Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainSSD

DISP2 PTCHD3

1.67e-0413282PS50156
DomainSSD

DISP2 PTCHD3

1.67e-0413282IPR000731
DomainTBC

TBC1D23 EVI5L

2.44e-0349282SM00164
DomainRabGAP-TBC

TBC1D23 EVI5L

2.85e-0353282PF00566
DomainGPCR_Rhodpsn_7TM

OR1E1 OR1E2 P2RY8 OR4P4 OPN1SW

2.90e-03670285IPR017452
Domain7tm_1

OR1E1 OR1E2 P2RY8 OR4P4 OPN1SW

3.03e-03677285PF00001
DomainTBC_RABGAP

TBC1D23 EVI5L

3.06e-0355282PS50086
DomainRab-GTPase-TBC_dom

TBC1D23 EVI5L

3.06e-0355282IPR000195
DomainG_PROTEIN_RECEP_F1_1

OR1E1 OR1E2 P2RY8 OR4P4 OPN1SW

3.19e-03685285PS00237
DomainG_PROTEIN_RECEP_F1_2

OR1E1 OR1E2 P2RY8 OR4P4 OPN1SW

3.31e-03691285PS50262
DomainGPCR_Rhodpsn

OR1E1 OR1E2 P2RY8 OR4P4 OPN1SW

3.33e-03692285IPR000276
DomainUCH

PAN2 USP9X

5.05e-0371282PF00443
DomainUSP_3

PAN2 USP9X

5.19e-0372282PS50235
DomainUSP_dom

PAN2 USP9X

5.19e-0372282IPR028889
DomainPeptidase_C19_UCH

PAN2 USP9X

5.19e-0372282IPR001394
DomainC2

CADPS2 FER1L5

1.64e-02131282PF00168
DomainC2

CADPS2 FER1L5

1.78e-02137282SM00239
DomainC2

CADPS2 FER1L5

1.91e-02142282PS50004
DomainOlfact_rcpt

OR1E1 OR1E2 OR4P4

2.05e-02393283IPR000725
Pubmed

Odorant receptors govern the formation of a precise topographic map.

OR1E1 OR1E2

4.02e-0642929546391
Pubmed

Allelic inactivation regulates olfactory receptor gene expression.

OR1E1 OR1E2

6.70e-0652928087849
Pubmed

Mouse-human orthology relationships in an olfactory receptor gene cluster.

OR1E1 OR1E2

1.87e-05829211170746
Pubmed

Identification of potential regulatory motifs in odorant receptor genes by analysis of promoter sequences.

OR1E1 OR1E2

1.87e-05829216902085
Pubmed

Sensitivity-dependent hierarchical receptor codes for odors.

OR1E1 OR1E2

2.41e-05929212588732
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ORC1 SLC6A8 DISP2 RADIL HIVEP2 UBE4B EVI5L

2.71e-05110529735748872
Pubmed

Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire.

OR1E1 OR1E2

3.68e-05112928004088
Pubmed

Supersensitive detection and discrimination of enantiomers by dorsal olfactory receptors: evidence for hierarchical odour coding.

OR1E1 OR1E2

3.68e-051129226361056
Pubmed

Evolution of odorant receptors expressed in mammalian testes.

OR1E1 OR1E2

5.21e-051329211014824
Pubmed

Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb.

OR1E1 OR1E2

6.07e-05142927528109
Pubmed

Quantitative trait loci for steady-state platelet count in mice.

OR1E1 OR1E2

7.00e-051529215520881
Pubmed

Voxelwise genome-wide association study (vGWAS).

CADPS2 CSMD2

7.00e-051529220171287
Pubmed

Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.

OR1E1 OR1E2

8.00e-051629210673334
Pubmed

Olfactory receptors and signalling elements in the Grueneberg ganglion.

OR1E1 OR1E2

9.06e-051729216805845
Pubmed

Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis.

TBC1D23 USP9X

1.02e-041829233323119
Pubmed

Temporal profiling of photoreceptor lineage gene expression during murine retinal development.

OPN1SW PRDM1

1.14e-041929228288836
Pubmed

Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development.

OPN1SW PRDM1

1.14e-041929220110327
Pubmed

The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates.

OR1E1 OR1E2

1.68e-042329210706615
Pubmed

Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.

OR1E1 OR1E2

1.83e-04242929119360
Pubmed

Distribution of olfactory receptor genes in the human genome.

OR1E1 OR1E2

2.50e-04282929500546
Pubmed

Blimp1 suppresses Chx10 expression in differentiating retinal photoreceptor precursors to ensure proper photoreceptor development.

OPN1SW PRDM1

3.49e-043329220463215
Pubmed

DNA Damage Regulates Translation through β-TRCP Targeting of CReP.

HIVEP2 UBE4B

3.93e-043529226091241
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

TTC17 HIVEP2 TBC1D23 CADPS2 UBE4B USP9X

5.75e-04128529635914814
Pubmed

Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.

TBC1D23 EVI5L

5.93e-044329219077034
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR1E1 OR1E2 OR4P4

7.97e-0421929312213199
Cytoband17p13.3

OR1E1 OR1E2

1.43e-038829217p13.3
GeneFamilyOlfactory receptors, family 1

OR1E1 OR1E2

1.28e-0340242147
GeneFamilyUbiquitin specific peptidases

PAN2 USP9X

2.49e-0356242366
ToppCellCD8+_Memory_T_cell-FLU-1|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

P2RY8 SLC6A8 PZP PRDM1

3.59e-0616229476f39935763848ea6e7917b2f9f1432c543063d9
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

P2RY8 SAMD9 PRDM1

1.27e-04151293e1ffd99001b6a5b795f3367882a9355955c0e569
ToppCellHealthy_Control-Lymphoid-Plasma|Healthy_Control / Condition, Lineage, Cell class and cell subclass

P2RY8 DISP2 PRDM1

1.59e-041632932913ccdd4613472cd82077d4993e1d9f8b223398
ToppCellHealthy_Control-Lymphoid-Plasma-|Healthy_Control / Condition, Lineage, Cell class and cell subclass

P2RY8 DISP2 PRDM1

1.59e-04163293b589ff57d58dcb215ee3b5a10d81f43e5752a196
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ORC1 SLC6A8 DISP2

1.65e-0416529362457b7b74c6eae42d91d65e7dc6df6bf8e061f7
ToppCellLV-17._Lymphocyte|World / Chamber and Cluster_Paper

P2RY8 PZP PRDM1

1.90e-04173293212f013ff761cbab24a537071739867c08c402a4
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c12-MKI67-TYROBP|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ORC1 RAD18 EVI5L

1.96e-0417529386dfce849b2ec023a72f7e887fa681b117155e51
ToppCellLA-17._Lymphocyte|World / Chamber and Cluster_Paper

P2RY8 PZP PRDM1

2.06e-0417829334ec499d03cc198cfefa19a724d4c81974052f65
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

P2RY8 PZP PRDM1

2.17e-041812935cecbafc29cc95896e6ccb2c74d9237b9aaece69
ToppCellCOVID-19-kidney-NK|COVID-19 / Disease (COVID-19 only), tissue and cell type

P2RY8 SAMD9 PZP

2.17e-041812938906ee8a7a1616dfe8c3b5c73988416641213629
ToppCellLA-17._Lymphocyte|LA / Chamber and Cluster_Paper

P2RY8 PZP PRDM1

2.17e-041812933fd9f805fa46141b0fa7023ee5d8688d338635d5
ToppCellLV-17._Lymphocyte|LV / Chamber and Cluster_Paper

P2RY8 PZP PRDM1

2.17e-0418129381fafa69c8c240250a667a5f3b321e8be1b9a288
ToppCellRA-17._Lymphocyte|RA / Chamber and Cluster_Paper

P2RY8 PZP PRDM1

2.20e-04182293257a7847917b6ea1d60608183d90300bfd028758
ToppCellRA-17._Lymphocyte|World / Chamber and Cluster_Paper

P2RY8 PZP PRDM1

2.24e-041832936397f684a50346fc42cccb5afbe10350f4b2d9b0
ToppCellControl-Lymphocyte-T_NK-CD4_TEM|Control / Disease, Lineage and Cell Type

P2RY8 PZP PRDM1

2.31e-041852938d6a089dcb4bfb0e74b6316fb7221688c1835e6e
ToppCellmild_COVID-19-CD4+_CTL|mild_COVID-19 / disease group, cell group and cell class (v2)

P2RY8 PZP PRDM1

2.38e-0418729349196d07e4716c87d33229a4569bdb6b4613b3eb
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T-T_CD8-MAIT|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

P2RY8 PZP PRDM1

2.46e-04189293159b0979c93b7d98aaeeb43fba5983a9f67b9c9d
ToppCell3'_v3-Lung-Lymphocytic_T_CD8-Tem/emra_CD8|Lung / Manually curated celltypes from each tissue

P2RY8 PZP PRDM1

2.46e-04189293f43bb9db7bb2d19c9849cd3ed892fe3e09e7dfe2
ToppCellCOVID-19-kidney-NK|kidney / Disease (COVID-19 only), tissue and cell type

P2RY8 SAMD9 PZP

2.50e-04190293e3ca3c9fb9e27670a5dd128dd6564ff98a57159e
ToppCellIPF-Lymphoid-T_Cytotoxic|IPF / Disease state, Lineage and Cell class

P2RY8 PZP PRDM1

2.50e-04190293e5d0186bfb416a3eda76ac12b9379650afb6f409
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

P2RY8 PZP PRDM1

2.54e-041912934a29b7d5cd10e9077699d3aa76e3db6c4d5a0cf6
ToppCellCOPD-Lymphoid-T_Cytotoxic|World / Disease state, Lineage and Cell class

P2RY8 PZP PRDM1

2.58e-041922935bfd9f5d47511441eb2d3cc3c4d7ed330ffd0bd1
ToppCellCOPD-Lymphoid-T_Cytotoxic|COPD / Disease state, Lineage and Cell class

P2RY8 PZP PRDM1

2.62e-0419329358e94fe2e89cdafc6974938f97a4c162061a437d
ToppCellIPF-Lymphoid-T_Cytotoxic|World / Disease state, Lineage and Cell class

P2RY8 PZP PRDM1

2.62e-0419329335c902a983d7f1156a74fe68ee366609029833b3
ToppCellChildren_(3_yrs)-Immune-T_lymphocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

P2RY8 PZP PRDM1

2.62e-04193293b9769b45125d2244afe53f9f71c92c04ddccf980
ToppCellCOVID-19_Severe-CD8+_T_activated|World / disease group, cell group and cell class

SAMD9 PZP PRDM1

2.62e-04193293ddc1db516568e03be8e82b2ca770c67756418185
ToppCellChildren_(3_yrs)-Immune-T_lymphocyte-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

P2RY8 HIVEP2 PRDM1

2.66e-041942933d6f2d190dd50804afea299957cc44c2bb756134
ToppCellPrimary_Visual_cortex_(V1C)|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RADIL HIVEP2 CADPS2

2.70e-0419529324dbb125565facd2de42d848471d4867c81acf80
ToppCelldistal-Hematologic-CD4+_Naive_T-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

P2RY8 EIF3E PRDM1

2.78e-04197293bbb7283cbda60d3efe048a2b501f9bfa533190a6
ToppCellBAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

P2RY8 SAMD9 PRDM1

2.78e-04197293b3876076684781fb8384117f2cf367d828985986
ToppCellBAL-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

P2RY8 SAMD9 PRDM1

2.78e-041972930b4fdf0131dd67a86ee3209fa66db0ca2e01a10e
ToppCell10x_3'_v3-blood_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD4-positive,_alpha-beta_memory_T_cell|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HIVEP2 EIF3E PRDM1

2.82e-04198293b0b0977d9482538a076b84a8dc8b15ed682662f9
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T-T_CD3|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

P2RY8 PZP PRDM1

2.82e-041982933c23fb8a84d4e4a20f7fa60055c7b37fc45a29d5
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T-T_CD3-NKT|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

P2RY8 PZP PRDM1

2.82e-041982939ce9b3721fb8a154667211c29e60133412134c76
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-dn_T|COVID-19_Mild / Disease, condition lineage and cell class

P2RY8 SAMD9 HIVEP2

2.86e-04199293f307d4887b28cf60a591439e278fd668409cb104
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8-CD8_GZMK+|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

P2RY8 PZP PRDM1

2.90e-042002937a9c3f51d4a8fda5f1b7e0be6fcf9c1c92fffe99
ToppCellmild-CD8+_Tem|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

P2RY8 PZP PRDM1

2.90e-04200293a7870c5728b2c17d1d0e4fe728599f186966861b
ToppCellSepsis-Leuk-UTI-Lymphocyte-T/NK-CD8+_Tem|Leuk-UTI / Disease, condition lineage and cell class

P2RY8 PZP PRDM1

2.90e-04200293aa8104dcb2ba5756a23c25a580bef2360ff25b13
ToppCellmild-CD8+_Tem|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SAMD9 PZP PRDM1

2.90e-04200293d8aec4904c9420b8f9d7508658ba1e36c66cdfcc
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

P2RY8 PZP PRDM1

2.90e-04200293c6c2b39359c65c9444987d02d1c899dff2ad1366
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Intermediate|3m / Sample Type, Dataset, Time_group, and Cell type.

DISP2 TTC17 HIVEP2

2.90e-04200293cbd0b9188a94778ffa539912aeb2a4378f0ab88f
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4_naive/CM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

P2RY8 PZP PRDM1

2.90e-04200293e0cec0a844b7c1f8edee4c005af27766754e470a
DiseaseFetal Growth Retardation

ORC1 SAMD9

1.75e-0420292C0015934
DiseaseIschemic stroke, fibrinogen measurement

TTC17 PMF1

1.34e-0355292EFO_0004623, HP_0002140
DiseaseCholestasis

PAN2 CADPS2

5.24e-03110292C0008370
DiseaseHepatitis, Toxic

PAN2 CADPS2 PZP

7.15e-03404293C0019193
DiseaseHepatitis, Drug-Induced

PAN2 CADPS2 PZP

7.15e-03404293C1262760
DiseaseChemically-Induced Liver Toxicity

PAN2 CADPS2 PZP

7.15e-03404293C4279912
DiseaseDrug-Induced Liver Disease

PAN2 CADPS2 PZP

7.15e-03404293C0860207
DiseaseDrug-Induced Acute Liver Injury

PAN2 CADPS2 PZP

7.15e-03404293C3658290
DiseaseChemical and Drug Induced Liver Injury

PAN2 CADPS2 PZP

7.15e-03404293C4277682
Diseasesevere acute respiratory syndrome, COVID-19

P2RY8 CADPS2 USP9X

9.42e-03447293EFO_0000694, MONDO_0100096
DiseaseIntellectual Disability

SLC6A8 HIVEP2 TBC1D23

9.42e-03447293C3714756
DiseaseParoxysmal atrial fibrillation

OPN1SW UBE4B

1.03e-02156292C0235480
DiseasePersistent atrial fibrillation

OPN1SW UBE4B

1.03e-02156292C2585653
Diseasefamilial atrial fibrillation

OPN1SW UBE4B

1.03e-02156292C3468561

Protein segments in the cluster

PeptideGeneStartEntry
LCIYQFEYMLQEQLP

EVI5L

241

Q96CN4
EQKPNRVFSCYVYQM

DCAF17

491

Q5H9S7
FQAQLMLICDPGYYY

CSMD2

2616

Q7Z408
YQVAFRMAYFPFVNL

DISP2

531

A7MBM2
QNMVLFAPNIYVLNY

PZP

981

P20742
YFNIAMIIPQCSHNY

RAD18

31

Q9NS91
MLASVLPFQIYYHCN

P2RY8

71

Q86VZ1
LLYFIQQKCPLYMQS

RADIL

516

Q96JH8
AYCNCMIQVLYFLEP

PAN2

526

Q504Q3
QLIHQPMYFFLNYLS

OR4P4

51

Q8NGL7
CYKCFYQLQPAMTQQ

PMF1

61

Q6P1K2
MCFQPYTYSQLQQIL

ORC1

676

Q13415
QLYVFVVRCIAYPFN

CADPS2

86

Q86UW7
FLYQPQYLNAIQTMC

EIF3E

236

P60228
YVQYMIAIINNCQTF

EXOC3

486

O60645
CQIPLMVYNQAFIYF

PTCHD3

776

Q3KNS1
PEQQNLCYALFLAMY

OR1E2

21

P47887
INEMCLIFLFYYPQN

MOXD2P

461

A6NHM9
PEQQNLCYALFLAMY

OR1E1

21

P30953
CIYNPIIYCFMNKQF

OPN1SW

296

P03999
FIFPASNVYLQYMRN

USP9X

1466

Q93008
QQYFNLFVMYANLGV

USP9X

2176

Q93008
PINMAYLQLFIYCAE

FER1L5

321

A0AVI2
PQFSECQYDYFQIKM

SAMD9

311

Q5K651
CQNGMNIYFYTIKPI

PRDM1

176

O75626
CMGIFIFNVVYYEPL

SLC6A8

531

P48029
VVMLCNQNYIRNPYL

UBE4B

916

O95155
YLQQADPFFIYFLML

TBC1D23

221

Q9NUY8
LIRCMQFYPFLYNIT

TTC17

731

Q96AE7
IQNALFQFQYPTVCM

HIVEP2

1201

P31629