpt	PPARD PPARG PGR	2.38e-03	46	108	3	IPR001628
Domain	Nuclear_hrmn_rcpt	PPARD PPARG PGR	2.38e-03	46	108	3	IPR001723
Domain	NUCLEAR_REC_DBD_2	PPARD PPARG PGR	2.38e-03	46	108	3	PS51030
Domain	NUCLEAR_REC_DBD_1	PPARD PPARG PGR	2.38e-03	46	108	3	PS00031
Domain	ZnF_C4	PPARD PPARG PGR	2.38e-03	46	108	3	SM00399
Domain	-	PPARD PPARG PGR	2.53e-03	47	108	3	1.10.565.10
Domain	HOLI	PPARD PPARG PGR	2.69e-03	48	108	3	SM00430
Domain	Nucl_hrmn_rcpt_lig-bd	PPARD PPARG PGR	2.69e-03	48	108	3	IPR000536
Domain	Hormone_recep	PPARD PPARG PGR	2.69e-03	48	108	3	PF00104
Domain	Post-SET_dom	NSD1 EHMT2	3.77e-03	16	108	2	IPR003616
Domain	PostSET	NSD1 EHMT2	3.77e-03	16	108	2	SM00508
Domain	POST_SET	NSD1 EHMT2	3.77e-03	16	108	2	PS50868
Domain	-	PPARD PPARG PGR	4.39e-03	57	108	3	3.30.50.10
Domain	Znf_NHR/GATA	PPARD PPARG PGR	4.61e-03	58	108	3	IPR013088
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CACNA1E CTTNBP2 PPFIA1 SIPA1L3 ADGRB3 NSD1 RCOR2 HNRNPU ARPC2 CSNK1A1L NF1 EHMT2 CSNK1A1 RAPGEF2 MAPK8IP2 RAI1	5.68e-08	963	109	16	28671696
Pubmed	Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.	MED14 AGPS PGD HNRNPU ARPC2 VPS13D NF1 CTDP1 UTP20 SNRNP200 NBR1	2.02e-07	454	109	11	33226137
Pubmed	CK1α deficiency impairs mouse uterine adenogenesis by inducing epithelial cell apoptosis through GSK3β pathway and inhibiting Foxa2 expression through p53 pathway†.	PGR CSNK1A1L CSNK1A1	2.98e-07	5	109	3	37944068
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR8I2 OR5K4 OR52P1 OR11H6 OR8G1 OR51F2 OR52N5 OR8G5 OR5AP2	1.33e-06	340	109	9	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR8I2 OR5K4 OR52P1 OR11H6 OR8G1 OR51F2 OR52N5 OR8G5 OR5AP2	1.33e-06	340	109	9	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR8I2 OR5K4 OR52P1 OR11H6 OR8G1 OR51F2 OR52N5 OR8G5 OR5AP2	1.43e-06	343	109	9	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR8I2 OR5K4 OR52P1 OR11H6 OR8G1 OR51F2 OR52N5 OR8G5 OR5AP2	1.53e-06	346	109	9	14611657
Pubmed	Mechanisms of vascular dysfunction in mice with endothelium-specific deletion of the PPAR-δ gene.	PPARD PPARG	9.73e-06	2	109	2	24486511
Pubmed	The function of the nuclear receptor peroxisome proliferator-activated receptor delta in energy homeostasis.	PPARD PPARG	9.73e-06	2	109	2	14677574
Pubmed	Pleiotropic effects of peroxisome proliferator-activated receptor γ and δ in vascular diseases.	PPARD PPARG	9.73e-06	2	109	2	24107399
Pubmed	The Impact of PPARD and PPARG Polymorphisms on Glioma Risk and Prognosis.	PPARD PPARG	9.73e-06	2	109	2	32198386
Pubmed	The function of peroxisome proliferator-activated receptors PPAR-γ and PPAR-δ in Mycobacterium leprae-induced foam cell formation in host macrophages.	PPARD PPARG	9.73e-06	2	109	2	33075048
Pubmed	Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	23354688
Pubmed	Association of peroxisome proliferator-activated receptor α/δ/γ with obesity, and gene-gene interaction, in the Chinese Han population.	PPARD PPARG	9.73e-06	2	109	2	23545576
Pubmed	+294T/C polymorphism in the PPAR-delta gene is associated with risk of coronary artery disease in normolipidemic Tunisians.	PPARD PPARG	9.73e-06	2	109	2	20645257
Pubmed	PPARδ deficient mice develop elevated Th1/Th17 responses and prolonged experimental autoimmune encephalomyelitis.	PPARD PPARG	9.73e-06	2	109	2	21192919
Pubmed	Tissue-specific distribution of mouse casein kinase I alpha mRNA.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	9522121
Pubmed	Endothelial, but not smooth muscle, peroxisome proliferator-activated receptor β/δ regulates vascular permeability and anaphylaxis.	PPARD PPARG	9.73e-06	2	109	2	25556996
Pubmed	CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	37723657
Pubmed	Influence of tumor peroxisome proliferator-activated receptor gamma and delta expression on postoperative mortality of patients undergoing colorectal cancer surgery.	PPARD PPARG	9.73e-06	2	109	2	19283612
Pubmed	Cinnamaldehyde Contributes to Insulin Sensitivity by Activating PPARδ, PPARγ, and RXR.	PPARD PPARG	9.73e-06	2	109	2	26227398
Pubmed	Casein Kinase 1α Regulates Testosterone Synthesis and Testis Development in Adult Mice.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	36929849
Pubmed	CTLA-4 (+49A/G) and NOD2/CARD15 (N852S) polymorphisms with inflammatory bowel disease in Turkish patients.	NOD2 CTLA4	9.73e-06	2	109	2	30213296
Pubmed	Impact of peroxisome proliferator-activated receptors gamma and delta on adiposity in toddlers and preschoolers in the GENESIS Study.	PPARD PPARG	9.73e-06	2	109	2	18379566
Pubmed	PPARβ/δ activation protects against hepatic ischaemia-reperfusion injury.	PPARD PPARG	9.73e-06	2	109	2	37833850
Pubmed	Loss of hnRNPLL-dependent splicing of Ptprc has no impact on B-cell development, activation and terminal differentiation into antibody-secreting cells.	PTPRC HNRNPLL	9.73e-06	2	109	2	33331104
Pubmed	Peroxisome proliferator-activated receptor-γ and -δ polymorphisms in women with polycystic ovary syndrome.	PPARD PPARG	9.73e-06	2	109	2	20840271
Pubmed	Class III β-Tubulin Expression Is of Value in Selecting nab -Paclitaxel and Gemcitabine as First-Line Therapy in Unresectable Pancreatic Cancer.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	35695793
Pubmed	Cathepsin S promotes the development of pulmonary arterial hypertension.	PPARG CTSS	9.73e-06	2	109	2	31017016
Pubmed	Comparison of PPARδ and PPARγ in inhibiting the pro-inflammatory effects of C-reactive protein in endothelial cells.	PPARD PPARG	9.73e-06	2	109	2	19395102
Pubmed	PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages.	PPARD PPARG	9.73e-06	2	109	2	12740443
Pubmed	Exploring the role of casein kinase 1α splice variants across cancer cell lines.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	38852281
Pubmed	PPARbeta/delta potentiates PPARgamma-stimulated adipocyte differentiation.	PPARD PPARG	9.73e-06	2	109	2	15247146
Pubmed	Casein kinase 1 alpha regulates chromosome congression and separation during mouse oocyte meiotic maturation and early embryo development.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	23690993
Pubmed	Activation of PPARδ in bone marrow endothelial progenitor cells improves their hematopoiesis-supporting ability after myelosuppressive injury.	PPARD PPARG	9.73e-06	2	109	2	38704134
Pubmed	A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4.	PTPRC HNRNPLL	9.73e-06	2	109	2	18719244
Pubmed	The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis.	DZIP1L DZIP1	9.73e-06	2	109	2	19852954
Pubmed	The effects of kefir, koumiss, yogurt and commercial probiotic formulations on PPARα and PPAR-β/δ expressions in mouse kidney.	PPARD PPARG	9.73e-06	2	109	2	24205877
Pubmed	Knockdown of Csnk1a1 results in preimplantation developmental arrest in mice.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	36542875
Pubmed	Molecular evidence for the involvement of PPAR-δ and PPAR-γ in anti-inflammatory and neuroprotective activities of palmitoylethanolamide after spinal cord trauma.	PPARD PPARG	9.73e-06	2	109	2	23374874
Pubmed	Genomic organization of the mouse peroxisome proliferator-activated receptor beta/delta gene: alternative promoter usage and splicing yield transcripts exhibiting differential translational efficiency.	PPARD PPARG	9.73e-06	2	109	2	12059785
Pubmed	Peroxisome proliferator-activated receptor-β/δ, the acute signaling factor in prostacyclin-induced pulmonary vasodilation.	PPARD PPARG	9.73e-06	2	109	2	22021335
Pubmed	Deregulation of tumor angiogenesis and blockade of tumor growth in PPARbeta-deficient mice.	PPARD PPARG	9.73e-06	2	109	2	17641685
Pubmed	Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	25994086
Pubmed	Genetic polymorphisms of peroxisome proliferator-activated receptors and the risk of cardiovascular morbidity and mortality in a community-based cohort in washington county, Maryland.	PPARD PPARG	9.73e-06	2	109	2	18288282
Pubmed	Deficiency of PPARbeta/delta in the epidermis results in defective cutaneous permeability barrier homeostasis and increased inflammation.	PPARD PPARG	9.73e-06	2	109	2	17713572
Pubmed	The contrasting roles of PPARδ and PPARγ in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue.	PPARD PPARG	9.73e-06	2	109	2	21843327
Pubmed	Pro12Ala PPAR-γ2 and +294T/C PPAR-δ Polymorphisms and Association with Metabolic Traits in Teenagers from Northern Mexico.	PPARD PPARG	9.73e-06	2	109	2	32664384
Pubmed	Activation of PPARγ and δ by dietary punicic acid ameliorates intestinal inflammation in mice.	PPARD PPARG	9.73e-06	2	109	2	21736821
Pubmed	The effect of neuronal conditional knock-out of peroxisome proliferator-activated receptors in the MPTP mouse model of Parkinson's disease.	PPARD PPARG	9.73e-06	2	109	2	26028469
Pubmed	Peroxisome proliferator-activated receptor gamma is a target of progesterone regulation in the preovulatory follicles and controls ovulation in mice.	PPARG PGR	9.73e-06	2	109	2	18172011
Pubmed	PPARβ/δ activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells.	PPARD PPARG	9.73e-06	2	109	2	21070867
Pubmed	Nuclear receptors of the peroxisome proliferator-activated receptor (PPAR) family in gestational diabetes: from animal models to clinical trials.	PPARD PPARG	9.73e-06	2	109	2	20427759
Pubmed	Gene-gene interaction between PPARδ and PPARγ is associated with abdominal obesity in a Chinese population.	PPARD PPARG	9.73e-06	2	109	2	23273766
Pubmed	Csnk1a1 inhibition modulates the inflammatory secretome and enhances response to radiotherapy in glioma.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	34216174
Pubmed	Casein Kinase 1α as a Novel Factor Affects Thyrotropin Synthesis via PKC/ERK/CREB Signaling.	CSNK1A1L CSNK1A1	9.73e-06	2	109	2	37108197
Pubmed	Nuclear factor 1 synergizes with progesterone receptor on the mouse mammary tumor virus promoter wrapped around a histone H3/H4 tetramer by facilitating access to the central hormone-responsive elements.	PGR NF1	9.73e-06	2	109	2	19940123
Pubmed	Peroxisome-proliferator-activated receptors γ and β/δ mediate vascular endothelial growth factor production in colorectal tumor cells.	PPARD PPARG	9.73e-06	2	109	2	20221637
Pubmed	DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses.	DUOX2 NOD2	9.73e-06	2	109	2	19759286
Pubmed	Potentiation of colon cancer susceptibility in mice by colonic epithelial PPAR-δ/β overexpression.	PPARD PPARG	9.73e-06	2	109	2	24681603
Pubmed	Activation of PPARbeta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release.	PPARD PPARG	9.73e-06	2	109	2	19389799
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF175 MYNN ZNF836 ZNF844	1.73e-05	49	109	4	9630514
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	PPFIA1 INTS1 RNF213 NF1 CTDP1	1.98e-05	104	109	5	31240132
Pubmed	Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma.	PPARD PPARG	2.91e-05	3	109	2	9113987
Pubmed	Peroxisome Proliferator Activated Receptor Gamma Controls Mature Brown Adipocyte Inducibility through Glycerol Kinase.	PPARD PPARG	2.91e-05	3	109	2	29346772
Pubmed	A novel pathway involving progesterone receptor, 12/15-lipoxygenase-derived eicosanoids, and peroxisome proliferator-activated receptor gamma regulates implantation in mice.	PPARG PGR	2.91e-05	3	109	2	14688261
Pubmed	Changes in plasma PPARs levels in migraine patients.	PPARD PPARG	2.91e-05	3	109	2	25758678
Pubmed	Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization.	PDGFRB PPARG	2.91e-05	3	109	2	19801450
Pubmed	Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4.	PTPRC CTLA4	2.91e-05	3	109	2	27601670
Pubmed	Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL.	PTPRC HNRNPLL	2.91e-05	3	109	2	18669861
Pubmed	Association and interaction of PPARα, δ, and γ gene polymorphisms with low-density lipoprotein-cholesterol in a Chinese Han population.	PPARD PPARG	2.91e-05	3	109	2	26098621
Pubmed	CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation.	PTPRC CTLA4	2.91e-05	3	109	2	28644433
Pubmed	Roles of PPARs on regulating myocardial energy and lipid homeostasis.	PPARD PPARG	2.91e-05	3	109	2	17356846
Pubmed	Polymorphisms in PPARD, PPARG and APM1 associated with four types of traditional Chinese medicine constitutions.	PPARD PPARG	2.91e-05	3	109	2	20621019
Pubmed	Role of UCP2 in the protective effects of PPARβ/δ activation on lipopolysaccharide-induced endothelial dysfunction.	PPARD PPARG	2.91e-05	3	109	2	27179975
Pubmed	[Effects of PPARD-87T > C and interactions with single nucleotide polymorphisms in PPARA and PPARG on abdominal obesity].	PPARD PPARG	2.91e-05	3	109	2	22944052
Pubmed	Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.	CSNK1A1L CSNK1A1	2.91e-05	3	109	2	24616378
Pubmed	Effects of PPARalpha, gamma and delta haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study.	PPARD PPARG	2.91e-05	3	109	2	15128052
Pubmed	The CTLA4 variants may interact with the IL23R- and NOD2-conferred risk in development of Crohn's disease.	NOD2 CTLA4	2.91e-05	3	109	2	20537165
Pubmed	Peroxisome proliferator-activated receptor δ confers resistance to peroxisome proliferator-activated receptor γ-induced apoptosis in colorectal cancer cells.	PPARD PPARG	2.91e-05	3	109	2	21765467
Pubmed	The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review.	PPARD PPARG	2.91e-05	3	109	2	29762540
Pubmed	MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis.	MED14 PPARG	2.91e-05	3	109	2	20194623
Pubmed	Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity.	PPARD PPARG	2.91e-05	3	109	2	18657264
Pubmed	Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity.	PPARD PPARG	2.91e-05	3	109	2	18323470
Pubmed	Effects of PPARs/20-HETE on the renal impairment under diabetic conditions.	PPARD PPARG	2.91e-05	3	109	2	31163124
Pubmed	Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.	CSNK1A1L CSNK1A1	2.91e-05	3	109	2	25242043
Pubmed	Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.	CSNK1A1L CSNK1A1	2.91e-05	3	109	2	28655862
Pubmed	PPAR and GST polymorphisms may predict changes in intellectual functioning in medulloblastoma survivors.	PPARD PPARG	2.91e-05	3	109	2	30607709
Pubmed	PPAR nuclear receptors and altered RPE lipid metabolism in age-related macular degeneration.	PPARD PPARG	2.91e-05	3	109	2	20238044
Pubmed	De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity.	PDGFRB PPARG	2.91e-05	3	109	2	29497032
Pubmed	Peroxisome proliferator-activated receptors, orphans with ligands and functions.	PPARD PPARG	2.91e-05	3	109	2	9211064
Pubmed	Phospholipase A2-modified low-density lipoprotein activates macrophage peroxisome proliferator-activated receptors.	PPARD PPARG	2.91e-05	3	109	2	19948841
Pubmed	Expression of the peroxisome proliferator-activated receptors-alpha, -beta, and -gamma in ovarian carcinoma effusions is associated with poor chemoresponse and shorter survival.	PPARD PPARG	2.91e-05	3	109	2	19157507
Pubmed	Expression of peroxisome proliferator activated receptor mRNA in normal and tumorigenic rodent mammary glands.	PPARD PPARG	2.91e-05	3	109	2	9918810
Pubmed	Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.	PPARD PPARG	2.91e-05	3	109	2	8041794
Pubmed	Peroxisome proliferator-activated receptors are altered in pathologies of the human placenta: gestational diabetes mellitus, intrauterine growth restriction and preeclampsia.	PPARD PPARG	2.91e-05	3	109	2	20045185
Pubmed	Association between peroxisome proliferator-activated receptor-alpha, delta, and gamma polymorphisms and risk of coronary heart disease: A case-control study and meta-analysis.	PPARD PPARG	2.91e-05	3	109	2	27512842
Pubmed	Peroxisome proliferator-activated receptor {delta} is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart.	PPARD PPARG	2.91e-05	3	109	2	20075336
Pubmed	Modulating Intrafollicular Hormonal Milieu in Controlled Ovarian Stimulation: Insights From PPAR Expression in Human Granulosa Cells.	PPARD PPARG	2.91e-05	3	109	2	26332656
Pubmed	PPARβ/δ Agonism Upregulates Forkhead Box A2 to Reduce Inflammation in C2C12 Myoblasts and in Skeletal Muscle.	PPARD PPARG	2.91e-05	3	109	2	32143325
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF449 HIC1 ZNF211 ZNF562 ZNF175 ZNF862 ZBTB12 MYNN ZNF688 ZNF568 ZNF248 ZNF71 ZNF419 ZNF836 ZNF716 ZNF547 ZNF735 ZNF844 ZNF222	2.25e-10	718	80	19	28
GeneFamily	Nuclear hormone receptors	PPARD PPARG PGR	1.33e-03	49	80	3	71
GeneFamily	Olfactory receptors, family 8	OR8I2 OR8G1 OR8G5	1.33e-03	49	80	3	155
Coexpression	MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_12	RNF213 NF1 MLLT6	9.50e-06	11	103	3	M16845
ToppCell	LPS-IL1RA-Endothelial-Mes-Like-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PGR ZNF71 EYS SACS PDE5A PABPC1L	1.47e-06	145	108	6	90ca38c02325c5c637c32efdef634b54cc3cd105
ToppCell	PND07-28-samps-Myeloid\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	PPARG PGD ARPC2 PTPRC TALDO1 CTSS	3.46e-06	168	108	6	87512f9e5e95333e7ffc6efa1e93bab2ba9154c6
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDGFRB PGR ADGRG6 SLIT2 KCNJ8 PDE5A	5.84e-06	184	108	6	102b6f621a5b551e622f97b12d787c080b052a72
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDGFRB PGR ADGRG6 SLIT2 KCNJ8 PDE5A	5.84e-06	184	108	6	327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ZNF211 ZNF562 ZNF568 ZNF71 VPS13D CTLA4	6.60e-06	188	108	6	2c4e791df69a9df29922f9117e5cac7787c129ce
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ZNF211 ZNF562 ZNF568 ZNF71 VPS13D CTLA4	6.60e-06	188	108	6	b1ec7c45aedcc3d22cac898c6a3679e7f8b44c77
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HIC1 PDGFRB ADGRG6 KCNJ8 PDE5A RAPGEF2	6.81e-06	189	108	6	26cfe5b7e7f477f225f4e9f25f983f432f01e183
ToppCell	droplet-Limb_Muscle-nan-3m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIC1 PPARG ZNF568 CLK2 KCNJ8 PDE5A	6.81e-06	189	108	6	16a4c92dd7a0d60f3691bd3130a091a9a54730f1
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Myeloid\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PGD ARPC2 PTPRC MID1IP1 TALDO1 CTSS	8.87e-06	198	108	6	c4a004f211f72f28aacbb512c6e075cbd049be53
ToppCell	LPS_only-Hematopoietic_Myeloid\|LPS_only / Treatment groups by lineage, cell group, cell type	PGD ARPC2 PTPRC MID1IP1 TALDO1 CTSS	9.13e-06	199	108	6	20523dee39a4c5f6423259920f108127b47525c4
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	HIC1 PDGFRB DZIP1 ADGRG6 SLIT2 PDE5A	9.40e-06	200	108	6	786f1ae53e60b5ffbf4bfd393d10b802478148b3
ToppCell	Parenchyma_COVID-19-Immune-TX-TRAM-1\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	EML4 PPARG PGD PTPRC ZDHHC19 CTSS	9.40e-06	200	108	6	0a7addc5b2f3f3d91d93bf9d1a466c2acfbcc5de
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HIC1 CTTNBP2 ZNF175 MLLT6 PABPC1L	3.15e-05	149	108	5	a85a051e0d82430160967e72fa04b55f43e84513
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HIC1 CTTNBP2 ZNF175 MLLT6 PABPC1L	3.26e-05	150	108	5	7a381f5ae94eba5eb60dcbf83416b4eb18c279ea
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_2\|368C / Donor, Lineage, Cell class and subclass (all cells)	OTOA PPARG AFP TALDO1 CTSS	4.43e-05	160	108	5	ac3f56f8ab8efd11c4b4868a828db05c23ac762f
ToppCell	facs-Lung-Endomucin-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRB TRIM71 ADGRG6 SCN5A PDE5A	5.75e-05	169	108	5	2d23b4cee060f8adddc430c1c10d4e25205b4af6
ToppCell	facs-Lung-Endomucin-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRB TRIM71 ADGRG6 SCN5A PDE5A	5.75e-05	169	108	5	ecaf08e8e0b54d1c97a02bc1f65409fd43d68227
ToppCell	facs-Lung-Endomucin-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRB TRIM71 ADGRG6 SCN5A PDE5A	5.75e-05	169	108	5	ad6af6609acf158cb79e45ee7ca9af332be3c40c
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PDGFRB CHRNB2 ADGRG6 KCNJ8 PDE5A	5.91e-05	170	108	5	1f994b690e881106a5d54b3080ccce6260bc3ac5
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NOD2 PTPRC CTDP1 PDE5A ZDHHC19	6.08e-05	171	108	5	2b7c5a557c4bc5c573211c4d618bdd6766a24916
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NOD2 PTPRC CTDP1 PDE5A ZDHHC19	6.08e-05	171	108	5	dcb15bc54aeea06ef8f07f1134f3ff1e21ac0e4f
ToppCell	BAL-Mild-cDC_4\|Mild / Compartment, Disease Groups and Clusters	CTTNBP2 ZNF175 TRMU MLLT6 PABPC1L	7.54e-05	179	108	5	68511e87b12b8253de7771e5ccfc5869248b8450
ToppCell	droplet-Lung-1m-Hematologic-myeloid\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PGD ARPC2 PTPRC TALDO1 CTSS	7.54e-05	179	108	5	6d2458a887047b5c20389f08345ff5aac7c683e6
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-T_cells-Treg\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EML4 RNF213 PTPRC CTLA4 HNRNPLL	7.95e-05	181	108	5	a6c8b33a392de3df2f179317e329e45d3d8c6f52
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NOD2 PTPRC CTDP1 PDE5A ZDHHC19	8.16e-05	182	108	5	dc32f8f6a3b13918eb8e93c018f5823d86344080
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDGFRB PGR SLIT2 KCNJ8 PDE5A	8.37e-05	183	108	5	8a799807fbf24456a9811e0c64068187940a2f71
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDGFRB PGR ADGRG6 SLIT2 PDE5A	8.59e-05	184	108	5	689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCell	droplet-Lung-30m-Mesenchymal-myofibroblast\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PDGFRB DZIP1L ADGRG6 SCN5A PDE5A	8.59e-05	184	108	5	55dde9c4eebac2a33788c1ff1d8fe312d150fad4
ToppCell	droplet-Lung-30m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PDGFRB DZIP1L ADGRG6 SCN5A PDE5A	8.59e-05	184	108	5	7128a2be291544d3df3ed6c80f21ddda8437dcba
ToppCell	droplet-Lung-30m-Mesenchymal-myofibroblast-pericyte_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PDGFRB DZIP1L ADGRG6 SCN5A PDE5A	8.59e-05	184	108	5	d14238f7b0b55a4c8d7040bea854bd221a66ac30
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	PKD1L1 WDR25 CTLA4 NBR1 ZNF222	8.81e-05	185	108	5	e06a784a297f357f3f8e761c24fa70722048ab42
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Granulocytic-Neutrophil-Neu_c3-CST7\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CSNK1A1L PTPRC ZDHHC19 TALDO1 CTSS	8.81e-05	185	108	5	97f8a644f51c02a5f8a74d8c923ad637a15ed06d
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_1\|390C / Donor, Lineage, Cell class and subclass (all cells)	ZNF211 ZNF568 ZNF71 VPS13D CTLA4	9.04e-05	186	108	5	064b6047215597465bb51a8a1547ef5a226552f9
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PDGFRB ADGRB3 ADGRG6 SLIT2 PDE5A	9.27e-05	187	108	5	a9316e2818217ec5feae9cf8816f7249803caee6
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	EML4 RNF213 NF1 PTPRC RAPGEF2	9.50e-05	188	108	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HIC1 PDGFRB ADGRG6 KCNJ8 PDE5A	9.99e-05	190	108	5	2ab604d35456beba71c25511e0f819000e6642d2
ToppCell	E15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HIC1 PDGFRB ADGRG6 KCNJ8 PDE5A	9.99e-05	190	108	5	84fbd5664ec886120963d4f50dfa1fd1851d36c1
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neuron_precursor\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DBH RCOR2 ADGRG6 SCN5A MAPK8IP2	1.02e-04	191	108	5	a53616c84178eb6c29b48662358765b082df3f97
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor-Neuroblast\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADGRB3 DBH RCOR2 ADGRG6 SCN5A	1.02e-04	191	108	5	c7b95a5f9185d533c08754ce2e4ce91533eb612e
ToppCell	COVID-19-lung-Macrophage_PPARGhi_CD5Lhi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	EML4 PPARG PGD PTPRC CTSS	1.05e-04	192	108	5	bcfb9c005166bc0b4f8ee2dfc0c1540e8bf0e1ff
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HIC1 PDGFRB ADGRG6 KCNJ8 PDE5A	1.05e-04	192	108	5	430ef714bf2544d32f3fd96a55af010f79aa9be0
ToppCell	IPF-Stromal-Pericyte\|Stromal / Disease state, Lineage and Cell class	PDGFRB PPARG ADGRG6 KCNJ8 RAPGEF2	1.10e-04	194	108	5	3892b188f424ffb80f3c75a1b6709a21c1e1601d
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)\|Adult / Lineage, Cell type, age group and donor	EML4 PPARD PPARG PGD CTSS	1.13e-04	195	108	5	55e25f702af19146a161861cfd15f40bbda1dc35
ToppCell	PCW_07-8.5-Mesenchymal\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PDGFRB ADGRB3 DZIP1 SLIT2 PDE5A	1.16e-04	196	108	5	8e10802f52e5e1853ea4ad34bf9a32a34e6112b5
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CTTNBP2 PDGFRB ADGRB3 ADGRG6 SLIT2	1.18e-04	197	108	5	31a1852911bda38543916585fda34255fd62a134
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma-sinusoidal_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	HIC1 CTTNBP2 PPARG ADGRG6 KCNJ8	1.18e-04	197	108	5	4e58bbf3ecb30b4c8199adcc04d2eb134d90de56
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	EML4 RNF213 HNRNPU PTPRC SNRNP200	1.18e-04	197	108	5	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	PCW_13-14-Mesenchymal\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	PDGFRB ADGRB3 DZIP1 SLIT2 PDE5A	1.18e-04	197	108	5	73a2085d2682d636726a5432d572ae2a3fbe1c3f
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D231\|Adult / Lineage, Cell type, age group and donor	EML4 DZIP1L PPARD PPARG PTPRC	1.21e-04	198	108	5	79a415e19cedde13a88f5043d71557363f102322
ToppCell	ASK428-Immune\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	EML4 PPARG ARPC2 PTPRC CTSS	1.21e-04	198	108	5	777ee3e46943f8ec76ffc0f42be0e2658c0bd57f
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+-Alveolar_macrophage_CCL3+_L.1.0.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	OTOA SDSL PGD TALDO1 CTSS	1.21e-04	198	108	5	75e3600ade0f1fa763189672b2d936f5b04bb606
ToppCell	LPS_anti-TNF-Hematopoietic_Myeloid\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PGD ARPC2 PTPRC TALDO1 CTSS	1.21e-04	198	108	5	9aee419c59105d8a7ad83bc484b92d30a640666b
ToppCell	Adult-Immune\|Adult / Lineage, Cell type, age group and donor	EML4 PPARD PPARG PTPRC CTSS	1.21e-04	198	108	5	9bfd7b88aa646eaf5eddb15cf985c7ca910cb35e
ToppCell	distal-1-Hematologic\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PPARG PGD ARPC2 PTPRC CTSS	1.21e-04	198	108	5	a65f3dc81cb6be80bd92e2e5b54cb494fd8ce806
ToppCell	distal-Hematologic\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PPARG PGD ARPC2 PTPRC CTSS	1.21e-04	198	108	5	66360d51c19650332a4a982818b668233a7f080b
ToppCell	LPS_IL1RA-Hematopoietic_Myeloid\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PGD ARPC2 PTPRC MID1IP1 CTSS	1.24e-04	199	108	5	0e696f13c9bd135fbb31368d6dca29897d6a1a25
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Myeloid-Granulocytic_cells-Neutrophils\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PGD PTPRC MID1IP1 TALDO1 CTSS	1.24e-04	199	108	5	8c2ab13b5fffbab3da37041a7000d6537fc4db09
ToppCell	Control-Myeloid-TRAM1\|Myeloid / Condition, Lineage and Cell class	EML4 PPARG PGD TALDO1 CTSS	1.24e-04	199	108	5	664f5cab3fe5ab599d1944deed04857ae14a06d5
ToppCell	Control-Myeloid-TRAM1\|Control / Condition, Lineage and Cell class	EML4 PPARG PGD TALDO1 CTSS	1.24e-04	199	108	5	8785ea74b006df8d115885eaad429289c41e8d5b
ToppCell	VE-CD4-exh_CD4\|VE / Condition, Cell_class and T cell subcluster	EML4 RNF213 ARPC2 PTPRC CTLA4	1.24e-04	199	108	5	6b00a393ad06ae91bf135a54a53ad4de68956193
ToppCell	medial-2-Hematologic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PPARG PGD ARPC2 PTPRC CTSS	1.24e-04	199	108	5	37b24ec301c99a4383f0217bc92e911ae43f8162
ToppCell	PCW_10-12-Mesenchymal\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PDGFRB ADGRB3 DZIP1 SLIT2 PDE5A	1.24e-04	199	108	5	a09292de4c4447b8eee55d401808e43b817321cc
ToppCell	LPS_anti-TNF-Hematopoietic_Myeloid-Granulocytic_cells-Neutrophils\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PGD PTPRC MID1IP1 TALDO1 CTSS	1.24e-04	199	108	5	76aab03a51681f0ce3369887cf71a884b0998ec5
ToppCell	medial-Hematologic\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PPARG PGD ARPC2 PTPRC CTSS	1.24e-04	199	108	5	a8345d542098d3579dba0077ec1b5975cb87d0b7
ToppCell	Parenchyma_COVID-19-Immune-TX-TRAM-2\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	EML4 PPARG PGD PTPRC CTSS	1.24e-04	199	108	5	5e4f02cfb90912e83257ed20f69c12650d28619e
ToppCell	LPS_anti-TNF-Hematopoietic_Myeloid-Granulocytic_cells\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PGD PTPRC MID1IP1 TALDO1 CTSS	1.24e-04	199	108	5	7227e6be56e9f333ee143e1418d22de32a4ca66a
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Myeloid-Granulocytic_cells\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PGD PTPRC MID1IP1 TALDO1 CTSS	1.27e-04	200	108	5	1592ca96c59eb053d0f0915afb337db9f3a40c91
ToppCell	Lung_Parenchyma-Severe-Myeloid-TRAM-TRAM\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	EML4 PPARG PGD PTPRC CTSS	1.27e-04	200	108	5	196dd7a90f6f334496997af0375e7a2c86f9a197
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PDGFRB DZIP1 ADGRG6 SLIT2 PDE5A	1.27e-04	200	108	5	d2fcd3bd7c3223875f027eeb48ff621192a5f242
ToppCell	Lung_Parenchyma-Severe-Myeloid-TRAM-TRAM-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EML4 PPARG PGD PTPRC CTSS	1.27e-04	200	108	5	18f1415cfc718beffd91fb9f643cced2eefbca8d
ToppCell	Control_saline-Mesenchymal_myocytic\|Control_saline / Treatment groups by lineage, cell group, cell type	PDGFRB DZIP1 ADGRG6 SLIT2 PDE5A	1.27e-04	200	108	5	5ed4261157cd51109b314818133ac3a0d34ee5fa
ToppCell	Lung_Parenchyma-Severe-Myeloid-TRAM\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	EML4 PPARG PGD PTPRC CTSS	1.27e-04	200	108	5	5e6f965f7b1323f1309543f44335d519996dfc1e
ToppCell	Parenchyma_Control_(B.)-Immune-TX-TRAM-1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	EML4 PPARG PGD PTPRC CTSS	1.27e-04	200	108	5	b92804f15586e1802fdd931d6dfe742be8466944
ToppCell	Parenchyma_COVID-19-Immune-TX-MoAM-3\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	PPARG PGD PTPRC TALDO1 CTSS	1.27e-04	200	108	5	a0eb6e9e21930539b8939082c4097f6dfe8efa9b
ToppCell	Control-Myeloid\|Control / Condition, Lineage and Cell class	EML4 PPARG PGD TALDO1 CTSS	1.27e-04	200	108	5	379f5de322beb7f8f8a58c1609c8f895f8285132
ToppCell	LPS_IL1RA-Mesenchymal_myocytic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PDGFRB DZIP1 ADGRG6 SLIT2 PDE5A	1.27e-04	200	108	5	77631c471cc5d453a749784f838cfa6408caf09b
ToppCell	Tracheal-10x3prime_v2-Immune_Lymphocytic-T-T_CD8-MAIT\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ASTE1 PTPRC CTLA4 HNRNPLL	1.54e-04	111	108	4	58a1536cf63568ffc985baefa495af659dd9ba88
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sncg-Sncg_Slc17a8\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SDSL PLPPR1 GRXCR2 PDE5A	2.02e-04	119	108	4	6435891e6e33e7ae07e0c3a64a66edfbeedb54be
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|356C / Donor, Lineage, Cell class and subclass (all cells)	ASTE1 ZNF248 ZNF547 PTPRC	2.15e-04	121	108	4	4ec70ad316942d9ade7bbdbf0e117e7c52b59d90
Disease	Sudden infant death syndrome	CHRNB2 KCNJ8 SCN5A	7.88e-06	12	99	3	C0038644
Disease	syndromic X-linked intellectual disability Najm type (implicated_via_orthology)	CSNK1A1L CSNK1A1	2.31e-04	7	99	2	DOID:0060807 (implicated_via_orthology)
Disease	response to anti-thyroid drug, Drug-induced agranulocytosis	EHMT2 MOCOS	3.08e-04	8	99	2	EFO_0007838, HP_0012235
Disease	sciatic neuropathy (biomarker_via_orthology)	PDGFRB RCHY1 NF1 KCNJ8	3.52e-04	99	99	4	DOID:11446 (biomarker_via_orthology)
Disease	Tachycardia, Ventricular	KCNJ8 SCN5A	6.01e-04	11	99	2	C0042514
Disease	Intellectual Disability	CACNA1E PDGFRB NSD1 HNRNPU NF1 SACS RAI1	7.85e-04	447	99	7	C3714756
Disease	Graves ophthalmopathy (is_marker_for)	PPARG CTLA4	8.48e-04	13	99	2	DOID:0081120 (is_marker_for)
Disease	Brugada Syndrome 1	KCNJ8 SCN5A	8.48e-04	13	99	2	C4551804
Disease	Pheochromocytoma, Extra-Adrenal	DBH NF1	1.30e-03	16	99	2	C1257877
Disease	Moyamoya Disease	RNF213 NF1	1.47e-03	17	99	2	C0026654
Disease	phosphatidylcholine 40:6 measurement	NOD2 RAPGEF2	1.47e-03	17	99	2	EFO_0010389
Disease	graft-versus-host disease (is_implicated_in)	NOD2 CTLA4	1.47e-03	17	99	2	DOID:0081267 (is_implicated_in)
Disease	melanoma	PPARD PPARG NF1 CTLA4 RAI1	1.52e-03	248	99	5	C0025202
Disease	migraine disorder, systolic blood pressure	HIC1 RNF213	1.65e-03	18	99	2	EFO_0006335, MONDO_0005277
Disease	Pheochromocytoma	DBH NF1	1.84e-03	19	99	2	C0031511
Disease	cystatin C measurement	CCNI2 NSD1 NAPB PDE5A ALDOB CTSS	2.38e-03	402	99	6	EFO_0004617
Disease	hemoglobin measurement, mean corpuscular hemoglobin	PTPRC ZDHHC19	2.46e-03	22	99	2	EFO_0004509, EFO_0004527
Disease	Down syndrome (is_marker_for)	NAPB CTSS	2.46e-03	22	99	2	DOID:14250 (is_marker_for)
Disease	acute myeloid leukemia (is_implicated_in)	NSD1 NF1 CTLA4	2.87e-03	84	99	3	DOID:9119 (is_implicated_in)
Disease	drug-induced liver injury	OR5K4 PPARG	2.93e-03	24	99	2	EFO_0004228
Disease	Brugada Syndrome (disorder)	KCNJ8 SCN5A	2.93e-03	24	99	2	C1142166
Disease	smoking behavior, BMI-adjusted waist-hip ratio	NSD1 PPARG EHMT2	3.06e-03	86	99	3	EFO_0004318, EFO_0007788
Disease	systemic mastocytosis	CACNA1E EYS	3.18e-03	25	99	2	MONDO_0016586

Protein segments in the cluster

Peptide	Gene	Start	Entry
NKPCQLAFFRVDHSM	TBC1D12	616	O60347
CQQMSNKGIFHFQLG	CTDP1	201	Q9Y5B0
RQAFHVTCAQMAGLL	MLLT6	146	P55198
KLHRACFMNNSGILE	CACNA1E	246	Q15878
HSIMQLCNSKNAFVF	ADGRB3	106	O60242
RAMANCQAAKGQYVH	ALDOB	331	P05062
QVRHMAFQLCQAVKF	CLK2	266	P49760
QGLFIFIFHCAMKEN	ADGRG6	1106	Q86SQ4
HQAGMLKRNCFASVF	ARPC2	111	O15144
QHCMAGHQLLQFKGS	CCNI2	291	Q6ZMN8
NMNDHGFVVCAFNRT	PGD	21	P52209
AHRFHKACVSQLNGM	EHMT2	516	Q96KQ7
FSQECHKQAMQGFKL	CCDC142	511	Q17RM4
DAFCHHFSNMNKALL	ASTE1	201	Q2TB18
AFGFHGKCFQRIQQM	RCOR2	146	Q8IZ40
MQSFRERCGFHGKQQ	RAI1	1	Q7Z5J4
SFCKQHREGMLFISK	NSD1	2181	Q96L73
GLHQLKMNCSRVFNL	HNRNPLL	341	Q8WVV9
CDKTFMNATFLRGHI	DZIP1L	171	Q8IYY4
QMIKCSHLRGFQAGV	OTOA	366	Q7RTW8
AGRQKAFSTCASHLM	OR8I2	231	Q8N0Y5
ASVHTGCMFRVQFCK	OR8G1	156	Q15617
ASAHIGCMFRVQFCK	OR8G5	191	Q8NG78
HGQREMQSCFFSFIL	OR11H6	36	Q8NGC7
HAVIAVRNGKLCFMF	KCNJ8	196	Q15842
HRVQMFESNGSFLCK	TRIM71	816	Q2Q1W2
KHSLFNAMNRFIGAV	MID1IP1	11	Q9NPA3
LMVFHSSFINGKTCR	EYS	11	Q5T1H1
TKHEINFQAFCLGLM	INTS1	506	Q8N201
CHGSKFSMLANRFKE	GRXCR2	211	A6NFK2
MCFIGKRNFEHFLLQ	TRMU	221	O75648
CGGKFAQQRNLISHM	HIC1	596	Q14526
GGPEFQRCSHFFQMK	MAPK8IP2	741	Q13387
QRCSHFFQMKNISFC	MAPK8IP2	746	Q13387
FFQMKNISFCGCHPR	MAPK8IP2	751	Q13387
MRNASCHFRKVLNKG	DUOX2	346	Q9NRD8
INLNACIAQMFFLHG	OR51F2	106	Q8NH61
EHKIISFNGCMTQLF	OR4S1	86	Q8NGB4
RHAFNTAQCMFAALK	PDE5A	616	O76074
MKHINLSFAACGFLG	PNPLA4	1	P41247
AAAQRRKMCLFAGFQ	HNRNPU	586	Q00839
FLHRGNKELCRNMSN	VEPH1	136	Q14D04
HNKLFNKVFRCPMSF	ABCC11	896	Q96J66
GFAQKCQLVFHSRMH	MYNN	366	Q9NPC7
LKMVDSFHRNSFQCG	PPFIA1	1006	Q13136
SNEMVRKHFQAGHVC	MOCOS	436	Q96EN8
NFLMGTGRHCNKLFL	CSNK1A1L	141	Q8N752
AGHISASACLAQMFF	OR52P1	91	Q8NH57
KVMRDNSGHSRCFGF	PABPC1L	221	Q4VXU2
LMAENKAISFHGCAA	OR5AP2	91	Q8NGF4
AGEMCAFNKVLAHFV	MED14	631	O60244
SCKVFFKRAMEGQHN	PGR	586	P06401
ALCLKHRQMAAGFSC	CTTNBP2	1141	Q8WZ74
ISMHCNKSSAVRFQG	DBH	561	P09172
MACLGFQRHKAQLNL	CTLA4	1	P16410
RMARNKGNHCGIASF	CTSS	311	P25774
KAHDGSVFTLCQMRN	EML4	506	Q9HC35
LGTHFKLDNCTMFRF	SACS	2686	Q9NZJ4
FHALMKAGCIQLALN	SACS	3321	Q9NZJ4
VTNQFHRGLCRAFMD	PKD1L1	2586	Q8TDX9
QHACAVMKNFGTRTF	AFP	221	P02771
ANGMEFLASKNCVHR	PDGFRB	811	P09619
INFNACLAQMFFVHG	OR52N5	101	Q8NH56
RNMFHSCTGQAVKLI	UTP20	236	O75691
MFHVRKVCAANFGDI	PPP4R1	226	Q8TF05
QKCLALGMSHNAIRF	PPARD	131	Q03181
MAHLFEMGFCDRQLN	NBR1	921	Q14596
NFLMGIGRHCNKLFL	CSNK1A1	141	P48729
QKCLAVGMSHNAIRF	PPARG	196	P37231
LFMGNLRHKCVRNFT	SCN5A	271	Q14524
CQKSFAHFDVQSMLF	SIPA1L3	336	O60292
AVALFLGMCVVHNFK	PLPPR1	266	Q8TBJ4
CIRMTTGAFKAGNLH	OR5K4	141	A6NMS3
HFCDKAFMNQAFLQS	DZIP1	201	Q86YF9
SFKIRGIGHFCQEMA	SDSL	46	Q96GA7
HFPFDQQNCTMKFRS	CHRNB2	161	P17787
ASIRLMDNKQFQFGH	AGPS	416	O00116
LHCRECKNFNSMFAI	RAPGEF2	796	Q9Y4G8
EKHARFRQMCNSFFV	RNF213	4056	Q63HN8
EQFCLKTHMRAQNGG	ZNF562	136	Q6V9R5
GKSFCMFSHLNQHQI	ZNF735	191	P0CB33
HFIFMCPRCGKQFNH	ZBTB12	356	Q9Y330
IGLSMEFHGNCKRVF	XPO4	176	Q9C0E2
GKAFSQCSVFIIHMR	ZNF568	396	Q3ZCX4
HSMAKLLACRQNFLA	NOD2	861	Q9HC29
GKSFCMLSRLNQHQI	ZNF716	191	A6NP11
CGKSFSQRSNLMQHR	ZNF211	346	Q13398
CKQMDHFVGLNFNSN	NF1	2371	P21359
FSHGTMPLRNIFKNC	TECR	151	Q9NZ01
QKREFVCSGHQSFMA	SLIT2	251	O94813
AGNAFCQAAKLHMQL	NAPB	61	Q9H115
QCGKALSYLNFQRHM	ZNF844	341	Q08AG5
SKAHMFCVNALAARD	ZNF862	196	O60290
CGMRFKRKFAVEAHQ	ZNF688	216	P0C7X2
FTQGSHFMANKRCQL	SNRNP200	416	O75643
HFMANKRCQLPDGSF	SNRNP200	421	O75643
CGKFFMERSTLSRHQ	ZNF547	301	Q8IVP9
GFRHSNVVAFINEKM	TEX13A	11	Q9BXU3
FMEQQHLKEAGFCIQ	TTC7A	721	Q9ULT0
NNCIGHRNFRFFMLL	ZDHHC19	146	Q8WVZ1
QCRDKAGMAAHFQQL	ZNF687	681	Q8N1G0
GIHCNMTLLFSFAQA	TALDO1	161	P37837
NGRSTVQFHILGMKC	RCHY1	226	Q96PM5
HNIFLCGGFSSEMKA	WDR25	346	Q64LD2
CGKLFRDMSNLFIHQ	ZNF419	236	Q96HQ0
KVQRNGSAAMCHFTT	PTPRC	466	P08575
CGKAFSQRMNLTVHQ	ZNF71	191	Q9NQZ8
CSKSFRQRAGLIMHQ	ZNF449	496	Q6P9G9
GKSFCMNLRFGHQRA	ZNF248	276	Q8NDW4
FGRFSCLNKHQMIHS	ZNF836	871	Q6ZNA1
HDCGKAFFQMLSLFR	ZNF175	366	Q9Y473
CEKCGKAFMHNFQLQ	ZNF222	231	Q9UK12
NSFHINMRDTLGKCF	VPS13D	3476	Q5THJ4