Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	inhibitory MHC class I receptor activity	LILRA3 LILRB1	2.30e-04	12	38	2	GO:0032396
GeneOntologyMolecularFunction	MHC class I receptor activity	LILRA3 LILRB1	5.29e-04	18	38	2	GO:0032393
GeneOntologyMolecularFunction	MHC class Ib receptor activity	KLRK1 LILRB1	5.91e-04	19	38	2	GO:0032394
GeneOntologyMolecularFunction	MHC class I protein binding	KLRK1 LILRB1	1.69e-03	32	38	2	GO:0042288
GeneOntologyMolecularFunction	protein-membrane adaptor activity	SPTBN4 RRAGC	3.32e-03	45	38	2	GO:0043495
GeneOntologyMolecularFunction	immune receptor activity	KLRK1 LILRA3 LILRB1	3.78e-03	165	38	3	GO:0140375
Domain	-	CNTNAP5 MYCBP2 EPHA10	4.38e-04	73	38	3	2.60.120.260
Domain	-	IFT122 UNC45A COA7 CTR9	8.05e-04	207	38	4	1.25.40.10
Domain	Galactose-bd-like	CNTNAP5 MYCBP2 EPHA10	9.17e-04	94	38	3	IPR008979
Domain	TPR-like_helical_dom	IFT122 UNC45A COA7 CTR9	1.25e-03	233	38	4	IPR011990
Domain	EGF_2	MASP1 CNTNAP5 F12 EPHA10	2.00e-03	265	38	4	PS01186
Domain	DnaJ	DNAJC24 DNAJC13	4.29e-03	48	38	2	PF00226
Domain	ZINC_FINGER_C2H2_2	TSHZ1 ZNF30 ZNF268 ZNF730 ZNF441 ZNF345	4.44e-03	775	38	6	PS50157
Domain	DnaJ	DNAJC24 DNAJC13	4.46e-03	49	38	2	SM00271
Domain	DNAJ_1	DNAJC24 DNAJC13	4.46e-03	49	38	2	PS00636
Domain	DNAJ_2	DNAJC24 DNAJC13	4.46e-03	49	38	2	PS50076
Domain	-	DNAJC24 DNAJC13	4.46e-03	49	38	2	1.10.287.110
Domain	ZINC_FINGER_C2H2_1	TSHZ1 ZNF30 ZNF268 ZNF730 ZNF441 ZNF345	4.50e-03	777	38	6	PS00028
Domain	TPR_2	UNC45A CTR9	4.64e-03	50	38	2	PF07719
Domain	TPR_2	UNC45A CTR9	4.64e-03	50	38	2	IPR013105
Domain	DnaJ_domain	DNAJC24 DNAJC13	4.83e-03	51	38	2	IPR001623
Domain	Sushi	MASP1 APOH	5.01e-03	52	38	2	PF00084
Domain	Znf_C2H2-like	TSHZ1 ZNF30 ZNF268 ZNF730 ZNF441 ZNF345	5.06e-03	796	38	6	IPR015880
Domain	TPR_8	UNC45A CTR9	5.20e-03	53	38	2	PF13181
Domain	Znf_C2H2	TSHZ1 ZNF30 ZNF268 ZNF730 ZNF441 ZNF345	5.34e-03	805	38	6	IPR007087
Domain	CCP	MASP1 APOH	5.40e-03	54	38	2	SM00032
Domain	ZnF_C2H2	TSHZ1 ZNF30 ZNF268 ZNF730 ZNF441 ZNF345	5.44e-03	808	38	6	SM00355
Domain	SUSHI	MASP1 APOH	5.79e-03	56	38	2	PS50923
Domain	KRAB	ZNF30 ZNF268 ZNF730 ZNF441	5.86e-03	358	38	4	PS50805
Domain	KRAB	ZNF30 ZNF268 ZNF730 ZNF441	5.86e-03	358	38	4	PF01352
Domain	Sushi_SCR_CCP_dom	MASP1 APOH	6.00e-03	57	38	2	IPR000436
Domain	KRAB	ZNF30 ZNF268 ZNF730 ZNF441	6.51e-03	369	38	4	SM00349
Domain	KRAB	ZNF30 ZNF268 ZNF730 ZNF441	6.58e-03	370	38	4	IPR001909
Domain	CH	SPTBN4 VAV1	7.73e-03	65	38	2	SM00033
Domain	CH	SPTBN4 VAV1	8.92e-03	70	38	2	PF00307
Domain	-	SPTBN4 VAV1	9.17e-03	71	38	2	1.10.418.10
Domain	CH	SPTBN4 VAV1	9.67e-03	73	38	2	PS50021
Domain	Ig_2	LILRA3 LILRB1	9.67e-03	73	38	2	PF13895
Domain	CH-domain	SPTBN4 VAV1	1.02e-02	75	38	2	IPR001715
Domain	-	ZNF30 ZNF268 ZNF730 ZNF441 ZNF345	1.16e-02	679	38	5	3.30.160.60
Domain	EGF_3	MASP1 CNTNAP5 F12	1.20e-02	235	38	3	PS50026
Pathway	REACTOME_SYNTHESIS_OF_PYROPHOSPHATES_IN_THE_CYTOSOL	NUDT3 IP6K3	2.08e-04	10	31	2	MM14709
Pathway	REACTOME_SYNTHESIS_OF_PYROPHOSPHATES_IN_THE_CYTOSOL	NUDT3 IP6K3	2.08e-04	10	31	2	M27051
Pubmed	The effect of LILRB1 but not LILRA3 gene polymorphism in immunopathology of ankylosing spondylitis-A parallel to KIR genes.	LILRA3 LILRB1	1.16e-06	2	38	2	30892832
Pubmed	Dynamic shift from CD85j/ILT-2 to NKG2D NK receptor expression pattern on human decidual NK during the first trimester of pregnancy.	KLRK1 LILRB1	1.16e-06	2	38	2	22242197
Pubmed	Inhibition of the activation of Hageman factor (factor XII) by beta 2-glycoprotein I.	APOH F12	1.16e-06	2	38	2	3361230
Pubmed	Spatially resolved in silico modeling of NKG2D signaling kinetics suggests a key role of NKG2D and Vav1 Co-clustering in generating natural killer cell activation.	KLRK1 VAV1	1.16e-06	2	38	2	35584138
Pubmed	LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1/LILRB2: structural evidence.	LILRA3 LILRB1	6.96e-06	4	38	2	21559424
Pubmed	NKG2D-DAP10 signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity.	KLRK1 VAV1	6.96e-06	4	38	2	31235500
Pubmed	HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding.	LILRA3 LILRB1	6.96e-06	4	38	2	21270408
Pubmed	A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells.	LILRA3 LILRB1	6.96e-06	4	38	2	9382880
Pubmed	Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics.	KLRK1 VAV1	1.16e-05	5	38	2	16887996
Pubmed	Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways.	LILRA3 LILRB1	1.74e-05	6	38	2	9079806
Pubmed	A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.	LILRA3 LILRB1	3.24e-05	8	38	2	9548455
Pubmed	Transcriptional Repression of Aerobic Glycolysis by OVOL2 in Breast Cancer.	MLH1 DDX17 UNC45A	1.55e-04	95	38	3	35896951
Pubmed	Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid.	APOH F12	1.76e-04	18	38	2	16199891
Pubmed	A novel miR1983-TLR7-IFNβ circuit licenses NK cells to kill glioma cells, and is under the control of galectin-1.	KLRK1 TLR5	1.96e-04	19	38	2	34249474
Pubmed	Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.	ZNF268 ZNF345	2.41e-04	21	38	2	7865130
Pubmed	ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.	MLH1 DDX17 SOCS6 CTR9	4.87e-04	336	38	4	31253590
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	MLH1 DNAJC13 DDX17 UNC45A MYCBP2 CTR9 MAT2A	5.81e-04	1353	38	7	29467282
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	DNAJC13 DDX17 UNC45A CTR9 MAT2A	6.22e-04	638	38	5	33239621
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	SPTBN4 DNAJC24 DNAJC13 MYCBP2	6.38e-04	361	38	4	26167880
Pubmed	Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.	MLH1 DDX17 MYCBP2	1.01e-03	180	38	3	21139048
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DNAJC24 IFT122 DNAJC13 UNC45A MYCBP2 COA7 CTR9	1.01e-03	1487	38	7	33957083
Pubmed	Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.	DDX17 CTR9	1.02e-03	43	38	2	26030138
Interaction	LILRA3 interactions	LILRA3 MYCBP2 LILRB1	9.30e-07	11	37	3	int:LILRA3
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	TSHZ1 ZNF30 ZNF268 ZNF730 ZNF441 ZNF345	8.34e-04	718	29	6	28
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	DNAJC24 DNAJC13	2.79e-03	49	29	2	584
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	MASP1 APOH	3.75e-03	57	29	2	1179
GeneFamily	SH2 domain containing	SOCS6 VAV1	1.14e-02	101	29	2	741
Disease	matrix extracellular phosphoglycoprotein measurement	APOH F12	1.53e-05	5	37	2	EFO_0020557
Disease	autosomal dominant nonsyndromic deafness (is_implicated_in)	GREB1L EPHA10	8.35e-05	11	37	2	DOID:0050564 (is_implicated_in)
Disease	peptidyl-glycine alpha-amidating monooxygenase measurement	MYCBP2 F12	8.35e-05	11	37	2	EFO_0801871
Disease	descending aortic diameter	SPTBN4 MASP1 UNC45A	1.85e-04	88	37	3	EFO_0021788
Disease	partial thromboplastin time	APOH F12	4.15e-04	24	37	2	EFO_0004310
Disease	Gastric Adenocarcinoma	MLH1 EPHA10	1.46e-03	45	37	2	C0278701

Protein segments in the cluster

Peptide	Gene	Start	Entry
YKDKATFGCHDGYSL	APOH	226	P02749
FYLSCRCGGKYSVSK	DNAJC24	111	Q6P3W2
VYCVAYAKDGKRFAS	IFT122	56	Q9HBG6
EKLAKEVGTSYGCYF	GK3P	346	Q14409
GYDDSSKGFDYKTCN	MAT2A	91	P31153
TYDGDGYKKRAACLC	NUDT3	11	O95989
KGDCALYASSFKGYI	KLRK1	186	P26718
DLCRYKDSFAAAGYG	EPHA10	946	Q5JZY3
GCEEKLYFGLSEYSK	GREB1L	856	Q9C091
CKDKYYGRKLSVEGF	IP6K3	266	Q96PC2
DGYLAKDGSKFYCSR	FKBP7	61	Q9Y680
ERLAKEVGTSYGCYF	GK2	346	Q14410
CISFNKKDYRGALAY	CTR9	171	Q6PD62
KGDCDKTYGSEFVYS	DNAJC13	1666	O75165
DCGKKDRYGVYSYIH	MASP1	671	P48740
ELCISYSAKKGRGYA	COL25A1-DT	26	Q6ZST2
CEASKGYYLTKALTG	FSIP1	476	Q8NA03
DCKYSYTSGFGAFRI	KRTAP20-3	16	Q3LI60
DYGKCSRLKSTCIYG	DDX17	266	Q92841
VYGCSYKSDVADFDG	CNTNAP5	171	Q8WYK1
CGSDAGYDRFVLYKE	LILRA3	246	Q8N6C8
VDTKASCYDGRGLSY	F12	211	P00748
SSKYSCKGGYLSDGD	SYDE2	611	Q5VT97
SCIYGLKEDGSGSAY	RRAGC	296	Q9HB90
CGSDAGYNRFVLYKD	LILRB1	246	Q8NHL6
DKASFYGFKCFAIGY	MYCBP2	2131	O75592
DGKCAYRASYSDGKL	MLH1	121	P40692
LGKARDYYTRACDGG	COA7	131	Q96BR5
YKYEKCGKAFISGSA	ZNF30	176	P17039
YKCKLCGKGFRSSSY	ZNF441	531	Q8N8Z8
YGCSECGKAFRSKSY	ZNF268	696	Q14587
TKYFGTAKARYDFCA	VAV1	781	P15498
YCVLSKGELGFYKDS	SPTBN4	2446	Q9H254
TGEKSYKCEEYGKAF	ZNF730	196	Q6ZMV8
YECKECGKAFYSGSS	ZNF345	426	Q14585
LYFCGLSDAVLKDGY	TLR5	126	O60602
FGKDDSLFGSCYGKD	SOCS6	36	O14544
YGSVFTGASKFRCKD	TSHZ1	236	Q6ZSZ6
LFKCGDYGGALAAYT	UNC45A	31	Q9H3U1
CGLGKSDRFKSIYAA	JKAMP	181	Q9P055