Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	CERKL SMG1 FLT1 FLT3 SPEG PTDSS1 OBSCN DGKD ITPKA PTK7 ITPKB FCSK MYO3A TRNT1 AATK CSNK1A1 MAP4K5 PIK3R1 POLR1B MAPK3	3.02e-05	938	152	20	GO:0016772
GeneOntologyMolecularFunction	kinase activity	CERKL SMG1 FLT1 FLT3 SPEG OBSCN DGKD ITPKA PTK7 ITPKB FCSK MYO3A AATK CSNK1A1 MAP4K5 PIK3R1 MAPK3	7.42e-05	764	152	17	GO:0016301
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	SMG1 FLT1 FLT3 SPEG OBSCN DGKD ITPKA PTK7 ITPKB FCSK MYO3A AATK CSNK1A1 MAP4K5 PIK3R1 MAPK3	1.04e-04	709	152	16	GO:0016773
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH14 DNAH8 DYNC1H1	3.24e-04	18	152	3	GO:0008569
GeneOntologyMolecularFunction	inositol-1,4,5-trisphosphate 3-kinase activity	ITPKA ITPKB	3.42e-04	4	152	2	GO:0008440
GeneOntologyMolecularFunction	calmodulin binding	MAP6 OBSCN RYR2 ITPKA ITPKB MYO3A SLC9A1 PIK3R1	3.88e-04	230	152	8	GO:0005516
GeneOntologyMolecularFunction	phosphatidylinositol-3,4,5-trisphosphate binding	PIRT INPPL1 OBSCN FCHSD2	5.24e-04	49	152	4	GO:0005547
GeneOntologyMolecularFunction	inositol tetrakisphosphate kinase activity	ITPKA ITPKB	5.67e-04	5	152	2	GO:0051765
GeneOntologyMolecularFunction	inositol trisphosphate kinase activity	ITPKA ITPKB	5.67e-04	5	152	2	GO:0051766
Domain	Dynein_heavy_chain_D4_dom	DNAH14 DNAH8 DYNC1H1	1.77e-04	14	151	3	IPR024317
Domain	Dynein_HC_stalk	DNAH14 DNAH8 DYNC1H1	1.77e-04	14	151	3	IPR024743
Domain	MT	DNAH14 DNAH8 DYNC1H1	1.77e-04	14	151	3	PF12777
Domain	AAA_8	DNAH14 DNAH8 DYNC1H1	1.77e-04	14	151	3	PF12780
Domain	Pax2_C	PAX2 PAX5	1.94e-04	3	151	2	IPR022130
Domain	Pax2_C	PAX2 PAX5	1.94e-04	3	151	2	PF12403
Domain	DHC_fam	DNAH14 DNAH8 DYNC1H1	2.19e-04	15	151	3	IPR026983
Domain	Dynein_heavy	DNAH14 DNAH8 DYNC1H1	2.19e-04	15	151	3	PF03028
Domain	Dynein_heavy_dom	DNAH14 DNAH8 DYNC1H1	2.19e-04	15	151	3	IPR004273
Domain	Homeobox_KN	TGIF2LY MKX TGIF2LX	3.24e-04	17	151	3	PF05920
Domain	Homeobox_KN_domain	TGIF2LY MKX TGIF2LX	3.24e-04	17	151	3	IPR008422
Domain	PP2A_PR55_CS	PPP2R2D PPP2R2B	3.85e-04	4	151	2	IPR018067
Domain	PP2A_PR55	PPP2R2D PPP2R2B	3.85e-04	4	151	2	IPR000009
Domain	PR55_2	PPP2R2D PPP2R2B	3.85e-04	4	151	2	PS01025
Domain	PR55_1	PPP2R2D PPP2R2B	3.85e-04	4	151	2	PS01024
Domain	-	PPP2R2D NBEA WDFY4 SEMA3A NBAS PPP2R2B TBC1D31 PRPF4 WDR87 DCAF7	3.86e-04	333	151	10	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	PPP2R2D NBEA WDFY4 SEMA3A NBAS PPP2R2B TBC1D31 PRPF4 WDR87 DCAF7	4.05e-04	335	151	10	IPR015943
Domain	WD_REPEATS_1	PPP2R2D NBEA WDFY4 NBAS PPP2R2B TBC1D31 PRPF4 WDR87 DCAF7	4.41e-04	278	151	9	PS00678
Domain	WD_REPEATS_2	PPP2R2D NBEA WDFY4 NBAS PPP2R2B TBC1D31 PRPF4 WDR87 DCAF7	4.53e-04	279	151	9	PS50082
Domain	WD_REPEATS_REGION	PPP2R2D NBEA WDFY4 NBAS PPP2R2B TBC1D31 PRPF4 WDR87 DCAF7	4.53e-04	279	151	9	PS50294
Domain	Kinase-like_dom	SMG1 FLT1 FLT3 SPEG OBSCN CHD9 ARHGAP35 PTK7 MYO3A AATK CSNK1A1 MAP4K5 MAPK3	4.67e-04	542	151	13	IPR011009
Domain	RabGAP-TBC	SGSM1 TBC1D2B TBC1D31 TBC1D10A	8.84e-04	53	151	4	PF00566
Domain	Rab-GTPase-TBC_dom	SGSM1 TBC1D2B TBC1D31 TBC1D10A	1.02e-03	55	151	4	IPR000195
Domain	TBC_RABGAP	SGSM1 TBC1D2B TBC1D31 TBC1D10A	1.02e-03	55	151	4	PS50086
Domain	PROTEIN_KINASE_TYR	FLT1 FLT3 OBSCN PTK7 AATK	1.15e-03	97	151	5	PS00109
Domain	Tyr_kinase_AS	FLT1 FLT3 OBSCN PTK7 AATK	1.15e-03	97	151	5	IPR008266
Domain	WD40	PPP2R2D NBEA WDFY4 PPP2R2B TBC1D31 PRPF4 WDR87 DCAF7	1.24e-03	259	151	8	PF00400
Domain	IPK	ITPKA ITPKB	1.33e-03	7	151	2	PF03770
Domain	IPK	ITPKA ITPKB	1.33e-03	7	151	2	IPR005522
Domain	WD40	PPP2R2D NBEA WDFY4 PPP2R2B TBC1D31 PRPF4 WDR87 DCAF7	1.54e-03	268	151	8	SM00320
Domain	WD40_repeat	PPP2R2D NBEA WDFY4 PPP2R2B TBC1D31 PRPF4 WDR87 DCAF7	1.69e-03	272	151	8	IPR001680
Domain	Tyr_kinase_rcpt_3_CS	FLT1 FLT3	1.76e-03	8	151	2	IPR001824
Domain	DHC_N1	DNAH8 DYNC1H1	1.76e-03	8	151	2	PF08385
Domain	TMC	TMC1 TMC6	1.76e-03	8	151	2	PF07810
Domain	RECEPTOR_TYR_KIN_III	FLT1 FLT3	1.76e-03	8	151	2	PS00240
Domain	PH-BEACH_dom	NBEA WDFY4	1.76e-03	8	151	2	IPR023362
Domain	-	NBEA WDFY4	1.76e-03	8	151	2	2.30.29.40
Domain	PH_BEACH	NBEA WDFY4	1.76e-03	8	151	2	PS51783
Domain	Dynein_heavy_dom-1	DNAH8 DYNC1H1	1.76e-03	8	151	2	IPR013594
Domain	TMC	TMC1 TMC6	1.76e-03	8	151	2	IPR012496
Domain	IG_LIKE	HFE FLT1 FLT3 DSCAM SPEG AZGP1 OBSCN PTK7 SEMA3A CD80 IL1R1	2.19e-03	491	151	11	PS50835
Domain	PAX	PAX2 PAX5	2.25e-03	9	151	2	SM00351
Domain	PAIRED_2	PAX2 PAX5	2.25e-03	9	151	2	PS51057
Domain	BEACH	NBEA WDFY4	2.25e-03	9	151	2	PS50197
Domain	Beach	NBEA WDFY4	2.25e-03	9	151	2	PF02138
Domain	-	NBEA WDFY4	2.25e-03	9	151	2	1.10.1540.10
Domain	PAIRED_1	PAX2 PAX5	2.25e-03	9	151	2	PS00034
Domain	Beach	NBEA WDFY4	2.25e-03	9	151	2	SM01026
Domain	Paired_dom	PAX2 PAX5	2.25e-03	9	151	2	IPR001523
Domain	BEACH_dom	NBEA WDFY4	2.25e-03	9	151	2	IPR000409
Domain	PAX	PAX2 PAX5	2.25e-03	9	151	2	PF00292
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CYP4V2 FUT10 PDE4D SGSM1 GALNT2 ATRX TMC6 PTDSS1 OBSCN FBXL17 CHD9 ARHGAP35 F7 DNAH14 PTK7 ITPKB PTPN4 KLHL9 TRNT1 PTPRB CSNK1A1 ZFHX2 PHF14 UTRN	9.26e-08	1489	160	24	28611215
Pubmed	Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development.	ETV5 NDST3 PAX2 MAPK3	1.97e-06	20	160	4	17107998
Pubmed	Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.	PTK7 CELSR2 NUP93 MAPK3 DYNC1H1	1.48e-05	67	160	5	21875946
Pubmed	HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.	F7 MYO3A UTRN DYNC1H1	1.80e-05	34	160	4	25925205
Pubmed	ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma.	ZDHHC11B ZDHHC11	2.10e-05	2	160	2	28331227
Pubmed	Interaction of the Flt-1 tyrosine kinase receptor with the p85 subunit of phosphatidylinositol 3-kinase. Mapping of a novel site involved in binding.	FLT1 PIK3R1	2.10e-05	2	160	2	7657594
Pubmed	Expression of a novel TGIF subclass homeobox gene, Tex1, in the spermatids of mouse testis during spermatogenesis.	TGIF2LY TGIF2LX	2.10e-05	2	160	2	11960710
Pubmed	Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization.	ITPKA ITPKB	2.10e-05	2	160	2	1330886
Pubmed	Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation.	SPEG RYR2	2.10e-05	2	160	2	32683896
Pubmed	Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice.	GRM1 MAPK3	2.10e-05	2	160	2	11356865
Pubmed	Uroporphyria in the uroporphyrinogen decarboxylase-deficient mouse: Interplay with siderosis and polychlorinated biphenyl exposure.	HFE UROD	2.10e-05	2	160	2	12297827
Pubmed	Molecular cloning and expression of a new putative inositol 1,4,5-trisphosphate 3-kinase isoenzyme.	ITPKA ITPKB	2.10e-05	2	160	2	1654894
Pubmed	Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes.	PDE4A PDE4D	2.10e-05	2	160	2	9520403
Pubmed	Genetic Causes of Liver Disease: When to Suspect a Genetic Etiology, Initial Lab Testing, and the Basics of Management.	HFE LIPA	2.10e-05	2	160	2	31582009
Pubmed	Diagnostic utility of PAX2 and PAX5 in distinguishing non-small cell lung cancer from small cell lung cancer.	PAX2 PAX5	2.10e-05	2	160	2	26823795
Pubmed	Testis-specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization.	ZDHHC11B ZDHHC11	2.10e-05	2	160	2	35384384
Pubmed	Co-inheritance of mutations in the uroporphyrinogen decarboxylase and hemochromatosis genes accelerates the onset of porphyria cutanea tarda.	HFE UROD	2.10e-05	2	160	2	11069625
Pubmed	Orthologous relationship of obscurin and Unc-89: phylogeny of a novel family of tandem myosin light chain kinases.	SPEG OBSCN	2.10e-05	2	160	2	15185077
Pubmed	Association of TGIFLX/Y mRNA expression with prostate cancer.	TGIF2LY TGIF2LX	2.10e-05	2	160	2	18663611
Pubmed	The human-specific Yp11.2/Xq21.3 homology block encodes a potentially functional testis-specific TGIF-like retroposon.	TGIF2LY TGIF2LX	2.10e-05	2	160	2	12226713
Pubmed	Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment.	FLT3 PAX5	2.10e-05	2	160	2	16618805
Pubmed	Identification of two promoters for human D-amino acid oxidase gene: implication for the differential promoter regulation mediated by PAX5/PAX2.	PAX2 PAX5	2.10e-05	2	160	2	25500505
Pubmed	Association of TGIFLX/Y mRNA expression with azoospermia in infertile men.	TGIF2LY TGIF2LX	2.10e-05	2	160	2	18384077
Pubmed	Cloning and expression in Escherichia coli of a rat brain cDNA encoding a Ca2+/calmodulin-sensitive inositol 1,4,5-trisphosphate 3-kinase.	ITPKA ITPKB	2.10e-05	2	160	2	2176078
Pubmed	System x(c)- activity and astrocytes are necessary for interleukin-1 beta-mediated hypoxic neuronal injury.	GRM1 IL1R1	2.10e-05	2	160	2	17881516
Pubmed	Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the midbrain-hindbrain boundary.	PAX2 PAX5	2.10e-05	2	160	2	10662641
Pubmed	Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit.	OBSCN PIK3R1	2.10e-05	2	160	2	27323778
Pubmed	Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation.	PIK3R1 IL1R1	2.10e-05	2	160	2	9360994
Pubmed	A mouse model of familial porphyria cutanea tarda.	HFE UROD	2.10e-05	2	160	2	11134514
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	ABCA3 ATP13A1 TMC6 PTDSS1 AKR1A1 GRM1 CRY2 PTOV1 SPATA2L AATK MRAP USP4 ZDHHC11	2.23e-05	697	160	13	28298427
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	PDE4D CSNK1A1 MAPK3 UTRN DYNC1H1	2.75e-05	76	160	5	27542412
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	VPS33A USP24 CHD9 MYEF2 PRPF4 NUP93 ASCC3 TP73	5.21e-05	282	160	8	23667531
Pubmed	Voltage-gated sodium channel Nav 1.7 promotes gastric cancer progression through MACC1-mediated upregulation of NHE1.	MACC1 SLC9A1	6.29e-05	3	160	2	27529686
Pubmed	β2-adrenergic receptor-coupled phosphoinositide 3-kinase constrains cAMP-dependent increases in cardiac inotropy through phosphodiesterase 4 activation.	PDE4D PIK3R1	6.29e-05	3	160	2	20705779
Pubmed	Role for ERK1/2-dependent activation of FCHSD2 in cancer cell-selective regulation of clathrin-mediated endocytosis.	FCHSD2 MAPK3	6.29e-05	3	160	2	30249660
Pubmed	Semaphorin3A elevates vascular permeability and contributes to cerebral ischemia-induced brain damage.	FLT1 SEMA3A	6.29e-05	3	160	2	25601765
Pubmed	Functional relevance of the stretch-dependent slow force response in failing human myocardium.	RYR2 SLC9A1	6.29e-05	3	160	2	15105296
Pubmed	Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias.	PDE4D RYR2	6.29e-05	3	160	2	16213210
Pubmed	MEN1 Degradation Induced by Neddylation and the CUL4B-DCAF7 Axis Promotes Pancreatic Neuroendocrine Tumor Progression.	CUL4B DCAF7	6.29e-05	3	160	2	36939378
Pubmed	ZDHHC19 localizes to the cell membrane of spermatids and is involved in spermatogenesis†.	ZDHHC11B ZDHHC11	6.29e-05	3	160	2	34897408
Pubmed	The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).	PDE4A PDE4D	6.29e-05	3	160	2	24555506
Pubmed	Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D.	PDE4A PDE4D	6.29e-05	3	160	2	17404263
Pubmed	Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages.	PDE4A PDE4D	6.29e-05	3	160	2	16034090
Pubmed	Angiotensin II Regulates Dendritic Cells through Activation of NF-κB /p65, ERK1/2 and STAT1 Pathways.	STAT1 MAPK3	6.29e-05	3	160	2	28723692
Pubmed	Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation.	PDE4A PDE4D	6.29e-05	3	160	2	15585880
Pubmed	MAPK3/1 participates in the activation of primordial follicles through mTORC1-KITL signaling.	KITLG MAPK3	6.29e-05	3	160	2	28218391
Pubmed	Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect.	PDE4A PDE4D	6.29e-05	3	160	2	10213096
Pubmed	PAX immunoreactivity in poorly differentiated small round cell tumors of childhood.	PAX2 PAX5	6.29e-05	3	160	2	24897005
Pubmed	Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem cell factor.	KITLG PIK3R1	6.29e-05	3	160	2	1379243
Pubmed	RYR2, PTDSS1 and AREG genes are implicated in a Lebanese population-based study of copy number variation in autism.	PTDSS1 RYR2	6.29e-05	3	160	2	26742492
Pubmed	Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts.	PDE4A PDE4D	6.29e-05	3	160	2	18508768
Pubmed	Pax-5 is expressed at the midbrain-hindbrain boundary during mouse development.	PAX2 PAX5	6.29e-05	3	160	2	1283313
Pubmed	Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit.	PIK3R1 IL1R1	6.29e-05	3	160	2	10373529
Pubmed	The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells.	ITPKA ITPKB	6.29e-05	3	160	2	12747803
Pubmed	ATP stimulates mouse embryonic stem cell proliferation via protein kinase C, phosphatidylinositol 3-kinase/Akt, and mitogen-activated protein kinase signaling pathways.	PIK3R1 MAPK3	6.29e-05	3	160	2	16916926
Pubmed	FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia.	FLT3 PIK3R1	6.29e-05	3	160	2	23246379
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	CUL4B PPP2R2D LONP2 AZGP1 F7 DIS3 KLHL20 SPATA2L KLHL9 PRPF4 POLR1B USP4 NUP93 ASCC3 UTRN	6.73e-05	1005	160	15	19615732
Pubmed	FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling.	ETV5 PAX2 MAPK3	7.41e-05	18	160	3	30853441
Pubmed	Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma.	FLT1 STAT1 PIK3R1 MAPK3	7.78e-05	49	160	4	23397142
Pubmed	Isthmin-1 (Ism1) modulates renal branching morphogenesis and mesenchyme condensation during early kidney development.	ETV5 PAX2 MAPK3	8.77e-05	19	160	3	37185772
Pubmed	Cryptochromes-Mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism.	CUL4B CRY2 DCAF7	1.03e-04	20	160	3	31155351
Pubmed	Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.	FLT1 FLT3 DSCAM SPEG OBSCN PTK7	1.09e-04	162	160	6	25826454
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	FLT1 SPEG TBC1D2B OBSCN CHD9 NBEA DYSF PTPRB ASCC3 DCAF7	1.09e-04	497	160	10	36774506
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	SMG1 VPS33A USP24 NBEA ARHGAP35 DIS3 STAT1 MYEF2 PPP2R2B CSNK1A1	1.11e-04	498	160	10	36634849
Pubmed	DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development.	DCAF15 MAPK3 DCAF7	1.20e-04	21	160	3	30111536
Pubmed	PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts.	STAT1 MAPK3	1.25e-04	4	160	2	26795953
Pubmed	Molecular cloning of a mouse scavenger receptor with C-type lectin (SRCL)(1), a novel member of the scavenger receptor family.	TGIF2LY TGIF2LX	1.25e-04	4	160	2	11718900
Pubmed	mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.	GRM1 MAPK3	1.25e-04	4	160	2	25181481
Pubmed	Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding.	PAX2 PAX5	1.25e-04	4	160	2	11134340
Pubmed	Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation.	GRM1 MAPK3	1.25e-04	4	160	2	20180987
Pubmed	Up-regulation of CD80-CD86 and IgA on mouse peritoneal B-1 cells by porin of Shigella dysenteriae is Toll-like receptors 2 and 6 dependent.	TLR6 CD80	1.25e-04	4	160	2	15482852
Pubmed	Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.	PDE4A PDE4D	1.25e-04	4	160	2	9371714
Pubmed	ZDHHC11 modulates innate immune response to DNA virus by mediating MITA-IRF3 association.	ZDHHC11B ZDHHC11	1.25e-04	4	160	2	29429998
Pubmed	Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice.	PDE4A PDE4D	1.25e-04	4	160	2	34943270
Pubmed	STAT1 regulates p73-mediated Bax gene expression.	STAT1 TP73	1.25e-04	4	160	2	17346710
Pubmed	CIAPIN1 Targeted NHE1 and ERK1/2 to Suppress NSCLC Cells' Metastasis and Predicted Good Prognosis in NSCLC Patients Receiving Pulmonectomy.	SLC9A1 MAPK3	1.25e-04	4	160	2	31093311
Pubmed	Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice.	PDE4A PDE4D	1.25e-04	4	160	2	21670503
Pubmed	PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.	PDE4A PDE4D	1.25e-04	4	160	2	32738081
Pubmed	A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.	PDE4A PDE4D	1.25e-04	4	160	2	8413254
Pubmed	Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes.	PDE4A PDE4D	1.25e-04	4	160	2	15644445
Pubmed	Soluble thrombopoietin receptor (Mpl) and granulocyte colony-stimulating factor receptor directly stimulate proliferation of primitive hematopoietic progenitors of mice in synergy with steel factor or the ligand for Flt3/Flk2.	FLT3 KITLG	1.25e-04	4	160	2	8943846
Pubmed	Proteins implicated in muscular dystrophy and cancer are functional constituents of the centrosome.	DYSF UTRN	1.25e-04	4	160	2	35790299
Pubmed	Kit ligand and Il7 differentially regulate Peyer's patch and lymph node development.	PTK7 KITLG	1.25e-04	4	160	2	20709954
Pubmed	Vascular endothelial growth factor receptor 1 contributes to Escherichia coli K1 invasion of human brain microvascular endothelial cells through the phosphatidylinositol 3-kinase/Akt signaling pathway.	FLT1 PIK3R1	1.25e-04	4	160	2	20805333
Pubmed	mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module.	PDE4A PDE4D	1.25e-04	4	160	2	11296225
Pubmed	Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion.	PDE4A PDE4D	1.25e-04	4	160	2	22946044
Pubmed	B cell receptor-ERK1/2 signal cancels PAX5-dependent repression of BLIMP1 through PAX5 phosphorylation: a mechanism of antigen-triggering plasma cell differentiation.	PAX5 MAPK3	1.25e-04	4	160	2	22593617
Pubmed	Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice.	PDE4A PDE4D	1.25e-04	4	160	2	33609559
Pubmed	Regulation of alveolar epithelial Na+ channels by ERK1/2 in chlorine-breathing mice.	SCNN1G MAPK3	1.25e-04	4	160	2	21997487
Pubmed	Phosphorylation of human insulin receptor substrate-1 at Serine 629 plays a positive role in insulin signaling.	PIK3R1 MAPK3	1.25e-04	4	160	2	17640984
Pubmed	Proximity Labeling, Quantitative Proteomics, and Biochemical Studies Revealed the Molecular Mechanism for the Inhibitory Effect of Indisulam on the Proliferation of Gastric Cancer Cells.	CUL4B DCAF15	1.25e-04	4	160	2	34420308
Pubmed	Humanised antihuman IL-6R antibody with interferon inhibits renal cell carcinoma cell growth in vitro and in vivo through suppressed SOCS3 expression.	STAT1 MAPK3	1.25e-04	4	160	2	23274199
Pubmed	Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine.	PDE4A PDE4D	1.25e-04	4	160	2	24732776
Pubmed	Altered chondrocyte differentiation, matrix mineralization and MEK-Erk1/2 signaling in an INPPL1 catalytic knock-out mouse model of opsismodysplasia.	INPPL1 MAPK3	1.25e-04	4	160	2	31519471
Pubmed	p73 Interacts with c-Myc to regulate Y-box-binding protein-1 expression.	DENND4A TP73	1.25e-04	4	160	2	12080043
Pubmed	Stem cell factor/c-kit receptor signaling enhances the proliferation and invasion of colorectal cancer cells through the PI3K/Akt pathway.	KITLG MAPK3	1.25e-04	4	160	2	17410437
Pubmed	Transcription factor p73 regulates Th1 differentiation.	STAT1 TP73	1.25e-04	4	160	2	32193462
Pubmed	Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development.	PAX2 PAX5	1.25e-04	4	160	2	10934015
Pubmed	Fibroblast growth factor 2-induced cytoplasmic asparaginyl-tRNA synthetase promotes survival of osteoblasts by regulating anti-apoptotic PI3K/Akt signaling.	NARS1 PIK3R1	1.25e-04	4	160	2	19631775
Pubmed	Phosphorylation/dephosphorylation of human SULT4A1: role of Erk1 and PP2A.	PPP2R2B MAPK3	1.25e-04	4	160	2	20920535
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	FLT1 FLT3 PTK7 AATK	1.15e-04	40	114	4	321
GeneFamily	WD repeat domain containing	PPP2R2D NBEA WDFY4 PPP2R2B TBC1D31 PRPF4 WDR87 DCAF7	2.56e-04	262	114	8	362
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	FLT1 DSCAM SPEG OBSCN PTK7 IL1R1	5.49e-04	161	114	6	593
GeneFamily	TALE class homeoboxes and pseudogenes	TGIF2LY MKX TGIF2LX	5.71e-04	26	114	3	526
GeneFamily	Transmembrane channel likes	TMC1 TMC6	1.08e-03	8	114	2	1135
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEA WDFY4	1.38e-03	9	114	2	1230
GeneFamily	Paired boxes	PAX2 PAX5	1.38e-03	9	114	2	675
GeneFamily	Immunoglobulin like domain containing	FLT1 FLT3 DSCAM PTK7 SEMA3A IL1R1	1.41e-03	193	114	6	594
GeneFamily	X-linked mental retardation\|RNA helicases	ATRX ASCC3	2.09e-03	11	114	2	1168
GeneFamily	Kelch like\|BTB domain containing	KLHL20 KLHL38 KLHL9	2.34e-03	42	114	3	617
GeneFamily	SH2 domain containing	INPPL1 STAT1 PIK3R1 CLNK	3.83e-03	101	114	4	741
GeneFamily	WD repeat domain containing\|Protein phosphatase 2 regulatory subunits	PPP2R2D PPP2R2B	3.92e-03	15	114	2	696
GeneFamily	Dyneins, axonemal	DNAH14 DNAH8	5.04e-03	17	114	2	536
GeneFamily	WD repeat domain containing\|DDB1 and CUL4 associated factors	DCAF15 DCAF7	5.64e-03	18	114	2	498
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 ATRX STAT1 ITPKB PTPRB KITLG ASCC3 UTRN	2.87e-07	178	161	8	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZDHHC11B KCNH7 PDE4D F7 SLC9A1 KITLG SCNN1G	9.16e-07	143	161	7	990844ca674d30b2924c74b45bed4fdfb8463fa7
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	DENND4A GALNT2 CHD9 DGKD WDFY4 FCHSD2 PAX5	2.20e-06	163	161	7	6bed27d2f67a430a847da5eb47878d14b4949c45
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZDHHC11B KCNH7 SGSM1 USP24 CACHD1 ITPKB FMN1	3.26e-06	173	161	7	4bc6d93716f093b460c8b047199db8cab5fea720
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 PDE4D USP24 CACHD1 ITPKB KITLG FMN1	4.08e-06	179	161	7	666072c0e8448dbaec1683d18368ec2502453f90
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZDHHC11B KCNH7 SGSM1 USP24 CACHD1 ITPKB FMN1	4.39e-06	181	161	7	e0abf2707d9e0aa942c657eef7d2cbcd02f060dd
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_3\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	RPLP0 ETV5 LRRTM3 SEMA3A VASH2 IL1R1 ADAMTSL2	4.72e-06	183	161	7	f4ea7113ce9099222743d9ff02388d3d8a9e987b
ToppCell	CTRL-Lymphoid-B_cell\|Lymphoid / Disease state, Lineage and Cell class	MACC1 ARHGAP24 PDE4D DGKD WDFY4 FCHSD2 PAX5	5.84e-06	189	161	7	14f3a8c0f4f057ad4e6839b4c3eeaf956d6dc92e
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	PDE4D OBSCN DGKD LRRTM3 RYR2 ST3GAL6 DDX60L	6.04e-06	190	161	7	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 ZIC3 PTPRB KITLG ST3GAL6 UTRN ADAMTSL2	6.47e-06	192	161	7	9ae05db5bfb8b9d3935c0328e6f2d489d2b1ebfd
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 ZIC3 PTPRB KITLG ST3GAL6 UTRN ADAMTSL2	6.47e-06	192	161	7	a116db7dec495e5a0ba9c7537057cd1e567d7885
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 ZIC3 PTPRB KITLG ST3GAL6 UTRN ADAMTSL2	6.47e-06	192	161	7	66defad13bd8e79319741e43ddb056841710b1d7
ToppCell	CF-Lymphoid-B_cell\|Lymphoid / Disease state, Lineage and Cell class	MACC1 DENND4A ARHGAP24 WDFY4 CD80 PAX5 DNAH8	6.69e-06	193	161	7	7ebf20344a9a154fd2cffa281526867fcf0aded3
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DENND4A GALNT2 CHD9 DGKD WDFY4 FCHSD2 PAX5	6.92e-06	194	161	7	d852aebf7a763b9a776c4570711f0c759f591910
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ARHGAP24 USP24 PTDSS1 WDFY4 CD80 PAX5 DNAH8	7.16e-06	195	161	7	a4d36654b968acb1aea252ac203683939461f1d1
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B-B_cell-B_mature\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP24 WDFY4 FCHSD2 CD80 PAX5 CLNK DNAH8	7.16e-06	195	161	7	3311a1bf4ed94820b45047d44fc14b14ac72e6fb
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ARHGAP24 USP24 PTDSS1 WDFY4 CD80 PAX5 DNAH8	7.16e-06	195	161	7	cd811abd949ef201aef1c8515da5575ab1b1cfea
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 USP24 CACHD1 ITPKB KITLG FMN1 PIK3R1	7.16e-06	195	161	7	a38d9dc6192aea673d96fda6b25e81223fda3abf
ToppCell	severe-B_memory\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ARHGAP24 WDFY4 FCHSD2 CD80 PAX5 CLNK DNAH8	8.17e-06	199	161	7	6d3436dd65d525aaa23ec02672005380f21c4d0f
ToppCell	mLN-Macrophage-LYVE1_Macrophage\|Macrophage / Region, Cell class and subclass	PDE4A ATP13A1 DGKD STAT1 FMN1 DYNC1H1 DCAF7	8.45e-06	200	161	7	e3c15e0e1c2602b0cc9ab8cc50c978d265350c94
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 ATRX STAT1 PIK3R1 DDX60L UTRN DYNC1H1	8.45e-06	200	161	7	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	mild-B_intermediate\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DENND4A ARHGAP24 WDFY4 FCHSD2 CD80 PAX5 DNAH8	8.45e-06	200	161	7	fe815824e9e4be3f3db73610e3814a7fd533da65
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_ALM_Macc1_Lrg1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CERKL MACC1 TMC1 KCNH4 ITPKA KITLG	1.31e-05	142	161	6	d08e1880425d285c4433014fe0242ac7ff7734af
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac1_Htr1d\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	FLT3 SEMA3A NDST3 ST3GAL6 MKX MAPK3	2.15e-05	155	161	6	79264ff283e36a059040a5aa9fe7337be694cb52
ToppCell	Fetal_29-31_weeks-Immune-dendritic_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FLT3 TMC6 WDFY4 FCHSD2 CD80 CLNK	2.15e-05	155	161	6	9f937ae48767fdcf1a944af4de0530d9c0ab441d
ToppCell	356C-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SMG1 ARHGAP24 AZGP1 MAGEE2 RYR2 KITLG	2.57e-05	160	161	6	0293b244c063a62819690bf22bbc2681f8d15252
ToppCell	356C-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SMG1 ARHGAP24 AZGP1 MAGEE2 RYR2 KITLG	2.57e-05	160	161	6	3eaae86fa08f7651021316f8e5811bf48055591e
ToppCell	mild_COVID-19_(asymptomatic)-B_intermediate\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	MACC1 ARHGAP24 WDFY4 CD80 PAX5 DNAH8	3.16e-05	166	161	6	8de8f388f24436b84e19ef460476fdbda4d16abf
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 TMC6 F7 C3orf20 PTPRB KITLG	3.50e-05	169	161	6	4126b20df9e85f028807482a51e20a300faa74c2
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c2-CXCR4(low)\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	DCAF15 NPFFR2 SLC22A9 SCNN1G DCAF7	3.64e-05	103	161	5	1b2edf25d6b845e7c07470b2a034654d63917c01
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	DENND4A CHD9 DGKD WDFY4 FCHSD2 PAX5	3.99e-05	173	161	6	d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCell	RV-03._Atrial_Cardiomyocyte\|RV / Chamber and Cluster_Paper	OBSCN LRRTM3 RYR2 SPACA1 PAX2	3.99e-05	105	161	5	49e16b11f16e83a7d17d162c14bce991201bcc2a
ToppCell	Control-B_cells-B_cells\|Control / group, cell type (main and fine annotations)	ARHGAP24 WDFY4 FCHSD2 PAX5 CLNK DNAH8	4.39e-05	176	161	6	d2c353783bd78dc24f28e00d917b88d8294fb5df
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ABCA3 PPP2R2D FCSK LIN37 VASH2 POLR1B	4.53e-05	177	161	6	36b5d29caa9cffbc0284f771a4db71aa72171a89
ToppCell	COVID-19-B_cells-Activated_B_cells\|COVID-19 / group, cell type (main and fine annotations)	ARHGAP24 WDFY4 FCHSD2 PAX5 CLNK DNAH8	4.53e-05	177	161	6	653bb62a3744d4024ab3186ee01d410ed62832a6
ToppCell	3'-Adult-Appendix-Hematopoietic-Plasma_cells-IgA_plasma_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA3 WDFY4 FCHSD2 LIPA TBC1D31 ST3GAL6	4.82e-05	179	161	6	2285e3a9018a60d7f6e974fee46b6f61d39aa76f
ToppCell	3'-Adult-Appendix-Hematopoietic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA3 WDFY4 FCHSD2 LIPA TBC1D31 ST3GAL6	4.82e-05	179	161	6	0b0f27d7c5cc5ae7618d887dcfa7219df8ff1935
ToppCell	3'-Adult-Appendix-Hematopoietic-Plasma_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA3 WDFY4 FCHSD2 LIPA TBC1D31 ST3GAL6	4.82e-05	179	161	6	63bc819df62b1f8f37bf1f17bdd4fcc161886923
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ABCA3 PPP2R2D FCSK LIN37 VASH2 POLR1B	4.97e-05	180	161	6	a682a5d55c612709c9ee9fa4289d6f8bef7fe1af
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_B-Branch_B2_(eMN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PIRT DSCAM MAP6 KCNH4 PPP2R2B ZFHX2	4.97e-05	180	161	6	368ff7fcfd21ad248f96a83a8b191040ba7d8670
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	OBSCN DGKD LRRTM3 RYR2 ST3GAL6 DDX60L	5.29e-05	182	161	6	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 KCNH7 USP24 CACHD1 KITLG FMN1	5.29e-05	182	161	6	5f513bbb7125956eb528e3120de3fd776770a7c3
ToppCell	E16.5-samps-Endothelial-Immature_fetal_endothelial-Intermediate_Endothelial\|E16.5-samps / Age Group, Lineage, Cell class and subclass	FLT1 DYSF RYR2 ITPKB PTPRB MAP4K5	5.29e-05	182	161	6	fec1caf867b1dc87b24504d895ee1a27df78062e
ToppCell	B_cells-ISG-high_B_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	WDFY4 STAT1 FCHSD2 DDX60L PAX5 DNAH8	5.45e-05	183	161	6	dc2b00e920efa1dcc2a6265cd1024e3249c9974f
ToppCell	3'_v3-blood-Lymphocytic_B-Memory_B_cells\|blood / Manually curated celltypes from each tissue	ARHGAP24 WDFY4 CD80 PAX5 CLNK DNAH8	5.45e-05	183	161	6	e3a418b745d7f040adf47be9e1043b945cae47ed
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 USP24 CACHD1 ITPKB KITLG FMN1	5.45e-05	183	161	6	2e831a4d99c6f983793df71c0994124c943c6da9
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DENND4A ARHGAP24 TLR6 FCHSD2 PAX5 CLNK	5.96e-05	186	161	6	1a1e5d85a5ad90afee234c12a9b54a5e93a8a2f2
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DENND4A ARHGAP24 TLR6 FCHSD2 PAX5 CLNK	5.96e-05	186	161	6	f1366638edaecad5cad6367440f4c693513bed7e
ToppCell	3'_v3-blood-Lymphocytic_B\|blood / Manually curated celltypes from each tissue	ARHGAP24 WDFY4 CD80 PAX5 CLNK DNAH8	5.96e-05	186	161	6	5624b1fc7eab9f505588fcc86a24d14f8bcbfef7
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MACC1 ABCA3 ARHGAP24 MYO3A SCNN1G UTRN	5.96e-05	186	161	6	4e94158db52df41d71e67b02b9895a358eebee0f
ToppCell	droplet-Heart-nan-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 ATRX ITPKB PTPRB KITLG UTRN	5.96e-05	186	161	6	0ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCell	pdx-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	PDE4D TMC6 DGKD CACHD1 FMN1 PAX2	6.14e-05	187	161	6	7e376831a11ee72ed87abcdac631ca46ae29c250
ToppCell	COPD-Epithelial-ATII\|Epithelial / Disease state, Lineage and Cell class	ABCA3 PDE4D ETV5 DGKD SLC9A1 AATK	6.14e-05	187	161	6	030af361f8bdcd0aff4ec1922702833325cf74d8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 SGSM1 USP24 CACHD1 ITPKB FMN1	6.33e-05	188	161	6	bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 SGSM1 USP24 CACHD1 ITPKB FMN1	6.33e-05	188	161	6	eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MACC1 ABCA3 ARHGAP24 ETV5 FMN1 CLNK	6.33e-05	188	161	6	4bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MACC1 PDE4D KITLG SCNN1G PAX2 CLNK	6.33e-05	188	161	6	58ccb31cdf43167872ef0fc737e6f9c51ee2e060
ToppCell	COVID-19_Severe-pDC\|World / disease group, cell group and cell class	FLT3 GALNT2 WDFY4 PTK7 FCHSD2 VASH2	6.33e-05	188	161	6	4c8e328b8206120708b05ea3c5865a0200dc5c4e
ToppCell	COPD-Myeloid-cMonocyte\|Myeloid / Disease state, Lineage and Cell class	FLT1 PDE4A PDE4D DYSF FMN1 IL1R1	6.52e-05	189	161	6	6294691231c7d38707323cf31578a107d3b2c622
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 USP24 CACHD1 ITPKB KITLG FMN1	6.52e-05	189	161	6	975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ARHGAP24 GALNT2 WDFY4 FCHSD2 CD80 PAX5	6.52e-05	189	161	6	886dceacf96e2b6750c146a381da0bf96a2bb15b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 USP24 CACHD1 ITPKB KITLG FMN1	6.52e-05	189	161	6	7eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ARHGAP24 GALNT2 WDFY4 FCHSD2 CD80 PAX5	6.52e-05	189	161	6	5f1f4321939877374a8ee13de93f2d1390af8e2e
ToppCell	CF-Lymphoid-B_cell\|CF / Disease state, Lineage and Cell class	ARHGAP24 WDFY4 MYEF2 CD80 PAX5 DNAH8	6.71e-05	190	161	6	374d8fd63c733178acab07682ed1519693efab45
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.4.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRAV12-1 DGKD PTPN4 PPP2R2B PIK3R1 UTRN	6.71e-05	190	161	6	d153a0bdedcd6865e6ee19575234a78b5d859ff1
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 SGSM1 USP24 ITPKB PTPN4 FMN1	6.71e-05	190	161	6	b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 SGSM1 USP24 ITPKB KITLG FMN1	6.71e-05	190	161	6	e252e925600e6457fa6e362a55217f4cffa75cdb
ToppCell	facs-Heart-LA-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DYSF ITPKB PTPRB KITLG UTRN	6.91e-05	191	161	6	a15f0fb4bd7dd77ef5f931b6fc9d68697deec1d1
ToppCell	COPD-Myeloid-cDC2\|COPD / Disease state, Lineage and Cell class	FLT1 FLT3 PDE4A CD80 FMN1 IL1R1	6.91e-05	191	161	6	2af6e4a6bd1f2193ece2131c3b7d976dd23a6966
ToppCell	facs-Heart-LA-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DYSF ITPKB PTPRB KITLG UTRN	6.91e-05	191	161	6	827be47d3574c6c5b021c6f1c1670834344f10cb
ToppCell	Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|World / Lineage, Cell type, age group and donor	MACC1 PDE4D DSCAM CACHD1 DNAH14 CELSR2	6.91e-05	191	161	6	d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MACC1 PDE4D STAT1 KITLG CELSR2 SCNN1G	7.11e-05	192	161	6	9e031bf93eb8757fdd0cc22f01b44e48f85532d5
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	RPLP0 ETV5 SEMA3A NDST3 IL1R1 ADAMTSL2	7.11e-05	192	161	6	4c9d748f209cc1e13d28c8c7f5180ab8522e0fbf
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	RPLP0 ETV5 SEMA3A NDST3 IL1R1 ADAMTSL2	7.11e-05	192	161	6	c4efc170852abbcf0c53c2b0f8a0cc9fe7f116c8
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ABCA3 PDE4D ETV5 CACHD1 DNAH14 FMN1	7.11e-05	192	161	6	fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCell	moderate-Lymphoid-B_cell\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ARHGAP24 TLR6 WDFY4 FCHSD2 PAX5 DNAH8	7.11e-05	192	161	6	ae3727503c3b9f4695e565fd3161cc33b898f349
ToppCell	control-Lymphoid-CTL\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	TBC1D2B NARS1 STAT1 PPP2R2B PIK3R1 UTRN	7.31e-05	193	161	6	89d407a88b5956559a589425b89b3eb8dc78e1dd
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNH7 GRM1 RYR2 KCNH4 ITPKA CELSR2	7.31e-05	193	161	6	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 ZIC3 PTPRB KITLG ST3GAL6 UTRN	7.31e-05	193	161	6	e4b440d50ae7391b26924778be6d9d53e0692449
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 ZIC3 PTPRB KITLG ST3GAL6 UTRN	7.31e-05	193	161	6	e523dc5751f6fdcd4fc1a62b1eecd43f6ae79da9
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	CUL4B ATRX POLR1B UTRN DYNC1H1 DCAF7	7.31e-05	193	161	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	mild_COVID-19_(asymptomatic)-CD4+_Tcm\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	TNFRSF25 PDE4D RPLP0 ITPKB FMN1 PIK3R1	7.31e-05	193	161	6	498d3a83bce6deff69aea71b18a43688e0a8ed7d
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 TNFRSF25 USP24 C3orf20 ZDHHC11 UTRN	7.31e-05	193	161	6	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 ZIC3 PTPRB KITLG ST3GAL6 UTRN	7.31e-05	193	161	6	1772f2ac217727de63c4a9303881b3a19a6bb0f0
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNH7 GRM1 RYR2 KCNH4 ITPKA CELSR2	7.31e-05	193	161	6	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ARHGAP24 PDE4D WDFY4 CD80 PAX5 DNAH8	7.31e-05	193	161	6	de0213f2105b814f38ffbfd004ea7603230eed68
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNH7 GRM1 RYR2 KCNH4 ITPKA CELSR2	7.31e-05	193	161	6	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	COVID-19_Mild-Lymphoid_B-B_intermediate\|COVID-19_Mild / Disease group, lineage and cell class	ARHGAP24 WDFY4 FCHSD2 CD80 PAX5 DNAH8	7.53e-05	194	161	6	bf6f72a489c62cbf1a679552d8c5eaaaa0b99d33
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MACC1 PDE4D NBEA PPP2R2B KITLG SCNN1G	7.53e-05	194	161	6	4579b4a44f7c731553a284843c296866027d7c0e
ToppCell	droplet-Limb_Muscle-MUSCLE\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 ATRX PTPRB KITLG ASCC3 UTRN	7.53e-05	194	161	6	e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 CACHD1 DYSF RYR2 PTPRB UTRN	7.53e-05	194	161	6	a429d22c8c9d0fd3bfa9f877a6364cecad68db30
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-B_lymphocytic-memory_B_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ARHGAP24 TLR6 WDFY4 FCHSD2 PAX5 CLNK	7.53e-05	194	161	6	f0c113edb706d53792892115b67277a285219942
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DENND4A ARHGAP24 CHD9 DGKD WDFY4 PAX5	7.74e-05	195	161	6	481989d2e5bd2582da3d86b0155c4d6615317067
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DENND4A ARHGAP24 CHD9 DGKD WDFY4 PAX5	7.74e-05	195	161	6	6108a27523d1b93a7fbe35cb95704a5ad9071e3c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	USP24 CACHD1 ITPKB KITLG FMN1 PIK3R1	7.74e-05	195	161	6	60d08fb27469d1e247bc47b651d7023ba82cf92f
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MACC1 PDE4D NBEA PPP2R2B KITLG SCNN1G	7.74e-05	195	161	6	3d6d3de8ada6dce3dc789c15b50cc066e7100496
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PDE4D USP24 PTDSS1 CD80 PAX5 DNAH8	7.96e-05	196	161	6	fd756b247b2d8a291e8e71bec6f1e463d6557536
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-IPC/newborn-38\|World / Primary Cells by Cluster	RPLP0 ATRX CHD9 PPP2R2B CELSR2 PHF14	7.96e-05	196	161	6	38da0751941adca650fe9b383d9f343153978eb5
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-IPC/newborn\|World / Primary Cells by Cluster	RPLP0 ATRX CHD9 PPP2R2B CELSR2 PHF14	7.96e-05	196	161	6	721650a08d260faf530dbd52d4e9275d27f3bac2
ToppCell	moderate-Lymphoid-Treg\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SMG1 TNFRSF25 PDE4D TMC6 TBC1D31 IL1R1	7.96e-05	196	161	6	9152f4a8a27ff4ee28f231c5ad00eb2edd9ea6da
Disease	Down syndrome (biomarker_via_orthology)	RPLP0 RPLP0P6	2.71e-05	2	154	2	DOID:14250 (biomarker_via_orthology)
Disease	lung adenocarcinoma (is_marker_for)	ATRX AZGP1 AKR1A1 PTPRB PIK3R1	8.50e-05	85	154	5	DOID:3910 (is_marker_for)
Disease	Vitiligo	CD80 PIK3R1 CLNK	8.98e-05	17	154	3	C0042900
Disease	Porphyria Cutanea Tarda	HFE UROD	1.61e-04	4	154	2	C0162566
Disease	phospholipids in medium HDL measurement	GALNT2 MOGAT2 CELSR2 MAP4K5	1.98e-04	55	154	4	EFO_0022295
Disease	total lipids in medium HDL measurement	GALNT2 MOGAT2 CELSR2 MAP4K5	2.43e-04	58	154	4	EFO_0022310
Disease	cholesterol in medium HDL measurement	GALNT2 MOGAT2 CELSR2 MAP4K5	2.60e-04	59	154	4	EFO_0021903
Disease	insulin-like growth factor-binding protein 1 measurement	CELSR2 MAP4K5	2.68e-04	5	154	2	EFO_0020474
Disease	free cholesterol to total lipids in medium HDL percentage	GALNT2 MOGAT2 CELSR2 NUP93	2.77e-04	60	154	4	EFO_0022282
Disease	phospholipids in HDL measurement	GALNT2 MOGAT2 CELSR2 MAP4K5	2.95e-04	61	154	4	EFO_0022293
Disease	porphyria cutanea tarda (is_implicated_in)	HFE UROD	4.00e-04	6	154	2	DOID:3132 (is_implicated_in)
Disease	lung small cell carcinoma (is_implicated_in)	ATRX PIK3R1 TP73	4.15e-04	28	154	3	DOID:5409 (is_implicated_in)
Disease	NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE	ARHGAP24 PAX2 NUP93	5.10e-04	30	154	3	C1868672
Disease	neuropilin-1 measurement	GALNT2 MAP4K5	5.59e-04	7	154	2	EFO_0020603
Disease	endometrial adenocarcinoma (is_implicated_in)	PIK3R1 MAPK3	5.59e-04	7	154	2	DOID:2870 (is_implicated_in)
Disease	group XIIB secretory phospholipase A2-like protein measurement	CELSR2 MAP4K5	5.59e-04	7	154	2	EFO_0801657
Disease	Ovarian Mucinous Adenocarcinoma	SPEG MYO3A AATK	5.63e-04	31	154	3	C1335167
Disease	albumin:globulin ratio measurement	GALNT2 FCHSD2 MAP4K5 IL1R1	5.87e-04	73	154	4	EFO_0005128
Disease	choline measurement	GALNT2 MOGAT2 CELSR2 MAP4K5 NUP93	6.15e-04	130	154	5	EFO_0010116
Disease	age of onset of Alzheimer disease	DSCAM FMN1 PHF14	6.78e-04	33	154	3	OBA_2001000
Disease	nephroblastoma (is_marker_for)	FLT1 STAT1 PAX2	7.41e-04	34	154	3	DOID:2154 (is_marker_for)
Disease	Burkitt Lymphoma	FLT3 PIK3R1 PAX5	8.77e-04	36	154	3	C0006413
Disease	very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio	GALNT2 MOGAT2 USP24 CELSR2 MAP4K5 NUP93	1.13e-03	222	154	6	EFO_0008317, EFO_0020943
Disease	estrogen measurement	CRY2 SLC22A9	1.18e-03	10	154	2	EFO_0011007
Disease	autism spectrum disorder (implicated_via_orthology)	ABCA3 DSCAM CHD9 NBEA NDST3	1.24e-03	152	154	5	DOID:0060041 (implicated_via_orthology)
Disease	phospholipids:total lipids ratio	GALNT2 MOGAT2 USP24 CELSR2 MAP4K5 NUP93	1.27e-03	227	154	6	EFO_0020946
Disease	eye color	PDE4D FBXL17 ITPKB VASH2	1.29e-03	90	154	4	EFO_0003949
Disease	fibrinogen measurement, coronary artery disease	FLT1 CHD9 LIPA CELSR2 IL1R1	1.31e-03	154	154	5	EFO_0001645, EFO_0004623
Disease	triglycerides in large LDL measurement	GALNT2 CELSR2 MAP4K5	1.48e-03	43	154	3	EFO_0022319
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	PPP2R2D PPP2R2B	1.73e-03	12	154	2	DOID:1441 (implicated_via_orthology)
Disease	level of Diacylglycerol (18:1_18:2) in blood serum	GALNT2 MAP4K5	1.73e-03	12	154	2	OBA_2045171
Disease	thyroid gland carcinoma (is_marker_for)	FLT1 PTPRB	1.73e-03	12	154	2	DOID:3963 (is_marker_for)
Disease	phosphoglycerides measurement	MOGAT2 MAP4K5 NUP93	2.03e-03	48	154	3	EFO_0022291
Disease	serum alanine aminotransferase measurement	HFE FLT1 ARHGEF19 NARS1 FBXL17 ETV5 FCSK CELSR2 TRMT44 MAP4K5 PIK3R1 IL1R1	2.08e-03	869	154	12	EFO_0004735
Disease	Retinitis Pigmentosa	CYP4V2 CERKL CHM PRPF4	2.19e-03	104	154	4	C0035334
Disease	Mental Depression	DAOA PDE4A PDE4D GRM1 CRY2 MAPK3	2.23e-03	254	154	6	C0011570
Disease	triglycerides to total lipids in medium LDL percentage	GALNT2 CELSR2 MAP4K5	2.28e-03	50	154	3	EFO_0022334
Disease	CD209 antigen measurement	CELSR2 ADAMTSL2	2.36e-03	14	154	2	EFO_0008077
Disease	triglycerides to total lipids in large LDL percentage	GALNT2 CELSR2 MAP4K5	2.42e-03	51	154	3	EFO_0022331
Disease	fibrinogen measurement	GALNT2 CHD9 LIPA IL1R1	2.60e-03	109	154	4	EFO_0004623
Disease	total phospholipids in lipoprotein particles measurement	MOGAT2 CELSR2 MAP4K5	2.70e-03	53	154	3	EFO_0022315
Disease	free cholesterol to total lipids in small LDL percentage	GALNT2 CELSR2 MAP4K5	2.70e-03	53	154	3	EFO_0022286
Disease	very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	GALNT2 MOGAT2 USP24 CELSR2 MAP4K5 NUP93	2.70e-03	264	154	6	EFO_0008317, EFO_0020944
Disease	diffuse idiopathic skeletal hyperostosis	HAO1 PIK3R1	2.72e-03	15	154	2	EFO_0007236
Disease	triacylglycerol 52:3 measurement	GALNT2 MAP4K5	2.72e-03	15	154	2	EFO_0010415
Disease	total lipids in medium VLDL	GALNT2 CELSR2 MAP4K5	2.85e-03	54	154	3	EFO_0022153
Disease	linoleic acid measurement	C22orf42 MOGAT2 CELSR2 MAP4K5 MRAP	2.99e-03	186	154	5	EFO_0006807
Disease	triglycerides in medium VLDL measurement	GALNT2 CELSR2 MAP4K5	3.00e-03	55	154	3	EFO_0022155
Disease	cholesterol to total lipids in large HDL percentage	CELSR2 MAP4K5 NUP93	3.00e-03	55	154	3	EFO_0022234
Disease	acute lymphoblastic leukemia (is_implicated_in)	HFE FLT3 PAX5	3.00e-03	55	154	3	DOID:9952 (is_implicated_in)
Disease	low density lipoprotein cholesterol measurement, lipid measurement	HFE GALNT2 CELSR2 MAP4K5	3.05e-03	114	154	4	EFO_0004529, EFO_0004611
Disease	total cholesterol measurement, low density lipoprotein cholesterol measurement	HFE GALNT2 CELSR2 MAP4K5	3.05e-03	114	154	4	EFO_0004574, EFO_0004611
Disease	amino acid measurement	PDE4D GALNT2 PTDSS1 GRM1 RYR2 NDST3 NBAS PTPRB FMN1 MAP4K5	3.06e-03	678	154	10	EFO_0005134
Disease	liver fat measurement, liver disease biomarker	HFE MAP4K5	3.10e-03	16	154	2	EFO_0006845, EFO_0010821
Disease	Spondyloepiphyseal Dysplasia	FLT1 ADAMTSL2	3.10e-03	16	154	2	C0038015
Disease	Spondyloepiphyseal Dysplasia Tarda, X-Linked	FLT1 ADAMTSL2	3.10e-03	16	154	2	C3541456
Disease	Schwartz-Jampel Syndrome, Type 1	FLT1 ADAMTSL2	3.10e-03	16	154	2	C4551479
Disease	Seasonal Affective Disorder	PDE4A CRY2	3.10e-03	16	154	2	C0085159
Disease	Schwartz-Jampel Syndrome	FLT1 ADAMTSL2	3.10e-03	16	154	2	C0036391
Disease	Melnick-Needles Syndrome	FLT1 ADAMTSL2	3.10e-03	16	154	2	C0025237
Disease	serum gamma-glutamyl transferase measurement	ARHGEF19 SGSM1 ATRX NARS1 CHD9 ADAM30 ARHGAP35 RYR2 CELSR2 MAP4K5 PIK3R1 PAX2	3.14e-03	914	154	12	EFO_0004532
Disease	triglycerides in LDL measurement	GALNT2 CELSR2 MAP4K5	3.16e-03	56	154	3	EFO_0022320
Disease	cholesterol to total lipids in large LDL percentage	CELSR2 MAP4K5 NUP93	3.16e-03	56	154	3	EFO_0022235
Disease	Hypertrophic Cardiomyopathy	OBSCN RYR2 SLC9A1	3.32e-03	57	154	3	C0007194
Disease	triglycerides in IDL measurement	GALNT2 CELSR2 MAP4K5	3.49e-03	58	154	3	EFO_0022149
Disease	free cholesterol in medium HDL measurement	GALNT2 MOGAT2 MAP4K5	3.49e-03	58	154	3	EFO_0022267
Disease	IGF-1 measurement, IGFBP-3 measurement	CELSR2 MAP4K5	3.50e-03	17	154	2	EFO_0004626, EFO_0004627
Disease	Van Buchem disease	FLT1 ADAMTSL2	3.50e-03	17	154	2	C0432272
Disease	triglycerides to total lipids in small LDL percentage	GALNT2 CELSR2 MAP4K5	3.66e-03	59	154	3	EFO_0022337
Disease	phospholipids in VLDL measurement	GALNT2 CELSR2 MAP4K5	3.66e-03	59	154	3	EFO_0022301
Disease	cholesteryl esters to total lipids in large HDL percentage	CELSR2 MAP4K5 NUP93	3.66e-03	59	154	3	EFO_0022248
Disease	phospholipids in small LDL measurement	GALNT2 CELSR2 MAP4K5	3.66e-03	59	154	3	EFO_0022297
Disease	low density lipoprotein cholesterol measurement, phospholipid measurement	HFE GALNT2 CELSR2 MAP4K5	3.67e-03	120	154	4	EFO_0004611, EFO_0004639
Disease	cholesterol:total lipids ratio, intermediate density lipoprotein measurement	GALNT2 MOGAT2 CELSR2 MAP4K5	3.78e-03	121	154	4	EFO_0008595, EFO_0020943
Disease	neuropsychological test	FLT1 PPP2R2B MAP4K5 TGIF2LX DSEL	3.82e-03	197	154	5	EFO_0003926
Disease	total lipids in VLDL measurement	GALNT2 CELSR2 MAP4K5	3.84e-03	60	154	3	EFO_0022314
Disease	hypothyroidism	HFE FLT3 KCNH7 CD80 MRAP CLNK	3.86e-03	284	154	6	EFO_0004705
Disease	nevus count	KITLG FMN1	3.92e-03	18	154	2	EFO_0004632
Disease	level of Sphingomyelin (d34:1) in blood serum	USP24 NPFFR2	3.92e-03	18	154	2	OBA_2045175
Disease	Hemangiosarcoma	FLT1 PTPRB	3.92e-03	18	154	2	C0018923
Disease	cartilage thickness measurement	HAO1 PIK3R1	3.92e-03	18	154	2	EFO_0007873
Disease	free cholesterol in VLDL measurement	GALNT2 CELSR2 MAP4K5	4.02e-03	61	154	3	EFO_0022276
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	GALNT2 MOGAT2 MAP4K5	4.02e-03	61	154	3	EFO_0008317, EFO_0008596, EFO_0020946
Disease	Depressive disorder	DAOA PDE4A PDE4D GRM1 CRY2 MAPK3	4.21e-03	289	154	6	C0011581
Disease	triglycerides in medium LDL measurement	GALNT2 CELSR2 MAP4K5	4.21e-03	62	154	3	EFO_0022322
Disease	cholesteryl ester measurement, low density lipoprotein cholesterol measurement	HFE GALNT2 CELSR2 MAP4K5	4.36e-03	126	154	4	EFO_0004611, EFO_0010351
Disease	Osteochondrodysplasias	FLT1 ADAMTSL2	4.37e-03	19	154	2	C0029422
Disease	Dyschondroplasias	FLT1 ADAMTSL2	4.37e-03	19	154	2	C0013366
Disease	triglycerides to total lipids in IDL percentage	GALNT2 CELSR2 MAP4K5	4.40e-03	63	154	3	EFO_0022329
Disease	rheumatoid arthritis, ACPA-positive rheumatoid arthritis, rheumatoid factor seropositivity measurement	FLT3 WDFY4 CLNK	4.40e-03	63	154	3	EFO_0000685, EFO_0007791, EFO_0009459
Disease	total lipids in HDL measurement	GALNT2 MOGAT2 MAP4K5	4.40e-03	63	154	3	EFO_0022307
Disease	cholesterol to total lipids in medium VLDL percentage	GALNT2 CELSR2 MAP4K5	4.40e-03	63	154	3	EFO_0022239
Disease	triglycerides:total lipids ratio, intermediate density lipoprotein measurement	GALNT2 MOGAT2 CELSR2 MAP4K5	4.49e-03	127	154	4	EFO_0008595, EFO_0020947
Disease	docosahexaenoic acid measurement	GALNT2 MOGAT2 CELSR2 MAP4K5	4.49e-03	127	154	4	EFO_0007761
Disease	PR interval	ARHGAP24 OBSCN DYSF RYR2 KLHL38 SEMA3A CREBRF MYO3A	4.60e-03	495	154	8	EFO_0004462
Disease	cholesteryl esters to total lipids in medium VLDL percentage	GALNT2 CELSR2 MAP4K5	4.60e-03	64	154	3	EFO_0022253
Disease	triglycerides in small LDL measurement	GALNT2 CELSR2 MAP4K5	4.81e-03	65	154	3	EFO_0022323
Disease	cholesterol in large VLDL measurement	GALNT2 CELSR2 MAP4K5	4.81e-03	65	154	3	EFO_0021902
Disease	cholesterol in very large VLDL measurement	GALNT2 CELSR2 MAP4K5	4.81e-03	65	154	3	EFO_0022230
Disease	chronic kidney disease (is_marker_for)	AZGP1 PAX2	4.83e-03	20	154	2	DOID:784 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SSLRPNQMLDWQRLK	LINC00311	46	Q8N616
YLTVKVWDLNMENRP	PPP2R2B	301	Q00005
RPSEWNRDTLPSNMY	CREBRF	451	Q8IUR6
NKPHMIQVYRSRKWR	ATP13A1	296	Q9HD20
DWDRKLQMAPNSYTA	FAM47DP	291	A6NHR8
SLMDKAFDPTRRQWY	CACHD1	746	Q5VU97
NASVLYWQMVRPFLK	CFAP46	131	Q8IYW2
FVAPRYNWMTLSQKL	ABCA3	391	Q99758
YLSVKVWDLNMESRP	PPP2R2D	311	Q66LE6
QPWYLSLMFRTRQAD	CELSR2	1636	Q9HCU4
MNIWPEYKNRTIFDI	CD80	81	P33681
YLCWVKMARSRLNEP	C22orf42	226	Q6IC83
RLCWNKQDPNYLATM	DCAF7	226	P61962
SVASQSCLRKRMPWY	CCDC27	216	Q2M243
WFQEYMNSKDRRLSP	NUP93	351	Q8N1F7
KRYSSIPQMWSRCLL	DENND4A	751	Q7Z401
ILKYINMDSWNRSLL	NDST3	136	O95803
VEKPRILWALYFNMR	CHM	541	P24386
WRPPMYQRDDIIRSN	RC3H2	701	Q9HBD1
DWPNQEMRKIYTTVL	NPFFR2	311	Q9Y5X5
PMKPLYWTRIQISDR	FMN1	981	Q68DA7
ILIYKNRVRMNTFPW	PTPN4	241	P29074
EYKRQNPTMFAWEIR	PAX5	101	Q02548
SAWRKMRVYQREEVP	ARHGEF19	136	Q8IW93
SSTMAQAKRWLYQRP	UROD	171	P06132
YEASKDRRQPLERMW	DAOA	116	P59103
GLQNYRWKLVRTAPM	PTPRB	276	P23467
RNYLELMVELPWNKS	LONP2	311	Q86WA8
PSPSTLIYRNMQRWK	LIN37	201	Q96GY3
LEYMARLYRKRPQNW	MAGEE2	481	Q8TD90
PADSVMRQDYRAWKV	MAP6	116	Q96JE9
KRQWDRLYPDMLQSS	KCNH7	241	Q9NS40
KWDYMTPEQRRSRQG	GALNT2	281	Q10471
WKLDNRGRRMPLNAY	DDX60L	1611	Q5H9U9
SWRQTLRPLVKTMAY	PNMA6F	236	A0A0J9YX94
QALQDMARPLKQWLY	MKX	76	Q8IYA7
TKPLELYRQWTDRIM	PDE4A	596	P27815
KPLQLYRQWTDRIME	PDE4D	626	Q08499
WMSLYQSQRPEKQRQ	CES4A	546	Q5XG92
ALDNMYDARIPQLWK	DNAH8	4296	Q96JB1
RWKLYPRMLRNVAET	HAO1	46	Q9UJM8
IWRMYPNSTVHIQRL	MS4A10	156	Q96PG2
RFDPRYNKWMQVASL	KLHL9	371	Q9P2J3
RPLKQRMLEYFQTTW	KCNH4	506	Q9UQ05
RKQGVSPADMYRWKL	ADAMTSL2	556	Q86TH1
RRWGIQKNRPAMNYD	ETV5	406	P41161
ATRWYRAPEIMLNSK	MAPK3	206	P27361
RALNYYPQNITMKWL	HFE	226	Q30201
TRDQYLMWLTQKGVR	PIK3R1	576	P27986
MPREDRATWKSNYFL	RPLP0	1	P05388
MKSEYVITNNPWVRL	NBAS	2186	A2RRP1
WPYLTAEALKNRMGR	NPIPB15	231	A6NHN6
RMPRKTKNSYWQCSE	PHF14	761	O94880
EYKRQNPTMFAWEIR	PAX2	101	Q02962
AQRAVTKPRYMQWRE	ITPKA	306	P23677
EILRTEQWPRKLYMQ	PTOV1	291	Q86YD1
LLARSRWQRSLMSYK	OBSCN	6741	Q5VST9
SWLRYIQNRLQKIMG	MOGAT2	241	Q3SYC2
LKIPEQYRMTIWRGL	TP73	531	O15350
QYRMTIWRGLQDLKQ	TP73	536	O15350
MSWLPNGYVTLRDNK	ARHGAP24	501	Q8N264
QLWRELRDQPLTMAY	FCSK	306	Q8N0W3
NYVVRGNARLPVKWM	FLT3	841	P36888
WQMAPYENKARLRDF	ADAM30	181	Q9UKF2
RPQERSYMLQRWQED	ATRX	1661	P46100
SYWPKDRVMINRLDS	CHD9	2256	Q3L8U1
MAWVKYSIQERRPQL	KLHL20	236	Q9Y2M5
RKAWVANYERPRMNA	CRY2	246	Q49AN0
NRKRKWELDSYPIML	FUT10	71	Q6P4F1
KRTLERAYQMGWTPN	FBXL17	681	Q9UF56
ERATWKGRNISYPMI	C3orf20	296	Q8ND61
TLALAEKYRWMSPNQ	CERKL	356	Q49MI3
RVASYARKWQQMRPI	CYP4V2	36	Q6ZWL3
LVYVNRKWTNLSDPM	BPIFB6	181	Q8NFQ5
NMRVPTLWQKHAYRS	DNAH14	3241	Q0VDD8
EAYKMAWLSQRQLAR	MACC1	176	Q6ZN28
WSVMAYEAKLPRQAS	DGKD	446	Q16760
AMSRPILYSNWLSKD	DYNC1H1	2866	Q14204
WLLQDPGMRLRTTYK	GLB1L2	151	Q8IW92
GMQKLASQYLKRDWP	FCHSD2	56	O94868
QARAMLDIVKRYNWT	GRM1	211	Q13255
QAPTIKELMRWYCLN	SCNN1G	21	P51170
TSPLNRFKYMWKLLR	SPACA1	141	Q9HBV2
WQMALYKDLPNRTDD	RYR2	3526	Q92736
RDPRAWIYSMLYNSK	DSEL	1031	Q8IZU8
WMLQGDKRVAYQRVP	DYSF	796	O75923
WKNVRYHMPVQRRSP	IL1R1	531	P14778
DRTYVLQNSMLPSIW	CUL4B	311	Q13620
KWLVPESSGRYVNRM	DCAF15	561	Q66K64
PRKCTWLYVINNTLM	MAP4K5	551	Q9Y4K4
YRWLKDNMPLELSGR	DSCAM	256	O60469
TQLNAKWDRINRMYS	UTRN	1951	P46939
MPREDRATWKSNYFL	RPLP0P6	1	Q8NHW5
RRRKIWDMYGPQTQL	TRMT44	386	Q8IYL2
NLPAESVKILRDWMY	TGIF2LX	56	Q8IUE1
RWSRLCLPKQYLFTM	TRNT1	16	Q96Q11
WLQRAQMDTLLYNSP	SPATA2L	406	Q8IUW3
NTDPMKRCLQRYSWP	SUPT20HL1	231	Q3ZLR7
FPMEIRQYLAQWLEK	STAT1	26	P42224
ILWYNMLVAEPRNLS	STAT1	471	P42224
PTKYRMFIWRSLLQL	TBC1D31	426	Q96DN5
NLPAESVKILRDWMY	TGIF2LY	56	Q8IUE0
TTEFRDKYQAWPMPR	SAXO1	271	Q8IYX7
RPFKRMNYSDAIVWL	NARS1	386	O43776
RVFISNIPYDMKWQA	MYEF2	101	Q9P2K5
PQLQLTLSDRWYEVM	AATK	361	Q6ZMQ8
SWKRYPASMKQLQQR	LRRTM3	441	Q86VH5
VARLWIANYSLPRAM	PRPF4	176	O43172
VAPWALKYMNRRASQ	SLC22A9	396	Q8IVM8
SQYIEWLQKLMRSEP	F7	441	P08709
KAQRAVTKPRYMQWR	ITPKB	786	P27987
VTKPRYMQWRETISS	ITPKB	791	P27987
RSNWEIYRKPIVIMS	PIRT	46	P0C851
LMYFNRTSLPWQGLK	CSNK1A1	211	P48729
PRQLYKSSNMTQRWQ	NBEA	2276	Q8NFP9
KQHDVRPWMQALRYT	SMG1	1386	Q96Q15
ILLYMSWSASPQMRN	MRAP	56	Q8TCY5
DYRPIAMQSLWNIKV	INPPL1	496	O15357
TNVYWVAPVEMKRRN	ST3GAL6	26	Q9Y274
YWKKRQPSLTRAVEN	KITLG	236	P21583
TPSQKVWYRDFMQLI	SEMA3A	696	Q14563
NWLSVSRKMQASPEY	ARHGAP35	291	Q9NRY4
RNWRPYCGMLSKSDI	DIS3	351	Q9Y2L1
DNKRTIGWMNFRLPL	TMC1	261	Q8TDI8
ALNKNWRYIVPMLTV	AKR1A1	291	P14550
RWPTMTYRLLNLSKV	ASCC3	1101	Q8N3C0
ATGQYQRMNKPLLDW	CLNK	36	Q7Z7G1
SSRQRMWSKYPLDVQ	SLC7A6OS	281	Q96CW6
RYMRQPIKQELSCKW	ZIC3	241	O60481
PAERETRLWNKYMSN	USP4	176	Q13107
LPWIYSKMEVRSLQQ	TMPRSS13	551	Q9BYE2
WYRQDCRKEPKLLMS	TRAV12-1	56	A0A0B4J245
ILYRWYMQDSNPTRK	ZFHX2	1871	Q9C0A1
LYKNPREWTRMVIRN	PYGM	791	P11217
PWLQDAYLMKLRRQT	SPEG	3216	Q15772
YPGSDRIMLQKWQKR	WDFY4	2531	Q6ZS81
VWRAMLARYVPNKGV	SNRNP35	31	Q16560
ADPYEEAWNQMLLRR	SLC9A1	656	P19634
YRLSMTIPDWLQAIQ	VASH2	101	Q86V25
QWKQRHPRSYNMVTL	RNF121	71	Q9H920
WYFTPANLEKLRNIM	SGSM1	951	Q2NKQ1
YEMLKRWRQQQPAGL	TNFRSF25	376	Q93038
LKALMTQRTYLQWPK	TLR6	751	Q9Y2C9
QWLAPAQRDLYRDVM	ZNF582	21	Q96NG8
PRYEDVKNMNTWLLF	ZDHHC11	206	Q9H8X9
YNSKDRKSQPMGLWR	AZGP1	61	P25311
RSIKYDEQIRFPWML	USP24	1896	Q9UPU5
KWLQPAQRDLYRCVM	ZNF140	21	P52738
GRDSMQLIYRWTKSL	SNAPC4	381	Q5SXM2
LSALQALMPWRYALK	TMC6	221	Q7Z403
NNYPTIRKTLRLWMD	VPS33A	461	Q96AX1
ARYWEMREQRTPTLK	ZNF367	276	Q7RTV3
PRYEDVKNMNTWLLF	ZDHHC11B	206	P0C7U3
PSWSAMRNRKYNCTL	POLR1B	1086	Q9H9Y6
RVQMTWSYPDEKNKR	FLT1	261	P17948
SRQKIDPLLYMTEWF	TBC1D10A	261	Q9BXI6
LYRLMQRCWALSPKD	PTK7	1036	Q13308
LRMLQQRYPKDSTAW	WDR87	2736	Q6ZQQ6
VKSLMYWLDPNLRYA	PTDSS1	126	P48651
VTVLKAPNRQLMTYW	TBC1D2B	116	Q9UPU7
EWLNPAQRNLYRKVM	ZNF583	21	Q96ND8
NQWRLGEPMLVARYS	KLHL38	361	Q2WGJ6
LDAPWRLYNKIINLM	LIPA	381	P38571
NLKSQYFWRPKRMEL	MYO3A	811	Q8NEV4