Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor activity	LRP1 LRP2 LRP1B	1.14e-05	16	56	3	GO:0005041
GeneOntologyMolecularFunction	lipoprotein particle receptor activity	LRP1 LRP2 LRP1B	2.68e-05	21	56	3	GO:0030228
GeneOntologyMolecularFunction	fatty acyl-CoA hydrolase activity	ACOT1 ACOT6 ACOT2	5.83e-05	27	56	3	GO:0047617
GeneOntologyMolecularFunction	acyl-CoA hydrolase activity	ACOT1 ACOT6 ACOT2	6.51e-05	28	56	3	GO:0016289
GeneOntologyMolecularFunction	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5B KDM5D	1.15e-04	6	56	2	GO:0034647
GeneOntologyMolecularFunction	histone H3K4 demethylase activity	KDM5B KDM5D	2.14e-04	8	56	2	GO:0032453
GeneOntologyMolecularFunction	protein transporter activity	TIMM17B LRP2 TIMM17A	2.22e-04	42	56	3	GO:0140318
GeneOntologyMolecularFunction	thiolester hydrolase activity	ACOT1 ACOT6 ACOT2	3.10e-04	47	56	3	GO:0016790
GeneOntologyMolecularFunction	carboxylic ester hydrolase activity	ACOT1 ACOT6 ACOT2 OC90	9.83e-04	157	56	4	GO:0052689
GeneOntologyMolecularFunction	long-chain fatty acyl-CoA hydrolase activity	ACOT1 ACOT2	1.02e-03	17	56	2	GO:0052816
GeneOntologyMolecularFunction	extracellular matrix binding	ADAMTSL5 FKRP CHADL	1.13e-03	73	56	3	GO:0050840
GeneOntologyMolecularFunction	cargo receptor activity	LRP1 LRP2 LRP1B	1.75e-03	85	56	3	GO:0038024
GeneOntologyMolecularFunction	extracellular matrix structural constituent	VWF CHADL ZP4 SSPOP	1.91e-03	188	56	4	GO:0005201
GeneOntologyMolecularFunction	protein transmembrane transporter activity	TIMM17B TIMM17A	2.79e-03	28	56	2	GO:0008320
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM5B KDM5D	2.79e-03	28	56	2	GO:0141052
GeneOntologyMolecularFunction	histone demethylase activity	KDM5B KDM5D	3.41e-03	31	56	2	GO:0032452
GeneOntologyMolecularFunction	protein demethylase activity	KDM5B KDM5D	3.63e-03	32	56	2	GO:0140457
GeneOntologyMolecularFunction	macromolecule transmembrane transporter activity	TIMM17B TIMM17A	4.09e-03	34	56	2	GO:0022884
GeneOntologyMolecularFunction	calcium ion binding	LRP1 LRP2 VWCE LRP1B SVEP1 NOTCH3 OC90	4.77e-03	749	56	7	GO:0005509
GeneOntologyBiologicalProcess	long-chain fatty-acyl-CoA catabolic process	ACOT1 ACOT2	2.17e-05	3	56	2	GO:0036116
GeneOntologyBiologicalProcess	positive regulation of lysosomal protein catabolic process	LRP1 LRP2	7.20e-05	5	56	2	GO:1905167
GeneOntologyBiologicalProcess	chemoattraction of axon	LRP1 LRP2	7.20e-05	5	56	2	GO:0061642
GeneOntologyBiologicalProcess	artery morphogenesis	LRP1 LRP2 CHD7 NOTCH3	1.14e-04	92	56	4	GO:0048844
GeneOntologyBiologicalProcess	positive regulation of protein catabolic process in the vacuole	LRP1 LRP2	1.51e-04	7	56	2	GO:1904352
GeneOntologyBiologicalProcess	fatty-acyl-CoA catabolic process	ACOT1 ACOT2	2.01e-04	8	56	2	GO:0036115
GeneOntologyBiologicalProcess	convergent extension involved in axis elongation	VANGL2 SFRP1	2.01e-04	8	56	2	GO:0060028
GeneOntologyCellularComponent	extracellular matrix	CCN5 SFRP1 FCGBP VWF ADAMTSL5 CHADL ZP4 SSPOP SVEP1 OC90	9.86e-06	656	57	10	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	CCN5 SFRP1 FCGBP VWF ADAMTSL5 CHADL ZP4 SSPOP SVEP1 OC90	1.01e-05	658	57	10	GO:0030312
GeneOntologyCellularComponent	cell surface	MPL CCN5 SFRP1 VWF EPPIN CLEC17A LRP1 LRP2 CHADL NOTCH3	7.61e-04	1111	57	10	GO:0009986
GeneOntologyCellularComponent	TIM23 mitochondrial import inner membrane translocase complex	TIMM17B TIMM17A	8.55e-04	16	57	2	GO:0005744
HumanPheno	Prolonged bleeding time	MPL VWF HPS6 GP1BB	2.27e-05	50	18	4	HP:0003010
MousePheno	abnormal circulating mineral level	VANGL2 TIMM17B PTPDC1 SFRP1 TBC1D12 LRP2 ADCK2 ZFYVE26 CHD7 NDUFA8 LRP1B SVEP1	2.08e-05	982	42	12	MP:0006357
MousePheno	abnormal mineral level	VANGL2 TIMM17B PTPDC1 SFRP1 TBC1D12 LRP2 ADCK2 ZFYVE26 CHD7 NDUFA8 LRP1B SVEP1	4.69e-05	1066	42	12	MP:0000192
MousePheno	abnormal mineral homeostasis	VANGL2 TIMM17B PTPDC1 SFRP1 TBC1D12 LRP2 ADCK2 ZFYVE26 CHD7 NDUFA8 LRP1B SVEP1	5.14e-05	1076	42	12	MP:0005636
MousePheno	abnormal lateral ventricle morphology	VANGL2 FKRP LRP2 CHD7 SSPOP	1.25e-04	164	42	5	MP:0000823
Domain	TIL_dom	FCGBP VWF LRP2 SSPOP	7.09e-08	14	56	4	IPR002919
Domain	VWC	CCN5 FCGBP VWF VWCE SSPOP	9.40e-08	38	56	5	SM00214
Domain	LDLR_class-A_CS	LRP1 LRP2 MFRP LRP1B SSPOP	1.23e-07	40	56	5	IPR023415
Domain	VWF_dom	CCN5 FCGBP VWF VWCE SSPOP	1.58e-07	42	56	5	IPR001007
Domain	EGF_CA	LRP1 LRP2 VWCE LRP1B SVEP1 NOTCH3	2.16e-07	86	56	6	PF07645
Domain	Ldl_recept_a	LRP1 LRP2 MFRP LRP1B SSPOP	2.25e-07	45	56	5	PF00057
Domain	-	LRP1 LRP2 MFRP LRP1B SSPOP	2.52e-07	46	56	5	4.10.400.10
Domain	BAAT_C	ACOT1 ACOT6 ACOT2	2.54e-07	5	56	3	IPR014940
Domain	BAAT_C	ACOT1 ACOT6 ACOT2	2.54e-07	5	56	3	PF08840
Domain	VWC_out	FCGBP VWF VWCE SSPOP	2.72e-07	19	56	4	SM00215
Domain	LDLRA_1	LRP1 LRP2 MFRP LRP1B SSPOP	3.13e-07	48	56	5	PS01209
Domain	LDLRA_2	LRP1 LRP2 MFRP LRP1B SSPOP	3.48e-07	49	56	5	PS50068
Domain	LDrepeatLR_classA_rpt	LRP1 LRP2 MFRP LRP1B SSPOP	3.48e-07	49	56	5	IPR002172
Domain	LDLa	LRP1 LRP2 MFRP LRP1B SSPOP	3.48e-07	49	56	5	SM00192
Domain	Growth_fac_rcpt_	CCN5 LRP1 LRP2 VWCE LRP1B SVEP1 NOTCH3	4.08e-07	156	56	7	IPR009030
Domain	EGF_Ca-bd_CS	LRP1 LRP2 VWCE LRP1B SVEP1 NOTCH3	4.42e-07	97	56	6	IPR018097
Domain	EGF_3	LRP1 LRP2 NRG3 VWCE LRP1B SSPOP SVEP1 NOTCH3	4.71e-07	235	56	8	PS50026
Domain	EGF	FCGBP LRP1 LRP2 NRG3 VWCE LRP1B SVEP1 NOTCH3	4.71e-07	235	56	8	SM00181
Domain	EGF_CA	LRP1 LRP2 VWCE LRP1B SVEP1 NOTCH3	4.99e-07	99	56	6	PS01187
Domain	ASX_HYDROXYL	LRP1 LRP2 VWCE LRP1B SVEP1 NOTCH3	5.29e-07	100	56	6	PS00010
Domain	EGF-like_dom	FCGBP LRP1 LRP2 NRG3 VWCE LRP1B SVEP1 NOTCH3	7.29e-07	249	56	8	IPR000742
Domain	EGF-type_Asp/Asn_hydroxyl_site	LRP1 LRP2 VWCE LRP1B SVEP1 NOTCH3	7.47e-07	106	56	6	IPR000152
Domain	EGF_1	LRP1 LRP2 NRG3 VWCE LRP1B SSPOP SVEP1 NOTCH3	8.73e-07	255	56	8	PS00022
Domain	EGF_2	LRP1 LRP2 NRG3 VWCE LRP1B SSPOP SVEP1 NOTCH3	1.16e-06	265	56	8	PS01186
Domain	EGF_CA	LRP1 LRP2 VWCE LRP1B SVEP1 NOTCH3	1.71e-06	122	56	6	SM00179
Domain	EGF-like_Ca-bd_dom	LRP1 LRP2 VWCE LRP1B SVEP1 NOTCH3	1.88e-06	124	56	6	IPR001881
Domain	EGF	LRP1 LRP2 NRG3 LRP1B SVEP1 NOTCH3	2.06e-06	126	56	6	PF00008
Domain	VWFC_1	CCN5 VWF VWCE SSPOP	3.97e-06	36	56	4	PS01208
Domain	VWFC_2	CCN5 VWF VWCE SSPOP	4.96e-06	38	56	4	PS50184
Domain	TIL	FCGBP VWF SSPOP	5.51e-06	12	56	3	PF01826
Domain	C8	FCGBP VWF SSPOP	5.51e-06	12	56	3	PF08742
Domain	Unchr_dom_Cys-rich	FCGBP VWF SSPOP	7.15e-06	13	56	3	IPR014853
Domain	C8	FCGBP VWF SSPOP	7.15e-06	13	56	3	SM00832
Domain	DUF5050	LRP1 LRP1B	8.83e-06	2	56	2	IPR032485
Domain	Tim17	TIMM17B TIMM17A	8.83e-06	2	56	2	IPR005678
Domain	DUF5050	LRP1 LRP1B	8.83e-06	2	56	2	PF16472
Domain	Ldl_recept_b	LRP1 LRP2 LRP1B	9.08e-06	14	56	3	PF00058
Domain	LDLRB	LRP1 LRP2 LRP1B	9.08e-06	14	56	3	PS51120
Domain	LY	LRP1 LRP2 LRP1B	1.13e-05	15	56	3	SM00135
Domain	LDLR_classB_rpt	LRP1 LRP2 LRP1B	1.13e-05	15	56	3	IPR000033
Domain	EGF-like_CS	LRP1 LRP2 NRG3 VWCE LRP1B SVEP1 NOTCH3	1.24e-05	261	56	7	IPR013032
Domain	VWD	FCGBP VWF SSPOP	1.39e-05	16	56	3	SM00216
Domain	VWF_type-D	FCGBP VWF SSPOP	1.39e-05	16	56	3	IPR001846
Domain	VWFD	FCGBP VWF SSPOP	1.39e-05	16	56	3	PS51233
Domain	VWD	FCGBP VWF SSPOP	1.39e-05	16	56	3	PF00094
Domain	EGF_extracell	LRP2 LRP1B SVEP1 NOTCH3	3.12e-05	60	56	4	IPR013111
Domain	EGF_2	LRP2 LRP1B SVEP1 NOTCH3	3.12e-05	60	56	4	PF07974
Domain	Lys_sp_deMease-like_dom	KDM5B KDM5D	5.28e-05	4	56	2	IPR013637
Domain	PLU-1	KDM5B KDM5D	5.28e-05	4	56	2	PF08429
Domain	Bile_Hydr_Trans	ACOT1 ACOT2	5.28e-05	4	56	2	PF04775
Domain	Thio_Ohase/aa_AcTrfase	ACOT1 ACOT2	5.28e-05	4	56	2	IPR006862
Domain	Acyl-CoA_thioEstase_long-chain	ACOT1 ACOT2	5.28e-05	4	56	2	IPR016662
Domain	cEGF	LRP1 LRP2 LRP1B	6.32e-05	26	56	3	IPR026823
Domain	cEGF	LRP1 LRP2 LRP1B	6.32e-05	26	56	3	PF12662
Domain	Znf_FYVE_PHD	KDM5B ZFYVE21 PHF7 ZFYVE26 KDM5D	7.80e-05	147	56	5	IPR011011
Domain	VWC	CCN5 VWF VWCE	7.93e-05	28	56	3	PF00093
Domain	zf-C5HC2	KDM5B KDM5D	8.78e-05	5	56	2	PF02928
Domain	Znf_C5HC2	KDM5B KDM5D	8.78e-05	5	56	2	IPR004198
Domain	-	LRP1 LRP2 LRP1B	2.16e-04	39	56	3	2.120.10.30
Domain	Tim17/Tim22/Tim23/PMP24	TIMM17B TIMM17A	2.44e-04	8	56	2	IPR003397
Domain	Tim17	TIMM17B TIMM17A	2.44e-04	8	56	2	PF02466
Domain	6-blade_b-propeller_TolB-like	LRP1 LRP2 LRP1B	3.54e-04	46	56	3	IPR011042
Domain	JmjN	KDM5B KDM5D	3.91e-04	10	56	2	SM00545
Domain	JMJN	KDM5B KDM5D	3.91e-04	10	56	2	PS51183
Domain	JmjN	KDM5B KDM5D	3.91e-04	10	56	2	PF02375
Domain	JmjN	KDM5B KDM5D	3.91e-04	10	56	2	IPR003349
Domain	Quinoprot_gluc/sorb_DH	MED16 LRP1	5.72e-04	12	56	2	IPR011041
Domain	TSP_1	CCN5 ADAMTSL5 SSPOP	8.93e-04	63	56	3	PF00090
Domain	-	KDM5B KDM5D	9.04e-04	15	56	2	1.10.150.60
Domain	BRIGHT	KDM5B KDM5D	9.04e-04	15	56	2	SM00501
Domain	ARID_dom	KDM5B KDM5D	9.04e-04	15	56	2	IPR001606
Domain	ARID	KDM5B KDM5D	9.04e-04	15	56	2	PS51011
Domain	ARID	KDM5B KDM5D	9.04e-04	15	56	2	PF01388
Domain	TSP1	CCN5 ADAMTSL5 SSPOP	9.78e-04	65	56	3	SM00209
Domain	TSP1_rpt	CCN5 ADAMTSL5 SSPOP	9.78e-04	65	56	3	IPR000884
Domain	TSP1	CCN5 ADAMTSL5 SSPOP	9.78e-04	65	56	3	PS50092
Domain	C345C	SFRP1 ADAMTSL5	1.17e-03	17	56	2	SM00643
Domain	CTCK_1	VWF SSPOP	1.31e-03	18	56	2	PS01185
Domain	NTR	SFRP1 ADAMTSL5	1.46e-03	19	56	2	PF01759
Domain	Netrin_module_non-TIMP	SFRP1 ADAMTSL5	1.46e-03	19	56	2	IPR018933
Domain	FRI	SFRP1 MFRP	1.62e-03	20	56	2	SM00063
Domain	-	SFRP1 MFRP	1.79e-03	21	56	2	1.10.2000.10
Domain	NTR	SFRP1 ADAMTSL5	2.15e-03	23	56	2	PS50189
Domain	Netrin_domain	SFRP1 ADAMTSL5	2.15e-03	23	56	2	IPR001134
Domain	Frizzled_dom	SFRP1 MFRP	2.34e-03	24	56	2	IPR020067
Domain	JmjC	KDM5B KDM5D	2.34e-03	24	56	2	PF02373
Domain	FZ	SFRP1 MFRP	2.34e-03	24	56	2	PS50038
Domain	Fz	SFRP1 MFRP	2.34e-03	24	56	2	PF01392
Domain	PHD	KDM5B PHF7 KDM5D	2.42e-03	89	56	3	SM00249
Domain	Cys_knot_C	VWF SSPOP	2.53e-03	25	56	2	IPR006207
Domain	CTCK_2	VWF SSPOP	2.53e-03	25	56	2	PS01225
Domain	Znf_PHD	KDM5B PHF7 KDM5D	2.57e-03	91	56	3	IPR001965
Domain	TIMP-like_OB-fold	SFRP1 ADAMTSL5	2.74e-03	26	56	2	IPR008993
Domain	ZF_PHD_2	KDM5B PHF7 KDM5D	2.91e-03	95	56	3	PS50016
Domain	ZF_PHD_1	KDM5B PHF7 KDM5D	3.00e-03	96	56	3	PS01359
Pathway	WP_7OXOC_AND_7BETAHC_PATHWAYS	ACOT1 ACOT6 ACOT2	4.29e-05	27	36	3	M40054
Pathway	REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION	MPL VWF GP1BB	1.31e-04	39	36	3	M10735
Pathway	REACTOME_ENHANCED_BINDING_OF_GP1BA_VARIANT_TO_VWF_MULTIMER_COLLAGEN	VWF GP1BB	1.32e-04	7	36	2	M48265
Pathway	REACTOME_DEFECTS_OF_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN	VWF GP1BB	1.76e-04	8	36	2	M48236
Pathway	WP_OXYSTEROLS_DERIVED_FROM_CHOLESTEROL	ACOT1 ACOT6 ACOT2	2.93e-04	51	36	3	M39754
Pathway	REACTOME_GP1B_IX_V_ACTIVATION_SIGNALLING	VWF GP1BB	4.12e-04	12	36	2	MM15093
Pathway	REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN	VWF GP1BB	4.12e-04	12	36	2	MM15452
Pathway	REACTOME_GP1B_IX_V_ACTIVATION_SIGNALLING	VWF GP1BB	4.12e-04	12	36	2	M27352
Pathway	WP_OMEGA9_FATTY_ACID_SYNTHESIS	ACOT1 ACOT2	5.66e-04	14	36	2	MM15840
Pathway	WP_OMEGA3_OMEGA6_FATTY_ACID_SYNTHESIS	ACOT1 ACOT2	6.52e-04	15	36	2	M39789
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTSL5 SSPOP NOTCH3	6.84e-04	68	36	3	M27303
Pathway	REACTOME_DEFECTS_OF_CONTACT_ACTIVATION_SYSTEM_CAS_AND_KALLIKREIN_KININ_SYSTEM_KKS	VWF GP1BB	7.44e-04	16	36	2	M38996
Pathway	WP_OMEGA3_OMEGA6_FATTY_ACID_SYNTHESIS	ACOT1 ACOT2	7.44e-04	16	36	2	MM15813
Pathway	REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN	VWF GP1BB	7.44e-04	16	36	2	M9450
Pathway	WP_MAMMARY_GLAND_DEVELOPMENT_EMBRYONIC_DEVELOPMENT_STAGE_1_OF_4	SFRP1 NRG3	9.46e-04	18	36	2	M39327
Pathway	REACTOME_DISEASES_OF_HEMOSTASIS	VWF GP1BB	1.06e-03	19	36	2	M48230
Pathway	KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS	ACOT1 ACOT2	1.42e-03	22	36	2	M11673
Pathway	REACTOME_INTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION	VWF GP1BB	1.55e-03	23	36	2	M14766
Pathway	REACTOME_INTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION	VWF GP1BB	1.55e-03	23	36	2	MM14557
Pathway	REACTOME_HDMS_DEMETHYLATE_HISTONES	KDM5B KDM5D	2.47e-03	29	36	2	MM14934
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	GALNT15 ADAMTSL5 SSPOP	2.67e-03	109	36	3	MM15164
Pathway	WP_WNT_SIGNALING_PATHWAY	VANGL2 SFRP1 LRP1	2.74e-03	110	36	3	MM15977
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	GALNT15 ADAMTSL5 SSPOP	2.81e-03	111	36	3	M27416
Pubmed	Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs.	ACOT1 ACOT6 ACOT2	3.94e-08	5	56	3	16940157
Pubmed	A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases.	ACOT1 ACOT6 ACOT2	3.30e-07	9	56	3	16103133
Pubmed	LRP2 mediates folate uptake in the developing neural tube.	LRP1 LRP2 LRP1B	6.46e-07	11	56	3	24639464
Pubmed	Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.	LRP1 LRP2 LRP1B	1.42e-06	14	56	3	15082773
Pubmed	Striking differences of LDL receptor-related protein 1B expression in mouse and human.	LRP1 LRP1B	2.55e-06	2	56	2	15963947
Pubmed	Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.	LRP1 LRP2	2.55e-06	2	56	2	34445520
Pubmed	N1421K mutation in the glycoprotein Ib binding domain impairs ristocetin- and botrocetin-mediated binding of von Willebrand factor to platelets.	VWF GP1BB	2.55e-06	2	56	2	18637125
Pubmed	Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver.	ACOT1 ACOT2	2.55e-06	2	56	2	25114170
Pubmed	von Willebrand factor (VWF)-dependent human platelet activation: porcine VWF utilizes different transmembrane signaling pathways than does thrombin to activate platelets, but both require protein phosphatase function.	VWF GP1BB	2.55e-06	2	56	2	12871509
Pubmed	Acyl-CoA thioesterases belong to a novel gene family of peroxisome proliferator-regulated enzymes involved in lipid metabolism.	ACOT1 ACOT2	2.55e-06	2	56	2	11330065
Pubmed	VWF maturation and release are controlled by 2 regulators of Weibel-Palade body biogenesis: exocyst and BLOC-2.	VWF HPS6	2.55e-06	2	56	2	32614949
Pubmed	MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.	LRP1 LRP2 LRP1B	5.15e-06	21	56	3	21337463
Pubmed	Common fragile sites (CFS) and extremely large CFS genes are targets for human papillomavirus integrations and chromosome rearrangements in oropharyngeal squamous cell carcinoma.	CSMD1 LRP1B	7.63e-06	3	56	2	27636103
Pubmed	Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signaling.	VWF GP1BB	7.63e-06	3	56	2	12860973
Pubmed	Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling.	LRP1 NOTCH3	7.63e-06	3	56	2	20472562
Pubmed	Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism.	ACOT1 ACOT2	7.63e-06	3	56	2	10567408
Pubmed	Shear stress-independent binding of von Willebrand factor-type 2B mutants p.R1306Q & p.V1316M to LRP1 explains their increased clearance.	VWF LRP1	7.63e-06	3	56	2	25728415
Pubmed	Up-Regulated MicroRNA-27b Promotes Adipocyte Differentiation via Induction of Acyl-CoA Thioesterase 2 Expression.	ACOT1 ACOT2	7.63e-06	3	56	2	31930115
Pubmed	Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty Acids Modulates Dengue Virus Serotype 2 Replication.	ACOT1 ACOT2	7.63e-06	3	56	2	35215835
Pubmed	Recombinant von Willebrand factor-insight into structure and function through infusion studies in animals with severe von Willebrand disease.	VWF LRP1	7.63e-06	3	56	2	11992244
Pubmed	Identification of the regulatory elements of the human von Willebrand factor for binding to platelet GPIb. Importance of structural integrity of the regions flanked by the CYS1272-CYS1458 disulfide bond.	VWF GP1BB	7.63e-06	3	56	2	11943773
Pubmed	Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation.	VWF GP1BB	7.63e-06	3	56	2	19808696
Pubmed	Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.	KDM5B KDM5D	1.52e-05	4	56	2	16541399
Pubmed	Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis.	LRP1 LRP2	1.52e-05	4	56	2	12413896
Pubmed	Platelet glycoprotein Ib beta/IX mediates glycoprotein Ib alpha localization to membrane lipid domain critical for von Willebrand factor interaction at high shear.	VWF GP1BB	1.52e-05	4	56	2	21507943
Pubmed	The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.	KDM5B KDM5D	1.52e-05	4	56	2	17320160
Pubmed	Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta).	VWF GP1BB	1.52e-05	4	56	2	12361948
Pubmed	Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases.	ACOT1 ACOT2	1.52e-05	4	56	2	15007068
Pubmed	BLOC-2 subunit HPS6 deficiency affects the tubulation and secretion of von Willebrand factor from mouse endothelial cells.	VWF HPS6	1.52e-05	4	56	2	27889498
Pubmed	Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1.	LRP1 LRP2	1.52e-05	4	56	2	7775583
Pubmed	Role of apolipoprotein E receptors in regulating the differential in vivo neurotrophic effects of apolipoprotein E.	LRP1 LRP2	1.52e-05	4	56	2	11421580
Pubmed	Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex.	VWF GP1BB	1.52e-05	4	56	2	2557900
Pubmed	Genome-wide association study of lung function decline in adults with and without asthma.	CHD7 CSMD1 SVEP1	1.90e-05	32	56	3	22424883
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	LRP1 LRP2 LRP1B NOTCH3	2.19e-05	101	56	4	23382219
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	LRP1 ABTB1 ADCK2 WNK2 NOTCH3	2.49e-05	214	56	5	22199357
Pubmed	ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its Rafts' association.	LRP1 LRP2	2.54e-05	5	56	2	16101684
Pubmed	Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow.	VWF GP1BB	2.54e-05	5	56	2	21037087
Pubmed	Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.	LRP1 LRP2	2.54e-05	5	56	2	19047013
Pubmed	Multiple mitochondrial thioesterases have distinct tissue and substrate specificity and CoA regulation, suggesting unique functional roles.	ACOT1 ACOT2	2.54e-05	5	56	2	31676684
Pubmed	Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509.	LRP1 LRP2	2.54e-05	5	56	2	18685438
Pubmed	Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein.	LRP1 LRP2	3.80e-05	6	56	2	9837937
Pubmed	Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria.	TIMM17B TIMM17A	3.80e-05	6	56	2	23263864
Pubmed	Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.	CCN5 SFRP1 VWF MFRP SVEP1	5.03e-05	248	56	5	24006456
Pubmed	von Willebrand factor binding to platelet GpIb initiates signals for platelet activation.	VWF GP1BB	5.32e-05	7	56	2	1939645
Pubmed	Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3zeta.	VWF GP1BB	5.32e-05	7	56	2	10887121
Pubmed	The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.	LRP1 LRP2	5.32e-05	7	56	2	12169628
Pubmed	Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds.	VANGL2 LRP2	7.09e-05	8	56	2	33500317
Pubmed	ROMO1 is a constituent of the human presequence translocase required for YME1L protease import.	TIMM17B TIMM17A	7.09e-05	8	56	2	30598479
Pubmed	Role of Magmas in protein transport and human mitochondria biogenesis.	TIMM17B TIMM17A	7.09e-05	8	56	2	20053669
Pubmed	LDL receptor-related protein as a component of the midkine receptor.	LRP1 LRP2	9.10e-05	9	56	2	10772929
Pubmed	Biological insights from 108 schizophrenia-associated genetic loci.	ZFYVE21 LRP1 RFTN2 CHADL CSMD1	1.29e-04	303	56	5	25056061
Pubmed	Functional characterization of putative cilia genes by high-content analysis.	PTPDC1 CFAP410	1.39e-04	11	56	2	21289087
Pubmed	Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.	MPL LRP2	1.39e-04	11	56	2	22649097
Pubmed	A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland.	LRP2 ACOT1	1.66e-04	12	56	2	8631881
Pubmed	Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.	TIMM17B MED16 ADCK2 ACOT1 ACOT2 NDUFA8	1.78e-04	515	56	6	31617661
Pubmed	Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart.	VWF NOTCH3	1.96e-04	13	56	2	20558824
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	KDM5B KDM5D	1.96e-04	13	56	2	24619213
Pubmed	Sfrp1 and Sfrp2 are required for normal male sexual development in mice.	VANGL2 SFRP1	1.96e-04	13	56	2	19100252
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	LRP1 LRP2 SSPOP	2.09e-04	71	56	3	33541421
Pubmed	Stage-specific association of apolipoprotein A-I and E in developing mouse retina.	LRP1 LRP2	2.29e-04	14	56	2	17389516
Pubmed	Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia.	MPL VWF	2.29e-04	14	56	2	10981960
Pubmed	Genetic and structural characterization of the human mitochondrial inner membrane translocase.	TIMM17B TIMM17A	2.29e-04	14	56	2	10339406
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	CCN5 ADAMTSL5 SSPOP	2.46e-04	75	56	3	20637190
Pubmed	Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.	VANGL2 SSPOP	2.64e-04	15	56	2	20473291
Pubmed	Genome-scale RNAi screen for host factors required for HIV replication.	CCN5 BCL2L12 SFRP1 ABTB1 ZNF552	2.90e-04	361	56	5	18976975
Pubmed	Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse.	VANGL2 SFRP1	3.01e-04	16	56	2	18257070
Pubmed	A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking.	VANGL2 SFRP1	3.41e-04	17	56	2	28292423
Pubmed	Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.	LRP1 LRP2	3.83e-04	18	56	2	10827173
Pubmed	The Role of Sorting Nexin 17 in Cardiac Development.	VANGL2 LRP1	4.28e-04	19	56	2	34988124
Pubmed	An Ideal PPAR Response Element Bound to and Activated by PPARα.	ACOT1 ACOT2	4.75e-04	20	56	2	26241474
Pubmed	Motor neurons with axial muscle projections specified by Wnt4/5 signaling.	VANGL2 SFRP1	5.76e-04	22	56	2	19285468
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PTPDC1 ZNF875 UVSSA LRP1 CSMD1 NRG3 SSPOP WNK2 NOTCH3	5.81e-04	1489	56	9	28611215
Pubmed	Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium.	VANGL2 SFRP1	6.87e-04	24	56	2	19300477
Pubmed	Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.	GALNT15 LRP2	6.87e-04	24	56	2	31740596
Pubmed	Non-canonical Wnt Signaling through Ryk Regulates the Generation of Somatostatin- and Parvalbumin-Expressing Cortical Interneurons.	VANGL2 SFRP1	8.71e-04	27	56	2	31257105
Pubmed	The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice.	ACOT1 ACOT2	1.01e-03	29	56	2	28364022
Pubmed	Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.	CDC123 LRP1	1.08e-03	30	56	2	21946350
Pubmed	Integral and associated lysosomal membrane proteins.	LRP1 LRP2 ZFYVE26	1.12e-03	126	56	3	17897319
Pubmed	Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study.	LRP2 LRP1B	1.22e-03	32	56	2	25189868
Pubmed	Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.	KDM5B KDM5D	1.30e-03	33	56	2	26864203
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	PTPDC1 ZSWIM8 CDC123 PDE8B HPS6 TBC1D12 CFAP410	1.34e-03	1038	56	7	26673895
Pubmed	Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos.	WNK2 NOTCH3	1.38e-03	34	56	2	7490078
Pubmed	Joint influence of small-effect genetic variants on human longevity.	UVSSA SVEP1	1.38e-03	34	56	2	20834067
Pubmed	WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis.	VANGL2 LRP2	1.46e-03	35	56	2	30940800
Pubmed	Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation.	CCN5 SFRP1	1.46e-03	35	56	2	19185060
Interaction	ANKRD36B interactions	VANGL2 LRP1 LRP2 CHD7 LRP1B	6.71e-07	60	56	5	int:ANKRD36B
Interaction	ZFP41 interactions	LRP1 LRP2 LRP1B NOTCH3	1.89e-05	57	56	4	int:ZFP41
Interaction	ZNF224 interactions	LRP2 LRP1B NOTCH3	2.24e-05	20	56	3	int:ZNF224
Interaction	NTN5 interactions	LRP2 LRP1B NOTCH3	3.95e-05	24	56	3	int:NTN5
Cytoband	Ensembl 112 genes in cytogenetic band chr14q24	ZFYVE26 ACOT1 ACOT6 ACOT2	1.15e-04	200	57	4	chr14q24
Cytoband	14q24.3	ACOT1 ACOT6 ACOT2	2.18e-04	93	57	3	14q24.3
GeneFamily	Acyl-CoA thioesterases	ACOT1 ACOT6 ACOT2	8.62e-07	10	36	3	41
GeneFamily	Low density lipoprotein receptors	LRP1 LRP2 LRP1B	2.05e-06	13	36	3	634
GeneFamily	AT-rich interaction domain containing	KDM5B KDM5D	3.98e-04	15	36	2	418
GeneFamily	PHD finger proteins	KDM5B PHF7 KDM5D	7.56e-04	90	36	3	88
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5B KDM5D	1.03e-03	24	36	2	485
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	ZFYVE21 ZFYVE26	1.73e-03	31	36	2	81
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CSMD1 SVEP1	5.74e-03	57	36	2	1179
Coexpression	NABA_CORE_MATRISOME	CCN5 VWF CHADL VWCE ZP4 SSPOP SVEP1	1.94e-06	275	56	7	M5884
Coexpression	NABA_ECM_GLYCOPROTEINS	CCN5 VWF VWCE ZP4 SSPOP SVEP1	3.85e-06	196	56	6	M3008
Coexpression	NABA_MATRISOME	CCN5 SFRP1 VWF ADAMTSL5 CLEC17A CHADL NRG3 VWCE ZP4 SSPOP SVEP1	9.27e-06	1026	56	11	M5889
Coexpression	NABA_CORE_MATRISOME	CCN5 VWF CHADL VWCE SSPOP SVEP1	2.38e-05	270	56	6	MM17057
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HRGL3	GALNT15 PDE8B LRP1 LRP2 RFTN2 MFRP LRP1B SSPOP	2.84e-05	574	56	8	M39056
Coexpression	NABA_MATRISOME	CCN5 SFRP1 VWF ADAMTSL5 CHADL NRG3 MFRP VWCE SSPOP SVEP1	4.82e-05	1008	56	10	MM17056
Coexpression	NABA_ECM_GLYCOPROTEINS	CCN5 VWF VWCE SSPOP SVEP1	5.51e-05	191	56	5	MM17059
Coexpression	GSE19888_CTRL_VS_TCELL_MEMBRANES_ACT_MAST_CELL_PRETREAT_A3R_INH_UP	TIMM17B ZFYVE21 RFTN2 ACOT2 GP1BB	6.85e-05	200	56	5	M7335
Coexpression	DELYS_THYROID_CANCER_DN	SFRP1 FCGBP LRP2 LRP1B SSPOP	1.40e-04	233	56	5	M13273
Coexpression	HATADA_METHYLATED_IN_LUNG_CANCER_UP	GALNT15 PDE8B ZNF875 CSMD1 VWCE CFAP410	1.51e-04	377	56	6	M19508
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GALNT15 CCN5 SFRP1 LRP1 LRP1B SVEP1	1.40e-07	186	57	6	7582b5154d8e5a4434817b5ab77a10b789ea2288
ToppCell	LA\|World / Chamber and Cluster_Paper	GALNT15 PDE8B LRP1 LRP2 LRP1B SVEP1	1.74e-07	193	57	6	d4bf89437216baf489ea0239136dcedf3b6714af
ToppCell	(0)_MSCs-(00)_Lepr-MSC\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	CCN5 SFRP1 CSMD1 SVEP1 NOTCH3	4.02e-06	186	57	5	f0d156167d7cc2cd8a76e5a364233e9f2170bc01
ToppCell	(0)_MSCs\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	CCN5 SFRP1 CSMD1 SVEP1 NOTCH3	4.02e-06	186	57	5	a832c1e0035bcd559722eccf262c145deb3494c7
ToppCell	IPF-Stromal-Fibroblast\|Stromal / Disease state, Lineage and Cell class	GALNT15 CCN5 SFRP1 LRP1 SVEP1	4.94e-06	194	57	5	da3e1d39575969a069ef43e552afe94b2f441d0b
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GALNT15 CCN5 SFRP1 LRP1 SVEP1	5.07e-06	195	57	5	f54bc4454270ff06e85596f98199372b50d0179f
ToppCell	Fibroblasts-CD34+_Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	GALNT15 CCN5 SFRP1 LRP1 SVEP1	5.59e-06	199	57	5	13ff7409e200a0b46cdb7924d15ef33639693622
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GALNT15 CCN5 SFRP1 LRP1 SVEP1	5.73e-06	200	57	5	933b5b400e48a511ba0a056be1d33d3610b5f10d
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GALNT15 CCN5 SFRP1 LRP1 SVEP1	5.73e-06	200	57	5	17ffdbc13332bd3ed1d54abcd7af20267dd4b234
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GALNT15 CCN5 SFRP1 LRP1 SVEP1	5.73e-06	200	57	5	db6281b5d4032116310db379d9175d790994c99c
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GALNT15 CCN5 SFRP1 LRP1 SVEP1	5.73e-06	200	57	5	cfea2f9d85646c9b722150551ff2e8fc4f6cc98a
ToppCell	Tracheal-10x3prime_v2-Stromal-Fibroblastic-Fibro_adventitial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	GALNT15 CCN5 SFRP1 LRP1 SVEP1	5.73e-06	200	57	5	9dd2eb70c1cc146935f5aff27373dfc65cb8c098
ToppCell	Parenchymal-10x3prime_v2-Stromal-Fibroblastic-Fibro_adventitial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	GALNT15 CCN5 SFRP1 LRP1 SVEP1	5.73e-06	200	57	5	fc3c4778841c4b8bac0afb458352614b2c460617
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GALNT15 CCN5 SFRP1 LRP1 SVEP1	5.73e-06	200	57	5	a2bb67a06757f19be3f56f8cb5bb7e2affa5f4ed
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GALNT15 CCN5 SFRP1 LRP1 SVEP1	5.73e-06	200	57	5	f6cf98aad53aa8b3fa02cf874d6f7cd75530a213
ToppCell	Tracheal-10x3prime_v2-Stromal-Fibroblastic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	GALNT15 CCN5 SFRP1 LRP1 SVEP1	5.73e-06	200	57	5	5fdca7959134a5c8e06e5d6d14aafe34b963aef2
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GALNT15 CCN5 SFRP1 LRP1 SVEP1	5.73e-06	200	57	5	2e4ab7fbd94d3d865ef6188d3b4916d2bf1b8d89
ToppCell	5'-Adult-LargeIntestine-Mesenchymal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GALNT15 CCN5 SFRP1 LRP1 SVEP1	5.73e-06	200	57	5	5a87bb8eb1c6bd2fbc357e1528e15ba1c0051438
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GALNT15 CCN5 SFRP1 LRP1 SVEP1	5.73e-06	200	57	5	665df8391d2ebcfc6536318612f4992852b5e2b8
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GALNT15 CCN5 SFRP1 LRP1 SVEP1	5.73e-06	200	57	5	10f0c20ba7c71d9e2e177597f85b41cb40f0d878
ToppCell	367C-Fibroblasts-Fibroblast-D-\|367C / Donor, Lineage, Cell class and subclass (all cells)	CCN5 SFRP1 LRP1 SVEP1	4.53e-05	154	57	4	dd3d34f065820e706515a13619f19a5b12734c8e
ToppCell	367C-Fibroblasts-Fibroblast-D\|367C / Donor, Lineage, Cell class and subclass (all cells)	CCN5 SFRP1 LRP1 SVEP1	4.53e-05	154	57	4	4bfda1c41efbb86d829b3797d1168bf2587c3c97
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GALNT15 IL17RE PDE8B NRG3	6.50e-05	169	57	4	987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP IL17RE CSMD1 WNK2	6.65e-05	170	57	4	a121e10099faaeb60251eec162f38caf7c4238c2
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD8-Tem/emra_CD8\|GI_small-bowel / Manually curated celltypes from each tissue	LRP2 SVEP1 WNK2 NOTCH3	6.80e-05	171	57	4	f28684ea0e74a22f4c140658496068e28a6d3605
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GALNT15 SFRP1 LRP1 SVEP1	6.96e-05	172	57	4	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Mesenchymal-Cilia-bearing_cell\|5w / Sample Type, Dataset, Time_group, and Cell type.	MED16 FKRP ZNF552 CHADL	7.11e-05	173	57	4	d4cbeae262abfa30d8c5452285d3261a96875610
ToppCell	Adult-Epithelial-lung_goblet_cell-D231\|Adult / Lineage, Cell type, age group and donor	FCGBP PDE8B WNK2 NOTCH3	7.27e-05	174	57	4	7d2f802f493f19a068e097b2909a9000e2160266
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CCN5 ADAMTSL5 CHADL NOTCH3	7.27e-05	174	57	4	9f2e253694eb5860c00528fda31c305c6de8a2a1
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP IL17RE CSMD1 WNK2	7.44e-05	175	57	4	f7cd2ef79d91d64976fcdb5f1e7343b24ba27456
ToppCell	343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	SFRP1 LRP1 LRP1B SVEP1	7.60e-05	176	57	4	2e94bbe17c0bb65dc58b4ebc0cb829258bd7373b
ToppCell	343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)\|343B / Donor, Lineage, Cell class and subclass (all cells)	SFRP1 LRP1 LRP1B SVEP1	7.60e-05	176	57	4	f33ab41d121b59d871ad7d48ca021524a027d2ef
ToppCell	Adult-Endothelial-endothelial_cell_of_bronchial_vessel-D175\|Adult / Lineage, Cell type, age group and donor	GALNT15 VWF RFTN2 LRP1B	7.77e-05	177	57	4	c9f269765c7d5d29caab75910e51645606ed562e
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GALNT15 SFRP1 IL17RE LRP2	8.47e-05	181	57	4	3f4d5d79c1286614514b0e8134079d6128a2a23e
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GALNT15 SFRP1 IL17RE LRP2	8.47e-05	181	57	4	330d4322f4c4373f706273c1f4e218b59051b7fd
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 CSMD1 LRP1B SSPOP	9.03e-05	184	57	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 CSMD1 LRP1B SSPOP	9.03e-05	184	57	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 CSMD1 LRP1B SSPOP	9.03e-05	184	57	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D122\|Adult / Lineage, Cell type, age group and donor	GALNT15 CCN5 RFTN2 SVEP1	9.03e-05	184	57	4	2b7e6f91e11c228f0521e099886867d9e998e78d
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SFRP1 LRP1 VWCE SVEP1	9.22e-05	185	57	4	9faa35ceb89ccd2979072286f063687c9f846ce3
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D231\|Adult / Lineage, Cell type, age group and donor	GALNT15 CCN5 SFRP1 SVEP1	9.22e-05	185	57	4	fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCell	facs-Heart-LA-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCN5 SFRP1 LRP1 SVEP1	9.61e-05	187	57	4	1669df899b1759c338ffce196fe009840123cfcd
ToppCell	facs-Heart-LA-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCN5 SFRP1 LRP1 SVEP1	9.61e-05	187	57	4	f3ef3f5a761f8306edc39bf16e76e44aae6fa7f6
ToppCell	Control-Fibroblasts-Adventitial_FB\|Control / group, cell type (main and fine annotations)	GALNT15 CCN5 LRP1 SVEP1	9.81e-05	188	57	4	706a26c372add839d947749f0521a0e1f5c9b0ec
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GALNT15 CCN5 SFRP1 SVEP1	9.81e-05	188	57	4	e18065bbc26d6f3774fd1f478fb41d8fb555fa26
ToppCell	343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	FCGBP PDE8B WNK2 NOTCH3	1.00e-04	189	57	4	b06471b1bebb990d5146bddfb8002401c6b099a0
ToppCell	343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)\|343B / Donor, Lineage, Cell class and subclass (all cells)	FCGBP PDE8B WNK2 NOTCH3	1.00e-04	189	57	4	a8246acf31f02c85421268245afb651aa8788f14
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CCN5 SFRP1 LRP1 SVEP1	1.00e-04	189	57	4	9e1a51997ef9b6999d9b40cf0a55e561e3b4a84c
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GALNT15 CCN5 LRP1 SVEP1	1.00e-04	189	57	4	d531399749409d614adca13d181830c6e3287508
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GALNT15 LRP2 RFTN2 CHADL	1.02e-04	190	57	4	6b101359f397020a21e2bfd15851cb48e71f4502
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GALNT15 LRP2 RFTN2 CHADL	1.02e-04	190	57	4	396b7225c2430db3dc55a3d0db70239b71987229
ToppCell	(7)_Epithelial-G_(Club-Clara_cells)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	FCGBP PDE8B WNK2 NOTCH3	1.02e-04	190	57	4	593fd1451038b155826a48de4caa38f44406d0b9
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GALNT15 CCN5 LRP1 SVEP1	1.04e-04	191	57	4	4e4488380379ed29d7898bae4e24221e7c67eb9d
ToppCell	facs-Trachea-nan-18m-Mesenchymal-fibroblast\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP1 ADAMTSL5 LRP1 SVEP1	1.04e-04	191	57	4	783e8c436de90623bb1bc4117270d60c8c8a9461
ToppCell	facs-Trachea-nan-18m-Mesenchymal\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP1 ADAMTSL5 LRP1 SVEP1	1.06e-04	192	57	4	ceadfbce037bef15523916ba091bb6c0d752cce5
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-G_(Club-Clara_cells)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	FCGBP PDE8B WNK2 NOTCH3	1.06e-04	192	57	4	c7c232545fad8ad327ab94bd0def8dc5daacd03d
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCN5 LRP1 CSMD1 SVEP1	1.06e-04	192	57	4	853a930e0641ffb50cbb4cef5837c70d75c3fc39
ToppCell	facs-Trachea-nan-18m-Mesenchymal-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP1 ADAMTSL5 LRP1 SVEP1	1.06e-04	192	57	4	f388a336062880609724e91bf51bd0f9c4da2f69
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCN5 LRP1 CSMD1 SVEP1	1.06e-04	192	57	4	49281626ecad0456fdbded2378b7028d7b589686
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GALNT15 SFRP1 LRP1B SVEP1	1.06e-04	192	57	4	11867f30f0b420c18cb0b34d3990237aa737a0e8
ToppCell	15-Trachea-Endothelial-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	GALNT15 TMEM88 VWF NRG3	1.09e-04	193	57	4	6ea0444fc3dc156997129387184e6418947f4b12
ToppCell	343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FCGBP PDE8B WNK2 NOTCH3	1.09e-04	193	57	4	8ede7038a222c7e7ecaf7e86520823cf606cbee7
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCN5 SFRP1 LRP1 SVEP1	1.09e-04	193	57	4	0a665531d581d4e3941e29d3f95569da8f166447
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCN5 SFRP1 LRP1 SVEP1	1.09e-04	193	57	4	24ce1f37cca655415410d2403a52d1ebb3332280
ToppCell	343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FCGBP PDE8B WNK2 NOTCH3	1.09e-04	193	57	4	0e7d7adfaa7191e34038fcda6677561ae13934eb
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP IL17RE ACOT1 NOTCH3	1.09e-04	193	57	4	22ebc3f586eb0aabc5785e468c88d7416c624ff4
ToppCell	15-Trachea-Endothelial\|Trachea / Age, Tissue, Lineage and Cell class	GALNT15 TMEM88 VWF NRG3	1.09e-04	193	57	4	b1ebf8df2d55e2938e5a495ea68b80c4ac216dc0
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SFRP1 LRP1 RFTN2 SVEP1	1.11e-04	194	57	4	ae7df037592f1c20c9d32be15fe6fc3c562ebeb1
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCN5 SFRP1 LRP1 SVEP1	1.11e-04	194	57	4	2d0cff9dc538a14518741e2a96d9d78442c81a72
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SFRP1 LRP1 RFTN2 SVEP1	1.11e-04	194	57	4	240d122dcb9dd1ab2867503ad85869853adcacae
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GALNT15 CCN5 LRP1 SVEP1	1.13e-04	195	57	4	fc43cd295f2cc3f6e9442232e028944f011c82cc
ToppCell	390C-Myeloid-Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	FCGBP LRP1 ACOT1 ACOT2	1.13e-04	195	57	4	ba494be431916d43c1d480f65bed674c0722c710
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SFRP1 PDE8B LRP1 SVEP1	1.15e-04	196	57	4	ba869f7a86f37fd6d84d6ad69baca0e0faaf5887
ToppCell	Control-Stromal-Fibroblast\|Control / Disease state, Lineage and Cell class	GALNT15 CCN5 SFRP1 SVEP1	1.15e-04	196	57	4	7ca94477498a84cafcdd9933ee92a6cbde76c70e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SFRP1 PDE8B LRP1 SVEP1	1.15e-04	196	57	4	30ad56d49000e4ddce73b4443b3994564bd1e2d6
ToppCell	Control-Stromal-Fibroblast\|World / Disease state, Lineage and Cell class	GALNT15 CCN5 SFRP1 SVEP1	1.15e-04	196	57	4	1ec7a4daa51b3156db97e1fd6cb925ad311bb4b5
ToppCell	droplet-Limb_Muscle-nan-24m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCN5 SFRP1 LRP1 SVEP1	1.15e-04	196	57	4	61bee32ca299219f31a30b57124e44e85b798e9f
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SFRP1 LRP1 SVEP1 NOTCH3	1.17e-04	197	57	4	b9745e382baa2725dfcae060701fb53f6c8a31fa
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GALNT15 CCN5 LRP1 SVEP1	1.17e-04	197	57	4	ab5d3ebc73bd7cfc64381d14b92878b370205186
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GALNT15 CCN5 SFRP1 LRP1	1.17e-04	197	57	4	c747c496ac090309b7f8a3e9d840928f12c83f2f
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SFRP1 LRP1 SVEP1 NOTCH3	1.17e-04	197	57	4	5afddde4e2b5cd55abe11e9b9efae02dbdc3da3a
ToppCell	5'-Adult-Appendix-Mesenchymal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GALNT15 CCN5 LRP1 SVEP1	1.17e-04	197	57	4	b11a5d909942a4299cbc0b27332b1a3f66f3bccd
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo-stroma-adipo-CAR\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SFRP1 LRP1 SVEP1 NOTCH3	1.17e-04	197	57	4	1baffd087ca194a7355fefbb3bf67befb14fe2de
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GALNT15 CCN5 LRP1 SVEP1	1.17e-04	197	57	4	71786e9432e2d649f5d86f639abb25e7102deb67
ToppCell	tumor_Lung-Fibroblasts-COL14A1+_matrix_FBs\|tumor_Lung / Location, Cell class and cell subclass	CCN5 SFRP1 LRP1 SVEP1	1.20e-04	198	57	4	74f2c7ef702b25a5b99e56121229e678ed992524
ToppCell	5'-Adult-Distal_Rectal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GALNT15 CCN5 SFRP1 WNK2	1.20e-04	198	57	4	db26c20321f9ab102d6484f22ddb2bde684067b1
ToppCell	COPD-Stromal-Fibroblast\|World / Disease state, Lineage and Cell class	GALNT15 CCN5 SFRP1 SVEP1	1.20e-04	198	57	4	2f13c0b3372af53d1bd85f9546f315c878580a71
ToppCell	distal-mesenchymal-Adventitial_Fibroblast-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GALNT15 CCN5 SFRP1 SVEP1	1.20e-04	198	57	4	bfd720e2dae3b6b3dc2bf8b2096c554fd456e756
ToppCell	COPD-Stromal-Fibroblast\|COPD / Disease state, Lineage and Cell class	GALNT15 CCN5 SFRP1 SVEP1	1.20e-04	198	57	4	7904af61473cb20064f7a3a1e1bfe8d5913cf317
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GALNT15 CCN5 SFRP1 SVEP1	1.22e-04	199	57	4	4032f03a4165f5f2a90ef1d8315cc743ce9075bb
ToppCell	distal-2-mesenchymal-Adventitial_Fibroblast\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GALNT15 CCN5 SFRP1 SVEP1	1.22e-04	199	57	4	97b475f9110ef7bb29d9cf2109b7e43177830f05
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GALNT15 CCN5 LRP1 SVEP1	1.22e-04	199	57	4	1fd7bbb8727607e6507848602a19bc86882ef2d5
ToppCell	367C-Fibroblasts-Fibroblast-E-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CCN5 SFRP1 LRP1 SVEP1	1.22e-04	199	57	4	2aed8f4a225a3762a5e7ce99aacad9b2a37d61f1
ToppCell	367C-Fibroblasts-Fibroblast-E\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CCN5 SFRP1 LRP1 SVEP1	1.22e-04	199	57	4	c40ca26345753a2197bd9389d7323f7491c1e11d
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-AF2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GALNT15 CCN5 SFRP1 SVEP1	1.22e-04	199	57	4	993fa050a095017135a6e723c77cd38b9d782e58
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GALNT15 CCN5 LRP1 SVEP1	1.22e-04	199	57	4	9672230aa0bc6a7289050c955f5154ca183a5159
ToppCell	distal-mesenchymal-Adventitial_Fibroblast-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GALNT15 CCN5 SFRP1 SVEP1	1.22e-04	199	57	4	6e8a44e46b46e87b81dbfc56fcbbcde166fd00fe
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GALNT15 CCN5 LRP1 SVEP1	1.22e-04	199	57	4	e18abe678da293bd01fae55e2f9ab6fdd643d02d
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GALNT15 CCN5 SFRP1 SVEP1	1.22e-04	199	57	4	f835e7ffe976843b0edbf695762d463da85793f3
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GALNT15 CCN5 SFRP1 SVEP1	1.22e-04	199	57	4	4e128c705ad36fd840582848f278770f356fcc8b
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5B KDM5D	1.82e-05	4	52	2	DOID:0060809 (implicated_via_orthology)
Disease	Bernard-Soulier syndrome (is_implicated_in)	VWF GP1BB	1.82e-05	4	52	2	DOID:2217 (is_implicated_in)
Disease	essential thrombocythemia (is_implicated_in)	MPL VWF	4.55e-05	6	52	2	DOID:2224 (is_implicated_in)
Disease	X-16935 measurement	ACOT6 ACOT2	6.36e-05	7	52	2	EFO_0800763
Disease	X-24747 measurement	ACOT6 ACOT2	8.47e-05	8	52	2	EFO_0022135
Disease	X-17653 measurement	ACOT6 ACOT2	1.09e-04	9	52	2	EFO_0800783
Disease	X-11308 measurement	ACOT6 ACOT2	1.66e-04	11	52	2	EFO_0800693
Disease	Migraine Disorders	LRP1 NOTCH3	2.35e-04	13	52	2	C0149931
Disease	undecenoylcarnitine (C11:1) measurement	ACOT6 ACOT2	2.35e-04	13	52	2	EFO_0800588
Disease	Proteinuria	VWF LRP2	3.15e-04	15	52	2	HP_0000093
Disease	X-17654 measurement	ACOT6 ACOT2	3.15e-04	15	52	2	EFO_0800784
Disease	amygdala volume change measurement	CSMD1 SPATA31C1	3.60e-04	16	52	2	EFO_0021490
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5B KDM5D	3.60e-04	16	52	2	DOID:0050888 (implicated_via_orthology)
Disease	pneumonia, COVID-19	GALNT15 CSMD1 LRP1B	1.05e-03	113	52	3	EFO_0003106, MONDO_0100096
Disease	lysophosphatidylethanolamine 22:6 measurement	GALNT15 NRG3	1.12e-03	28	52	2	EFO_0010371
Disease	longevity	UVSSA CSMD1 MFRP SVEP1	1.58e-03	284	52	4	EFO_0004300
Disease	fasting blood glucose measurement	CDC123 CSMD1 NRG3 WNK2	1.64e-03	287	52	4	EFO_0004465
Disease	lysophosphatidylethanolamine 18:1 measurement	GALNT15 LRP1B	1.65e-03	34	52	2	EFO_0010368
Disease	pack-years measurement, systolic blood pressure	LRP2 LRP1B	1.65e-03	34	52	2	EFO_0006335, EFO_0006526

Protein segments in the cluster

Peptide	Gene	Start	Entry
PLLWREELEPCGTAC	VANGL2	131	Q9ULK5
WASPLEDPLRSCCLV	TBC1D12	191	O60347
ILEPAGRCCWDEPVR	ACOT1	6	Q86TX2
SECPRDARLCWLLLG	ADCK2	31	Q7Z695
LPRLRVLWLAENPCC	CFAP410	86	O43822
RVWSAPLPRCVAECG	CSMD1	1091	Q96PZ7
LCPFLGFRPEACWER	BCL2L12	11	Q9HB09
TLILEPAGRCCWDEP	ACOT2	66	P49753
PAGRCCWDEPVRIAV	ACOT2	71	P49753
ILEPAGRCCWDEPLR	ACOT6	6	Q3I5F7
CPELRNIPWRCVVID	CHD7	1091	Q9P2D1
LPEECRLSPSRECWT	RFTN2	446	Q52LD8
PRGLRPDCRFSWLCV	MFRP	56	Q9BY79
AEPPRELRCSDCIVW	NRG3	46	P56975
PRHWLCDGERDCPDG	LRP1B	2776	Q9NZR2
LDGLCIPLRWRCDGD	LRP1	1071	Q07954
IIPFLRPGCCVLVWR	IL17RE	421	Q8NFR9
IPRGIWRCPKCILAE	KDM5D	351	Q9BY66
LGANPWRCDCRLVPL	GP1BB	86	P13224
CECHPGWLEPLLSRI	GALNT15	286	Q8N3T1
DVANPCRPLDLCIEW	PDE8B	781	O95263
CRPLDLCIEWAGRIS	PDE8B	786	O95263
REAACLCPPGWVGER	NOTCH3	61	Q9UM47
LCPPGWVGERCQLED	NOTCH3	66	Q9UM47
WLCPHCRRSEKPPLE	KDM5B	1216	Q9UGL1
PDRRCIPQSWVCDGD	LRP2	2961	P98164
AWERICGERDPFILC	PTPDC1	626	A2A3K4
CLLERLPWSPVVCVD	OC90	361	Q02509
RCLRLPGEEPCWGDS	ADAMTSL5	71	Q6ZMM2
LWICCRDEGPASEPD	MED16	696	Q9Y2X0
LRKWCELIPGAEFRC	CDC123	166	O75794
LGEWRRPDFCPLQCP	FCGBP	4726	Q9Y6R7
VPLCSEDVRLPSWDC	CCN5	131	O76076
ERWTPPCCLRALRET	FKRP	311	Q9H9S5
ALDALRPWDLRCPGD	CHADL	346	Q6NUI6
CLCQLEPRWLPPFVE	HPS6	571	Q86YV9
CRWEEKDPRRCLEEG	NDUFA8	46	P51970
DWLFPRRCPKIREEC	EPPIN	26	O95925
WCRAPRPDGRLCERQ	UVSSA	566	Q2YD98
DLWDRVQCLQGPCRP	SSPOP	4691	A2VEC9
PVCWLCLREPGDPEK	PHF7	31	Q9BWX1
CRECPRGLEETWDLL	SPATA31C1	96	P0DKV0
CLDRPIYPCRWLCEA	SFRP1	121	Q8N474
PEGWMGRLCEEPICI	SVEP1	3491	Q4LDE5
PAIEGKNCLRCWPEL	TEX51	11	A0A1B0GUA7
DCALPPELRGDLWEL	ABTB1	246	Q969K4
VELWGLLDCRRITCP	CLEC17A	241	Q6ZS10
LLDCRRITCPEGWLP	CLEC17A	246	Q6ZS10
AWREPGRCELNCPKG	VWF	641	P04275
MPCPELACPREEWRL	VWCE	536	Q96DN2
LACPREEWRLGPGQC	VWCE	541	Q96DN2
PEPRDPLDCWACAVL	TMEM88	16	Q6PEY1
RCCPRDRYPIWENCE	MPL	321	P40238
IPGRCCVLERRIVPW	UBE2Q2L	61	H0YL09
REPCPWRIVDDCGGA	TIMM17B	6	O60830
REPCPWRIVDDCGGA	TIMM17A	6	Q99595
EWACLLRPLRGREPE	ZSWIM8	331	A7E2V4
ERLLPTEEPSVWCEC	ZNF552	231	Q9H707
LEEPQWVPDKECRRC	ZFYVE21	36	Q9BQ24
ERGEAPWREERKCPL	ZNF875	86	P10072
PWREERKCPLDLCPE	ZNF875	91	P10072
TLPCLPWRRAACGAV	WNK2	1351	Q9Y3S1
ELCEEWGCLYPIPRE	ZFYVE26	1561	Q68DK2
DWCDSIPARDRLPCA	ZP4	141	Q12836