Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentactomyosin

SYNPO2 CDC42BPB SH2B2 ZYX AMOT PALLD

3.60e-051171106GO:0042641
GeneOntologyCellularComponentcontractile actin filament bundle

SYNPO2 SH2B2 ZYX AMOT PALLD

2.56e-041071105GO:0097517
GeneOntologyCellularComponentstress fiber

SYNPO2 SH2B2 ZYX AMOT PALLD

2.56e-041071105GO:0001725
GeneOntologyCellularComponentactin filament bundle

SYNPO2 SH2B2 ZYX AMOT PALLD

4.02e-041181105GO:0032432
DomainAP-1

BATF FOSB FOSL1

1.54e-0591083IPR000837
Domain-

PITPNM2 PITPNM1 STARD9

3.06e-042310833.30.530.20
DomainSTART-like_dom

PITPNM2 PITPNM1 STARD9

3.06e-04231083IPR023393
DomainIP_trans

PITPNM2 PITPNM1

3.28e-0451082PF02121
DomainLNS2

PITPNM2 PITPNM1

4.89e-0461082IPR013209
DomainPI_transfer

PITPNM2 PITPNM1

4.89e-0461082IPR001666
DomainLNS2

PITPNM2 PITPNM1

4.89e-0461082SM00775
DomainDDHD

PITPNM2 PITPNM1

4.89e-0461082PF02862
DomainDDHD

PITPNM2 PITPNM1

4.89e-0461082PS51043
DomainDDHD_dom

PITPNM2 PITPNM1

4.89e-0461082IPR004177
DomainLNS2

PITPNM2 PITPNM1

4.89e-0461082PF08235
DomainLNS2/PITP

PITPNM2 PITPNM1

4.89e-0461082IPR031315
DomainDDHD

PITPNM2 PITPNM1

4.89e-0461082SM01127
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_TRANSPORT_OF_CALCIUM

CASP9 GRIN2C GRIN2D

1.25e-0418783M47761
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_TRANSPORT_OF_CALCIUM

CASP9 GRIN2C GRIN2D

1.48e-0419783M47677
PathwayKEGG_MEDICUS_REFERENCE_TRANSPORT_OF_CALCIUM

GRIN2C GRIN2D

2.99e-045782M47667
PathwayREACTOME_SYNTHESIS_OF_PI

PITPNM2 PITPNM1

2.99e-045782M26962
PathwayREACTOME_ASSEMBLY_AND_CELL_SURFACE_PRESENTATION_OF_NMDA_RECEPTORS

GRIN2C GRIN2D

2.99e-045782MM15655
PathwayREACTOME_SYNTHESIS_OF_PI

PITPNM2 PITPNM1

2.99e-045782MM14587
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ANKRD13D PITPNM2 SETD1A ABCA2 RNPEPL1 GRIN2D DYSF CDC42BPB SH2B2 TRAK1 RGMA ESRP2 C2CD3 KLF10 ZNF592 ELL ARHGAP33

9.54e-0811051121735748872
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PITPNM2 SETD1A ABCA2 AGAP11 GMEB2 URGCP USP10 ZNF592 AMOT FAM53B BSN PLXNB1

1.51e-075291121214621295
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

NRDE2 POLR1A BMP2K DYSF CDC42BPB ZYX USP10 UBA1 AMOT PRRC2A PALLD ZC3HAV1

4.00e-067241121236232890
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

ELOA DSC3 ENTR1 PPP2R3B TNS2 CDC42BPB SNX19 ZYX ARHGAP5 UBA1 C2CD3 PTPRZ1 CRYBG3 PRRC2A

7.31e-0610491121427880917
Pubmed

In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons.

GRIN2C GRIN2D

1.03e-052112229651654
Pubmed

Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes.

GRIN2C GRIN2D

1.03e-052112231110197
Pubmed

Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice.

GRIN2C GRIN2D

1.03e-052112235057644
Pubmed

NMDA receptors containing GluN2C and GluN2D subunits have opposing roles in modulating neuronal oscillations; potential mechanism for bidirectional feedback.

GRIN2C GRIN2D

1.03e-052112231786200
Pubmed

Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility.

GRIN2C GRIN2D

1.03e-052112229317596
Pubmed

NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice.

GRIN2C GRIN2D

1.03e-052112233766086
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

PDE3B ARHGEF5 ZYX TRAK1 C2CD3 AMOT STARD9 FAM53B CRYBG3 PALLD OTOG ZC3HAV1

2.25e-058611121236931259
Pubmed

Auditory pathway and auditory brainstem response in mice lacking NMDA receptor epsilon 1 and epsilon 4 subunits.

GRIN2C GRIN2D

3.08e-05311229718984
Pubmed

Cocaine preference and neuroadaptations are maintained by astrocytic NMDA receptors in the nucleus accumbens.

GRIN2C GRIN2D

3.08e-053112235867797
Pubmed

Cloning and characterization of a novel variant (mM-rdgBbeta1) of mouse M-rdgBs, mammalian homologs of Drosophila retinal degeneration B gene proteins, and its mRNA localization in mouse brain in comparison with other M-rdgBs.

PITPNM2 PITPNM1

3.08e-053112212562526
Pubmed

Pitpnm1 is expressed in hair cells during development but is not required for hearing.

PITPNM2 PITPNM1

3.08e-053112223820044
Pubmed

Facilitation of GluN2C-containing NMDA receptors in the external globus pallidus increases firing of fast spiking neurons and improves motor function in a hemiparkinsonian mouse model.

GRIN2C GRIN2D

3.08e-053112233421565
Pubmed

Differential Expression of MUC12, MUC16, and MUC20 in Patients with Active and Remission Ulcerative Colitis.

MUC16 MUC12

3.08e-053112226770020
Pubmed

Chromosomal localization, genomic organization and evolution of the genes encoding human phosphatidylinositol transfer protein membrane-associated (PITPNM) 1, 2 and 3.

PITPNM2 PITPNM1

3.08e-053112215627748
Pubmed

Hemicentins assemble on diverse epithelia in the mouse.

DSC3 HMCN1

3.08e-053112217015624
Pubmed

Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels.

GRIN2C GRIN2D

3.08e-05311229480759
Pubmed

A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation.

BATF FOSL1

3.08e-053112235511484
Pubmed

Cloning, genomic organization and chromosomal assignment of the mouse p190-B gene.

ARHGAP5 AHR

3.08e-05311229838117
Pubmed

A genome-wide association study identifies protein quantitative trait loci (pQTLs).

DSC3 DYSF SACS STARD9

4.62e-0561112418464913
Pubmed

Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.

SNX19 HPS1 PRRC2A PALLD

4.92e-0562112417975119
Pubmed

Gene variants associated with ischemic stroke: the cardiovascular health study.

SNX19 HPS1 PRRC2A PALLD

5.24e-0563112419023099
Pubmed

A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers.

FOSB FOSL1

6.14e-054112212371906
Pubmed

Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf.

BATF ETS1

6.14e-054112231665634
Pubmed

Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.

PDE3B PIK3R5

6.14e-054112216476736
Pubmed

Functional correlation of NMDA receptor epsilon subunits expression with the properties of single-channel and synaptic currents in the developing cerebellum.

GRIN2C GRIN2D

6.14e-05411228699248
Pubmed

Neuronal ER-plasma membrane junctions organized by Kv2-VAP pairing recruit Nir proteins and affect phosphoinositide homeostasis.

PITPNM2 PITPNM1

6.14e-054112231594866
Pubmed

Regulation of the human involucrin gene promoter by co-activator proteins.

FOSB FOSL1

6.14e-054112215025563
Pubmed

Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein.

PITPNM2 PITPNM1

6.14e-054112210022914
Pubmed

Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine.

PITPNM2 PITPNM1

6.14e-054112211104777
Pubmed

Role of the carboxy-terminal region of the GluR epsilon2 subunit in synaptic localization of the NMDA receptor channel.

GRIN2C GRIN2D

6.14e-05411229768843
Pubmed

Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.

GRIN2C GRIN2D

6.14e-054112236309015
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

ANKRD13D COL6A1 ABCA12 TNS2 CPT2 SH2B2

7.04e-05214112622199357
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

C15orf62 SETD1A SYNPO2 ARHGEF5 LMTK3 KRT76 INAVA BSN

7.93e-05430112835044719
Pubmed

An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets.

BATF ETS1 AHR

8.01e-0526112333238123
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

GMEB2 IFI16 ZYX USP10 UBA1 KLF10 PALLD ZC3HAV1

9.90e-05444112834795231
Pubmed

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.

GRIN2C GRIN2D

1.02e-045112226919761
Pubmed

Distinct distributions of five NMDA receptor channel subunit mRNAs in the brainstem.

GRIN2C GRIN2D

1.02e-04511227518475
Pubmed

Distinct spatiotemporal expressions of five NMDA receptor channel subunit mRNAs in the cerebellum.

GRIN2C GRIN2D

1.02e-04511227518474
Pubmed

Synapse-selective impairment of NMDA receptor functions in mice lacking NMDA receptor epsilon 1 or epsilon 2 subunit.

GRIN2C GRIN2D

1.02e-04511229147327
Pubmed

Neurotransmission and bipolar disorder: a systematic family-based association study.

GRIN2C GRIN2D

1.02e-045112218444252
Pubmed

Specific localization of transcription factors in the chromatin of mouse mature spermatozoa.

ETS1 POU5F1B

1.02e-045112211550273
Pubmed

Distinct gene expression of the N-methyl-D-aspartate receptor channel subunit in peripheral neurons of the mouse sensory ganglia and adrenal gland.

GRIN2C GRIN2D

1.02e-04511228015722
Pubmed

Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain.

GRIN2C GRIN2D

1.02e-045112215003177
Pubmed

GABAA, GABAC, and NMDA receptor subunit expression in the suprachiasmatic nucleus and other brain regions.

GRIN2C GRIN2D

1.02e-04511227723623
Pubmed

Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor.

GRIN2C GRIN2D

1.02e-045112212082569
Pubmed

Heterozygous deletion of NR1 subunit of the NMDA receptor alters ethanol-related behaviors and regional expression of NR2 subunits in the brain.

GRIN2C GRIN2D

1.02e-045112221945132
Pubmed

Five common gene variants identify elevated genetic risk for coronary heart disease.

SNX19 PALLD

1.02e-045112218073581
Pubmed

Roles of the glutamate receptor epsilon2 and delta2 subunits in the potentiation and prepulse inhibition of the acoustic startle reflex.

GRIN2C GRIN2D

1.02e-045112211488959
Pubmed

Developmental changes in distribution of NMDA receptor channel subunit mRNAs.

GRIN2C GRIN2D

1.02e-04511221493227
Pubmed

N-methyl-D-aspartic acid receptor structure and function.

GRIN2C GRIN2D

1.02e-04511228036251
Pubmed

NMDA receptor activation by HIV-Tat protein is clade dependent.

GRIN2C GRIN2D

1.02e-045112219020013
Pubmed

Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry.

SNX19 PALLD

1.02e-045112219752551
Pubmed

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.

GRIN2C GRIN2D

1.02e-045112226875626
Pubmed

Differential distributions of the NMDA receptor channel subunit mRNAs in the mouse retina.

GRIN2C GRIN2D

1.02e-04511227510577
Pubmed

Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene.

GRIN2C GRIN2D

1.02e-04511228756432
Pubmed

Differential interaction of NMDA receptor subtypes with the post-synaptic density-95 family of membrane associated guanylate kinase proteins.

GRIN2C GRIN2D

1.02e-045112218233995
Pubmed

Distinct spatiotemporal distributions of the N-methyl-D-aspartate receptor channel subunit mRNAs in the mouse cervical cord.

GRIN2C GRIN2D

1.02e-04511227929904
Pubmed

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

GRIN2D LMTK3 PTPRZ1 BSN PRRC2A ARHGAP33

1.07e-04231112616452087
Pubmed

A role for spermine oxidase as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity.

GRIN2C GRIN2D

1.53e-046112223665428
Pubmed

Altered gene expression of the N-methyl-D-aspartate receptor channel subunits in Purkinje cells of the staggerer mutant mouse.

GRIN2C GRIN2D

1.53e-04611228996814
Pubmed

NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit.

GRIN2C GRIN2D

1.53e-046112215317856
Pubmed

Cortical consequences of HIV-1 Tat exposure in rats are enhanced by chronic cocaine.

GRIN2C GRIN2D

1.53e-046112225760043
Pubmed

Analysis of recombinant inbred lines derived from "autoimmune" (NZB) and "high leukemia" (C58) strains: independent multigenic systems control B cell hyperactivity, retrovirus expression, and autoimmunity.

AHR PGM2

1.53e-04611226980942
Pubmed

Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo.

GRIN2C GRIN2D

1.53e-04611229458051
Pubmed

H3K4 Methyltransferase Set1a Is A Key Oct4 Coactivator Essential for Generation of Oct4 Positive Inner Cell Mass.

SETD1A POU5F1B

1.53e-046112226785054
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

ELOA IFI16 ZYX URGCP PITPNM1 USP10 UBA1 ZNF592 PRRC2A ZC3HAV1

2.07e-047741121015302935
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

PITPNM2 RBP3 CDC42BPB PITPNM1 CDKL5 ARHGAP5 USP10 UBA1 KRT76 SACS PTPRZ1 AMOT BSN PRRC2A

2.08e-0414311121437142655
Pubmed

HIV immune complexes prevent excitotoxicity by interaction with NMDA receptors.

GRIN2C GRIN2D

2.14e-047112222940423
Pubmed

Early onset of NMDA receptor GluR epsilon 1 (NR2A) expression and its abundant postsynaptic localization in developing motoneurons of the mouse hypoglossal nucleus.

GRIN2C GRIN2D

2.14e-047112212103442
Pubmed

Human immunodeficiency virus-1 protein Tat induces excitotoxic loss of presynaptic terminals in hippocampal cultures.

GRIN2C GRIN2D

2.14e-047112223267846
Pubmed

Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death.

GRIN2C GRIN2D

2.14e-047112219036954
Pubmed

Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.

GRIN2C GRIN2D

2.14e-047112222833210
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

IFI16 ZYX USP10 UBA1 KLF10 PRRC2A PALLD ZC3HAV1

2.31e-04503112816964243
Pubmed

HIV-1 subtypes B and C Tat differentially impact synaptic plasticity expression and implicates HIV-associated neurocognitive disorders.

GRIN2C GRIN2D KLF10

2.53e-0438112325613138
Pubmed

Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons.

GRIN2C GRIN2D

2.84e-04811228804048
Pubmed

The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid.

GRIN2C GRIN2D

2.84e-04811228845955
Pubmed

HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons.

GRIN2C GRIN2D

2.84e-04811228563977
Pubmed

HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures.

GRIN2C GRIN2D

2.84e-04811228821747
Pubmed

Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity.

GRIN2C GRIN2D

2.84e-04811227695237
Pubmed

Endogenous β-glucocerebrosidase activity in Abca12⁻/⁻epidermis elevates ceramide levels after topical lipid application but does not restore barrier function.

ABCA2 ABCA12

2.84e-048112224293640
Pubmed

Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept.

BSN CDH12

2.84e-048112219567891
Pubmed

HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes.

GRIN2C GRIN2D

2.84e-048112217360663
Pubmed

Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120.

GRIN2C GRIN2D

2.84e-04811228724036
Pubmed

Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine.

GRIN2C GRIN2D

2.84e-04811228822372
Pubmed

Binding site specificity and factor redundancy in activator protein-1-driven human papillomavirus chromatin-dependent transcription.

FOSB FOSL1

2.84e-048112221937452
Pubmed

Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production.

GRIN2C GRIN2D

2.84e-048112221106831
Pubmed

Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures.

GRIN2C GRIN2D

2.84e-048112210448428
Pubmed

Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase.

GRIN2C GRIN2D

2.84e-04811228955056
Pubmed

Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system.

GRIN2C GRIN2D

2.84e-048112210555109
Pubmed

MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment.

USP30 RNF34 USP10

2.94e-0440112330759391
Pubmed

Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3.

ZYX ELL

3.65e-049112212659632
Pubmed

D1/NMDA receptors and concurrent methamphetamine+ HIV-1 Tat neurotoxicity.

GRIN2C GRIN2D

3.65e-049112222552781
Pubmed

Activation of cannabinoid type 2 receptors inhibits HIV-1 envelope glycoprotein gp120-induced synapse loss.

GRIN2C GRIN2D

3.65e-049112221670103
Pubmed

PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A.

GRIN2C GRIN2D

3.65e-04911229892651
Pubmed

The mouse gcd2 mutation causes primordial germ cell depletion.

LGR4 POU5F1B

3.65e-049112216822657
Pubmed

Identification and validation of selective deubiquitinase inhibitors.

USP30 USP10

3.65e-049112234129829
InteractionTOP3B interactions

ANKRD13D PITPNM2 SETD1A ABCA2 RNPEPL1 APBA1 GRIN2D DYSF CDC42BPB SH2B2 TRAK1 RGMA ESRP2 USP10 C2CD3 KLF10 ZNF592 MMS19 PRRC2A ELL ARHGAP33 ZC3HAV1

9.13e-06147010822int:TOP3B
GeneFamilyBasic leucine zipper proteins|Fos transcription factor family

FOSB FOSL1

1.01e-0447521256
GeneFamilyPhosphatidylinositol transfer proteins

PITPNM2 PITPNM1

2.52e-0467521151
GeneFamilyGlutamate ionotropic receptor NMDA type subunits

GRIN2C GRIN2D

3.52e-0477521201
GeneFamilyBasic leucine zipper proteins

BATF FOSB FOSL1

1.10e-0349753506
GeneFamilyATP binding cassette subfamily A

ABCA2 ABCA12

1.50e-0314752805
GeneFamilyCD molecules|Mucins

MUC16 MUC12

3.39e-0321752648
CoexpressionGSE14308_TH17_VS_NATURAL_TREG_DN

PITPNM2 SETD1A GMEB2 DALRD3 PITPNM1 LINC00612 PIK3R5

2.36e-052001117M3390
CoexpressionGSE14026_TH1_VS_TH17_UP

ELOA ENTR1 GMEB2 RGMA USP10 TMEM171 BOLL

2.36e-052001117M3356
CoexpressionGSE17721_CTRL_VS_LPS_2H_BMDC_DN

SYNPO2 DSC3 GRIN2C PTPRZ1 SOX14 CRYBG3 PALLD

2.36e-052001117M3688
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A1 TMEM201 ABCA2 LGR4 ARHGAP5 HMCN1 CRYBG3 PLXNB1

1.64e-081771128c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_basal-Suprabasal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DSC3 ABCA12 MUC16 POU5F1B CMYA5 ERN2 FAT2 PTPRZ1

3.93e-081981128de5987588b9fa9ee8c595ba06d7d844ead0e3c74
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_basal-Suprabasal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DSC3 MUC16 CMYA5 LMTK3 ERN2 FOSL1 FAT2 PTPRZ1

4.24e-082001128ce969c958a31145bbfe315a9a865d7900ecc9549
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-14|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PITPNM2 COL6A1 USP30 RUBCNL ASPHD2 TRAK1 PLD4

3.07e-07175112787e557f7508c88b2087db5d57e77d5e2c92ca083
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D175|Adult / Lineage, Cell type, age group and donor

BMP2K BATF RUBCNL APBA1 GRIN2C GCNT1 ELL

4.47e-071851127ab5704b96f1d368911308797d10c7c52766ab134
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-bronchial_smooth_muscle_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNPO2 DSC3 ARHGEF5 LGR4 CMYA5 RBPMS2 PALLD

5.16e-0718911274dc32b463546bbe7250dddd281b92ad17ec22da1
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Airway_Smooth_Muscle|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNPO2 DSC3 ARHGEF5 LGR4 CMYA5 RBPMS2 PALLD

5.16e-0718911270d06bf0d7191d13a1c4f30a7881e7ea1093bfd6f
ToppCellproximal-Epithelial-Differentiating_Basal-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MUC16 LMTK3 ERN2 FAT2 PTPRZ1 INAVA SORD

7.29e-071991127c607346f60e5997e757e5a31cab412ab3734377b
ToppCellproximal-3-Epithelial-Differentiating_Basal|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MUC16 LMTK3 ERN2 FAT2 PTPRZ1 INAVA SORD

7.29e-07199112712e07084fc2d5d4c418df564ccc0e132b056e549
ToppCellproximal-Epithelial-Differentiating_Basal|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MUC16 LMTK3 ERN2 FAT2 PTPRZ1 INAVA SORD

7.29e-07199112796a89a2578fad9a99c52d2cf9e26e06516a96568
ToppCellTracheal|World / Cell types per location group and 10X technology with lineage, and cell group designations

LGR4 MUC16 CMYA5 ERN2 PTPRZ1 GPT2 CDH12

7.54e-072001127682960e28542a3d6c119047cd0131941932cfdea
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C15orf62 MUC16 GRIN2C GCNT1 FOSL1 INAVA

4.13e-061671126720dc5855c856b478b5ca90156b30bfcc5518d60
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-6|TCGA-Bladder / Sample_Type by Project: Shred V9

DSC3 ABCA12 IFI16 MSGN1 TMEM171 FAT2

4.73e-0617111260e78389f8f3d54570a6deb3dd307b865b46307e9
ToppCellwk_20-22-Epithelial-Proximal_epithelial-Proximal_secretory_3|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

C15orf62 MUC16 LMTK3 TMEM171 FAT2 PTPRZ1

5.23e-0617411269e5fae9ecc7c0111fc8a252e72b89dc89c0d3a7c
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-3|TCGA-Cervix / Sample_Type by Project: Shred V9

DSC3 IFI16 FAT2 INAVA CRYBG3 PGM2

5.40e-0617511260cc215109d9915af47e4d0a120ce2e46910715fa
ToppCell5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SYNPO2 DYSF RGMA KLF10 RBPMS2 PALLD

7.90e-061871126e1b41560c26795a7d353b9468b1bb6fc7c6b379e
ToppCellfacs-Trachea-nan-3m-Epithelial-basal_epithelial_cell_of_tracheobronchial_tree|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERN2 ESRP2 FAT2 PTPRZ1 INAVA PLXNB1

7.90e-061871126fe9fc21192ede2eea61f419d20ccda254569d0a6
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial-respiratory_basal_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ERN2 ESRP2 FAT2 PTPRZ1 INAVA PLXNB1

8.14e-0618811268ffb5394f7b00ea483a5fe4df894d22fda935e5c
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_trachea|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ERN2 ESRP2 FAT2 PTPRZ1 INAVA PLXNB1

8.14e-061881126137ed9958044fab7a13648affb469585d1c48cf6
ToppCellNasal_Brush|World / Tissue, Lineage and Cell class of Lung Cells from 10X

TMEM54 MUC16 ERN2 IFI16 GPT2 SORD

1.00e-0519511267509b980b6b293df02bec619ef5b83a6c7b49c03
ToppCelldistal-Epithelial-Differentiating_Basal-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TMEM54 CMYA5 LMTK3 ERN2 FAT2 PTPRZ1

1.00e-0519511263fe6e49a9161fc9e5160251e6932cb5378175a54
ToppCellEpithelial_cells-Club_cells|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

MUC16 ERN2 IFI16 PTPRZ1 INAVA SORD

1.00e-051951126b758676abfc4e6930b696d270ecc0ea461b87a54
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DSC3 TMEM54 ARHGEF5 MUC16 FAT2 INAVA

1.00e-05195112624d226f89dd337c22728688e4b40ca082a0e1fe1
ToppCelldistal-Epithelial-Proximal_Basal|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DSC3 LMTK3 ERN2 FAT2 PTPRZ1 INAVA

1.03e-051961126c102b28d5d1d90b9f7024cb51114276354be26a5
ToppCelldistal-Epithelial-Proximal_Basal-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DSC3 LMTK3 ERN2 FAT2 PTPRZ1 INAVA

1.03e-051961126a543d4623096cb3f9170dbf7af52381e77aa435e
ToppCelldistal-3-Epithelial-Proximal_Basal|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DSC3 LMTK3 ERN2 FAT2 PTPRZ1 INAVA

1.03e-0519611267e1a565dd2da4f375cbce8842ba4fd6c22ac8375
ToppCellNS-moderate-d_07-13-Epithelial-Secretory|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TMEM54 CMYA5 ERN2 PTPRZ1 INAVA SORD

1.03e-05196112647930de6b47b7bf22d8dae8b7419a9cd1d22f0ea
ToppCell367C-Epithelial_cells-Epithelial-H_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DSC3 FOSB IFI16 FOSL1 FAT2 PTPRZ1

1.03e-051961126e8db58e82300981f981402618a1befb91f6690fd
ToppCell367C-Epithelial_cells-Epithelial-H_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DSC3 FOSB IFI16 FOSL1 FAT2 PTPRZ1

1.03e-0519611262cf42b702ea15adfa6bbd86a3c9613271863f86c
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DSC3 ARHGEF5 FOSL1 FAT2 PTPRZ1 INAVA

1.06e-051971126233b9fcb376e08d0080a05ca0198ecc6ec720f90
ToppCell10x5'-Liver-Lymphocytic_T_CD4|Liver / Manually curated celltypes from each tissue

PDE3B BATF FOSB ETS1 AHR ZC3HAV1

1.06e-0519711264891111894b741555f549deec6af8006376d9358
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DSC3 LGR4 MUC16 ERN2 FAT2 PTPRZ1

1.06e-051971126107cb153ea7fc74bbd244dbb9d0499c0a8506724
ToppCelldistal-Epithelial-Basal-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DSC3 ABCA12 TMEM54 TMEM171 FAT2 INAVA

1.06e-05197112675b4292ce2ad7f9c8b6a4781e1cb71f5b18b74e3
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DSC3 LGR4 MUC16 ERN2 FAT2 PTPRZ1

1.09e-05198112628ada093cec552262731194a04a4b9ff93186c3b
ToppCellcellseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Suprabasal|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DSC3 MUC16 ERN2 FAT2 PTPRZ1 INAVA

1.09e-0519811266e047de63ef59dcb47e4fc06b173b2a02fdcf4c9
ToppCellEpithelial_cells-Basal_cells|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

LGR4 GCNT1 IFI16 FAT2 PTPRZ1 PALLD

1.09e-0519811264235005c49fc2b29ad3a0ee6b608f0109d04f775
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DSC3 ARHGEF5 FOSB FOSL1 FAT2 PTPRZ1

1.09e-051981126fc00cb25cdc6c31b7f9d397bc9f9a8f4e9708003
ToppCellPSB-critical-LOC-Epithelial-Basal|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DSC3 CMYA5 IFI16 FAT2 HMCN1 PTPRZ1

1.13e-0519911262add64c3e4cb6384ec381f34c3f1f77e13e3f27c
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM54 ERN2 FAT2 PTPRZ1 INAVA SORD

1.13e-051991126fbd39d34636137d1b877dd8815d58f124990136b
ToppCellNS-control-d_0-4-Epithelial-Secretory|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CMYA5 ERN2 IFI16 FAT2 PTPRZ1 SORD

1.13e-05199112632bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM54 ERN2 FAT2 PTPRZ1 INAVA SORD

1.13e-0519911266977f939ddbc47d4921f36c0a61a205259fe1284
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DSC3 TMEM54 TMEM171 FAT2 PTPRZ1 INAVA

1.13e-051991126ba284f984909504221900bca5ea12ada5b2ffd9f
ToppCellcontrol-Epithelial-Secretory|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CMYA5 ERN2 IFI16 FAT2 PTPRZ1 SORD

1.13e-0519911263d01f90ffd271ca00129192787e4921bdca7e01e
ToppCellcontrol-Epithelial-Secretory|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CMYA5 ERN2 IFI16 FAT2 PTPRZ1 SORD

1.13e-051991126262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCellBiopsy_Control_(H.)-Epithelial-MUC5AC+_High|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

MUC16 ERN2 FAT2 PTPRZ1 ITIH6 CDH12

1.13e-051991126a5240868cea40574ed4ee45eb27a00c1812957ed
ToppCellcontrol|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DSC3 ARHGAP5 FAT2 PTPRZ1 PALLD PLXNB1

1.16e-05200112697f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCellControl_saline-Endothelial-Endothelial-Gen_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

PITPNM2 PDE3B ETS1 DYSF IFI16 AHR

1.16e-0520011263b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_basal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DSC3 ARHGEF5 FOSL1 FAT2 PTPRZ1 SORD

1.16e-0520011262a9d715aba8bdef2341b0d44ff60825c074a4b03
ToppCellNS-control|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MUC16 ARHGAP5 FAT2 PTPRZ1 PALLD PLXNB1

1.16e-052001126ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCellCOVID-19_Mild-Neu_0|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients

RNPEPL1 RUBCNL TRAK1 ZC3HAV1

1.94e-056311241ab77b6f098686bc168427159282bbf3538d4292
ToppCellLPS_only-Myeloid-Dendritic_cells-pDC|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DSC3 RUBCNL ITIH6 BOLL PLD4

2.34e-0513511250afe232aa1a1e6c37a5b3183b67d7fa07e0ea791
ToppCellChildren_(3_yrs)-Epithelial-basal_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ABCA12 FOSB LGR4 FAT2 PTPRZ1

3.09e-05143112528e936c298a45f88d14f0146caf3d5a22d483cd5
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Myeloid-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BATF DALRD3 GPT2 PIK3R5 PLD4

3.41e-05146112569cbe8d4772f8e46a5e1a1cdca0e370308a97b4f
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

IQCH EXD1 ABCA12 CMYA5 ADGRG2

3.76e-051491125c5eedb54ef2e0f131aa6730612c921bc19479632
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_granulocytic|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

IQCH EXD1 ABCA12 CMYA5 ADGRG2

3.76e-051491125a22417286de8606f0cc94f86b70bce17aeefb9c2
ToppCellCOVID-Treg-CD4_Treg|COVID / Condition, Cell_class and T cell subcluster

IQCH BATF ARHGEF5 ETS1 MUC12

4.26e-05153112547c649fd4231e507f2d4654ccac61faf21a04eff
ToppCellLPS-IL1RA+antiTNF-Myeloid-Dendritic_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DSC3 RUBCNL TMEM171 FAT2 PLD4

4.26e-051531125c81a88d3f707487c511020d3960a1c41e706c6a0
ToppCellControl-B_naive-1|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ELOA RUBCNL ENTR1 ETS1 FAM53B

4.53e-0515511250a78d1cab2bdba2dc8a74cdf35b5a0192370c4b5
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

COL6A1 EXD1 CDKL5 SACS PLD4

4.68e-051561125a5930b455e5c8586c43c50106ab4d8a1e5e9e3d6
ToppCell343B-Epithelial_cells-Epithelial-H_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DSC3 LGR4 FAT2 HMCN1 PTPRZ1

5.43e-051611125da9eecf919866a9c579d7a707a996cf335213134
ToppCell343B-Epithelial_cells-Epithelial-H_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DSC3 LGR4 FAT2 HMCN1 PTPRZ1

5.43e-051611125d431625c32f59a6b552191f3adc5198bd16ad5cf
ToppCellStriatum-Neuronal-Inhibitory-iN2(Gad1Gad2)|Striatum / BrainAtlas - Mouse McCarroll V32

C15orf62 EXD1 ERN2 SOX14

6.02e-058411249417fffe0ba79f5851920258dcd0f6c09218be13
ToppCell367C-Lymphocytic-NK_cells-NK_cell_E|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

C15orf62 FOSB PPP2R3B PITPNM1 AHR

6.46e-051671125b5d15773be32cd277125fd3b4056a8fefaefa5ec
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Microglia/Mac|Myeloid_cells / Location, Cell class and cell subclass

NRDE2 TMEM201 GRIN2D LMTK3 ERN2

6.83e-051691125dba8f5599aa21feef5b7fdfed2e3ab54748d80f7
ToppCellControl-T_cells-Tregs|Control / group, cell type (main and fine annotations)

PDE3B BATF ETS1 IFI16 ZC3HAV1

6.83e-051691125e1e0983f31ec81b3fad5f9c6140d17f03f81a5dc
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LGR4 MUC16 ERN2 AMOT INAVA

6.83e-05169112540b557549fe08c5dc9dba359af35993d68d1640a
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_104|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A1 SYNPO2 FOSB TNS2 PALLD

6.83e-0516911256ff1172da690ca17f7108f1617b255b766971a57
ToppCell15-Airway-Epithelial-Club-like_secretory|Airway / Age, Tissue, Lineage and Cell class

MUC16 LMTK3 ESRP2 ADGRG2 INAVA

7.03e-0517011251418031cc4b4a87a48621eb53a3c819cd713ddd0
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Granulocytic-Mast_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3B BMP2K ABCA12 FOSB PITPNM1

7.23e-051711125ac37c80c832504986c7a201d84f4b6aff5e5f323
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Granulocytic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3B BMP2K ABCA12 FOSB PITPNM1

7.23e-051711125b6502a81df4f25660f3ae4b7443a1d999df2d32b
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 ERN2 TRAK1 AMOT SORD

7.84e-05174112542f2ba54b4ea4c62482582b0ccdadffae0a5eb4a
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MUC16 PITPNM1 TMEM171 FAT2 PLXNB1

7.84e-051741125207aa0118633cbe9a65839bbb1bb3ba9f8118ad2
ToppCellP03-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

COL6A1 ETS1 ZYX AHR PALLD

8.06e-051751125282f09bbdfa70d93b3f66591dcfb84c5ee0268c7
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LGR4 ASPHD2 SH2B2 FOSL1 XPO7

8.06e-051751125085cceb1fc2c4ae2f27e85cea5702defecc2cf44
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LGR4 GRIN2C PTPRZ1 PGM2 PLXNB1

8.28e-051761125ac3dc44755280e36c0947b6de3cd639dc17de8b6
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TENT4A BATF ETS1 PITPNM1 FAM53B

8.50e-051771125d5503605d46a335cc7ca1f94626809f9e1b505e2
ToppCellwk_20-22-Epithelial-Proximal_epithelial-basal_proximal|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

DSC3 TMEM54 FAT2 PTPRZ1 CDH12

8.73e-0517811259534c4f4e950bb1498c1737ca1713e7f37d0aff2
ToppCell368C-Myeloid-Dendritic-cDC_proliferating_1|368C / Donor, Lineage, Cell class and subclass (all cells)

APBA1 AMOT GPT2 ARHGAP33 XPO7

8.96e-051791125ec69e1dd897414033ba5b007aa82655a79adca6c
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DSC3 ERN2 FAT2 AHR INAVA

9.69e-051821125678eadd57e7e830fc2bf9fd35616d3badce01705
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DSC3 ERN2 FAT2 AHR INAVA

9.69e-0518211258d1229fa5aa6e2e38f2ac6fe4f4dc89752fe9344
ToppCellAdult-Epithelial-basal_cell|Adult / Lineage, Cell type, age group and donor

DSC3 LGR4 FAT2 HMCN1 PTPRZ1

9.94e-05183112500a6b19ca49e3b8e0d1cd387a3515b0ff4b81c81
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM54 LGR4 CMYA5 LMTK3 ERN2

9.94e-0518311252dde2fb48e7d31271c2f6b1dd74b2ab0b2cb520c
ToppCellB_cells-ABCs|B_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

BMP2K BATF ZYX PIK3R5 PLD4

9.94e-051831125bf9c6fe3ce4e44e4056027257eab8448c39c4fb8
ToppCell3'-Child04-06-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SYNPO2 IQCH RGMA RBPMS2 PALLD

1.02e-041841125590fb32bb1f348ea5fa2aece30ebe1e212512991
ToppCellControl-T_cells-CD8+_T_cells|Control / group, cell type (main and fine annotations)

PDE3B ETS1 LINC00612 PIK3R5 ZC3HAV1

1.05e-04185112502ab64c0166c0646d1d4c6ed110ef0b75a1096d0
ToppCellControl-Epithelial-Basal|Epithelial / Disease state, Lineage and Cell class

DSC3 IFI16 FOSL1 FAT2 PTPRZ1

1.05e-041851125d5d6d13e2f20b54ca55645b9a757b8599f4fd897
ToppCell368C-Myeloid-Dendritic-cDC_proliferating_1|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

APBA1 AMOT GPT2 ARHGAP33 XPO7

1.07e-041861125799903b68bc6f6205d004b44c603424b0d5f7c32
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ERN2 FAT2 PTPRZ1 INAVA PLXNB1

1.07e-04186112537b93ebd64ebbd08193a746e5bc9b350c2570733
ToppCellCOPD-Myeloid-Mast|COPD / Disease state, Lineage and Cell class

BMP2K BATF FOSB AHR PALLD

1.07e-041861125def6f0f284acc2154738574c8c5d3d2a5ef1f208
ToppCell368C-Myeloid-Dendritic-cDC_proliferating_1|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

APBA1 AMOT GPT2 ARHGAP33 XPO7

1.07e-0418611255cadab3271fce9ab6da3d7ba9827b8a221cac166
ToppCellControl-T_cells|Control / group, cell type (main and fine annotations)

PDE3B ETS1 IFI16 PIK3R5 ZC3HAV1

1.10e-041871125f4e8e0eba58da89b56587667555a5d4754e108c7
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SYNPO2 ZYX RGMA RBPMS2 PALLD

1.10e-0418711253912bbb610a4a84791e9bda92a2d57a52c31d29e
ToppCellCOVID-19-Epithelial_cells-Airway_basal|COVID-19 / group, cell type (main and fine annotations)

DSC3 LGR4 FAT2 PTPRZ1 PLXNB1

1.10e-0418711258407a82e98f56a94ea26562bcb6bbe00a8f41661
ToppCellfacs-Lung-EPCAM-18m-Epithelial-Basal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSC3 FAT2 PTPRZ1 INAVA PLXNB1

1.16e-041891125783c1db856f2defe6f3b8748dd0bc29a8102f6d1
ToppCell3'-Adult-Distal_Rectal-Mesenchymal-Pericytes|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SYNPO2 TNS2 STARD9 RBPMS2 PALLD

1.16e-041891125d69b7a01dd4d6ad043bb6210e9ab34b49578389c
ToppCell3'-Adult-Distal_Rectal-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SYNPO2 TNS2 STARD9 RBPMS2 PALLD

1.16e-0418911252b5f1b4f173a224342ea4f10b193ee33b7662699
ToppCell3'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL6A1 SYNPO2 RGMA RBPMS2 PALLD

1.16e-04189112563449d9f1e78ff2bc8786eb88a0d177fe30c7f4d
ToppCellfacs-Lung-EPCAM-18m-Epithelial-respiratory_basal_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSC3 FAT2 PTPRZ1 INAVA PLXNB1

1.16e-04189112588b72fafbe58463543e0818f27f3dd9e5b4d34d2
ToppCell3'-Adult-Distal_Rectal-Mesenchymal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SYNPO2 TNS2 STARD9 RBPMS2 PALLD

1.16e-04189112543e131458d8a4b120f7a5fb3d0c5650abded15f6
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-respiratory_basal_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DSC3 FAT2 PTPRZ1 INAVA PLXNB1

1.19e-04190112547e07ea22733306d8885ee9e5f0b033e2f5e2afb
Drug9-nitrophenanthrene

AHR GPT2 SORD

1.12e-0651113CID000070382
DrugMethimazole [60-56-0]; Down 200; 35uM; PC3; HT_HG-U133A

SETD1A ABCA2 CPT2 ERN2 TRAK1 HPS1 ELL ARHGAP33

4.47e-0619111183815_DN
DrugPilocarpine nitrate [148-72-1]; Up 200; 14.8uM; MCF7; HT_HG-U133A

ABCA2 ABCA12 ERN2 ZYX TRAK1 HPS1 FAM53B ARHGAP33

5.41e-0619611185341_UP
DrugThioproperazine dimesylate [2347-80-0]; Up 200; 6.2uM; MCF7; HT_HG-U133A

COL6A1 ABCA2 DSC3 CASP9 GCNT1 TRAK1 ADGRG2 PLXNB1

5.62e-0619711186265_UP
DrugBezafibrate [41859-67-0]; Down 200; 11uM; HL60; HT_HG-U133A

BMP2K FOSB CPT2 DALRD3 AHR FAM53B ANKRD40 ZC3HAV1

5.83e-0619811181275_DN
Drugiododimethylarsine

FOSB RNF34 FOSL1

9.27e-0691113CID000069608
Drugaptiganel

FOSB GRIN2C GRIN2D FOSL1

1.00e-05281114CID000060839
DrugRaimondal

ABCA12 BOLL

2.36e-0521112CID000156741
DrugAgmatine

FOSB GRIN2C GRIN2D

3.11e-05131113ctd:D000376
Drugmethyloxoarsine

FOSB RNF34 FOSL1

3.95e-05141113CID000092815
Drug1h08

TMEM54 FOSB FOSL1

4.92e-05151113CID000445957
Drug0179445-0000 [211246-22-9]; Down 200; 1uM; MCF7; HT_HG-U133A

COL6A1 TNS2 ERN2 TRAK1 ADGRG2 AHR ARHGAP33

5.02e-0519611173633_DN
DrugAspartic acid, N-acetyl (R,S) [997-55-7]; Down 200; 22.8uM; MCF7; HT_HG-U133A

COL6A1 ABCA2 TNS2 ERN2 DYSF ADGRG2 ELL

5.02e-0519611174125_DN
DrugFoliosidine [2520-38-9]; Down 200; 13uM; MCF7; HT_HG-U133A

ABCA2 DSC3 BMP2K ZYX TRAK1 ZNF592 HPS1

5.02e-0519611176057_DN
DrugSulfaphenazole [526-08-9]; Down 200; 12.8uM; MCF7; HT_HG-U133A

BMP2K SNX19 TRAK1 FOSL1 ZNF592 HPS1 FAM53B

5.19e-0519711175507_DN
DrugN-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Down 200; 25.2uM; MCF7; HT_HG-U133A

COL6A1 ABCA2 DSC3 BMP2K DYSF ADGRG2 PLXNB1

5.36e-0519811176031_DN
DrugJosamycin [16846-24-5]; Down 200; 4.8uM; MCF7; HT_HG-U133A

PDE3B BMP2K TNS2 CPT2 DALRD3 TRAK1 PITPNM1

5.36e-0519811171534_DN
Drug(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Down 200; 11.8uM; MCF7; HT_HG-U133A

COL6A1 ABCA2 DSC3 DYSF ADGRG2 HPS1 ELL

5.36e-0519811176053_DN
Drug5194442; Down 200; 20uM; MCF7; HT_HG-U133A

PDE3B ABCA2 RNPEPL1 CASP9 ERN2 ADGRG2 ZC3HAV1

5.36e-0519811176599_DN
DrugHippeastrine hydrobromide [22352-41-6]; Down 200; 10uM; MCF7; HT_HG-U133A

COL6A1 DSC3 BMP2K ERN2 DYSF ADGRG2 ELL

5.36e-0519811176042_DN
DrugMolsidomine [25717-80-0]; Down 200; 16.6uM; MCF7; HT_HG-U133A

PDE3B BMP2K RNPEPL1 TNS2 FOSL1 C2CD3 HPS1

5.53e-0519911172862_DN
DrugDipyridamole [58-32-2]; Down 200; 8uM; MCF7; HT_HG-U133A

SETD1A ABCA2 BMP2K ZYX TRAK1 ELL PLXNB1

5.53e-0519911175617_DN
DrugMetrizamide [31112-62-6]; Down 200; 5uM; HL60; HT_HG-U133A

BMP2K CASP9 DYSF FOSL1 PITPNM1 ANKRD40 PRRC2A

5.53e-0519911171318_DN
DrugBumetanide [28395-03-1]; Down 200; 11uM; MCF7; HT_HG-U133A

PDE3B ABCA2 CASP9 TRAK1 ADGRG2 PIK3R5 ARHGAP33

5.53e-0519911175542_DN
DrugIobenguane sulfate; Down 200; 10.8uM; MCF7; HT_HG-U133A

SETD1A ABCA2 ERN2 DALRD3 FOSL1 HPS1 PRRC2A

5.53e-0519911172878_DN
DrugPerylene

FOSL1 AHR

7.04e-0531112ctd:D010569
Drug1,2,3-trichloropropane

APBA1 AHR SORD

7.30e-05171113CID000007285
Diseasecreatinine measurement

SLC7A13 ETS1 CASP9 SH2B2 CDKL5 USP10 TMEM171 ZNF592 AHR FAM53B BSN ELL SORD

8.71e-0599511013EFO_0004518
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

GRIN2C GRIN2D PLXNB1

8.20e-04491103DOID:0060037 (implicated_via_orthology)
Diseaseamyotrophic lateral sclerosis (biomarker_via_orthology)

CASP9 PTPRZ1

1.05e-03131102DOID:332 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
PSPYPTTSSLEDFVT

AHR

726

P35869
CTYPNLLDSPSFPED

GPT2

116

Q8TD30
SSASYQPVPADPFAI

AMOT

416

Q4VCS5
PQPDCPAEARTFSFY

ELL

66

P55199
PSTSQEDLYFSVPPT

AGAP11

61

Q8TF27
EDLYFSVPPTANTPT

AGAP11

66

Q8TF27
ASPTNPTAISPEEYF

ANKRD13D

321

Q6ZTN6
SPPPSFCLEYTSAIF

CRYBG3

716

Q68DQ2
PSPSSDLEIPGTYTF

ABCA12

141

Q86UK0
PSASSAPFLYLQPSE

BOLL

201

Q8N9W6
SPAEAYPITPASVSA

ARHGEF5

521

Q12774
ATSFAEPPDYSPVTH

ADGRG2

276

Q8IZP9
TSPSPYAFSPVISDF

ARGFX

161

A6NJG6
NPAFPFIYTPTAEDS

ANKRD40

126

Q6AI12
YNLSPSIFFCATPPD

SORD

111

Q00796
SPEYLTSPQEFSPAL

BMP2K

561

Q9NSY1
SPLPLVTASSAYAFP

AGBL1

271

Q96MI9
ILSDSSPAPEFPLAY

CPT2

276

P23786
SPAPEFPLAYLTSEN

CPT2

281

P23786
SPTSAEYIPLTPAAA

GMEB2

191

Q9UKD1
APYPLYTTELTPAIS

RBPMS2

156

Q6ZRY4
TSPYPETDSAFFEPS

RUBCNL

156

Q9H714
PLPPATSQSIPTFYF

PPP2R3B

116

Q9Y5P8
VLPSSHCTDPYFTPI

IQCH

146

Q86VS3
GPSSLEPCFESYISF

KRT76

226

Q01546
PSLESYSSSPCPAVA

MSGN1

51

A6NI15
SPHFTALYSSVPFPE

POU5F1B

326

Q06416
SPNEFYFTVSPDSDP

MUC16

6311

Q8WXI7
FPTLSETPYEPETTA

MUC16

11561

Q8WXI7
VPCIFVYTRPPSAFS

OR4C15

251

Q8NGM1
EVTSCYFPIDFTPPP

MMS19

216

Q96T76
LYPPSAEYATTSPLE

LRRC53

1231

A6NM62
ASESLFLPYYPPDSE

ERN2

901

Q76MJ5
SSDSPPDIFSFVPYT

KIAA1109

506

Q2LD37
FPQETRVSPSDTFYP

EXD1

471

Q8NHP7
SNPFYEALSTPSVLP

LMTK3

511

Q96Q04
VESDLASYPPPAVSS

BSN

3381

Q9UPA5
FSFVEYCPPSANSTP

FAM53B

236

Q14153
PPSEFSEPSFITESY

ETS1

171

P14921
TLNPTPFSYEADPTL

PLXNB1

1366

O43157
PLFSPPSYRVTISED

FAT2

146

Q9NYQ8
FSEPLYTFSAPEDLP

FAT2

2691

Q9NYQ8
LTPFPGFYPCSEIED

PDE3B

401

Q13370
VPSGFTPPASCLYLA

NRDE2

646

Q9H7Z3
YLFSDITPTPFVPFT

PGM2

136

Q96G03
EYSASPLCLPFPTGE

LGR4

686

Q9BXB1
PYIPDVSSPSDTSNF

CDC42BPB

356

Q9Y5S2
FAYFPTEVTPHAFTP

PTPRZ1

716

P23471
YCPDALTAFPTVALP

PITPNM2

926

Q9BZ72
DSDTPPCTTPSVYQF

TENT4A

601

Q5XG87
SPTSLVCEAYSYPPA

HMCN1

2591

Q96RW7
DPFPVVNPSYTSSFV

FOSB

291

P53539
PDGTTTAYFPPVFTK

PALLD

431

Q8WX93
TTAYFSASPPALCPQ

PLD4

301

Q96BZ4
AFFYFESCQPPSPAL

NPY6R

21

Q99463
SPDFLLSYPPAPSCF

ARHGAP33

1131

O14559
EVFFLPDLPTTPYFS

ASPHD2

166

Q6ICH7
SLIPIYSPFSFPASD

C2CD3

1786

Q4AC94
APFYFSLPNTSPEIS

DSC3

606

Q14574
PDYTCPITFSSPADI

COL6A1

816

P12109
ASSISFNPSPEEPAY

ELOA

736

Q14241
YLSFFSTPSELAGPE

ENTR1

211

Q96C92
LAASTPSPPEVVYSA

BATF

96

Q16520
PTPSDIFVSYSTFPG

CASP9

336

P55211
SPDSAFVSEFSFPPY

CMYA5

946

Q8N3K9
FDLPAYTSPTNFPAV

ABCA2

1861

Q9BZC7
SLASFPTYVEVPGPC

APBA1

436

Q02410
LPYPSEASTTFPESH

IFI16

411

Q16666
SLNPPAFYTFLTPDE

ITIH6

1021

Q6UXX5
TIPAFCLTPPYSPSD

KLF10

86

Q13118
YPTFPPVSSLDFSLL

DALRD3

426

Q5D0E6
VDPTAPPYDSLATYA

CDH12

726

P55289
PPLETPLFSGSAYFV

GCNT1

276

Q02742
SYAPFTLFPSLVPSA

GSS

46

P48637
TDSFSLPEEYFTPAP

HPS1

291

Q92902
YFPSSCLDLNSPTSP

CDKL5

516

O76039
TYFPPSVFTSPDILH

SACS

1071

Q9NZJ4
ESFLCDPYSAESPSP

DYSF

1426

O75923
PTHYTVTVPDSCFPA

INAVA

426

Q3KP66
LTPFTPSLVFTYPST

FOSL1

226

P15407
PSLVFTYPSTPEPCA

FOSL1

231

P15407
FAPCSAFLSPVPYFE

OTOG

721

Q6ZRI0
PFTDYGSSLTVTLPP

RNPEPL1

141

Q9HAU8
SGKSLPCFEPYEFTP

POLR1A

931

O95602
SFLYSPAFCPSPLPD

PRRC2A

1926

P48634
SEDVFLPSPRDCFPY

ARHGAP5

961

Q13017
FLPPSSQPEESYCLV

STARD9

3841

Q9P2P6
CLSPPTYTTFQATPT

ESRP2

581

Q9H6T0
SPAPTAPETFPYETA

RGMA

346

Q96B86
PFAENTAERFPPSYT

SETD1A

396

O15047
SACPSVPDYTASPPA

LINC00612

56

Q8N6U2
LEPPPAYTAAYSATL

C15orf62

96

A8K5M9
CTSPPYDNFLASKPA

TRAK1

801

Q9UPV9
LAECEEPSIYSPAFP

PITPNM1

886

O00562
ADIYSFSELPTPDTP

URGCP

166

Q8TCY9
VPANPDSFFPRCYSL

TTLL8

181

A6PVC2
LAPDCPFDPTRIYSS

TMEM54

141

Q969K7
SIPILCSYFFDEGPP

RBP3

1091

P10745
SVPAYTSPPSFFAEA

SYNPO2

1026

Q9UMS6
YSTVLCTPHFPPDSD

PIK3R5

86

Q8WYR1
FTPNPEFSTYPPAAT

RNF34

41

Q969K3
GYCTEDSPSFPRPSL

ZNF592

1046

Q92610
YFSSLAAAACPPASP

SH2B2

546

O14492
AEYSIQPFFPSCSVP

SLC7A13

116

Q8TCU3
PVSDYFSLLSGSCPS

TMEM201

486

Q5SNT2
PYFPESSASAVAESP

TMEM171

226

Q8WVE6
SPVAAPVFLSYSEPE

SNX19

306

Q92543
IPFLTESYSSSQDPP

UBA1

611

P22314
FDLYHSIPPSFSPLV

XPO7

266

Q9UIA9
PSPAISVSVSAPAFY

ZYX

6

Q15942
FFVTPRSSVELPPYS

USP10

21

Q14694
FPLPVVPDYSSSTYL

USP30

421

Q70CQ3
TYTSPPPQFDSCVDT

ZC3HAV1

856

Q7Z2W4
PASAPYSLLDPAQFS

SOX14

131

O95416
CPSEPYFGSLSALVS

TNS2

1216

Q63HR2
DLVGEPTTFYISPSP

MUC12

5071

Q9UKN1
TVSPSAFLEPYSPAV

GRIN2C

541

Q14957
TVSPSAFLEPYSPAV

GRIN2D

571

O15399