Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

PRAMEF7 PRAMEF12 PPARG PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

4.25e-08551227GO:0042974
GeneOntologyMolecularFunctionubiquitin-like ligase-substrate adaptor activity

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

1.10e-05821226GO:1990756
GeneOntologyMolecularFunctionnuclear receptor binding

PRAMEF7 PRAMEF12 PPARG PRAMEF8 PRAMEF1 PRAMEF13 BAZ2A PRAMEF14

1.97e-051871228GO:0016922
GeneOntologyMolecularFunctionenzyme-substrate adaptor activity

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

2.56e-05951226GO:0140767
GeneOntologyMolecularFunctionRNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity

NANOGP8 NANOG

2.20e-0441222GO:0001010
GeneOntologyMolecularFunctionNADPH oxidase H202-forming activity

MICAL1 DUOX2

3.66e-0451222GO:0106294
GeneOntologyMolecularFunctionkainate selective glutamate receptor activity

GRIK1 GRIK2

5.47e-0461222GO:0015277
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

GRIK1 GRIK2 SLC9A4 SLC13A4 NALCN SLC38A7

6.44e-041711226GO:0015081
GeneOntologyMolecularFunctionextracellularly glutamate-gated ion channel activity

GRIK1 GRIK2

7.62e-0471222GO:0005234
GeneOntologyMolecularFunctionlysine-acetylated histone binding

NANOGP8 NANOG BAZ2A

8.01e-04301223GO:0070577
GeneOntologyMolecularFunctionacetylation-dependent protein binding

NANOGP8 NANOG BAZ2A

8.83e-04311223GO:0140033
GeneOntologyMolecularFunctioncoreceptor activity

LILRB3 ITGAV CSF2RB CSPG4

9.90e-04721224GO:0015026
GeneOntologyMolecularFunctionsignal recognition particle binding

DERL2 DERL3

1.01e-0381222GO:0005047
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

PRAMEF7 PRAMEF12 STING1 PPARG PRAMEF8 PRAMEF1 PRAMEF13 BAZ2A PRAMEF14

1.06e-034171229GO:0061629
GeneOntologyMolecularFunctionxenobiotic transmembrane transporter activity

SLC47A2 SLC29A4 ABCC10

1.16e-03341223GO:0042910
GeneOntologyBiologicalProcesssomatic stem cell population maintenance

PRAMEF7 NANOGP8 NANOG PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

2.55e-071081228GO:0035019
GeneOntologyBiologicalProcessblastocyst formation

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

6.86e-06781226GO:0001825
GeneOntologyBiologicalProcessnegative regulation of cell differentiation

MYCN PRAMEF7 RC3H2 LILRB3 NANOGP8 NANOG DAB1 PRAMEF12 PPARG DCC PRAMEF8 PRAMEF1 ITGAV PRAMEF13 JAK3 HOXB8 PRAMEF14

1.56e-0587512217GO:0045596
GeneOntologyBiologicalProcessoocyte development

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

2.71e-05991226GO:0048599
GeneOntologyBiologicalProcessoocyte differentiation

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

3.39e-051031226GO:0009994
GeneOntologyBiologicalProcessstem cell population maintenance

PRAMEF7 NANOGP8 NANOG PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

8.44e-052371228GO:0019827
GeneOntologyBiologicalProcessblastocyst development

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14 TTLL4

9.54e-051791227GO:0001824
GeneOntologyBiologicalProcessmaintenance of cell number

PRAMEF7 NANOGP8 NANOG PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

9.76e-052421228GO:0098727
GeneOntologyBiologicalProcessnegative regulation of developmental process

MYCN PRAMEF7 RC3H2 LILRB3 CLSTN3 NANOGP8 NANOG DAB1 PRAMEF12 PPARG DCC PRAMEF8 PRAMEF1 ITGAV PRAMEF13 JAK3 HOXB8 PRAMEF14 MDGA1

9.84e-05122012219GO:0051093
GeneOntologyCellularComponentCul2-RING ubiquitin ligase complex

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

3.24e-07471236GO:0031462
MousePhenoabnormal spermatogonia proliferation

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

7.20e-0747956MP:0002685
MousePhenoabnormal jejunum morphology

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13

8.05e-0641955MP:0004002
MousePhenoincreased circulating amylase level

PRAMEF7 VPS13C PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

1.61e-05119957MP:0008806
MousePhenoabnormal cecum morphology

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 SCMH1

5.66e-0599956MP:0000494
MousePhenoincreased kidney weight

PRAMEF7 CLSTN3 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

5.77e-05145957MP:0003917
MousePhenoabnormal duodenum morphology

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13

7.24e-0564955MP:0003271
MousePhenoabnormal circulating amylase level

PRAMEF7 VPS13C PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

9.15e-05156957MP:0008804
MousePhenoabnormal large intestine morphology

MYCN PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 ARAF JAK3 SCMH1

1.07e-04276959MP:0000489
MousePhenoenlarged urinary bladder

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 ZFYVE26

1.37e-04116956MP:0011874
DomainPRAME_family

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13

1.18e-07191225IPR026271
DomainDER1

DERL2 DERL3

1.26e-0431222IPR007599
DomainTECPR

TECPR2 HERC2

1.26e-0431222SM00706
DomainBeta-propeller_rpt_TECPR

TECPR2 HERC2

1.26e-0431222IPR006624
Pubmed

Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.

PRAMEF7 NANOGP8 NANOG PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

5.51e-1246126817287250
Pubmed

Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.

PRAMEF7 PRAMEF12 STING1 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

1.31e-1130126738786026
Pubmed

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

3.59e-1118126623894331
Pubmed

Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

3.59e-1118126612890732
Pubmed

Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

3.59e-1118126629731491
Pubmed

Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

3.59e-1118126614675769
Pubmed

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

5.23e-1119126628604677
Pubmed

Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

7.45e-1120126626694250
Pubmed

Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

7.45e-1120126616580637
Pubmed

Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

7.45e-1120126621425410
Pubmed

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

1.43e-1022126631729367
Pubmed

Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

1.92e-1023126619480014
Pubmed

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

3.36e-1025126612620990
Pubmed

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

3.36e-1025126637451217
Pubmed

Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

4.35e-1026126618500982
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

7.08e-1028126625089626
Pubmed

LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

1.68e-0932126637889087
Pubmed

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

2.99e-0935126619389355
Pubmed

Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13

3.44e-0917126523565261
Pubmed

Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13

3.44e-0917126537781892
Pubmed

Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13

4.75e-0918126539181896
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

2.80e-0850126631806660
Pubmed

An abundance of X-linked genes expressed in spermatogonia.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 USP26

7.72e-0859126611279525
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

PRAMEF7 ARHGAP10 MCAM PRAMEF12 PPARG DCC PRAMEF8 PRAMEF1 PRAMEF13 SCMH1 PRAMEF14

9.59e-083631261114691545
Pubmed

Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets.

ERVK-6 ERVV-2 ERVV-1

9.21e-076126323085571
Pubmed

ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13

2.26e-0658126531598710
Pubmed

AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness.

NANOGP8 NANOG ARAF

3.84e-069126330595535
Pubmed

Genetic Complexity of Crohn's Disease in Two Large Ashkenazi Jewish Families.

DUOX2 CSF2RB

1.30e-052126227373512
Pubmed

Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice.

GRIK1 GRIK2

1.30e-052126215673679
Pubmed

Stimulator of interferon genes promotes diabetic sarcopenia by targeting peroxisome proliferator activated receptors γ degradation and inhibiting fatty acid oxidation.

STING1 PPARG

1.30e-052126237735940
Pubmed

Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus.

GRIK1 GRIK2

1.30e-052126211182092
Pubmed

Modulation of excitatory synaptic transmission in the spinal substantia gelatinosa of mice deficient in the kainate receptor GluR5 and/or GluR6 subunit.

GRIK1 GRIK2

1.30e-052126214724198
Pubmed

The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neurones.

GRIK1 GRIK2

1.30e-052126215539395
Pubmed

RNA editing of human kainate receptor subunits.

GRIK1 GRIK2

1.30e-05212627696618
Pubmed

Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6.

GRIK1 GRIK2

1.30e-05212628260617
Pubmed

Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution.

ERVV-2 ERVV-1

1.30e-052126218826608
Pubmed

Functional evidence that the self-renewal gene NANOG regulates human tumor development.

NANOGP8 NANOG

1.30e-052126219415763
Pubmed

Assessing the role of GLUK5 and GLUK6 at hippocampal mossy fiber synapses.

GRIK1 GRIK2

1.30e-052126215537878
Pubmed

Characterization of LILRB3 and LILRA6 allelic variants in the Japanese population.

LILRB3 LILRA6

1.30e-052126233526815
Pubmed

Postnatal maturation of mossy fibre excitatory transmission in mouse CA3 pyramidal cells: a potential role for kainate receptors.

GRIK1 GRIK2

1.30e-052126215358807
Pubmed

Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis.

GRIK1 GRIK2

1.30e-052126224760837
Pubmed

Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation.

ERVV-2 ERVV-1

1.30e-052126223555306
Pubmed

ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling.

VPS13C STING1

1.30e-052126235657605
Pubmed

Identification of the kainate receptor subunits underlying modulation of excitatory synaptic transmission in the CA3 region of the hippocampus.

GRIK1 GRIK2

1.30e-052126211069933
Pubmed

Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation.

GRIK1 GRIK2

1.30e-052126212947409
Pubmed

Distinct frequency patterns of LILRB3 and LILRA6 allelic variants in Europeans.

LILRB3 LILRA6

1.30e-052126236449053
Pubmed

Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex.

GRIK1 GRIK2

1.30e-052126215928066
Pubmed

Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences.

GRIK1 GRIK2

1.30e-05212628700852
Pubmed

Q/R site editing controls kainate receptor inhibition by membrane fatty acids.

GRIK1 GRIK2

1.30e-052126216221857
Pubmed

Altered long-term synaptic plasticity and kainate-induced Ca2+ transients in the substantia gelatinosa neurons in GLU(K6)-deficient mice.

GRIK1 GRIK2

1.30e-052126216219388
Pubmed

Bitter receptor TAS2R138 facilitates lipid droplet degradation in neutrophils during Pseudomonas aeruginosa infection.

PPARG TAS2R38

1.30e-052126234083514
Pubmed

Subunit composition and alternative splicing regulate membrane delivery of kainate receptors.

GRIK1 GRIK2

1.30e-052126215014126
Pubmed

Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients.

LILRB3 LILRA6

1.30e-052126219617579
Pubmed

Subunit composition of kainate receptors in hippocampal interneurons.

GRIK1 GRIK2

1.30e-052126211144357
Pubmed

Nanog1 in NTERA-2 and recombinant NanogP8 from somatic cancer cells adopt multiple protein conformations and migrate at multiple M.W species.

NANOGP8 NANOG

1.30e-052126224598770
Pubmed

Contribution of aberrant GluK2-containing kainate receptors to chronic seizures in temporal lobe epilepsy.

GRIK1 GRIK2

1.30e-052126225043179
Pubmed

Differential expression of nanog1 and nanogp8 in colon cancer cells.

NANOGP8 NANOG

1.30e-052126222079639
Pubmed

DCC-Mediated Dab1 Phosphorylation Participates in the Multipolar-to-Bipolar Transition of Migrating Neurons.

DAB1 DCC

1.30e-052126229590626
Pubmed

MCAM knockdown impairs PPARγ expression and 3T3-L1 fibroblasts differentiation to adipocytes.

MCAM PPARG

1.30e-052126229468504
Pubmed

A mosaic of functional kainate receptors in hippocampal interneurons.

GRIK1 GRIK2

1.30e-052126215483117
Pubmed

Functional characterization of kainate receptors in the mouse nucleus accumbens.

GRIK1 GRIK2

1.30e-052126211985817
Pubmed

Diversity of the human LILRB3/A6 locus encoding a myeloid inhibitory and activating receptor pair.

LILRB3 LILRA6

1.30e-052126224096970
Pubmed

Expression of NANOG and NANOGP8 in a variety of undifferentiated and differentiated human cells.

NANOGP8 NANOG

1.30e-052126221136380
Pubmed

VPS13C and STING expression in neuropsychiatric systemic lupus erythematosus: unveiling an unbreached territory.

VPS13C STING1

1.30e-052126239306342
Pubmed

Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.

ARHGAP10 DAB1 STING1 TENM1 NLRP13

2.09e-0591126522610502
Pubmed

Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 TCL1B PER3 PRAMEF14

2.63e-05326126817015433
Pubmed

The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1.

NANOGP8 NANOG

3.90e-053126230814124
Pubmed

Multiple phases in regulation of Nanog expression during pre-implantation development.

NANOGP8 NANOG

3.90e-053126226660234
Pubmed

NG2/CSPG4, CD146/MCAM and VAP1/AOC3 are regulated by myocardin-related transcription factors in smooth muscle cells.

MCAM CSPG4

3.90e-053126233727640
Pubmed

Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog.

NANOGP8 NANOG

3.90e-053126218177668
Pubmed

Nanog co-regulated by Nodal/Smad2 and Oct4 is required for pluripotency in developing mouse epiblast.

NANOGP8 NANOG

3.90e-053126224929238
Pubmed

Nanog and transcriptional networks in embryonic stem cell pluripotency.

NANOGP8 NANOG

3.90e-053126217211451
Pubmed

The stem cell pluripotency factor NANOG activates transcription with two unusually potent subdomains at its C terminus.

NANOGP8 NANOG

3.90e-053126215502159
Pubmed

Nanog variability and pluripotency regulation of embryonic stem cells--insights from a mathematical model analysis.

NANOGP8 NANOG

3.90e-053126220574542
Pubmed

lincRNAs act in the circuitry controlling pluripotency and differentiation.

NANOGP8 NANOG

3.90e-053126221874018
Pubmed

Cell signalling regulates dynamics of Nanog distribution in embryonic stem cell populations.

NANOGP8 NANOG

3.90e-053126223054952
Pubmed

CrxOS maintains the self-renewal capacity of murine embryonic stem cells.

NANOGP8 NANOG

3.90e-053126219800316
Pubmed

Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog.

NANOGP8 NANOG

3.90e-053126226975336
Pubmed

Nanog suppresses cell migration by downregulating thymosin β4 and Rnd3.

NANOGP8 NANOG

3.90e-053126223329853
Pubmed

Distinct Subunit Domains Govern Synaptic Stability and Specificity of the Kainate Receptor.

GRIK1 GRIK2

3.90e-053126227346345
Pubmed

Cloning and functional expression of a cDNA encoding the mouse beta 2 subunit of the kainate-selective glutamate receptor channel.

GRIK1 GRIK2

3.90e-05312621379666
Pubmed

Effect of RNA editing and subunit co-assembly single-channel properties of recombinant kainate receptors.

GRIK1 GRIK2

3.90e-05312628730589
Pubmed

Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming.

NANOGP8 NANOG

3.90e-053126223665121
Pubmed

Ectopic overexpression of Nanog induces tumorigenesis in non-tumorous fibroblasts.

NANOGP8 NANOG

3.90e-053126226733157
Pubmed

Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features.

NANOGP8 NANOG

3.90e-053126216501172
Pubmed

Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells.

NANOGP8 NANOG

3.90e-053126219582141
Pubmed

Nanog is the gateway to the pluripotent ground state.

NANOGP8 NANOG

3.90e-053126219703398
Pubmed

Nanog Fluctuations in Embryonic Stem Cells Highlight the Problem of Measurement in Cell Biology.

NANOGP8 NANOG

3.90e-053126228636920
Pubmed

A distinct expression pattern in mammalian testes indicates a conserved role for NANOG in spermatogenesis.

NANOGP8 NANOG

3.90e-053126220539761
Pubmed

Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes.

NANOGP8 NANOG

3.90e-053126218584034
Pubmed

PPARγ Deficiency Suppresses the Release of IL-1β and IL-1α in Macrophages via a Type 1 IFN-Dependent Mechanism.

STING1 PPARG

3.90e-053126230143592
Pubmed

Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells.

NANOGP8 NANOG

3.90e-053126221969378
Pubmed

The phosphoinositide-3-kinase/Akt pathway mediates the transient increase in Nanog expression during differentiation of F9 cells.

NANOGP8 NANOG

3.90e-053126220661723
Pubmed

NANOG restores the impaired myogenic differentiation potential of skeletal myoblasts after multiple population doublings.

NANOGP8 NANOG

3.90e-053126229245050
Pubmed

Aggregation of embryonic stem cells induces Nanog repression and primitive endoderm differentiation.

NANOGP8 NANOG

3.90e-053126215494369
Pubmed

Identification of two distinct transactivation domains in the pluripotency sustaining factor nanog.

NANOGP8 NANOG

3.90e-053126214728807
Pubmed

Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions.

NANOGP8 NANOG

3.90e-053126221194951
Pubmed

Identification and regulation of a stage-specific stem cell niche enriched by Nanog-positive spermatogonial stem cells in the mouse testis.

NANOGP8 NANOG

3.90e-053126222388986
Pubmed

Nanog promotes transfer of pluripotency after cell fusion.

NANOGP8 NANOG

3.90e-053126216791199
Pubmed

The kainate receptor antagonist UBP310 but not single deletion of GluK1, GluK2, or GluK3 subunits, inhibits MPTP-induced degeneration in the mouse midbrain.

GRIK1 GRIK2

3.90e-053126231513786
InteractionPTK2B interactions

GIT1 ARHGAP10 MCAM BFAR STING1 JAK3 VAV1

6.43e-061191187int:PTK2B
Cytoband1p36.21

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

2.27e-086312661p36.21
Cytoband19q13.4

LILRB3 LILRA6 PTPRH KIR3DL2

6.93e-0579126419q13.4
Cytoband17q21.33

SPATA20 TMEM92 SLC35B1

1.99e-0441126317q21.33
Cytoband7p22.1

ERVK-6 TNRC18 SLC29A4

3.00e-044712637p22.1
CytobandEnsembl 112 genes in cytogenetic band chr1p36

PRAMEF7 PRAMEF12 HES3 PRAMEF8 PRAMEF1 PRAMEF13 PER3 PRAMEF14

6.10e-046811268chr1p36
GeneFamilyPRAME family

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

1.22e-0924866686
GeneFamilyGlutamate ionotropic receptor kainate type subunits

GRIK1 GRIK2

2.22e-0458621199
GeneFamilySolute carriers

SLC47A2 SLC9A4 SLC13A4 SLC16A5 SLC38A7 SLC29A4 SLC35B1 SLC23A3

5.81e-04395868752
GeneFamilyDolichyl D-mannosyl phosphate dependent mannosyltransferases|Phosphatidylinositol glycan anchor biosynthesis

POMT2 PIGM

7.88e-049862430
GeneFamilyRhomboid family

DERL2 DERL3

1.96e-0314862926
GeneFamilyADAM metallopeptidase domain containing|CD molecules

LILRB3 LILRA6 MCAM CR2 ITGAV CSF2RB KIR3DL2

2.72e-03394867471
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3_UNMETHYLATED

MYCN PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13

2.96e-07571246MM1262
CoexpressionKINNEY_DNMT1_METHYLATION_TARGETS

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13

5.45e-07341245MM955
CoexpressionKOHOUTEK_CCNT2_TARGETS

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

2.41e-06811246MM938
CoexpressionMIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED

MYCN PRAMEF7 LDHAL6B PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 JAK3 PLCE1

4.39e-062611249MM1277
CoexpressionMORI_SMALL_PRE_BII_LYMPHOCYTE_UP

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

7.32e-06981246MM592
CoexpressionHUANG_GATA2_TARGETS_DN

PRAMEF7 PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

7.32e-06981246MM942
CoexpressionINGRAM_SHH_TARGETS_UP

PRAMEF7 CP PRAMEF12 PRAMEF8 PRAMEF1 PRAMEF13 PRAMEF14

9.72e-061561247MM550
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

ARHGAP10 DAB1 GRIK1 GRIK2 DCC CSPG4 TENM1 CSMD1

9.99e-082001258f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

ARHGAP10 DAB1 GRIK1 GRIK2 DCC CSPG4 TENM1 CSMD1

9.99e-082001258cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

ARHGAP10 DAB1 GRIK1 GRIK2 DCC CSPG4 TENM1 CSMD1

9.99e-082001258c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

ARHGAP10 DAB1 GRIK1 GRIK2 DCC CSPG4 TENM1 CSMD1

9.99e-0820012584fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

ARHGAP10 DAB1 GRIK1 GRIK2 DCC CSPG4 TENM1 CSMD1

9.99e-082001258310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

ARHGAP10 DAB1 GRIK1 GRIK2 DCC CSPG4 TENM1 CSMD1

9.99e-082001258961858738ce35db8760c8c2e136f8369bc444ccf
ToppCellfacs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MYCN CLSTN3 C5orf22 TNRC18 NALCN CSMD1

5.46e-0615712561f21d78a467fe22c5ab75d0917b840c1ac93f32c
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HTR4 DAB1 ADAMTS13 DCC NALCN TNXB

1.39e-0518512566712512100ccef456d2e2bd201d0987986c92ac9
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARHGAP10 MCAM CSPG4 CSMD1 WDR17 PLCE1

1.44e-051861256a95744b8649096bd7cfc3591a02841fa411085b3
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DAB1 GRIK1 GRIK2 PPARG SLC29A4 PLCE1

1.72e-05192125667d6230e32d446dcb12047fae2c3f1faa80dd720
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

LRTM1 CP MSTO1 MAN1A2 DERL3 WDR17

2.10e-051991256121de4e02585de3a3010398387c523bacf8ce546
ToppCellMS-IIF-Lymphocyte-B-B_naive|IIF / Disease, condition lineage and cell class

ARHGAP24 CR2 CEPT1 TCL1B IGHD DERL3

2.16e-05200125615f429137b2a3906724118085fcd59750cd767c7
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)|Neuronal / cells hierarchy compared to all cells using T-Statistic

MCAM GRIK1 GRIK2 STON2 TENM1 PLCE1

2.16e-052001256107854f4855fc99c9f7e737eb246f0d868e6c5fd
Diseasemood instability measurement

HTR4 DCC RABGAP1L CSMD1 NUP160

1.43e-041281145EFO_0008475
DiseaseNEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE

ARHGAP24 NUP160 PLCE1

2.11e-04301143C1868672
Diseaseleukocyte immunoglobulin-like receptor subfamily B member 3 measurement

LILRB3 LILRA6

2.20e-0461142EFO_0802705
Diseaseleukocyte immunoglobulin-like receptor subfamily A member 6 measurement

LILRB3 LILRA6

2.20e-0461142EFO_0801767
Diseaseinterleukin 18 receptor accessory protein measurement

SLC9A4 TNXB

5.23e-0491142EFO_0008179
DiseaseHIV-1 infection

DAB1 USP26 TNXB OR2W6P

5.77e-04981144EFO_0000180
DiseaseSchizophrenia

HTR4 CP GRIK1 GRIK2 DCC CSF2RB STON2 CSMD1 MDGA1 TNXB SLC23A3

6.34e-0488311411C0036341
Diseaseleprosy

DAB1 EXT1 PPARG ALDH5A1

6.96e-041031144EFO_0001054
Diseasecolon cancer (implicated_via_orthology)

NANOGP8 NANOG

7.95e-04111142DOID:219 (implicated_via_orthology)
Diseaseesophageal squamous cell carcinoma

STING1 PLCE1

1.12e-03131142EFO_0005922
Diseaseglycodeoxycholate measurement

GRIK2 CSMD1

1.31e-03141142EFO_0010493
DiseasePsoriasis

CP PPARG CSMD1

1.41e-03571143C0033860
DiseasePustulosis of Palms and Soles

CP PPARG CSMD1

1.41e-03571143C0030246
Diseasetuberculosis

C5orf22 FRMPD4 DYNC2H1 NALCN CSMD1

1.54e-032161145MONDO_0018076
Diseaseresponse to vaccine, cytokine measurement

ARHGAP10 DAB1 TENM1 NLRP13

1.70e-031311144EFO_0004645, EFO_0004873
Diseaseamygdala volume change measurement

PKD1L1 CSMD1

1.71e-03161142EFO_0021490
Diseasecataract

CPAMD8 PKD1L1 HERC2 PLCE1

2.22e-031411144MONDO_0005129
Diseaselung cancer

GRIK1 CSMD1

2.96e-03211142MONDO_0008903
Diseaseglaucoma

GRIK2 HERC2 TMEM181 PLCE1

3.05e-031541144MONDO_0005041
Diseasetriacylglycerol 58:9 measurement

CSMD1 TNXB

3.25e-03221142EFO_0010443
DiseaseAutistic Disorder

TAF1C DAB1 CP GRIK2 EXT1

3.50e-032611145C0004352
Diseasefeeling miserable measurement

DCC RABGAP1L NUP160

3.59e-03791143EFO_0009598

Protein segments in the cluster

PeptideGeneStartEntry
QSFPWGKIPLNALTM

USP26

326

Q9BXU7
APNPDWASLNLGALM

AGAP3

646

Q96P47
VDLLPMPGPNANWTA

CLSTN3

316

Q9BQT9
GTEAPSIWLTGMNLP

CSMD1

266

Q96PZ7
SIWLTGMNLPSPVIS

CSMD1

271

Q96PZ7
GMNLPSPVISSKNWL

CSMD1

276

Q96PZ7
DQPPILTTNTGLQMW

CSPG4

1471

Q6UVK1
QPLLMTSWNIPTAEG

ADGRG4

1876

Q8IZF6
SPDPQALWFNISAQM

BAZ2A

1316

Q9UIF9
PRQLPAFQEGIMSWS

BAZ2A

1491

Q9UIF9
GVFSFLNPLSPDIWM

GRIK1

566

P39086
WPPTLLQMVHTLASN

GIT1

56

Q9Y2X7
SLLPMPLLSQAQWNE

ERVV-2

11

B6SEH9
LLTFQAPFLPWALMG

DERL3

146

Q96Q80
MQLFGPWGEIVSPSL

ADAMTS13

1301

Q76LX8
MPVQAAQWTEFLSCP

RC3H2

1

Q9HBD1
LLPQFRAPSWQTGMH

QSER1

21

Q2KHR3
PSFSALGPQLDMLWS

JAK3

1086

P52333
WSAPSNPLVIMVTGN

KIR3DL2

106

P43630
NLFPQTSLTLHMWPD

CP

676

P00450
CQSSPQLWGPMAIFL

MDGA1

936

Q8NFP4
IPGQTRSSMVQWLNP

ARHGAP10

676

A1A4S6
MLILPLNNFPWVING

ABCC10

546

Q5T3U5
PQTNCIIMSWTPPLN

DCC

736

P43146
PAFAFRSVPWLMTLN

LRTM1

66

Q9HBL6
GNPWLQMPTIADRSA

HSFY1

366

Q96LI6
MQAFTGCVPLLPWLA

NCDN

641

Q9UBB6
NNLPFTEPMLSVWAQ

HERC2

2271

O95714
LNLTGMIPADAPAQW

ENTPD8

446

Q5MY95
VPPSLAGIMQRTFAW

KIF12

126

Q96FN5
FPRDSQNPLLMWAAP

DUOX2

211

Q9NRD8
SLLPMPLLSQAQWNE

ERVV-1

11

B6SEH8
FCEPWTLNMQPAPLT

PER3

651

P56645
IPLNGTWLFTPVSKM

LDHAL6B

36

Q9BYZ2
MWPNITAAPFLLTGF

OR51B2

1

Q9Y5P1
TGSIPQMLYNLWGPD

OR2W6P

81

Q8NHA6
DSLMQFGGATPWTPL

MSTO1

386

Q9BUK6
MRSLQNSLQGLWPVP

HES3

46

Q5TGS1
LVNPTGNLPMWSNQT

NANOG

186

Q9H9S0
GWGLPVQSPQALVAM

MICAL1

851

Q8TDZ2
TWNGNFFPPQMTLLP

KCNRG

151

Q8N5I3
WSAPSDPLNILMAGQ

LILRA6

306

Q6PI73
WSAPSDPLNILMAGQ

LILRB3

306

O75022
TGMWNPNAPVFLALN

RABGAP1L

366

Q5R372
PTQLFPWMRPQAAAG

HOXB8

131

P17481
SAPPLLCQMTEGSWI

PRSS36

766

Q5K4E3
VQAWPFTCLPLGSLM

PRAMEF12

56

O95522
FQAMSQAVGLPPWLQ

OTULIN

136

Q96BN8
TLGNPTNVRNMSWLP

ARHGAP24

491

Q8N264
TDMLLSVPANPGISW

FCSK

151

Q8N0W3
SVSSVLPCFMGWIPQ

DYNC2H1

4241

Q8NCM8
QPLEQPSGSVLWMAA

ARAF

461

P10398
GPPFWQSMIPVLNIQ

CEPT1

231

Q9Y6K0
LFQNGSAELWPPGSM

CSF2RB

486

P32927
STQGLFVAMFWPLIP

BFAR

401

Q9NZS9
NMWGPTRLPTCVSVF

CR2

136

P20023
MGAVLPSFWGQQPLV

DAB1

336

O75553
VPVMLSNGWELPFSE

EXT1

356

Q16394
LLGPDWNCIPQMTTF

FRMPD4

546

Q14CM0
MSFPLSDQPVLGEWF

CPAMD8

191

Q8IZJ3
LVTTNVTWGIQPAPM

ITGAV

976

P06756
WASNPGMESLVPLVQ

C5orf22

326

Q49AR2
PPILGQTILTQWMMF

GLB1L

496

Q6UWU2
VSGFSPPNILLMWLE

IGHD

296

P01880
WVIPTFISFLPIMQG

HTR4

146

Q13639
SSNVPLPLLQGWVMF

MAL2

56

Q969L2
LVGTFPWMAPEVIQS

MAP3K20

166

Q9NYL2
NVAMPSWFDIIGLSP

LYPLA1

66

O75608
AFNTPTGIPWAMVNL

MAN1A2

301

O60476
QMPFSSLIGQTPRWH

DCLRE1A

126

Q6PJP8
LLNFQAPFLPWVLMG

DERL2

146

Q9GZP9
GVFSFLNPLSPDIWM

GRIK2

551

Q13002
AWMLGASQLSVPPLD

GPRIN2

186

O60269
VQAWPFTRLPLGSLM

PRAMEF8

56

Q5VWM4
NQMLSLSSLPPWAVT

SLC13A4

491

Q9UKG4
TQAPSSGLEGLMPQW

PKD1L1

2111

Q8TDX9
VQAWPFTCLPLGSLM

PRAMEF13

56

Q5VWM6
QLVNVAIFGPPWMAF

MCAM

421

P43121
WSVPPFLLFLVSSGM

TAS2R38

201

P59533
LWQVADLGSSLNMPP

USP9X

1021

Q93008
NAVGPPFTWMLALLG

STING1

111

Q86WV6
RLFPMTPNWFLNLSA

TMEM41A

161

Q96HV5
GVAAVITPWNFPSAM

ALDH5A1

196

P51649
LAQDPQSPMAGLRWL

POMT2

731

Q9UKY4
QDWGPFFSLAVPSML

SLC47A2

286

Q86VL8
AVPTPLPWNAMSLQI

LRRC15

46

Q8TF66
VQAWPFTCLPLGSLM

PRAMEF14

56

Q5SWL7
SSNPNPLMFWLHGIQ

PLCE1

1796

Q9P212
PVWTAPTFTHRQMLG

TAF1C

651

Q15572
LVNPTGNLPMWSNQT

NANOGP8

186

Q6NSW7
MPFWPTNFGISSVDL

PPARG

36

P37231
RSQPGMWPQSLSELV

SATL1

326

Q86VE3
MPTRPFFENIGSILW

SLC9A4

146

Q6AI14
PGNILTRPASWMAVF

SLC38A7

231

Q9NVC3
AQVMQTIPPGLFWRF

TENM1

406

Q9UKZ4
VQAWPFTCLPLGSLM

PRAMEF1

56

O95521
ALMWAKVNPFSPLGT

WDR17

1301

Q8IZU2
DWQMAPGRGLPNLLT

SPATA3

141

Q8NHX4
PLSQTGLNWPEMITA

NUP160

846

Q12769
ILFANPISPMQWVGT

SLC35B1

286

P78383
QTWMGSRLPLVQAPS

SLC23A3

101

Q6PIS1
QVALGSIWLMLPTPF

STON2

871

Q8WXE9
PLGFRLNASSWPMFL

SCMH1

126

Q96GD3
VQAWPFTRLPLGSLM

PRAMEF7

56

Q5VXH5
SPTPSNLPMVQLWAA

TNRC18

96

O15417
MSQAWVPGLAPTLLF

TMEM92

1

Q6UXU6
MWSVLGFPLPQVFLV

SLC16A5

246

O15375
TPNPVILQDCMWSGF

MYCN

106

P04198
PLSFLVNSWLPGMLD

TMEM181

366

Q9P2C4
MNVWLTPNLQPFVGG

SPATA20

166

Q8TB22
SWTPIAQNRGIMPFP

VAV1

116

P15498
LQAMWGQSLLPPVST

TNXB

4001

P22105
LLQQWGAEITMPAPS

ERVK-6

96

Q9Y6I0
ILSFELPMNLANWFP

SENP6

1046

Q9GZR1
WLQVDNQLPGAMFPV

VPS13C

3206

Q709C8
VGTQPLNPSLMLPAW

TECPR2

1241

O15040
GSLLVARTQPSPWQM

ATP6AP1

381

Q15904
SGQMPFSQLPAVWQL

TCL1B

76

O95988
PAWPCIFSLLMGISN

SLC29A4

446

Q7RTT9
ALWSTYGAMIPTQLP

TASOR2

36

Q5VWN6
QVLQPDMLPAQWTAG

ZSWIM1

406

Q9BR11
SFMWPNSTPVPLLQT

TTLL4

221

Q14679
WLLNPLPMAVSSRGN

PIGM

131

Q9H3S5
NASFMPGLWSPQEFI

PTPRH

876

Q9HD43
AMLALFSNPNPAEAW

ZFYVE26

306

Q68DK2
QLAAEPVPTGFFNMW

WDR41

356

Q9HAD4
QPMITSIPLNLWGQD

HERV-K104

81

P63124
AAIANWSELAPMPVG

KLHL32

321

Q96NJ5
LEPQQLMDFWSAPQG

NLRP13

36

Q86W25
WMPQNVPAESGAQLL

NALCN

971

Q8IZF0